메뉴 건너뛰기




Volumn 468, Issue 3, 2016, Pages 443-453

Cellular functions of TMEM16/anoctamin

Author keywords

Anoctamin; Ca2+ activated Cl channel; Cl secretion; Nociception; Proliferation; Scramblase; TMEM16; Tumorigenesis

Indexed keywords

ANOCTAMIN; CALCIUM CHANNEL T TYPE; CALCIUM CHLORIDE; UNCLASSIFIED DRUG; CALCIUM; CHLORIDE; CHLORIDE CHANNEL;

EID: 84957940172     PISSN: 00316768     EISSN: 14322013     Source Type: Journal    
DOI: 10.1007/s00424-016-1790-0     Document Type: Review
Times cited : (139)

References (120)
  • 1
    • 84948732003 scopus 로고    scopus 로고
    • Intracellular sphingosine kinase 2-derived sphingosine-1-phosphate mediates epidermal growth factor-induced ezrin-radixin-moesin phosphorylation and cancer cell invasion
    • PID: 26209696
    • Adada MM, Canals D, Jeong N, Kelkar AD, Hernandez-Corbacho M, Pulkoski-Gross MJ, Donaldson JC, Hannun YA, Obeid LM (2015) Intracellular sphingosine kinase 2-derived sphingosine-1-phosphate mediates epidermal growth factor-induced ezrin-radixin-moesin phosphorylation and cancer cell invasion. FASEB J 29:4654–4669
    • (2015) FASEB J , vol.29 , pp. 4654-4669
    • Adada, M.M.1    Canals, D.2    Jeong, N.3    Kelkar, A.D.4    Hernandez-Corbacho, M.5    Pulkoski-Gross, M.J.6    Donaldson, J.C.7    Hannun, Y.A.8    Obeid, L.M.9
  • 2
    • 84861483800 scopus 로고    scopus 로고
    • Discovered on gastrointestinal stromal tumour 1 (DOG1): a useful immunohistochemical marker for diagnosing chondroblastoma
    • PID: 22335248
    • Akpalo H, Lange C, Zustin J (2012) Discovered on gastrointestinal stromal tumour 1 (DOG1): a useful immunohistochemical marker for diagnosing chondroblastoma. Histopathology 60:1099–1106
    • (2012) Histopathology , vol.60 , pp. 1099-1106
    • Akpalo, H.1    Lange, C.2    Zustin, J.3
  • 3
    • 0025005587 scopus 로고
    • Characteristics of chloride currents activated by noradrenaline in rabbit ear artery cells
    • PID: 1700110
    • Amedee T, Large WA, Wang Q (1990) Characteristics of chloride currents activated by noradrenaline in rabbit ear artery cells. J Physiol 428:501–516
    • (1990) J Physiol , vol.428 , pp. 501-516
    • Amedee, T.1    Large, W.A.2    Wang, Q.3
  • 4
    • 0037115674 scopus 로고    scopus 로고
    • Impact of epidermal growth factor receptor expression on survival and pattern of relapse in patients with advanced head and neck carcinoma
    • PID: 12499279
    • Ang KK, Berkey BA, Tu X, Zhang HZ, Katz R, Hammond EH, Fu KK, Milas L (2002) Impact of epidermal growth factor receptor expression on survival and pattern of relapse in patients with advanced head and neck carcinoma. Cancer Res 62:7350–7356
    • (2002) Cancer Res , vol.62 , pp. 7350-7356
    • Ang, K.K.1    Berkey, B.A.2    Tu, X.3    Zhang, H.Z.4    Katz, R.5    Hammond, E.H.6    Fu, K.K.7    Milas, L.8
  • 5
    • 77955983967 scopus 로고    scopus 로고
    • ANO1 amplification and expression in HNSCC with a high propensity for future distant metastasis and its functions in HNSCC cell lines
    • PID: 20664600
    • Ayoub C, Wasylyk C, Li Y, Thomas E, Marisa L, Robe A, Roux M, Abecassis J, de Reynies A, Wasylyk B (2010) ANO1 amplification and expression in HNSCC with a high propensity for future distant metastasis and its functions in HNSCC cell lines. Brit J Cancer 103:715–726
    • (2010) Brit J Cancer , vol.103 , pp. 715-726
    • Ayoub, C.1    Wasylyk, C.2    Li, Y.3    Thomas, E.4    Marisa, L.5    Robe, A.6    Roux, M.7    Abecassis, J.8    de Reynies, A.9    Wasylyk, B.10
  • 6
    • 0023481241 scopus 로고
    • Calcium-activated chloride current in cultured sensory and parasympathetic quail neurones
    • PID: 3502143
    • Bader CR, Bertrand D, Schlichter R (1987) Calcium-activated chloride current in cultured sensory and parasympathetic quail neurones. J Physiol 394:125–148
    • (1987) J Physiol , vol.394 , pp. 125-148
    • Bader, C.R.1    Bertrand, D.2    Schlichter, R.3
  • 7
    • 0033858348 scopus 로고    scopus 로고
    • Chloride secretion by the intestinal epithelium: molecular basis and regulatory aspects
    • Barrett KE, Keely SJ (2000) Chloride secretion by the intestinal epithelium: molecular basis and regulatory aspects. Ann Rev Physiol 62:535–572
    • (2000) Ann Rev Physiol , vol.62 , pp. 535-572
    • Barrett, K.E.1    Keely, S.J.2
  • 9
    • 84928739991 scopus 로고    scopus 로고
    • ANO1 interacts with EGFR and correlates with sensitivity to EGFR-targeting therapy in head and neck cancer
    • PID: 25823819
