Increased TMEM16A-encoded calcium-activated chloride channel activity is associated with pulmonary hypertension

American Journal of Physiology - Cell Physiology

Volumn 303, Issue 12, 2012, Pages

  Forrest, Abigail S ^a   Joyce, Talia C ^a   Huebner, Marissa L ^a   Ayon, Ramon J ^a   Wiwchar, Michael ^a   Joyce, John ^a   Freitas, Natalie ^a   Davis, Alison J ^b   Ye, Linda ^a   Duan, Dayue D ^a   Singer, Cherie A ^a   Valencik, Maria L ^a   Greenwood, Iain A ^b   Leblanc, Normand ^a  

^a UNIVERSITY OF NEVADA SCHOOL OF MEDICINE   (United States)

^b ST GEORGE'S UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

Anoctamin 1; Ca2+ activated Cl channel; Patch clamp technique; Pulmonary arterial tone; TMEM16A

Indexed keywords

CALCIUM ACTIVATED CHLORIDE CHANNEL; CHLORIDE CHANNEL; CHLORIDE CHANNEL BLOCKING AGENT; INDOMETACIN; MESSENGER RNA; MONOCROTALINE; NIFEDIPINE; NIFLUMIC ACID; PROSTAGLANDIN SYNTHASE; PROTEIN TMEM16A; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERY BLOOD FLOW; ARTERY DIAMETER; ARTERY MUSCLE; ARTICLE; CHLORIDE CURRENT; CONTROLLED STUDY; DOPPLER FLOWMETRY; ENZYME INHIBITION; EXCITATION CONTRACTION COUPLING; EXPERIMENTAL MODEL; GENE; GENE EXPRESSION; HEART RIGHT VENTRICLE HYPERTROPHY; HEART WEIGHT; LUNG ARTERY; LUNG ARTERY PRESSURE; LUNG BLOOD FLOW; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PULMONARY HYPERTENSION; QUANTITATIVE ANALYSIS; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SMOOTH MUSCLE FIBER; TMEM16A GENE; WESTERN BLOTTING;

ANIMALS; CALCIUM CHANNEL BLOCKERS; CHLORIDE CHANNELS; CYCLOOXYGENASE INHIBITORS; HYPERTENSION, PULMONARY; HYPERTROPHY, RIGHT VENTRICULAR; INDOMETHACIN; MALE; MONOCROTALINE; MUSCLE, SMOOTH, VASCULAR; MYOCYTES, SMOOTH MUSCLE; NIFEDIPINE; NIFLUMIC ACID; PATCH-CLAMP TECHNIQUES; PULMONARY ARTERY; PYRIMIDINES; RATS; RATS, WISTAR; SEROTONIN; THIAZOLES;

ANIMALIA; RATTUS;

EID: 84871315406     PISSN: 03636143     EISSN: 15221563     Source Type: Journal    
DOI: 10.1152/ajpcell.00044.2012     Document Type: Article

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