Retraction: Hypoxia-inducible factors mediate coordinated RhoA-ROCK1 expression and signaling in breast cancer cells (Proceedings of the National Academy of Sciences of the United States of America (2013) 111 (E384-E393) DOI: 10.1073/pnas.1321510111);Hypoxia-inducible factors mediate coordinated RhoA-ROCK1 expression and signaling in breast cancer cells

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 3, 2014, Pages

  Gilkes, Daniele M ^a,b,c   Xiang, Lisha ^a,b   Lee, Sun Joo ^a,b   Chaturvedi, Pallavi ^a,b   Hubbi, Maimon E ^a,b   Wirtz, Denis ^c,d   Semenza, Gregg L ^a,b,c  

^a Institute for Cell Engineering   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c JOHNS HOPKINS UNIVERSITY   (United States)

^d Johns Hopkins University   (United States)

Author keywords

Cytoskeletal reprogramming; Metastasis; Migration; Oxygen; Tumor microenvironment

Indexed keywords

FOCAL ADHESION KINASE; HYPOXIA INDUCIBLE FACTOR 1ALPHA; HYPOXIA INDUCIBLE FACTOR 2ALPHA; MESSENGER RNA; MYOSIN LIGHT CHAIN; RHO KINASE; RHO KINASE 1 PROTEIN; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; UNCLASSIFIED DRUG; COLLAGEN TYPE 1; HYPOXIA INDUCIBLE FACTOR 1BETA; ROCK1 PROTEIN; ROCK2 PROTEIN; SHORT HAIRPIN RNA;

ACTIN MYOSIN INTERACTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BREAST CANCER; CANCER CELL; CANCER GROWTH; CELL INVASION; CELL MOTILITY; CONTROLLED STUDY; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; LOSS OF FUNCTION MUTATION; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; TUMOR INVASION; ACTIN POLYMERIZATION; BINDING SITE; BREAST CANCER CELL LINE; CANCER MORTALITY; CANCER SURVIVAL; CELL MIGRATION; CELL STRUCTURE; CELL VELOCITY; CELLULAR PARAMETERS; CHROMATIN IMMUNOPRECIPITATION; CONSENSUS SEQUENCE; EXPRESSION VECTOR; FOCAL ADHESION; GENE SILENCING; IMMUNOFLUORESCENCE TEST; MAMMARY GLAND FAT; METASTASIS POTENTIAL; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; SOMATIC MUTATION; STRESS FIBER; TIME LAPSE IMAGING; TRANSCRIPTION INITIATION SITE;

CYTOSKELETAL REPROGRAMMING; METASTASIS; MIGRATION; OXYGEN; TUMOR MICROENVIRONMENT;

ANIMALS; BREAST NEOPLASMS; CELL HYPOXIA; CELL LINE, TUMOR; CELL MOVEMENT; CELL SURVIVAL; COLLAGEN; CYTOSKELETON; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HEK293 CELLS; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; MICROSCOPY, CONFOCAL; MUTATION; NEOPLASM METASTASIS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; OXYGEN; PHOSPHORYLATION; RATS; RHO-ASSOCIATED KINASES; RHOA GTP-BINDING PROTEIN; SIGNAL TRANSDUCTION; TUMOR MICROENVIRONMENT;

EID: 84892930021     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.2213288119     Document Type: Erratum

References (59)

