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Volumn 139, Issue 2, 2016, Pages 243-255

Single-cell profiling approaches to probing tumor heterogeneity

Author keywords

cancer; heterogeneity; microfluidics; molecular analysis; single cell analysis; tumors

Indexed keywords

DNA; RNA;

EID: 84959132634     PISSN: 00207136     EISSN: 10970215     Source Type: Journal    
DOI: 10.1002/ijc.30006     Document Type: Review
Times cited : (50)

References (119)
  • 1
    • 0035720007 scopus 로고    scopus 로고
    • Phenotypic and genetic alterations in mammary stroma: Implications for tumour progression
    • Schor SL, Schor AM., Phenotypic and genetic alterations in mammary stroma: implications for tumour progression. Breast Cancer Res 2001; 3: 373-9.
    • (2001) Breast Cancer Res , vol.3 , pp. 373-379
    • Schor, S.L.1    Schor, A.M.2
  • 2
    • 84856013431 scopus 로고    scopus 로고
    • Clonal evolution in cancer
    • Greaves M, Maley CC., Clonal evolution in cancer. Nature 2012; 481: 306-13.
    • (2012) Nature , vol.481 , pp. 306-313
    • Greaves, M.1    Maley, C.C.2
  • 3
    • 84880507665 scopus 로고    scopus 로고
    • Mutational heterogeneity in cancer and the search for new cancer-Associated genes
    • Lawrence MS, Stojanov P, Polak P, et al., Mutational heterogeneity in cancer and the search for new cancer-Associated genes. Nature 2013; 499: 214-8.
    • (2013) Nature , vol.499 , pp. 214-218
    • Lawrence, M.S.1    Stojanov, P.2    Polak, P.3
  • 4
    • 84884377472 scopus 로고    scopus 로고
    • Tumour heterogeneity and cancer cell plasticity
    • Meacham CE, Morrison SJ., Tumour heterogeneity and cancer cell plasticity. Nature 2013; 501: 328-37.
    • (2013) Nature , vol.501 , pp. 328-337
    • Meacham, C.E.1    Morrison, S.J.2
  • 5
    • 84882455458 scopus 로고    scopus 로고
    • Single-cell sequencing-based technologies will revolutionize whole-organism science
    • Shapiro E, Biezuner T, Linnarsson S., Single-cell sequencing-based technologies will revolutionize whole-organism science. Nat Rev Genet 2013; 14: 618-30.
    • (2013) Nat Rev Genet , vol.14 , pp. 618-630
    • Shapiro, E.1    Biezuner, T.2    Linnarsson, S.3
  • 6
    • 66249136447 scopus 로고    scopus 로고
    • Non-genetic origins of cell-to-cell variability in TRAIL-induced apoptosis
    • Spencer SL, Gaudet S, Albeck JG, et al., Non-genetic origins of cell-to-cell variability in TRAIL-induced apoptosis. Nature 2009; 459: 428-32.
    • (2009) Nature , vol.459 , pp. 428-432
    • Spencer, S.L.1    Gaudet, S.2    Albeck, J.G.3
  • 7
    • 84894585551 scopus 로고    scopus 로고
    • The cancer kaleidoscope
    • McCarthy N., The cancer kaleidoscope. Nat Rev Cancer 2014; 14: 151-2.
    • (2014) Nat Rev Cancer , vol.14 , pp. 151-152
    • McCarthy, N.1
  • 8
    • 79959795786 scopus 로고    scopus 로고
    • Improved survival with vemurafenib in melanoma with BRAF V600E mutation
    • Chapman PB, Hauschild A, Robert C, et al., Improved survival with vemurafenib in melanoma with BRAF V600E mutation. N Engl J Med 2011; 364: 2507-16.
    • (2011) N Engl J Med , vol.364 , pp. 2507-2516
    • Chapman, P.B.1    Hauschild, A.2    Robert, C.3
  • 9
    • 78049425319 scopus 로고    scopus 로고
    • Anaplastic lymphoma kinase inhibition in non-small-cell lung cancer
    • Kwak EL, Bang YJ, Camidge DR, et al., Anaplastic lymphoma kinase inhibition in non-small-cell lung cancer. N Engl J Med 2010; 363: 1693-703.
    • (2010) N Engl J Med , vol.363 , pp. 1693-1703
    • Kwak, E.L.1    Bang, Y.J.2    Camidge, D.R.3
  • 10
    • 84923225259 scopus 로고    scopus 로고
    • Olivier Dormond4 andDipak Datta1,2, Tumor heterogeneity and cancer stem cell paradigm: Updates in concept, controversies and clinical relevance
    • Singh AK, Arya RK, Maheshwari S, et al., Olivier Dormond4 andDipak Datta1,2. Tumor heterogeneity and cancer stem cell paradigm: updates in concept, controversies and clinical relevance. Int J Cancer 2014; 136 (9): 1991-2000.
    • (2014) Int J Cancer , vol.136 , Issue.9 , pp. 1991-2000
    • Singh, A.K.1    Arya, R.K.2    Maheshwari, S.3
  • 11
    • 79953766940 scopus 로고    scopus 로고
    • Tumour evolution inferred by single-cell sequencing
    • Navin N, Kendall J, Troge J, et al., Tumour evolution inferred by single-cell sequencing. Nature 2011; 472: 90-6.
    • (2011) Nature , vol.472 , pp. 90-96
    • Navin, N.1    Kendall, J.2    Troge, J.3
  • 12
    • 84942919186 scopus 로고    scopus 로고
    • Identification of Distinct Tumor Subpopulations in Lung Adenocarcinoma via Single-Cell RNA-seq
    • Min JW, Kim WJ, Han JA, et al., Identification of Distinct Tumor Subpopulations in Lung Adenocarcinoma via Single-Cell RNA-seq. PLoS One 2015; 10: e0135817.
    • (2015) PLoS One , vol.10 , pp. e0135817
    • Min, J.W.1    Kim, W.J.2    Han, J.A.3
  • 13
    • 84863922124 scopus 로고    scopus 로고
    • Comprehensive molecular characterization of human colon and rectal cancer
    • Network CGA., Comprehensive molecular characterization of human colon and rectal cancer. Nature 2012; 487: 330-7.
    • (2012) Nature , vol.487 , pp. 330-337
    • Network, C.G.A.1
  • 14
    • 14644407525 scopus 로고    scopus 로고
    • The role of apoptosis in cancer development and treatment response
    • Brown JM, Attardi LD., The role of apoptosis in cancer development and treatment response. Nat Rev Cancer 2005; 5: 231-7.
    • (2005) Nat Rev Cancer , vol.5 , pp. 231-237
    • Brown, J.M.1    Attardi, L.D.2
  • 15
    • 84874598318 scopus 로고    scopus 로고
    • Intratumor heterogeneity in human glioblastoma reflects cancer evolutionary dynamics
    • Sottoriva A, Spiteri I, Piccirillo SG, et al., Intratumor heterogeneity in human glioblastoma reflects cancer evolutionary dynamics. Proc Natl Acad Sci USA 2013; 110: 4009-14.
