Single cell mutational analysis of PIK3CA in circulating tumor cells and metastases in breast cancer reveals heterogeneity, discordance, and mutation persistence in cultured disseminated tumor cells from bone marrow

BMC Cancer

Volumn 14, Issue 1, 2014, Pages

  Deng, Glenn ^a,b   Krishnakumar, Sujatha ^b   Powell, Ashley A ^b   Zhang, Haiyu ^b   Mindrinos, Michael N ^b   Telli, Melinda L ^b   Davis, Ronald W ^b   Jeffrey, Stefanie S ^b  

^a WUHAN DONGHU UNIVERSITY   (China)

^b STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Cancer cell culture; Circulating tumor cells (CTCs); Disseminated tumor cells (DTCs); Heterogeneity; Mutation analysis; PIK3CA; Single cell analysis

Indexed keywords

CAPECITABINE; CYCLOPHOSPHAMIDE; EVEROLIMUS; EXEMESTANE; FULVESTRANT; TAMOXIFEN; PHOSPHATIDYLINOSITOL 3 KINASE; PIK3CA PROTEIN, HUMAN;

ARTICLE; BONE MARROW CELL; BREAST CANCER; CELL ISOLATION; CELL VIABILITY; CIRCULATING TUMOR CELL; CLINICAL ARTICLE; CONTROLLED STUDY; EPITHELIAL MESENCHYMAL TRANSITION; FEMALE; GENE AMPLIFICATION; GENE MUTATION; GENE SEQUENCE; GENETIC HETEROGENEITY; GENOTYPE; HUMAN; HUMAN CELL; HUMAN TISSUE; METASTASIS; MORPHOLOGY; MUTATIONAL ANALYSIS; ONCOGENE; PIK3CA GENE; POLYMERASE CHAIN REACTION; BONE MARROW; BREAST TUMOR; EXON; GENETICS; METABOLISM; MUTATION; NUCLEOTIDE SEQUENCE; PATHOLOGY; PROCEDURES; SINGLE CELL ANALYSIS; TUMOR EMBOLISM;

BONE MARROW; BREAST NEOPLASMS; DNA MUTATIONAL ANALYSIS; EXONS; FEMALE; HUMANS; MUTATION; NEOPLASM METASTASIS; NEOPLASTIC CELLS, CIRCULATING; PHOSPHATIDYLINOSITOL 3-KINASES; SINGLE-CELL ANALYSIS;

EID: 84902705681     PISSN: None     EISSN: 14712407     Source Type: Journal    
DOI: 10.1186/1471-2407-14-456     Document Type: Article

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