Small molecule-facilitated degradation of ANO1 protein: A new targeting approach for anticancer therapeutics

Journal of Biological Chemistry

Volumn 289, Issue 16, 2014, Pages 11029-11041

  Bill, Anke ^a   Hall, Michelle Lynn ^a,c   Borawski, Jason ^a   Hodgson, Catherine ^a   Jenkins, Jeremy ^a   Piechon, Philippe ^b   Popa, Oana ^a   Rothwell, Christopher ^a   Tranter, Pamela ^a   Tria, Scott ^a   Wagner, Trixie ^b   Whitehead, Lewis ^a   Gaither, L Alex ^a  

^a NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH   (United States)

^b NOVARTIS PHARMA AG   (Switzerland)

^c SCHRÖDINGER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL PROLIFERATION; CELLS; CHLORINE COMPOUNDS; DISEASES;

ANTI-CANCER THERAPEUTICS; ANTI-TUMORS; CHLORIDE CHANNELS; NOVEL FUNCTIONS;

PROTEINS;

ANTINEOPLASTIC AGENT; CALCIUM ACTIVATED CHLORIDE CHANNEL; CALCIUM ACTIVATED CHLORIDE CHANNEL INHIBITOR A01; CHLORIDE CHANNEL BLOCKING AGENT; PROTEIN ANO1; UNCLASSIFIED DRUG;

ANTIPROLIFERATIVE ACTIVITY; ARTICLE; CANCER CELL; CELL PROLIFERATION; CHANNEL GATING; COMPUTER MODEL; CONTROLLED STUDY; DRUG TARGETING; ENDOPLASMIC RETICULUM; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN FUNCTION; STRUCTURE ACTIVITY RELATION;

ANTICANCER DRUG; CANCER BIOLOGY; CANCER THERAPY; CHLORIDE CHANNELS; COMPUTATIONAL BIOLOGY; ER-ASSOCIATED DEGRADATION; ION CHANNELS; MOLECULAR MODELING; PROTEIN DEGRADATION; SMALL MOLECULES;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL PROLIFERATION; CHLORIDE CHANNELS; DRUG DELIVERY SYSTEMS; HUMANS; NEOPLASM PROTEINS; NEOPLASMS; PROTEOLYSIS;

EID: 84899014111     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.549188     Document Type: Article

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