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Volumn 129, Issue 3, 2016, Pages 461-467

Nonsense-mediated mRNA decay in humans at a glance

Author keywords

MRNA surveillance; NMD; RNA quality control; Superfamily 1 ATP dependent RNA helicase; UPF1 protein

Indexed keywords

ADENOSINE TRIPHOSPHATASE; AMINOGLYCOSIDE; AMLEXANOX; ANTISENSE OLIGONUCLEOTIDE; ATALUREN; CARDIAC GLYCOSIDE; INITIATION FACTOR 4A; INITIATION FACTOR 4E; INITIATION FACTOR 4G; LONG UNTRANSLATED RNA; MESSENGER RNA; PROTEIN; RNA HELICASE; UNCLASSIFIED DRUG; UPFRAMESHIFT PROTEIN 1; STOP CODON; TRANSACTIVATOR PROTEIN; UPF1 PROTEIN, HUMAN;

EID: 84957693537     PISSN: 00219533     EISSN: 14779137     Source Type: Journal    
DOI: 10.1242/jcs.181008     Document Type: Article
Times cited : (281)

References (131)
  • 1
    • 0037415691 scopus 로고    scopus 로고
    • SMG-5, required for elegans nonsense-mediated mRNA decay, associates with SMG-2 and protein phosphatase 2A
    • Anders, K. R., Grimson, A. and Anderson, P. (2003). SMG-5, required for C. elegans nonsense-mediated mRNA decay, associates with SMG-2 and protein phosphatase 2A. EMBO J. 22, 641-650.
    • (2003) EMBO J , vol.22 , pp. 641-650
    • Anders, K.R.1    Grimson, A.2    Anderson, P.3
  • 2
    • 78651507958 scopus 로고    scopus 로고
    • The nonsense-mediated mRNA decay SMG-1 kinase is regulated by large-scale conformational changes controlled by SMG-8
    • Arias-Palomo, E., Yamashita, A., Fernández, I. S., Nunez-Ramirez, R., Bamba, Y., Izumi, N., Ohno, S. and Llorca, O. (2011). The nonsense-mediated mRNA decay SMG-1 kinase is regulated by large-scale conformational changes controlled by SMG-8. Genes Dev. 25, 153-164.
    • (2011) Genes Dev , vol.25 , pp. 153-164
    • Arias-Palomo, E.1    Yamashita, A.2    Fernández, I.S.3    Nunez-Ramirez, R.4    Bamba, Y.5    Izumi, N.6    Ohno, S.7    Llorca, O.8
  • 3
    • 0028125262 scopus 로고
    • Mammalian nonsense codons can be cis effectors of nuclear mRNA half-life
    • Belgrader, P., Cheng, J., Zhou, X., Stephenson, L. S. and Maquat, L. E. (1994). Mammalian nonsense codons can be cis effectors of nuclear mRNA half-life. Mol. Cell. Biol. 14, 8219-8228.
    • (1994) Mol. Cell. Biol , vol.14 , pp. 8219-8228
    • Belgrader, P.1    Cheng, J.2    Zhou, X.3    Stephenson, L.S.4    Maquat, L.E.5
  • 4
    • 0033835231 scopus 로고    scopus 로고
    • Characterization of the biochemical properties of the human Upf1 gene product that is involved in nonsense-mediated mRNA decay
    • Bhattacharya, A., Czaplinski, K., Trifillis, P., He, F., Jacobson, A. and Peltz, S. W. (2000). Characterization of the biochemical properties of the human Upf1 gene product that is involved in nonsense-mediated mRNA decay. RNA 6, 1226-1235.
    • (2000) RNA , vol.6 , pp. 1226-1235
    • Bhattacharya, A.1    Czaplinski, K.2    Trifillis, P.3    He, F.4    Jacobson, A.5    Peltz, S.W.6
  • 7
    • 84919843479 scopus 로고    scopus 로고
    • 3' UTR length and messenger ribonucleoprotein composition determine endocleavage efficiencies at termination codons
    • Boehm, V., Haberman, N., Ottens, F., Ule, J. and Gehring, N. H. (2014). 3' UTR length and messenger ribonucleoprotein composition determine endocleavage efficiencies at termination codons. Cell Rep. 9, 555-568.
    • (2014) Cell Rep , vol.9 , pp. 555-568
    • Boehm, V.1    Haberman, N.2    Ottens, F.3    Ule, J.4    Gehring, N.H.5
  • 8
    • 33744994837 scopus 로고    scopus 로고
    • EJCindependent degradation of nonsense immunoglobulin-mu mRNA depends on 3' UTR length
    • Bühler, M., Steiner, S., Mohn, F., Paillusson, A. and Mühlemann, O. (2006). EJCindependent degradation of nonsense immunoglobulin-mu mRNA depends on 3' UTR length. Nat. Struct. Mol. Biol. 13, 462-464.
    • (2006) Nat. Struct. Mol. Biol , vol.13 , pp. 462-464
    • Bühler, M.1    Steiner, S.2    Mohn, F.3    Paillusson, A.4    Mühlemann, O.5
  • 9
    • 0037099302 scopus 로고    scopus 로고
    • A nonsense mutation in the fibrillin-1 gene of a Marfan syndrome patient induces NMD and disrupts an exonic splicing enhancer
    • Caputi, M., Kendzior, R. J. and Beemon, K. L. (2002). A nonsense mutation in the fibrillin-1 gene of a Marfan syndrome patient induces NMD and disrupts an exonic splicing enhancer. Genes Dev. 16, 1754-1759.
    • (2002) Genes Dev , vol.16 , pp. 1754-1759
    • Caputi, M.1    Kendzior, R.J.2    Beemon, K.L.3
  • 11
    • 84906218594 scopus 로고    scopus 로고
    • Phospho-dependent and phospho-independent interactions of the helicase UPF1 with the NMD factors SMG5-SMG7 and SMG6
    • Chakrabarti, S., Bonneau, F., Schussler, S., Eppinger, E. and Conti, E. (2014). Phospho-dependent and phospho-independent interactions of the helicase UPF1 with the NMD factors SMG5-SMG7 and SMG6. Nucleic Acids Res. 42, 9447-9460.
    • (2014) Nucleic Acids Res , vol.42 , pp. 9447-9460
    • Chakrabarti, S.1    Bonneau, F.2    Schussler, S.3    Eppinger, E.4    Conti, E.5
  • 12
    • 37849005006 scopus 로고    scopus 로고
    • NMD factors UPF2 and UPF3 bridge UPF1 to the exon junction complex and stimulate its RNA helicase activity
    • Chamieh, H., Ballut, L., Bonneau, F. and Le Hir, H. (2008). NMD factors UPF2 and UPF3 bridge UPF1 to the exon junction complex and stimulate its RNA helicase activity. Nat. Struct. Mol. Biol. 15, 85-93.
    • (2008) Nat. Struct. Mol. Biol , vol.15 , pp. 85-93
    • Chamieh, H.1    Ballut, L.2    Bonneau, F.3    Le Hir, H.4
  • 16
    • 0027536976 scopus 로고
    • Nonsense codons can reduce the abundance of nuclear mRNA without affecting the abundance of pre-mRNA or the half-life of cytoplasmic mRNA
    • Cheng, J. and Maquat, L. E. (1993). Nonsense codons can reduce the abundance of nuclear mRNA without affecting the abundance of pre-mRNA or the half-life of cytoplasmic mRNA. Mol. Cell. Biol. 13, 1892-1902.
    • (1993) Mol. Cell. Biol , vol.13 , pp. 1892-1902
    • Cheng, J.1    Maquat, L.E.2
  • 17
    • 0041524056 scopus 로고    scopus 로고
    • The apolipoprotein B mRNA editing complex performs a multifunctional cycle and suppresses nonsense-mediated decay
    • Chester, A., Somasekaram, A., Tzimina, M., Jarmuz, A., Gisbourne, J., O'Keefe, R., Scott, J. and Navaratnam, N. (2003). The apolipoprotein B mRNA editing complex performs a multifunctional cycle and suppresses nonsense-mediated decay. EMBO J. 22, 3971-3982.
    • (2003) EMBO J , vol.22 , pp. 3971-3982
    • Chester, A.1    Somasekaram, A.2    Tzimina, M.3    Jarmuz, A.4    Gisbourne, J.5    O'Keefe, R.6    Scott, J.7    Navaratnam, N.8
  • 18
    • 0037279012 scopus 로고    scopus 로고
    • Characterization of human Smg5/7a: a protein with similarities to Caenorhabditis elegans SMG5 and SMG7 that functions in the dephosphorylation of Upf1
    • Chiu, S.-Y., Serin, G., Ohara, O. and Maquat, L. E. (2003). Characterization of human Smg5/7a: a protein with similarities to Caenorhabditis elegans SMG5 and SMG7 that functions in the dephosphorylation of Upf1. RNA 9, 77-87.