    • Bill A, Gutierrez A, Kulkarni S, Kemp C, Bonenfant D, Voshol H, Duvvuri U, Gaither LA (2015) ANO1 interacts with EGFR and correlates with sensitivity to EGFR-targeting therapy in head and neck cancer. Oncotarget 6:9173–9188
    • (2015) Oncotarget , vol.6 , pp. 9173-9188
    • Bill, A.1    Gutierrez, A.2    Kulkarni, S.3    Kemp, C.4    Bonenfant, D.5    Voshol, H.6    Duvvuri, U.7    Gaither, L.A.8
  • 14
    • 84918807150 scopus 로고    scopus 로고
    • X-ray structure of a calcium-activated TMEM16 lipid scramblase
    • PID: 25383531
    • Brunner JD, Lim NK, Schenck S, Duerst A, Dutzler R (2014) X-ray structure of a calcium-activated TMEM16 lipid scramblase. Nature 516:207–212
    • (2014) Nature , vol.516 , pp. 207-212
    • Brunner, J.D.1    Lim, N.K.2    Schenck, S.3    Duerst, A.4    Dutzler, R.5
  • 15
    • 84899750733 scopus 로고    scopus 로고
    • Anoctamin 1 induces calcium-activated chloride secretion and proliferation of renal cyst-forming epithelial cells
    • PID: 24152967
    • Buchholz B, Faria D, Schley G, Schreiber R, Eckardt KU, Kunzelmann K (2014) Anoctamin 1 induces calcium-activated chloride secretion and proliferation of renal cyst-forming epithelial cells. Kidney Int 85:1058–1067
    • (2014) Kidney Int , vol.85 , pp. 1058-1067
    • Buchholz, B.1    Faria, D.2    Schley, G.3    Schreiber, R.4    Eckardt, K.U.5    Kunzelmann, K.6
  • 23
    • 33845596849 scopus 로고    scopus 로고
    • Involvement of chloride channels in IGF-I-induced proliferation of porcine arterial smooth muscle cells
    • PID: 17126821
    • Cheng G, Kim MJ, Jia G, Agrawal DK (2007) Involvement of chloride channels in IGF-I-induced proliferation of porcine arterial smooth muscle cells. Cardiovasc Res 73:198–207
    • (2007) Cardiovasc Res , vol.73 , pp. 198-207
    • Cheng, G.1    Kim, M.J.2    Jia, G.3    Agrawal, D.K.4
  • 24
    • 84922772358 scopus 로고    scopus 로고
    • Anoctamin 1 mediates thermal pain as a heat sensor
    • PID: 24396339
    • Cho H, Oh U (2013) Anoctamin 1 mediates thermal pain as a heat sensor. Curr Neuropharmacol 11:641–651
    • (2013) Curr Neuropharmacol , vol.11 , pp. 641-651
    • Cho, H.1    Oh, U.2
  • 27
    • 0028983596 scopus 로고
    • Activation of Ca(2+)-dependent Cl- currents in cultured rat sensory neurones by flash photolysis of DM-nitrophen
    • PID: 7714823
    • Currie KP, Wootton JF, Scott RH (1995) Activation of Ca(2+)-dependent Cl- currents in cultured rat sensory neurones by flash photolysis of DM-nitrophen. J Physiol 482:291–307
    • (1995) J Physiol , vol.482 , pp. 291-307
    • Currie, K.P.1    Wootton, J.F.2    Scott, R.H.3
  • 30
    • 84947125358 scopus 로고    scopus 로고
    • TMEM16A/ANO1 is differentially expressed in HPV-negative versus HPV-positive head and neck squamous cell carcinoma through promoter methylation
    • PID: 26563938
    • Dixit R, Kemp C, Kulich S, Seethala R, Chiosea S, Ling S, Ha PK, Duvvuri U (2015) TMEM16A/ANO1 is differentially expressed in HPV-negative versus HPV-positive head and neck squamous cell carcinoma through promoter methylation. Sci Rep 5:16657
    • (2015) Sci Rep , vol.5 , pp. 16657
    • Dixit, R.1    Kemp, C.2    Kulich, S.3    Seethala, R.4    Chiosea, S.5    Ling, S.6    Ha, P.K.7    Duvvuri, U.8
  • 32
    • 84856292939 scopus 로고    scopus 로고
    • ANOs 3-7 in the anoctamin/Tmem16 Cl- channel family are intracellular proteins
    • PID: 22075693
    • Duran C, Qu Z, Osunkoya AO, Cui Y, Hartzell HC (2012) ANOs 3-7 in the anoctamin/Tmem16 Cl- channel family are intracellular proteins. Am J Physiol Cell Physiol 302:C482–C493
    • (2012) Am J Physiol Cell Physiol , vol.302 , pp. 482-493
    • Duran, C.1    Qu, Z.2    Osunkoya, A.O.3    Cui, Y.4    Hartzell, H.C.5
  • 35
    • 84923375293 scopus 로고    scopus 로고
    • A novel TMEM16A splice variant lacking the dimerization domain contributes to calcium-activated chloride secretion in human sweat gland epithelial cells
    • PID: 25220078
    • Ertongur-Fauth T, Hochheimer A, Buescher JM, Rapprich S, Krohn M (2014) A novel TMEM16A splice variant lacking the dimerization domain contributes to calcium-activated chloride secretion in human sweat gland epithelial cells. Exp Dermatol 23:825–831
    • (2014) Exp Dermatol , vol.23 , pp. 825-831
    • Ertongur-Fauth, T.1    Hochheimer, A.2    Buescher, J.M.3    Rapprich, S.4    Krohn, M.5
  • 41
    • 70349436013 scopus 로고    scopus 로고
    • Prognostic significance of epidermal growth factor receptor phosphorylation and mutation in head and neck squamous cell carcinoma
    • PID: 19726454
