Four basic residues critical for the ion selectivity and pore blocker sensitivity of TMEM16A calcium-activated chloride channels

Proceedings of the National Academy of Sciences of the United States of America

Volumn 112, Issue 11, 2015, Pages 3547-3552

  Peters, Christian J ^a   Yu, Haibo ^b,c   Tien, Jason ^a   Jan, Yuh Nung ^a   Li, Min ^b,d   Jan, Lily Yeh ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c PEKING UNION MEDICAL COLLEGE   (China)

^d GLAXOSMITHKLINE   (United States)

Author keywords

Calcium activated channels; Channel pharmacology; Chloride channels; Ion channel biophysics; TMEM16A

Indexed keywords

ALANINE; ANOCTAMIN 1 PROTEIN; BROMIDE; CALCIUM ACTIVATED CHLORIDE CHANNEL; CHLORIDE; CHLORIDE ION; HALIDE; IODIDE; MEMBRANE PROTEIN; THIOCYANATE; TRANSMEMBRANE PROTEIN 16; UNCLASSIFIED DRUG; AMINO ACID; ANION; CALCIUM; CHLORIDE CHANNEL; MOLECULAR LIBRARY; TMEM16A PROTEIN, MOUSE;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ARTICLE; CALCIUM CELL LEVEL; CHLORIDE TRANSPORT; FEMALE; HUMAN; HUMAN CELL; ION TRANSPORT; PRIORITY JOURNAL; PROTEIN FUNCTION; WHOLE CELL PATCH CLAMP; ANIMAL; CELL MEMBRANE PERMEABILITY; CHANNEL GATING; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECTS; GENETICS; HEK293 CELL LINE; HIGH THROUGHPUT SCREENING; METABOLISM; MOLECULAR LIBRARY; MOUSE; MUTATION; PATCH CLAMP TECHNIQUE; PHARMACOLOGY; STRUCTURE ACTIVITY RELATION;

ALANINE; AMINO ACIDS, BASIC; ANIMALS; ANIONS; CALCIUM; CELL MEMBRANE PERMEABILITY; CHLORIDE CHANNELS; HEK293 CELLS; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; ION CHANNEL GATING; MICE; MODELS, MOLECULAR; MUTATION; PATCH-CLAMP TECHNIQUES; SMALL MOLECULE LIBRARIES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84925321705     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1502291112     Document Type: Article

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