Hypoxia affects tumor cell invasiveness in vitro: The role of hypoxia-activated ligand HAL1/13 (Ku86 autoantigen)

Cancer Letters

Volumn 154, Issue 2, 2000, Pages 163-174

  Ginis, Irene ^b   Faller, Douglas V ^a  

^a Cancer Research Center   (United States)

^b NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE   (United States)

Author keywords

Adhesion molecules; Hypoxia; Invasion; Metastasis; Tumor cells

Indexed keywords

CELL ADHESION MOLECULE; HYPOXIA ACTIVATED LIGAND; KU ANTIGEN; UNCLASSIFIED DRUG;

ANTIGEN EXPRESSION; ARTICLE; BREAST CARCINOMA; CANCER INVASION; CELL MIGRATION; FLOW CYTOMETRY; HUMAN; HUMAN CELL; HYPOXIA; METASTASIS; NEUROBLASTOMA CELL; PRIORITY JOURNAL;

ANTIGENS, NUCLEAR; BREAST NEOPLASMS; CELL ADHESION; CELL HYPOXIA; CELL MOVEMENT; COLLAGEN; DNA HELICASES; DNA-BINDING PROTEINS; DRUG COMBINATIONS; ENDOTHELIUM, VASCULAR; EXTRACELLULAR MATRIX; FLOW CYTOMETRY; HUMANS; LAMININ; LEUKOCYTES; LIGANDS; MICROSCOPY, CONFOCAL; MODELS, THEORETICAL; NEOPLASM INVASIVENESS; NEUROBLASTOMA; NUCLEAR PROTEINS; OXYGEN; PROTEOGLYCANS; TIME FACTORS; TUMOR CELLS, CULTURED; UMBILICAL VEINS; UP-REGULATION;

EID: 0034733872     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3835(00)00388-8     Document Type: Article

References (41)

