Anoctamins

Pflugers Archiv European Journal of Physiology

Volumn 462, Issue 2, 2011, Pages 195-208

  Kunzelmann, Karl ^a   Tian, Yuemin ^a   Martins, Joana Raquel ^a   Faria, Diana ^a   Kongsuphol, Patthara ^a   Ousingsawat, Jiraporn ^a   Thevenod, Frank ^b   Roussa, Eleni ^c   Rock, Jason ^d   Schreiber, Rainer ^a  

^a UNIVERSITY OF REGENSBURG   (Germany)

^b UNIVERSITY OF WITTEN HERDECKE   (Germany)

^c UNIVERSITY OF FREIBURG   (Germany)

^d DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Ano 1; Anoctamin; Ca 2+ activated Cl currents; CaCC; Cancer; Cystic fibrosis; Development, SHH; Proliferation; TMEM16A; TMEM16B; TMEM16E; TMEM16F; TMEM16G; TMEM16H; TMEM16J; TMEM16K

Indexed keywords

ANOCTAMIN; CALCIUM ACTIVATED CHLORIDE CHANNEL; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE; CALCIUM ION; CALMODULIN; CHLORIDE CHANNEL; CHLORIDE ION; CYCLIC AMP DEPENDENT PROTEIN KINASE; PROTEIN KINASE C; UNCLASSIFIED DRUG;

CARCINOGENESIS; CELL VOLUME; CHANNEL GATING; CHLORIDE CURRENT; DIMERIZATION; HUMAN; METASTASIS POTENTIAL; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN INTERACTION; PROTEIN PHOSPHORYLATION; PROTEIN STRUCTURE; REVIEW;

ANIMALS; CALCIUM; CHLORIDE CHANNELS; HUMANS; MEMBRANE PROTEINS; MODELS, MOLECULAR; RECEPTORS, CELL SURFACE;

EID: 80051557261     PISSN: 00316768     EISSN: 14322013     Source Type: Journal    
DOI: 10.1007/s00424-011-0975-9     Document Type: Review

References (123)

1. J Almaca Y Tian F AlDehni J Ousingsawat P Kongsuphol JR Rock BD Harfe R Schreiber K Kunzelmann 2009 TMEM16 proteins produce volume regulated chloride currents that are reduced in mice lacking TMEM16A J Biol Chem 284 28571 28578 19654323 1:CAS:528:DC%2BD1MXht1Cmt77N
2. MP Anderson MJ Welsh 1991 Calcium and cAMP activate different chloride channels in the apical membrane of normal and cystic fibrosis epithelia Proc Natl Acad Sci USA 88 6003 6007 1712478 1:CAS:528:DyaK3MXlvVSktrs%3D (Pubitemid 21914874)
3. C Ardeleanu D Arsene M Hinescu F Andrei D Gutu L Luca LM Popescu 2009 Pancreatic expression of DOG1: a novel gastrointestinal stromal tumor (GIST) biomarker Appl Immunohistochem Mol Morphol 17 413 418 19417627 1:CAS:528:DC%2BD1MXhtFGku77P
4. C Ayoub C Wasylyk Y Li E Thomas L Marisa A Robe M Roux J Abecassis A de Reynies B Wasylyk 2010 ANO 1 amplification and expression in HNSCC with a high propensity for future distant metastasis and its functions in HNSCC cell lines Br J Cancer 103 715 726 20664600 1:CAS:528:DC%2BC3cXhtVKgsLzO
5. JM Ball P Tian CQ Zeng AP Morris MK Estes 1996 Age-dependent diarrhea induced by a rotaviral nonstructural glycoprotein Science 272 101 104 8600515 1:CAS:528:DyaK28XitVKktL0%3D (Pubitemid 26110759)
6. TK Bera S Das H Maeda R Beers CD Wolfgang V Kumar Y Hahn B Lee I Pastan 2004 NGEP, a gene encoding a membrane protein detected only in prostate cancer and normal prostate Proc Natl Acad Sci USA 101 3059 3064 14981236 1:CAS:528:DC%2BD2cXitlWht78%3D (Pubitemid 38327734)
7. Bergmann F, Andrulis M, Hartwig W, Penzel R, Gaida MM, Herpel E, Schirmacher P, and Mechtersheimer G (2011) Discovered on gastrointestinal stromal tumor 1 (DOG1) is expressed in pancreatic centroacinar cells and in solid-pseudopapillary neoplasms-novel evidence for a histogenetic relationship. Hum Pathol (in press)
8. Billig GM, Pál B, Fidzinski P, and Jentsch TJ (2011) Ca2+-activated Cl- currents are dispensable for olfaction. Nature Neurosc (in press)
