메뉴 건너뛰기




Volumn 110, Issue 11, 2013, Pages

Calcium-activated chloride channel ANO1 promotes breast cancer progression by activating EGFR and CAMK signaling

Author keywords

CaCCinh A01; ESCC; HNSCC; Ion channel; TMEM16A

Indexed keywords

ANOCTAMIN 1; CALCIUM ACTIVATED CHLORIDE CHANNEL; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE II; EPIDERMAL GROWTH FACTOR RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN KINASE B; UNCLASSIFIED DRUG;

EID: 84875035786     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1217072110     Document Type: Article
Times cited : (265)

References (59)
  • 1
    • 10944228766 scopus 로고    scopus 로고
    • Oncogene addiction: Sometimes a temporary slavery
    • Jonkers J, Berns A (2004) Oncogene addiction: Sometimes a temporary slavery. Cancer Cell 6(6):535-538.
    • (2004) Cancer Cell , vol.6 , Issue.6 , pp. 535-538
    • Jonkers, J.1    Berns, A.2
  • 3
    • 3042594995 scopus 로고    scopus 로고
    • The novel marker, DOG1, is expressed ubiquitously in gastrointestinal stromal tumors irrespective of KIT or PDGFRA mutation status
    • West RB, et al. (2004) The novel marker, DOG1, is expressed ubiquitously in gastrointestinal stromal tumors irrespective of KIT or PDGFRA mutation status. Am J Pathol 165(1):107-113.
    • (2004) Am J Pathol , vol.165 , Issue.1 , pp. 107-113
    • West, R.B.1
  • 4
    • 66149134040 scopus 로고    scopus 로고
    • Genomewide mRNA profiling of esophageal squamous cell carcinoma for identification of cancer biomarkers
    • Kashyap MK, et al. (2009) Genomewide mRNA profiling of esophageal squamous cell carcinoma for identification of cancer biomarkers. Cancer Biol Ther 8(1):36-46.
    • (2009) Cancer Biol Ther , vol.8 , Issue.1 , pp. 36-46
    • Kashyap, M.K.1
  • 5
    • 33645026574 scopus 로고    scopus 로고
    • Head and neck squamous cell carcinoma transcriptome analysis by comprehensive validated differential display
    • Carles A, et al. (2006) Head and neck squamous cell carcinoma transcriptome analysis by comprehensive validated differential display. Oncogene 25(12):1821-1831.
    • (2006) Oncogene , vol.25 , Issue.12 , pp. 1821-1831
    • Carles, A.1
  • 7
    • 78149477701 scopus 로고    scopus 로고
    • Genomic subtypes of breast cancer identified by arraycomparative genomic hybridization display distinct molecular and clinical characteristics
    • Jönsson G, et al. (2010) Genomic subtypes of breast cancer identified by arraycomparative genomic hybridization display distinct molecular and clinical characteristics. Breast Cancer Res 12(3):R42.
    • (2010) Breast Cancer Res , vol.12 , Issue.3
    • Jönsson, G.1
  • 8
    • 62849094790 scopus 로고    scopus 로고
    • Distinctive clinicopathological associations of amplification of the cortactin gene at 11q13 in head and neck squamous cell carcinomas
    • Rodrigo JP, et al. (2009) Distinctive clinicopathological associations of amplification of the cortactin gene at 11q13 in head and neck squamous cell carcinomas. J Pathol 217 (4):516-523.
    • (2009) J Pathol , vol.217 , Issue.4 , pp. 516-523
    • Rodrigo, J.P.1
  • 9
    • 79952497178 scopus 로고    scopus 로고
    • Identification of a therapeutic strategy targeting amplified FGF19 in liver cancer by Oncogenomic screening
    • Sawey ET, et al. (2011) Identification of a therapeutic strategy targeting amplified FGF19 in liver cancer by Oncogenomic screening. Cancer Cell 19(3):347-358.
