Identifying novel selective non-nucleoside DNA methyltransferase 1 inhibitors through docking-based virtual screening

Journal of Medicinal Chemistry

Volumn 57, Issue 21, 2014, Pages 9028-9041

  Chen, Shijie ^a   Wang, Yulan ^a   Zhou, Wen ^d   Li, Shanshan ^b   Peng, Jianlong ^a   Shi, Zhe ^c   Hu, Junchi ^a   Liu, Yu Chih ^c   Ding, Hong ^a   Lin, Yijyun ^c   Li, Linjuan ^a,e   Cheng, Sufang ^a   Liu, Jingqiu ^a   Lu, Tao ^b   Jiang, Hualiang ^a,e   Liu, Bo ^d   Zheng, Mingyue ^a   Luo, Cheng ^a  

^a SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

^b CHINA PHARMACEUTICAL UNIVERSITY   (China)

^c Shanghai ChemPartner Co Ltd   (China)

^d GUANGDONG PROVINCIAL HOSPITAL OF CHINESE MEDICINE   (China)

^e SHANGHAITECH UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

1 [[1,3 DI (9H CARBAZOL 9 YL)PROPAN 2 YL]OXY] 3 (ISOPROPYLAMINO)PROPAN 2 OL; 1 [[2 (1H INDOL 3 YL)ETHYL]AMINO] 3 (9H CARBAZOL 9 YL)PROPAN 2 OL; 9 (OXIRAN 2 YLMETHYL) 9H CARBAZOLE; 9 (OXIRAN 2 YLMETHYL) 9H CARBAZOLYL; 9,9' [2 (OXIRAN 2 YLMETHOXY)PROPANE 1,3 DIYL]BIS(9H CARBAZOLE); ANTINEOPLASTIC AGENT; DNA METHYLTRANSFERASE 1; DNA METHYLTRANSFERASE INHIBITOR; NUCLEOSIDE ANALOG; UNCLASSIFIED DRUG; [2 (OXIRAN 2 YLMETHOXY)PROPANE 1,3 DIYL]BIS(9H CARBAZOLE); DNA (CYTOSINE 5) METHYLTRANSFERASE; DNA (CYTOSINE-5-)-METHYLTRANSFERASE 1; ENZYME INHIBITOR;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL; CELL PROLIFERATION; CONTROLLED STUDY; DNA METHYLATION; DRUG BINDING; DRUG SCREENING; DRUG SELECTIVITY; DRUG STRUCTURE; HUMAN; HUMAN CELL; IC50; MOLECULAR DOCKING; ANTAGONISTS AND INHIBITORS; DRUG EFFECTS; GENETIC EPIGENESIS; STRUCTURE ACTIVITY RELATION; SYNTHESIS; TUMOR CELL LINE;

CELL LINE, TUMOR; CELL PROLIFERATION; DNA (CYTOSINE-5-)-METHYLTRANSFERASE; DNA METHYLATION; ENZYME INHIBITORS; EPIGENESIS, GENETIC; HUMANS; INHIBITORY CONCENTRATION 50; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84923786336     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm501134e     Document Type: Article

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