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Volumn 127, Issue 1, 2016, Pages 42-52

Epigenetics and approaches to targeted epigenetic therapy in acute myeloid leukemia

Author keywords

[No Author keywords available]

Indexed keywords

5 HYDROXYMETHYLCYTOSINE; 5 METHYLCYTOSINE; AZACITIDINE; CYTARABINE; DECITABINE; DNA METHYLTRANSFERASE 3A; HISTONE DEACETYLASE 2; HISTONE DEACETYLASE 3; HISTONE DEMETHYLASE; IDARUBICIN; ISOCITRATE DEHYDROGENASE 1; ISOCITRATE DEHYDROGENASE 2; POLYCOMB REPRESSIVE COMPLEX 2; PROTEIN; PROTEIN ARGININE METHYLTRANSFERASE; PROTEIN ASXL1; PROTEIN JARID2; TRANSCRIPTION FACTOR EZH2; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG; VALPROIC ACID; VORINOSTAT; ANTINEOPLASTIC AGENT;

EID: 84955512077     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2015-07-604512     Document Type: Review
Times cited : (238)

References (140)
  • 1
    • 84873580363 scopus 로고    scopus 로고
    • Acute myeloid leukaemia in adults
    • Ferrara F, Schiffer CA. Acute myeloid leukaemia in adults. Lancet. 2013;381(9865):484-495.
    • (2013) Lancet , vol.381 , Issue.9865 , pp. 484-495
    • Ferrara, F.1    Schiffer, C.A.2
  • 2
    • 79952086942 scopus 로고    scopus 로고
    • Therapeutic advances in acute myeloid leukemia
    • Burnett A, Wetzler M, Lowenberg B. Therapeutic advances in acute myeloid leukemia. J Clin Oncol. 2011;29(5):487-494.
    • (2011) J Clin Oncol , vol.29 , Issue.5 , pp. 487-494
    • Burnett, A.1    Wetzler, M.2    Lowenberg, B.3
  • 3
    • 2642531973 scopus 로고    scopus 로고
    • Epigenetics in human disease and prospects for epigenetic therapy
    • Egger G, Liang G, Aparicio A, Jones PA. Epigenetics in human disease and prospects for epigenetic therapy. Nature. 2004;429(6990): 457-463.
    • (2004) Nature , vol.429 , Issue.6990 , pp. 457-463
    • Egger, G.1    Liang, G.2    Aparicio, A.3    Jones, P.A.4
  • 4
    • 84879698783 scopus 로고    scopus 로고
    • Mutations in epigenetic modifiers in the pathogenesis and therapy of acute myeloid leukemia
    • Abdel-Wahab O, Levine RL. Mutations in epigenetic modifiers in the pathogenesis and therapy of acute myeloid leukemia. Blood. 2013; 121(18):3563-3572.
    • (2013) Blood , vol.121 , Issue.18 , pp. 3563-3572
    • Abdel-Wahab, O.1    Levine, R.L.2
  • 5
    • 84919339903 scopus 로고    scopus 로고
    • Epigenetics in the hematologic malignancies
    • Fong CY, Morison J, Dawson MA. Epigenetics in the hematologic malignancies. Haematologica. 2014;99(12):1772-1783.
    • (2014) Haematologica , vol.99 , Issue.12 , pp. 1772-1783
    • Fong, C.Y.1    Morison, J.2    Dawson, M.A.3
  • 6
    • 84904070819 scopus 로고    scopus 로고
    • Chromatin modifiers and the promise of epigenetic therapy in acute leukemia
    • Greenblatt SM, Nimer SD. Chromatin modifiers and the promise of epigenetic therapy in acute leukemia. Leukemia. 2014;28(7):1396-1406.
    • (2014) Leukemia , vol.28 , Issue.7 , pp. 1396-1406
    • Greenblatt, S.M.1    Nimer, S.D.2
  • 7
    • 84878372012 scopus 로고    scopus 로고
    • Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia
    • Cancer Genome Atlas Research Network
    • Cancer Genome Atlas Research Network. Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia. N Engl J Med. 2013;368(22):2059-2074.
    • (2013) N Engl J Med , vol.368 , Issue.22 , pp. 2059-2074
  • 8
    • 73649110641 scopus 로고    scopus 로고
    • DNA methylation signatures identify biologically distinct subtypes in acute myeloid leukemia
    • Figueroa ME, Lugthart S, Li Y, et al. DNA methylation signatures identify biologically distinct subtypes in acute myeloid leukemia. Cancer Cell. 2010;17(1):13-27.
    • (2010) Cancer Cell , vol.17 , Issue.1 , pp. 13-27
    • Figueroa, M.E.1    Lugthart, S.2    Li, Y.3
  • 9
    • 84898494315 scopus 로고    scopus 로고
    • A single oncogenic enhancer rearrangement causes concomitant EVI1 and GATA2 deregulation in leukemia
    • Groschel S, Sanders MA, Hoogenboezem R, et al. A single oncogenic enhancer rearrangement causes concomitant EVI1 and GATA2 deregulation in leukemia. Cell. 2014; 157(2):369-381.
    • (2014) Cell , vol.157 , Issue.2 , pp. 369-381
    • Groschel, S.1    Sanders, M.A.2    Hoogenboezem, R.3
  • 10
    • 84920053873 scopus 로고    scopus 로고
    • Age-related clonal hematopoiesis associated with adverse outcome
    • Jaiswal S, Fontanillas P, Flannick J, et al. Age-related clonal hematopoiesis associated with adverse outcome. N Engl J Med. 2014;371(26):2488-2498.
    • (2014) N Engl J Med , vol.371 , Issue.26 , pp. 2488-2498
    • Jaiswal, S.1    Fontanillas, P.2    Flannick, J.3
  • 11
    • 84862502902 scopus 로고    scopus 로고
    • Mutant DNMT3A: A marker of poor prognosis in acute myeloid leukemia
    • Ribeiro AF, Pratcorona M, Erpelinck- Verschueren C, et al. Mutant DNMT3A: A marker of poor prognosis in acute myeloid leukemia. Blood. 2012;119(24):5824-5831.
    • (2012) Blood , vol.119 , Issue.24 , pp. 5824-5831
    • Ribeiro, A.F.1    Pratcorona, M.2    Erpelinck-, V.C.3
  • 12
    • 78649906060 scopus 로고    scopus 로고
    • DNMT3A mutations in acute myeloid leukemia
    • Ley TJ, Ding L, Walter MJ, et al. DNMT3A mutations in acute myeloid leukemia. N Engl J Med. 2010;363(25):2424-2433.
    • (2010) N Engl J Med , vol.363 , Issue.25 , pp. 2424-2433
    • Ley, T.J.1    Ding, L.2    Walter, M.J.3
  • 13
    • 79953176952 scopus 로고    scopus 로고
    • Exome sequencing identifies somatic mutations of DNA methyltransferase gene DNMT3A in acute monocytic leukemia
    • Yan XJ, Xu J, Gu ZH, et al. Exome sequencing identifies somatic mutations of DNA methyltransferase gene DNMT3A in acute monocytic leukemia. Nat Genet. 2011;43(4): 309-315.
    • (2011) Nat Genet , vol.43 , Issue.4 , pp. 309-315
    • Yan, X.J.1    Xu, J.2    Gu, Z.H.3
  • 14
    • 84863116398 scopus 로고    scopus 로고
    • Agerelated prognostic impact of different types of DNMT3A mutations in adults with primary cytogenetically normal acute myeloid leukemia
    • Marcucci G, Metzeler KH, Schwind S, et al. Agerelated prognostic impact of different types of DNMT3A mutations in adults with primary cytogenetically normal acute myeloid leukemia. J Clin Oncol. 2012;30(7):742-750.
    • (2012) J Clin Oncol , vol.30 , Issue.7 , pp. 742-750
    • Marcucci, G.1    Metzeler, K.H.2    Schwind, S.3
  • 15
    • 84863393263 scopus 로고    scopus 로고
    • Prognostic relevance of integrated genetic profiling in acute myeloid leukemia
    • Patel JP, Gonen M, Figueroa ME, et al. Prognostic relevance of integrated genetic profiling in acute myeloid leukemia. N Engl J Med. 2012;366(12):1079-1089.
    • (2012) N Engl J Med , vol.366 , Issue.12 , pp. 1079-1089
    • Patel, J.P.1    Gonen, M.2    Figueroa, M.E.3
  • 16
    • 81555228423 scopus 로고    scopus 로고
    • Gene mutation patterns and their prognostic impact in a cohort of 1185 patients with acute myeloid leukemia
    • Shen Y, Zhu YM, Fan X, et al. Gene mutation patterns and their prognostic impact in a cohort of 1185 patients with acute myeloid leukemia. Blood. 2011;118(20):5593-5603.
    • (2011) Blood , vol.118 , Issue.20 , pp. 5593-5603
    • Shen, Y.1    Zhu, Y.M.2    Fan, X.3
  • 17
    • 79954428737 scopus 로고    scopus 로고
    • TET2 mutations improve the new European LeukemiaNet risk classification of acute myeloid leukemia: A Cancer and Leukemia Group B study
    • Metzeler KH, Maharry K, Radmacher MD, et al. TET2 mutations improve the new European LeukemiaNet risk classification of acute myeloid leukemia: A Cancer and Leukemia Group B study. J Clin Oncol. 2011;29(10):1373-1381.