    • Hama T, Yuza Y, Saito Y, Ou J, Kondo S, Okabe M, Yamada H, Kato T, Moriyama H, Kurihara S, Urashima M (2009) Prognostic significance of epidermal growth factor receptor phosphorylation and mutation in head and neck squamous cell carcinoma. Oncologist 14:900–908
    • (2009) Oncologist , vol.14 , pp. 900-908
    • Hama, T.1    Yuza, Y.2    Saito, Y.3    Ou, J.4    Kondo, S.5    Okabe, M.6    Yamada, H.7    Kato, T.8    Moriyama, H.9    Kurihara, S.10    Urashima, M.11
  • 42
    • 0037143750 scopus 로고    scopus 로고
    • High-resolution mapping of the 11q13 amplicon and identification of a gene, TAOS1, that is amplified and overexpressed in oral cancer cells
    • PID: 12172009
    • Huang X, Gollin SM, Raja S, Godfrey TE (2002) High-resolution mapping of the 11q13 amplicon and identification of a gene, TAOS1, that is amplified and overexpressed in oral cancer cells. Proc Natl Acad Sci U S A 99:11369–11374
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 11369-11374
    • Huang, X.1    Gollin, S.M.2    Raja, S.3    Godfrey, T.E.4
  • 44
    • 84883313607 scopus 로고    scopus 로고
    • TMEM16C facilitates Na(+)-activated K+ currents in rat sensory neurons and regulates pain processing
    • PID: 23872594
    • Huang F, Wang X, Ostertag EM, Nuwal T, Huang B, Jan YN, Basbaum AI, Jan LY (2013) TMEM16C facilitates Na(+)-activated K+ currents in rat sensory neurons and regulates pain processing. Nat Neurosci 16:1284–1290
    • (2013) Nat Neurosci , vol.16 , pp. 1284-1290
    • Huang, F.1    Wang, X.2    Ostertag, E.M.3    Nuwal, T.4    Huang, B.5    Jan, Y.N.6    Basbaum, A.I.7    Jan, L.Y.8
  • 45
    • 84859645387 scopus 로고    scopus 로고
    • Calcium-activated chloride channels (CaCCs) regulate action potential and synaptic response in hippocampal neurons
    • PID: 22500639
    • Huang WC, Xiao S, Huang F, Harfe BD, Jan YN, Jan LY (2012) Calcium-activated chloride channels (CaCCs) regulate action potential and synaptic response in hippocampal neurons. Neuron 74:179–192
    • (2012) Neuron , vol.74 , pp. 179-192
    • Huang, W.C.1    Xiao, S.2    Huang, F.3    Harfe, B.D.4    Jan, Y.N.5    Jan, L.Y.6
  • 48
    • 79954450960 scopus 로고    scopus 로고
    • DOG1 antibody is a highly sensitive and specific marker for gastrointestinal stromal tumors in cytology cell blocks
    • PID: 21350101
    • Hwang DG, Qian X, Hornick JL (2011) DOG1 antibody is a highly sensitive and specific marker for gastrointestinal stromal tumors in cytology cell blocks. Am J Clin Pathol 135:448–453
    • (2011) Am J Clin Pathol , vol.135 , pp. 448-453
    • Hwang, D.G.1    Qian, X.2    Hornick, J.L.3
  • 49
    • 84902356090 scopus 로고    scopus 로고
    • Anoctamin 1 in secretory epithelia
    • Jang Y, and Oh U (2014) Anoctamin 1 in secretory epithelia. Cell Calcium
    • (2014) Cell Calcium
    • Jang, Y.1    Oh, U.2
  • 50
    • 84942940994 scopus 로고    scopus 로고
    • Inhibition of calcium-activated chloride channel ANO1/TMEM16A suppresses tumor growth and invasion in human lung cancer
    • PID: 26305547
    • Jia L, Liu W, Guan L, Lu M, Wang K (2015) Inhibition of calcium-activated chloride channel ANO1/TMEM16A suppresses tumor growth and invasion in human lung cancer. PLoS One 10:e0136584
    • (2015) PLoS One , vol.10 , pp. 136584
    • Jia, L.1    Liu, W.2    Guan, L.3    Lu, M.4    Wang, K.5
  • 52
    • 0042628162 scopus 로고    scopus 로고
    • FLJ10261 gene, located within the CCND1-EMS1 locus on human chromosome 11q13, encodes the eight-transmembrane protein homologous to C12orf3, C11orf25 and FLJ34272 gene products
    • PID: 12739008
    • Katoh M, Katoh M (2003) FLJ10261 gene, located within the CCND1-EMS1 locus on human chromosome 11q13, encodes the eight-transmembrane protein homologous to C12orf3, C11orf25 and FLJ34272 gene products. Int J Oncol 22:1375–1381
    • (2003) Int J Oncol , vol.22 , pp. 1375-1381
    • Katoh, M.1    Katoh, M.2
  • 53
    • 0030790180 scopus 로고    scopus 로고
    • High-gain, low-noise amplification in olfactory transduction
    • PID: 9251827
    • Kleene SJ (1997) High-gain, low-noise amplification in olfactory transduction. Biophys J 73:1110–1117
    • (1997) Biophys J , vol.73 , pp. 1110-1117
    • Kleene, S.J.1
  • 54
    • 0025719977 scopus 로고
    • Calcium-activated chloride conductance in frog olfactory cilia
    • PID: 1941099
    • Kleene SJ, Gesteland RC (1991) Calcium-activated chloride conductance in frog olfactory cilia. J Neurosci 11:3624–3629
    • (1991) J Neurosci , vol.11 , pp. 3624-3629
    • Kleene, S.J.1    Gesteland, R.C.2
  • 55
    • 0027274828 scopus 로고
    • Intracellular calcium ions activate a low-conductance chloride channel in smooth-muscle cells isolated from human mesenteric artery