    • (2013) Proc Natl Acad Sci USA , vol.110 , pp. 4009-4014
    • Sottoriva, A.1    Spiteri, I.2    Piccirillo, S.G.3
  • 16
    • 84902549992 scopus 로고    scopus 로고
    • Intertumor heterogeneity of non-small-cell lung carcinomas revealed by multiplexed mutation profiling and integrative genomics
    • Tan DS, Camilleri-Broet S, Tan EH, et al., Intertumor heterogeneity of non-small-cell lung carcinomas revealed by multiplexed mutation profiling and integrative genomics. Int J Cancer 2014; 135: 1092-100.
    • (2014) Int J Cancer , vol.135 , pp. 1092-1100
    • Tan, D.S.1    Camilleri-Broet, S.2    Tan, E.H.3
  • 17
    • 84863393080 scopus 로고    scopus 로고
    • Intratumor heterogeneity and branched evolution revealed by multiregion sequencing
    • Gerlinger M, Rowan AJ, Horswell S, et al., Intratumor heterogeneity and branched evolution revealed by multiregion sequencing. N Engl J Med 2012; 366: 883-92.
    • (2012) N Engl J Med , vol.366 , pp. 883-892
    • Gerlinger, M.1    Rowan, A.J.2    Horswell, S.3
  • 18
    • 80053406583 scopus 로고    scopus 로고
    • Heterogeneity in breast cancer
    • Polyak K., Heterogeneity in breast cancer. J Clin Invest 2011; 121: 3786-8.
    • (2011) J Clin Invest , vol.121 , pp. 3786-3788
    • Polyak, K.1
  • 19
    • 84924627714 scopus 로고    scopus 로고
    • Intratumor DNA methylation heterogeneity reflects clonal evolution in aggressive prostate cancer
    • Brocks D, Assenov Y, Minner S, et al., Intratumor DNA methylation heterogeneity reflects clonal evolution in aggressive prostate cancer. Cell Rep 2014; 8: 798-806.
    • (2014) Cell Rep , vol.8 , pp. 798-806
    • Brocks, D.1    Assenov, Y.2    Minner, S.3
  • 20
    • 84924048777 scopus 로고    scopus 로고
    • Tumor evolution and intratumor heterogeneity of an epithelial ovarian cancer investigated using next-generation sequencing
    • Lee JY, Yoon JK, Kim B, et al., Tumor evolution and intratumor heterogeneity of an epithelial ovarian cancer investigated using next-generation sequencing. BMC Cancer 2015; 15: 85
    • (2015) BMC Cancer , vol.15 , pp. 85
    • Lee, J.Y.1    Yoon, J.K.2    Kim, B.3
  • 21
    • 84908460595 scopus 로고    scopus 로고
    • Multiplatform analysis of 12 cancer types reveals molecular classification within and across tissues of origin
    • Hoadley KA, Yau C, Wolf DM, et al., Multiplatform analysis of 12 cancer types reveals molecular classification within and across tissues of origin. Cell 2014; 158: 929-44.
    • (2014) Cell , vol.158 , pp. 929-944
    • Hoadley, K.A.1    Yau, C.2    Wolf, D.M.3
  • 22
    • 79551649114 scopus 로고    scopus 로고
    • Basal-like and triple-negative breast cancers: A critical review with an emphasis on the implications for pathologists and oncologists
    • Badve S, Dabbs DJ, Schnitt SJ, et al., Basal-like and triple-negative breast cancers: a critical review with an emphasis on the implications for pathologists and oncologists. Mod Pathol 2011; 24: 157-67.
    • (2011) Mod Pathol , vol.24 , pp. 157-167
    • Badve, S.1    Dabbs, D.J.2    Schnitt, S.J.3
  • 23
    • 66249109653 scopus 로고    scopus 로고
    • Characterization of a naturally occurring breast cancer subset enriched in epithelial-to-mesenchymal transition and stem cell characteristics
    • Hennessy BT, Gonzalez-Angulo AM, Stemke-Hale K, et al., Characterization of a naturally occurring breast cancer subset enriched in epithelial-to-mesenchymal transition and stem cell characteristics. Cancer Res 2009; 69: 4116-24.
    • (2009) Cancer Res , vol.69 , pp. 4116-4124
    • Hennessy, B.T.1    Gonzalez-Angulo, A.M.2    Stemke-Hale, K.3
  • 24
    • 75649149550 scopus 로고    scopus 로고
    • Histological and molecular types of breast cancer: Is there a unifying taxonomy?
    • Weigelt B, Reis-Filho JS., Histological and molecular types of breast cancer: is there a unifying taxonomy? Nat Rev Clin Oncol 2009; 6: 718-30.
    • (2009) Nat Rev Clin Oncol , vol.6 , pp. 718-730
    • Weigelt, B.1    Reis-Filho, J.S.2
  • 25
    • 57749115814 scopus 로고    scopus 로고
    • The role of molecular analysis in breast cancer
    • Geyer FC, Marchio C, Reis-Filho JS., The role of molecular analysis in breast cancer. Pathology 2009; 41: 77-88.
    • (2009) Pathology , vol.41 , pp. 77-88
    • Geyer, F.C.1    Marchio, C.2    Reis-Filho, J.S.3
  • 26
    • 84655161546 scopus 로고    scopus 로고
    • Challenges translating breast cancer gene signatures into the clinic
    • Weigelt B, Pusztai L, Ashworth A, et al., Challenges translating breast cancer gene signatures into the clinic. Nat Rev Clin Oncol 2012; 9: 58-64.
    • (2012) Nat Rev Clin Oncol , vol.9 , pp. 58-64
    • Weigelt, B.1    Pusztai, L.2    Ashworth, A.3
  • 27
    • 84878594500 scopus 로고    scopus 로고
    • Triple-negative breast cancer: BRCAness and concordance of clinical features with BRCA1-mutation carriers
    • Lips EH, Mulder L, Oonk A, et al., Triple-negative breast cancer: BRCAness and concordance of clinical features with BRCA1-mutation carriers. Br J Cancer 2013; 108: 2172-7.
    • (2013) Br J Cancer , vol.108 , pp. 2172-2177
    • Lips, E.H.1    Mulder, L.2    Oonk, A.3
  • 28
    • 84937573360 scopus 로고    scopus 로고
    • Single-cell mRNA sequencing identifies subclonal heterogeneity in anti-cancer drug responses of lung adenocarcinoma cells
    • Kim KT, Lee HW, Lee HO, et al., Single-cell mRNA sequencing identifies subclonal heterogeneity in anti-cancer drug responses of lung adenocarcinoma cells. Genome Biol 2015; 16: 127
    • (2015) Genome Biol , vol.16 , pp. 127
    • Kim, K.T.1    Lee, H.W.2    Lee, H.O.3
  • 29
    • 0019941487 scopus 로고
    • Biological diversity in metastatic neoplasms: Origins and implications
    • Fidler IJ, Hart IR., Biological diversity in metastatic neoplasms: origins and implications. Science 1982; 217: 998-1003.
