Mutations in epigenetic modifiers in the pathogenesis and therapy of acute myeloid leukemia

Blood

Volumn 121, Issue 18, 2013, Pages 3563-3572

  Abdel Wahab, Omar ^a   Levine, Ross L ^a  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 (6 AMINO 9H PURIN 9 YL) 5 [[[3 [2 (5 TERT BUTYL 1H BENZIMIDAZOL 2 YL)ETHYL]CYCLOBUTYL](ISOPROPYL)AMINO]METHYL]TETRAHYDROFURAN 3,4 DIOL; ANTILEUKEMIC AGENT; CYTARABINE; DAUNORUBICIN; DNA METHYLTRANSFERASE 3A; DNA METHYLTRANSFERASE INHIBITOR; HISTONE; ISOCITRATE DEHYDROGENASE 1; ISOCITRATE DEHYDROGENASE 2; OTX 015; TRANSCRIPTION FACTOR EZH2; TRANYLCYPROMINE; UNCLASSIFIED DRUG; DNA (CYTOSINE 5) METHYLTRANSFERASE; DNA BINDING PROTEIN; ONCOPROTEIN; TET2 PROTEIN, HUMAN;

ACUTE GRANULOCYTIC LEUKEMIA; ADDITION OF SEX COMBS LIKE 1 GENE; BRD2 GENE; BRD3 GENE; BRD4 GENE; CANCER CHEMOTHERAPY; CANCER PROGNOSIS; CANCER RISK; CARCINOGENESIS; CLINICAL PRACTICE; DNA METHYLATION; DOT1L GENE; EPIGENETICS; GAIN OF FUNCTION MUTATION; GENE; GENE INACTIVATION; GENE MUTATION; GENETIC ASSOCIATION; GENETIC TRANSCRIPTION; HEMATOPOIESIS; HISTONE MODIFICATION; HUMAN; ISOCITRATE DEHYDROGENASE 1 GENE; ISOCITRATE DEHYDROGENASE 2 GENE; JMJD3 GENE; LOSS OF FUNCTION MUTATION; LSD1 GENE; MUTATIONAL ANALYSIS; NONHUMAN; PHASE 1 CLINICAL TRIAL (TOPIC); PHASE 3 CLINICAL TRIAL (TOPIC); PRIORITY JOURNAL; PROTEIN PROCESSING; RANDOMIZED CONTROLLED TRIAL (TOPIC); REVIEW; RNA INTERFERENCE; SOMATIC MUTATION; TET2 GENE; TRANSCRIPTION FACTOR EZH2 GENE; TRANSCRIPTION REGULATION; UTX GENE; ANIMAL; BIOLOGICAL MODEL; GENETIC EPIGENESIS; GENETIC PREDISPOSITION; GENETICS; MODIFIER GENE; MUTATION;

ANIMALS; DNA (CYTOSINE-5-)-METHYLTRANSFERASE; DNA-BINDING PROTEINS; EPIGENESIS, GENETIC; GENES, MODIFIER; GENETIC PREDISPOSITION TO DISEASE; HUMANS; LEUKEMIA, MYELOID, ACUTE; MODELS, GENETIC; MUTATION; PROTO-ONCOGENE PROTEINS;

MLCS; MLOWN;

EID: 84879698783     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2013-01-451781     Document Type: Review

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