    • (2011) Cancer Cell , vol.19 , Issue.3 , pp. 347-358
    • Sawey, E.T.1
  • 10
    • 0029043876 scopus 로고
    • The involvement of the chromosome 11q13 region in human malignancies: Cyclin D1 and EMS1 are two new candidate oncogenes - A review
    • Schuuring E (1995) The involvement of the chromosome 11q13 region in human malignancies: Cyclin D1 and EMS1 are two new candidate oncogenes - a review. Gene 159(1):83-96.
    • (1995) Gene , vol.159 , Issue.1 , pp. 83-96
    • Schuuring, E.1
  • 11
    • 0037020196 scopus 로고    scopus 로고
    • The role of apoptosis in creating and maintaining luminal space within normal and oncogene-expressing mammary acini
    • Debnath J, et al. (2002) The role of apoptosis in creating and maintaining luminal space within normal and oncogene-expressing mammary acini. Cell 111(1):29-40.
    • (2002) Cell , vol.111 , Issue.1 , pp. 29-40
    • Debnath, J.1
  • 12
    • 79959448584 scopus 로고    scopus 로고
    • Examining the role of cyclin D1 in breast cancer
    • Velasco-Velázquez MA, et al. (2011) Examining the role of cyclin D1 in breast cancer. Future Oncol 7(6):753-765.
    • (2011) Future Oncol , vol.7 , Issue.6 , pp. 753-765
    • Velasco-Velázquez, M.A.1
  • 14
    • 0037218866 scopus 로고    scopus 로고
    • P53 and cyclin D1 as prognostic factors in squamous cell carcinoma of the larynx
    • Vielba R, et al. (2003) p53 and cyclin D1 as prognostic factors in squamous cell carcinoma of the larynx. Laryngoscope 113(1):167-172.
    • (2003) Laryngoscope , vol.113 , Issue.1 , pp. 167-172
    • Vielba, R.1
  • 15
    • 84863716004 scopus 로고    scopus 로고
    • Characterisation of amplification patterns and target genes at chromosome 11q13 in CCND1-amplified sporadic and familial breast tumours
    • Holm K, et al. (2012) Characterisation of amplification patterns and target genes at chromosome 11q13 in CCND1-amplified sporadic and familial breast tumours. Breast Cancer Res Treat 133(2):583-594.
    • (2012) Breast Cancer Res Treat , vol.133 , Issue.2 , pp. 583-594
    • Holm, K.1
  • 16
    • 33750362122 scopus 로고    scopus 로고
    • Molecular cytogenetic characterization of the 11q13 amplicon in head and neck squamous cell carcinoma
    • Jin C, et al. (2006) Molecular cytogenetic characterization of the 11q13 amplicon in head and neck squamous cell carcinoma. Cytogenet Genome Res 115(2):99-106.
    • (2006) Cytogenet Genome Res , vol.115 , Issue.2 , pp. 99-106
    • Jin, C.1
  • 17
    • 0037143750 scopus 로고    scopus 로고
    • High-resolution mapping of the 11q13 amplicon and identification of a gene, TAOS1, that is amplified and overexpressed in oral cancer cells
    • Huang X, Gollin SM, Raja S, Godfrey TE (2002) High-resolution mapping of the 11q13 amplicon and identification of a gene, TAOS1, that is amplified and overexpressed in oral cancer cells. Proc Natl Acad Sci USA 99(17):11369-11374.
    • (2002) Proc Natl Acad Sci USA , vol.99 , Issue.17 , pp. 11369-11374
    • Huang, X.1    Gollin, S.M.2    Raja, S.3    Godfrey, T.E.4
  • 18
    • 84866143707 scopus 로고    scopus 로고
    • Inhibition of Ca(2+)-activated Cl(-) channel ANO1/TMEM16A expression suppresses tumor growth and invasiveness in human prostate carcinoma
    • Liu W, Lu M, Liu B, Huang Y, Wang K (2012) Inhibition of Ca(2+)-activated Cl(-) channel ANO1/TMEM16A expression suppresses tumor growth and invasiveness in human prostate carcinoma. Cancer Lett 326(1):41-51.