1. Jaffe AB, Hall A (2005) Rho GTPases: Biochemistry and biology. Annu Rev Cell Dev Biol 21:247-269.
2. Narumiya S, Tanji M, Ishizaki T (2009) Rho signaling, ROCK and mDia1, in transformation, metastasis and invasion. Cancer Metastasis Rev 28(1-2):65-76.
3. Olson MF, Sahai E (2009) The actin cytoskeleton in cancer cell motility. Clin Exp Metastasis 26(4):273-287.
4. Jacobs M, et al. (2006) The structure of dimeric ROCK I reveals the mechanism for ligand selectivity. J Biol Chem 281(1):260-268.
5. Amano M, et al. (1996) Phosphorylation and activation of myosin by Rho-associated kinase (Rho-kinase). J Biol Chem 271(34):20246-20249.
6. Kimura K, et al. (1996) Regulation of myosin phosphatase by Rho and Rho-associated kinase (Rho-kinase). Science 273(5272):245-248.
7. Maekawa M, et al. (1999) Signaling from Rho to the actin cytoskeleton through protein kinases ROCK and LIM-kinase. Science 285(5429):895-898.
8. Plotnikov SV, Waterman CM (2013) Guiding cell migration by tugging. Curr Opin Cell Biol 25(5):619-626.
9. Fraley SI, et al. (2010) A distinctive role for focal adhesion proteins in three-dimensional cell motility. Nat Cell Biol 12(6):598-604.
10. Mitra SK, Hanson DA, Schlaepfer DD (2005) Focal adhesion kinase: In command and control of cell motility. Nat Rev Mol Cell Biol 6(1):56-68.
11. Provenzano PP, Inman DR, Eliceiri KW, Keely PJ (2009) Matrix density-induced mechanoregulation of breast cell phenotype, signaling and gene expression through a FAK-ERK linkage. Oncogene 28(49):4326-4343.
12. Luo M, et al. (2009) Mammary epithelial-specific ablation of the focal adhesion kinase suppresses mammary tumorigenesis by affecting mammary cancer stem/progenitor cells. Cancer Res 69(2):466-474.
13. Mitra SK, Lim ST, Chi A, Schlaepfer DD (2006) Intrinsic focal adhesion kinase activity controls orthotopic breast carcinoma metastasis via the regulation of urokinase plasminogen activator expression in a syngeneic tumor model. Oncogene 25(32):4429-4440.
14. Wang W, et al. (2004) Identification and testing of a gene expression signature of invasive carcinoma cells within primary mammary tumors. Cancer Res 64(23):8585-8594.
15. Bellizzi A, et al. (2008) RhoA protein expression in primary breast cancers and matched lymphocytes is associated with progression of the disease. Int J Mol Med 22(1):25-31.
16. Chan CH, et al. (2010) Deciphering the transcriptional complex critical for RhoA gene expression and cancer metastasis. Nat Cell Biol 12(5):457-467.
17. Lane J, Martin TA, Watkins G, Mansel RE, Jiang WG (2008) The expression and prognostic value of ROCK I and ROCK II and their role in human breast cancer. Int J Oncol 33(3):585-593.
18. Liu S, Goldstein RH, Scepansky EM, Rosenblatt M (2009) Inhibition of rho-associated kinase signaling prevents breast cancer metastasis to human bone. Cancer Res 69(22):8742-8751.
19. Ma L, et al. (2010) Over expression of RhoA is associated with progression in invasive breast duct carcinoma. Breast J 16(1):105-107.
20. Brahimi-Horn MC, Chiche J, Pouysségur J (2007) Hypoxia and cancer. J Mol Med (Berl) 85(12):1301-1307.
21. Gillies RJ, Gatenby RA (2007) Hypoxia and adaptive landscapes in the evolution of carcinogenesis. Cancer Metastasis Rev 26(2):311-317.
22. Sullivan R, Graham CH (2007) Hypoxia-driven selection of the metastatic phenotype. Cancer Metastasis Rev 26(2):319-331.
23. Vaupel P, Höckel M, Mayer A (2007) Detection and characterization of tumor hypoxia using pO2 histography. Antioxid Redox Signal 9(8):1221-1235.
24. Semenza GL (2010) Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics. Oncogene 29(5):625-634.
25. Gilkes DM, et al. (2013) Collagen prolyl hydroxylases are essential for breast cancer metastasis. Cancer Res 73(11):3285-3296.
26. Gilkes DM, et al. (2013) Procollagen lysyl hydroxylase 2 is essential for hypoxia-induced breast cancer metastasis. Mol Cancer Res 11(5):456-466.
27. Chaturvedi P, et al. Kshitiz (2013) Hypoxia-inducible factor-dependent breast cancermesenchymal stem cell bidirectional signaling promotes metastasis. J Clin Invest 123(1):189-205.
28. Wong CC, et al. (2011) Hypoxia-inducible factor 1 is a master regulator of breast cancer metastatic niche formation. Proc Natl Acad Sci USA 108(39):16369-16374.
29. Zhang H, et al. (2012) HIF-1-dependent expression of angiopoietin-like 4 and L1CAM mediates vascular metastasis of hypoxic breast cancer cells to the lungs. Oncogene 31(14):1757-1770.
30. Bos R, et al. (2003) Levels of hypoxia-inducible factor-1α independently predict prognosis in patients with lymph node negative breast carcinoma. Cancer 97(6):1573-1581.