    • (2011) J Clin Oncol , vol.29 , Issue.10 , pp. 1373-1381
    • Metzeler, K.H.1    Maharry, K.2    Radmacher, M.D.3
  • 18
    • 66249137734 scopus 로고    scopus 로고
    • Mutation in TET2 in myeloid cancers
    • Delhommeau F, Dupont S, Della Valle V, et al. Mutation in TET2 in myeloid cancers. N Engl J Med. 2009;360(22):2289-2301.
    • (2009) N Engl J Med , vol.360 , Issue.22 , pp. 2289-2301
    • Delhommeau, F.1    Dupont, S.2    Della Valle, V.3
  • 19
    • 80053620171 scopus 로고    scopus 로고
    • TET2 mutation is an unfavorable prognostic factor in acute myeloid leukemia patients with intermediate-risk cytogenetics
    • Chou WC, Chou SC, Liu CY, et al. TET2 mutation is an unfavorable prognostic factor in acute myeloid leukemia patients with intermediate-risk cytogenetics. Blood. 2011; 118(14):3803-3810.
    • (2011) Blood , vol.118 , Issue.14 , pp. 3803-3810
    • Chou, W.C.1    Chou, S.C.2    Liu, C.Y.3
  • 20
    • 84860703461 scopus 로고    scopus 로고
    • Landscape of TET2 mutations in acute myeloid leukemia
    • Weissmann S, Alpermann T, Grossmann V, et al. Landscape of TET2 mutations in acute myeloid leukemia. Leukemia. 2012;26(5): 934-942.
    • (2012) Leukemia , vol.26 , Issue.5 , pp. 934-942
    • Weissmann, S.1    Alpermann, T.2    Grossmann, V.3
  • 21
    • 84862266735 scopus 로고    scopus 로고
    • TET2 mutations in acute myeloid leukemia (AML): Results from a comprehensive genetic and clinical analysis of the AML study group
    • Gaidzik VI, Paschka P, Spath D, et al. TET2 mutations in acute myeloid leukemia (AML): results from a comprehensive genetic and clinical analysis of the AML study group. J Clin Oncol. 2012;30(12):1350-1357.
    • (2012) J Clin Oncol , vol.30 , Issue.12 , pp. 1350-1357
    • Gaidzik, V.I.1    Paschka, P.2    Spath, D.3
  • 22
    • 77957192661 scopus 로고    scopus 로고
    • Acquired mutations in the genes encoding IDH1 and IDH2 both are recurrent aberrations in acute myeloid leukemia: Prevalence and prognostic value
    • Abbas S, Lugthart S, Kavelaars FG, et al. Acquired mutations in the genes encoding IDH1 and IDH2 both are recurrent aberrations in acute myeloid leukemia: prevalence and prognostic value. Blood. 2010;116(12):2122-2126.
    • (2010) Blood , vol.116 , Issue.12 , pp. 2122-2126
    • Abbas, S.1    Lugthart, S.2    Kavelaars, F.G.3
  • 23
    • 77955907891 scopus 로고    scopus 로고
    • IDH1 and IDH2 mutations are frequent genetic alterations in acute myeloid leukemia and confer adverse prognosis in cytogenetically normal acute myeloid leukemia with NPM1 mutation without FLT3 internal tandem duplication
    • Paschka P, Schlenk RF, Gaidzik VI, et al. IDH1 and IDH2 mutations are frequent genetic alterations in acute myeloid leukemia and confer adverse prognosis in cytogenetically normal acute myeloid leukemia with NPM1 mutation without FLT3 internal tandem duplication. J Clin Oncol. 2010;28(22):3636-3643.
    • (2010) J Clin Oncol , vol.28 , Issue.22 , pp. 3636-3643
    • Paschka, P.1    Schlenk, R.F.2    Gaidzik, V.I.3
  • 24
    • 77952536841 scopus 로고    scopus 로고
    • IDH1 and IDH2 gene mutations identify novel molecular subsets within de novo cytogenetically normal acute myeloid leukemia: A Cancer and Leukemia Group B study
    • Marcucci G, Maharry K, Wu YZ, et al. IDH1 and IDH2 gene mutations identify novel molecular subsets within de novo cytogenetically normal acute myeloid leukemia: A Cancer and Leukemia Group B study. J Clin Oncol. 2010;28(14): 2348-2355.
    • (2010) J Clin Oncol , vol.28 , Issue.14 , pp. 2348-2355
    • Marcucci, G.1    Maharry, K.2    Wu, Y.Z.3
  • 25
    • 2342464348 scopus 로고    scopus 로고
    • Type I MOZ/CBP (MYST3/CREBBP) is the most common chimeric transcript in acute myeloid leukemia with t(8;16)(p11;p13) translocation
    • Rozman M, Camos M, Colomer D, et al. Type I MOZ/CBP (MYST3/CREBBP) is the most common chimeric transcript in acute myeloid leukemia with t(8;16)(p11;p13) translocation. Genes Chromosomes Cancer. 2004;40(2): 140-145.
    • (2004) Genes Chromosomes, Cancer , vol.40 , Issue.2 , pp. 140-145
    • Rozman, M.1    Camos, M.2    Colomer, D.3
  • 26
    • 49449088890 scopus 로고    scopus 로고
    • Groupe francophone de cytogeńetique hematologique. Acute myeloid leukaemia with 8p11 (MYST3) rearrangement: An integrated cytologic, cytogenetic and molecular study by the groupe francophone de cytogeńetique hematologique
    • Gervais C, Murati A, Helias C, et al; Groupe Francophone de Cytogeńetique Hematologique. Acute myeloid leukaemia with 8p11 (MYST3) rearrangement: An integrated cytologic, cytogenetic and molecular study by the groupe francophone de cytogeńetique hematologique. Leukemia. 2008;22(8):1567-1575.
    • (2008) Leukemia , vol.22 , Issue.8 , pp. 1567-1575
    • Gervais, C.1    Murati, A.2    Helias, C.3
  • 27
    • 0031439397 scopus 로고    scopus 로고
    • Adenoviral E1A-Associated protein p300 is involved in acute myeloid leukemia with t(11;22)(q23;q13)
    • Ida K, Kitabayashi I, Taki T, et al. Adenoviral E1A-Associated protein p300 is involved in acute myeloid leukemia with t(11;22)(q23;q13). Blood. 1997;90(12):4699-4704.
    • (1997) Blood , vol.90 , Issue.12 , pp. 4699-4704
    • Ida, K.1    Kitabayashi, I.2    Taki, T.3
  • 28
    • 0030792867 scopus 로고    scopus 로고
    • All patients with the T(11;16)(q23;p13.3) that involves MLL and CBP have treatment-related hematologic disorders
    • Rowley JD, Reshmi S, Sobulo O, et al. All patients with the T(11;16)(q23;p13.3) that involves MLL and CBP have treatment-related hematologic disorders. Blood. 1997;90(2): 535-541.
    • (1997) Blood , vol.90 , Issue.2 , pp. 535-541
    • Rowley, J.D.1    Reshmi, S.2    Sobulo, O.3
  • 29
    • 35548934558 scopus 로고    scopus 로고
    • MLL translocations, histone modifications and leukaemia stem-cell development
    • Krivtsov AV, Armstrong SA. MLL translocations, histone modifications and leukaemia stem-cell development. Nat Rev Cancer. 2007;7(11): 823-833.
    • (2007) Nat Rev Cancer , vol.7 , Issue.11 , pp. 823-833
    • Krivtsov, A.V.1    Armstrong, S.A.2
  • 30
    • 0037114753 scopus 로고    scopus 로고
    • Cancer and Leukemia Group B (CALGB 8461). Pretreatment cytogenetic abnormalities are predictive of induction success, cumulative incidence of relapse, and overall survival in adult patients with de novo acute myeloid leukemia: Results from Cancer and Leukemia Group B (CALGB 8461)
    • Byrd JC, Mŕozek K, Dodge RK, et al; Cancer and Leukemia Group B (CALGB 8461). Pretreatment cytogenetic abnormalities are predictive of induction success, cumulative incidence of relapse, and overall survival in adult patients with de novo acute myeloid leukemia: results from Cancer and Leukemia Group B (CALGB 8461). Blood. 2002;100(13):4325-4336.
    • (2002) Blood , vol.100 , Issue.13 , pp. 4325-4336
    • Byrd, J.C.1    Mŕozek, K.2    Dodge, R.K.3
  • 31
    • 0035469883 scopus 로고    scopus 로고
    • Medical Research Council Adult Leukemia Working Party. The predictive value of hierarchical cytogenetic classification in older adults with acute myeloid leukemia (AML): Analysis of 1065 patients entered into the United Kingdom Medical Research Council AML11 trial
    • Grimwade D, Walker H, Harrison G, et al; Medical Research Council Adult Leukemia Working Party. The predictive value of hierarchical cytogenetic classification in older adults with acute myeloid leukemia (AML): Analysis of 1065 patients entered into the United Kingdom Medical Research Council AML11 trial. Blood. 2001;98(5):1312-1320.
    • (2001) Blood , vol.98 , Issue.5 , pp. 1312-1320
    • Grimwade, D.1    Walker, H.2    Harrison, G.3
  • 32
    • 0034672269 scopus 로고    scopus 로고
    • Karyotypic analysis predicts outcome of preremission and postremission therapy in adult acute myeloid leukemia: A Southwest Oncology Group/Eastern Cooperative Oncology Group Study
    • Slovak ML, Kopecky KJ, Cassileth PA, et al. Karyotypic analysis predicts outcome of preremission and postremission therapy in adult acute myeloid leukemia: A Southwest Oncology Group/Eastern Cooperative Oncology Group Study. Blood. 2000;96(13):4075-4083.
