-
1
-
-
84896714827
-
Safety and efficacy of vemurafenib in BRAF (V600E) and BRAF(V600K) mutation-positive melanoma (BRIM-3): Extended follow-up of a phase 3, randomised, open-label study
-
McArthur GA, Chapman PB, Robert C, et al. Safety and efficacy of vemurafenib in BRAF (V600E) and BRAF(V600K) mutation-positive melanoma (BRIM-3): extended follow-up of a phase 3, randomised, open-label study. Lancet Oncol. 2014;15(3):323-332.
-
(2014)
Lancet Oncol
, vol.15
, Issue.3
, pp. 323-332
-
-
McArthur, G.A.1
Chapman, P.B.2
Robert, C.3
-
2
-
-
84911908120
-
Trastuzumab plus adjuvant chemotherapy for human epidermal growth factor receptor 2-positive breast cancer: Planned joint analysis of overall survival from NSABP B-31 and NCCTG N9831
-
Perez EA, Romond EH, Suman VJ, et al. Trastuzumab plus adjuvant chemotherapy for human epidermal growth factor receptor 2-positive breast cancer: planned joint analysis of overall survival from NSABP B-31 and NCCTG N9831. J Clin Oncol. 2014;32(33):3744-3752.
-
(2014)
J Clin Oncol
, vol.32
, Issue.33
, pp. 3744-3752
-
-
Perez, E.A.1
Romond, E.H.2
Suman, V.J.3
-
3
-
-
84918804764
-
First-line crizotinib versus chemotherapy in ALK-positive lung cancer
-
Solomon BJ, Mok T, Kim D-W, et al PROFILE 1014 Investigators. First-line crizotinib versus chemotherapy in ALK-positive lung cancer. N Engl J Med. 2014;371(23):2167-2177.
-
(2014)
N Engl J Med
, vol.371
, Issue.23
, pp. 2167-2177
-
-
Solomon, B.J.1
Mok, T.2
Kim, D.-W.3
-
4
-
-
84918791506
-
Cancer-drug discovery-let's get ready for the next period
-
Longo DL. Cancer-drug discovery-let's get ready for the next period. N Engl J Med. 2014;371(23):2227-2228.
-
(2014)
N Engl J Med
, vol.371
, Issue.23
, pp. 2227-2228
-
-
Longo, D.L.1
-
5
-
-
84889647348
-
New agents: Great expectations not realized
-
Lancet JE. New agents: great expectations not realized. Best Pract Res Clin Haematol. 2013;26(3):269-274.
-
(2013)
Best Pract Res Clin Haematol
, vol.26
, Issue.3
, pp. 269-274
-
-
Lancet, J.E.1
-
6
-
-
0037818705
-
New designs for phase 2 clinical trials
-
Estey EH, Thall PF. New designs for phase 2 clinical trials. Blood. 2003;102(2):442-448.
-
(2003)
Blood
, vol.102
, Issue.2
, pp. 442-448
-
-
Estey, E.H.1
Thall, P.F.2
-
7
-
-
80052420105
-
Applicability of a "Pick a Winner" trial design to acute myeloid leukemia
-
Hills RK, Burnett AK. Applicability of a "Pick a Winner" trial design to acute myeloid leukemia. Blood. 2011;118(9):2389-2394.
-
(2011)
Blood
, vol.118
, Issue.9
, pp. 2389-2394
-
-
Hills, R.K.1
Burnett, A.K.2
-
8
-
-
84878372012
-
Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia
-
Cancer Genome Atlas Research Network. Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia. N Engl J Med. 2013;368(22):2059-2074.
-
(2013)
N Engl J Med
, vol.368
, Issue.22
, pp. 2059-2074
-
-
Cancer Genome Atlas Research Network1
-
9
-
-
84864255882
-
The origin and evolution of mutations in acute myeloid leukemia
-
Welch JS, Ley TJ, Link DC, et al. The origin and evolution of mutations in acute myeloid leukemia. Cell. 2012;150(2):264-278.
-
(2012)
Cell
, vol.150
, Issue.2
, pp. 264-278
-
-
Welch, J.S.1
Ley, T.J.2
Link, D.C.3
-
10
-
-
84896081834
-
Functional heterogeneity of genetically defined subclones in acute myeloid leukemia
-
Klco JM, Spencer DH, Miller CA, et al. Functional heterogeneity of genetically defined subclones in acute myeloid leukemia. Cancer Cell. 2014;25(3):379-392.
-
(2014)
Cancer Cell
, vol.25
, Issue.3
, pp. 379-392
-
-
Klco, J.M.1
Spencer, D.H.2
Miller, C.A.3
-
12
-
-
84883730914
-
Clonal evolution in relapsed NPM1-mutated acute myeloid leukemia
-
Krönke J, Bullinger L, Teleanu V, et al. Clonal evolution in relapsed NPM1-mutated acute myeloid leukemia. Blood. 2013;122(1):100-108.