9. V Bolduc G Marlow KM Boycott K Saleki H Inoue J Kroon M Itakura Y Robitaille L Parent F Baas K Mizuta N Kamata I Richard WH Linssen I Mahjneh M de Visser R Bashir B Brais 2010 Recessive mutations in the putative calcium-activated chloride channel anoctamin 5 cause proximal LGMD2L and distal MMD3 muscular dystrophies Am J Hum Genet 86 213 221 20096397 1:CAS:528:DC%2BC3cXlt1Kmu78%3D
10. PF Bove BR Grubb SF Okada CM Ribeiro TD Rogers SH Randell WK O'Neal RC Boucher 2010 Human alveolar type II cells secrete and absorb liquid in response to local nucleotide signaling J Biol Chem 285 34939 34949 20801871 1:CAS:528:DC%2BC3cXhtlGktbjP
11. DA Brown GM Passmore 2010 Some new insights into the molecular mechanisms of pain perception J Clin Invest 120 1380 1383 20424321 1:CAS:528: DC%2BC3cXlslSitrk%3D
12. A Caputo E Caci L Ferrera N Pedemonte C Barsanti E Sondo U Pfeffer R Ravazzolo O Zegarra-Moran LJ Galietta 2008 TMEM16A, a membrane protein associated with calcium-dependent chloride channel activity Science 322 590 594 18772398 1:CAS:528:DC%2BD1cXht1Krt7vN
13. A Carles R Millon A Cromer G Ganguli F Lemaire J Young C Wasylyk D Muller I Schultz Y Rabouel D Dembele C Zhao P Marchal C Ducray L Bracco J Abecassis O Poch B Wasylyk 2006 Head and neck squamous cell carcinoma transcriptome analysis by comprehensive validated differential display Oncogene 25 1821 1831 16261155 1:CAS:528:DC%2BD28XitlKntb4%3D
14. A Carneiro A Isinger A Karlsson J Johansson G Jonsson PO Bendahl D Falkenback B Halvarsson M Nilbert 2008 Prognostic impact of array-based genomic profiles in esophageal squamous cell cancer BMC Cancer 8 98 18405350
15. E Castoldi PW Collins PL Williamson EM Bevers 2011 Compound heterozygosity for 2 novel TMEM16F mutations in a patient with Scott syndrome Blood 117 4399 4400 21511967 1:CAS:528:DC%2BC3MXls1Ghsr8%3D
16. V Chappe DA Hinkson T Zhu XB Chang JR Riordan JW Hanrahan 2003 Phosphorylation of protein kinase C sites in NBD1 and the R domain control CFTR channel activation by PKA J Physiol 548 39 52 12588899 1:CAS:528: DC%2BD3sXjsVKju7Y%3D (Pubitemid 36410796)
17. Chen Y, An H, Li T, Liu Y, Gao C, Guo P, Zhang H, and Zhan Y (2011) Direct or Indirect Regulation of Calcium-Activated Chloride Channel by Calcium. J Membr Biol (in press)
18. LL Clarke KA Burns JY Bayle RC Boucher MR Van Scott 1992 Sodium- and chloride-conductive pathways in cultured mouse tracheal epithelium Am J Physiol 263 L519 L525 1443155 1:CAS:528:DyaK3sXjs1Ckug%3D%3D
19. S Das Y Hahn DA Walker S Nagata MC Willingham DM Peehl TK Bera B Lee I Pastan 2008 Topology of NGEP, a prostate-specific cell:cell junction protein widely expressed in many cancers of different grade level Cancer Res 68 6306 6312 18676855 1:CAS:528:DC%2BD1cXpt1WjsLY%3D
20. AJ Davis AS Forrest TA Jepps ML Valencik M Wiwchar CA Singer WR Sones IA Greenwood N Leblanc 2010 Expression profile and protein translation of TMEM16A in murine smooth muscle Am J Physiol Cell Physiol 299 C948 C959 20686072 1:CAS:528:DC%2BC3cXhsFSgu7vN
21. MJ Davis MA Hill 1999 Signaling mechanisms underlying the vascular myogenic response Physiol Rev 79 387 423 10221985 1:CAS:528:DyaK1MXivFektLc%3D (Pubitemid 29210926)
22. M Dutertre M Lacroix-Triki K Driouch P de la Grange L Gratadou S Beck S Millevoi J Tazi R Lidereau S Vagner D Auboeuf 2010 Exon-based clustering of murine breast tumor transcriptomes reveals alternative exons whose expression is associated with metastasis Cancer Res 70 896 905 20103641 1:CAS:528: DC%2BC3cXht12qsr8%3D
23. - channel activated by extracellular nucleotides, in biliary epithelium J Biol Chem 286 766 776 21041307
24. R Dutzler EB Campbell M Cadene BT Chait R MacKinnon 2002 X-ray structure of a ClC chloride channel at 3.0 A reveals the molecular basis of anion selectivity Nature 415 287 294 11796999 1:CAS:528:DC%2BD38XptlWksA%3D%3D (Pubitemid 34087544)
