RNA-Seq of single prostate CTCs implicates noncanonical Wnt signaling in antiandrogen resistance

Science

Volumn 349, Issue 6254, 2015, Pages 1351-1356

  Miyamoto, David T ^a   Zheng, Yu ^a,b   Wittner, Ben S ^a   Lee, Richard J ^a   Zhu, Huili ^a   Broderick, Katherine T ^a   Desai, Rushil ^a   Fox, Douglas B ^a   Brannigan, Brian W ^a   Trautwein, Julie ^a   Arora, Kshitij S ^a   Desai, Niyati ^a   Dahl, Douglas M ^a   Sequist, Lecia V ^a   Smith, Matthew R ^a   Kapur, Ravi ^a   Wu, Chin Lee ^a   Shioda, Toshi ^a   Ramaswamy, Sridhar ^a   Ting, David T ^a   Toner, Mehmet ^a   Maheswaran, Shyamala ^a   Haber, Daniel A ^a,b   more..

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIANDROGEN; MESSENGER RNA; RNA; WNT PROTEIN; ANDROGEN RECEPTOR; ENZALUTAMIDE; ONCOPROTEIN; PHENYLTHIOHYDANTOIN; TRANSCRIPTOME; WNT5A PROTEIN, HUMAN;

ANDROGEN; CANCER; CELLS AND CELL COMPONENTS; DRUG RESISTANCE; HETEROGENEITY; MUTATION; RNA; TUMOR;

ARTICLE; CELL PROLIFERATION; CIRCULATING TUMOR CELL; CLINICAL ARTICLE; CONTROLLED STUDY; GENE EXPRESSION REGULATION; GENE MUTATION; HUMAN; HUMAN CELL; IN SITU HYBRIDIZATION; MALE; PRIORITY JOURNAL; PROSTATE CANCER; PROSTATE CANCER CELL LINE; PROTEIN EXPRESSION; RNA SEQUENCE; RNA SPLICING; SINGLE CELL ANALYSIS; WNT SIGNALING PATHWAY; ANALOGS AND DERIVATIVES; ANIMAL; DRUG EFFECTS; DRUG RESISTANCE; DRUG SCREENING; GENETICS; METABOLISM; MOUSE; PATHOLOGY; PROCEDURES; PROSTATE; PROSTATIC NEOPLASMS; SEQUENCE ANALYSIS; SIGNAL TRANSDUCTION; TUMOR CELL LINE; TUMOR EMBOLISM;

ANDROGEN ANTAGONISTS; ANIMALS; CELL LINE, TUMOR; DRUG RESISTANCE, NEOPLASM; HUMANS; MALE; MICE; NEOPLASTIC CELLS, CIRCULATING; PHENYLTHIOHYDANTOIN; PROSTATE; PROSTATIC NEOPLASMS; PROTO-ONCOGENE PROTEINS; RECEPTORS, ANDROGEN; RNA SPLICING; SEQUENCE ANALYSIS, RNA; SIGNAL TRANSDUCTION; SINGLE-CELL ANALYSIS; TRANSCRIPTOME; WNT PROTEINS; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84942904757     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.aab0917     Document Type: Article

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