    • (2003) RNA , vol.9 , pp. 77-87
    • Chiu, S.-Y.1    Serin, G.2    Ohara, O.3    Maquat, L.E.4
  • 19
    • 58149291462 scopus 로고    scopus 로고
    • Human proline-rich nuclear receptor coregulatory protein 2 mediates an interaction between mRNA surveillance machinery and decapping complex
    • Cho, H., Kim, K. M. and Kim, Y. K. (2009). Human proline-rich nuclear receptor coregulatory protein 2 mediates an interaction between mRNA surveillance machinery and decapping complex. Mol. Cell 33, 75-86.
    • (2009) Mol. Cell , vol.33 , pp. 75-86
    • Cho, H.1    Kim, K.M.2    Kim, Y.K.3
  • 20
    • 84874720941 scopus 로고    scopus 로고
    • SMG5-PNRC2 is functionally dominant compared with SMG5-SMG7 in mammalian nonsense-mediated mRNA decay
    • Cho, H., Han, S., Choe, J., Park, S. G., Choi, S. S. and Kim, Y. K. (2013). SMG5-PNRC2 is functionally dominant compared with SMG5-SMG7 in mammalian nonsense-mediated mRNA decay. Nucleic Acids Res. 41, 1319-1328.
    • (2013) Nucleic Acids Res , vol.41 , pp. 1319-1328
    • Cho, H.1    Han, S.2    Choe, J.3    Park, S.G.4    Choi, S.S.5    Kim, Y.K.6
  • 21
    • 84878888946 scopus 로고    scopus 로고
    • Regulation of axon guidance by compartmentalized nonsense-mediated mRNA decay
    • Colak, D., Ji, S.-J., Porse, B. T. and Jaffrey, S. R. (2013). Regulation of axon guidance by compartmentalized nonsense-mediated mRNA decay. Cell 153, 1252-1265.
    • (2013) Cell , vol.153 , pp. 1252-1265
    • Colak, D.1    Ji, S.-J.2    Porse, B.T.3    Jaffrey, S.R.4
  • 22
    • 27744502876 scopus 로고    scopus 로고
    • Alternative splicing and nonsense-mediated mRNA decay regulate mammalian ribosomal gene expression
    • Cuccurese, M., Russo, G., Russo, A. and Pietropaolo, C. (2005). Alternative splicing and nonsense-mediated mRNA decay regulate mammalian ribosomal gene expression. Nucleic Acids Res. 33, 5965-5977.
    • (2005) Nucleic Acids Res , vol.33 , pp. 5965-5977
    • Cuccurese, M.1    Russo, G.2    Russo, A.3    Pietropaolo, C.4
  • 23
    • 0023871662 scopus 로고
    • Premature translation termination mediates triosephosphate isomerase mRNA degradation
    • Daar, I. O. and Maquat, L. E. (1988). Premature translation termination mediates triosephosphate isomerase mRNA degradation. Mol. Cell. Biol. 8, 802-813.
    • (1988) Mol. Cell. Biol , vol.8 , pp. 802-813
    • Daar, I.O.1    Maquat, L.E.2
  • 24
    • 69949118279 scopus 로고    scopus 로고
    • Inhibition of Nonsense-mediated mRNA decay by the natural product pateamine A through eukaryotic initiation factor 4AIII
    • Dang, Y., Low, W.-K., Xu, J., Gehring, N. H., Dietz, H. C., Romo, D. and Liu, J. O. (2009). Inhibition of Nonsense-mediated mRNA decay by the natural product pateamine A through eukaryotic initiation factor 4AIII. J. Biol. Chem. 284, 23613-23621.
    • (2009) J. Biol. Chem , vol.284 , pp. 23613-23621
    • Dang, Y.1    Low, W.-K.2    Xu, J.3    Gehring, N.H.4    Dietz, H.C.5    Romo, D.6    Liu, J.O.7
  • 26
    • 0037046798 scopus 로고    scopus 로고
    • Translation is required to remove Y14 from mRNAs in the cytoplasm
    • Dostie, J. and Dreyfuss, G. (2002). Translation is required to remove Y14 from mRNAs in the cytoplasm. Curr. Biol. 12, 1060-1067.
    • (2002) Curr. Biol , vol.12 , pp. 1060-1067
    • Dostie, J.1    Dreyfuss, G.2
  • 27
    • 41149111377 scopus 로고    scopus 로고
    • PTC124 is an orally bioavailable compound that promotes suppression of the human CFTR-G542X nonsense allele in a CF mouse model
    • Du, M., Liu, X., Welch, E. M., Hirawat, S., Peltz, S. W. and Bedwell, D. M. (2008). PTC124 is an orally bioavailable compound that promotes suppression of the human CFTR-G542X nonsense allele in a CF mouse model. Proc. Natl. Acad. Sci. USA 105, 2064-2069.
    • (2008) Proc. Natl. Acad. Sci. USA , vol.105 , pp. 2064-2069
    • Du, M.1    Liu, X.2    Welch, E.M.3    Hirawat, S.4    Peltz, S.W.5    Bedwell, D.M.6
  • 29
    • 84878945009 scopus 로고    scopus 로고
    • Nonsense-mediated mRNA decay occurs during eIF4F-dependent translation in human cells
    • Durand, S. and Lykke-Andersen, J. (2013). Nonsense-mediated mRNA decay occurs during eIF4F-dependent translation in human cells. Nat. Struct. Mol. Biol. 20, 702-709.
    • (2013) Nat. Struct. Mol. Biol , vol.20 , pp. 702-709
    • Durand, S.1    Lykke-Andersen, J.2
  • 30
    • 43249093760 scopus 로고    scopus 로고
    • Posttranscriptional gene regulation by spatial rearrangement of the 3' untranslated region
    • Eberle, A. B., Stalder, L., Mathys, H., Orozco, R. Z. and Mühlemann, O. (2008). Posttranscriptional gene regulation by spatial rearrangement of the 3' untranslated region. PLoS Biol. 6, e92.
    • (2008) PLoS Biol , vol.6
    • Eberle, A.B.1    Stalder, L.2    Mathys, H.3    Orozco, R.Z.4    Mühlemann, O.5
  • 32
    • 84907189359 scopus 로고    scopus 로고
    • The interaction of cytoplasmic poly(A)-binding protein with eukaryotic initiation factor 4G suppresses nonsense-mediated mRNA decay
    • Fatscher, T., Boehm, V., Weiche, B. and Gehring, N. H. (2014). The interaction of cytoplasmic poly(A)-binding protein with eukaryotic initiation factor 4G suppresses nonsense-mediated mRNA decay. RNA 20, 1579-1592.
    • (2014) RNA , vol.20 , pp. 1579-1592
    • Fatscher, T.1    Boehm, V.2    Weiche, B.3    Gehring, N.H.4
  • 33
    • 84937968865 scopus 로고    scopus 로고
    • Increase of a group of PTC+ transcripts by curcumin through inhibition of the NMD pathway
    • Feng, D., Su, R.-C., Zou, L., Triggs-Raine, B., Huang, S. and Xie, J. (2015). Increase of a group of PTC+ transcripts by curcumin through inhibition of the NMD pathway. Biochim. Biophys. Acta 1849, 1104-1115.
    • (2015) Biochim. Biophys. Acta , vol.1849 , pp. 1104-1115
    • Feng, D.1    Su, R.-C.2    Zou, L.3    Triggs-Raine, B.4    Huang, S.5    Xie, J.6
  • 35
    • 84876362947 scopus 로고    scopus 로고
    • Tight intramolecular regulation of the human Upf1 helicase by its N-and C-terminal domains
    • Fiorini, F., Boudvillain, M. and Le Hir, H. (2013). Tight intramolecular regulation of the human Upf1 helicase by its N-and C-terminal domains. Nucleic Acids Res. 41, 2404-2415.
    • (2013) Nucleic Acids Res , vol.41 , pp. 2404-2415
    • Fiorini, F.1    Boudvillain, M.2    Le Hir, H.3
  • 36
    • 84936805108 scopus 로고    scopus 로고
    • Human Upf1 is a highly processive RNA helicase and translocase with RNP remodelling activities
    • Fiorini, F., Bagchi, D., Le Hir, H. and Croquette, V. (2015). Human Upf1 is a highly processive RNA helicase and translocase with RNP remodelling activities. Nat. Commun. 6, 7581.