    • (1982) Science , vol.217 , pp. 998-1003
    • Fidler, I.J.1    Hart, I.R.2
  • 30
    • 77951139631 scopus 로고    scopus 로고
    • Genome remodelling in a basal-like breast cancer metastasis and xenograft
    • Ding L, Ellis MJ, Li S, et al., Genome remodelling in a basal-like breast cancer metastasis and xenograft. Nature 2010; 464: 999-1005.
    • (2010) Nature , vol.464 , pp. 999-1005
    • Ding, L.1    Ellis, M.J.2    Li, S.3
  • 31
    • 57149118627 scopus 로고    scopus 로고
    • Genomic analysis of the clonal origins of relapsed acute lymphoblastic leukemia
    • Mullighan CG, Phillips LA, Su X, et al., Genomic analysis of the clonal origins of relapsed acute lymphoblastic leukemia. Science 2008; 322: 1377-80.
    • (2008) Science , vol.322 , pp. 1377-1380
    • Mullighan, C.G.1    Phillips, L.A.2    Su, X.3
  • 32
    • 84887456252 scopus 로고    scopus 로고
    • The epigenetics of epithelial-mesenchymal plasticity in cancer
    • Tam WL, Weinberg RA., The epigenetics of epithelial-mesenchymal plasticity in cancer. Nat Med 2013; 19: 1438-49.
    • (2013) Nat Med , vol.19 , pp. 1438-1449
    • Tam, W.L.1    Weinberg, R.A.2
  • 33
    • 84860214990 scopus 로고    scopus 로고
    • Intra-tumour heterogeneity: A looking glass for cancer?
    • Marusyk A, Almendro V, Polyak K., Intra-tumour heterogeneity: a looking glass for cancer? Nat Rev Cancer 2012; 12: 323-34.
    • (2012) Nat Rev Cancer , vol.12 , pp. 323-334
    • Marusyk, A.1    Almendro, V.2    Polyak, K.3
  • 34
    • 84865827060 scopus 로고    scopus 로고
    • Clonal evolution of preleukemic hematopoietic stem cells precedes human acute myeloid leukemia
    • Jan M, Snyder TM, Corces-Zimmerman MR, et al., Clonal evolution of preleukemic hematopoietic stem cells precedes human acute myeloid leukemia. Sci Transl Med 2012; 4: 149ra18
    • (2012) Sci Transl Med , vol.4 , pp. 149ra18
    • Jan, M.1    Snyder, T.M.2    Corces-Zimmerman, M.R.3
  • 35
  • 36
    • 84876489727 scopus 로고    scopus 로고
    • Cancer stem cells: The challenges ahead
    • Medema JP., Cancer stem cells: the challenges ahead. Nat Cell Biol 2013; 15: 338-44.
    • (2013) Nat Cell Biol , vol.15 , pp. 338-344
    • Medema, J.P.1
  • 37
    • 84906731563 scopus 로고    scopus 로고
    • Challenges in circulating tumour cell research
    • Alix-Panabieres C, Pantel K., Challenges in circulating tumour cell research. Nat Rev Cancer 2014; 14: 623-31.
    • (2014) Nat Rev Cancer , vol.14 , pp. 623-631
    • Alix-Panabieres, C.1    Pantel, K.2
  • 38
    • 84897873301 scopus 로고    scopus 로고
    • The in vivo activation of persistent nanophosphors for optical imaging of vascularization, tumours and grafted cells
    • Maldiney T, Bessière A, Seguin J, et al., The in vivo activation of persistent nanophosphors for optical imaging of vascularization, tumours and grafted cells. Nat Mater 2014; 13: 418-26.
    • (2014) Nat Mater , vol.13 , pp. 418-426
    • Maldiney, T.1    Bessière, A.2    Seguin, J.3
  • 39
    • 84933278862 scopus 로고    scopus 로고
    • Clinical management of breast cancer heterogeneity
    • Zardavas D, Irrthum A, Swanton C, et al., Clinical management of breast cancer heterogeneity. Nat Rev Clin Oncol 2015; 12: 381-394.
    • (2015) Nat Rev Clin Oncol , vol.12 , pp. 381-394
    • Zardavas, D.1    Irrthum, A.2    Swanton, C.3
  • 40
    • 1142274391 scopus 로고    scopus 로고
    • Streaming dielectrophoresis for continuous-flow microfluidic devices
    • Cummings EB., Streaming dielectrophoresis for continuous-flow microfluidic devices. IEEE Eng Med Biol Mag 2003; 22: 75-84.
    • (2003) IEEE Eng Med Biol Mag , vol.22 , pp. 75-84
    • Cummings, E.B.1
  • 41
    • 46249105330 scopus 로고    scopus 로고
    • Single-cell phospho-protein analysis by flow cytometry
    • Chapter 8:Unit 8.
    • Schulz KR, Danna EA, Krutzik PO, et al., Single-cell phospho-protein analysis by flow cytometry. Curr Protoc Immunol 2012;Chapter 8:Unit 8. 17: 1-20.
    • (2012) Curr Protoc Immunol , vol.17 , pp. 1-20
    • Schulz, K.R.1    Danna, E.A.2    Krutzik, P.O.3
  • 42
    • 68849103521 scopus 로고    scopus 로고
    • Mass cytometry: Technique for real time single cell multitarget immunoassay based on inductively coupled plasma time-of-flight mass spectrometry
    • Bandura DR, Baranov VI, Ornatsky OI, et al., Mass cytometry: technique for real time single cell multitarget immunoassay based on inductively coupled plasma time-of-flight mass spectrometry. Anal Chem 2009; 81: 6813-22.
    • (2009) Anal Chem , vol.81 , pp. 6813-6822
    • Bandura, D.R.1    Baranov, V.I.2    Ornatsky, O.I.3
  • 43
    • 84897954497 scopus 로고    scopus 로고
    • Highly multiplexed imaging of tumor tissues with subcellular resolution by mass cytometry
    • Giesen C, Wang HAO, Schapiro D, et al., Highly multiplexed imaging of tumor tissues with subcellular resolution by mass cytometry. Nat Meth 2014; 11: 417-22.
    • (2014) Nat Meth , vol.11 , pp. 417-422
    • Giesen, C.1    Wang, H.A.O.2    Schapiro, D.3
  • 44
    • 82755189529 scopus 로고    scopus 로고
    • Live-cell imaging of tumor proteolysis: Impact of cellular and non-cellular microenvironment
    • Rothberg JM, Sameni M, Moin K, et al., Live-cell imaging of tumor proteolysis: impact of cellular and non-cellular microenvironment. Biochim Biophys Acta 2012; 1824: 123-32.
    • (2012) Biochim Biophys Acta , vol.1824 , pp. 123-132
    • Rothberg, J.M.1    Sameni, M.2    Moin, K.3
  • 45
    • 84874598091 scopus 로고    scopus 로고
    • Single-cell and subcellular pharmacokinetic imaging allows insight into drug action in vivo
    • Thurber GM, Yang KS, Reiner T, et al., Single-cell and subcellular pharmacokinetic imaging allows insight into drug action in vivo. Nat Commun 2013; 4: 1504.