25. J Eggermont 2004 Calcium-activated chloride channels: (un)known, (un)loved? Proc Am Thorac Soc 1 22 27 16113407 1:CAS:528:DC%2BD2cXhs1Wluro%3D
26. I Espinosa CH Lee MK Kim BT Rouse S Subramanian K Montgomery S Varma CL Corless MC Heinrich KS Smith Z Wang B Rubin TO Nielsen RS Seitz DT Ross RB West ML Cleary M van de Rijn 2008 A novel monoclonal antibody against DOG1 is a sensitive and specific marker for gastrointestinal stromal tumors Am J Surg Pathol 32 210 218 18223323 (Pubitemid 351172135)
27. C Fahlke T Knittle CA Gurnett KP Campbell AL George Jr 1997 Subunit stoichiometry of human muscle chloride channels J Gen Physiol 109 93 104 8997668 1:CAS:528:DyaK2sXnsFSjuw%3D%3D (Pubitemid 27030196)
28. G Fallah T Roemer S Detro-Dassen U Braam F Markwardt G Schmalzing 2010 TMEM16A(a)/anoctamin-1 shares a homodimeric architecture with CLC chloride channels Mol Cell Proteomics 79 649 661
29. D Faria R Schreiber K Kunzelmann 2009 CFTR is activated through stimulation of purinergic P2Y2 receptors Pflügers Arch 457 1373 1380 19002711 1:CAS:528:DC%2BD1MXivFymsL8%3D
30. L Ferrera A Caputo LJ Galietta 2010 TMEM16A protein: a new identity for Ca(2+)-dependent Cl channels Physiology (Bethesda) 25 357 363 1:CAS:528:DC%2BC3MXitVSqt7o%3D
31. L Ferrera A Caputo I Ubby E Bussani O Zegarra-Moran R Ravazzolo F Pagani LJ Galietta 2009 Regulation of TMEM16A chloride channel properties by alternative splicing J Biol Chem 284 33360 33368 19819874 1:CAS:528: DC%2BD1MXhsVCjtb%2FM
32. Ferrera L, Scudieri P, Sondo E, Pedemonte N, Caci E, Ubby I, Pagani F, and Galietta LJ (2011) Native calcium activated chloride channels and their association with TMEM16A protein expression. 8th ECFS Basic Science Conference, 30 March-2 April, Tirennia, Italy (Abstract)
33. H Fischer B Illek L Sachs WE Finkbeiner JH Widdicombe 2010 CFTR and Ca-activated Cl channels in primary cultures of human airway gland cells of serous or mucous phenotype Am J Physiol Lung Cell Mol Physiol 299 L585 L594 20675434 1:CAS:528:DC%2BC3cXhtlKlu73E
34. - channels-homing in on an elusive channel species Prog Neurobiol 60 247 289 10658643 1:CAS:528:DC%2BD3cXkslalsQ%3D%3D
35. LJ Galietta 2009 The TMEM16 protein family: a new class of chloride channels? Biophys J 97 3047 3053 20006941 1:CAS:528:DC%2BC3cXksFajtQ%3D%3D
36. PJ Gomez-Pinilla SJ Gibbons MR Bardsley A Lorincz MJ Pozo PJ Pasricha M van de Rijn RB West MG Sarr ML Kendrick RR Cima EJ Dozois DW Larson T Ordog G Farrugia 2009 Ano 1 is a selective marker of interstitial cells of Cajal in the human and mouse gastrointestinal tract Am J Physiol Gastrointest Liver Physiol 296 G1370 G1381 19372102 1:CAS:528:DC%2BD1MXnsVClu7k%3D
37. A Gritli-Linde SF Vaziri JR Rock K Hallberg D Iribarne BD Harfe A Linde 2009 Expression patterns of the Tmem16 gene family during cephalic development in the mouse Gene Expr Patterns 9 178 191 19059364 1:CAS:528: DC%2BD1MXhtFelsb4%3D
38. HC Hartzell I Putzier J Arreola 2005 Calcium-activated chloride channels Annu Rev Physiol 67 719 758 15709976 1:CAS:528:DC%2BD2MXjsFeks7g%3D (Pubitemid 40404508)
39. Q He ST Halm J Zhang DR Halm 2011 Activation of the basolateral membrane Cl conductance essential for electrogenic K secretion suppresses electrogenic Cl secretion Exp Physiol 96 305 316 21169331 1:CAS:528:DC%2BC3MXlsF2rtLY%3D
40. T Hengl H Kaneko K Dauner K Vocke S Frings F Mohrlen 2010 Molecular components of signal amplification in olfactory sensory cilia Proc Natl Acad Sci U S A 107 6052 6057 20231443 1:CAS:528:DC%2BC3cXksF2jsbc%3D