    • (2015) Nat. Commun , vol.6 , pp. 7581
    • Fiorini, F.1    Bagchi, D.2    Le Hir, H.3    Croquette, V.4
  • 37
    • 78649949096 scopus 로고    scopus 로고
    • Upf1 ATPase-dependent mRNP disassembly is required for completion of nonsense-mediated mRNA decay
    • Franks, T. M., Singh, G. and Lykke-Andersen, J. (2010). Upf1 ATPase-dependent mRNP disassembly is required for completion of nonsense-mediated mRNA decay. Cell 143, 938-950.
    • (2010) Cell , vol.143 , pp. 938-950
    • Franks, T.M.1    Singh, G.2    Lykke-Andersen, J.3
  • 38
    • 0032837376 scopus 로고    scopus 로고
    • Nonsense-mediated mRNA decay in health and disease
    • Frischmeyer, P. A. and Dietz, H. C. (1999). Nonsense-mediated mRNA decay in health and disease. Hum. Mol. Genet. 8, 1893-1900.
    • (1999) Hum. Mol. Genet , vol.8 , pp. 1893-1900
    • Frischmeyer, P.A.1    Dietz, H.C.2
  • 39
    • 15444373402 scopus 로고    scopus 로고
    • Cap-binding protein 1-mediated and eukaryotic translation initiation factor 4E-mediated pioneer rounds of translation in yeast
    • Gao, Q., Das, B., Sherman, F. and Maquat, L. E. (2005). Cap-binding protein 1-mediated and eukaryotic translation initiation factor 4E-mediated pioneer rounds of translation in yeast. Proc. Natl. Acad. Sci. USA 102, 4258-4263.
    • (2005) Proc. Natl. Acad. Sci. USA , vol.102 , pp. 4258-4263
    • Gao, Q.1    Das, B.2    Sherman, F.3    Maquat, L.E.4
  • 40
    • 2942595765 scopus 로고    scopus 로고
    • Nonsense-mediated messenger RNA decay is initiated by endonucleolytic cleavage in Drosophila
    • Gatfield, D. and Izaurralde, E. (2004). Nonsense-mediated messenger RNA decay is initiated by endonucleolytic cleavage in Drosophila. Nature 429, 575-578.
    • (2004) Nature , vol.429 , pp. 575-578
    • Gatfield, D.1    Izaurralde, E.2
  • 42
    • 25844512736 scopus 로고    scopus 로고
    • Exon-junction complex components specify distinct routes of nonsense-mediated mRNA decay with differential cofactor requirements
    • Gehring, N. H., Kunz, J. B., Neu-Yilik, G., Breit, S., Viegas, M. H., Hentze, M. W. and Kulozik, A. E. (2005). Exon-junction complex components specify distinct routes of nonsense-mediated mRNA decay with differential cofactor requirements. Mol. Cell 20, 65-75.
    • (2005) Mol. Cell , vol.20 , pp. 65-75
    • Gehring, N.H.1    Kunz, J.B.2    Neu-Yilik, G.3    Breit, S.4    Viegas, M.H.5    Hentze, M.W.6    Kulozik, A.E.7
  • 43
    • 65249119729 scopus 로고    scopus 로고
    • Disassembly of exon junction complexes by PYM
    • Gehring, N. H., Lamprinaki, S., Kulozik, A. E. and Hentze, M. W. (2009). Disassembly of exon junction complexes by PYM. Cell 137, 536-548.
    • (2009) Cell , vol.137 , pp. 536-548
    • Gehring, N.H.1    Lamprinaki, S.2    Kulozik, A.E.3    Hentze, M.W.4
  • 47
    • 77958459763 scopus 로고    scopus 로고
    • Upf1 senses 3'UTR length to potentiate mRNA decay
    • Hogg, J. R. and Goff, S. P. (2010). Upf1 senses 3'UTR length to potentiate mRNA decay. Cell 143, 379-389.
    • (2010) Cell , vol.143 , pp. 379-389
    • Hogg, J.R.1    Goff, S.P.2
  • 49
    • 27144478105 scopus 로고    scopus 로고
    • CBP80 promotes interaction of Upf1 with Upf2 during nonsense-mediated mRNA decay in mammalian cells
    • Hosoda, N., Kim, Y. K., Lejeune, F. and Maquat, L. E. (2005). CBP80 promotes interaction of Upf1 with Upf2 during nonsense-mediated mRNA decay in mammalian cells. Nat. Struct. Mol. Biol. 12, 893-901.
    • (2005) Nat. Struct. Mol. Biol , vol.12 , pp. 893-901
    • Hosoda, N.1    Kim, Y.K.2    Lejeune, F.3    Maquat, L.E.4
  • 51
    • 0021288116 scopus 로고
    • 0-Thalassemia gene: a premature termination codon caused β-mRNA deficiency without affecting cytoplasmic β-mRNA stability
    • 0-Thalassemia gene: a premature termination codon caused β-mRNA deficiency without affecting cytoplasmic β-mRNA stability. Blood 64, 23-32.
    • (1984) Blood , vol.64 , pp. 23-32
    • Humphries, R.K.1    Ley, T.J.2    Anagnou, N.P.3    Baur, A.W.4    Nienhuis, A.W.5
  • 52
    • 57049126216 scopus 로고    scopus 로고
    • SMG6 is the catalytic endonuclease that cleaves mRNAs containing nonsense codons in metazoan
    • Huntzinger, E., Kashima, I., Fauser, M., Saulière, J. and Izaurralde, E. (2008). SMG6 is the catalytic endonuclease that cleaves mRNAs containing nonsense codons in metazoan. RNA 14, 2609-2617.
    • (2008) RNA , vol.14 , pp. 2609-2617
    • Huntzinger, E.1    Kashima, I.2    Fauser, M.3    Saulière, J.4    Izaurralde, E.5
  • 53
    • 84885069820 scopus 로고    scopus 로고
    • Global analyses of UPF1 binding and function reveal expanded scope of nonsense-mediated mRNA decay
    • Hurt, J. A., Robertson, A. D. and Burge, C. B. (2013). Global analyses of UPF1 binding and function reveal expanded scope of nonsense-mediated mRNA decay. Genome Res. 23, 1636-1650.
    • (2013) Genome Res , vol.23 , pp. 1636-1650
    • Hurt, J.A.1    Robertson, A.D.2    Burge, C.B.3
  • 54
    • 77955339642 scopus 로고    scopus 로고
    • UPF1 association with the cap-binding protein, CBP80, promotes nonsense-mediated mRNA decay at two distinct steps
    • Hwang, J., Sato, H., Tang, Y., Matsuda, D. and Maquat, L. E. (2010). UPF1 association with the cap-binding protein, CBP80, promotes nonsense-mediated mRNA decay at two distinct steps. Mol. Cell 39, 396-409.
    • (2010) Mol. Cell , vol.39 , pp. 396-409
    • Hwang, J.1    Sato, H.2    Tang, Y.3    Matsuda, D.4    Maquat, L.E.5
  • 55
    • 0035823036 scopus 로고    scopus 로고
    • Evidence for a pioneer round of mRNA translation: mRNAs subject to nonsense-mediated decay in mammalian cells are bound by CBP80 and CBP20
    • Ishigaki, Y., Li, X., Serin, G. and Maquat, L. E. (2001). Evidence for a pioneer round of mRNA translation: mRNAs subject to nonsense-mediated decay in mammalian cells are bound by CBP80 and CBP20. Cell 106, 607-617.
    • (2001) Cell , vol.106 , pp. 607-617
    • Ishigaki, Y.1    Li, X.2    Serin, G.3    Maquat, L.E.4
  • 56
    • 41949113083 scopus 로고    scopus 로고
    • Upf1 phosphorylation triggers translational repression during nonsense-mediated mRNA decay
    • Isken, O., Kim, Y. K., Hosoda, N., Mayeur, G. L., Hershey, J. W. B. and Maquat, L. E. (2008). Upf1 phosphorylation triggers translational repression during nonsense-mediated mRNA decay. Cell 133, 314-327.
    • (2008) Cell , vol.133 , pp. 314-327
    • Isken, O.1    Kim, Y.K.2    Hosoda, N.3    Mayeur, G.L.4    Hershey, J.W.B.5    Maquat, L.E.6
  • 57
    • 40949148553 scopus 로고    scopus 로고
    • Interactions between UPF1, eRFs, PABP and the exon junction complex suggest an integrated model for mammalian NMD pathways
    • Ivanov, P. V., Gehring, N. H., Kunz, J. B., Hentze, M.W. and Kulozik, A. E. (2008). Interactions between UPF1, eRFs, PABP and the exon junction complex suggest an integrated model for mammalian NMD pathways. EMBO J. 27, 736-747.
