Mapping of long-range INS promoter interactions reveals a role for calcium-activated chloride channel ANO1 in insulin secretion

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 47, 2014, Pages 16760-16765

  Xu, Zhixiong ^a   Lefevre, Gaelle M ^a   Gavrilova, Oksana ^a   St Claire, Mark B Foster ^a   Riddick, Gregory ^a   Felsenfeld, Gary ^a  

^a NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

Author keywords

Chloride channel; Diabetes; Insulin secretion

Indexed keywords

CALCIUM ACTIVATED CHLORIDE CHANNEL; CALCIUM ACTIVATED CHLORIDE CHANNEL ANO1; FAT; GLUCOSE; INSULIN; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; ANO1 PROTEIN, HUMAN; CHLORIDE CHANNEL; TUMOR PROTEIN;

ANIMAL EXPERIMENT; ARTICLE; CELL NUCLEUS; CHROMATIN CONFORMATION CAPTURE; CHROMATIN STRUCTURE; CHROMOSOME 11; CONTROLLED STUDY; FEEDBACK SYSTEM; GENE EXPRESSION; GENE FUNCTION; GENE MAPPING; GENE TARGETING; GENETIC TRANSCRIPTION; GLUCOSE METABOLISM; HUMAN; HUMAN CELL; HUMAN CHROMOSOME; INSULIN BLOOD LEVEL; INSULIN METABOLISM; INSULIN RELEASE; LIPID DIET; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PROMOTER REGION; PROTEIN CONFORMATION; SERUM; ANIMAL; GENETICS; KNOCKOUT MOUSE; METABOLISM; PANCREAS ISLET; PHYSIOLOGY; POLYMERASE CHAIN REACTION; SECRETION (PROCESS);

MUS;

ANIMALS; CHLORIDE CHANNELS; GLUCOSE; HUMANS; INSULIN; ISLETS OF LANGERHANS; MICE; MICE, KNOCKOUT; NEOPLASM PROTEINS; POLYMERASE CHAIN REACTION; PROMOTER REGIONS, GENETIC;

EID: 84912535339     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1419240111     Document Type: Article

References (45)