41. D Hicks A Sarkozy N Muelas K Koehler A Huebner G Hudson PF Chinnery R Barresi M Eagle T Polvikoski G Bailey J Miller A Radunovic PJ Hughes R Roberts S Krause MC Walter SH Laval V Straub H Lochmuller K Bushby 2011 A founder mutation in Anoctamin 5 is a major cause of limb-girdle muscular dystrophy Brain 134 171 182 21186264
42. F Huang JR Rock BD Harfe T Cheng X Huang YN Jan LY Jan 2009 Studies on expression and function of the TMEM16A calcium-activated chloride channel Proc Natl Acad Sci U S A 106 21413 21418 19965375 1:CAS:528:DC%2BC3cXjvFGqt7o%3D
43. X Huang TE Godfrey WE Gooding KS McCarty Jr SM Gollin 2006 Comprehensive genome and transcriptome analysis of the 11q13 amplicon in human oral cancer and synteny to the 7F5 amplicon in murine oral carcinoma Genes Chromosomes Cancer 45 1058 1069 16906560 1:CAS:528:DC%2BD28XpvFajsL0%3D (Pubitemid 44435540)
44. SJ Hwang PJ Blair FC Britton KE O'Driscoll G Hennig YR Bayguinov JR Rock BD Harfe KM Sanders SM Ward 2009 Expression of anoctamin 1/TMEM16A by interstitial cells of Cajal is fundamental for slow wave activity in gastrointestinal muscles J Physiol 587 4887 4904 19687122 1:CAS:528: DC%2BD1MXhtlymsbrM
45. J Ji PS Zheng 2010 Activation of mTOR signaling pathway contributes to survival of cervical cancer cells Gynecol Oncol 117 103 108 20102778 1:CAS:528:DC%2BC3cXjs1Wqt7Y%3D
46. E Kalay R Caylan AF Kiroglu T Yasar RW Collin JG Heister J Oostrik CW Cremers HG Brunner A Karaguzel H Kremer 2007 A novel locus for autosomal recessive nonsyndromic hearing impairment, DFNB63, maps to chromosome 11q13.2-q13.4 J Mol Med 85 397 404 17211611 1:CAS:528:DC%2BD2sXjt1Kktbw%3D (Pubitemid 46452256)
47. M Katoh M Katoh 2004 Characterization of human TMEM16G gene in silico Int J Mol Med 14 759 764 15375614 1:CAS:528:DC%2BD2cXovFWmsrk%3D
48. - channel activation in secretory cells Annu Rev Physiol 62 493 513 10845100 1:CAS:528:DC%2BD3cXltlGrsbY%3D (Pubitemid 30618272)
49. K Kunzelmann 2005 Ion channels and cancer J Membr Biol 205 159 173 16362504 1:CAS:528:DC%2BD2MXhtlWrsrjF (Pubitemid 41803693)
50. 29 cells to cAMP, ATP, neurotensin, ionomycin and hypotonic cell swelling Pflügers Arch 428 76 83 7526338 1:CAS:528:DyaK2MXmtlGhug%3D%3D
51. - channels with different functions Cell Calcium 46 233 241 19783045 1:CAS:528: DC%2BD1MXht1yisLjM
52. K Kunzelmann P Kongsuphol K Chootip C Toledo JR Martins J Almaca Y Tian R Witzgall J Ousingsawat R Schreiber 2011 Role of the Ca(2+)-activated Cl(-) channels bestrophin and anoctamin in epithelial cells Biol Chem 392 125 134 21194364 1:CAS:528:DC%2BC3MXkvFCrsbs%3D
53. K Kunzelmann M Mall 2002 Electrolyte transport in the colon: mechanisms and implications for disease Physiol Rev 82 245 289 11773614 1:CAS:528:DC%2BD38XovFSitA%3D%3D (Pubitemid 34654220)
54. - conductance in Xenopus ooyctes Pflügers Arch 434 178 181 (Pubitemid 28068754)
55. K Kunzelmann VM Milenkovic M Spitzner R Barro Soria R Schreiber 2007 Calcium dependent chloride conductance in epithelia: is there a contribution by bestrophin? Pflügers Arch 454 879 889 17361457 1:CAS:528: DC%2BD2sXpslarsrw%3D (Pubitemid 47338454)
56. K Kunzelmann R Schreiber 1999 CFTR, a regulator of channels J Membr Biol 168 1 8 10051684 1:CAS:528:DyaK1MXitVCntLw%3D (Pubitemid 29128256)
57. MR Lalonde ME Kelly S Barnes 2008 Calcium-activated chloride channels in the retina Channels (Austin) 2 252 260
58. N Leblanc J Ledoux S Saleh A Sanguinetti J Angermann KE O'Driscoll F Britton BA Perrino IA Greenwood 2005 Regulation of calcium-activated chloride channels in smooth muscle cells: a complex picture is emerging Can J Physiol Pharmacol 83 541 556 16091780 1:CAS:528:DC%2BD2MXhtFygsLzP (Pubitemid 41603452)