    • (2008) EMBO J , vol.27 , pp. 736-747
    • Ivanov, P.V.1    Gehring, N.H.2    Kunz, J.B.3    Hentze, M.W.4    Kulozik, A.E.5
  • 58
    • 84887562180 scopus 로고    scopus 로고
    • The UPF3B gene, implicated in intellectual disability, autism, ADHD and childhood onset schizophrenia regulates neural progenitor cell behaviour and neuronal outgrowth
    • Jolly, L. A., Homan, C. C., Jacob, R., Barry, S. and Gecz, J. (2013). The UPF3B gene, implicated in intellectual disability, autism, ADHD and childhood onset schizophrenia regulates neural progenitor cell behaviour and neuronal outgrowth. Hum. Mol. Genet. 22, 4673-4687.
    • (2013) Hum. Mol. Genet , vol.22 , pp. 4673-4687
    • Jolly, L.A.1    Homan, C.C.2    Jacob, R.3    Barry, S.4    Gecz, J.5
  • 59
    • 84873026843 scopus 로고    scopus 로고
    • An unusual arrangement of two 14-3-3-like domains in the SMG5-SMG7 heterodimer is required for efficient nonsense-mediated mRNA decay
    • Jonas, S., Weichenrieder, O. and Izaurralde, E. (2013). An unusual arrangement of two 14-3-3-like domains in the SMG5-SMG7 heterodimer is required for efficient nonsense-mediated mRNA decay. Genes Dev. 27, 211-225.
    • (2013) Genes Dev , vol.27 , pp. 211-225
    • Jonas, S.1    Weichenrieder, O.2    Izaurralde, E.3
  • 60
    • 84929054432 scopus 로고    scopus 로고
    • Eukaryotic initiation factor 4G suppresses nonsense-mediated mRNA decay by two genetically separable mechanisms
    • Joncourt, R., Eberle, A. B., Rufener, S. C. and Mühlemann, O. (2014). Eukaryotic initiation factor 4G suppresses nonsense-mediated mRNA decay by two genetically separable mechanisms. PLoS ONE 9, e104391.
    • (2014) PLoS ONE , vol.9
    • Joncourt, R.1    Eberle, A.B.2    Rufener, S.C.3    Mühlemann, O.4
  • 61
    • 79959284255 scopus 로고    scopus 로고
    • Converting nonsense codons into sense codons by targeted pseudouridylation
    • Karijolich, J. and Yu, Y.-T. (2011). Converting nonsense codons into sense codons by targeted pseudouridylation. Nature 474, 395-398.
    • (2011) Nature , vol.474 , pp. 395-398
    • Karijolich, J.1    Yu, Y.-T.2
  • 62
    • 32044435368 scopus 로고    scopus 로고
    • Binding of a novel SMG-1-Upf1-eRF1-eRF3 complex (SURF) to the exon junction complex triggers Upf1 phosphorylation and nonsense-mediated mRNA decay
    • Kashima, I., Yamashita, A., Izumi, N., Kataoka, N., Morishita, R., Hoshino, S., Ohno, M., Dreyfuss, G. and Ohno, S. (2006). Binding of a novel SMG-1-Upf1-eRF1-eRF3 complex (SURF) to the exon junction complex triggers Upf1 phosphorylation and nonsense-mediated mRNA decay. Genes Dev. 20, 355-367.
    • (2006) Genes Dev , vol.20 , pp. 355-367
    • Kashima, I.1    Yamashita, A.2    Izumi, N.3    Kataoka, N.4    Morishita, R.5    Hoshino, S.6    Ohno, M.7    Dreyfuss, G.8    Ohno, S.9
  • 63
    • 0035823150 scopus 로고    scopus 로고
    • Role of the nonsense-mediated decay factor hUpf3 in the splicing-dependent exon-exon junction complex
    • Kim, V. N., Kataoka, N. and Dreyfuss, G. (2001). Role of the nonsense-mediated decay factor hUpf3 in the splicing-dependent exon-exon junction complex. Science 293, 1832-1836.
    • (2001) Science , vol.293 , pp. 1832-1836
    • Kim, V.N.1    Kataoka, N.2    Dreyfuss, G.3
  • 64
    • 33646865949 scopus 로고    scopus 로고
    • Functions of hUpf3a and hUpf3b in nonsense-mediated mRNA decay and translation
    • Kunz, J. B., Neu-Yilik, G., Hentze, M. W., Kulozik, A. E. and Gehring, N. H. (2006). Functions of hUpf3a and hUpf3b in nonsense-mediated mRNA decay and translation. RNA 12, 1015-1022.
    • (2006) RNA , vol.12 , pp. 1015-1022
    • Kunz, J.B.1    Neu-Yilik, G.2    Hentze, M.W.3    Kulozik, A.E.4    Gehring, N.H.5
  • 65
    • 84874504687 scopus 로고    scopus 로고
    • Rules that govern UPF1 binding to mRNA 3' UTRs
    • Kurosaki, T. and Maquat, L. E. (2013). Rules that govern UPF1 binding to mRNA 3' UTRs. Proc. Natl. Acad. Sci. USA 110, 3357-3362.
    • (2013) Proc. Natl. Acad. Sci. USA , vol.110 , pp. 3357-3362
    • Kurosaki, T.1    Maquat, L.E.2
  • 66
    • 84906885914 scopus 로고    scopus 로고
    • A post-translational regulatory switch on UPF1 controls targeted mRNA degradation
    • Kurosaki, T., Li, W., Hoque, M., Popp, M. W.-L., Ermolenko, D. N., Tian, B. and Maquat, L. E. (2014). A post-translational regulatory switch on UPF1 controls targeted mRNA degradation. Genes Dev. 28, 1900-1916.
    • (2014) Genes Dev , vol.28 , pp. 1900-1916
    • Kurosaki, T.1    Li, W.2    Hoque, M.3    Popp, M.W.-L.4    Ermolenko, D.N.5    Tian, B.6    Maquat, L.E.7
  • 67
    • 84988288865 scopus 로고    scopus 로고
    • Regulation of splicing factors by alternative splicing and NMD is conserved between kingdoms yet evolutionarily flexible
    • Lareau, L. F. and Brenner, S. E. (2015). Regulation of splicing factors by alternative splicing and NMD is conserved between kingdoms yet evolutionarily flexible. Mol. Biol. Evol. 32, 1072-1079.
    • (2015) Mol. Biol. Evol , vol.32 , pp. 1072-1079
    • Lareau, L.F.1    Brenner, S.E.2
  • 68
    • 77953914253 scopus 로고    scopus 로고
    • Mutations of the UPF3B gene, which encodes a protein widely expressed in neurons, are associated with nonspecific mental retardation with or without autism
    • Laumonnier, F., Shoubridge, C., Antar, C., Nguyen, L. S., Van Esch, H., Kleefstra, T., Briault, S., Fryns, J. P., Hamel, B., Chelly, J. et al. (2010). Mutations of the UPF3B gene, which encodes a protein widely expressed in neurons, are associated with nonspecific mental retardation with or without autism. Mol. Psychiatry 15, 767-776.
    • (2010) Mol. Psychiatry , vol.15 , pp. 767-776
    • Laumonnier, F.1    Shoubridge, C.2    Antar, C.3    Nguyen, L.S.4    Van Esch, H.5    Kleefstra, T.6    Briault, S.7    Fryns, J.P.8    Hamel, B.9    Chelly, J.10
  • 69
    • 0034672093 scopus 로고    scopus 로고
    • The spliceosome deposits multiple proteins 20-24 nucleotides upstream of mRNA exon-exon junctions
    • Le Hir, H., Izaurralde, E., Maquat, L. E. and Moore, M. J. (2000a). The spliceosome deposits multiple proteins 20-24 nucleotides upstream of mRNA exon-exon junctions. EMBO J. 19, 6860-6869.
    • (2000) EMBO J , vol.19 , pp. 6860-6869
    • Le Hir, H.1    Izaurralde, E.2    Maquat, L.E.3    Moore, M.J.4
  • 70
    • 0034193569 scopus 로고    scopus 로고
    • Pre-mRNA splicing alters mRNP composition: evidence for stable association of proteins at exon-exon junctions
    • Le Hir, H., Moore, M. J. and Maquat, L. E. (2000b). Pre-mRNA splicing alters mRNP composition: evidence for stable association of proteins at exon-exon junctions. Genes Dev. 14, 1098-1108.