-
(2013)
Blood
, vol.122
, Issue.1
, pp. 100-108
-
-
Krönke, J.1
Bullinger, L.2
Teleanu, V.3
-
13
-
-
74049121331
-
Contribution of bone microenvironment to leukemogenesis and leukemia progression
-
Ayala F, Dewar R, Kieran M, Kalluri R. Contribution of bone microenvironment to leukemogenesis and leukemia progression. Leukemia. 2009;23(12):2233-2241.
-
(2009)
Leukemia
, vol.23
, Issue.12
, pp. 2233-2241
-
-
Ayala, F.1
Dewar, R.2
Kieran, M.3
Kalluri, R.4
-
14
-
-
0022344945
-
Stimulation of proliferation and differentiation of acute myeloid leukemia cells on a bone marrow stroma in culture
-
Schölzel C, Löwenberg B. Stimulation of proliferation and differentiation of acute myeloid leukemia cells on a bone marrow stroma in culture. Exp Hematol. 1985;13(7):664-669.
-
(1985)
Exp Hematol
, vol.13
, Issue.7
, pp. 664-669
-
-
Schölzel, C.1
Löwenberg, B.2
-
15
-
-
84925883902
-
Ex vivo assays to study selfrenewal, long-term expansion, and leukemic transformation of genetically modified human hematopoietic and patient-derived leukemic stem cells
-
Sontakke P, Carretta M, Capala M, Schepers H, Schuringa JJ. Ex vivo assays to study selfrenewal, long-term expansion, and leukemic transformation of genetically modified human hematopoietic and patient-derived leukemic stem cells. Methods Mol Biol. 2014;1185:195-210.
-
(2014)
Methods Mol Biol
, vol.1185
, pp. 195-210
-
-
Sontakke, P.1
Carretta, M.2
Capala, M.3
Schepers, H.4
Schuringa, J.J.5
-
16
-
-
84883742684
-
Epigenetics in clinical practice: The examples of azacitidine and decitabine in myelodysplasia and acute myeloid leukemia
-
Estey EH. Epigenetics in clinical practice: the examples of azacitidine and decitabine in myelodysplasia and acute myeloid leukemia. Leukemia. 2013;27(9):1803-1812.
-
(2013)
Leukemia
, vol.27
, Issue.9
, pp. 1803-1812
-
-
Estey, E.H.1
-
17
-
-
84911944457
-
Antioxidant N-acetyl-L-cysteine increases engraftment of human hematopoietic stem cells in immune-deficient mice
-
Hu L, Cheng H, Gao Y, et al. Antioxidant N-acetyl-L-cysteine increases engraftment of human hematopoietic stem cells in immune-deficient mice. Blood. 2014;124(20):e45-e48.
-
(2014)
Blood
, vol.124
, Issue.20
, pp. e45-e48
-
-
Hu, L.1
Cheng, H.2
Gao, Y.3
-
18
-
-
77958013367
-
AML xenograft efficiency is significantly improved in NOD/SCID-IL2RG mice constitutively expressing human SCF, GM-CSF and IL-3
-
Wunderlich M, Chou FS, Link KA, et al. AML xenograft efficiency is significantly improved in NOD/SCID-IL2RG mice constitutively expressing human SCF, GM-CSF and IL-3. Leukemia. 2010;24(10):1785-1788.
-
(2010)
Leukemia
, vol.24
, Issue.10
, pp. 1785-1788
-
-
Wunderlich, M.1
Chou, F.S.2
Link, K.A.3
-
19
-
-
84877930065
-
AML cells are differentially sensitive to chemotherapy treatment in a human xenograft model
-
Wunderlich M, Mizukawa B, Chou FS, et al. AML cells are differentially sensitive to chemotherapy treatment in a human xenograft model. Blood. 2013;121(12):e90-e97.
-
(2013)
Blood
, vol.121
, Issue.12
, pp. e90-e97
-
-
Wunderlich, M.1
Mizukawa, B.2
Chou, F.S.3
-
20
-
-
84890040482
-
Individualized systems medicine strategy to tailor treatments for patients with chemorefractory acute myeloid leukemia
-
Pemovska T, Kontro M, Yadav B, et al. Individualized systems medicine strategy to tailor treatments for patients with chemorefractory acute myeloid leukemia. Cancer Discov. 2013;3(12):1416-1429.
-
(2013)
Cancer Discov
, vol.3
, Issue.12
, pp. 1416-1429
-
-
Pemovska, T.1
Kontro, M.2
Yadav, B.3
-
21
-
-
84891404742
-
Organoid cultures for the analysis of cancer phenotypes
-
Sachs N, Clevers H. Organoid cultures for the analysis of cancer phenotypes. Curr Opin Genet Dev. 2014;24:68-73.