59. RJ Lee JK Foskett 2009 Mechanisms of Ca2+-stimulated fluid secretion by porcine bronchial submucosal gland serous acinar cells Am J Physiol Lung Cell Mol Physiol 298 L210 L231 19965983
60. - channels J Clin Invest 120 1240 1252 20335661 1:CAS:528: DC%2BC3cXksVChsbo%3D
61. M Lorrot M Vasseur 2007 How do the rotavirus NSP4 and bacterial enterotoxins lead differently to diarrhea? Virol J 4 31 17376232
62. U Ludewig M Pusch TJ Jentsch 1996 Two physically distinct pores in the dimeric ClC-0 chloride channel Nature 383 340 343 8848047 1:CAS:528: DyaK28XlvFaitr8%3D (Pubitemid 26321764)
63. I Mahjneh J Jaiswal A Lamminen M Somer G Marlow S Kiuru-Enari R Bashir 2010 A new distal myopathy with mutation in anoctamin 5 Neuromuscul Disord 20 791 795 20692837
64. M Mall M Bleich R Greger M Schürlein J Kühr HH Seydewitz M Brandis K Kunzelmann 1998 Cholinergic ion secretion in human colon requires co-activation by cAMP Am J Physiol 275 G1274 G1281 9843763 1:CAS:528: DyaK1MXhsFKluw%3D%3D
65. B Manoury A Tamuleviciute P Tammaro 2010 TMEM16A/Anoctamin1 protein mediates calcium-activated chloride currents in pulmonary arterial smooth muscle cells J Physiol 588 2305 2314 20421283 1:CAS:528:DC%2BC3cXpt1eqs7c%3D
66. - conductance in cystic fibrosis Acta physiol Scand (abtract) 201S682 P271
67. A Mazzone CE Bernard PR Strege A Beyder LJ Galietta PJ Pasricha JL Rae HP Parkman DR Linden JH Szurszewski T Ordog SJ Gibbons G Farrugia 2011 Altered expression of ANO 1 variants in human diabetic gastroparesis J Biol Chem 286 13393 13403 21349842 1:CAS:528:DC%2BC3MXksVKmtb0%3D
68. JE Melvin D Yule T Shuttleworth T Begenisich 2005 Regulation of fluid and electrolyte secretion in salivary gland acinar cells Annu Rev Physiol 67 445 469 15709965 1:CAS:528:DC%2BD2MXjsFeksrs%3D (Pubitemid 40404496)
69. AJ Mercer K Rabl GE Riccardi NC Brecha SL Stella Jr WB Thoreson 2010 Location of release sites and calcium-activated chloride channels relative to calcium channels at the photoreceptor ribbon synapse J Neurophysiol 105 321 335 21084687
70. DK Meyerholz DA Stoltz E Namati S Ramachandran AA Pezzulo AR Smith MV Rector MJ Suter S Kao G McLennan GJ Tearney J Zabner PB McCray Jr MJ Welsh 2010 Loss of CFTR function produces abnormalities in tracheal development in neonatal pigs and young children Am.J Respir Crit Care Med 182 1251 1261 20622026
71. RE Middleton DJ Pheasant C Miller 1996 Homodimeric architecture of a ClC-type chloride ion channel Nature 383 337 340 8848046 1:CAS:528: DyaK28XlvFaitr4%3D (Pubitemid 26321763)
72. VM Milenkovic M Brockmann H Stohr BH Weber O Strauss 2010 Evolution and functional divergence of the anoctamin family of membrane proteins BMC Evol Biol 10 319 324 20964844
73. K Mizuta S Tsutsumi H Inoue Y Sakamoto K Miyatake K Miyawaki S Noji N Kamata M Itakura 2007 Molecular characterization of GDD1/TMEM16E, the gene product responsible for autosomal dominant gnathodiaphyseal dysplasia Biochem Biophys Res Commun 357 126 132 17418107 1:CAS:528:DC%2BD2sXksFeis7c%3D (Pubitemid 46574508)
74. - influx into intestinal crypts of CF mice Am J Physiol 277 G431 G444 10444458 1:CAS:528:DyaK1MXls1agtrY%3D
75. BD Moyer P Hevezi N Gao M Lu D Kalabat H Soto F Echeverri B Laita SA Yeh M Zoller A Zlotnik 2009 Expression of genes encoding multi-transmembrane proteins in specific primate taste cell populations PLoS ONE 4 e7682 19997627
76. W Namkung PW Phuan AS Verkman 2011 TMEM16A inhibitors reveal TMEM16A as a minor component of CaCC conductance in airway and intestinal epithelial cells J Biol Chem 286 2365 2374 21084298 1:CAS:528:DC%2BC3MXlsFWitQ%3D%3D