    • PID: 8414911
    • Klockner U (1993) Intracellular calcium ions activate a low-conductance chloride channel in smooth-muscle cells isolated from human mesenteric artery. Pflugers Arch 424:231–237
    • (1993) Pflugers Arch , vol.424 , pp. 231-237
    • Klockner, U.1
  • 57
    • 0032894279 scopus 로고    scopus 로고
    • Dynamics of calcium regulation of chloride currents in Xenopus oocytes
    • PID: 9886932
    • Kuruma A, Hartzell HC (1999) Dynamics of calcium regulation of chloride currents in Xenopus oocytes. Am J Physiol 276:C161–C175
    • (1999) Am J Physiol , vol.276 , pp. 161-175
    • Kuruma, A.1    Hartzell, H.C.2
  • 58
    • 0033971365 scopus 로고    scopus 로고
    • Bimodal control of a Ca(2+)-activated Cl(-) channel by different Ca(2+) signals
    • PID: 10613919
    • Kuruma A, Hartzell HC (2000) Bimodal control of a Ca(2+)-activated Cl(-) channel by different Ca(2+) signals. J Gen Physiol 115:59–80
    • (2000) J Gen Physiol , vol.115 , pp. 59-80
    • Kuruma, A.1    Hartzell, H.C.2
  • 59
    • 0028074814 scopus 로고
    • Calcium-activated chloride current in rabbit coronary artery myocytes
    • PID: 7923619
    • Lamb FS, Volk KA, Shibata EF (1994) Calcium-activated chloride current in rabbit coronary artery myocytes. Circ Res 75:742–750
    • (1994) Circ Res , vol.75 , pp. 742-750
    • Lamb, F.S.1    Volk, K.A.2    Shibata, E.F.3
  • 60
    • 0029757293 scopus 로고    scopus 로고
    • Characteristics and physiological role of the Ca(2+)-activated Cl- conductance in smooth muscle
    • PID: 8769982
    • Large WA, Wang Q (1996) Characteristics and physiological role of the Ca(2+)-activated Cl- conductance in smooth muscle. Am J Physiol 271:C435–C454
    • (1996) Am J Physiol , vol.271 , pp. 435-454
    • Large, W.A.1    Wang, Q.2
  • 61
    • 84892763451 scopus 로고    scopus 로고
    • Anoctamin 1 contributes to inflammatory and nerve-injury induced hypersensitivity
    • PID: 24450308
    • Lee B, Cho H, Jung J, Yang YD, Yang DJ, Oh U (2014) Anoctamin 1 contributes to inflammatory and nerve-injury induced hypersensitivity. Mol Pain 10:5
    • (2014) Mol Pain , vol.10 , pp. 5
    • Lee, B.1    Cho, H.2    Jung, J.3    Yang, Y.D.4    Yang, D.J.5    Oh, U.6
  • 62
    • 77951748211 scopus 로고    scopus 로고
    • The utility of discovered on gastrointestinal stromal tumor 1 (DOG1) antibody in surgical pathology-the GIST of it
    • PID: 20418677
    • Lee CH, Liang CW, Espinosa I (2010) The utility of discovered on gastrointestinal stromal tumor 1 (DOG1) antibody in surgical pathology-the GIST of it. Adv Anat Pathol 17:222–232
    • (2010) Adv Anat Pathol , vol.17 , pp. 222-232
    • Lee, C.H.1    Liang, C.W.2    Espinosa, I.3
  • 63
    • 84903954768 scopus 로고    scopus 로고
    • ANO1 as a marker of oral squamous cell carcinoma and silencing ANO1 suppresses migration of human SCC-25 cells
    • Li Y, Zhang J, Hong S (2014) ANO1 as a marker of oral squamous cell carcinoma and silencing ANO1 suppresses migration of human SCC-25 cells. Med Oral, Pathol Oral Cir Bucal 19:e313–e319
    • (2014) Med Oral, Pathol Oral Cir Bucal , vol.19 , pp. 313-319
    • Li, Y.1    Zhang, J.2    Hong, S.3
  • 64
    • 77951183327 scopus 로고    scopus 로고
    • The acute nociceptive signals induced by bradykinin in rat sensory neurons are mediated by inhibition of M-type K+ channels and activation of Ca2+-activated Cl- channels
    • PID: 20335661
    • Liu B, Linley JE, Du X, Zhang X, Ooi L, Zhang H, Gamper N (2010) The acute nociceptive signals induced by bradykinin in rat sensory neurons are mediated by inhibition of M-type K+ channels and activation of Ca2+-activated Cl- channels. J Clin Invest 120:1240–1252
    • (2010) J Clin Invest , vol.120 , pp. 1240-1252
    • Liu, B.1    Linley, J.E.2    Du, X.3    Zhang, X.4    Ooi, L.5    Zhang, H.6    Gamper, N.7
  • 65
    • 84893848153 scopus 로고    scopus 로고
    • Transmembrane protein with unknown function 16A overexpression promotes glioma formation through the nuclear factor-kappaB signaling pathway
    • PID: 24401903
    • Liu J, Liu Y, Ren Y, Kang L, Zhang L (2014) Transmembrane protein with unknown function 16A overexpression promotes glioma formation through the nuclear factor-kappaB signaling pathway. Mol Med Rep 9:1068–1074
    • (2014) Mol Med Rep , vol.9 , pp. 1068-1074
    • Liu, J.1    Liu, Y.2    Ren, Y.3    Kang, L.4    Zhang, L.5
  • 66
    • 84866143707 scopus 로고    scopus 로고
    • Inhibition of Ca(2+)-activated Cl(-) channel ANO1/TMEM16A expression suppresses tumor growth and invasiveness in human prostate carcinoma