-
(2014)
Curr Opin Genet Dev
, vol.24
, pp. 68-73
-
-
Sachs, N.1
Clevers, H.2
-
22
-
-
84920983131
-
Organoid models of human and mouse ductal pancreatic cancer
-
Boj SF, Hwang C-I, Baker LA, et al. Organoid models of human and mouse ductal pancreatic cancer. Cell. 2015;160(1-2):324-338.
-
(2015)
Cell
, vol.160
, Issue.1-2
, pp. 324-338
-
-
Boj, S.F.1
Hwang, C.-I.2
Baker, L.A.3
-
23
-
-
84875752966
-
Modeling colorectal cancer as a 3-dimensional disease in a dish: The case for drug screening using organoids, zebrafish, and fruit flies
-
Markstein M. Modeling colorectal cancer as a 3-dimensional disease in a dish: the case for drug screening using organoids, zebrafish, and fruit flies. Drug Discov Today Technol. 2013;10(1):e73-e81.
-
(2013)
Drug Discov Today Technol
, vol.10
, Issue.1
, pp. e73-e81
-
-
Markstein, M.1
-
24
-
-
84907494553
-
Quantitative optical imaging of primary tumor organoid metabolism predicts drug response in breast cancer
-
Walsh AJ, Cook RS, Sanders ME, et al. Quantitative optical imaging of primary tumor organoid metabolism predicts drug response in breast cancer. Cancer Res. 2014;74(18):5184-5194.
-
(2014)
Cancer Res
, vol.74
, Issue.18
, pp. 5184-5194
-
-
Walsh, A.J.1
Cook, R.S.2
Sanders, M.E.3
-
25
-
-
84903461580
-
Potential mechanisms of disease progression and management of advanced-phase chronic myeloid leukemia
-
Jabbour EJ, Hughes TP, Cortés JE, Kantarjian HM, Hochhaus A. Potential mechanisms of disease progression and management of advanced-phase chronic myeloid leukemia. Leuk Lymphoma. 2014;55(7):1451-1462.
-
(2014)
Leuk Lymphoma
, vol.55
, Issue.7
, pp. 1451-1462
-
-
Jabbour, E.J.1
Hughes, T.P.2
Cortés, J.E.3
Kantarjian, H.M.4
Hochhaus, A.5
-
26
-
-
0037093092
-
Imatinib induces hematologic and cytogenetic responses in patients with chronic myelogenous leukemia in myeloid blast crisis: Results of a phase II study
-
Sawyers CL, Hochhaus A, Feldman E, et al. Imatinib induces hematologic and cytogenetic responses in patients with chronic myelogenous leukemia in myeloid blast crisis: results of a phase II study. Blood. 2002;99(10):3530-3539.
-
(2002)
Blood
, vol.99
, Issue.10
, pp. 3530-3539
-
-
Sawyers, C.L.1
Hochhaus, A.2
Feldman, E.3
-
27
-
-
84860785167
-
Nilotinib is effective in imatinib-resistant or -intolerant patients with chronic myeloid leukemia in blastic phase
-
Giles FJ, Kantarjian HM, le Coutre PD, et al. Nilotinib is effective in imatinib-resistant or -intolerant patients with chronic myeloid leukemia in blastic phase. Leukemia. 2012;26(5):959-962.
-
(2012)
Leukemia
, vol.26
, Issue.5
, pp. 959-962
-
-
Giles, F.J.1
Kantarjian, H.M.2
Le Coutre, P.D.3
-
28
-
-
57849159300
-
Efficacy and safety of dasatinib in imatinib-resistant or -intolerant patients with chronic myeloid leukemia in blast phase
-
Cortes J, Kim DW, Raffoux E, et al. Efficacy and safety of dasatinib in imatinib-resistant or -intolerant patients with chronic myeloid leukemia in blast phase. Leukemia. 2008;22(12):2176-2183.
-
(2008)
Leukemia
, vol.22
, Issue.12
, pp. 2176-2183
-
-
Cortes, J.1
Kim, D.W.2
Raffoux, E.3
-
29
-
-
84887127701
-
A phase 2 trial of ponatinib in Philadelphia chromosome-positive leukemias
-
Cortes JE, Kim DW, Pinilla-Ibarz J, et al PACE Investigators. A phase 2 trial of ponatinib in Philadelphia chromosome-positive leukemias. N Engl J Med. 2013;369(19):1783-1796.