    • (2013) Nat Commun , vol.4 , pp. 1504
    • Thurber, G.M.1    Yang, K.S.2    Reiner, T.3
  • 46
    • 84861216623 scopus 로고    scopus 로고
    • Hydrodynamic stretching of single cells for large population mechanical phenotyping
    • Gossett DR, Tse HTK, Lee SA, et al., Hydrodynamic stretching of single cells for large population mechanical phenotyping. Proc Natl Acad Sci USA 2012; 109: 7630-5.
    • (2012) Proc Natl Acad Sci USA , vol.109 , pp. 7630-7635
    • Gossett, D.R.1    Tse, H.T.K.2    Lee, S.A.3
  • 47
    • 84910614274 scopus 로고    scopus 로고
    • Jetting microfluidics with size-sorting capability for single-cell protease detection
    • Jing T, Ramji R, Warkiani ME, et al., Jetting microfluidics with size-sorting capability for single-cell protease detection. Biosens Bioelectron 2014;66:19-23.
    • (2014) Biosens Bioelectron , vol.66 , pp. 19-23
    • Jing, T.1    Ramji, R.2    Warkiani, M.E.3
  • 48
    • 84880554705 scopus 로고    scopus 로고
    • Cell-based drug combination screening with a microfluidic droplet array system
    • Du GS, Pan JZ, Zhao SP, et al., Cell-based drug combination screening with a microfluidic droplet array system. Anal Chem 2013; 85: 6740-7.
    • (2013) Anal Chem , vol.85 , pp. 6740-6747
    • Du, G.S.1    Pan, J.Z.2    Zhao, S.P.3
  • 49
    • 84890755349 scopus 로고    scopus 로고
    • Advances in high-throughput single-cell microtechnologies
    • Weaver WM, Tseng P, Kunze A, et al., Advances in high-throughput single-cell microtechnologies. Curr Opin Biotechnol 2014; 25: 114-23.
    • (2014) Curr Opin Biotechnol , vol.25 , pp. 114-123
    • Weaver, W.M.1    Tseng, P.2    Kunze, A.3
  • 50
    • 84896739948 scopus 로고    scopus 로고
    • Single cell genomics: Advances and future perspectives
    • Macaulay IC, Voet T., Single cell genomics: advances and future perspectives. PLoS Genet 2014; 10: e1004126.
    • (2014) PLoS Genet , vol.10 , pp. e1004126
    • MacAulay, I.C.1    Voet, T.2
  • 51
    • 83255177150 scopus 로고    scopus 로고
    • Single-cell dissection of transcriptional heterogeneity in human colon tumors
    • Dalerba P, Kalisky T, Sahoo D, et al., Single-cell dissection of transcriptional heterogeneity in human colon tumors. Nat Biotechnol 2011; 29: 1120-7.
    • (2011) Nat Biotechnol , vol.29 , pp. 1120-1127
    • Dalerba, P.1    Kalisky, T.2    Sahoo, D.3
  • 52
    • 84931562619 scopus 로고    scopus 로고
    • Single-cell gene expression signatures reveal melanoma cell heterogeneity
    • Ennen M, Keime C, Kobi D, et al., Single-cell gene expression signatures reveal melanoma cell heterogeneity. Oncogene 2014;34(25):3251-63.
    • (2014) Oncogene , vol.34 , Issue.25 , pp. 3251
    • Ennen, M.1    Keime, C.2    Kobi, D.3
  • 53
    • 84864880991 scopus 로고    scopus 로고
    • Full-length mRNA-Seq from single-cell levels of RNA and individual circulating tumor cells
    • Ramskold D, Luo S, Wang YC, et al., Full-length mRNA-Seq from single-cell levels of RNA and individual circulating tumor cells. Nat Biotechnol 2012; 30: 777-82.
    • (2012) Nat Biotechnol , vol.30 , pp. 777-782
    • Ramskold, D.1    Luo, S.2    Wang, Y.C.3
  • 54
    • 77953121190 scopus 로고    scopus 로고
    • Single cell analysis: The new frontier in 'omics'
    • Wang D, Bodovitz S., Single cell analysis: the new frontier in 'omics'. Trends Biotechnol 2010; 28: 281-90.
    • (2010) Trends Biotechnol , vol.28 , pp. 281-290
    • Wang, D.1    Bodovitz, S.2
  • 55
    • 77955359943 scopus 로고    scopus 로고
    • A microfluidic platform for systems pathology: Multiparameter single-cell signaling measurements of clinical brain tumor specimens
    • Sun J, Masterman-Smith MD, Graham NA, et al., A microfluidic platform for systems pathology: multiparameter single-cell signaling measurements of clinical brain tumor specimens. Cancer Res 2010; 70: 6128-38.
    • (2010) Cancer Res , vol.70 , pp. 6128-6138
    • Sun, J.1    Masterman-Smith, M.D.2    Graham, N.A.3
  • 56
    • 84896741640 scopus 로고    scopus 로고
    • Microfluidic probe for single-cell analysis in adherent tissue culture
    • Sarkar A, Kolitz S, Lauffenburger DA, et al., Microfluidic probe for single-cell analysis in adherent tissue culture. Nat Commun 2014; 5: 3421
    • (2014) Nat Commun , vol.5 , pp. 3421
    • Sarkar, A.1    Kolitz, S.2    Lauffenburger, D.A.3
  • 57
    • 84869455584 scopus 로고    scopus 로고
    • Photocleavable DNA barcode-Antibody conjugates allow sensitive and multiplexed protein analysis in single cells
    • Agasti SS, Liong M, Peterson VM, et al., Photocleavable DNA barcode-Antibody conjugates allow sensitive and multiplexed protein analysis in single cells. J Am Chem Soc 2012; 134: 18499-502.
    • (2012) J Am Chem Soc , vol.134 , pp. 18499-18502
    • Agasti, S.S.1    Liong, M.2    Peterson, V.M.3
  • 58
    • 84893421205 scopus 로고    scopus 로고
    • Dejan Juric2 CMC, 2 and Ralph Weissleder1,2,3,4,†. Cancer Cell Profiling by Barcoding Allows Multiplexed Protein Analysis in Fine-Needle Aspirates
    • Ullal AV, Peterson V, Agasti SS, et al., Dejan Juric2 CMC, 2 and Ralph Weissleder1,2,3,4,†. Cancer Cell Profiling by Barcoding Allows Multiplexed Protein Analysis in Fine-Needle Aspirates. Sci Transl Med 2014; 6: 219ra9.
    • (2014) Sci Transl Med , vol.6 , pp. 219ra9
    • Ullal, A.V.1    Peterson, V.2    Agasti, S.S.3
  • 59
    • 84880280631 scopus 로고    scopus 로고
    • ViSNE enables visualization of high dimensional single-cell data and reveals phenotypic heterogeneity of leukemia
    • Amir E-AD, Davis KL, Tadmor MD, et al., viSNE enables visualization of high dimensional single-cell data and reveals phenotypic heterogeneity of leukemia. Nat Biotech 2013; 31: 545-52.
    • (2013) Nat Biotech , vol.31 , pp. 545-552
    • Amir, E.-A.1    Davis, K.L.2    Tadmor, M.D.3
  • 60
    • 84912019634 scopus 로고    scopus 로고
    • Single cell lipidomics of SKBR-3 breast cancer cells by using time-of-flight secondary-ion mass spectrometry
    • Ide Y, Waki M, Ishizaki I, et al., Single cell lipidomics of SKBR-3 breast cancer cells by using time-of-flight secondary-ion mass spectrometry. Surf Interface Anal 2014; 46 (S1): 181-184.