    • PID: 22820160
    • Liu W, Lu M, Liu B, Huang Y, Wang K (2012) Inhibition of Ca(2+)-activated Cl(-) channel ANO1/TMEM16A expression suppresses tumor growth and invasiveness in human prostate carcinoma. Cancer Lett 326:41–51
    • (2012) Cancer Lett , vol.326 , pp. 41-51
    • Liu, W.1    Lu, M.2    Liu, B.3    Huang, Y.4    Wang, K.5
  • 67
    • 77954517197 scopus 로고    scopus 로고
    • TMEM16A/anoctamin 1 protein mediates calcium-activated chloride currents in pulmonary arterial smooth muscle cells
    • PID: 20421283
    • Manoury B, Tamuleviciute A, Tammaro P (2010) TMEM16A/anoctamin 1 protein mediates calcium-activated chloride currents in pulmonary arterial smooth muscle cells. J Physiol 588:2305–2314
    • (2010) J Physiol , vol.588 , pp. 2305-2314
    • Manoury, B.1    Tamuleviciute, A.2    Tammaro, P.3
  • 70
    • 0012171447 scopus 로고    scopus 로고
    • Ca2+-activated Cl- current in salivary and lacrimal glands
    • Fuller CM, (ed), Academic, New York
    • Melvin JE, Arreola J, Nehrke K, Begenisich T (2002) Ca2+-activated Cl- current in salivary and lacrimal glands. In: Fuller CM (ed) Calcium-activated chloride channels. Academic, New York, pp 209–230
    • (2002) Calcium-activated chloride channels , pp. 209-230
    • Melvin, J.E.1    Arreola, J.2    Nehrke, K.3    Begenisich, T.4
  • 71
    • 70249090434 scopus 로고    scopus 로고
    • DOG1 antibody in the differential diagnosis of gastrointestinal stromal tumors: a study of 1840 cases
    • PID: 19606013
    • Miettinen M, Wang ZF, Lasota J (2009) DOG1 antibody in the differential diagnosis of gastrointestinal stromal tumors: a study of 1840 cases. Am J Surg Pathol 33:1401–1408
    • (2009) Am J Surg Pathol , vol.33 , pp. 1401-1408
    • Miettinen, M.1    Wang, Z.F.2    Lasota, J.3
  • 73
    • 84859710006 scopus 로고    scopus 로고
    • Epidermal growth factor chronically upregulates Ca(2+)-dependent Cl(-) conductance and TMEM16A expression in intestinal epithelial cells
    • PID: 22351639
    • Mroz MS, Keely SJ (2012) Epidermal growth factor chronically upregulates Ca(2+)-dependent Cl(-) conductance and TMEM16A expression in intestinal epithelial cells. J Physiol 590:1907–1920
    • (2012) J Physiol , vol.590 , pp. 1907-1920
    • Mroz, M.S.1    Keely, S.J.2
  • 74
    • 78751478642 scopus 로고    scopus 로고
    • TMEM16A inhibitors reveal TMEM16A as a minor component of calcium-activated chloride channel conductance in airway and intestinal epithelial cells
    • PID: 21084298
    • Namkung W, Phuan PW, Verkman AS (2011) TMEM16A inhibitors reveal TMEM16A as a minor component of calcium-activated chloride channel conductance in airway and intestinal epithelial cells. J Biol Chem 286:2365–2374
    • (2011) J Biol Chem , vol.286 , pp. 2365-2374
    • Namkung, W.1    Phuan, P.W.2    Verkman, A.S.3
  • 75
    • 0034789020 scopus 로고    scopus 로고
    • Ion channels and their functional role in vascular endothelium
    • PID: 11581493
    • Nilius B, Droogmans G (2001) Ion channels and their functional role in vascular endothelium. Physiol Rev 81:1415–1459
    • (2001) Physiol Rev , vol.81 , pp. 1415-1459
    • Nilius, B.1    Droogmans, G.2
  • 76
    • 0031015379 scopus 로고    scopus 로고
    • Calcium-activated chloride channels in bovine pulmonary artery endothelial cells
    • PID: 9032686
    • Nilius B, Prenen J, Szucs G, Wei L, Tanzi F, Voets T, Droogmans G (1997) Calcium-activated chloride channels in bovine pulmonary artery endothelial cells. J Physiol 498:381–396
    • (1997) J Physiol , vol.498 , pp. 381-396
    • Nilius, B.1    Prenen, J.2    Szucs, G.3    Wei, L.4    Tanzi, F.5    Voets, T.6    Droogmans, G.7
  • 78
  • 79
    • 84881163924 scopus 로고    scopus 로고
    • Epidermal growth factor-induced cellular invasion requires sphingosine-1-phosphate/sphingosine-1-phosphate 2 receptor-mediated ezrin activation
    • PID: 23629860
    • Orr Gandy KA, Adada M, Canals D, Carroll B, Roddy P, Hannun YA, Obeid LM (2013) Epidermal growth factor-induced cellular invasion requires sphingosine-1-phosphate/sphingosine-1-phosphate 2 receptor-mediated ezrin activation. FASEB J 27:3155–3166
    • (2013) FASEB J , vol.27 , pp. 3155-3166
    • Orr Gandy, K.A.1    Adada, M.2    Canals, D.3    Carroll, B.4    Roddy, P.5    Hannun, Y.A.6    Obeid, L.M.7
  • 81
    • 79955642356 scopus 로고    scopus 로고
    • Rotavirus toxin NSP4 induces diarrhea by activation of TMEM16A and inhibition of Na+ absorption
    • PID: 21399895