-
(2013)
N Engl J Med
, vol.369
, Issue.19
, pp. 1783-1796
-
-
Cortes, J.E.1
Kim, D.W.2
Pinilla-Ibarz, J.3
-
30
-
-
85027936063
-
Allogeneic hematopoietic SCT in combination with tyrosine kinase inhibitor treatment compared with TKI treatment alone in CML blast crisis
-
Jiang H, Xu LP, Liu DH, et al. Allogeneic hematopoietic SCT in combination with tyrosine kinase inhibitor treatment compared with TKI treatment alone in CML blast crisis. Bone Marrow Transplant. 2014;49(9):1146-1154.
-
(2014)
Bone Marrow Transplant
, vol.49
, Issue.9
, pp. 1146-1154
-
-
Jiang, H.1
Xu, L.P.2
Liu, D.H.3
-
31
-
-
0027517243
-
Resistance to all-trans retinoic acid (ATRA) therapy in relapsing acute promyelocytic leukemia: Study of in vitro ATRA sensitivity and cellular retinoic acid binding protein levels in leukemic cells
-
Delva L, Cornic M, Balitrand N, et al. Resistance to all-trans retinoic acid (ATRA) therapy in relapsing acute promyelocytic leukemia: study of in vitro ATRA sensitivity and cellular retinoic acid binding protein levels in leukemic cells. Blood. 1993;82(7):2175-2181.
-
(1993)
Blood
, vol.82
, Issue.7
, pp. 2175-2181
-
-
Delva, L.1
Cornic, M.2
Balitrand, N.3
-
32
-
-
0033215452
-
Molecular remissions induced by liposomal-encapsulated all-trans retinoic acid in newly diagnosed acute promyelocytic leukemia
-
Estey EH, Giles FJ, Kantarjian H, et al. Molecular remissions induced by liposomal-encapsulated all-trans retinoic acid in newly diagnosed acute promyelocytic leukemia. Blood. 1999;94(7):2230-2235.
-
(1999)
Blood
, vol.94
, Issue.7
, pp. 2230-2235
-
-
Estey, E.H.1
Giles, F.J.2
Kantarjian, H.3
-
33
-
-
0033890197
-
Long-term follow-up confirms the benefit of all-trans retinoic acid in acute promyelocytic leukemia
-
Fenaux P, Chevret S, Guerci A, et al; European APL group. Long-term follow-up confirms the benefit of all-trans retinoic acid in acute promyelocytic leukemia. Leukemia. 2000;14(8):1371-1377.
-
(2000)
Leukemia
, vol.14
, Issue.8
, pp. 1371-1377
-
-
Fenaux, P.1
Chevret, S.2
Guerci, A.3
-
34
-
-
84880287051
-
Retinoic acid and arsenic trioxide for acute promyelocytic leukemia
-
Lo-Coco F, Avvisati G, Vignetti M, et al; Gruppo Italiano Malattie Ematologiche dell'Adulto; German-Austrian Acute Myeloid Leukemia Study Group; Study Alliance Leukemia. Retinoic acid and arsenic trioxide for acute promyelocytic leukemia. N Engl J Med. 2013;369(2):111-121.
-
(2013)
N Engl J Med
, vol.369
, Issue.2
, pp. 111-121
-
-
Lo-Coco, F.1
Avvisati, G.2
Vignetti, M.3
-
35
-
-
84928021559
-
ABL001, a potent allosteric inhibitor of BCR-ABL, prevents emergence of resistant disease when administered in combination with nilotinib in an in vivo murine model of chronic myeloid leukemia
-
abstract
-
Wylie A, Schoepfer J, Berellini G, et al. ABL001, a potent allosteric inhibitor of BCR-ABL, prevents emergence of resistant disease when administered in combination with nilotinib in an in vivo murine model of chronic myeloid leukemia [abstract]. Blood. 2014;124(21). Abstract 398.
-
(2014)
Blood
, vol.124
, Issue.21
-
-
Wylie, A.1
Schoepfer, J.2
Berellini, G.3
-
36
-
-
84930932850
-
AG-221, an oral, selective, first-in-class, potent inhibitor of the IDH2 mutant metabolic enzyme, induces durable remissions in a phase 1 study in patients with IDH2 mutation positive advanced hematologic malignancies
-
abstract
-
Stein EM, Altman JK, Collins R, et al. AG-221, an oral, selective, first-in-class, potent inhibitor of the IDH2 mutant metabolic enzyme, induces durable remissions in a phase 1 study in patients with IDH2 mutation positive advanced hematologic malignancies [abstract]. Blood. 2014;124(21). Abstract 115.
-
(2014)
Blood
, vol.124
, Issue.21
-
-
Stein, E.M.1
Altman, J.K.2
Collins, R.3
-
37
-
-
84922652321
-
Isocitrate dehydrogenase 1 and 2 mutations induce BCL-2 dependence in acute myeloid leukemia
-
Chan SM, Thomas D, Corces-Zimmerman MR, et al. Isocitrate dehydrogenase 1 and 2 mutations induce BCL-2 dependence in acute myeloid leukemia. Nat Med. 2015;21(2):178-184.