77. W Namkung JR Thiagarajah PW Phuan AS Verkman 2010 Inhibition of Ca2+-activated Cl- channels by gallotannins as a possible molecular basis for health benefits of red wine and green tea FASEB J 24 4178 4186 20581223 1:CAS:528:DC%2BC3cXhsVWqu73L
78. B Nilius G Droogmans 2001 Ion channels and their functional role in vascular endothelium Physiol Rev 81 1415 1459 11581493 1:CAS:528: DC%2BD38XislCqsA%3D%3D (Pubitemid 32947776)
79. RE Olver DV Walters M Wilson 2004 Developmental regulation of lung liquid transport Annu Rev Physiol 66 77 101 14977397 1:CAS:528:DC%2BD2cXjt1emsbk%3D (Pubitemid 40614440)
80. T Otowa E Yoshida N Sugaya S Yasuda Y Nishimura K Inoue M Tochigi T Umekage T Miyagawa N Nishida K Tokunaga H Tanii T Sasaki H Kaiya Y Okazaki 2009 Genome-wide association study of panic disorder in the Japanese population J Hum Genet 54 122 126 19165232 1:CAS:528:DC%2BD1MXktFClsbc%3D
81. Ousingsawat J, Martins JR, Kongsuphol P, Schreiber R, Rock JR, Harfe BD, and Kunzelmann K (2009) Defective Ca2+ dependent chloride secretion in TMEM16A -/- pups. 11th International Symposium on Exocrine Secretion, Tokushima, Japan, 23-26 July 2009
82. J Ousingsawat JR Martins R Schreiber JR Rock BD Harfe K Kunzelmann 2009 Loss of TMEM16A causes a defect in epithelial Ca2+ dependent chloride transport J Biol Chem 284 28698 28703 19679661 1:CAS:528:DC%2BD1MXht1Cmt7%2FJ
83. J Ousingsawat Y Tian F AlDehni E Roussa R Schreiber M Mirza DI Cook K Kunzelmann 2011 Rotavirus toxin NSP4 activates the calcium dependent chloride channel TMEM16A and inhibits absorptive Na+ transport Pflügers Arch 461 579 589 21399895 1:CAS:528:DC%2BC3MXktl2ht7o%3D
84. N Pedemonte V Tomati E Sondo LJ Galietta 2010 Influence of cell background on pharmacological rescue of mutant CFTR Am J Physiol Cell Physiol 298 C866 C874 20053923 1:CAS:528:DC%2BC3cXksl2qtLw%3D
85. P Perez-Cornejo J Arreola 2004 Regulation of Ca(2+)-activated chloride channels by cAMP and CFTR in parotid acinar cells Biochem Biophys Res Commun 316 612 617 15033444 1:CAS:528:DC%2BD2cXitFKgsrc%3D (Pubitemid 38367997)
86. S Pifferi M Dibattista A Menini 2009 TMEM16B induces chloride currents activated by calcium in mammalian cells Pflugers Arch 458 1023 1038 19475416 1:CAS:528:DC%2BD1MXhtFensbjN
87. S Pifferi G Pascarella A Boccaccio A Mazzatenta S Gustincich A Menini S Zucchelli 2006 Bestrophin-2 is a candidate calcium-activated chloride channel involved in olfactory transduction Proc Natl Acad Sci U S A 103 12929 12934 16912113 1:CAS:528:DC%2BD28XptVyqt7Y%3D (Pubitemid 44298663)
88. Z Qu HC Hartzell 2000 Anion permeation in Ca(2+)-activated Cl(-) channels J Gen Physiol 116 825 844 11099350 1:CAS:528:DC%2BD3cXovFGnt70%3D
89. S Rasche B Toetter J Adler A Tschapek JF Doerner S Kurtenbach H Hatt H Meyer B Warscheid EM Neuhaus 2010 Tmem16b is specifically expressed in the cilia of olfactory sensory neurons Chem Senses 35 239 245 20100788 1:CAS:528:DC%2BC3cXhslKrt78%3D
90. JR Rock CR Futtner BD Harfe 2008 The transmembrane protein TMEM16A is required for normal development of the murine trachea Dev Biol 321 141 149 18585372 1:CAS:528:DC%2BD1cXhtVSgtLzN
91. JR Rock BD Harfe 2008 Expression of TMEM16 paralogs during murine embryogenesis Dev Dyn 237 2566 2574 18729231 1:CAS:528:DC%2BD1cXhtFylsbvP
92. JR Rock MC Lopez HV Baker BD Harfe 2007 Identification of genes expressed in the mouse limb using a novel ZPA microarray approach Gene Expr Patterns 8 19 26 17911046 1:CAS:528:DC%2BD2sXhtlajsbzE (Pubitemid 350082060)
93. -- secretory channel in mouse airways J Biol Chem 284 14875 14880 19363029 1:CAS:528:DC%2BD1MXmtlChtL0%3D
