Identification of small molecule inhibitors of Jumonji AT-rich interactive domain 1B (JARID1B) histone demethylase by a sensitive high throughput screen

Journal of Biological Chemistry

Volumn 288, Issue 13, 2013, Pages 9408-9417

  Sayegh, Joyce ^a   Cao, Jian ^a   Zou, Mike Ran ^a   Morales, Alfonso ^a   Blair, Lauren P ^a   Norcia, Michael ^b   Hoyer, Denton ^b   Tackett, Alan J ^c   Merkel, Jane S ^b   Yan, Qin ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b YALE UNIVERSITY   (United States)

^c UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4-METHYLPHENYL; CANCER THERAPY; HIGH-THROUGHPUT SCREENS; INTERACTIVE DOMAINS; MAMMARY TUMORS; PROSTATE CANCERS; SMALL MOLECULE INHIBITOR; SMALL MOLECULES;

AMINO ACIDS; DISEASES; LEAD COMPOUNDS; ONCOLOGY; THROUGHPUT;

MOLECULES;

2 (4 METHYLPHENYL) 1,2 BENZISOTHIAZOL 3(2H) ONE; 2,4 PYRIDINEDICARBOXYLIC ACID; CAFFEIC ACID; CATECHOL; EBSELEN; ENZYME INHIBITOR; ESCULETIN; HISTONE DEMETHYLASE; JUMONJI AT RICH INTERACTIVE DOMAIN 1B; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; DRUG STRUCTURE; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME INHIBITION; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; LUMINESCENCE; MOLECULAR LIBRARY; MOUSE; NONHUMAN; PRIORITY JOURNAL; SENSITIVITY ANALYSIS; STRUCTURE ANALYSIS; VALIDATION PROCESS;

ANIMALS; ANTINEOPLASTIC AGENTS; CELL LINE; CELL LINE, TUMOR; CELL PROLIFERATION; CHEMISTRY, PHARMACEUTICAL; DRUG DESIGN; EPIGENESIS, GENETIC; HIGH-THROUGHPUT SCREENING ASSAYS; HISTONE DEMETHYLASES; HISTONES; HUMANS; INSECTS; JUMONJI DOMAIN-CONTAINING HISTONE DEMETHYLASES; NEOPLASMS; NUCLEAR PROTEINS; PEPTIDES; PROTEIN BINDING; RECOMBINANT PROTEINS; REPRESSOR PROTEINS; THIAZOLES;

EID: 84875987260     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.419861     Document Type: Article

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