-
1
-
-
0017704436
-
Metastasis results from preexisting variant cells within a malignant tumor
-
Fidler, I. J. & Kripke, M. L. Metastasis results from preexisting variant cells within a malignant tumor. Science 197, 893-895 (1977). (Pubitemid 8168759)
-
(1977)
Science
, vol.197
, Issue.4306
, pp. 893-895
-
-
Fidler, I.J.1
Kripke, M.L.2
-
2
-
-
80054686286
-
Tumor metastasis: Molecular insights and evolving paradigms
-
Valastyan, S. & Weinberg, R. A. Tumor metastasis: molecular insights and evolving paradigms. Cell 147, 275-292 (2011).
-
(2011)
Cell
, vol.147
, pp. 275-292
-
-
Valastyan, S.1
Weinberg, R.A.2
-
3
-
-
66249136447
-
Non-genetic origins of cell-to-cell variability in TRAIL-induced apoptosis
-
Spencer, S. L., Gaudet, S., Albeck, J. G., Burke, J. M. & Sorger, P. K. Non-genetic origins of cell-to-cell variability in TRAIL-induced apoptosis. Nature 459, 428-432 (2009).
-
(2009)
Nature
, vol.459
, pp. 428-432
-
-
Spencer, S.L.1
Gaudet, S.2
Albeck, J.G.3
Burke, J.M.4
Sorger, P.K.5
-
4
-
-
57349097152
-
Dynamic proteomics of individual cancer cells in response to a drug
-
Cohen, A. A. et al. Dynamic proteomics of individual cancer cells in response to a drug. Science 322, 1511-1516 (2008).
-
(2008)
Science
, vol.322
, pp. 1511-1516
-
-
Cohen, A.A.1
-
5
-
-
77950809059
-
A chromatin-mediated reversible drug-tolerant state in cancer cell subpopulations
-
Sharma, S. V. et al. A chromatin-mediated reversible drug-tolerant state in cancer cell subpopulations. Cell 141, 69-80 (2010).
-
(2010)
Cell
, vol.141
, pp. 69-80
-
-
Sharma, S.V.1
-
6
-
-
77951728283
-
Intravital imaging illuminates transforming growth factor beta signaling switches during metastasis
-
Giampieri, S., Pinner, S. & Sahai, E. Intravital imaging illuminates transforming growth factor beta signaling switches during metastasis. Cancer Res. 70, 3435-3439 (2010).
-
(2010)
Cancer Res
, vol.70
, pp. 3435-3439
-
-
Giampieri, S.1
Pinner, S.2
Sahai, E.3
-
7
-
-
84860171972
-
Cell biology. Using cell-to-cell variability - A new era in molecular biology
-
Pelkmans, L. Cell biology. Using cell-to-cell variability - a new era in molecular biology. Science 336, 425-426 (2012).
-
(2012)
Science
, vol.336
, pp. 425-426
-
-
Pelkmans, L.1
-
8
-
-
75549087566
-
Heterogeneity in the physiological states and pharmacological responses of differentiating 3T3-L1 preadipocytes
-
Loo, L. H. et al. Heterogeneity in the physiological states and pharmacological responses of differentiating 3T3-L1 preadipocytes. J. Cell Biol. 187, 375-384 (2009).
-
(2009)
J. Cell Biol
, vol.187
, pp. 375-384
-
-
Loo, L.H.1
-
9
-
-
79651474934
-
Cell-to-cell variability in PI3K protein level regulates PI3K-AKT pathway activity in cell populations
-
Yuan, T. L., Wulf, G., Burga, L. & Cantley, L. C. Cell-to-cell variability in PI3K protein level regulates PI3K-AKT pathway activity in cell populations. Curr. Biol. 21, 173-183 (2011).
-
(2011)
Curr. Biol
, vol.21
, pp. 173-183
-
-
Yuan, T.L.1
Wulf, G.2
Burga, L.3
Cantley, L.C.4
-
10
-
-
32444435330
-
Parallel picoliter RT-PCR assays using microfluidics
-
DOI 10.1021/ac0513865
-
Marcus, J. S., Anderson, W. F. & Quake, S. R. Parallel picoliter rt-PCR assays using microfluidics. Anal. Chem. 78, 956-958 (2006). (Pubitemid 43228605)
-
(2006)
Analytical Chemistry
, vol.78
, Issue.3
, pp. 956-958
-
-
Marcus, J.S.1
Anderson, W.F.2
Quake, S.R.3
-
11
-
-
70549112929
-
Performance of nanoliter-sized droplet-based microfluidic PCR
-
Wang, F. & Burns, M. A. Performance of nanoliter-sized droplet-based microfluidic PCR. Biomed. Microdevices 11, 1071-1080 (2009).