1. Lieberman-Aiden E, et al. (2009) Comprehensive mapping of long-range interactions reveals folding principles of the human genome. Science 326 (5950) : 289-293.
2. Hou C, Li L, Qin ZS, Corces VG (2012) Gene density, transcription, and insulators contribute to the partition of the Drosophila genome into physical domains. Mol Cell 48 (3) : 471-484.
3. Sexton T, et al. (2012) Three-dimensional folding and functional organization principles of the Drosophila genome. Cell 148 (3) : 458-472.
4. Dixon JR, et al. (2012) Topological domains in mammalian genomes identified by analysis of chromatin interactions. Nature 485 (7398) : 376-380.
5. Dunham I, et al.; ENCODE Project Consortium (2012) An integrated encyclopedia of DNA elements in the human genome. Nature 489 (7414) : 57-74.
6. Sanyal A, Lajoie BR, Jain G, Dekker J (2012) The long-range interaction landscape of gene promoters. Nature 489 (7414) : 109-113.
7. Nora EP, et al. (2012) Spatial partitioning of the regulatory landscape of the Xinactivation centre. Nature 485 (7398) : 381-385.
8. Cheutin T, Bantignies F, Leblanc B, Cavalli G (2010) Chromatin folding: From linear chromosomes to the 4D nucleus. Cold Spring Harb Symp Quant Biol 75: 461-473.
9. Göndör A, Ohlsson R (2009) Chromosome crosstalk in three dimensions. Nature 461 (7261) : 212-217.
10. Li G, et al. (2012) Extensive promoter-centered chromatin interactions provide a topological basis for transcription regulation. Cell 148 (1-2) : 84-98.
11. Hughes JR, et al. (2014) Analysis of hundreds of cis-regulatory landscapes at high resolution in a single, high-Throughput experiment. Nat Genet 46 (2) : 205-212.
12. Xu Z, Lefevre GM, Felsenfeld G (2012) Chromatin structure, epigenetic mechanisms and long-range interactions in the human insulin locus. Diabetes Obes Metab 14 (Suppl 3) : 1-11.
13. French JD, et al.; GENICA Network; kConFab Investigators (2013) Functional variants at the 11q13 risk locus for breast cancer regulate cyclin D1 expression through longrange enhancers. Am J Hum Genet 92 (4) : 489-503.
14. Xu Z, Wei G, Chepelev I, Zhao K, Felsenfeld G (2011) Mapping of INS promoter interactions reveals its role in long-range regulation of SYT8 transcription. Nat Struct Mol Biol 18 (3) : 372-378.
15. Harismendy O, et al. (2011) 9p21 DNA variants associated with coronary artery disease impair interferon-? signalling response. Nature 470 (7333) : 264-268.
16. Edlund A, Esguerra JL, Wendt A, Flodström-Tullberg M, Eliasson L (2014) CFTR and Anoctamin 1 (ANO1) contribute to camp-Amplified exocytosis and insulin secretion in human and murine pancreatic beta-cells. BMC Med 12 (1) : 87.
17. Schroeder BC, Cheng T, Jan YN, Jan LY (2008) Expression cloning of TMEM16A as a calcium-Activated chloride channel subunit. Cell 134 (6) : 1019-1029.
18. Yang YD, et al. (2008) TMEM16A confers receptor-Activated calcium-dependent chloride conductance. Nature 455 (7217) : 1210-1215.
19. Caputo A, et al. (2008) TMEM16A, a membrane protein associated with calciumdependent chloride channel activity. Science 322 (5901) : 590-594.
20. Best L (2005) Glucose-induced electrical activity in rat pancreatic beta-cells: Dependence on intracellular chloride concentration. J Physiol 568 (Pt 1) : 137-144.
21. Sehlin J (1978) Interrelationship between chloride fluxes in pancreatic islets and insulin release. Am J Physiol 235 (5) : E501-E508.
22. 2+ signalling in glucose-stimulated pancreatic beta-cells. Cell Signal 12 (11-12) : 781-786.
23. Malaisse WJ, Zhang Y, Louchami K, Jijakli H (2004) Stimulation by D-glucose of 36Cl-efflux from prelabeled rat pancreatic islets. Endocrine 25 (1) : 23-25.
24. Best L, Brown PD, Sener A, Malaisse WJ (2010) Electrical activity in pancreatic islet cells: The VRAC hypothesis. Islets 2 (2) : 59-64.
25. Henquin JC, Nenquin M, Ravier MA, Szollosi A (2009) Shortcomings of current models of glucose-induced insulin secretion. Diabetes Obes Metab 11 (Suppl 4) : 168-179.
26. Almaça J, et al. (2009) TMEM16 proteins produce volume-regulated chloride currents that are reduced in mice lacking TMEM16A. J Biol Chem 284 (42) : 28571-28578.
27. Duran C, Hartzell HC (2011) Physiological roles and diseases of Tmem16/Anoctamin proteins: Are they all chloride channels? Acta Pharmacol Sin 32 (6) : 685-692.
28. Hanzu FA, et al. (2012) Expression of TMEM16A and SLC4A4 in human pancreatic islets. Cell Physiol Biochem 29 (1-2) : 61-64.
29. Schreiber R, et al. (2010) Expression and function of epithelial anoctamins. J Biol Chem 285 (10) : 7838-7845.
30. Gershengorn MC, et al. (2004) Epithelial-To-mesenchymal transition generates proliferative human islet precursor cells. Science 306 (5705) : 2261-2264.
31. 2+-Activated Cl-currents in cerebral artery smooth muscle cells. Am J Physiol Heart Circ Physiol 301 (5) : H1819-H1827.
32. 2+-Activated chloride channel stoichiometrically interacts with an ezrin-radixin-moesin network. Proc Natl Acad Sci USA 109 (26) : 10376-10381.
33. Namkung W, Yao Z, Finkbeiner WE, Verkman AS (2011) Small-molecule activators of TMEM16A, a calcium-Activated chloride channel, stimulate epithelial chloride secretion and intestinal contraction. FASEB J 25 (11) : 4048-4062.
34. Namkung W, Phuan PW, Verkman AS (2011) TMEM16A inhibitors reveal TMEM16A as a minor component of calcium-Activated chloride channel conductance in airway and intestinal epithelial cells. J Biol Chem 286 (3) : 2365-2374.
35. + channels. J Biol Chem 282 (3) : 1747-1756.
36. Henquin JC, et al. (2011) In vitro insulin secretion by pancreatic tissue from infants with diazoxide-resistant congenital hyperinsulinism deviates from model predictions. J Clin Invest 121 (10) : 3932-3942.
37. Huang F, Wong X, Jan LY (2012) International Union of Basic and Clinical Pharmacology. LXXXV: Calcium-Activated chloride channels. Pharmacol Rev 64 (1) : 1-15.
38. Nakagawa Y, et al.; Bart's-Oxford Family Study Group (1998) Fine mapping of the diabetes-susceptibility locus, IDDM4, on chromosome 11q13. Am J Hum Genet 63 (2) : 547-556.
39. Eckenrode S, et al. (2000) Fine-mapping of the type 1 diabetes locus (IDDM4) on chromosome 11q and evaluation of two candidate genes (FADD and GALN) by affected sibpair and linkage-disequilibrium analyses. Hum Genet 106 (1) : 14-18.
40. Hashimoto L, et al. (1994) Genetic mapping of a susceptibility locus for insulindependent diabetes mellitus on chromosome 11q. Nature 371 (6493) : 161-164.
41. Davies JL, et al. (1994) A genome-wide search for human type 1 diabetes susceptibility genes. Nature 371 (6493) : 130-136.
42. Concannon P, et al. (1998) A second-generation screen of the human genome for susceptibility to insulin-dependent diabetes mellitus. Nat Genet 19 (3) : 292-296.
43. Noble JA, Erlich HA (2012) Genetics of type 1 diabetes. Cold Spring Harb Perspect Med 2 (1) : A007732.
44. Veit G, et al. (2012) Proinflammatory cytokine secretion is suppressed by TMEM16A or CFTR channel activity in human cystic fibrosis bronchial epithelia. Mol Biol Cell 23 (21) : 4188-4202.
45. Abu-El-Haija M, et al. (2011) An activated immune and inflammatory response targets the pancreas of newborn pigs with cystic fibrosis. Pancreatology 11 (5) : 506-515.