-
(2015)
Nat Med
, vol.21
, Issue.2
, pp. 178-184
-
-
Chan, S.M.1
Thomas, D.2
Corces-Zimmerman, M.R.3
-
38
-
-
84964731300
-
Phase 1/1b study of RG7388, a potent MDM2 antagonist, in acute myelogenous leukemia (AML) patients (Pts)
-
abstract
-
Yee K, Martinelli G, Vey N, et al. Phase 1/1b study of RG7388, a potent MDM2 antagonist, in acute myelogenous leukemia (AML) patients (Pts) [abstract]. Blood. 2014;124(21). Abstract 116.
-
(2014)
Blood
, vol.124
, Issue.21
-
-
Yee, K.1
Martinelli, G.2
Vey, N.3
-
40
-
-
84928021556
-
-
Available at Accessed January 25, 2015
-
Réseau Onco-Normand. F50067 in 101 Pierre FABRE. Available at: http://reseau-onconormand.org/en/hematologie/leucemie/640-f50067-in-101-pierre-fabre. Accessed January 25, 2015.
-
F50067 in 101 Pierre FABRE
-
-
-
41
-
-
78650242755
-
Bayesian models and decision algorithms for complex early phase clinical trials
-
Thall PF. Bayesian models and decision algorithms for complex early phase clinical trials. Stat Sci. 2010;25(2):227-244.
-
(2010)
Stat Sci
, vol.25
, Issue.2
, pp. 227-244
-
-
Thall, P.F.1
-
42
-
-
23044510049
-
New paradigm in dose-finding trials: Patient-specific dosing and beyond phase I
-
Rogatko A, Babb JS, Tighiouart M, Khuri FR, Hudes G. New paradigm in dose-finding trials: patient-specific dosing and beyond phase I. Clin Cancer Res. 2005;11(15):5342-5346.
-
(2005)
Clin Cancer Res
, vol.11
, Issue.15
, pp. 5342-5346
-
-
Rogatko, A.1
Babb, J.S.2
Tighiouart, M.3
Khuri, F.R.4
Hudes, G.5
-
43
-
-
54349092877
-
Monosomal karyotype in acute myeloid leukemia: A better indicator of poor prognosis than a complex karyotype
-
Breems DA, Van Putten WL, De Greef GE, et al. Monosomal karyotype in acute myeloid leukemia: a better indicator of poor prognosis than a complex karyotype. J Clin Oncol. 2008;26(29):4791-4797.
-
(2008)
J Clin Oncol
, vol.26
, Issue.29
, pp. 4791-4797
-
-
Breems, D.A.1
Van Putten, W.L.2
De Greef, G.E.3
-
44
-
-
84863952219
-
Comparative analysis of the value of allogeneic hematopoietic stem-cell transplantation in acute myeloid leukemia with monosomal karyotype versus other cytogenetic risk categories
-
Cornelissen JJ, Breems D, van Putten WL, et al. Comparative analysis of the value of allogeneic hematopoietic stem-cell transplantation in acute myeloid leukemia with monosomal karyotype versus other cytogenetic risk categories. J Clin Oncol. 2012;30(17):2140-2146.
-
(2012)
J Clin Oncol
, vol.30
, Issue.17
, pp. 2140-2146
-
-
Cornelissen, J.J.1
Breems, D.2
Van Putten, W.L.3
-
45
-
-
84857734093
-
TP53 alterations in acute myeloid leukemia with complex karyotype correlate with specific copy number alterations, monosomal karyotype, and dismal outcome
-
Rücker FG, Schlenk RF, Bullinger L, et al. TP53 alterations in acute myeloid leukemia with complex karyotype correlate with specific copy number alterations, monosomal karyotype, and dismal outcome. Blood. 2012;119(9):2114-2121.
-
(2012)
Blood
, vol.119
, Issue.9
, pp. 2114-2121
-
-
Rücker, F.G.1
Schlenk, R.F.2
Bullinger, L.3
-
46
-
-
41949090673
-
The impact of FLT3 internal tandem duplication mutant level, number, size, and interaction with NPM1 mutations in a large cohort of young adult patients with acute myeloid leukemia
-
Gale RE, Green C, Allen C, et al Medical Research Council Adult Leukaemia Working Party. The impact of FLT3 internal tandem duplication mutant level, number, size, and interaction with NPM1 mutations in a large cohort of young adult patients with acute myeloid leukemia. Blood. 2008;111(5):2776-2784.