    • (2012) Cancer Lett , vol.326 , Issue.1 , pp. 41-51
    • Liu, W.1    Lu, M.2    Liu, B.3    Huang, Y.4    Wang, K.5
  • 19
    • 55249091085 scopus 로고    scopus 로고
    • TMEM16A confers receptor-activated calcium-dependent chloride conductance
    • Yang YD, et al. (2008) TMEM16A confers receptor-activated calcium-dependent chloride conductance. Nature 455(7217):1210-1215.
    • (2008) Nature , vol.455 , Issue.7217 , pp. 1210-1215
    • Yang, Y.D.1
  • 20
    • 51549120559 scopus 로고    scopus 로고
    • Expression cloning of TMEM16A as a calcium-activated chloride channel subunit
    • Schroeder BC, Cheng T, Jan YN, Jan LY (2008) Expression cloning of TMEM16A as a calcium-activated chloride channel subunit. Cell 134(6):1019-1029.
    • (2008) Cell , vol.134 , Issue.6 , pp. 1019-1029
    • Schroeder, B.C.1    Cheng, T.2    Jan, Y.N.3    Jan, L.Y.4
  • 21
    • 54949112835 scopus 로고    scopus 로고
    • TMEM16A, a membrane protein associated with calciumdependent chloride channel activity
    • Caputo A, et al. (2008) TMEM16A, a membrane protein associated with calciumdependent chloride channel activity. Science 322(5901):590-594.
    • (2008) Science , vol.322 , Issue.5901 , pp. 590-594
    • Caputo, A.1
  • 22
    • 83455199984 scopus 로고    scopus 로고
    • LXXXV: Calcium-activated chloride channels
    • International Union of Basic and Clinical Pharmacology
    • Huang F, Wong X, Jan LY (2012) International Union of Basic and Clinical Pharmacology. LXXXV: Calcium-activated chloride channels. Pharmacol Rev 64(1): 1-15.
    • (2012) Pharmacol Rev , vol.64 , Issue.1 , pp. 1-15
    • Huang, F.1    Wong, X.2    Jan, L.Y.3
  • 23
    • 84862896642 scopus 로고    scopus 로고
    • The calcium-activated chloride channel anoctamin 1 acts as a heat sensor in nociceptive neurons
    • Cho H, et al. (2012) The calcium-activated chloride channel anoctamin 1 acts as a heat sensor in nociceptive neurons. Nat Neurosci 15(7):1015-1021.
    • (2012) Nat Neurosci , vol.15 , Issue.7 , pp. 1015-1021
    • Cho, H.1
  • 24
    • 78751478642 scopus 로고    scopus 로고
    • TMEM16A inhibitors reveal TMEM16A as a minor component of calcium-activated chloride channel conductance in airway and intestinal epithelial cells
    • NamkungW, Phuan PW, Verkman AS (2011) TMEM16A inhibitors reveal TMEM16A as a minor component of calcium-activated chloride channel conductance in airway and intestinal epithelial cells. J Biol Chem 286(3):2365-2374.
    • (2011) J Biol Chem , vol.286 , Issue.3 , pp. 2365-2374
    • Namkung, W.1    Phuan, P.W.2    Verkman, A.S.3
  • 25
    • 40849100330 scopus 로고    scopus 로고
    • Small-molecule screen identifies inhibitors of a human intestinal calcium-activated chloride channel
    • De La Fuente R, Namkung W, Mills A, Verkman AS (2008) Small-molecule screen identifies inhibitors of a human intestinal calcium-activated chloride channel. Mol Pharmacol 73(3):758-768.
    • (2008) Mol Pharmacol , vol.73 , Issue.3 , pp. 758-768
    • De La Fuente, R.1    Namkung, W.2    Mills, A.3    Verkman, A.S.4
  • 26
    • 84863228008 scopus 로고    scopus 로고
    • Novel 5-substituted benzyloxy-2-arylbenzofuran-3-carboxylic acids as calcium activated chloride channel inhibitors
    • Kumar S, Namkung W, Verkman AS, Sharma PK (2012) Novel 5-substituted benzyloxy-2-arylbenzofuran-3-carboxylic acids as calcium activated chloride channel inhibitors. Bioorg Med Chem 20(14):4237-4244.