    • (2000) Genes Dev , vol.14 , pp. 1098-1108
    • Le Hir, H.1    Moore, M.J.2    Maquat, L.E.3
  • 71
    • 0035801373 scopus 로고    scopus 로고
    • The exon-exon junction complex provides a binding platform for factors involved in mRNA export and nonsense-mediated mRNA decay
    • Le Hir, H., Gatfield, D., Izaurralde, E. and Moore, M. J. (2001). The exon-exon junction complex provides a binding platform for factors involved in mRNA export and nonsense-mediated mRNA decay. EMBO J. 20, 4987-4997.
    • (2001) EMBO J , vol.20 , pp. 4987-4997
    • Le Hir, H.1    Gatfield, D.2    Izaurralde, E.3    Moore, M.J.4
  • 72
    • 84867328079 scopus 로고    scopus 로고
    • Pharmaceutical therapies to recode nonsense mutations in inherited diseases
    • Lee, H.-L. R. and Dougherty, J. P. (2012). Pharmaceutical therapies to recode nonsense mutations in inherited diseases. Pharmacol. Ther. 136, 227-266.
    • (2012) Pharmacol. Ther , vol.136 , pp. 227-266
    • Lee, H.-L.R.1    Dougherty, J.P.2
  • 73
    • 84938585895 scopus 로고    scopus 로고
    • Target Discrimination in nonsense-mediated mRNA decay requires Upf1 ATPase activity
    • Lee, S. R., Pratt, G. A., Martinez, F. J., Yeo, G.W. and Lykke-Andersen, J. (2015). Target Discrimination in nonsense-mediated mRNA decay requires Upf1 ATPase activity. Mol. Cell 59, 413-425.
    • (2015) Mol. Cell , vol.59 , pp. 413-425
    • Lee, S.R.1    Pratt, G.A.2    Martinez, F.J.3    Yeo, G.W.4    Lykke-Andersen, J.5
  • 74
    • 0025786141 scopus 로고
    • The product of the yeast UPF1 gene is required for rapid turnover of mRNAs containing a premature translational termination codon
    • Leeds, P., Peltz, S.W., Jacobson, A. and Culbertson, M. R. (1991). The product of the yeast UPF1 gene is required for rapid turnover of mRNAs containing a premature translational termination codon. Genes Dev. 5, 2303-2314.
    • (1991) Genes Dev , vol.5 , pp. 2303-2314
    • Leeds, P.1    Peltz, S.W.2    Jacobson, A.3    Culbertson, M.R.4
  • 75
    • 0036645697 scopus 로고    scopus 로고
    • The exon junction complex is detected on CBP80-bound but not eIF4E-bound mRNA in mammalian cells: dynamics of mRNP remodeling
    • Lejeune, F., Ishigaki, Y., Li, X. and Maquat, L. E. (2002). The exon junction complex is detected on CBP80-bound but not eIF4E-bound mRNA in mammalian cells: dynamics of mRNP remodeling. EMBO J. 21, 3536-3545.
    • (2002) EMBO J , vol.21 , pp. 3536-3545
    • Lejeune, F.1    Ishigaki, Y.2    Li, X.3    Maquat, L.E.4
  • 76
    • 4744347153 scopus 로고    scopus 로고
    • eIF4G is required for the pioneer round of translation in mammalian cells
    • Lejeune, F., Ranganathan, A. C. and Maquat, L. E. (2004). eIF4G is required for the pioneer round of translation in mammalian cells. Nat. Struct. Mol. Biol. 11, 992-1000.
    • (2004) Nat. Struct. Mol. Biol , vol.11 , pp. 992-1000
    • Lejeune, F.1    Ranganathan, A.C.2    Maquat, L.E.3
  • 77
    • 0037422575 scopus 로고    scopus 로고
    • Evidence for the widespread coupling of alternative splicing and nonsense-mediated mRNA decay in humans
    • Lewis, B. P., Green, R. E. and Brenner, S. E. (2003). Evidence for the widespread coupling of alternative splicing and nonsense-mediated mRNA decay in humans. Proc. Natl. Acad. Sci. USA 100, 189-192.
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , pp. 189-192
    • Lewis, B.P.1    Green, R.E.2    Brenner, S.E.3
  • 78
    • 54849413018 scopus 로고    scopus 로고
    • Introducing sense into nonsense in treatments of human genetic diseases
    • Linde, L. and Kerem, B. (2008). Introducing sense into nonsense in treatments of human genetic diseases. Trends Genet. 24, 552-563.
    • (2008) Trends Genet , vol.24 , pp. 552-563
    • Linde, L.1    Kerem, B.2
  • 79
    • 84885356907 scopus 로고    scopus 로고
    • The SMG5-SMG7 heterodimer directly recruits the CCR4-NOT deadenylase complex to mRNAs containing nonsense codons via interaction with POP2
    • Loh, B., Jonas, S. and Izaurralde, E. (2013). The SMG5-SMG7 heterodimer directly recruits the CCR4-NOT deadenylase complex to mRNAs containing nonsense codons via interaction with POP2. Genes Dev. 27, 2125-2138.
    • (2013) Genes Dev , vol.27 , pp. 2125-2138
    • Loh, B.1    Jonas, S.2    Izaurralde, E.3
  • 80
    • 84896723059 scopus 로고    scopus 로고
    • Posttranscriptional control of the stem cell and neurogenic programs by the nonsense-mediated RNA decay pathway
    • Lou, C. H., Shao, A., Shum, E. Y., Espinoza, J. L., Huang, L., Karam, R. and Wilkinson, M. F. (2014). Posttranscriptional control of the stem cell and neurogenic programs by the nonsense-mediated RNA decay pathway. Cell Rep. 6, 748-764.
    • (2014) Cell Rep , vol.6 , pp. 748-764
    • Lou, C.H.1    Shao, A.2    Shum, E.Y.3    Espinoza, J.L.4    Huang, L.5    Karam, R.6    Wilkinson, M.F.7
  • 81
    • 0034704201 scopus 로고    scopus 로고
    • Human Upf proteins target an mRNA for nonsense-mediated decay when bound downstream of a termination codon
    • Lykke-Andersen, J., Shu, M.-D. and Steitz, J. A. (2000). Human Upf proteins target an mRNA for nonsense-mediated decay when bound downstream of a termination codon. Cell 103, 1121-1131.
    • (2000) Cell , vol.103 , pp. 1121-1131
    • Lykke-Andersen, J.1    Shu, M.-D.2    Steitz, J.A.3
  • 82
    • 0035823247 scopus 로고    scopus 로고
    • Communication of the position of exon-exon junctions to the mRNA surveillance machinery by the protein RNPS1
    • Lykke-Andersen, J., Shu, M.-D. and Steitz, J. A. (2001). Communication of the position of exon-exon junctions to the mRNA surveillance machinery by the protein RNPS1. Science 293, 1836-1839.
    • (2001) Science , vol.293 , pp. 1836-1839
    • Lykke-Andersen, J.1    Shu, M.-D.2    Steitz, J.A.3
  • 83
    • 84910640414 scopus 로고    scopus 로고
    • Human nonsense-mediated RNA decay initiates widely by endonucleolysis and targets snoRNA host genes
    • Lykke-Andersen, S., Chen, Y., Ardal, B. R., Lilje, B., Waage, J., Sandelin, A. and Jensen, T. H. (2014). Human nonsense-mediated RNA decay initiates widely by endonucleolysis and targets snoRNA host genes. Genes Dev. 28, 2498-2517.
    • (2014) Genes Dev , vol.28 , pp. 2498-2517
    • Lykke-Andersen, S.1    Chen, Y.2    Ardal, B.R.3    Lilje, B.4    Waage, J.5    Sandelin, A.6    Jensen, T.H.7
  • 84
    • 84929171496 scopus 로고    scopus 로고
    • Quality control of transcription start site selection by nonsense-mediated-mRNA decay
    • Malabat, C., Feuerbach, F., Ma, L., Saveanu, C. and Jacquier, A. (2015). Quality control of transcription start site selection by nonsense-mediated-mRNA decay. eLife 4, e06722.