    • (2014) Surf Interface Anal , vol.46 , Issue.S1 , pp. 181-184
    • Ide, Y.1    Waki, M.2    Ishizaki, I.3
  • 61
    • 84919465088 scopus 로고    scopus 로고
    • ToF-SIMS as tool for profiling lipids in cancer and other diseases
    • Denbigh JL, Lockyer NP., ToF-SIMS as tool for profiling lipids in cancer and other diseases. Mater Sci Technol 2014;31(2):137-147.
    • (2014) Mater Sci Technol , vol.31 , Issue.2 , pp. 137
    • Denbigh, J.L.1    Lockyer, N.P.2
  • 62
    • 35548992879 scopus 로고    scopus 로고
    • Clathrate nanostructures for mass spectrometry
    • Northen TR, Yanes O, Northen MT, et al., Clathrate nanostructures for mass spectrometry. Nature 2007; 449: 1033-6.
    • (2007) Nature , vol.449 , pp. 1033-1036
    • Northen, T.R.1    Yanes, O.2    Northen, M.T.3
  • 63
    • 84878458746 scopus 로고    scopus 로고
    • Monitoring metabolic responses to chemotherapy in single cells and tumors using nanostructure-initiator mass spectrometry (NIMS) imaging
    • O'Brien PJ, Lee M, Spilker ME, et al., Monitoring metabolic responses to chemotherapy in single cells and tumors using nanostructure-initiator mass spectrometry (NIMS) imaging. Cancer Metab 2013; 1: 4.
    • (2013) Cancer Metab , vol.1 , pp. 4
    • O'Brien, P.J.1    Lee, M.2    Spilker, M.E.3
  • 64
    • 84906238686 scopus 로고    scopus 로고
    • Clonal evolution in breast cancer revealed by single nucleus genome sequencing
    • Wang Y, Waters J, Leung ML, et al., Clonal evolution in breast cancer revealed by single nucleus genome sequencing. Nature 2014; 512: 155-60.
    • (2014) Nature , vol.512 , pp. 155-160
    • Wang, Y.1    Waters, J.2    Leung, M.L.3
  • 65
    • 84877865227 scopus 로고    scopus 로고
    • Complex tumor genomes inferred from single circulating tumor cells by array-CGH and next-generation sequencing
    • Heitzer E, Auer M, Gasch C, et al., Complex tumor genomes inferred from single circulating tumor cells by array-CGH and next-generation sequencing. Cancer Res 2013; 73: 2965-75.
    • (2013) Cancer Res , vol.73 , pp. 2965-2975
    • Heitzer, E.1    Auer, M.2    Gasch, C.3
  • 66
    • 84872048462 scopus 로고    scopus 로고
    • Heterogeneity of epidermal growth factor receptor status and mutations of KRAS/PIK3CA in circulating tumor cells of patients with colorectal cancer
    • Gasch C, Bauernhofer T, Pichler M, et al., Heterogeneity of epidermal growth factor receptor status and mutations of KRAS/PIK3CA in circulating tumor cells of patients with colorectal cancer. Clin Chem 2013; 59: 252-60.
    • (2013) Clin Chem , vol.59 , pp. 252-260
    • Gasch, C.1    Bauernhofer, T.2    Pichler, M.3
  • 67
    • 84901853867 scopus 로고    scopus 로고
    • Cancer epigenetics: Tumor heterogeneity, plasticity of stem-like states, and drug resistance
    • Easwaran H, Tsai H-C, Baylin SB., Cancer epigenetics: tumor heterogeneity, plasticity of stem-like states, and drug resistance. Mol Cell 2014; 54: 716-27.
    • (2014) Mol Cell , vol.54 , pp. 716-727
    • Easwaran, H.1    Tsai, H.-C.2    Baylin, S.B.3
  • 68
    • 84883474570 scopus 로고    scopus 로고
    • Single-cell DNA-methylation analysis reveals epigenetic chimerism in preimplantation embryos
    • Lorthongpanich C, Cheow LF, Balu S, et al., Single-cell DNA-methylation analysis reveals epigenetic chimerism in preimplantation embryos. Science 2013; 341: 1110-2.
    • (2013) Science , vol.341 , pp. 1110-1112
    • Lorthongpanich, C.1    Cheow, L.F.2    Balu, S.3
  • 69
    • 84876948946 scopus 로고    scopus 로고
    • Single-cell analysis of circulating tumor cells identifies cumulative expression patterns of EMT-related genes in metastatic prostate cancer
    • Chen CL, Mahalingam D, Osmulski P, et al., Single-cell analysis of circulating tumor cells identifies cumulative expression patterns of EMT-related genes in metastatic prostate cancer. Prostate 2013; 73: 813-26.
    • (2013) Prostate , vol.73 , pp. 813-826
    • Chen, C.L.1    Mahalingam, D.2    Osmulski, P.3
  • 70
    • 84942904757 scopus 로고    scopus 로고
    • RNA-Seq of single prostate CTCs implicates noncanonical Wnt signaling in antiandrogen resistance
    • Miyamoto DT, Zheng Y, Wittner BS, et al., RNA-Seq of single prostate CTCs implicates noncanonical Wnt signaling in antiandrogen resistance. Science 2015; 349: 1351-6.
    • (2015) Science , vol.349 , pp. 1351-1356
    • Miyamoto, D.T.1    Zheng, Y.2    Wittner, B.S.3
  • 71
    • 84902668801 scopus 로고    scopus 로고
    • Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma
    • Patel AP, Tirosh I, Trombetta JJ, et al., Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma. Science 2014; 344: 1396-401.
    • (2014) Science , vol.344 , pp. 1396-1401
    • Patel, A.P.1    Tirosh, I.2    Trombetta, J.J.3
  • 72
    • 84914706587 scopus 로고    scopus 로고
    • Single-cell analyses of transcriptional heterogeneity during drug tolerance transition in cancer cells by RNA sequencing
    • Lee MC, Lopez-Diaz FJ, Khan SY, et al., Single-cell analyses of transcriptional heterogeneity during drug tolerance transition in cancer cells by RNA sequencing. Proc Natl Acad Sci USA 2014; 111: E4726-35.
    • (2014) Proc Natl Acad Sci USA , vol.111 , pp. E4726-E4735
    • Lee, M.C.1    Lopez-Diaz, F.J.2    Khan, S.Y.3
  • 73
    • 76049098292 scopus 로고    scopus 로고
    • Prevalence and heterogeneity of KRAS, BRAF, and PIK3CA mutations in primary colorectal adenocarcinomas and their corresponding metastases
    • Baldus SE, Schaefer K-L, Engers R, et al., Prevalence and heterogeneity of KRAS, BRAF, and PIK3CA mutations in primary colorectal adenocarcinomas and their corresponding metastases. Clin Cancer Res 2010; 16: 790
    • (2010) Clin Cancer Res , vol.16 , pp. 790
    • Baldus, S.E.1    Schaefer, K.-L.2    Engers, R.3
  • 74
    • 84893962650 scopus 로고    scopus 로고
    • Tumor heterogeneity revealed by KRAS, BRAF, and PIK3CA pyrosequencing: KRAS and PIK3CA intratumor mutation profile differences and their therapeutic implications
    • Kosmidou V, Oikonomou E, Vlassi M, et al., Tumor heterogeneity revealed by KRAS, BRAF, and PIK3CA pyrosequencing: KRAS and PIK3CA intratumor mutation profile differences and their therapeutic implications. Hum Mutat 2014; 35: 329-40.
