Single-cell analyses of transcriptional heterogeneity during drug tolerance transition in cancer cells by RNA sequencing

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 44, 2014, Pages E4726-E4735

  Lee, Mei Chong Wendy ^a   Lopez Diaz, Ferno J ^b   Khan, Shahid Yar ^a,d   Tariq, Muhammad Akram ^a,e   Dayn, Yelena ^b   Vaske, CharlesJoseph ^c   Radenbaugh, AmieJ ^a   Kim, Hyunsung John ^a   Emerson, Beverly M ^b   Pourm, Nader ^a  

^a University of California Santa Cruz   (United States)

^b SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

^c Five3 Genomics   (United States)

^d JOHNS HOPKINS UNIVERSITY   (United States)

^e KING EDWARD MEDICAL UNIVERSITY   (Pakistan)

Author keywords

Drug resistance |; Paclitaxel |; RNA Seq; Single cell |; Tumor heterogeniety |

Indexed keywords

GENOMIC DNA; PACLITAXEL; RNA POLYMERASE; TRANSCRIPTOME; ANTINEOPLASTIC AGENT; RNA;

APOPTOSIS; ARTICLE; CANCER CELL; CELL ADHESION; CELL GROWTH; CELL ISOLATION; CELL STRESS; CELL SURFACE; CONTROLLED STUDY; DNA SEQUENCE; DRUG EXPOSURE; DRUG TOLERANCE; EMBRYO; GENE EXPRESSION PROFILING; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; MICROTUBULE; MISSENSE MUTATION; PYROSEQUENCING; RNA EDITING; RNA SEQUENCE; SEQUENCE ANALYSIS; SINGLE CELL ANALYSIS; UPREGULATION; BIOSYNTHESIS; BREAST NEOPLASMS; DRUG EFFECTS; DRUG RESISTANCE; FEMALE; GENETIC TRANSCRIPTION; GENETICS; METABOLISM; PATHOLOGY; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; BREAST NEOPLASMS; CELL LINE, TUMOR; DRUG RESISTANCE, NEOPLASM; FEMALE; HUMANS; PACLITAXEL; RNA, NEOPLASM; SEQUENCE ANALYSIS, RNA; TRANSCRIPTION, GENETIC;

EID: 84914706587     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1404656111     Document Type: Article

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