    • Ousingsawat J, Mirza M, Tian Y, Roussa E, Schreiber R, Cook DI, Kunzelmann K (2011) Rotavirus toxin NSP4 induces diarrhea by activation of TMEM16A and inhibition of Na+ absorption. Pflugers Arch 461:579–589
    • (2011) Pflugers Arch , vol.461 , pp. 579-589
    • Ousingsawat, J.1    Mirza, M.2    Tian, Y.3    Roussa, E.4    Schreiber, R.5    Cook, D.I.6    Kunzelmann, K.7
  • 82
    • 0026641697 scopus 로고
    • Calcium-dependence of the calcium-activated chloride current in smooth muscle cells of rat portal vein
    • PID: 1382263
    • Pacaud P, Loirand G, Gregoire G, Mironneau C, Mironneau J (1992) Calcium-dependence of the calcium-activated chloride current in smooth muscle cells of rat portal vein. Pflugers Arch 421:125–130
    • (1992) Pflugers Arch , vol.421 , pp. 125-130
    • Pacaud, P.1    Loirand, G.2    Gregoire, G.3    Mironneau, C.4    Mironneau, J.5
  • 83
    • 0033779852 scopus 로고    scopus 로고
    • Development of intestinal transport function in mammals
    • PID: 11015621
    • Pacha J (2000) Development of intestinal transport function in mammals. Physiol Rev 80:1633–1667
    • (2000) Physiol Rev , vol.80 , pp. 1633-1667
    • Pacha, J.1
  • 84
    • 84862980716 scopus 로고    scopus 로고
    • Anoctamin 1 (Tmem16A) Ca2+-activated chloride channel stoichiometrically interacts with an ezrin-radixin-moesin network
    • PID: 22685202
    • Perez-Cornejo P, Gokhale A, Duran C, Cui Y, Xiao Q, Hartzell HC, Faundez V (2012) Anoctamin 1 (Tmem16A) Ca2+-activated chloride channel stoichiometrically interacts with an ezrin-radixin-moesin network. Proc Natl Acad Sci U S A 109:10376–10381
    • (2012) Proc Natl Acad Sci U S A , vol.109 , pp. 10376-10381
    • Perez-Cornejo, P.1    Gokhale, A.2    Duran, C.3    Cui, Y.4    Xiao, Q.5    Hartzell, H.C.6    Faundez, V.7
  • 85
    • 84925321705 scopus 로고    scopus 로고
    • Four basic residues critical for the ion selectivity and pore blocker sensitivity of TMEM16A calcium-activated chloride channels
    • PID: 25733897
    • Peters CJ, Yu H, Tien J, Jan YN, Li M, Jan LY (2015) Four basic residues critical for the ion selectivity and pore blocker sensitivity of TMEM16A calcium-activated chloride channels. Proc Natl Acad Sci U S A 112:3547–3552
    • (2015) Proc Natl Acad Sci U S A , vol.112 , pp. 3547-3552
    • Peters, C.J.1    Yu, H.2    Tien, J.3    Jan, Y.N.4    Li, M.5    Jan, L.Y.6
  • 86
    • 70349573000 scopus 로고    scopus 로고
    • TMEM16B induces chloride currents activated by calcium in mammalian cells
    • PID: 19475416
    • Pifferi S, Dibattista M, Menini A (2009) TMEM16B induces chloride currents activated by calcium in mammalian cells. Pflugers Arch 458:1023–1038
    • (2009) Pflugers Arch , vol.458 , pp. 1023-1038
    • Pifferi, S.1    Dibattista, M.2    Menini, A.3
  • 90
    • 84871928656 scopus 로고    scopus 로고
    • DOG1 immunoreactivity in uterine leiomyosarcomas
    • PID: 23038686
    • Sah SP, McCluggage WG (2013) DOG1 immunoreactivity in uterine leiomyosarcomas. J Clin Pathol 66:40–43
    • (2013) J Clin Pathol , vol.66 , pp. 40-43
    • Sah, S.P.1    McCluggage, W.G.2
  • 93
    • 84939891077 scopus 로고    scopus 로고
    • Anoctamins support calcium-dependent chloride secretion by facilitating calcium signaling in adult mouse intestine
    • PID: 24974903
    • Schreiber R, Faria D, Skryabin BV, Wanitchakool P, Rock JR, Kunzelmann K (2015) Anoctamins support calcium-dependent chloride secretion by facilitating calcium signaling in adult mouse intestine. Pflugers Arch 467:1203–1213
    • (2015) Pflugers Arch , vol.467 , pp. 1203-1213
    • Schreiber, R.1    Faria, D.2    Skryabin, B.V.3    Wanitchakool, P.4    Rock, J.R.5    Kunzelmann, K.6
  • 94
    • 51549120559 scopus 로고    scopus 로고
    • Expression cloning of TMEM16A as a calcium-activated chloride channel subunit
    • PID: 18805094
    • Schroeder BC, Cheng T, Jan YN, Jan LY (2008) Expression cloning of TMEM16A as a calcium-activated chloride channel subunit. Cell 134:1019–1029
    • (2008) Cell , vol.134 , pp. 1019-1029
    • Schroeder, B.C.1    Cheng, T.2    Jan, Y.N.3    Jan, L.Y.4
  • 95
    • 0023942104 scopus 로고
    • Modulation of divalent cation-activated chloride ion currents
    • Scott RH, McGuirk SM, Dolphin AC (1988) Modulation of divalent cation-activated chloride ion currents. Brit J Pharmacol 94:653–662
    • (1988) Brit J Pharmacol , vol.94 , pp. 653-662
    • Scott, R.H.1    McGuirk, S.M.2    Dolphin, A.C.3
  • 97
    • 84887127381 scopus 로고    scopus 로고
    • Consistent and differential genetic aberrations between esophageal dysplasia and squamous cell carcinoma detected by array comparative genomic hybridization