-
(2008)
Blood
, vol.111
, Issue.5
, pp. 2776-2784
-
-
Gale, R.E.1
Green, C.2
Allen, C.3
-
47
-
-
84893788771
-
Declining rates of treatment-related mortality in patients with newly diagnosed AML given 'intense' induction regimens: A report from SWOG and MD Anderson
-
Othus M, Kantarjian H, Petersdorf S, et al. Declining rates of treatment-related mortality in patients with newly diagnosed AML given 'intense' induction regimens: a report from SWOG and MD Anderson. Leukemia. 2014;28(2):289-292.
-
(2014)
Leukemia
, vol.28
, Issue.2
, pp. 289-292
-
-
Othus, M.1
Kantarjian, H.2
Petersdorf, S.3
-
48
-
-
84864029167
-
Cracking open window of opportunity trials
-
Kalinsky K, Hershman DL. Cracking open window of opportunity trials. J Clin Oncol. 2012;30(21):2573-2575.
-
(2012)
J Clin Oncol
, vol.30
, Issue.21
, pp. 2573-2575
-
-
Kalinsky, K.1
Hershman, D.L.2
-
49
-
-
84927127471
-
Relation of clinical response and minimal residual disease and their prognostic impact on outcome in acute myeloid leukemia
-
published online ahead of print March 2
-
Chen X, Xie H, Wood BL, et al. Relation of clinical response and minimal residual disease and their prognostic impact on outcome in acute myeloid leukemia [published online ahead of print March 2, 2015]. J Clin Oncol.
-
(2015)
J Clin Oncol
-
-
Chen, X.1
Xie, H.2
Wood, B.L.3
-
50
-
-
84920692361
-
Comparison of minimal residual disease as outcome predictor for AML patients in first complete remission undergoing myeloablative or nonmyeloablative allogeneic hematopoietic cell transplantation
-
Walter RB, Gyurkocza B, Storer BE, et al. Comparison of minimal residual disease as outcome predictor for AML patients in first complete remission undergoing myeloablative or nonmyeloablative allogeneic hematopoietic cell transplantation. Leukemia. 2015;29(1):137-144.
-
(2015)
Leukemia
, vol.29
, Issue.1
, pp. 137-144
-
-
Walter, R.B.1
Gyurkocza, B.2
Storer, B.E.3
-
51
-
-
77956404446
-
Nonmyeloablative allogeneic hematopoietic cell transplantation in patients with acute myeloid leukemia
-
Gyurkocza B, Storb R, Storer BE, et al. Nonmyeloablative allogeneic hematopoietic cell transplantation in patients with acute myeloid leukemia. J Clin Oncol. 2010;28(17):2859-2867.
-
(2010)
J Clin Oncol
, vol.28
, Issue.17
, pp. 2859-2867
-
-
Gyurkocza, B.1
Storb, R.2
Storer, B.E.3
-
52
-
-
84869856060
-
A phase 1 trial of the anti-inhibitory KIR mAb IPH2101 for AML in complete remission
-
Vey N, Bourhis J-H, Boissel N, et al. A phase 1 trial of the anti-inhibitory KIR mAb IPH2101 for AML in complete remission. Blood. 2012;120(22):4317-4323.
-
(2012)
Blood
, vol.120
, Issue.22
, pp. 4317-4323
-
-
Vey, N.1
Bourhis, J.-H.2
Boissel, N.3
-
53
-
-
33745714215
-
Improved leukemia-free survival after postconsolidation immunotherapy with histamine dihydrochloride and interleukin-2 in acute myeloid leukemia: Results of a randomized phase 3 trial
-
Brune M, Castaigne S, Catalano J, et al. Improved leukemia-free survival after postconsolidation immunotherapy with histamine dihydrochloride and interleukin-2 in acute myeloid leukemia: results of a randomized phase 3 trial. Blood. 2006;108(1):88-96.
-
(2006)
Blood
, vol.108
, Issue.1
, pp. 88-96
-
-
Brune, M.1
Castaigne, S.2
Catalano, J.3
-
54
-
-
84923222497
-
The DOT1L inhibitor EPZ-5676: Safety and activity in relapsed/refractory patients with MLL-rearranged leukemia
-
abstract
-
Stein EM, Garcia-Manero G, Rizzieri DA, et al. The DOT1L inhibitor EPZ-5676: safety and activity in relapsed/refractory patients with MLL-rearranged leukemia [abstract]. Blood. 2014; 124(21). Abstract 387.
-
(2014)
Blood
, vol.124
, Issue.21
-
-
Stein, E.M.1
Garcia-Manero, G.2
Rizzieri, D.A.3
-
55
-
-
84880991913
-
'Basket studies' will hold intricate data for cancer drug approvals
-
Willyard C. 'Basket studies' will hold intricate data for cancer drug approvals. Nat Med. 2013;19(6):655.