    • (2015) eLife , vol.4
    • Malabat, C.1    Feuerbach, F.2    Ma, L.3    Saveanu, C.4    Jacquier, A.5
  • 86
    • 84902125654 scopus 로고    scopus 로고
    • Identification and characterization of small molecules that inhibit nonsense-mediated RNA decay and suppress nonsense p53 mutations
    • Martin, L., Grigoryan, A., Wang, D., Wang, J., Breda, L., Rivella, S., Cardozo, T. and Gardner, L. B. (2014). Identification and characterization of small molecules that inhibit nonsense-mediated RNA decay and suppress nonsense p53 mutations. Cancer Res. 74, 3104-3113.
    • (2014) Cancer Res , vol.74 , pp. 3104-3113
    • Martin, L.1    Grigoryan, A.2    Wang, D.3    Wang, J.4    Breda, L.5    Rivella, S.6    Cardozo, T.7    Gardner, L.B.8
  • 87
    • 34948854852 scopus 로고    scopus 로고
    • Failsafe nonsensemediated mRNA decay does not detectably target eIF4E-bound mRNA
    • Matsuda, D., Hosoda, N., Kim, Y. K. and Maquat, L. E. (2007). Failsafe nonsensemediated mRNA decay does not detectably target eIF4E-bound mRNA. Nat. Struct. Mol. Biol. 14, 974-979.
    • (2007) Nat. Struct. Mol. Biol , vol.14 , pp. 974-979
    • Matsuda, D.1    Hosoda, N.2    Kim, Y.K.3    Maquat, L.E.4
  • 88
    • 84905705220 scopus 로고    scopus 로고
    • Structures of SMG1-UPFs complexes: SMG1 contributes to regulate UPF2-dependent activation of UPF1 in NMD
    • Melero, R., Uchiyama, A., Castaño, R., Kataoka, N., Kurosawa, H., Ohno, S., Yamashita, A. and Llorca, O. (2014). Structures of SMG1-UPFs complexes: SMG1 contributes to regulate UPF2-dependent activation of UPF1 in NMD. Structure 22, 1105-1119.
    • (2014) Structure , vol.22 , pp. 1105-1119
    • Melero, R.1    Uchiyama, A.2    Castaño, R.3    Kataoka, N.4    Kurosawa, H.5    Ohno, S.6    Yamashita, A.7    Llorca, O.8
  • 89
    • 0034460323 scopus 로고    scopus 로고
    • Novel Upf2p orthologues suggest a functional link between translation initiation and nonsense surveillance complexes
    • Mendell, J. T., Medghalchi, S. M., Lake, R. G., Noensie, E. N. and Dietz, H. C. (2000). Novel Upf2p orthologues suggest a functional link between translation initiation and nonsense surveillance complexes. Mol. Cell. Biol. 20, 8944-8957.
    • (2000) Mol. Cell. Biol , vol.20 , pp. 8944-8957
    • Mendell, J.T.1    Medghalchi, S.M.2    Lake, R.G.3    Noensie, E.N.4    Dietz, H.C.5
  • 90
    • 6944256813 scopus 로고    scopus 로고
    • Nonsense surveillance regulates expression of diverse classes of mammalian transcripts and mutes genomic noise
    • Mendell, J. T., Sharifi, N. A., Meyers, J. L., Martinez-Murillo, F. and Dietz, H. C. (2004). Nonsense surveillance regulates expression of diverse classes of mammalian transcripts and mutes genomic noise. Nat. Genet. 36, 1073-1078.
    • (2004) Nat. Genet , vol.36 , pp. 1073-1078
    • Mendell, J.T.1    Sharifi, N.A.2    Meyers, J.L.3    Martinez-Murillo, F.4    Dietz, H.C.5
  • 91
    • 0031436408 scopus 로고    scopus 로고
    • The presence of an intron within the rat gene for selenium-dependent glutathione peroxidase 1 is not required to protect nuclear RNA from UGA-mediated decay
    • Moriarty, P. M., Reddy, C. C. and Maquat, L. E. (1997). The presence of an intron within the rat gene for selenium-dependent glutathione peroxidase 1 is not required to protect nuclear RNA from UGA-mediated decay. RNA 3, 1369-1373.
    • (1997) RNA , vol.3 , pp. 1369-1373
    • Moriarty, P.M.1    Reddy, C.C.2    Maquat, L.E.3
  • 92
    • 0031896755 scopus 로고    scopus 로고
    • Selenium deficiency reduces the abundance of mRNA for Se-dependent glutathione peroxidase 1 by a UGA-dependent mechanism likely to be nonsense codon-mediated decay of cytoplasmic mRNA
    • Moriarty, P. M., Reddy, C. C. and Maquat, L. E. (1998). Selenium deficiency reduces the abundance of mRNA for Se-dependent glutathione peroxidase 1 by a UGA-dependent mechanism likely to be nonsense codon-mediated decay of cytoplasmic mRNA. Mol. Cell. Biol. 18, 2932-2939.
    • (1998) Mol. Cell. Biol , vol.18 , pp. 2932-2939
    • Moriarty, P.M.1    Reddy, C.C.2    Maquat, L.E.3
  • 93
    • 49149098054 scopus 로고    scopus 로고
    • A metaanalysis of nonsense mutations causing human genetic disease
    • Mort, M., Ivanov, D., Cooper, D. N. and Chuzhanova, N. A. (2008). A metaanalysis of nonsense mutations causing human genetic disease. Hum. Mutat. 29, 1037-1047.
    • (2008) Hum. Mutat , vol.29 , pp. 1037-1047
    • Mort, M.1    Ivanov, D.2    Cooper, D.N.3    Chuzhanova, N.A.4
  • 94
    • 0032104190 scopus 로고    scopus 로고
    • A rule for termination-codon position within intron-containing genes: when nonsense affects RNA abundance
    • Nagy, E. and Maquat, L. E. (1998). A rule for termination-codon position within intron-containing genes: when nonsense affects RNA abundance. Trends Biochem. Sci. 23, 198-199.
    • (1998) Trends Biochem. Sci , vol.23 , pp. 198-199
    • Nagy, E.1    Maquat, L.E.2
  • 95
    • 84857486516 scopus 로고    scopus 로고
    • Functional characterization and targeted correction of ATM mutations identified in Japanese patients with ataxiatelangiectasia
    • Nakamura, K., Du, L., Tunuguntla, R., Fike, F., Cavalieri, S., Morio, T., Mizutani, S., Brusco, A. and Gatti, R. A. (2012). Functional characterization and targeted correction of ATM mutations identified in Japanese patients with ataxiatelangiectasia. Hum. Mutat. 33, 198-208.
    • (2012) Hum. Mutat , vol.33 , pp. 198-208
    • Nakamura, K.1    Du, L.2    Tunuguntla, R.3    Fike, F.4    Cavalieri, S.5    Morio, T.6    Mizutani, S.7    Brusco, A.8    Gatti, R.A.9
  • 98
    • 84906239869 scopus 로고    scopus 로고
    • A novel phosphorylation-independent interaction between SMG6 and UPF1 is essential for human NMD
    • Nicholson, P., Josi, C., Kurosawa, H., Yamashita, A. and Mühlemann, O. (2014). A novel phosphorylation-independent interaction between SMG6 and UPF1 is essential for human NMD. Nucleic Acids Res. 42, 9217-9235.
    • (2014) Nucleic Acids Res , vol.42 , pp. 9217-9235
    • Nicholson, P.1    Josi, C.2    Kurosawa, H.3    Yamashita, A.4    Mühlemann, O.5
  • 100
    • 84957563051 scopus 로고    scopus 로고
    • Antisense oligonucleotide-directed inhibition of nonsense-mediated mRNA decay
    • in press [EPub]
    • Nomakuchi, T. T., Rigo, F., Aznarez, I. and Krainer, A. R. (2015). Antisense oligonucleotide-directed inhibition of nonsense-mediated mRNA decay. Nat. Biotechnol. 3, in press [EPub] doi: 10.1038/nbt.3427.
    • (2015) Nat. Biotechnol , vol.3
    • Nomakuchi, T.T.1    Rigo, F.2    Aznarez, I.3    Krainer, A.R.4
  • 102
    • 84856858152 scopus 로고    scopus 로고
    • N-and C-terminal Upf1 phosphorylations create binding platforms for SMG-6 and SMG-5:SMG-7 during NMD
    • Okada-Katsuhata, Y., Yamashita, A., Kutsuzawa, K., Izumi, N., Hirahara, F. and Ohno, S. (2012). N-and C-terminal Upf1 phosphorylations create binding platforms for SMG-6 and SMG-5:SMG-7 during NMD. Nucleic Acids Res. 40, 1251-1266.