    • (2000) Blood , vol.96 , Issue.13 , pp. 4075-4083
    • Slovak, M.L.1    Kopecky, K.J.2    Cassileth, P.A.3
  • 33
    • 84876260322 scopus 로고    scopus 로고
    • EZH2 mutations are related to low blast percentage in bone marrow and -7/del(7q) in de novo acute myeloid leukemia
    • Wang X, Dai H, Wang Q, et al. EZH2 mutations are related to low blast percentage in bone marrow and -7/del(7q) in de novo acute myeloid leukemia. PLoS One. 2013;8(4):e61341.
    • (2013) PLoS One. , vol.8 , Issue.4 , pp. e61341
    • Wang, X.1    Dai, H.2    Wang, Q.3
  • 34
    • 0036530203 scopus 로고    scopus 로고
    • A cryptic t(5; 11)(q35;p15.5) in 2 children with acute myeloid leukemia with apparently normal karyotypes, identified by a multiplex fluorescence in situ hybridization telomere assay
    • Brown J, Jawad M, Twigg SR, et al. A cryptic t(5; 11)(q35;p15.5) in 2 children with acute myeloid leukemia with apparently normal karyotypes, identified by a multiplex fluorescence in situ hybridization telomere assay. Blood. 2002;99(7): 2526-2531.
    • (2002) Blood , vol.99 , Issue.7 , pp. 2526-2531
    • Brown, J.1    Jawad, M.2    Twigg, S.R.3
  • 35
    • 10744231835 scopus 로고    scopus 로고
    • Frequency of NUP98-NSD1 fusion transcript in childhood acute myeloid leukaemia
    • Cerveira N, Correia C, D oria S, et al. Frequency of NUP98-NSD1 fusion transcript in childhood acute myeloid leukaemia. Leukemia. 2003; 17(11):2244-2247.
    • (2003) Leukemia , vol.17 , Issue.11 , pp. 2244-2247
    • Cerveira, N.1    Correia, C.2    D, O.S.3
  • 36
    • 84924662543 scopus 로고    scopus 로고
    • ASXL1 mutations in younger adult patients with acute myeloid leukemia: A study by the German- Austrian Acute Myeloid Leukemia Study Group
    • Paschka P, Schlenk RF, Gaidzik VI, et al. ASXL1 mutations in younger adult patients with acute myeloid leukemia: A study by the German- Austrian Acute Myeloid Leukemia Study Group. Haematologica. 2015;100(3):324-330.
    • (2015) Haematologica , vol.100 , Issue.3 , pp. 324-330
    • Paschka, P.1    Schlenk, R.F.2    Gaidzik, V.I.3
  • 37
    • 78549279199 scopus 로고    scopus 로고
    • Distinct clinical and biological features of de novo acute myeloid leukemia with additional sex comb-like 1 (ASXL1) mutations
    • Chou WC, Huang HH, Hou HA, et al. Distinct clinical and biological features of de novo acute myeloid leukemia with additional sex comb-like 1 (ASXL1) mutations. Blood. 2010;116(20): 4086-4094.
    • (2010) Blood , vol.116 , Issue.20 , pp. 4086-4094
    • Chou, W.C.1    Huang, H.H.2    Hou, H.A.3
  • 38
    • 84255176496 scopus 로고    scopus 로고
    • ASXL1 mutations identify a high-risk subgroup of older patients with primary cytogenetically normal AML within the ELN Favorable genetic category
    • Metzeler KH, Becker H, Maharry K, et al. ASXL1 mutations identify a high-risk subgroup of older patients with primary cytogenetically normal AML within the ELN Favorable genetic category. Blood. 2011;118(26):6920-6929.
    • (2011) Blood , vol.118 , Issue.26 , pp. 6920-6929
    • Metzeler, K.H.1    Becker, H.2    Maharry, K.3
  • 39
    • 84873568769 scopus 로고    scopus 로고
    • ASXL1 exon 12 mutations are frequent in AML with intermediate risk karyotype and are independently associated with an adverse outcome
    • Schnittger S, Eder C, Jeromin S, et al. ASXL1 exon 12 mutations are frequent in AML with intermediate risk karyotype and are independently associated with an adverse outcome. Leukemia. 2013;27(1):82-91.
    • (2013) Leukemia , vol.27 , Issue.1 , pp. 82-91
    • Schnittger, S.1    Eder, C.2    Jeromin, S.3
  • 40
    • 84901308956 scopus 로고    scopus 로고
    • ASXL1 mutations are infrequent in young patients with primary acute myeloid leukemia and their detection has a limited role in therapeutic risk stratification
    • El-Sharkawi D, Ali A, Evans CM, et al. ASXL1 mutations are infrequent in young patients with primary acute myeloid leukemia and their detection has a limited role in therapeutic risk stratification. Leuk Lymphoma. 2014;55(6): 1326-1331.
    • (2014) Leuk Lymphoma , vol.55 , Issue.6 , pp. 1326-1331
    • El-Sharkawi, D.1    Ali, A.2    Evans, C.M.3
  • 41
    • 77952421834 scopus 로고    scopus 로고
    • Frequent mutation of the polycomb-Associated gene ASXL1 in the myelodysplastic syndromes and in acute myeloid leukemia
    • Boultwood J, Perry J, Pellagatti A, et al. Frequent mutation of the polycomb-Associated gene ASXL1 in the myelodysplastic syndromes and in acute myeloid leukemia. Leukemia. 2010;24(5): 1062-1065.
    • (2010) Leukemia , vol.24 , Issue.5 , pp. 1062-1065
    • Boultwood, J.1    Perry, J.2    Pellagatti, A.3
  • 42
    • 84907344294 scopus 로고    scopus 로고
    • Frequent ASXL2 mutations in acute myeloid leukemia patients with t(8;21)/RUNX1-RUNX1T1 chromosomal translocations
    • Micol JB, Duployez N, Boissel N, et al. Frequent ASXL2 mutations in acute myeloid leukemia patients with t(8;21)/RUNX1-RUNX1T1 chromosomal translocations. Blood. 2014; 124(9):1445-1449.
    • (2014) Blood , vol.124 , Issue.9 , pp. 1445-1449
    • Micol, J.B.1    Duployez, N.2    Boissel, N.3
  • 43
    • 84857051756 scopus 로고    scopus 로고
    • Frequent deletions of JARID2 in leukemic transformation of chronic myeloid malignancies
    • Puda A, Milosevic JD, Berg T, et al. Frequent deletions of JARID2 in leukemic transformation of chronic myeloid malignancies. Am J Hematol. 2012;87(3):245-250.
    • (2012) Am J Hematol , vol.87 , Issue.3 , pp. 245-250
    • Puda, A.1    Milosevic, J.D.2    Berg, T.3
  • 44
    • 84861813715 scopus 로고    scopus 로고
    • Sequential gain of mutations in severe congenital neutropenia progressing to acute myeloid leukemia
    • Beekman R, Valkhof MG, Sanders MA, et al. Sequential gain of mutations in severe congenital neutropenia progressing to acute myeloid leukemia. Blood. 2012;119(22): 5071-5077.
    • (2012) Blood , vol.119 , Issue.22 , pp. 5071-5077
    • Beekman, R.1    Valkhof, M.G.2    Sanders, M.A.3
  • 45
    • 84890434451 scopus 로고    scopus 로고
    • NUP98/JARID1A is a novel recurrent abnormality in pediatric acute megakaryoblastic leukemia with a distinct HOX gene expression pattern
    • de Rooij JD, Hollink IH, Arentsen-Peters ST, et al. NUP98/JARID1A is a novel recurrent abnormality in pediatric acute megakaryoblastic leukemia with a distinct HOX gene expression pattern. Leukemia. 2013;27(12):2280-2288.
    • (2013) Leukemia , vol.27 , Issue.12 , pp. 2280-2288
    • De Rooij, J.D.1    Hollink, I.H.2    Arentsen-Peters, S.T.3
  • 46
    • 67349203626 scopus 로고    scopus 로고
    • Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer
    • van Haaften G, Dalgliesh GL, Davies H, et al. Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer. Nat Genet. 2009;41(5):521-523.
    • (2009) Nat Genet , vol.41 , Issue.5 , pp. 521-523
    • Van Haaften, G.1    Dalgliesh, G.L.2    Davies, H.3
  • 47
    • 80053144962 scopus 로고    scopus 로고
    • A decade of exploring the cancer epigenome - biological and translational implications
    • Baylin SB, Jones PA. A decade of exploring the cancer epigenome - biological and translational implications. Nat Rev Cancer. 2011;11(10): 726-734.
    • (2011) Nat Rev Cancer , vol.11 , Issue.10 , pp. 726-734
    • Baylin, S.B.1    Jones, P.A.2
  • 48
    • 84894245627 scopus 로고    scopus 로고
    • HALT Pan- leukemia gene panel consortium. Identification of pre-leukaemic haematopoietic stem cells in acute leukaemia
    • Shlush LI, Zandi S, Mitchell A, et al; HALT Pan- Leukemia Gene Panel Consortium. Identification of pre-leukaemic haematopoietic stem cells in acute leukaemia. Nature. 2014;506(7488): 328-333.
    • (2014) Nature , vol.506 , Issue.7488 , pp. 328-333
    • Shlush, L.I.1    Zandi, S.2    Mitchell, A.3
  • 49
    • 84898545028 scopus 로고    scopus 로고
    • The R882H DNMT3A mutation associated with AML dominantly inhibits wild-type DNMT3A by blocking its ability to form active tetramers
    • Russler-Germain DA, Spencer DH, Young MA, et al. The R882H DNMT3A mutation associated with AML dominantly inhibits wild-type DNMT3A by blocking its ability to form active tetramers. Cancer Cell. 2014;25(4):442-454.