    • PID: 24009147
    • Shi ZZ, Shang L, Jiang YY, Hao JJ, Zhang Y, Zhang TT, Lin DC, Liu SG, Wang BS, Gong T, Zhan QM, Wang MR (2013) Consistent and differential genetic aberrations between esophageal dysplasia and squamous cell carcinoma detected by array comparative genomic hybridization. Clin Cancer Res 19:5867–5878
    • (2013) Clin Cancer Res , vol.19 , pp. 5867-5878
    • Shi, Z.Z.1    Shang, L.2    Jiang, Y.Y.3    Hao, J.J.4    Zhang, Y.5    Zhang, T.T.6    Lin, D.C.7    Liu, S.G.8    Wang, B.S.9    Gong, T.10    Zhan, Q.M.11    Wang, M.R.12
  • 98
    • 0028297830 scopus 로고
    • Effects of metabolic blockers on Ca(2+)-dependent currents in cultured sensory neurones from neonatal rats
    • PID: 8012725
    • Stapleton SR, Scott RH, Bell BA (1994) Effects of metabolic blockers on Ca(2+)-dependent currents in cultured sensory neurones from neonatal rats. Br J Pharmacol 111:57–64
    • (1994) Br J Pharmacol , vol.111 , pp. 57-64
    • Stapleton, S.R.1    Scott, R.H.2    Bell, B.A.3
  • 99
    • 67650866710 scopus 로고    scopus 로고
    • ANO2 is the cilial calcium-activated chloride channel that may mediate olfactory amplification
    • PID: 19561302
    • Stephan AB, Shum EY, Hirsh S, Cygnar KD, Reisert J, Zhao H (2009) ANO2 is the cilial calcium-activated chloride channel that may mediate olfactory amplification. Proc Natl Acad Sci U S A 106:11776–11781
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 11776-11781
    • Stephan, A.B.1    Shum, E.Y.2    Hirsh, S.3    Cygnar, K.D.4    Reisert, J.5    Zhao, H.6
  • 100
    • 84919924478 scopus 로고    scopus 로고
    • Inhibition of TMEM16A expression suppresses growth and invasion in human colorectal cancer cells
    • PID: 25541940
    • Sui Y, Sun M, Wu F, Yang L, Di W, Zhang G, Zhong L, Ma Z, Zheng J, Fang X, Ma T (2014) Inhibition of TMEM16A expression suppresses growth and invasion in human colorectal cancer cells. PLoS One 9:e115443
    • (2014) PLoS One , vol.9 , pp. 115443
    • Sui, Y.1    Sun, M.2    Wu, F.3    Yang, L.4    Di, W.5    Zhang, G.6    Zhong, L.7    Ma, Z.8    Zheng, J.9    Fang, X.10    Ma, T.11
  • 101
    • 84864297897 scopus 로고    scopus 로고
    • Chronic hypoxia-induced upregulation of Ca2+-activated Cl- channel in pulmonary arterial myocytes: a mechanism contributing to enhanced vasoreactivity
    • PID: 22674716
    • Sun H, Xia Y, Paudel O, Yang XR, Sham JS (2012) Chronic hypoxia-induced upregulation of Ca2+-activated Cl- channel in pulmonary arterial myocytes: a mechanism contributing to enhanced vasoreactivity. J Physiol 590:3507–3521
    • (2012) J Physiol , vol.590 , pp. 3507-3521
    • Sun, H.1    Xia, Y.2    Paudel, O.3    Yang, X.R.4    Sham, J.S.5
  • 102
    • 84877709762 scopus 로고    scopus 로고
    • Calcium-dependent phospholipid scramblase activity of TMEM16 protein family members
    • PID: 23532839
    • Suzuki J, Fujii T, Imao T, Ishihara K, Kuba H, Nagata S (2013) Calcium-dependent phospholipid scramblase activity of TMEM16 protein family members. J Biol Chem 288:13305–13316
    • (2013) J Biol Chem , vol.288 , pp. 13305-13316
    • Suzuki, J.1    Fujii, T.2    Imao, T.3    Ishihara, K.4    Kuba, H.5    Nagata, S.6
  • 103
    • 78650172970 scopus 로고    scopus 로고
    • Calcium-dependent phospholipid scrambling by TMEM16F
    • PID: 21107324
    • Suzuki J, Umeda M, Sims PJ, Nagata S (2010) Calcium-dependent phospholipid scrambling by TMEM16F. Nature 468:834–838
    • (2010) Nature , vol.468 , pp. 834-838
    • Suzuki, J.1    Umeda, M.2    Sims, P.J.3    Nagata, S.4
  • 104
    • 84928308934 scopus 로고    scopus 로고
    • Pain-enhancing mechanism through interaction between TRPV1 and anoctamin 1 in sensory neurons
    • PID: 25848051
    • Takayama Y, Uta D, Furue H, Tominaga M (2015) Pain-enhancing mechanism through interaction between TRPV1 and anoctamin 1 in sensory neurons. Proc Natl Acad Sci U S A 112:5213–5218
    • (2015) Proc Natl Acad Sci U S A , vol.112 , pp. 5213-5218
    • Takayama, Y.1    Uta, D.2    Furue, H.3    Tominaga, M.4
  • 106
    • 84905186544 scopus 로고    scopus 로고
    • A comprehensive search for calcium binding sites critical for TMEM16A calcium-activated chloride channel activity
    • Tien J, Peters CJ, Wong XM, Cheng T, Jan YN, Jan LY, and Yang H (2014) A comprehensive search for calcium binding sites critical for TMEM16A calcium-activated chloride channel activity. Elife e02772
    • (2014) Elife , vol.e02772
    • Tien, J.1    Peters, C.J.2    Wong, X.M.3    Cheng, T.4    Jan, Y.N.5    Jan, L.Y.6    Yang, H.7