-
(2009)
Biomed. Microdevices
, vol.11
, pp. 1071-1080
-
-
Wang, F.1
Burns, M.A.2
-
12
-
-
77956116622
-
Massively parallel detection of gene expression in single cells using subnanolitre wells
-
Gong, Y., Ogunniyi, A. O. & Love, J. C. Massively parallel detection of gene expression in single cells using subnanolitre wells. Lab. Chip. 10, 2334-2337 (2010).
-
(2010)
Lab. Chip
, vol.10
, pp. 2334-2337
-
-
Gong, Y.1
Ogunniyi, A.O.2
Love, J.C.3
-
13
-
-
77956412152
-
Tracing the derivation of embryonic stem cells from the inner cell mass by single-cell RNA-Seq analysis
-
Tang, F. et al. Tracing the derivation of embryonic stem cells from the inner cell mass by single-cell RNA-Seq analysis. Cell Stem Cell 6, 468-478 (2010).
-
(2010)
Cell Stem Cell
, vol.6
, pp. 468-478
-
-
Tang, F.1
-
14
-
-
80052174976
-
High-throughput microfluidic single-cell RT-qPCR
-
White, A. K. et al. High-throughput microfluidic single-cell RT-qPCR. Proc. Natl Acad. Sci. USA 108, 13999-14004 (2011).
-
(2011)
Proc. Natl Acad. Sci. USA
, vol.108
, pp. 13999-14004
-
-
White, A.K.1
-
15
-
-
84862676726
-
A deep profiler's guide to cytometry
-
Bendall, S. C., Nolan, G. P., Roederer, M. & Chattopadhyay, P. K. A deep profiler's guide to cytometry. Trends. Immunol. 33, 323-332 (2012).
-
(2012)
Trends. Immunol
, vol.33
, pp. 323-332
-
-
Bendall, S.C.1
Nolan, G.P.2
Roederer, M.3
Chattopadhyay, P.K.4
-
16
-
-
0035943677
-
Regulation of Akt/PKB activation by tyrosine phosphorylation
-
Chen, R. et al. Regulation of Akt/PKB activation by tyrosine phosphorylation. J. Biol. Chem. 276, 31858-31862 (2001).
-
(2001)
J. Biol. Chem
, vol.276
, pp. 31858-31862
-
-
Chen, R.1
-
17
-
-
33846316306
-
Quantitative analysis of Akt phosphorylation and activity in response to EGF and insulin treatment
-
DOI 10.1016/j.bbrc.2006.12.188, PII S0006291X06027367
-
Kumar, N., Afeyan, R., Sheppard, S., Harms, B. & Lauffenburger, D. A. Quantitative analysis of Akt phosphorylation and activity in response to EGF and insulin treatment. Biochem. Biophys. Res. Commun. 354, 14-20 (2007). (Pubitemid 46123191)
-
(2007)
Biochemical and Biophysical Research Communications
, vol.354
, Issue.1
, pp. 14-20
-
-
Kumar, N.1
Afeyan, R.2
Sheppard, S.3
Harms, B.4
Lauffenburger, D.A.5
-
18
-
-
27644496624
-
A compendium of signals and responses triggered by prodeath and prosurvival cytokines
-
DOI 10.1074/mcp.M500158-MCP200
-
Gaudet, S. et al. A compendium of signals and responses triggered by prodeath and prosurvival cytokines. Mol. Cell Proteomics 4, 1569-1590 (2005). (Pubitemid 41555481)
-
(2005)
Molecular and Cellular Proteomics
, vol.4
, Issue.10
, pp. 1569-1590
-
-
Gaudet, S.1
Janes, K.A.2
Albeck, J.G.3
Pace, E.A.4
Lauffenburger, D.A.5
Sorger, P.K.6
-
19
-
-
34548379387
-
Processive phosphorylation: Mechanism and biological importance
-
DOI 10.1016/j.cellsig.2007.06.006, PII S0898656807001817
-
Patwardhan, P. & Miller, W. T. Processive phosphorylation: mechanism and biological importance. Cell. Signal. 19, 2218-2226 (2007). (Pubitemid 47361682)
-
(2007)
Cellular Signalling
, vol.19
, Issue.11
, pp. 2218-2226
-
-
Patwardhan, P.1
Miller, W.T.2
-
20
-
-
84856004321
-
Single-cell proteomic chip for profiling intracellular signaling pathways in single tumor cells
-
Shi, Q. et al. Single-cell proteomic chip for profiling intracellular signaling pathways in single tumor cells. Proc. Natl Acad. Sci. USA 109, 419-424 (2012).