-
(2013)
Nat Med
, vol.19
, Issue.6
, pp. 655
-
-
Willyard, C.1
-
56
-
-
84892621038
-
Efficacy of vemurafenib in hairy-cell leukemia
-
Samuel J, Macip S, Dyer MJ. Efficacy of vemurafenib in hairy-cell leukemia. N Engl J Med. 2014;370(3):286-288.
-
(2014)
N Engl J Med
, vol.370
, Issue.3
, pp. 286-288
-
-
Samuel, J.1
Macip, S.2
Dyer, M.J.3
-
57
-
-
33744513575
-
Sorafenib (BAY 43-9006, Nexavar), a dual-action inhibitor that targets RAF/MEK/ERK pathway in tumor cells and tyrosine kinases VEGFR/PDGFR in tumor vasculature
-
Adnane L, Trail PA, Taylor I, Wilhelm SM. Sorafenib (BAY 43-9006, Nexavar), a dual-action inhibitor that targets RAF/MEK/ERK pathway in tumor cells and tyrosine kinases VEGFR/PDGFR in tumor vasculature. Methods Enzymol. 2006;407:597-612.
-
(2006)
Methods Enzymol
, vol.407
, pp. 597-612
-
-
Adnane, L.1
Trail, P.A.2
Taylor, I.3
Wilhelm, S.M.4
-
58
-
-
84928021555
-
Sorafenib versus placebo in addition to standard therapy in younger patients with newly diagnosed acute myeloid leukemia: Results from 267 patients treated in the randomized placebo-controlled SAL-Soraml trial
-
abstract
-
Röllig C, Müller-Tidow C, Hüttmann A, et al. Sorafenib versus placebo in addition to standard therapy in younger patients with newly diagnosed acute myeloid leukemia: results from 267 patients treated in the randomized placebo-controlled SAL-Soraml trial [abstract]. Blood. 2014;124(21). Abstract 6.
-
(2014)
Blood
, vol.124
, Issue.21
-
-
Röllig, C.1
Müller-Tidow, C.2
Hüttmann, A.3
-
59
-
-
84875592100
-
Final results of a phase 2 open-label, monotherapy efficacy and safety study of quizartinib (AC220) in patients ≥ 60 years of age with FLT3 ITD positive or negative relapsed/refractory acute myeloid leukemia
-
abstract
-
Cortes JE, Perl AE, Dombret H, et al. Final results of a phase 2 open-label, monotherapy efficacy and safety study of quizartinib (AC220) in patients ≥ 60 years of age with FLT3 ITD positive or negative relapsed/refractory acute myeloid leukemia [abstract]. Blood. 2012;120(21). Abstract 48.
-
(2012)
Blood
, vol.120
, Issue.21
-
-
Cortes, J.E.1
Perl, A.E.2
Dombret, H.3
-
60
-
-
84928021554
-
Adding KIT inhibitor dasatinib (DAS) to chemotherapy overcomes the negative impact of KIT mutation/over-expression in core binding factor (CBF) acute myeloid leukemia (AML): Results from CALGB 10801 (Alliance)
-
abstract
-
Marcucci G, Geyer S, Zhao W, et al. Adding KIT inhibitor dasatinib (DAS) to chemotherapy overcomes the negative impact of KIT mutation/over-expression in core binding factor (CBF) acute myeloid leukemia (AML): results from CALGB 10801 (Alliance) [abstract]. Blood. 2014;124(21). Abstract 8.
-
(2014)
Blood
, vol.124
, Issue.21
-
-
Marcucci, G.1
Geyer, S.2
Zhao, W.3
-
61
-
-
84903583539
-
Results of a phase 2 randomized, open-label, study of lower doses of quizartinib (AC220; ASP2689) in subjects with FLT3-ITD positive relapsed or refractory acute myeloid leukemia (AML)
-
abstract
-
Cortes JE, Tallman MS, Schiller G, et al. Results of a phase 2 randomized, open-label, study of lower doses of quizartinib (AC220; ASP2689) in subjects with FLT3-ITD positive relapsed or refractory acute myeloid leukemia (AML) [abstract]. Blood. 2013;122(21). Abstract 494.
-
(2013)
Blood
, vol.122
, Issue.21
-
-
Cortes, J.E.1
Tallman, M.S.2
Schiller, G.3
-
62
-
-
1542753559
-
Revised recommendations of the International Working Group for Diagnosis, Standardization of Response Criteria, Treatment Outcomes, and Reporting Standards for Therapeutic Trials in Acute Myeloid Leukemia
-
published correction appears in J Clin Oncol. 2004;22(3):576
-
Cheson BD, Bennett JM, Kopecky KJ, et al International Working Group for Diagnosis, Standardization of Response Criteria, Treatment Outcomes, and Reporting Standards for Therapeutic Trials in Acute Myeloid Leukemia. Revised recommendations of the International Working Group for Diagnosis, Standardization of Response Criteria, Treatment Outcomes, and Reporting Standards for Therapeutic Trials in Acute Myeloid Leukemia [published correction appears in J Clin Oncol. 2004;22(3):576]. J Clin Oncol. 2003;21(24):4642-4649.