    • (2014) Cancer Cell , vol.25 , Issue.4 , pp. 442-454
    • Russler-Germain, D.A.1    Spencer, D.H.2    Young, M.A.3
  • 50
    • 84555207349 scopus 로고    scopus 로고
    • Dnmt3a is essential for hematopoietic stem cell differentiation
    • Challen GA, Sun D, Jeong M, et al. Dnmt3a is essential for hematopoietic stem cell differentiation. Nat Genet. 2012;44(1):23-31.
    • (2012) Nat Genet , vol.44 , Issue.1 , pp. 23-31
    • Challen, G.A.1    Sun, D.2    Jeong, M.3
  • 51
    • 84921468426 scopus 로고    scopus 로고
    • Dnmt3a loss predisposes murine hematopoietic stem cells to malignant transformation
    • Mayle A, Yang L, Rodriguez B, et al. Dnmt3a loss predisposes murine hematopoietic stem cells to malignant transformation. Blood. 2015; 125(4):629-638.
    • (2015) Blood , vol.125 , Issue.4 , pp. 629-638
    • Mayle, A.1    Yang, L.2    Rodriguez, B.3
  • 52
    • 84921517163 scopus 로고    scopus 로고
    • Enforced differentiation of Dnmt3a-null bone marrow leads to failure with c-Kit mutations driving leukemic transformation
    • Celik H, Mallaney C, Kothari A, et al. Enforced differentiation of Dnmt3a-null bone marrow leads to failure with c-Kit mutations driving leukemic transformation. Blood. 2015;125(4):619-628.
    • (2015) Blood , vol.125 , Issue.4 , pp. 619-628
    • Celik, H.1    Mallaney, C.2    Kothari, A.3
  • 53
    • 84955464293 scopus 로고    scopus 로고
    • DNMT3A R882 mutation promote chemoresistance and therapeutic relapse through impaired DNA-damage sensing
    • Vienna, Austria
    • Guryanova O, Shank K, Garrett-Bakelman F, et al. DNMT3A R882 mutation promote chemoresistance and therapeutic relapse through impaired DNA-damage sensing. EHA Annual Meeting, Vienna, Austria, 2015.
    • (2015) EHA Annual Meeting
    • Guryanova, O.1    Shank, K.2    Garrett-Bakelman, F.3
  • 54
    • 78650983952 scopus 로고    scopus 로고
    • Aberrant DNA hypermethylation signature in acute myeloid leukemia directed by EVI1
    • Lugthart S, Figueroa ME, Bindels E, et al. Aberrant DNA hypermethylation signature in acute myeloid leukemia directed by EVI1. Blood. 2011;117(1):234-241.
    • (2011) Blood , vol.117 , Issue.1 , pp. 234-241
    • Lugthart, S.1    Figueroa, M.E.2    Bindels, E.3
  • 55
    • 78449270555 scopus 로고    scopus 로고
    • PML-RARalpha and Dnmt3a1 cooperate in vivo to promote acute promyelocytic leukemia
    • Subramanyam D, Belair CD, Barry-Holson KQ, et al. PML-RARalpha and Dnmt3a1 cooperate in vivo to promote acute promyelocytic leukemia. Cancer Res. 2010;70(21):8792-8801.
    • (2010) Cancer Res. , vol.70 , Issue.21 , pp. 8792-8801
    • Subramanyam, D.1    Belair, C.D.2    Barry-Holson, K.Q.3
  • 56
    • 13944269127 scopus 로고    scopus 로고
    • Interplay of RUNX1/MTG8 and DNA methyltransferase 1 in acute myeloid leukemia
    • Liu S, Shen T, Huynh L, et al. Interplay of RUNX1/MTG8 and DNA methyltransferase 1 in acute myeloid leukemia. Cancer Res. 2005; 65(4):1277-1284.
    • (2005) Cancer Res. , vol.65 , Issue.4 , pp. 1277-1284
    • Liu, S.1    Shen, T.2    Huynh, L.3
  • 57
    • 78650019179 scopus 로고    scopus 로고
    • Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation
    • Figueroa ME, Abdel-Wahab O, Lu C, et al. Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation. Cancer Cell. 2010;18(6):553-567.
    • (2010) Cancer Cell , vol.18 , Issue.6 , pp. 553-567
    • Figueroa, M.E.1    Abdel-Wahab, O.2    Lu, C.3
  • 58
    • 77649305610 scopus 로고    scopus 로고
    • The common feature of leukemia-Associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2- hydroxyglutarate
    • Ward PS, Patel J, Wise DR, et al. The common feature of leukemia-Associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2- hydroxyglutarate. Cancer Cell. 2010;17(3): 225-234.
    • (2010) Cancer Cell. , vol.17 , Issue.3 , pp. 225-234
    • Ward, P.S.1    Patel, J.2    Wise, D.R.3
  • 59
    • 84868208186 scopus 로고    scopus 로고
    • Recurrent somatic TET2 mutations in normal elderly individuals with clonal hematopoiesis
    • Busque L, Patel JP, Figueroa ME, et al. Recurrent somatic TET2 mutations in normal elderly individuals with clonal hematopoiesis. Nat Genet. 2012;44(11):1179-1181.
    • (2012) Nat Genet , vol.44 , Issue.11 , pp. 1179-1181
    • Busque, L.1    Patel, J.P.2    Figueroa, M.E.3
  • 60
    • 84915789576 scopus 로고    scopus 로고
    • DNA hydroxymethylation profiling reveals that WT1 mutations result in loss of TET2 function in acute myeloid leukemia
    • Rampal R, Alkalin A, Madzo J, et al. DNA hydroxymethylation profiling reveals that WT1 mutations result in loss of TET2 function in acute myeloid leukemia. Cell Reports. 2014;9(5): 1841-1855.
    • (2014) Cell Reports , vol.9 , Issue.5 , pp. 1841-1855
    • Rampal, R.1    Alkalin, A.2    Madzo, J.3
  • 61
    • 84928011690 scopus 로고    scopus 로고
    • Mutational cooperativity linked to combinatorial epigenetic gain of function in acute myeloid leukemia
    • Shih AH, Jiang Y, Meydan C, et al. Mutational cooperativity linked to combinatorial epigenetic gain of function in acute myeloid leukemia. Cancer Cell. 2015;27(4):502-515.
    • (2015) Cancer Cell , vol.27 , Issue.4 , pp. 502-515
    • Shih, A.H.1    Jiang, Y.2    Meydan, C.3
  • 62
    • 82955207588 scopus 로고    scopus 로고
    • Mechanisms and functions of Tet protein-mediated 5-methylcytosine oxidation
    • Wu H, Zhang Y. Mechanisms and functions of Tet protein-mediated 5-methylcytosine oxidation. Genes Dev. 2011;25(23):2436-2452.
    • (2011) Genes Dev. , vol.25 , Issue.23 , pp. 2436-2452
    • Wu, H.1    Zhang, Y.2
  • 63
    • 0035353203 scopus 로고    scopus 로고
    • The corepressor CtBP interacts with Evi- 1 to repress transforming growth factor beta signaling
    • Izutsu K, Kurokawa M, Imai Y, Maki K, Mitani K, Hirai H. The corepressor CtBP interacts with Evi- 1 to repress transforming growth factor beta signaling. Blood. 2001;97(9):2815-2822.
    • (2001) Blood , vol.97 , Issue.9 , pp. 2815-2822
    • Izutsu, K.1    Kurokawa, M.2    Imai, Y.3    Maki, K.4    Mitani, K.5    Hirai, H.6
  • 64
    • 85047695549 scopus 로고    scopus 로고
    • The leukemia-Associated transcription repressor AML1/MDS1/EVI1 requires CtBP to induce abnormal growth and differentiation of murine hematopoietic cells
    • Senyuk V, Chakraborty S, Mikhail FM, Zhao R, Chi Y, Nucifora G. The leukemia-Associated transcription repressor AML1/MDS1/EVI1 requires CtBP to induce abnormal growth and differentiation of murine hematopoietic cells. Oncogene. 2002;21(20):3232-3240.
    • (2002) Oncogene , vol.21 , Issue.20 , pp. 3232-3240
    • Senyuk, V.1    Chakraborty, S.2    Mikhail, F.M.3    Zhao, R.4    Chi, Y.5    Nucifora, G.6
  • 65
    • 31944434921 scopus 로고    scopus 로고
    • The methyl- CpG binding protein MBD1 is required for PMLRARalpha function
    • Villa R, Morey L, Raker VA, et al. The methyl- CpG binding protein MBD1 is required for PMLRARalpha function. Proc Natl Acad Sci USA. 2006;103(5):1400-1405.
    • (2006) Proc Natl Acad Sci USA , vol.103 , Issue.5 , pp. 1400-1405
    • Villa, R.1    Morey, L.2    Raker, V.A.3
  • 66
    • 84879341188 scopus 로고    scopus 로고
    • A dual role for Hdac1: Oncosuppressor in tumorigenesis, oncogene in tumor maintenance
    • Santoro F, Botrugno OA, Dal Zuffo R, et al. A dual role for Hdac1: oncosuppressor in tumorigenesis, oncogene in tumor maintenance. Blood. 2013;121(17):3459-3468.
