The longitudinal associations between C-reactive protein and depressive symptoms: Evidence from the English Longitudinal Study of Ageing (ELSA)

International Journal of Geriatric Psychiatry

Volumn 30, Issue 9, 2015, Pages 976-984

  Au, Bonnie ^a,b   Smith, Kimberley J ^a,b   Gariépy, Geneviève ^a,b   Schmitz, Norbert ^a,b,c  

^a MCGILL UNIVERSITY   (Canada)

^b DOUGLAS MENTAL HEALTH UNIVERSITY INSTITUTE   (Canada)

^c Montreal Diabetes Research Center   (Canada)

Author keywords

C reactive protein; depression; inflammation; longitudinal; older adults

Indexed keywords

C REACTIVE PROTEIN; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; BIOLOGICAL MARKER;

ADULT; AGED; ARTICLE; BODY MASS; CLINICAL EVALUATION; DEMOGRAPHY; DEPRESSION; DISEASE ASSOCIATION; EDUCATIONAL STATUS; EMPLOYMENT STATUS; FEMALE; FOLLOW UP; HUMAN; LONGITUDINAL STUDY; MAJOR CLINICAL STUDY; MALE; MARRIAGE; PHYSICAL ACTIVITY; PROTEIN BLOOD LEVEL; SMOKING; SOCIAL STATUS; SYMPTOMATOLOGY; AGING; ENGLAND; METABOLISM; MIDDLE AGED; PHYSIOLOGY; PROSPECTIVE STUDY; PSYCHOLOGICAL RATING SCALE; RISK FACTOR; STATISTICAL MODEL; VERY ELDERLY;

AGED; AGED, 80 AND OVER; AGING; BIOMARKERS; C-REACTIVE PROTEIN; DEPRESSIVE DISORDER; ENGLAND; FEMALE; HUMANS; LOGISTIC MODELS; LONGITUDINAL STUDIES; MALE; MIDDLE AGED; PROSPECTIVE STUDIES; PSYCHIATRIC STATUS RATING SCALES; RISK FACTORS;

EID: 84938059502     PISSN: 08856230     EISSN: 10991166     Source Type: Journal    
DOI: 10.1002/gps.4250     Document Type: Article

References (49)