31. Dales JP, et al. (2005) Overexpression of hypoxia-inducible factor HIF-1α predicts early relapse in breast cancer: Retrospective study in a series of 745 patients. Int J Cancer 116(5):734-739.
32. Generali D, et al. (2006) Hypoxia-inducible factor-1α expression predicts a poor response to primary chemoendocrine therapy and disease-free survival in primary human breast cancer. Clin Cancer Res 12(15):4562-4568.
33. Schindl M, et al. Austrian Breast and Colorectal Cancer Study Group (2002) Overexpression of hypoxia-inducible factor 1α is associated with an unfavorable prognosis in lymph node-positive breast cancer. Clin Cancer Res 8(6):1831-1837.
34. Helczynska K, et al. (2008) Hypoxia-inducible factor-2α correlates to distant recurrence and poor outcome in invasive breast cancer. Cancer Res 68(22):9212-9220.
35. Wells A, Grahovac J, Wheeler S, Ma B, Lauffenburger D (2013) Targeting tumor cell motility as a strategy against invasion and metastasis. Trends Pharmacol Sci 34(5):283-289.
36. Ginis I, Faller DV (2000) Hypoxia affects tumor cell invasiveness in vitro: The role of hypoxia-activated ligand HAL1/13(Ku86 autoantigen). Cancer Lett 154 (2):163-174.
37. Schito L, et al. (2012) Hypoxia-inducible factor 1-dependent expression of plateletderived growth factor B promotes lymphatic metastasis of hypoxic breast cancer cells. Proc Natl Acad Sci USA 109(40):E2707-E2716.
38. Ridley AJ, et al. (2003) Cell migration: Integrating signals from front to back. Science 302(5651):1704-1709.
39. Itoh K, et al. (1999) An essential part for Rho-associated kinase in the transcellular invasion of tumor cells. Nat Med 5(2):221-225.
40. Pawitan Y, et al. (2005) Gene expression profiling spares early breast cancer patients from adjuvant therapy: Derived and validated in two population-based cohorts. Breast Cancer Res 7(6):R953-R964.
41. Minn AJ, et al. (2005) Genes that mediate breast cancer metastasis to lung. Nature 436(7050):518-524.
42. Cancer Genome Atlas Network (2012) Comprehensive molecular portraits of human breast tumours. Nature 490(7418):61-70.
43. Semenza GL, et al. (1996) Hypoxia response elements in the aldolase A, enolase 1, and lactate dehydrogenase A gene promoters contain essential binding sites for hypoxiainducible factor 1. J Biol Chem 271(51):32529-32537.
44. Kim DH, Wirtz D (2013) Predicting how cells spread and migrate: Focal adhesion size does matter. Cell Adhes Migr 7(3):293-296.
45. Vaupel P, Mayer A, Höckel M (2004) Tumor hypoxia and malignant progression. Methods Enzymol 381:335-354.
46. Martin LJ, Boyd NF (2008) Mammographic density. Potential mechanisms of breast cancer risk associated with mammographic density: Hypotheses based on epidemiological evidence. Breast Cancer Res 10(1):201.
47. Provenzano PP, et al. (2008) Collagen density promotes mammary tumor initiation and progression. BMC Med 6:11.
48. Levental KR, et al. (2009) Matrix crosslinking forces tumor progression by enhancing integrin signaling. Cell 139(5):891-906.
49. Paszek MJ, et al. (2005) Tensional homeostasis and the malignant phenotype. Cancer Cell 8(3):241-254.
50. Wong CC, et al. (2012) Inhibitors of hypoxia-inducible factor 1 block breast cancer metastatic niche formation and lung metastasis. J Mol Med (Berl) 90(7):803-815.
51. Madan R, Smolkin MB, Cocker R, Fayyad R, Oktay MH (2006) Focal adhesion proteins as markers of malignant transformation and prognostic indicators in breast carcinoma. Hum Pathol 37(1):9-15.
52. Hanna SC, et al. (2013) HIF1α and HIF2α independently activate SRC to promote melanoma metastases. J Clin Invest 123(5):2078-2093.
53. Perou CM, et al. (2000) Molecular portraits of human breast tumours. Nature 406(6797):747-752.
54. Infante JR, et al. (2012) Safety, pharmacokinetic, and pharmacodynamic phase I doseescalation trial of PF-00562271, an inhibitor of focal adhesion kinase, in advanced solid tumors. J Clin Oncol 30(13):1527-1533.
55. Kummar S, et al. (2011) Multihistology, target-driven pilot trial of oral topotecan as an inhibitor of hypoxia-inducible factor-1α in advanced solid tumors. Clin Cancer Res 17(15):5123-5131.
56. Chambers AF (2009) MDA-MB-435 and M14 cell lines: Identical but not M14 melanoma? Cancer Res 69(13):5292-5293.
57. Debnath J, Muthuswamy SK, Brugge JS (2003) Morphogenesis and oncogenesis of MCF-10A mammary epithelial acini grown in three-dimensional basement membrane cultures. Methods 30(3):256-268.
58. Krishnamachary B, Semenza GL (2007) Analysis of hypoxia-inducible factor 1α expression and its effects on invasion and metastasis. Methods Enzymol 435:347-354.
59. Ren XD, Kiosses WB, Schwartz MA (1999) Regulation of the small GTP-binding protein Rho by cell adhesion and the cytoskeleton. EMBO J 18(3):578-585.