    • (2013) Blood , vol.121 , Issue.17 , pp. 3459-3468
    • Santoro, F.1    Botrugno, O.A.2    Dal Zuffo, R.3
  • 67
    • 45749134591 scopus 로고    scopus 로고
    • Myeloid transforming protein Evi1 interacts with methyl-CpG binding domain protein 3 and inhibits in vitro histone deacetylation by Mbd3/Mi-2/NuRD
    • Spensberger D, Vermeulen M, Le Guezennec X, et al. Myeloid transforming protein Evi1 interacts with methyl-CpG binding domain protein 3 and inhibits in vitro histone deacetylation by Mbd3/Mi-2/NuRD. Biochemistry. 2008;47(24): 6418-6426.
    • (2008) Biochemistry , vol.47 , Issue.24 , pp. 6418-6426
    • Spensberger, D.1    Vermeulen, M.2    Le Guezennec, X.3
  • 68
    • 84862738480 scopus 로고    scopus 로고
    • BET domain co-regulators in obesity, inflammation and cancer
    • Belkina AC, Denis GV. BET domain co-regulators in obesity, inflammation and cancer. Nat Rev Cancer. 2012;12(7): 465-477.
    • (2012) Nat Rev Cancer , vol.12 , Issue.7 , pp. 465-477
    • Belkina, A.C.1    Denis, G.V.2
  • 69
    • 34250357662 scopus 로고    scopus 로고
    • The double bromodomaincontaining chromatin adaptor Brd4 and transcriptional regulation
    • Wu SY, Chiang CM. The double bromodomaincontaining chromatin adaptor Brd4 and transcriptional regulation. J Biol Chem. 2007; 282(18):13141-13145.
    • (2007) J Biol Chem , vol.282 , Issue.18 , pp. 13141-13145
    • Wu, S.Y.1    Chiang, C.M.2
  • 70
    • 80054984945 scopus 로고    scopus 로고
    • Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia
    • Dawson MA, Prinjha RK, Dittmann A, et al. Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia. Nature. 2011;478(7370):529-533.
    • (2011) Nature , vol.478 , Issue.7370 , pp. 529-533
    • Dawson, M.A.1    Prinjha, R.K.2    Dittmann, A.3
  • 71
    • 78650847770 scopus 로고    scopus 로고
    • Selective inhibition of BET bromodomains
    • Filippakopoulos P, Qi J, Picaud S, et al. Selective inhibition of BET bromodomains. Nature. 2010;468(7327):1067-1073.
    • (2010) Nature , vol.468 , Issue.7327 , pp. 1067-1073
    • Filippakopoulos, P.1    Qi, J.2    Picaud, S.3
  • 72
    • 78650806593 scopus 로고    scopus 로고
    • Suppression of inflammation by a synthetic histone mimic
    • Nicodeme E, Jeffrey KL, Schaefer U, et al. Suppression of inflammation by a synthetic histone mimic. Nature. 2010;468(7327): 1119-1123.
    • (2010) Nature , vol.468 , Issue.7327 , pp. 1119-1123
    • Nicodeme, E.1    Jeffrey, K.L.2    Schaefer, U.3
  • 73
    • 84897993655 scopus 로고    scopus 로고
    • BRD4: A BET(ter) target for the treatment of AML?
    • Valent P, Zuber J. BRD4: A BET(ter) target for the treatment of AML? Cell Cycle. 2014;13(5): 689-690.
    • (2014) Cell Cycle , vol.13 , Issue.5 , pp. 689-690
    • Valent, P.1    Zuber, J.2
  • 74
    • 84901821841 scopus 로고    scopus 로고
    • The mechanisms behind the therapeutic activity of BET bromodomain inhibition
    • Shi J, Vakoc CR. The mechanisms behind the therapeutic activity of BET bromodomain inhibition. Mol Cell. 2014;54(5):728-736.
    • (2014) Mol Cell , vol.54 , Issue.5 , pp. 728-736
    • Shi, J.1    Vakoc, C.R.2
  • 75
    • 84876222028 scopus 로고    scopus 로고
    • Selective inhibition of tumor oncogenes by disruption of super-enhancers
    • Loven J, Hoke HA, Lin CY, et al. Selective inhibition of tumor oncogenes by disruption of super-enhancers. Cell. 2013;153(2):320-334.
    • (2013) Cell , vol.153 , Issue.2 , pp. 320-334
    • Loven, J.1    Hoke, H.A.2    Lin, C.Y.3
  • 76
    • 84876216563 scopus 로고    scopus 로고
    • Master transcription factors and mediator establish super-enhancers at key cell identity genes
    • Whyte WA, Orlando DA, Hnisz D, et al. Master transcription factors and mediator establish super-enhancers at key cell identity genes. Cell. 2013;153(2):307-319.
    • (2013) Cell , vol.153 , Issue.2 , pp. 307-319
    • Whyte, W.A.1    Orlando, D.A.2    Hnisz, D.3
  • 77
    • 34249026300 scopus 로고    scopus 로고
    • Highresolution profiling of histone methylations in the human genome
    • Barski A, Cuddapah S, Cui K, et al. Highresolution profiling of histone methylations in the human genome. Cell. 2007;129(4):823-837.
    • (2007) Cell , vol.129 , Issue.4 , pp. 823-837
    • Barski, A.1    Cuddapah, S.2    Cui, K.3
  • 78
    • 79960044951 scopus 로고    scopus 로고
    • MLLrearranged leukemia is dependent on aberrant H3K79 methylation by DOT1L
    • Bernt KM, Zhu N, Sinha AU, et al. MLLrearranged leukemia is dependent on aberrant H3K79 methylation by DOT1L. Cancer Cell. 2011;20(1):66-78.
    • (2011) Cancer Cell , vol.20 , Issue.1 , pp. 66-78
    • Bernt, K.M.1    Zhu, N.2    Sinha, A.U.3
  • 79
    • 77955085750 scopus 로고    scopus 로고
    • Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders
    • Ernst T, Chase AJ, Score J, et al. Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders. Nat Genet. 2010; 42(8):722-726.
    • (2010) Nat Genet , vol.42 , Issue.8 , pp. 722-726
    • Ernst, T.1    Chase, A.J.2    Score, J.3
  • 80
    • 77955087290 scopus 로고    scopus 로고
    • Somatic mutations of the histone methyltransferase gene EZH2 in myelodysplastic syndromes
    • Nikoloski G, Langemeijer SM, Kuiper RP, et al. Somatic mutations of the histone methyltransferase gene EZH2 in myelodysplastic syndromes. Nat Genet. 2010;42(8):665-667.
    • (2010) Nat Genet , vol.42 , Issue.8 , pp. 665-667
    • Nikoloski, G.1    Langemeijer, S.M.2    Kuiper, R.P.3
  • 81
    • 84903178102 scopus 로고    scopus 로고
    • Ezh2 loss promotes development of myelodysplastic syndrome but attenuates its predisposition to leukaemic transformation
    • Sashida G, Harada H, Matsui H, et al. Ezh2 loss promotes development of myelodysplastic syndrome but attenuates its predisposition to leukaemic transformation. Nat Commun. 2014;5: 4177.
    • (2014) Nat Commun , vol.5 , pp. 4177
    • Sashida, G.1    Harada, H.2    Matsui, H.3
  • 82
    • 84859475727 scopus 로고    scopus 로고
    • Polycomb repressive complex 2 is required for MLL-AF9 leukemia
    • Neff T, Sinha AU, Kluk MJ, et al. Polycomb repressive complex 2 is required for MLL-AF9 leukemia. Proc Natl Acad Sci USA. 2012; 109(13):5028-5033.
    • (2012) Proc Natl Acad Sci USA. , vol.109 , Issue.13 , pp. 5028-5033
    • Neff, T.1    Sinha, A.U.2    Kluk, M.J.3
  • 83
    • 84923366733 scopus 로고    scopus 로고
    • Chromatin architecture reorganization during stem cell differentiation
    • Dixon JR, Jung I, Selvaraj S, et al. Chromatin architecture reorganization during stem cell differentiation. Nature. 2015;518(7539): 331-336.
    • (2015) Nature , vol.518 , Issue.7539 , pp. 331-336
    • Dixon, J.R.1    Jung, I.2    Selvaraj, S.3
  • 84
    • 34247560765 scopus 로고    scopus 로고
    • Kimura A expression of polycombgroup. Expression of Polycomb-group (PcG) protein BMI-1 predicts prognosis in patients with acute myeloid leukemia
    • Chowdhury M, Mihara K, Yasunaga S, Ohtaki M, Takihara Y, Kimura A Expression of Polycombgroup. Expression of Polycomb-group (PcG) protein BMI-1 predicts prognosis in patients with acute myeloid leukemia. Leukemia. 2007;21(5): 1116-1122.
    • (2007) Leukemia , vol.21 , Issue.5 , pp. 1116-1122
    • Chowdhury, M.1    Mihara, K.2    Yasunaga, S.3    Ohtaki, M.4    Takihara, Y.5
  • 85
    • 30144443995 scopus 로고    scopus 로고
    • Bmi-1 is useful as a novel molecular marker for predicting progression of myelodysplastic syndrome and patient prognosis
    • Mihara K, Chowdhury M, Nakaju N, et al. Bmi-1 is useful as a novel molecular marker for predicting progression of myelodysplastic syndrome and patient prognosis. Blood. 2006; 107(1):305-308.
    • (2006) Blood , vol.107 , Issue.1 , pp. 305-308
    • Mihara, K.1    Chowdhury, M.2    Nakaju, N.3
  • 86
    • 34249869559 scopus 로고    scopus 로고
    • Role of the polycomb repressive complex 2 in acute promyelocytic leukemia
    • Villa R, Pasini D, Gutierrez A, et al. Role of the polycomb repressive complex 2 in acute promyelocytic leukemia. Cancer Cell. 2007; 11(6):513-525.