94. - channel in mouse submandibular salivary gland acinar cells J Biol Chem 285 12990 13001 20177062 1:CAS:528:DC%2BC3cXkvVGis7w%3D
95. LL Runft J Watras LA Jaffe 1999 Calcium release at fertilization of Xenopus eggs requires type I IP(3) receptors, but not SH2 domain-mediated activation of PLCgamma or G(q)-mediated activation of PLCbeta Dev Biol 214 399 411 10525343 1:CAS:528:DyaK1MXms1Crt7k%3D (Pubitemid 29483101)
96. C Sagheddu A Boccaccio M Dibattista G Montani R Tirindelli A Menini 2010 Calcium concentration jumps reveal dynamic ion selectivity of calcium-activated chloride currents in mouse olfactory sensory neurons and TMEM16b-transfected HEK 293T cells J Physiol 588 4189 4204 20837642 1:CAS:528:DC%2BC3cXhsVKlur7O
97. JC Schittny G Miserocchi MP Sparrow 2000 Spontaneous peristaltic airway contractions propel lung liquid through the bronchial tree of intact and fetal lung explants Am J Respir Cell Mol Biol 23 11 18 10873148 1:CAS:528: DC%2BD3cXlt1agsbw%3D (Pubitemid 30597090)
98. R Schneppenheim G Castaman AB Federici W Kreuz R Marschalek J Oldenburg F Oyen U Budde 2007 A common 253-kb deletion involving VWF and TMEM16B in German and Italian patients with severe von Willebrand disease type 3 J Thromb Haemost 5 722 728 17371490 1:CAS:528:DC%2BD2sXltlWgtr4%3D (Pubitemid 46563570)
99. R Schreiber I Uliyakina P Kongsuphol R Warth M Mirza JR Martins K Kunzelmann 2010 Expression and function of epithelial anoctamins J Biol Chem 285 7838 7845 20056604 1:CAS:528:DC%2BC3cXisFaktLo%3D
100. BC Schroeder T Cheng YN Jan LY Jan 2008 Expression cloning of TMEM16A as a calcium-activated chloride channel subunit Cell 134 1019 1029 18805094 1:CAS:528:DC%2BD1cXht1Sns7rP
101. A Schwab 2001 Ion channels and transporters on the move News Physiol Sci 16 29 33 11390943 1:CAS:528:DC%2BD3MXjsV2ntbg%3D 16: 29-33 (Pubitemid 33574454)
102. JT Sheridan EN Worthington K Yu SE Gabriel HC Hartzell R Tarran 2010 Characterization of the oligomeric structure of the Ca2+-activated Cl- channel Ano 1/TMEM16A J Biol Chem 286 1381 1388 21056985
103. M Skals UB Jensen J Ousingsawat K Kunzelmann J Leipziger HA Praetorius 2010 E. coli alpha-hemolysin triggers shrinkage of erythrocytes via KCa3.1 and TMEM16A channels with subsequent phosphatidyl serine exposure J Biol Chem 285 15557 15565 20231275 1:CAS:528:DC%2BC3cXlslSqsbg%3D
104. M Skals NR Jorgensen J Leipziger HA Praetorius 2009 Alpha-hemolysin from Escherichia coli uses endogenous amplification through P2X receptor activation to induce hemolysis Proc Natl Acad Sci U S A 106 4030 4035 19225107 1:CAS:528:DC%2BD1MXjt1eis7c%3D
105. WR Sones AJ Davis N Leblanc IA Greenwood 2010 Cholesterol depletion alters amplitude and pharmacology of vascular calcium-activated chloride channels Cardiovasc Res 87 476 484 20172862 1:CAS:528:DC%2BC3cXptVylu78%3D
106. AB Stephan EY Shum S Hirsh KD Cygnar J Reisert H Zhao 2009 ANO 2 is the cilial calcium-activated chloride channel that may mediate olfactory amplification Proc Natl Acad Sci U S A 106 11776 11781 19561302 1:CAS:528:DC%2BD1MXptVWntbs%3D
107. C Stock A Schwab 2009 Protons make tumor cells move like clockwork Pflugers Arch 458 981 992 19437033 1:CAS:528:DC%2BD1MXptlamsLs%3D
108. H Stohr JB Heisig PM Benz S Schoberl VM Milenkovic O Strauss WM Aartsen J Wijnholds BH Weber HL Schulz 2009 TMEM16B, a novel protein with calcium-dependent chloride channel activity. associates with a presynaptic protein complex in photoreceptor terminals J Neurosci 29 6809 6818 19474308
109. O Strauss 2005 The retinal pigment epithelium in visual function Physiol Rev 85 845 881 15987797 1:CAS:528:DC%2BD2MXmsFymu7Y%3D (Pubitemid 40885218)