    • (2014) Hum Mutat , vol.35 , pp. 329-340
    • Kosmidou, V.1    Oikonomou, E.2    Vlassi, M.3
  • 75
    • 84863000299 scopus 로고    scopus 로고
    • The molecular evolution of acquired resistance to targeted EGFR blockade in colorectal cancers
    • Diaz LA, Jr., Williams RT, Wu J, et al., The molecular evolution of acquired resistance to targeted EGFR blockade in colorectal cancers. Nature 2012; 486: 537-40.
    • (2012) Nature , vol.486 , pp. 537-540
    • Diaz, L.A.1    Williams, R.T.2    Wu, J.3
  • 76
    • 84886698315 scopus 로고    scopus 로고
    • Innate and adaptive immune cells in the tumor microenvironment
    • Gajewski TF, Schreiber H, Fu Y-X., Innate and adaptive immune cells in the tumor microenvironment. Nat Immunol 2013; 14: 1014-22.
    • (2013) Nat Immunol , vol.14 , pp. 1014-1022
    • Gajewski, T.F.1    Schreiber, H.2    Fu, Y.-X.3
  • 77
    • 84899929564 scopus 로고    scopus 로고
    • Heterogeneity in immune responses: From populations to single cells
    • Satija R, Shalek AK., Heterogeneity in immune responses: from populations to single cells. Trends Immunol 2014; 35: 219-29.
    • (2014) Trends Immunol , vol.35 , pp. 219-229
    • Satija, R.1    Shalek, A.K.2
  • 78
    • 79955750055 scopus 로고    scopus 로고
    • Nolan Single-cell mass cytometry of differential immune and drug responses across a human hematopoietic continuum
    • Bendall SC, Simonds EF, Qiu P, et al., Nolan Single-cell mass cytometry of differential immune and drug responses across a human hematopoietic continuum. Science 2011; 332: 687-96.
    • (2011) Science , vol.332 , pp. 687-696
    • Bendall, S.C.1    Simonds, E.F.2    Qiu, P.3
  • 79
    • 84856004321 scopus 로고    scopus 로고
    • Single-cell proteomic chip for profiling intracellular signaling pathways in single tumor cells
    • Shi Q, Qin L, Wei W, et al., Single-cell proteomic chip for profiling intracellular signaling pathways in single tumor cells. Proc Natl Acad Sci USA 2011;109(2):419-424.
    • (2011) Proc Natl Acad Sci USA , vol.109 , Issue.2 , pp. 419
    • Shi, Q.1    Qin, L.2    Wei, W.3
  • 80
    • 77950273418 scopus 로고    scopus 로고
    • Simultaneous visualization of protumorigenic Src and MT1-MMP activities with fluorescence resonance energy transfer
    • Ouyang M, Huang H, Shaner NC, et al., Simultaneous visualization of protumorigenic Src and MT1-MMP activities with fluorescence resonance energy transfer. Cancer Res 2010; 70: 2204-12.
    • (2010) Cancer Res , vol.70 , pp. 2204-2212
    • Ouyang, M.1    Huang, H.2    Shaner, N.C.3
  • 82
    • 84923225259 scopus 로고    scopus 로고
    • Tumor heterogeneity and cancer stem cell paradigm: Updates in concept, controversies and clinical relevance
    • Singh AK, Arya RK, Maheshwari S, et al., Tumor heterogeneity and cancer stem cell paradigm: updates in concept, controversies and clinical relevance. Int J Cancer 2015; 136: 1991-2000.
    • (2015) Int J Cancer , vol.136 , pp. 1991-2000
    • Singh, A.K.1    Arya, R.K.2    Maheshwari, S.3
  • 83
    • 84904396672 scopus 로고    scopus 로고
    • Clinical validation of an ultra high-throughput spiral microfluidics for the detection and enrichment of viable circulating tumor cells
    • Khoo BL, Warkiani ME, Tan DS, et al., Clinical validation of an ultra high-throughput spiral microfluidics for the detection and enrichment of viable circulating tumor cells. PLoS One 2014; 9: e99409.
    • (2014) PLoS One , vol.9 , pp. e99409
    • Khoo, B.L.1    Warkiani, M.E.2    Tan, D.S.3
  • 84
    • 84875752240 scopus 로고    scopus 로고
    • Emerging targeted agents in metastatic breast cancer
    • Zardavas D, Baselga J, Piccart M., Emerging targeted agents in metastatic breast cancer. Nat Rev Clin Oncol 2013; 10: 191-210.
    • (2013) Nat Rev Clin Oncol , vol.10 , pp. 191-210
    • Zardavas, D.1    Baselga, J.2    Piccart, M.3
  • 85
    • 84873811988 scopus 로고    scopus 로고
    • Circulating breast tumor cells exhibit dynamic changes in epithelial and mesenchymal composition
    • Yu M, Bardia A, Wittner BS, et al., Circulating breast tumor cells exhibit dynamic changes in epithelial and mesenchymal composition. Science 2013; 339: 580-4.
    • (2013) Science , vol.339 , pp. 580-584
    • Yu, M.1    Bardia, A.2    Wittner, B.S.3
  • 86
    • 84889040481 scopus 로고    scopus 로고
    • Technologies for detection of circulating tumor cells: Facts and vision
    • Alix-Panabieres C, Pantel K., Technologies for detection of circulating tumor cells: facts and vision. Lab Chip 2014; 14: 57-62.
    • (2014) Lab Chip , vol.14 , pp. 57-62
    • Alix-Panabieres, C.1    Pantel, K.2
  • 87
    • 84860750247 scopus 로고    scopus 로고
    • Sensitive and high-throughput isolation of rare cells from peripheral blood with ensemble-decision aliquot ranking
    • Schiro PG, Zhao M, Kuo JS, et al., Sensitive and high-throughput isolation of rare cells from peripheral blood with ensemble-decision aliquot ranking. Angew Chem Int Ed Engl 2012; 51: 4618-22.
    • (2012) Angew Chem Int Ed Engl , vol.51 , pp. 4618-4622
    • Schiro, P.G.1    Zhao, M.2    Kuo, J.S.3
  • 88
    • 84900333051 scopus 로고    scopus 로고
    • Whole-exome sequencing of circulating tumor cells provides a window into metastatic prostate cancer
    • Lohr JG, Adalsteinsson VA, Cibulskis K, et al., Whole-exome sequencing of circulating tumor cells provides a window into metastatic prostate cancer. Nat Biotechnol 2014; 32: 479-84.