    • (2007) Cancer Cell , vol.11 , Issue.6 , pp. 513-525
    • Villa, R.1    Pasini, D.2    Gutierrez, A.3
  • 87
    • 66149154321 scopus 로고    scopus 로고
    • The PRC1 Polycomb group complex interacts with PLZF/RARA to mediate leukemic transformation
    • Boukarabila H, Saurin AJ, Batsche E, et al. The PRC1 Polycomb group complex interacts with PLZF/RARA to mediate leukemic transformation. Genes Dev. 2009;23(10):1195-1206.
    • (2009) Genes Dev , vol.23 , Issue.10 , pp. 1195-1206
    • Boukarabila, H.1    Saurin, A.J.2    Batsche, E.3
  • 88
    • 11144332565 scopus 로고    scopus 로고
    • Histone demethylation mediated by the nuclear amine oxidase homolog LSD1
    • Shi Y, Lan F, Matson C, et al. Histone demethylation mediated by the nuclear amine oxidase homolog LSD1. Cell. 2004;119(7): 941-953.
    • (2004) Cell , vol.119 , Issue.7 , pp. 941-953
    • Shi, Y.1    Lan, F.2    Matson, C.3
  • 89
    • 84869009858 scopus 로고    scopus 로고
    • An Inv(16)(p13.3q24.3)-encoded CBFA2T3-GLIS2 fusion protein defines an aggressive subtype of pediatric acute megakaryoblastic leukemia
    • Gruber TA, Larson Gedman A, Zhang J, et al. An Inv(16)(p13.3q24.3)-encoded CBFA2T3-GLIS2 fusion protein defines an aggressive subtype of pediatric acute megakaryoblastic leukemia. Cancer Cell. 2012;22(5):683-697.
    • (2012) Cancer Cell , vol.22 , Issue.5 , pp. 683-697
    • Gruber, T.A.1    Larson, G.A.2    Zhang, J.3
  • 90
  • 91
    • 84871712509 scopus 로고    scopus 로고
    • Protein arginine methyltransferases and cancer
    • Yang Y, Bedford MT. Protein arginine methyltransferases and cancer. Nat Rev Cancer. 2013;13(1):37-50.
    • (2013) Nat Rev Cancer , vol.13 , Issue.1 , pp. 37-50
    • Yang, Y.1    Bedford, M.T.2
  • 92
    • 84941657778 scopus 로고    scopus 로고
    • Arginine methyltransferase PRMT5 is essential for sustaining normal adult hematopoiesis
    • Liu F, Cheng G, Hamard PJ, et al. Arginine methyltransferase PRMT5 is essential for sustaining normal adult hematopoiesis. J Clin Invest. 2015;125(9):3532-3544.
    • (2015) J Clin, Invest , vol.125 , Issue.9 , pp. 3532-3544
    • Liu, F.1    Cheng, G.2    Hamard, P.J.3
  • 93
    • 70349975711 scopus 로고    scopus 로고
    • JAK2 phosphorylates histone H3Y41 and excludes HP1alpha from chromatin
    • Dawson MA, Bannister AJ, Gottgens B, et al. JAK2 phosphorylates histone H3Y41 and excludes HP1alpha from chromatin. Nature. 2009;461(7265):819-822.
    • (2009) Nature , vol.461 , Issue.7265 , pp. 819-822
    • Dawson, M.A.1    Bannister, A.J.2    Gottgens, B.3
  • 94
    • 84940600974 scopus 로고    scopus 로고
    • Safety and tolerability of guadecitabine (SGI-110) in patients with myelodysplastic syndrome and acute myeloid leukaemia: A multicentre, randomised, dose-escalation phase 1 study
    • Issa JP, Roboz G, Rizzieri D, et al. Safety and tolerability of guadecitabine (SGI-110) in patients with myelodysplastic syndrome and acute myeloid leukaemia: A multicentre, randomised, dose-escalation phase 1 study. Lancet Oncol. 2015;16(9):1099-1110.
    • (2015) Lancet Oncol , vol.16 , Issue.9 , pp. 1099-1110
    • Issa, J.P.1    Roboz, G.2    Rizzieri, D.3
  • 95
    • 84923786336 scopus 로고    scopus 로고
    • Identifying novel selective non-nucleoside DNA methyltransferase 1 inhibitors through docking-based virtual screening
    • Chen S, Wang Y, Zhou W, et al. Identifying novel selective non-nucleoside DNA methyltransferase 1 inhibitors through docking-based virtual screening. J Med Chem. 2014;57(21):9028-9041.
    • (2014) J Med Chem , vol.57 , Issue.21 , pp. 9028-9041
    • Chen, S.1    Wang, Y.2    Zhou, W.3
  • 96
    • 84899625247 scopus 로고    scopus 로고
    • Smallmolecule inhibition of CBP/catenin interactions eliminates drug-resistant clones in acute lymphoblastic leukemia
    • Gang EJ, Hsieh YT, Pham J, et al. Smallmolecule inhibition of CBP/catenin interactions eliminates drug-resistant clones in acute lymphoblastic leukemia. Oncogene. 2014; 33(17):2169-2178.
    • (2014) Oncogene , vol.33 , Issue.17 , pp. 2169-2178
    • Gang, E.J.1    Hsieh, Y.T.2    Pham, J.3
  • 97
    • 84873504145 scopus 로고    scopus 로고
    • A histone acetyltransferase p300 inhibitor C646 induces cell cycle arrest and apoptosis selectively in AML1-ETO-positive AML cells
    • Gao XN, Lin J, Ning QY, et al. A histone acetyltransferase p300 inhibitor C646 induces cell cycle arrest and apoptosis selectively in AML1-ETO-positive AML cells. PLoS One. 2013; 8(2):e55481.
    • (2013) PLoS One , vol.8 , Issue.2 , pp. e55481
    • Gao, X.N.1    Lin, J.2    Ning, Q.Y.3
  • 98
    • 84867632489 scopus 로고    scopus 로고
    • A selective inhibitor of EZH2 blocks H3K27 methylation and kills mutant lymphoma cells
    • Knutson SK, Wigle TJ, Warholic NM, et al. A selective inhibitor of EZH2 blocks H3K27 methylation and kills mutant lymphoma cells. Nat Chem Biol. 2012;8(11):890-896.
    • (2012) Nat Chem Biol , vol.8 , Issue.11 , pp. 890-896
    • Knutson, S.K.1    Wigle, T.J.2    Warholic, N.M.3
  • 99
    • 84901354460 scopus 로고    scopus 로고
    • 3-Deazaneplanocin A (DZNep), an inhibitor of the histone methyltransferase EZH2, induces apoptosis and reduces cell migration in chondrosarcoma, cells
    • Girard N, Bazille C, Lhuissier E, et al. 3-Deazaneplanocin A (DZNep), an inhibitor of the histone methyltransferase EZH2, induces apoptosis and reduces cell migration in chondrosarcoma cells. PLoS One. 2014;9(5): E98176.
    • (2014) PLoS One , vol.9 , Issue.5 , pp. e98176
    • Girard, N.1    Bazille, C.2    Lhuissier, E.3
  • 100
    • 84857195696 scopus 로고    scopus 로고
    • Menin-MLL inhibitors reverse oncogenic activity of MLL fusion proteins in leukemia
    • Grembecka J, He S, Shi A, et al. Menin-MLL inhibitors reverse oncogenic activity of MLL fusion proteins in leukemia. Nat Chem Biol. 2012;8(3):277-284.
    • (2012) Nat Chem Biol , vol.8 , Issue.3 , pp. 277-284
    • Grembecka, J.1    He, S.2    Shi, A.3
  • 101
    • 84907482290 scopus 로고    scopus 로고
    • Validation and structural characterization of the LEDGF/p75-MLL interface as a new target for the treatment of MLL-dependent leukemia
    • Cermakova K, Tesina P, Demeulemeester J, et al. Validation and structural characterization of the LEDGF/p75-MLL interface as a new target for the treatment of MLL-dependent leukemia. Cancer Res. 2014; 74(18):5139-5151.
    • (2014) Cancer Res , vol.74 , Issue.18 , pp. 5139-5151
    • Cermakova, K.1    Tesina, P.2    Demeulemeester, J.3
  • 102
    • 84875987260 scopus 로고    scopus 로고
    • Identification of small molecule inhibitors of Jumonji AT-rich interactive domain 1B (JARID1B) histone demethylase by a sensitive high throughput screen
    • Sayegh J, Cao J, Zou MR, et al. Identification of small molecule inhibitors of Jumonji AT-rich interactive domain 1B (JARID1B) histone demethylase by a sensitive high throughput screen. J Biol Chem. 2013;288(13): 9408-9417.
    • (2013) J Biol Chem , vol.288 , Issue.13 , pp. 9408-9417
    • Sayegh, J.1    Cao, J.2    Zou, M.R.3
  • 103
    • 84865120905 scopus 로고    scopus 로고
    • A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response
    • Kruidenier L, Chung CW, Cheng Z, et al. A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response. Nature. 2012;488(7411):404-408.
    • (2012) Nature , vol.488 , Issue.7411 , pp. 404-408
    • Kruidenier, L.1    Chung, C.W.2    Cheng, Z.3
  • 104
    • 84937397052 scopus 로고    scopus 로고
    • A selective inhibitor of PRMT5 with in vivo and in vitro potency in MCL models
    • Chan-Penebre E, Kuplast KG, Majer CR, et al. A selective inhibitor of PRMT5 with in vivo and in vitro potency in MCL models. Nat Chem Biol. 2015;11(6):432-437.
