Hypoxia-inducible factors and RAB22A mediate formation of microvesicles that stimulate breast cancer invasion and metastasis

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 31, 2014, Pages

  Wang, Ting ^a,b   Gilkes, Daniele M ^b,c   Takano, Naoharu ^b,c   Xiang, Lisha ^b,c   Luo, Weibo ^b,d   Bishop, Corey J ^e   Chaturvedi, Pallavi ^b,c   Green, Jordan J ^e   Semenza, Gregg L ^b,c,d  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b Institute for Cell Engineering   (United States)

^c JOHNS HOPKINS UNIVERSITY   (United States)

^d JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e Johns Hopkins University   (United States)

Author keywords

Mammary fat pad implantation; Orthotopic transplantation; Oxygen; Triple negative breast cancer; Tumor microenvironment

Indexed keywords

FOCAL ADHESION KINASE; HYPOXIA INDUCIBLE FACTOR; MESSENGER RNA; PROTEIN RAB22A; RAB PROTEIN; UNCLASSIFIED DRUG;

ANGIOGENESIS; ARTICLE; BREAST CANCER; BREAST CANCER CELL LINE; BREAST METASTASIS; CANCER MORTALITY; CELL BUDDING; CELL MIGRATION; CELL STIMULATION; CELL SURFACE; COMPARATIVE STUDY; DISTANT METASTASIS FREE SURVIVAL; ENZYME ACTIVITY; FLUORESCENCE MICROSCOPY; FOCAL ADHESION; GENE EXPRESSION; HUMAN; HUMAN CELL; HYPOXIA; MEMBRANE FUSION; METASTASIS FREE SURVIVAL; PRIMARY TUMOR; PRIORITY JOURNAL; PROTEIN DEFICIENCY; PROTEIN FUNCTION; REAL TIME POLYMERASE CHAIN REACTION; TUMOR INVASION;

MAMMARY FAT PAD IMPLANTATION; ORTHOTOPIC TRANSPLANTATION; OXYGEN; TRIPLE NEGATIVE BREAST CANCER; TUMOR MICROENVIRONMENT;

ANIMALS; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; BREAST NEOPLASMS; CELL HYPOXIA; CELL LINE, TUMOR; EXOSOMES; EXTRACELLULAR MATRIX; FEMALE; FOCAL ADHESIONS; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE KNOCKDOWN TECHNIQUES; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; LUNG NEOPLASMS; MICE; MICE, SCID; NEOPLASM INVASIVENESS; NEOPLASM METASTASIS; PROTEIN TRANSPORT; RAB GTP-BINDING PROTEINS; RNA, MESSENGER; SURVIVAL ANALYSIS;

EID: 84905643012     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1410041111     Document Type: Article

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