    • (2014) Nat Biotechnol , vol.32 , pp. 479-484
    • Lohr, J.G.1    Adalsteinsson, V.A.2    Cibulskis, K.3
  • 89
    • 36749012914 scopus 로고    scopus 로고
    • Persistent use of "false" cell lines
    • Lacroix M., Persistent use of "false" cell lines. Int J Cancer 2007; 122: 1-4.
    • (2007) Int J Cancer , vol.122 , pp. 1-4
    • Lacroix, M.1
  • 90
    • 79952265771 scopus 로고    scopus 로고
    • Cytomorphology of circulating colorectal tumor cells: A small case series
    • Marrinucci D, Bethel K, Lazar D, et al., Cytomorphology of circulating colorectal tumor cells: a small case series. J Oncol 2010; 2010:1-7.
    • (2010) J Oncol , vol.2010 , pp. 1
    • Marrinucci, D.1    Bethel, K.2    Lazar, D.3
  • 91
    • 84860601923 scopus 로고    scopus 로고
    • Single Cell Profiling of Circulating Tumor Cells: Transcriptional Heterogeneity and Diversity from Breast Cancer Cell Lines
    • Powell AA, Talasaz AH, Zhang H, et al., Single Cell Profiling of Circulating Tumor Cells: Transcriptional Heterogeneity and Diversity from Breast Cancer Cell Lines. PLoS One 2012; 7: e33788.
    • (2012) PLoS One , vol.7 , pp. e33788
    • Powell, A.A.1    Talasaz, A.H.2    Zhang, H.3
  • 92
    • 84867641057 scopus 로고    scopus 로고
    • Single-cell metabolomics: Changes in the metabolome of freshly isolated and cultured neurons
    • Nemes P, Knolhoff AM, Rubakhin SS, et al., Single-cell metabolomics: changes in the metabolome of freshly isolated and cultured neurons. ACS Chem Neurosci 2012; 3:782-792.
    • (2012) ACS Chem Neurosci , vol.3 , pp. 782
    • Nemes, P.1    Knolhoff, A.M.2    Rubakhin, S.S.3
  • 93
    • 84902705681 scopus 로고    scopus 로고
    • Single cell mutational analysis of PIK3CA in circulating tumor cells and metastases in breast cancer reveals heterogeneity, discordance, and mutation persistence in cultured disseminated tumor cells from bone marrow
    • Deng G, Krishnakumar S, Powell AA, et al., Single cell mutational analysis of PIK3CA in circulating tumor cells and metastases in breast cancer reveals heterogeneity, discordance, and mutation persistence in cultured disseminated tumor cells from bone marrow. BMC Cancer 2014; 14: 456
    • (2014) BMC Cancer , vol.14 , pp. 456
    • Deng, G.1    Krishnakumar, S.2    Powell, A.A.3
  • 94
    • 84908084150 scopus 로고    scopus 로고
    • TP53 mutations detected in circulating tumor cells present in the blood of metastatic triple negative breast cancer patients
    • Fernandez SV, Bingham C, Fittipaldi P, et al., TP53 mutations detected in circulating tumor cells present in the blood of metastatic triple negative breast cancer patients. Breast Cancer Res 2014; 16: 445.
    • (2014) Breast Cancer Res , vol.16 , pp. 445
    • Fernandez, S.V.1    Bingham, C.2    Fittipaldi, P.3
  • 95
    • 84934323716 scopus 로고    scopus 로고
    • Short-term expansion of breast circulating cancer cells predicts response to anti-cancer therapy
    • Khoo BL, Lee SC, Kumar P, et al., Short-term expansion of breast circulating cancer cells predicts response to anti-cancer therapy. Oncotarget 2015;6(17):15578-93.
    • (2015) Oncotarget , vol.6 , Issue.17 , pp. 15578
    • Khoo, B.L.1    Lee, S.C.2    Kumar, P.3
  • 96
    • 84928698890 scopus 로고    scopus 로고
    • Establishment and characterization of a cell line from human circulating colon cancer cells
    • Cayrefourcq L, Mazard T, Joosse S, et al., Establishment and characterization of a cell line from human circulating colon cancer cells. Cancer Res 2015; 75: 892-901.
    • (2015) Cancer Res , vol.75 , pp. 892-901
    • Cayrefourcq, L.1    Mazard, T.2    Joosse, S.3
  • 97
    • 84859641038 scopus 로고    scopus 로고
    • Using gene expression noise to understand gene regulation
    • Munsky B, Neuert G, van Oudenaarden A., Using gene expression noise to understand gene regulation. Science 2012; 336: 183-7.
    • (2012) Science , vol.336 , pp. 183-187
    • Munsky, B.1    Neuert, G.2    Van Oudenaarden, A.3
  • 98
    • 84901831004 scopus 로고    scopus 로고
    • Validation of noise models for single-cell transcriptomics
    • Grun D, Kester L, van Oudenaarden A., Validation of noise models for single-cell transcriptomics. Nat Methods 2014; 11: 637-40.
    • (2014) Nat Methods , vol.11 , pp. 637-640
    • Grun, D.1    Kester, L.2    Van Oudenaarden, A.3
  • 99
    • 84856398949 scopus 로고    scopus 로고
    • Digital RNA sequencing minimizes sequence-dependent bias and amplification noise with optimized single-molecule barcodes
    • Shiroguchi K, Jia TZ, Sims PA, et al., Digital RNA sequencing minimizes sequence-dependent bias and amplification noise with optimized single-molecule barcodes. Proc Natl Acad Sci USA 2012; 109: 1347-52.
    • (2012) Proc Natl Acad Sci USA , vol.109 , pp. 1347-1352
    • Shiroguchi, K.1    Jia, T.Z.2    Sims, P.A.3
  • 100
    • 84944901262 scopus 로고    scopus 로고
    • Characterizing noise structure in single-cell RNA-seq distinguishes genuine from technical stochastic allelic expression
    • Kim JK, Kolodziejczyk AA, Illicic T, et al., Characterizing noise structure in single-cell RNA-seq distinguishes genuine from technical stochastic allelic expression. Nat Commun 2015; 6: 8687.
    • (2015) Nat Commun , vol.6 , pp. 8687
    • Kim, J.K.1    Kolodziejczyk, A.A.2    Illicic, T.3
  • 101
    • 80051967505 scopus 로고    scopus 로고
    • Stochastic state transitions give rise to phenotypic equilibrium in populations of cancer cells
    • Gupta PB, Fillmore CM, Jiang G, et al., Stochastic state transitions give rise to phenotypic equilibrium in populations of cancer cells. Cell 2011; 146: 633-44.
    • (2011) Cell , vol.146 , pp. 633-644
    • Gupta, P.B.1    Fillmore, C.M.2    Jiang, G.3
  • 102
    • 84868206265 scopus 로고    scopus 로고
    • Epigenetic polymorphism and the stochastic formation of differentially methylated regions in normal and cancerous tissues
    • Landan G, Cohen NM, Mukamel Z, et al., Epigenetic polymorphism and the stochastic formation of differentially methylated regions in normal and cancerous tissues. Nat Genet 2012; 44: 1207-14.