    • (2015) Nat Chem Biol. , vol.11 , Issue.6 , pp. 432-437
    • Chan-Penebre, E.1    Kuplast, K.G.2    Majer, C.R.3
  • 105
    • 84927747737 scopus 로고    scopus 로고
    • Selective inhibition of protein arginine methyltransferase 5 blocks initiation and maintenance of B-cell transformation
    • Alinari L, Mahasenan KV, Yan F, et al. Selective inhibition of protein arginine methyltransferase 5 blocks initiation and maintenance of B-cell transformation. Blood. 2015;125(16):2530-2543.
    • (2015) Blood , vol.125 , Issue.16 , pp. 2530-2543
    • Alinari, L.1    Mahasenan, K.V.2    Yan, F.3
  • 106
  • 107
    • 84937780839 scopus 로고    scopus 로고
    • Azacitidine in AML: A treatment option?
    • Huls G. Azacitidine in AML: A treatment option? Blood. 2015;126(3):283-284.
    • (2015) Blood , vol.126 , Issue.3 , pp. 283-284
    • Huls, G.1
  • 108
    • 84937804118 scopus 로고    scopus 로고
    • International phase 3 study of azacitidine vs conventional care regimens in older patients with newly diagnosed AML with. 30% blasts
    • Dombret H, Seymour JF, Butrym A, et al. International phase 3 study of azacitidine vs conventional care regimens in older patients with newly diagnosed AML with .30% blasts. Blood. 2015;126(3):291-299.
    • (2015) Blood , vol.126 , Issue.3 , pp. 291-299
    • Dombret, H.1    Seymour, J.F.2    Butrym, A.3
  • 109
    • 77952140672 scopus 로고    scopus 로고
    • Clinical response and miR-29b predictive significance in older AML patients treated with a 10-day schedule of decitabine
    • Blum W, Garzon R, Klisovic RB, et al. Clinical response and miR-29b predictive significance in older AML patients treated with a 10-day schedule of decitabine. Proc Natl Acad Sci USA. 2010;107(16):7473-7478.
    • (2010) Proc Natl Acad Sci USA , vol.107 , Issue.16 , pp. 7473-7478
    • Blum, W.1    Garzon, R.2    Klisovic, R.B.3
  • 110
    • 84929069698 scopus 로고    scopus 로고
    • Decitabine reduces transfusion dependence in older patients with acute myeloid leukemia: Results from a post hoc analysis of a randomized phase III study
    • He J, Xiu L, De Porre P, Dass R, Thomas X. Decitabine reduces transfusion dependence in older patients with acute myeloid leukemia: results from a post hoc analysis of a randomized phase III study. Leuk Lymphoma. 2015;56(4): 1033-1042.
    • (2015) Leuk Lymphoma , vol.56 , Issue.4 , pp. 1033-1042
    • He, J.1    Xiu, L.2    De Porre, P.3    Dass, R.4    Thomas, X.5
  • 111
    • 78650172030 scopus 로고    scopus 로고
    • Groupe Francophone des Myelodysplasies(GFM). Prognostic factors for response and overall survival in 282 patients with higher-risk myelodysplastic syndromes treated with azacitidine
    • Itzykson R, Thepot S, Quesnel B, et al; Groupe Francophone des Myelodysplasies(GFM). Prognostic factors for response and overall survival in 282 patients with higher-risk myelodysplastic syndromes treated with azacitidine. Blood. 2011;117(2):403-411.
    • (2011) Blood , vol.117 , Issue.2 , pp. 403-411
    • Itzykson, R.1    Thepot, S.2    Quesnel, B.3
  • 112
    • 84928982643 scopus 로고    scopus 로고
    • Specific molecular signatures predict decitabine response in chronic myelomonocytic leukemia
    • Meldi K, Qin T, Buchi F, et al. Specific molecular signatures predict decitabine response in chronic myelomonocytic leukemia. J Clin Invest. 2015;125(5):1857-1872.
    • (2015) J Clin Invest. , vol.125 , Issue.5 , pp. 1857-1872
    • Meldi, K.1    Qin, T.2    Buchi, F.3
  • 113
    • 84891876933 scopus 로고    scopus 로고
    • Impact of molecular mutations on treatment response to DNMT inhibitors in myelodysplasia and related neoplasms
    • Traina F, Visconte V, Elson P, et al. Impact of molecular mutations on treatment response to DNMT inhibitors in myelodysplasia and related neoplasms. Leukemia. 2014;28(1): 78-87.
    • (2014) Leukemia , vol.28 , Issue.1 , pp. 78-87
    • Traina, F.1    Visconte, V.2    Elson, P.3
  • 114
    • 79960229916 scopus 로고    scopus 로고
    • Groupe Francophone des Myelodysplasies (GFM). Impact of TET2 mutations on response rate to azacitidine in myelodysplastic syndromes and low blast count acute myeloid leukemias
    • Itzykson R, Kosmider O, Cluzeau T, et al; Groupe Francophone des Myelodysplasies (GFM). Impact of TET2 mutations on response rate to azacitidine in myelodysplastic syndromes and low blast count acute myeloid leukemias. Leukemia. 2011;25(7):1147-1152.
    • (2011) Leukemia , vol.25 , Issue.7 , pp. 1147-1152
    • Itzykson, R.1    Kosmider, O.2    Cluzeau, T.3
  • 115
    • 84930932850 scopus 로고    scopus 로고
    • AG-221, an oral, selective, first-in-class, potent inhibitor of the IDH2 mutant metabolic enzyme, induces durable remissions in a phase I study in patients with IDH2 mutation positive advanced hematologic malignancies
    • Stein EM, Altman JK, Collins R, et al. AG-221, an oral, selective, first-in-class, potent inhibitor of the IDH2 mutant metabolic enzyme, induces durable remissions in a phase I study in patients with IDH2 mutation positive advanced hematologic malignancies. Blood. 2014;124(21): 115-115.
    • (2014) Blood , vol.124 , Issue.21 , pp. 115
    • Stein, E.M.1    Altman, J.K.2    Collins, R.3
  • 116
    • 84877620952 scopus 로고    scopus 로고
    • Targeted inhibition of mutant IDH2 in leukemia cells induces cellular differentiation
    • Wang F, Travins J, DeLaBarre B, et al. Targeted inhibition of mutant IDH2 in leukemia cells induces cellular differentiation. Science. 2013; 340(6132):622-626.
    • (2013) Science , vol.340 , Issue.6132 , pp. 622-626
    • Wang, F.1    Travins, J.2    DeLaBarre, B.3
  • 117
    • 84922652321 scopus 로고    scopus 로고
    • Isocitrate dehydrogenase 1 and 2 mutations induce BCL-2 dependence in acute myeloid leukemia
    • Chan SM, Thomas D, Corces-Zimmerman MR, et al. Isocitrate dehydrogenase 1 and 2 mutations induce BCL-2 dependence in acute myeloid leukemia. Nat Med. 2015;21(2): 178-184.
    • (2015) Nat Med. , vol.21 , Issue.2 , pp. 178-184
    • Chan, S.M.1    Thomas, D.2    Corces-Zimmerman, M.R.3
  • 118
    • 84906557615 scopus 로고    scopus 로고
    • A vaccine targeting mutant IDH1 induces antitumour immunity
    • Schumacher T, Bunse L, Pusch S, et al. A vaccine targeting mutant IDH1 induces antitumour immunity. Nature. 2014;512(7514): 324-327.
    • (2014) Nature , vol.512 , Issue.7514 , pp. 324-327
    • Schumacher, T.1    Bunse, L.2    Pusch, S.3
  • 119
    • 79952262759 scopus 로고    scopus 로고
    • Histone deacetylase (HDAC) inhibitors in recent clinical trials for cancer therapy
    • Wagner JM, Hackanson B, Lubbert M, Jung M. Histone deacetylase (HDAC) inhibitors in recent clinical trials for cancer therapy. Clin Epigenetics. 2010;1(3-4):117-136.
    • (2010) Clin Epigenetics , vol.1 , Issue.3-4 , pp. 117-136
    • Wagner, J.M.1    Hackanson, B.2    Lubbert, M.3    Jung, M.4
  • 120
    • 79751528245 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors for the treatment of myelodysplastic syndrome and acute myeloid leukemia
    • Quintas-Cardama A, Santos FP, Garcia-Manero G. Histone deacetylase inhibitors for the treatment of myelodysplastic syndrome and acute myeloid leukemia. Leukemia. 2011;25(2): 226-235.
    • (2011) Leukemia , vol.25 , Issue.2 , pp. 226-235
    • Quintas-Cardama, A.1    Santos, F.P.2    Garcia-Manero, G.3
  • 121
    • 84864011031 scopus 로고    scopus 로고
    • Phase II trial of vorinostat with idarubicin and cytarabine for patients with newly diagnosed acute myelogenous leukemia or myelodysplastic syndrome
    • Garcia-Manero G, Tambaro FP, Bekele NB, et al. Phase II trial of vorinostat with idarubicin and cytarabine for patients with newly diagnosed acute myelogenous leukemia or myelodysplastic syndrome. J Clin Oncol. 2012;30(18): 2204-2210.