    • (2012) Bioorg Med Chem , vol.20 , Issue.14 , pp. 4237-4244
    • Kumar, S.1    Namkung, W.2    Verkman, A.S.3    Sharma, P.K.4
  • 27
    • 77955983967 scopus 로고    scopus 로고
    • ANO1 amplification and expression in HNSCC with a high propensity for future distant metastasis and its functions in HNSCC cell lines
    • Ayoub C, et al. (2010) ANO1 amplification and expression in HNSCC with a high propensity for future distant metastasis and its functions in HNSCC cell lines. Br J Cancer 103(5):715-726.
    • (2010) Br J Cancer , vol.103 , Issue.5 , pp. 715-726
    • Ayoub, C.1
  • 28
    • 84863586989 scopus 로고    scopus 로고
    • TMEM16A induces MAPK and contributes directly to tumorigenesis and cancer progression
    • Duvvuri U, et al. (2012) TMEM16A induces MAPK and contributes directly to tumorigenesis and cancer progression. Cancer Res 72(13):3270-3281.
    • (2012) Cancer Res , vol.72 , Issue.13 , pp. 3270-3281
    • Duvvuri, U.1
  • 29
    • 84865078006 scopus 로고    scopus 로고
    • Enhanced expression of ANO1 in head and neck squamous cell carcinoma causes cell migration and correlates with poor prognosis
    • Ruiz C, et al. (2012) Enhanced expression of ANO1 in head and neck squamous cell carcinoma causes cell migration and correlates with poor prognosis. PLoS ONE 7(8): e43265.
    • (2012) PLoS ONE , vol.7 , Issue.8
    • Ruiz, C.1
  • 30
    • 18544379034 scopus 로고    scopus 로고
    • Gene amplification profiling of esophageal squamous cell carcinomas by DNA array CGH
    • Ishizuka T, et al. (2002) Gene amplification profiling of esophageal squamous cell carcinomas by DNA array CGH. Biochem Biophys Res Commun 296(1):152-155.
    • (2002) Biochem Biophys Res Commun , vol.296 , Issue.1 , pp. 152-155
    • Ishizuka, T.1
  • 31
    • 79959841849 scopus 로고    scopus 로고
    • Fine mapping of a region of chromosome 11q13 reveals multiple independent loci associated with risk of prostate cancer
    • Chung CC, et al. (2011) Fine mapping of a region of chromosome 11q13 reveals multiple independent loci associated with risk of prostate cancer. Hum Mol Genet 20(14):2869-2878.
    • (2011) Hum Mol Genet , vol.20 , Issue.14 , pp. 2869-2878
    • Chung, C.C.1
  • 32
    • 33845291140 scopus 로고    scopus 로고
    • Novel patterns of genome rearrangement and their association with survival in breast cancer
    • Hicks J, et al. (2006) Novel patterns of genome rearrangement and their association with survival in breast cancer. Genome Res 16(12):1465-1479.
    • (2006) Genome Res , vol.16 , Issue.12 , pp. 1465-1479
    • Hicks, J.1
  • 33
    • 0032506514 scopus 로고    scopus 로고
    • Calcium promotes cell survival through CaM-K kinase activation of the protein-kinase-B pathway
    • Yano S, Tokumitsu H, Soderling TR (1998) Calcium promotes cell survival through CaM-K kinase activation of the protein-kinase-B pathway. Nature 396(6711):584-587.
    • (1998) Nature , vol.396 , Issue.6711 , pp. 584-587
    • Yano, S.1    Tokumitsu, H.2    Soderling, T.R.3
  • 34
    • 84861527388 scopus 로고    scopus 로고
    • The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups
    • METABRIC Group
    • Curtis C, et al.; METABRIC Group (2012) The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups. Nature 486(7403):346-352.