1. Aging. 2007. Why Population Aging Matters: A Global Perspective. National Institute on Aging.
2. Alexopoulos GS,. 2005. Depression in the elderly. Lancet 365: 1961-70.
3. Almeida OP, Norman PE, Allcock R, et al,. 2009. Polymorphisms of the CRP gene inhibit inflammatory response and increase susceptibility to depression: the Health in Men Study. Int J Epidemiol 38: 1049-59.
4. Almeida OP, Norman P, Hankey GJ, Jamrozik K, Flicker L,. 2007. The association between C-reactive protein concentration and depression in later life due to poor physical health: Results from the Health in Men Study (HIMS). Psychol Med 37: 1775-1786.
5. Barberato SH, Bucharles SG, De Souza AM, et al,. 2013. Association between inflammatory markers and left atrial enlargement in patients on hemodialysis. Arq Bras Cardiol 100: 141-6.
6. Baune BT, Smith E, Reppermund S, et al,. 2012. Inflammatory biomarkers predict depressive, but not anxiety symptoms during aging: the prospective Sydney Memory and Aging Study. Psychoneuroendocrinology 37: 1521-30.
7. Becker E, Boreham R, Chaudhury M, et al,. 2006. Quality control of blood saliva and urine analytes. In Health survey for England 2004, methodology and documentation, Vol 2, Sproston K, Mindell J, (eds.). The Information Centre: London; 34-41
8. Capuron L, Miller AH,. 2011. Immune system to brain signaling: Neuropsychopharmacological implications. Pharmacol Ther 130: 226-238.
9. Castanon N, Lasselin J, Capuron L,. 2014. Neuropsychiatric comorbidity in obesity: role of inflammatory processes. Front Endocrinol 5: 1-9.
10. Cetin DC, Nasr G,. 2014. Obesity in the elderly: More complicated than you think. Cleve Clin J Med 81: 51-61.
11. Chapman DP, Perry GS,. 2008. Depression as a major component of public health for older adults. Prev Chronic Dis 5: A22.
12. Choi J, Joseph L, Pilote L,. 2013. Obesity and C-reactive protein in various populations: a systematic review and meta-analysis. Obes Rev 14: 232-44.
13. Cummings P,. 2009. The relative merits of risk ratios and odds ratios. Arch Pediatr Adolesc Med 163: 438-45.
14. Currie D,. 2013. Major causes of disability, death shift around the globe: Chronic diseases now taking the lead. Nation's Health 43: 1-22.
15. Daly M,. 2013. The relationship of C-reactive protein to obesity-related depressive symptoms: A longitudinal study. Obesity 21: 248-250.
16. Dantzer R, O'Connor JC, Freund GG, Johnson RW, Kelley KW,. 2008. From inflammation to sickness and depression: when the immune system subjugates the brain. Nat Rev Neurosci 9: 46-56.
17. Das UN,. 2011. Molecular Basis of Health and Disease. USA, Springer: New York.
18. de Wit L, Luppino F, Van Straten A, et al,. 2010. Depression and obesity: a meta-analysis of community-based studies. Psychiatry Res 178: 230-5.
19. Dunbar. 1992. Allied Dunbar National Fitness Survey: main findings. Activity and Health Research. Sports Council and Health Education Authority: London.
20. Eder K, Baffy N, Falus A, Fulop AK,. 2009. The major inflammatory mediator interleukin-6 and obesity. Inflamm Res 58: 727-36.
21. Elovainio M, Keltikangas-Jarvinen L, Pulkki-Raback L, et al,. 2006. Depressive symptoms and C-reactive protein: the Cardiovascular Risk in Young Finns Study. Psychol Med 36: 797-805.
22. Fiske A, Wetherell JL, Gatz M,. 2009. Depression in older adults. Annu Rev Clin Psychol 5: 363-89.
23. Forti P, Rietti E, Pisacane N, et al,. 2010. Blood inflammatory proteins and risk of incident depression in the elderly. Dement Geriatr Cogn Disord 29: 11-20.
24. Hamer M, Batty GD, Kivimaki M,. 2012. Risk of future depression in people who are obese but metabolically healthy: the English longitudinal study of ageing. Mol Psychiatry 17: 940-5.
25. Hamer M, Molloy GJ, De Oliveira C, Demakakos P,. 2009. Persistent depressive symptomatology and inflammation: to what extent do health behaviours and weight control mediate this relationship? Brain Behav Immun 23: 413-8.
26. Howren MB, Lamkin DM, Suls J,. 2009. Associations of depression with C-reactive protein, IL-1, and IL-6: a meta-analysis. Psychosom Med 71: 171-86.
27. Ito T, Ikeda U,. 2003. Inflammatory cytokines and cardiovascular disease. Curr Drug Targets Inflamm Allergy 2: 257-65.
28. Katon WJ,. 2011. Epidemiology and treatment of depression in patients with chronic medical illness. Dialogues Clin Neurosci 13: 7-23.
29. Krishnadas R, Cavanagh J,. 2012. Depression: An inflammatory illness? J Neurol Neurosurg Psychiatry 83: 495-502.
30. Lee Y, Choi K, Lee YK,. 2001. Association of comorbidity with depressive symptoms in community-dwelling older persons. Gerontology 47: 254-62.
31. Luukinen H, Jokelainen J, Hedberg P,. 2010. The relationships between high-sensitivity C-reactive protein and incident depressed mood among older adults. Scand J Clin Lab Invest 70: 75-9.
32. Missinne S, Vandeviver C, van de Velde S, Bracke P,. 2014. Measurement equivalence of the CES-D 8 depression-scale among the ageing population in eleven European countries. Soc Sci Res 46: 38-47.
33. O'Connor MF, Bower JE, Cho HJ, et al,. 2009. To assess, to control, to exclude: Effects of biobehavioral factors on circulating inflammatory markers. Brain Behav Immun 23: 887-897.
34. Pearson TA, Mensah GA, Alexander RW, et al,. 2003. Markers of inflammation and cardiovascular disease: application to clinical and public health practice: A statement for healthcare professionals from the Centers for Disease Control and Prevention and the American Heart Association. Circulation 107: 499-511.
35. Penninx BH, Guralnik JM, Ferrucci L, et al,. 1998. DEpressive symptoms and physical decline in community-dwelling older persons. JAMA 279: 1720-1726.
36. Penninx BWJH, Milaneschi Y, Lamers F, Vogelzangs N,. 2013. Understanding the somatic consequences of depression: Biological mechanisms and the role of depression symptom profile. BMC Med 11: 1-14.
37. Radloff LS,. 1977. The CES-D Scale: A Self-Report Depression Scale for Research in the General Population. Appl Psychol Meas 1: 385-401.
38. Rosmond R, Bjorntorp P,. 2000. The hypothalamic-pituitary-adrenal axis activity as a predictor of cardiovascular disease, type 2 diabetes and stroke. J Intern Med 247: 188-97.
39. Silic A, Karlovic D, Serretti A,. 2012. Increased inflammation and lower platelet 5-HT in depression with metabolic syndrome. J Affect Disord 141: 72-78.
40. Sorensen CJ, Pedersen OB, Petersen MS, et al,. 2014. Combined oral contraception and obesity are strong predictors of low-grade inflammation in healthy individuals: results from the Danish Blood Donor Study (DBDS). PLoS One 9: e88196.
41. Statistics 2013. Annual Mid-year Population Estimates for England and Wales, 2012. UK National Statistics.
42. Steffick D,. 2000. Documentation of Affective Functioning Measures in the Health and Retirement Study (HRS/AHEAD Documentation Report DR-005) Survey Research Center University of Michigan USA.
43. Stewart JC, Rand KL, Muldoon MF, Kamarck TW,. 2009. A prospective evaluation of the directionality of the depression-inflammation relationship. Brain Behav Immun 23: 936-44.
44. Tamakoshi K, Yatsuya H, Kondo T, et al,. 2003. The metabolic syndrome is associated with elevated circulating C-reactive protein in healthy reference range, a systemic low-grade inflammatory state. Int J Obes Relat Metab Disord 27: 443-449.
45. Ustun TB, Ayuso-Mateos JL, Chatterji S, Mathers C, Murray CJ,. 2004. Global burden of depressive disorders in the year 2000. Br J Psychiatry 184: 386-92.
46. Valkanova V, Ebmeier KP, Allan CL,. 2013. CRP, IL-6 and depression: a systematic review and meta-analysis of longitudinal studies. J Affect Disord 150: 736-44.
47. van den Biggelaar AH, Gussekloo J, De Craen AJ, et al,. 2007. Inflammation and interleukin-1 signaling network contribute to depressive symptoms but not cognitive decline in old age. Exp Gerontol 42: 693-701.
48. Zivin K, Llewellyn DJ, Lang IA, et al,. 2010. Depression among older adults in the United States and England. Am J Geriatr Psychiatry 18: 1036-44.
49. Zunszain PA, Anacker C, Cattaneo A, Carvalho LA, Pariante CM,. 2011. Glucocorticoids, cytokines and brain abnormalities in depression. Prog Neuropsychopharmacol Biol Psychiatry 35: 722-9.