Hematopoiesis and stem cells: Enforced differentiation of Dnmt3a-null bone marrow leads to failure with c-Kit mutations driving leukemic transformation

Blood

Volumn 125, Issue 4, 2015, Pages 619-628

  Celik, Hamza ^a   Mallaney, Cates ^a   Kothari, Alok ^a   Ostrander, Elizabeth L ^a   Eultgen, Elizabeth ^a   Martens, Andrew ^a   Miller, Christopher A ^a   Hundal, Jasreet ^a   Klco, Jeffery M ^a,b   Challen, Grant A ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA METHYLTRANSFERASE 3A; GENOMIC DNA; LIPOCORTIN 5; DNA (CYTOSINE 5) METHYLTRANSFERASE; STEM CELL FACTOR RECEPTOR;

ACUTE LEUKEMIA; ACUTE LYMPHOBLASTIC LEUKEMIA; ANEMIA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE MARROW CELL; BONE MARROW DEPRESSION; CELL DIFFERENTIATION; CELL INFILTRATION; CELL PROLIFERATION; CFU COUNTING; CONTROLLED STUDY; ERYTHROBLAST; EXOME; FLOW CYTOMETRY; FLUORESCENCE ACTIVATED CELL SORTING; GENE EXPRESSION; GENE FREQUENCY; GENE MUTATION; GENOTYPE; HEMATOPOIETIC STEM CELL; HIGH THROUGHPUT SEQUENCING; IN VIVO STUDY; LEUKEMIA; LEUKOCYTOSIS; MOUSE; MYELODYSPLASTIC SYNDROME; MYELOID LEUKEMIA; MYELOID PROGENITOR CELL; MYELOPROLIFERATIVE DISORDER; NEUTROPENIA; NONHUMAN; ONCOGENE C KIT; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; SPLENOMEGALY; SURVIVAL; UPREGULATION; WESTERN BLOTTING; ACUTE MYELOBLASTIC LEUKEMIA; ANIMAL; BLAST CELL CRISIS; BONE MARROW; CELL LINE; CELL TRANSFORMATION; ENZYMOLOGY; GENETICS; HEMATOPOIESIS; KNOCKOUT MOUSE; METABOLISM; MORTALITY; MUTATION; PATHOLOGY;

ANIMALS; BLAST CRISIS; BONE MARROW; CELL DIFFERENTIATION; CELL LINE; CELL TRANSFORMATION, NEOPLASTIC; DNA (CYTOSINE-5-)-METHYLTRANSFERASE; HEMATOPOIESIS; HEMATOPOIETIC STEM CELLS; LEUKEMIA, MYELOID, ACUTE; MICE; MICE, KNOCKOUT; MUTATION; PROTO-ONCOGENE PROTEINS C-KIT;

EID: 84921517163     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2014-08-594564     Document Type: Article

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