-
(2003)
J Clin Oncol
, vol.21
, Issue.24
, pp. 4642-4649
-
-
Cheson, B.D.1
Bennett, J.M.2
Kopecky, K.J.3
-
63
-
-
84873409057
-
The addition of gemtuzumab ozogamicin to low-dose Ara-C improves remission rate but does not significantly prolong survival in older patients with acute myeloid leukaemia: Results from the LRF AML14 and NCRI AML16 pick-a-winner comparison
-
Burnett AK, Hills RK, Hunter AE, et al UK National Cancer Research Institute AML Working Group. The addition of gemtuzumab ozogamicin to low-dose Ara-C improves remission rate but does not significantly prolong survival in older patients with acute myeloid leukaemia: results from the LRF AML14 and NCRI AML16 pick-a-winner comparison. Leukemia. 2013;27(1):75-81.
-
(2013)
Leukemia
, vol.27
, Issue.1
, pp. 75-81
-
-
Burnett, A.K.1
Hills, R.K.2
Hunter, A.E.3
-
64
-
-
84886859143
-
Clofarabine doubles the response rate in older patients with acute myeloid leukemia but does not improve survival
-
Burnett AK, Russell NH, Hunter AE, et al UK National Cancer Research Institute AML Working Group. Clofarabine doubles the response rate in older patients with acute myeloid leukemia but does not improve survival. Blood. 2013;122(8):1384-1394.
-
(2013)
Blood
, vol.122
, Issue.8
, pp. 1384-1394
-
-
Burnett, A.K.1
Russell, N.H.2
Hunter, A.E.3
-
65
-
-
84894459968
-
Importance of achieving stringent complete response after autologous stem-cell transplantation in multiple myeloma
-
Kapoor P, Kumar SK, Dispenzieri A, et al. Importance of achieving stringent complete response after autologous stem-cell transplantation in multiple myeloma. J Clin Oncol. 2013;31(36):4529-4535.
-
(2013)
J Clin Oncol
, vol.31
, Issue.36
, pp. 4529-4535
-
-
Kapoor, P.1
Kumar, S.K.2
Dispenzieri, A.3
-
66
-
-
84928021553
-
An evaluation of molecular response in a phase 2 open-label, multicenter confirmatory study in patients (pts) with relapsed/refractory B-precursor acute lymphoblastic leukemia (r/r ALL) receiving treatment with the BiTE antibody construct blinatumomab
-
abstract
-
Goekbuget N, Kantarjian HM, Brüggemann M, et al. An evaluation of molecular response in a phase 2 open-label, multicenter confirmatory study in patients (pts) with relapsed/refractory B-precursor acute lymphoblastic leukemia (r/r ALL) receiving treatment with the BiTE antibody construct blinatumomab [abstract]. Blood. 2014;124(21). Abstract 3704.
-
(2014)
Blood
, vol.124
, Issue.21
-
-
Goekbuget, N.1
Kantarjian, H.M.2
Brüggemann, M.3
-
67
-
-
84928021552
-
Results of the ECOG E1900 trial in younger adults with AML using an event free survival endpoint are concordant with results based on overall survival: Potential for a surrogate endpoint to facilitate rapid approval of therapies in AML
-
abstract
-
Luskin MR, Lee J-W, Fernandez HF, et al. Results of the ECOG E1900 trial in younger adults with AML using an event free survival endpoint are concordant with results based on overall survival: potential for a surrogate endpoint to facilitate rapid approval of therapies in AML [abstract]. Blood. 2014;124(21). Abstract 2599.
-
(2014)
Blood
, vol.124
, Issue.21
-
-
Luskin, M.R.1
Lee, J.-W.2
Fernandez, H.F.3
-
68
-
-
84928021551
-
FDA approves Opdivo for advanced melanoma
-
December 22, 2014. Available at Accessed December 28, 2014
-
U.S. Food and Drug Administration. FDA approves Opdivo for advanced melanoma. FDA News Release, December 22, 2014. Available at: http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm427716.htm. Accessed December 28, 2014.
-
FDA News Release
-
-
-
69
-
-
84928021550
-
FDA approves Zykadia for late-stage lung cancer
-
April 29,2014. Available at Accessed December 28, 2014
-
U.S. Food and Drug Administration. FDA approves Zykadia for late-stage lung cancer. FDA News Release, April 29,2014. Available at: http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm395299.htm. Accessed December 28, 2014.
-
FDA News Release
-
-
|