    • (2012) Nucleic Acids Res , vol.40 , pp. 1251-1266
    • Okada-Katsuhata, Y.1    Yamashita, A.2    Kutsuzawa, K.3    Izumi, N.4    Hirahara, F.5    Ohno, S.6
  • 103
    • 30944449484 scopus 로고    scopus 로고
    • Quantitative microarray profiling provides evidence against widespread coupling of alternative splicing with nonsensemediated mRNA decay to control gene expression
    • Pan, Q., Saltzman, A. L., Kim, Y. K., Misquitta, C., Shai, O., Maquat, L. E., Frey, B. J. and Blencowe, B. J. (2006). Quantitative microarray profiling provides evidence against widespread coupling of alternative splicing with nonsensemediated mRNA decay to control gene expression. Genes Dev. 20, 153-158.
    • (2006) Genes Dev , vol.20 , pp. 153-158
    • Pan, Q.1    Saltzman, A.L.2    Kim, Y.K.3    Misquitta, C.4    Shai, O.5    Maquat, L.E.6    Frey, B.J.7    Blencowe, B.J.8
  • 104
    • 84856875524 scopus 로고    scopus 로고
    • Interaction of PABPC1 with the translation initiation complex is critical to the NMD resistance of AUG-proximal nonsense mutations
    • Peixeiro, I., Inácio, â., Barbosa, C., Silva, A. L., Liebhaber, S. A. and Romão, L. (2012). Interaction of PABPC1 with the translation initiation complex is critical to the NMD resistance of AUG-proximal nonsense mutations. Nucleic Acids Res. 40, 1160-1173.
    • (2012) Nucleic Acids Res , vol.40 , pp. 1160-1173
    • Peixeiro, I.1    Inácio, â.2    Barbosa, C.3    Silva, A.L.4    Liebhaber, S.A.5    Romão, L.6
  • 105
    • 84878916831 scopus 로고    scopus 로고
    • eIF4E-bound mRNPs are substrates for nonsense-mediated mRNA decay in mammalian cells
    • Rufener, S. C. and Mühlemann, O. (2013). eIF4E-bound mRNPs are substrates for nonsense-mediated mRNA decay in mammalian cells. Nat. Struct. Mol. Biol. 20, 710-717.
    • (2013) Nat. Struct. Mol. Biol , vol.20 , pp. 710-717
    • Rufener, S.C.1    Mühlemann, O.2
  • 106
    • 46149112362 scopus 로고    scopus 로고
    • Regulation of multiple core spliceosomal proteins by alternative splicing-coupled nonsense-mediated mRNA decay
    • Saltzman, A. L., Kim, Y. K., Pan, Q., Fagnani, M. M., Maquat, L. E. and Blencowe, B. J. (2008). Regulation of multiple core spliceosomal proteins by alternative splicing-coupled nonsense-mediated mRNA decay. Mol. Cell. Biol. 28, 4320-4330.
    • (2008) Mol. Cell. Biol , vol.28 , pp. 4320-4330
    • Saltzman, A.L.1    Kim, Y.K.2    Pan, Q.3    Fagnani, M.M.4    Maquat, L.E.5    Blencowe, B.J.6
  • 107
    • 70350639008 scopus 로고    scopus 로고
    • Remodeling of the pioneer translation initiation complex involves translation and the karyopherin importin beta
    • Sato, H. and Maquat, L. E. (2009). Remodeling of the pioneer translation initiation complex involves translation and the karyopherin importin beta. Genes Dev. 23, 2537-2550.
    • (2009) Genes Dev , vol.23 , pp. 2537-2550
    • Sato, H.1    Maquat, L.E.2
  • 109
    • 84941032369 scopus 로고    scopus 로고
    • Identification of SMG6 cleavage sites and a preferred RNA cleavage motif by global analysis of endogenous NMD targets in human cells
    • Schmidt, S. A., Foley, P. L., Jeong, D.-H., Rymarquis, L. A., Doyle, F., Tenenbaum, S. A., Belasco, J. G. and Green, P. J. (2015). Identification of SMG6 cleavage sites and a preferred RNA cleavage motif by global analysis of endogenous NMD targets in human cells. Nucleic Acids Res. 43, 309-323.
    • (2015) Nucleic Acids Res , vol.43 , pp. 309-323
    • Schmidt, S.A.1    Foley, P.L.2    Jeong, D.-H.3    Rymarquis, L.A.4    Doyle, F.5    Tenenbaum, S.A.6    Belasco, J.G.7    Green, P.J.8
  • 110
    • 0034751160 scopus 로고    scopus 로고
    • Identification and characterization of human orthologues to Saccharomyces cerevisiae Upf2 protein and Upf3 protein (Caenorhabditis elegans SMG-4)
    • Serin, G., Gersappe, A., Black, J. D., Aronoff, R. and Maquat, L. E. (2001). Identification and characterization of human orthologues to Saccharomyces cerevisiae Upf2 protein and Upf3 protein (Caenorhabditis elegans SMG-4). Mol. Cell. Biol. 21, 209-223.
    • (2001) Mol. Cell. Biol , vol.21 , pp. 209-223
    • Serin, G.1    Gersappe, A.2    Black, J.D.3    Aronoff, R.4    Maquat, L.E.5
  • 111
    • 84904813056 scopus 로고    scopus 로고
    • When proteins start to make sense: fine-tuning of aminoglycosides for PTC suppression therapy
    • Shalev, M. and Baasov, T. (2014). When proteins start to make sense: fine-tuning of aminoglycosides for PTC suppression therapy. MedChemComm. 5, 1092-1105.
    • (2014) MedChemComm , vol.5 , pp. 1092-1105
    • Shalev, M.1    Baasov, T.2
  • 112
    • 1842577707 scopus 로고    scopus 로고
    • eIF4AIII binds spliced mRNA in the exon junction complex and is essential for nonsensemediated decay
    • Shibuya, T., Tange, T. Ø., Sonenberg, N. and Moore, M. J. (2004). eIF4AIII binds spliced mRNA in the exon junction complex and is essential for nonsensemediated decay. Nat. Struct. Mol. Biol. 11, 346-351.
    • (2004) Nat. Struct. Mol. Biol , vol.11 , pp. 346-351
    • Shibuya, T.1    Tange, T.Ø.2    Sonenberg, N.3    Moore, M.J.4
  • 113
    • 84864933811 scopus 로고    scopus 로고
    • Evidence that the Upf1-related molecular motor scans the 3'-UTR to ensure mRNA integrity
    • Shigeoka, T., Kato, S., Kawaichi, M. and Ishida, Y. (2012). Evidence that the Upf1-related molecular motor scans the 3'-UTR to ensure mRNA integrity. Nucleic Acids Res. 40, 6887-6897.
    • (2012) Nucleic Acids Res , vol.40 , pp. 6887-6897
    • Shigeoka, T.1    Kato, S.2    Kawaichi, M.3    Ishida, Y.4
  • 114
    • 40449131535 scopus 로고    scopus 로고
    • Proximity of the poly(A)-binding protein to a premature termination codon inhibits mammalian nonsense-mediated mRNA decay
    • Silva, A. L., Ribeiro, P., Inácio, â., Ina, N. and Romão, S. A. (2008). Proximity of the poly(A)-binding protein to a premature termination codon inhibits mammalian nonsense-mediated mRNA decay. RNA 14, 563-576.
    • (2008) RNA , vol.14 , pp. 563-576
    • Silva, A.L.1    Ribeiro, P.2    Inácio, â.3    Ina, N.4    Romão, S.A.5
  • 115
    • 43249084802 scopus 로고    scopus 로고
    • A competition between stimulators and antagonists of Upf complex recruitment governs human nonsense-mediated mRNA decay
    • Singh, G., Rebbapragada, I. and Lykke-Andersen, J. (2008). A competition between stimulators and antagonists of Upf complex recruitment governs human nonsense-mediated mRNA decay. PLoS Biol. 6, e111.
    • (2008) PLoS Biol , vol.6
    • Singh, G.1    Rebbapragada, I.2    Lykke-Andersen, J.3
  • 116
    • 84869090905 scopus 로고    scopus 로고
    • The cellular EJC interactome reveals higher-order mRNP structure and an EJC-SR protein nexus
    • Singh, G., Kucukural, A., Cenik, C., Leszyk, J. D., Shaffer, S. A., Weng, Z. and Moore, M. J. (2012). The cellular EJC interactome reveals higher-order mRNP structure and an EJC-SR protein nexus. Cell 151, 750-764.