-
(2012)
Proc. Natl Acad. Sci. USA
, vol.109
, pp. 419-424
-
-
Shi, Q.1
-
21
-
-
79954682695
-
Measuring enzyme activity in single cells
-
Kovarik, M. L. & Allbritton, N. L. Measuring enzyme activity in single cells. Trends. Biotechnol. 29, 222-230 (2011).
-
(2011)
Trends. Biotechnol
, vol.29
, pp. 222-230
-
-
Kovarik, M.L.1
Allbritton, N.L.2
-
22
-
-
0034059309
-
Measurement of kinase activation in single mammalian cells
-
DOI 10.1038/73760
-
Meredith, G. D., Sims, C. E., Soughayer, J. S. & Allbritton, N. L. Measurement of kinase activation in single mammalian cells. Nat. Biotechnol. 18, 309-312 (2000). (Pubitemid 30159483)
-
(2000)
Nature Biotechnology
, vol.18
, Issue.3
, pp. 309-312
-
-
Meredith, G.D.1
Sims, C.E.2
Soughayer, J.S.3
Allbritton, N.L.4
-
23
-
-
79959451416
-
Reporting from the field: Genetically encoded fluorescent reporters uncover signaling dynamics in living biological systems
-
Mehta, S. & Zhang, J. Reporting from the field: genetically encoded fluorescent reporters uncover signaling dynamics in living biological systems. Annu. Rev. Biochem. 80, 375-401 (2011).
-
(2011)
Annu. Rev. Biochem
, vol.80
, pp. 375-401
-
-
Mehta, S.1
Zhang, J.2
-
24
-
-
84860468362
-
Live-cell fluorescence microscopy with molecular biosensors: What are we really measuring?
-
Haugh, J. M. Live-cell fluorescence microscopy with molecular biosensors: what are we really measuring? Biophys. J. 102, 2003-2011 (2012).
-
(2012)
Biophys J.
, vol.102
, pp. 2003-2011
-
-
Haugh, J.M.1
-
25
-
-
18744408814
-
A multiplexed homogeneous fluorescence-based assay for protein kinase activity in cell lysates
-
DOI 10.1038/nmeth747
-
Shults, M. D., Janes, K. A., Lauffenburger, D. A. & Imperiali, B. A multiplexed homogeneous fluorescence-based assay for protein kinase activity in cell lysates. Nat. Methods 2, 277-283 (2005). (Pubitemid 41131009)
-
(2005)
Nature Methods
, vol.2
, Issue.4
, pp. 277-283
-
-
Shults, M.D.1
Janes, K.A.2
Lauffenburger, D.A.3
Imperiali, B.4
-
26
-
-
68049099384
-
Microfluidic concentration-enhanced cellular kinase activity assay
-
Lee, J. H., Cosgrove, B. D., Lauffenburger, D. A. & Han, J. Microfluidic concentration-enhanced cellular kinase activity assay. J. Am. Chem. Soc. 131, 10340-10341 (2009).
-
(2009)
J. Am. Chem. Soc
, vol.131
, pp. 10340-10341
-
-
Lee, J.H.1
Cosgrove, B.D.2
Lauffenburger, D.A.3
Han, J.4
-
27
-
-
23244464794
-
Multipurpose microfluidic probe
-
Juncker, D., Schmid, H. & Delamarche, E. Multipurpose microfluidic probe. Nat. Mater. 4, 622-628 (2005).
-
(2005)
Nat. Mater
, vol.4
, pp. 622-628
-
-
Juncker, D.1
Schmid, H.2
Delamarche, E.3
-
28
-
-
77952970077
-
A microfluidic pipette for single-cell pharmacology
-
Ainla, A., Jansson, E. T., Stepanyants, N., Orwar, O. & Jesorka, A. A microfluidic pipette for single-cell pharmacology. Anal. Chem. 82, 4529-4536 (2010).