  • 109
    • 0031043523 scopus 로고    scopus 로고
    • ERM (ezrin/radixin/moesin) family: from cytoskeleton to signal transduction
    • PID: 9013673
    • Tsukita S, Yonemura S (1997) ERM (ezrin/radixin/moesin) family: from cytoskeleton to signal transduction. Curr Opin Cell Biol 9:70–75
    • (1997) Curr Opin Cell Biol , vol.9 , pp. 70-75
    • Tsukita, S.1    Yonemura, S.2
  • 110
    • 70350509805 scopus 로고    scopus 로고
    • Intestinal mucosal barrier function in health and disease
    • PID: 19855405
    • Turner JR (2009) Intestinal mucosal barrier function in health and disease. Nature Rev Immun 9:799–809
    • (2009) Nature Rev Immun , vol.9 , pp. 799-809
    • Turner, J.R.1
  • 112
    • 84930657584 scopus 로고    scopus 로고
    • Ano1/TMEM16A overexpression is associated with good prognosis in PR-positive or HER2-negative breast cancer patients following tamoxifen treatment
    • PID: 25961581
    • Wu H, Guan S, Sun M, Yu Z, Zhao L, He M, Zhao H, Yao W, Wang E, Jin F, Xiao Q, Wei M (2015) Ano1/TMEM16A overexpression is associated with good prognosis in PR-positive or HER2-negative breast cancer patients following tamoxifen treatment. PLoS One 10:e0126128
    • (2015) PLoS One , vol.10 , pp. 126128
    • Wu, H.1    Guan, S.2    Sun, M.3    Yu, Z.4    Zhao, L.5    He, M.6    Zhao, H.7    Yao, W.8    Wang, E.9    Jin, F.10    Xiao, Q.11    Wei, M.12
  • 113
    • 0037192511 scopus 로고    scopus 로고
    • Effects of Cl- channel blockers on endothelin-1-induced proliferation of rat vascular smooth muscle cells
    • PID: 12005183
    • Xiao GN, Guan YY, He H (2002) Effects of Cl- channel blockers on endothelin-1-induced proliferation of rat vascular smooth muscle cells. Life Sci 70:2233–2241
    • (2002) Life Sci , vol.70 , pp. 2233-2241
    • Xiao, G.N.1    Guan, Y.Y.2    He, H.3
  • 114
    • 79957786620 scopus 로고    scopus 로고
    • Voltage- and calcium-dependent gating of TMEM16A/Ano1 chloride channels are physically coupled by the first intracellular loop
    • PID: 21555582
    • Xiao Q, Yu K, Perez-Cornejo P, Cui Y, Arreola J, Hartzell HC (2011) Voltage- and calcium-dependent gating of TMEM16A/Ano1 chloride channels are physically coupled by the first intracellular loop. Proc Natl Acad Sci U S A 108:8891–8896
    • (2011) Proc Natl Acad Sci U S A , vol.108 , pp. 8891-8896
    • Xiao, Q.1    Yu, K.2    Perez-Cornejo, P.3    Cui, Y.4    Arreola, J.5    Hartzell, H.C.6
  • 115
    • 84912535339 scopus 로고    scopus 로고
    • Mapping of long-range INS promoter interactions reveals a role for calcium-activated chloride channel ANO1 in insulin secretion
    • PID: 25385647
    • Xu Z, Lefevre GM, Gavrilova O, Foster St Claire MB, Riddick G, Felsenfeld G (2014) Mapping of long-range INS promoter interactions reveals a role for calcium-activated chloride channel ANO1 in insulin secretion. Proc Natl Acad Sci U S A 111:16760–16765
    • (2014) Proc Natl Acad Sci U S A , vol.111 , pp. 16760-16765
    • Xu, Z.1    Lefevre, G.M.2    Gavrilova, O.3    Foster St Claire, M.B.4    Riddick, G.5    Felsenfeld, G.6
  • 117
    • 84871860558 scopus 로고    scopus 로고
    • TMEM16F forms a Ca2+-activated cation channel required for lipid scrambling in platelets during blood coagulation
    • PID: 23021219
    • Yang H, Kim A, David T, Palmer D, Jin T, Tien J, Huang F, Cheng T, Coughlin SR, Jan YN, Jan LY (2012) TMEM16F forms a Ca2+-activated cation channel required for lipid scrambling in platelets during blood coagulation. Cell 151:111–122
    • (2012) Cell , vol.151 , pp. 111-122
    • Yang, H.1    Kim, A.2    David, T.3    Palmer, D.4    Jin, T.5    Tien, J.6    Huang, F.7    Cheng, T.8    Coughlin, S.R.9    Jan, Y.N.10    Jan, L.Y.11
  • 118
    • 84859435658 scopus 로고    scopus 로고
    • Explaining calcium-dependent gating of anoctamin-1 chloride channels requires a revised topology
    • PID: 22394518
    • Yu K, Duran C, Qu Z, Cui YY, Hartzell HC (2012) Explaining calcium-dependent gating of anoctamin-1 chloride channels requires a revised topology. Circ Res 110:990–999
    • (2012) Circ Res , vol.110 , pp. 990-999
    • Yu, K.1    Duran, C.2    Qu, Z.3    Cui, Y.Y.4    Hartzell, H.C.5
  • 120
    • 0028004272 scopus 로고
    • Intracellular calcium activates a chloride current in canine ventricular myocytes
    • PID: 7977830
    • Zygmunt AC (1994) Intracellular calcium activates a chloride current in canine ventricular myocytes. Am J Physiol 267:H1984–H1995
    • (1994) Am J Physiol , vol.267 , pp. 1984-1995
    • Zygmunt, A.C.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.