    • (2012) Nature , vol.486 , Issue.7403 , pp. 346-352
    • Curtis, C.1
  • 35
    • 61949377514 scopus 로고    scopus 로고
    • Targeting ion channels in cancer: A novel frontier in antineoplastic therapy
    • Arcangeli A, et al. (2009) Targeting ion channels in cancer: A novel frontier in antineoplastic therapy. Curr Med Chem 16(1):66-93.
    • (2009) Curr Med Chem , vol.16 , Issue.1 , pp. 66-93
    • Arcangeli, A.1
  • 37
    • 51349165326 scopus 로고    scopus 로고
    • Ca(2+)/calmodulin-dependent protein kinases
    • Swulius MT, Waxham MN (2008) Ca(2+)/calmodulin-dependent protein kinases. Cell Mol Life Sci 65(17):2637-2657.
    • (2008) Cell Mol Life Sci , vol.65 , Issue.17 , pp. 2637-2657
    • Swulius, M.T.1    Waxham, M.N.2
  • 38
    • 77954522731 scopus 로고    scopus 로고
    • Calmodulin-dependent kinase II mediates vascular smooth muscle cell proliferation and is potentiated by extracellular signal regulated kinase
    • Cipolletta E, et al. (2010) Calmodulin-dependent kinase II mediates vascular smooth muscle cell proliferation and is potentiated by extracellular signal regulated kinase. Endocrinology 151(6):2747-2759.
    • (2010) Endocrinology , vol.151 , Issue.6 , pp. 2747-2759
    • Cipolletta, E.1
  • 39
    • 0030032998 scopus 로고    scopus 로고
    • Stimulation of growth factor receptor signal transduction by activation of voltage-sensitive calcium channels
    • Rosen LB, Greenberg ME (1996) Stimulation of growth factor receptor signal transduction by activation of voltage-sensitive calcium channels. Proc Natl Acad Sci USA 93(3):1113-1118.
    • (1996) Proc Natl Acad Sci USA , vol.93 , Issue.3 , pp. 1113-1118
    • Rosen, L.B.1    Greenberg, M.E.2
  • 40
    • 0035500067 scopus 로고    scopus 로고
    • Potassium channel blocker activates extracellular signalregulated kinases through Pyk2 and epidermal growth factor receptor in rat cardiomyocytes
    • Tahara S, et al. (2001) Potassium channel blocker activates extracellular signalregulated kinases through Pyk2 and epidermal growth factor receptor in rat cardiomyocytes. J Am Coll Cardiol 38(5):1554-1563.
    • (2001) J Am Coll Cardiol , vol.38 , Issue.5 , pp. 1554-1563
    • Tahara, S.1
  • 41
    • 0030837027 scopus 로고    scopus 로고
    • The m1 muscarinic acetylcholine receptor transactivates the EGF receptor to modulate ion channel activity
    • Tsai W, Morielli AD, Peralta EG (1997) The m1 muscarinic acetylcholine receptor transactivates the EGF receptor to modulate ion channel activity. EMBO J 16(15): 4597-4605.
    • (1997) EMBO J , vol.16 , Issue.15 , pp. 4597-4605
    • Tsai, W.1    Morielli, A.D.2    Peralta, E.G.3
  • 42
    • 84860370783 scopus 로고    scopus 로고
    • Trpc1 ion channel modulates phosphatidylinositol 3-kinase/Akt pathway during myoblast differentiation and muscle regeneration
    • Zanou N, et al. (2012) Trpc1 ion channel modulates phosphatidylinositol 3-kinase/Akt pathway during myoblast differentiation and muscle regeneration. J Biol Chem 287(18):14524-14534.
    • (2012) J Biol Chem , vol.287 , Issue.18 , pp. 14524-14534
    • Zanou, N.1
  • 43
    • 33846056925 scopus 로고    scopus 로고
    • Substrate selectivity of epidermal growth factor-receptor ligand sheddases and their regulation by phorbol esters and calcium influx
    • Horiuchi K, et al. (2007) Substrate selectivity of epidermal growth factor-receptor ligand sheddases and their regulation by phorbol esters and calcium influx. Mol Biol Cell 18(1):176-188.