-
(2010)
Anal. Chem
, vol.82
, pp. 4529-4536
-
-
Ainla, A.1
Jansson, E.T.2
Stepanyants, N.3
Orwar, O.4
Jesorka, A.5
-
29
-
-
52449096942
-
Recognition-domain focused chemosensors: Versatile and efficient reporters of protein kinase activity
-
Lukovic, E., Gonzalez-Vera, J. A. & Imperiali, B. Recognition-domain focused chemosensors: versatile and efficient reporters of protein kinase activity. J. Am. Chem. Soc. 130, 12821-12827 (2008).
-
(2008)
J. Am. Chem. Soc
, vol.130
, pp. 12821-12827
-
-
Lukovic, E.1
Gonzalez-Vera, J.A.2
Imperiali, B.3
-
30
-
-
79251482450
-
A p38alpha-selective chemosensor for use in unfractionated cell lysates
-
Stains, C. I., Lukovic, E. & Imperiali, B. A p38alpha-selective chemosensor for use in unfractionated cell lysates. ACS Chem. Biol. 6, 101-105 (2011).
-
(2011)
ACS Chem. Biol
, vol.6
, pp. 101-105
-
-
Stains, C.I.1
Lukovic, E.2
Imperiali, B.3
-
31
-
-
84868136554
-
An integrated microfluidic probe for concentration-enhanced selective single cell kinase activity measurement
-
Seattle
-
Sarkar, A., Kolitz, S., Cheow, L. F., Lauffenburger, D. A. & Han, J. An integrated microfluidic probe for concentration-enhanced selective single cell kinase activity measurement. 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences (mTAS 2011), Seattle (2011).
-
(2011)
15th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MTAS 2011)
-
-
Sarkar, A.1
Kolitz, S.2
Cheow, L.F.3
Lauffenburger, D.A.4
Han, J.5
-
32
-
-
33845257870
-
Variability and memory of protein levels in human cells
-
DOI 10.1038/nature05316, PII NATURE05316
-
Sigal, A. et al. Variability and memory of protein levels in human cells. Nature 444, 643-646 (2006). (Pubitemid 44864444)
-
(2006)
Nature
, vol.444
, Issue.7119
, pp. 643-646
-
-
Sigal, A.1
Milo, R.2
Cohen, A.3
Geva-Zatorsky, N.4
Klein, Y.5
Liron, Y.6
Rosenfeld, N.7
Danon, T.8
Perzov, N.9
Alon, U.10
-
33
-
-
25844433114
-
Gene expression profiling in single cells from the pancreatic islets of Langerhans reveals lognormal distribution of mRNA levels
-
DOI 10.1101/gr.3820805
-
Bengtsson, M., Stahlberg, A., Rorsman, P. & Kubista, M. Gene expression profiling in single cells from the pancreatic islets of Langerhans reveals lognormal distribution of mRNA levels. Genome Res. 15, 1388-1392 (2005). (Pubitemid 41400905)
-
(2005)
Genome Research
, vol.15
, Issue.10
, pp. 1388-1392
-
-
Bengtsson, M.1
Stahlberg, A.2
Rorsman, P.3
Kubista, M.4
-
35
-
-
84874709677
-
Modulation of CYP3A4 activity and induction of apoptosis, necrosis and senescence by the anti-tumour imidazoacridinone C-1311 in human hepatoma cells
-
Augustin, E., Pawlowska, M., Polewska, J., Potega, A. & Mazerska, Z. Modulation of CYP3A4 activity and induction of apoptosis, necrosis and senescence by the anti-tumour imidazoacridinone C-1311 in human hepatoma cells. Cell Biol. Int. 37, 109-120 (2013).
-
(2013)
Cell Biol. Int
, vol.37
, pp. 109-120
-
-
Augustin, E.1
Pawlowska, M.2
Polewska, J.3
Potega, A.4
Mazerska, Z.5
-
36
-
-
78349257844
-
The essence of senescence
-
Kuilman, T., Michaloglou, C., Mooi, W. J. & Peeper, D. S. The essence of senescence. Genes Dev. 24, 2463-2479 (2010).