    • (2012) Nat Genet , vol.44 , pp. 1207-1214
    • Landan, G.1    Cohen, N.M.2    Mukamel, Z.3
  • 103
    • 84881477907 scopus 로고    scopus 로고
    • Batist Biopsies: Next-generation biospecimens for tailoring therapy
    • Basik M, Aguilar-Mahecha A, Rousseau C, et al., Batist Biopsies: Next-generation biospecimens for tailoring therapy. Nat Rev Clin Oncol 2013; 10: 437-50.
    • (2013) Nat Rev Clin Oncol , vol.10 , pp. 437-450
    • Basik, M.1    Aguilar-Mahecha, A.2    Rousseau, C.3
  • 104
    • 84907414338 scopus 로고    scopus 로고
    • Single-cell RNA sequencing identifies extracellular matrix gene expression by pancreatic circulating tumor cells. Cell
    • Ting DT, Wittner BS, Ligorio M, et al., Single-cell RNA sequencing identifies extracellular matrix gene expression by pancreatic circulating tumor cells. Cell Rep 2014; 8: 1905-18.
    • (2014) Rep , vol.8 , pp. 1905-1918
    • Ting, D.T.1    Wittner, B.S.2    Ligorio, M.3
  • 105
    • 0036595629 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transitions in tumour progression
    • Thiery JP., Epithelial-mesenchymal transitions in tumour progression. Nat Rev Cancer 2002; 2: 442-54.
    • (2002) Nat Rev Cancer , vol.2 , pp. 442-454
    • Thiery, J.P.1
  • 106
    • 84877726784 scopus 로고    scopus 로고
    • The identification and characterization of breast cancer CTCs competent for brain metastasis
    • Zhang L, Ridgway LD, Wetzel MD, et al., The identification and characterization of breast cancer CTCs competent for brain metastasis. Sci Transl Med 2013; 5: 180ra48.
    • (2013) Sci Transl Med , vol.5 , pp. 180ra48
    • Zhang, L.1    Ridgway, L.D.2    Wetzel, M.D.3
  • 107
    • 84925031191 scopus 로고    scopus 로고
    • Methods of integrating data to uncover genotype-phenotype interactions
    • Ritchie MD, Holzinger ER, Li R, et al., Methods of integrating data to uncover genotype-phenotype interactions. Nat Rev Genet 2015; 16: 85-97.
    • (2015) Nat Rev Genet , vol.16 , pp. 85-97
    • Ritchie, M.D.1    Holzinger, E.R.2    Li, R.3
  • 108
    • 84947613905 scopus 로고    scopus 로고
    • Human genotype-phenotype databases: Aims, challenges and opportunities
    • Brookes AJ, Robinson PN., Human genotype-phenotype databases: aims, challenges and opportunities. Nat Rev Genet 2015; 16: 702-15.
    • (2015) Nat Rev Genet , vol.16 , pp. 702-715
    • Brookes, A.J.1    Robinson, P.N.2
  • 110
    • 80455173836 scopus 로고    scopus 로고
    • Nanopore sensors for nucleic acid analysis
    • Venkatesan BM, Bashir R., Nanopore sensors for nucleic acid analysis. Nat Nanotechnol 2011; 6: 615-24.
    • (2011) Nat Nanotechnol , vol.6 , pp. 615-624
    • Venkatesan, B.M.1    Bashir, R.2
  • 111
    • 84926472171 scopus 로고    scopus 로고
    • Improved data analysis for the MinION nanopore sequencer
    • Jain M, Fiddes IT, Miga KH, et al., Improved data analysis for the MinION nanopore sequencer. Nat Methods 2015; 12: 351-6.
    • (2015) Nat Methods , vol.12 , pp. 351-356
    • Jain, M.1    Fiddes, I.T.2    Miga, K.H.3
  • 112
    • 33847402612 scopus 로고    scopus 로고
    • Detection of circulating tumor cells in peripheral blood of patients with metastatic breast cancer: A validation study of the CellSearch system
    • Riethdorf S, Fritsche H, Muller V, et al., Detection of circulating tumor cells in peripheral blood of patients with metastatic breast cancer: a validation study of the CellSearch system. Clin Cancer Res 2007; 13: 920-8.
    • (2007) Clin Cancer Res , vol.13 , pp. 920-928
    • Riethdorf, S.1    Fritsche, H.2    Muller, V.3
  • 113
    • 4143094988 scopus 로고    scopus 로고
    • Circulating tumor cells, disease progression, and survival in metastatic breast cancer
    • Cristofanilli M, Budd GT, Ellis MJ, et al., Circulating tumor cells, disease progression, and survival in metastatic breast cancer. N Engl J Med 2004; 351: 781-91.
    • (2004) N Engl J Med , vol.351 , pp. 781-791
    • Cristofanilli, M.1    Budd, G.T.2    Ellis, M.J.3
  • 114
    • 20144385756 scopus 로고    scopus 로고
    • Circulating tumor cells: A novel prognostic factor for newly diagnosed metastatic breast cancer
    • Cristofanilli M, Hayes DF, Budd GT, et al., Circulating tumor cells: a novel prognostic factor for newly diagnosed metastatic breast cancer. J Clin Oncol 2005; 23: 1420-30.
    • (2005) J Clin Oncol , vol.23 , pp. 1420-1430
    • Cristofanilli, M.1    Hayes, D.F.2    Budd, G.T.3
  • 115
    • 67650762824 scopus 로고    scopus 로고
    • Super resolution fluorescence microscopy
    • Huang B, Bates M, Zhuang X., Super resolution fluorescence microscopy. Annu Rev Biochem 2009; 78: 993-1016.
    • (2009) Annu Rev Biochem , vol.78 , pp. 993-1016
    • Huang, B.1    Bates, M.2    Zhuang, X.3
  • 116
    • 55749093996 scopus 로고    scopus 로고
    • Network inference using informative priors
    • Mukherjee S, Speed TP., Network inference using informative priors. Proc Natl Acad Sci USA 2008; 105: 14313-8.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 14313-14318
    • Mukherjee, S.1    Speed, T.P.2
  • 117
    • 4043141477 scopus 로고    scopus 로고
    • Quantitative cancer proteomics: Stable isotope labeling with amino acids in cell culture (SILAC) as a tool for prostate cancer research
    • Everley PA, Krijgsveld J, Zetter BR, et al., Quantitative cancer proteomics: stable isotope labeling with amino acids in cell culture (SILAC) as a tool for prostate cancer research. Mol Cell Proteomic 2004; 3: 729-35.
    • (2004) Mol Cell Proteomic , vol.3 , pp. 729-735
    • Everley, P.A.1    Krijgsveld, J.2    Zetter, B.R.3
  • 119
    • 84883027282 scopus 로고    scopus 로고
    • Detection of Circulating Tumor Cells Harboring a Unique ALK Rearrangement in ALK-Positive Non-Small-Cell Lung Cancer
    • Pailler E, Julien A, Amélie B, et al., Detection of Circulating Tumor Cells Harboring a Unique ALK Rearrangement in ALK-Positive Non-Small-Cell Lung Cancer. JCO 2013; 31: 2273-81.
    • (2013) JCO , vol.31 , pp. 2273-2281
    • Pailler, E.1    Julien, A.2    Amélie, B.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.