    • (2007) Mol Biol Cell , vol.18 , Issue.1 , pp. 176-188
    • Horiuchi, K.1
  • 44
    • 77952299611 scopus 로고    scopus 로고
    • The Src, Syk, and Tec family kinases: Distinct types of molecular switches
    • Bradshaw JM (2010) The Src, Syk, and Tec family kinases: Distinct types of molecular switches. Cell Signal 22(8):1175-1184.
    • (2010) Cell Signal , vol.22 , Issue.8 , pp. 1175-1184
    • Bradshaw, J.M.1
  • 45
    • 84255167151 scopus 로고    scopus 로고
    • Membrane depolarization is the trigger for PI3K/Akt activation and leads to the generation of ROS
    • Chatterjee S, et al. (2012) Membrane depolarization is the trigger for PI3K/Akt activation and leads to the generation of ROS. Am J Physiol Heart Circ Physiol 302(1): H105-H114.
    • (2012) Am J Physiol Heart Circ Physiol , vol.302 , Issue.1
    • Chatterjee, S.1
  • 46
    • 0026594101 scopus 로고
    • Epidermal growth factor activates calcium channels by phospholipase A2/5-lipoxygenase-mediated leukotriene C4 production
    • Peppelenbosch MP, Tertoolen LG, den Hertog J, de Laat SW (1992) Epidermal growth factor activates calcium channels by phospholipase A2/5-lipoxygenase- mediated leukotriene C4 production. Cell 69(2):295-303.
    • (1992) Cell , vol.69 , Issue.2 , pp. 295-303
    • Peppelenbosch, M.P.1    Tertoolen, L.G.2    Den Hertog, J.3    De Laat, S.W.4
  • 47
    • 52649167980 scopus 로고    scopus 로고
    • EGF mediates calciumactivated chloride channel activation in the human bronchial epithelial cell line 16HBE14o-: Involvement of tyrosine kinase p60c-src
    • Jeulin C, Seltzer V, Bailbé D, Andreau K, Marano F (2008) EGF mediates calciumactivated chloride channel activation in the human bronchial epithelial cell line 16HBE14o-: Involvement of tyrosine kinase p60c-src. Am J Physiol Lung Cell Mol Physiol 295(3):L489-L496.
    • (2008) Am J Physiol Lung Cell Mol Physiol , vol.295 , Issue.3
    • Jeulin, C.1    Seltzer, V.2    Bailbé, D.3    Andreau, K.4    Marano, F.5
  • 48
    • 84859710006 scopus 로고    scopus 로고
    • Epidermal growth factor chronically upregulates Ca(2+)-dependent Cl(-) conductance and TMEM16A expression in intestinal epithelial cells
    • Mroz MS, Keely SJ (2012) Epidermal growth factor chronically upregulates Ca(2+)-dependent Cl(-) conductance and TMEM16A expression in intestinal epithelial cells. J Physiol 590(Pt 8):1907-1920.
    • (2012) J Physiol , vol.590 , Issue.PART 8 , pp. 1907-1920
    • Mroz, M.S.1    Keely, S.J.2
  • 49
    • 0029121267 scopus 로고
    • Potentiation of epidermal growth factor receptor-mediated oncogenesis by c-Src: Implications for the etiology of multiple human cancers
    • Maa MC, Leu TH, McCarley DJ, Schatzman RC, Parsons SJ (1995) Potentiation of epidermal growth factor receptor-mediated oncogenesis by c-Src: Implications for the etiology of multiple human cancers. Proc Natl Acad Sci USA 92(15):6981-6985.
    • (1995) Proc Natl Acad Sci USA , vol.92 , Issue.15 , pp. 6981-6985
    • Maa, M.C.1    Leu, T.H.2    McCarley, D.J.3    Schatzman, R.C.4    Parsons, S.J.5
  • 50
    • 84862980716 scopus 로고    scopus 로고
    • Anoctamin 1 (Tmem16A) Ca2+-activated chloride channel stoichiometrically interacts with an ezrin-radixin-moesin network
    • Perez-Cornejo P, et al. (2012) Anoctamin 1 (Tmem16A) Ca2+-activated chloride channel stoichiometrically interacts with an ezrin-radixin-moesin network. Proc Natl Acad Sci USA 109(26):10376-10381.