    • (2012) Cell , vol.151 , pp. 750-764
    • Singh, G.1    Kucukural, A.2    Cenik, C.3    Leszyk, J.D.4    Shaffer, S.A.5    Weng, Z.6    Moore, M.J.7
  • 117
    • 0035794679 scopus 로고    scopus 로고
    • SC35 autoregulates its expression by promoting splicing events that destabilize its mRNAs
    • Sureau, A., Gattoni, R., Dooghe, Y., Stévenin, J. and Soret, J. (2001). SC35 autoregulates its expression by promoting splicing events that destabilize its mRNAs. EMBO J. 20, 1785-1796.
    • (2001) EMBO J , vol.20 , pp. 1785-1796
    • Sureau, A.1    Gattoni, R.2    Dooghe, Y.3    Stévenin, J.4    Soret, J.5
  • 118
    • 84873828345 scopus 로고    scopus 로고
    • Identification of hundreds of novel UPF1 target transcripts by direct determination of whole transcriptome stability
    • Tani, H., Imamachi, N., Salam, K. A., Mizutani, R., Ijiri, K., Irie, T., Yada, T., Suzuki, Y. and Akimitsu, N. (2012). Identification of hundreds of novel UPF1 target transcripts by direct determination of whole transcriptome stability. RNA Biol. 9, 1370-1379.
    • (2012) RNA Biol , vol.9 , pp. 1370-1379
    • Tani, H.1    Imamachi, N.2    Salam, K.A.3    Mizutani, R.4    Ijiri, K.5    Irie, T.6    Yada, T.7    Suzuki, Y.8    Akimitsu, N.9
  • 120
    • 84928042455 scopus 로고    scopus 로고
    • Identification of elements in human long 3' UTRs that inhibit nonsense-mediated decay
    • Toma, K. G., Rebbapragada, I., Durand, S. and Lykke-Andersen, J. (2015). Identification of elements in human long 3' UTRs that inhibit nonsense-mediated decay. RNA 21, 887-897.
    • (2015) RNA , vol.21 , pp. 887-897
    • Toma, K.G.1    Rebbapragada, I.2    Durand, S.3    Lykke-Andersen, J.4
  • 121
    • 84874483832 scopus 로고    scopus 로고
    • Temporal and spatial characterization of nonsense-mediated mRNA decay
    • Trcek, T., Sato, H., Singer, R. H. and Maquat, L. E. (2013). Temporal and spatial characterization of nonsense-mediated mRNA decay. Genes Dev. 27, 541-551.
    • (2013) Genes Dev , vol.27 , pp. 541-551
    • Trcek, T.1    Sato, H.2    Singer, R.H.3    Maquat, L.E.4
  • 122
    • 0024349521 scopus 로고
    • Nonsense mutations in the dihydrofolate reductase gene affect RNA processing
    • Urlaub, G., Mitchell, P. J., Ciudad, C. J. and Chasin, L. A. (1989). Nonsense mutations in the dihydrofolate reductase gene affect RNA processing. Mol. Cell. Biol. 9, 2868-2880.
    • (1989) Mol. Cell. Biol , vol.9 , pp. 2868-2880
    • Urlaub, G.1    Mitchell, P.J.2    Ciudad, C.J.3    Chasin, L.A.4
  • 123
    • 2142656387 scopus 로고    scopus 로고
    • Inhibition of nonsense-mediated mRNA decay rescues the phenotype in Ullrich's disease
    • Usuki, F., Yamashita, A., Higuchi, I., Ohnishi, T., Shiraishi, T., Osame, M. and Ohno, S. (2004). Inhibition of nonsense-mediated mRNA decay rescues the phenotype in Ullrich's disease. Ann. Neurol. 55, 740-744.
    • (2004) Ann. Neurol , vol.55 , pp. 740-744
    • Usuki, F.1    Yamashita, A.2    Higuchi, I.3    Ohnishi, T.4    Shiraishi, T.5    Osame, M.6    Ohno, S.7
  • 124
    • 29844451724 scopus 로고    scopus 로고
    • A 3' UTR sequence stabilizes termination codons in the unspliced RNA of Rous sarcoma virus
    • Weil, J. E. and Beemon, K. L. (2006). A 3' UTR sequence stabilizes termination codons in the unspliced RNA of Rous sarcoma virus. RNA 12, 102-110.
    • (2006) RNA , vol.12 , pp. 102-110
    • Weil, J.E.1    Beemon, K.L.2
  • 125
    • 60049088883 scopus 로고    scopus 로고
    • Structural characterization of the Rous sarcoma virus RNA stability element
    • Weil, J. E., Hadjithomas, M. and Beemon, K. L. (2009). Structural characterization of the Rous sarcoma virus RNA stability element. J. Virol. 83, 2119-2129.
    • (2009) J. Virol , vol.83 , pp. 2119-2129
    • Weil, J.E.1    Hadjithomas, M.2    Beemon, K.L.3
  • 127
    • 0035449691 scopus 로고    scopus 로고
    • Human SMG-1, a novel phosphatidylinositol 3-kinase-related protein kinase, associates with components of the mRNA surveillance complex and is involved in the regulation of nonsense-mediated mRNA decay
    • Yamashita, A., Ohnishi, T., Kashima, I., Taya, Y. and Ohno, S. (2001). Human SMG-1, a novel phosphatidylinositol 3-kinase-related protein kinase, associates with components of the mRNA surveillance complex and is involved in the regulation of nonsense-mediated mRNA decay. Genes Dev. 15, 2215-2228.
    • (2001) Genes Dev , vol.15 , pp. 2215-2228
    • Yamashita, A.1    Ohnishi, T.2    Kashima, I.3    Taya, Y.4    Ohno, S.5
  • 128
    • 65449178454 scopus 로고    scopus 로고
    • SMG-8 and SMG-9, two novel subunits of the SMG-1 complex, regulate remodeling of the mRNA surveillance complex during nonsense-mediated mRNA decay
    • Yamashita, A., Izumi, N., Kashima, I., Ohnishi, T., Saari, B., Katsuhata, Y., Muramatsu, R., Morita, T., Iwamatsu, A., Hachiya, T. et al. (2009). SMG-8 and SMG-9, two novel subunits of the SMG-1 complex, regulate remodeling of the mRNA surveillance complex during nonsense-mediated mRNA decay. Genes Dev. 23, 1091-1105.
    • (2009) Genes Dev , vol.23 , pp. 1091-1105
    • Yamashita, A.1    Izumi, N.2    Kashima, I.3    Ohnishi, T.4    Saari, B.5    Katsuhata, Y.6    Muramatsu, R.7    Morita, T.8    Iwamatsu, A.9    Hachiya, T.10
  • 129
    • 0031870169 scopus 로고    scopus 로고
    • Intron function in the nonsense-mediated decay of beta-globin mRNA: indications that pre-mRNA splicing in the nucleus can influence mRNA translation in the cytoplasm
    • Zhang, J., Sun, X., Qian, Y. and Maquat, L. E. (1998a). Intron function in the nonsense-mediated decay of beta-globin mRNA: indications that pre-mRNA splicing in the nucleus can influence mRNA translation in the cytoplasm. RNA 4, 801-815.
    • (1998) RNA , vol.4 , pp. 801-815
    • Zhang, J.1    Sun, X.2    Qian, Y.3    Maquat, L.E.4
  • 130
    • 0031840487 scopus 로고    scopus 로고
    • At least one intron is required for the nonsense-mediated decay of triosephosphate isomerase mRNA: a possible link between nuclear splicing and cytoplasmic translation
    • Zhang, J., Sun, X., Qian, Y., LaDuca, J. P. and Maquat, L. E. (1998b). At least one intron is required for the nonsense-mediated decay of triosephosphate isomerase mRNA: a possible link between nuclear splicing and cytoplasmic translation. Mol. Cell. Biol. 18, 5272-5283.
    • (1998) Mol. Cell. Biol , vol.18 , pp. 5272-5283
    • Zhang, J.1    Sun, X.2    Qian, Y.3    LaDuca, J.P.4    Maquat, L.E.5
  • 131
    • 84881477715 scopus 로고    scopus 로고
    • Translationdependent displacement of UPF1 from coding sequences causes its enrichment in 3' UTRs
    • Zünd, D., Gruber, A. R., Zavolan, M. and Mühlemann, O. (2013). Translationdependent displacement of UPF1 from coding sequences causes its enrichment in 3' UTRs. Nat. Struct. Mol. Biol. 20, 936-943.
    • (2013) Nat. Struct. Mol. Biol , vol.20 , pp. 936-943
    • Zünd, D.1    Gruber, A.R.2    Zavolan, M.3    Mühlemann, O.4


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