110. J Suzuki M Umeda PJ Sims S Nagata 2010 Calcium-dependent phospholipid scrambling by TMEM16F Nature 468 834 838 21107324 1:CAS:528:DC%2BC3cXhsVOrsLjO
111. R Taylor S Roper 1994 Ca(2+)-dependent Cl- conductance in taste cells from Necturus J Neurophysiol 72 475 478 7965031 1:CAS:528:DyaK2cXmtVWhu78%3D
112. F Thevenod 2002 Ion channels in secretory granules of the pancreas and their role in exocytosis and release of secretory proteins Am J Physiol Cell Physiol 283 C651 C672 12176723 1:CAS:528:DC%2BD38XntFOntL4%3D
113. Y Tian P Kongsuphol MJ Hug J Ousingsawat R Witzgall R Schreiber K Kunzelmann 2011 Calmodulin-dependent activation of the epithelial calcium-dependent chloride channel TMEM16A FASEB J 25 1058 1068 21115851 1:CAS:528:DC%2BC3MXivF2ltrg%3D
114. L Tradtrantip W Namkung AS Verkman 2009 Crofelemer, an antisecretory antidiarrheal proanthocyanidin oligomer extracted from Croton lechleri, targets two distinct intestinal chloride channels Mol Pharmacol 77 69 78 19808995
115. S Tsutsumi N Kamata TJ Vokes Y Maruoka K Nakakuki S Enomoto K Omura T Amagasa M Nagayama F Saito-Ohara J Inazawa M Moritani T Yamaoka H Inoue M Itakura 2004 The novel gene encoding a putative transmembrane protein is mutated in gnathodiaphyseal dysplasia (GDD) Am J Hum Genet 74 1255 1261 15124103 1:CAS:528:DC%2BD2cXks1Cqsrk%3D (Pubitemid 38669324)
116. R Vennekens D Trouet A Vankeerberghen T Voets H Cuppens J Eggermont JJ Cassiman G Droogmans B Nilius 1999 Inhibition of volume-regulated anion channels by expression of the cystic fibrosis transmembrane conductance regulator J Physiol Lond 515 75 85 9925879 1:CAS:528:DyaK1MXhsl2lt7o%3D (Pubitemid 29092622)
117. S Vermeer A Hoischen RP Meijer C Gilissen K Neveling N Wieskamp A de Brouwer M Koenig M Anheim M Assoum N Drouot S Todorovic V Milic-Rasic H Lochmuller G Stevanin C Goizet A David A Durr A Brice B Kremer BP van de Warrenburg MM Schijvenaars A Heister M Kwint P Arts J van der Wijst J Veltman EJ Kamsteeg H Scheffer N Knoers 2010 Targeted next-generation sequencing of a 12.5-Mb homozygous region reveals ANO 10 mutations in patients with autosomal-recessive cerebellar ataxia Am J Hum Genet 87 813 819 21092923 1:CAS:528:DC%2BC3cXhsFags7bJ
118. - channels Pflügers Arch 442 280 285 11417226 1:CAS:528:DC%2BD3MXkvFeku74%3D (Pubitemid 32476649)
119. L Wei A Vankeerberghen H Cuppens J Eggermont JJ Cassiman G Droogmans B Nilius 1999 Interaction between calcium-activated chloride channels and the cystic fibrosis transmembrane conductance regulator Pflugers Arch 438 635 641 10555560 1:CAS:528:DyaK1MXns1ylt78%3D (Pubitemid 29454978)
120. RB West CL Corless X Chen BP Rubin S Subramanian K Montgomery S Zhu CA Ball TO Nielsen R Patel JR Goldblum PO Brown MC Heinrich M van de Rijn 2004 The novel marker, DOG1, is expressed ubiquitously in gastrointestinal stromal tumors irrespective of KIT or PDGFRA mutation status Am J Pathol 165 107 113 15215166 1:CAS:528:DC%2BD2cXmtFygsLs%3D (Pubitemid 38821818)
121. YD Yang H Cho JY Koo MH Tak Y Cho WS Shim SP Park J Lee B Lee BM Kim R Raouf YK Shin U Oh 2008 TMEM16A confers receptor-activated calcium-dependent chloride conductance Nature 455 1210 1215 18724360 1:CAS:528:DC%2BD1cXhtlSku7bL
122. O Yermolaieva AS Leonard MK Schnizler FM Abboud MJ Welsh 2004 Extracellular acidosis increases neuronal cell calcium by activating acid-sensing ion channel 1a Proc Natl Acad Sci U S A 101 6752 6757 15082829 1:CAS:528:DC%2BD2cXjvVyhs7s%3D (Pubitemid 38586046)
123. AC Zygmunt WR Gibbons 1992 Properties of the calcium-activated chloride current in heart J Gen Physiol 99 391 414 1375275 1:STN:280:DyaK383mvVyntg%3D%3D