    • (2012) Proc Natl Acad Sci USA , vol.109 , Issue.26 , pp. 10376-10381
    • Perez-Cornejo, P.1
  • 51
    • 70349436013 scopus 로고    scopus 로고
    • Prognostic significance of epidermal growth factor receptor phosphorylation and mutation in head and neck squamous cell carcinoma
    • Hama T, et al. (2009) Prognostic significance of epidermal growth factor receptor phosphorylation and mutation in head and neck squamous cell carcinoma. Oncologist 14(9):900-908.
    • (2009) Oncologist , vol.14 , Issue.9 , pp. 900-908
    • Hama, T.1
  • 52
    • 84859872673 scopus 로고    scopus 로고
    • Tumor epidermal growth factor receptor and EGFR PY1068 are independent prognostic indicators for head and neck squamous cell carcinoma
    • Wheeler S, et al. (2012) Tumor epidermal growth factor receptor and EGFR PY1068 are independent prognostic indicators for head and neck squamous cell carcinoma. Clin Cancer Res 18(8):2278-2289.
    • (2012) Clin Cancer Res , vol.18 , Issue.8 , pp. 2278-2289
    • Wheeler, S.1
  • 53
    • 55749100008 scopus 로고    scopus 로고
    • Expression of the epidermal growth factor receptor (EGFR) and the phosphorylated EGFR in invasive breast carcinomas
    • Magkou C, et al. (2008) Expression of the epidermal growth factor receptor (EGFR) and the phosphorylated EGFR in invasive breast carcinomas. Breast Cancer Res 10(3):R49.
    • (2008) Breast Cancer Res , vol.10 , Issue.3
    • Magkou, C.1
  • 54
    • 84862303981 scopus 로고    scopus 로고
    • Role of phosphatidylinositol-3-kinase pathway in head and neck squamous cell carcinoma
    • Du L, Shen J, Weems A, Lu SL (2012) Role of phosphatidylinositol-3-kinase pathway in head and neck squamous cell carcinoma. J Oncol 2012:450179.
    • (2012) J Oncol , vol.2012 , pp. 450179
    • Du, L.1    Shen, J.2    Weems, A.3    Lu, S.L.4
  • 56
    • 84861805678 scopus 로고    scopus 로고
    • The molecular pathogenesis of head and neck squamous cell carcinoma
    • Rothenberg SM, Ellisen LW (2012) The molecular pathogenesis of head and neck squamous cell carcinoma. J Clin Invest 122(6):1951-1957.
    • (2012) J Clin Invest , vol.122 , Issue.6 , pp. 1951-1957
    • Rothenberg, S.M.1    Ellisen, L.W.2
  • 57
    • 84859169877 scopus 로고    scopus 로고
    • The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity
    • Barretina J, et al. (2012) The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity. Nature 483(7391):603-607.
    • (2012) Nature , vol.483 , Issue.7391 , pp. 603-607
    • Barretina, J.1
  • 58
    • 79961232797 scopus 로고    scopus 로고
    • The split-apply-combine strategy for data analysis
    • Wickham H (2011) The split-apply-combine strategy for data analysis. J Stat Softw40(1): 1-29.
    • (2011) J Stat Softw , vol.40 , Issue.1 , pp. 1-29
    • Wickham, H.1
  • 59
    • 62649174944 scopus 로고    scopus 로고
    • QPatch: The missing link between HTS and ion channel drug discovery
    • Mathes C, Friis S, Finley M, Liu Y (2009) QPatch: The missing link between HTS and ion channel drug discovery. Comb Chem High Throughput Screen 12(1):78-95.
    • (2009) Comb Chem High Throughput Screen , vol.12 , Issue.1 , pp. 78-95
    • Mathes, C.1    Friis, S.2    Finley, M.3    Liu, Y.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.