1. Ginis I., Mentzer S.J., Faller D.V. Hypoxia induces lymphocyte adhesion to human mesenchymal cells via an LFA-1-dependent mechanism. Am. J. Physiol. 264:(3, part 1):1992;C617-C624.
2. Ginis I., Mentzer S.J., Faller D.V. Oxygen tension regulates neutrophil adhesion to human endothelial cells via an LFA-1-dependent mechanism. J. Cell Physiol. 157:1993;569-578.
3. Ginis I., Mentzer S.J., Faller D.V. Characterization of a hypoxia-responsive adhesion molecule for leukocytes on human endothelial cells. J. Immunol. 155:1995;802-810.
4. Faller D.V. Hypoxia, Nitric oxide and vasoactive gene transcription. Parkinson J. Nitric Oxide, Cytochrome P450 and Sexual Steroid Hormones. 1997;75-116 Springer-Verlag, New York.
5. Reeves W.H. Antibodies to the p70/p80 (Ku) antigens in systemic lupus erythematosus. Rheum. Dis. Clin. North Am. 18:(2):1992;391-414.
6. Han Z., Johnston C., Reeves W.H., Carter T., Wyche J.H., Hendrickson E. Characterization of a Ku86 variant protein that results in altered DNA binding and diminished DNA-dependent protein kinase activity. J. Biol. Chem. 271:1996;14098-14104.
7. Dalziel R.G., Mendelson S.C., Quinn J.P. The nuclear autoimmune antigen Ku is also present on the cell surface. Autoimmunity. 13:(4):1992;265-267.
8. Prabhakar B.S., Allaway G.P., Srinivasappa J., Notkins A.L. Cell surface expression of the 70-kDa component of Ku, a DNA-binding nuclear autoantigen. J. Clin. Invest. 86:(4):1990;1301-1305.
9. Teoh G., Urashima M., Greenfield E.A., Nguyen K.A., Lee J.F., Chauhan D., Ogata A., Treon S.P., Anderson K.C. The 86-kDa subunit of Ku autoantigen mediates homotypic and heterotypic adhesion of multiple myeloma cells. J. Clin. Invest. 101:(6):1998;1379-1388.
10. Fewell J.W., Kuff E.L. Intracellular redistribution of Ku immunoreactivity in response to cell-cell contact and growth modulating components in the medium. J. Cell Sci. 109:(7):1996;1937-1946.
11. La Reviere G., Schipper C.A., Collard J.G., Roos E.C. Invasiveness in hepatocyte and fibroblast monolayers and metastatic potential of T-cell hybridomas in mice. Cancer Res. 48:1988;3405-3410.
12. Echtermeyer F., Schober S., Poschl E., von der Mark H., von der Mark K. Specific induction of cell motility on laminin by α7 integrin. J. Biol. Chem. 272:(26):1996;2071-2075.
13. Chapman J.D., Engelhardt E.L., Stobbe C.C., Schneider R.F., Hanks G.E. Measuring hypoxia and predicting tumor radioresistance with nuclear medicine assays. Radiother. Oncol. 46:(3):1998;229-237.
14. Brown J.M. Tumor hypoxia, drug resistance, and metastases. J. Natl. Cancer Inst. 82:(5):1990;338-339.
15. Dachs G.U., Chaplin D. Microenvironmental control of gene expression: implications for tumor angiogenesis, progression, and metastasis. Semin. Radiat. Oncol. 8:(3):1998;208-216.
16. Young S.D., Hill R.P. Effects of reoxygenation on cells from hypoxic regions of solid tumors: anti-cancer drug sensitivity and metastatic potential. J. Natl. Cancer Inst. 82:1990;371-380.
17. Young S.D., Marshall R.S., Hill R.P. Hypoxia induces DNA overreplication and enhances metastatic potential of murine tumor cells. Proc. Natl. Acad. Sci. USA. 85:1988;9533-9537.
18. Schlappack O.K., Zimmermann A., Hill R.P. Glucose starvation and acidosis: effect on experimental metastatic potential, DNA content and MTX resistance of murine tumor cells. Br. J. Cancer. 64:1991;663-670.
19. Stackpole C.W., Groszek L., Kalbag S.S. Benign to malignant B16 melanoma progression induced in two stages in vitro by exposure to hypoxia. J. Natl. Cancer Inst. 86:1994;361-367.
20. Anderson G.R., Stoler D.L., Scarcello L.A. Retrotransposon-like VL30 elements are efficiently induced in anoxic rat fibroblasts. J. Mol. Biol. 205:1989;765-769.
21. Ausserer W.A., Bourrat-Floeck B., Green C.J., Laderoutr K.R., Sutherland R.M. Regulation of c-jun expression during hypoxic and low-glucose stress. Mol. Cell Biol. 14:1994;5032-5042.
22. Bandyopadhyay R.S., Phelan M., Faller D.V. Hypoxia induces AP-1-regulated genes and AP-1 transcription factor binding in human endothelial and other cell types. Biochim. Biophys. Acta; 1264:(1):1995;72-78.
23. Bandyopadhyay R.S., Faller D.V. Regulation of c-jun gene expression by hypoxia in endothelial cells. Endothelium. 5:1997;95-106.
24. Muller J.M., Krauss B., Kaltschmidt C., Baeuerle P.A., Rupec R.A. Hypoxia induces c-fos transcription via mitogen-activated protein kinase-dependent pathway. J. Biol. Chem. 272:(37):1997;23435-23439.
25. Faller D.V. Endothelial cell responses to hypoxic stress. Clin. Exp. Pharmacol. Physiol. 26:1999;74-84.
26. Heacock C.S., Sutherland R.M. Enhanced synthesis of stress proteins caused by hypoxia and relation to altered cell growth and metabolism. Br. J. Cancer. 62:1990;217-225.
27. Thompson E.W., Paik S., Brunner N., Sommers C.L., Zugmaier G., Clarke R., Shima T.B., Torri J., Donahue S., Lippman M.E., et al. Association of increased basement membrane invasiveness with absence of estrogen receptor and expression of vimentin in human breast cancer cell lines. J. Cell Physiol. 150:1992;534-544.
28. Krtolica A., Ludlow J.W. Hypoxia arrests ovarian carcinoma cell cycle progression, but invasion is unaffected. Cancer Res. 56:1996;1168-1173.
29. Jang A., Hill R.P. An examination of the effects of hypoxia, acidosis, and glucose starvation on the expression of metastasis-associated genes in murine tumor cells. Clin. Exp. Metastasis. 15:(5):1997;469-483.
30. Himelstein B.P., Koch C.J. Studies of type IV collagenase regulation by hypoxia. Cancer Lett. 124:(2):1998;127-133.
31. Cuvier C., Jang A., Hill R.P. Exposure to hypoxia, glucose starvation and acidosis: effect on invasive capacity of murine tumor cells and correlation with cathepsin (L+B) secretion. Clin. Exp. Metastasis. 15:(1):1997;19-25.
32. Rabinovitz I., Mercurio A.M. The integrin alpha6beta4 functions in carcinoma cell migration on laminin-1 by mediating the formation and stabilization of actin-containing motility structures. J. Cell Biol. 139:(7):1997;1873-1884.
33. Nossal R., Weiss G.H. A descriptive theory of cell migration on surfaces. J. Theor. Biol. 47:1974;103-113.
34. Hasan N.M., Adams G.E., Joiner M.C., Marshall J.F., Hart I.R. Hypoxia facilitates tumor cell detachment by reducing expression of surface adhesion molecules and adhesion to extracellular matrices without loss of cell viability. Br. J. Cancer. 77:(11):1998;1799-1805.
35. Qaian F., Vaux D.L., Weissman I.L. Expression of the integrin a4b1 on melanoma cells can inhibit the invasive stage of metastasis formation. Cell. 77:1994;335-347.
36. Le Romancer M., Reyl-Desmars F., Cherifi Y., Pigeon C., Bottari S., Meyer O., Lewin M.J. The 86-kDa subunit of autoantigen Ku is a somatostatin receptor regulating protein phosphatase-2A activity. J. Biol. Chem. 269:(26):1994;17464-17468.
37. Tovari J., Szende B., Bocsi J., Falaschi A., Simoncsits A., Pongor S., Erchegyi J., Stetak A., Keri G. A somatostatin analogue induces translocation of Ku 86 autoantigen from the cytosol to the nucleus in colon tumour cells. Cell Signal. 10:1998;277-282.
38. Leszczynski D., Dunsky K., Josephs M.D., Zhao Y., Foegh M.L. Angiopeptin, a somatostatin-14 analogue, decreases adhesiveness of rat leukocytes to unstimulated and IL-1β-activated rat heart endothelial cells. Life Sci. 57:(15):1995;PL217-PL223.
39. Gastpar H., Zoltobrocki M., Weissgerber P.W. The inhibition of cancer cell stickiness by somatostatin. Res. Exp. Med. (Berl.). 182:(1):1983;1-6.
40. Patel Y.C. Somatostatin and its receptor family. Front. Neuroendocrinol. 20:(3):1999;157-198.
41. Rofstad E.K., Danielsen T. Hypoxia-induced metastasis of human melanoma cells: involvement of vascular endothelial growth factor-mediated angiogenesis. Br. J. Cancer. 80:(11):1999;1697-1707.