    • (2012) J Clin Oncol , vol.30 , Issue.18 , pp. 2204-2210
    • Garcia-Manero, G.1    Tambaro, F.P.2    Bekele, N.B.3
  • 122
    • 84922553345 scopus 로고    scopus 로고
    • Combining DNA methyltransferase and histone deacetylase inhibition to treat acute myeloid leukemia/myelodysplastic syndrome: Achievements and challenges
    • Lubbert M, Kuendgen A. Combining DNA methyltransferase and histone deacetylase inhibition to treat acute myeloid leukemia/myelodysplastic syndrome: Achievements and challenges. Cancer. 2015;121(4): 498-501.
    • (2015) Cancer , vol.121 , Issue.4 , pp. 498-501
    • Lubbert, M.1    Kuendgen, A.2
  • 123
    • 84908555755 scopus 로고    scopus 로고
    • A phase 1 clinical trial of vorinostat in combination with decitabine in patients with acute myeloid leukaemia or myelodysplastic syndrome
    • Kirschbaum M, Gojo I, Goldberg SL, et al. A phase 1 clinical trial of vorinostat in combination with decitabine in patients with acute myeloid leukaemia or myelodysplastic syndrome. Br J Haematol. 2014;167(2): 185-193.
    • (2014) Br J Haematol , vol.167 , Issue.2 , pp. 185-193
    • Kirschbaum, M.1    Gojo, I.2    Goldberg, S.L.3
  • 124
    • 84925345011 scopus 로고    scopus 로고
    • Phase I/II trial of the combination of midostaurin (PKC412) and 5-Azacytidine for patients with acute myeloid leukemia and myelodysplastic syndrome
    • Strati P, Kantarjian H, Ravandi F, et al. Phase I/II trial of the combination of midostaurin (PKC412) and 5-Azacytidine for patients with acute myeloid leukemia and myelodysplastic syndrome. Am J Hematol. 2015;90(4):276-281.
    • (2015) Am J Hematol , vol.90 , Issue.4 , pp. 276-281
    • Strati, P.1    Kantarjian, H.2    Ravandi, F.3
  • 125
    • 84922513553 scopus 로고    scopus 로고
    • Results of phase 2 randomized study of lowdose decitabine with or without valproic acid in patients with myelodysplastic syndrome and acute myelogenous leukemia
    • Issa JP, Garcia-Manero G, Huang X, et al. Results of phase 2 randomized study of lowdose decitabine with or without valproic acid in patients with myelodysplastic syndrome and acute myelogenous leukemia. Cancer. 2015; 121(4):556-561.
    • (2015) Cancer , vol.121 , Issue.4 , pp. 556-561
    • Issa, J.P.1    Garcia-Manero, G.2    Huang, X.3
  • 126
    • 84904066247 scopus 로고    scopus 로고
    • Prolonged administration of azacitidine with or without entinostat for myelodysplastic syndrome and acute myeloid leukemia with myelodysplasiarelated changes: Results of the US Leukemia Intergroup trial E1905
    • Prebet T, Sun Z, Figueroa ME, et al. Prolonged administration of azacitidine with or without entinostat for myelodysplastic syndrome and acute myeloid leukemia with myelodysplasiarelated changes: results of the US Leukemia Intergroup trial E1905. J Clin Oncol. 2014; 32(12):1242-1248.
    • (2014) J Clin Oncol , vol.32 , Issue.12 , pp. 1242-1248
    • Prebet, T.1    Sun, Z.2    Figueroa, M.E.3
  • 127
    • 80055000824 scopus 로고    scopus 로고
    • RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia
    • Zuber J, Shi J, Wang E, et al. RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia. Nature. 2011;478(7370): 524-528.
    • (2011) Nature , vol.478 , Issue.7370 , pp. 524-528
    • Zuber, J.1    Shi, J.2    Wang, E.3
  • 128
    • 84874720284 scopus 로고    scopus 로고
    • Small-molecule inhibition of BRD4 as a new potent approach to eliminate leukemic stem- And progenitor cells in acute myeloid leukemia AML
    • Herrmann H, Blatt K, Shi J, et al. Small-molecule inhibition of BRD4 as a new potent approach to eliminate leukemic stem- And progenitor cells in acute myeloid leukemia AML. Oncotarget. 2012;3(12):1588-1599.
    • (2012) Oncotarget , vol.3 , Issue.12 , pp. 1588-1599
    • Herrmann, H.1    Blatt, K.2    Shi, J.3
  • 129
    • 84893735484 scopus 로고    scopus 로고
    • Recurrent mutations, including NPM1c, activate a BRD4-dependent core transcriptional program in acute myeloid leukemia
    • Dawson MA, Gudgin EJ, Horton SJ, et al. Recurrent mutations, including NPM1c, activate a BRD4-dependent core transcriptional program in acute myeloid leukemia. Leukemia. 2014; 28(2):311-320.
    • (2014) Leukemia , vol.28 , Issue.2 , pp. 311-320
    • Dawson, M.A.1    Gudgin, E.J.2    Horton, S.J.3
  • 130
    • 84966527823 scopus 로고    scopus 로고
    • A phase 1 study of the BET-bromodomain inhibitor OTX015 in patients with advanced acute leukemia
    • Dombret H, Preudhomme C, Berthon C, et al. A phase 1 study of the BET-bromodomain inhibitor OTX015 in patients with advanced acute leukemia. Blood. 2014;124(21): 117-117.
    • (2014) Blood , vol.124 , Issue.21 , pp. 117
    • Dombret, H.1    Preudhomme, C.2    Berthon, C.3
  • 131
    • 84932634729 scopus 로고    scopus 로고
    • Phthalimide conjugation as a strategy for in vivo target protein degradation
    • Winter GE, Buckley DL, Paulk J, et al. Phthalimide conjugation as a strategy for in vivo target protein degradation. Science. 2015;348(6241): 1376-1381.
    • (2015) Science , vol.348 , Issue.6241 , pp. 1376-1381
    • Winter, G.E.1    Buckley, D.L.2    Paulk, J.3
  • 133
    • 84859867217 scopus 로고    scopus 로고
    • Breaking the LSD1/KDM1A addiction: Therapeutic targeting of the epigenetic modifier in AML
    • Lokken AA, Zeleznik-Le NJ. Breaking the LSD1/KDM1A addiction: Therapeutic targeting of the epigenetic modifier in AML. Cancer Cell. 2012; 21(4):451-453.
    • (2012) Cancer Cell , vol.21 , Issue.4 , pp. 451-453
    • Lokken, A.A.1    Zeleznik-Le, N.J.2
  • 134
    • 84862777766 scopus 로고    scopus 로고
    • Inhibition of the LSD1 (KDM1A) demethylase reactivates the all-trans-retinoic acid differentiation pathway in acute myeloid leukemia
    • Schenk T, Chen WC, Gollner S, et al. Inhibition of the LSD1 (KDM1A) demethylase reactivates the all-trans-retinoic acid differentiation pathway in acute myeloid leukemia. Nat Med. 2012;18(4):605-611.
    • (2012) Nat Med , vol.18 , Issue.4 , pp. 605-611
    • Schenk, T.1    Chen, W.C.2    Gollner, S.3
  • 135
    • 79960058024 scopus 로고    scopus 로고
    • Selective killing of mixed lineage leukemia cells by a potent small-molecule DOT1L inhibitor
    • Daigle SR, Olhava EJ, Therkelsen CA, et al. Selective killing of mixed lineage leukemia cells by a potent small-molecule DOT1L inhibitor. Cancer Cell. 2011;20(1):53-65.
    • (2011) Cancer Cell , vol.20 , Issue.1 , pp. 53-65
    • Daigle, S.R.1    Olhava, E.J.2    Therkelsen, C.A.3
  • 136
    • 80052955256 scopus 로고    scopus 로고
    • BET bromodomain inhibition as a therapeutic strategy to target c-Myc
    • Delmore JE, Issa GC, Lemieux ME, et al. BET bromodomain inhibition as a therapeutic strategy to target c-Myc. Cell. 2011;146(6): 904-917.
    • (2011) Cell , vol.146 , Issue.6 , pp. 904-917
    • Delmore, J.E.1    Issa, G.C.2    Lemieux, M.E.3
  • 137
    • 84928013058 scopus 로고    scopus 로고
    • Current challenges in clinical development of "targeted therapies": The case of acute myeloid leukemia
    • Estey E, Levine RL, Lowenberg B. Current challenges in clinical development of "targeted therapies": The case of acute myeloid leukemia. Blood. 2015;125(16): 2461-2466.
    • (2015) Blood , vol.125 , Issue.16 , pp. 2461-2466
    • Estey, E.1    Levine, R.L.2    Lowenberg, B.3
  • 139
    • 84896081834 scopus 로고    scopus 로고
    • Functional heterogeneity of genetically defined subclones in acute myeloid leukemia
    • Klco JM, Spencer DH, Miller CA, et al. Functional heterogeneity of genetically defined subclones in acute myeloid leukemia. Cancer Cell. 2014;25(3):379-392.
    • (2014) Cancer Cell. , vol.25 , Issue.3 , pp. 379-392
    • Klco, J.M.1    Spencer, D.H.2    Miller, C.A.3
  • 140
    • 84925518008 scopus 로고    scopus 로고
    • Role of TP53 mutations in the origin and evolution of therapy-related acute myeloid leukaemia
    • Wong TN, Ramsingh G, Young AL, et al. Role of TP53 mutations in the origin and evolution of therapy-related acute myeloid leukaemia. Nature. 2015;518(7540):552-555.
    • (2015) Nature , vol.518 , Issue.7540 , pp. 552-555
    • Wong, T.N.1    Ramsingh, G.2    Young, A.L.3


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