-
(2010)
Genes Dev
, vol.24
, pp. 2463-2479
-
-
Kuilman, T.1
Michaloglou, C.2
Mooi, W.J.3
Peeper, D.S.4
-
37
-
-
33845292259
-
A negative feedback signaling network underlies oncogene-induced senescence
-
DOI 10.1016/j.ccr.2006.10.003, PII S1535610806002893
-
Courtois-Cox, S. et al. A negative feedback signaling network underlies oncogene-induced senescence. Cancer Cell 10, 459-472 (2006). (Pubitemid 44872980)
-
(2006)
Cancer Cell
, vol.10
, Issue.6
, pp. 459-472
-
-
Courtois-Cox, S.1
Genther Williams, S.M.2
Reczek, E.E.3
Johnson, B.W.4
McGillicuddy, L.T.5
Johannessen, C.M.6
Hollstein, P.E.7
MacCollin, M.8
Cichowski, K.9
-
38
-
-
0035116179
-
Down-regulation of Akt/PKB in senescent cardiac fibroblasts impairs PDGF-induced cell proliferation
-
DOI 10.1016/S0008-6363(00)00296-0, PII S0008636300002960
-
Diez, C. et al. Down-regulation of Akt/PKB in senescent cardiac fibroblasts impairs PDGF-induced cell proliferation. Cardiovasc. Res. 49, 731-740 (2001). (Pubitemid 32178376)
-
(2001)
Cardiovascular Research
, vol.49
, Issue.4
, pp. 731-740
-
-
Diez, C.1
Nestler, M.2
Friedrich, U.3
Vieth, M.4
Stolte, M.5
Hu, K.6
Hoppe, J.7
Simm, A.8
-
39
-
-
3242813768
-
Senescence marker protein-30 regulates Akt activity and contributes to cell survival in Hep G2 cells
-
DOI 10.1016/j.bbrc.2004.06.161, PII S0006291X04014135
-
Matsuyama, S. et al. Senescence marker protein-30 regulates Akt activity and contributes to cell survival in Hep G2 cells. Biochem. Biophys. Res. Commun. 321, 386-390 (2004). (Pubitemid 39055758)
-
(2004)
Biochemical and Biophysical Research Communications
, vol.321
, Issue.2
, pp. 386-390
-
-
Matsuyama, S.1
Kitamura, T.2
Enomoto, N.3
Fujita, T.4
Ishigami, A.5
Handa, S.6
Maruyama, N.7
Zheng, D.8
Ikejima, K.9
Takei, Y.10
Sato, N.11
-
40
-
-
34248586312
-
Coordinated regulation of pathways for enhanced cell motility and chemotaxis is conserved in rat and mouse mammary tumors
-
DOI 10.1158/0008-5472.CAN-06-3714
-
Wang, W. et al. Coordinated regulation of pathways for enhanced cell motility and chemotaxis is conserved in rat and mouse mammary tumors. Cancer Res. 67, 3505-3511 (2007). (Pubitemid 46762128)
-
(2007)
Cancer Research
, vol.67
, Issue.8
, pp. 3505-3511
-
-
Wang, W.1
Wyckoff, J.B.2
Goswami, S.3
Wang, Y.4
Sidani, M.5
Segall, J.E.6
Condeelis, J.S.7
-
41
-
-
0034615958
-
Monolithic microfabricated valves and pumps by multilayer soft lithography
-
DOI 10.1126/science.288.5463.113
-
Unger, M. A., Chou, H. P., Thorsen, T., Scherer, A. & Quake, S. R. Monolithic microfabricated valves and pumps by multilayer soft lithography. Science 288, 113-116 (2000). (Pubitemid 30203039)
-
(2000)
Science
, vol.288
, Issue.5463
, pp. 113-116
-
-
Unger, M.A.1
Chou, H.-P.2
Thorsen, T.3
Scherer, A.4
Quake, S.R.5
-
42
-
-
66149114307
-
Plastic masters-rigid templates for soft lithography
-
Desai, S. P., Freeman, D. M. & Voldman, J. Plastic masters-rigid templates for soft lithography. Lab. Chip. 9, 1631-1637 (2009).
-
(2009)
Lab. Chip
, vol.9
, pp. 1631-1637
-
-
Desai, S.P.1
Freeman, D.M.2
Voldman, J.3
|