Chronic immune stimulation correlates with reduced phenylalanine turnover

Current Drug Metabolism

Volumn 9, Issue 7, 2008, Pages 622-627

  Neurauter, G ^a   Schrocksnadel K ^b   Scholl Burgi S ^a   Sperner Unterweger, B ^a   Schubert, C ^a   Ledochowski, M ^a   Fuchs, Dietmar ^a  

^a INNSBRUCK MEDICAL UNIVERSITY   (Austria)

^b INNSBRUCK MEDICAL UNIVERSITY   (Austria)

Author keywords

Immune activation; Inflammation; Interferon ; Oxidative stress; Phenylalanine; Phenylalanine 4 hydroxylase (PAH); Tetrahydrobiopterin (BH4)

Indexed keywords

ACETYLSALICYLIC ACID; ADRENALIN; ALPHA TOCOPHEROL; ASCORBIC ACID; CATECHOLAMINE; DOPAMINE; GAMMA INTERFERON; HOMOCYSTEINE; NEOPTERIN; NORADRENALIN; PHENYLALANINE; PHENYLALANINE 4 MONOOXYGENASE; REACTIVE OXYGEN METABOLITE; RESVERATROL; SALICYLIC ACID; SEROTONIN; TETRAHYDROBIOPTERIN;

AMINO ACID METABOLISM; ANTIINFLAMMATORY ACTIVITY; BIOSYNTHESIS; CORRELATION ANALYSIS; DEPRESSION; HUMAN; HYPERHOMOCYSTEINEMIA; HYPERPHENYLALANINEMIA; IMMUNOSTIMULATION; IMMUNOSURVEILLANCE; MONOAMINE METABOLISM; MOOD DISORDER; NEUROTRANSMISSION; OXIDATIVE STRESS; PHENYLKETONURIA; REVIEW; RISK FACTOR;

ANIMALS; BIOGENIC MONOAMINES; BIOPTERIN; HOMOCYSTEINE; HUMANS; IMMUNE SYSTEM; INFLAMMATION; INTERFERON TYPE II; OXIDATIVE STRESS; PHENYLALANINE;

EID: 52449126348     PISSN: 13892002     EISSN: None     Source Type: Journal    
DOI: 10.2174/138920008785821738     Document Type: Review

References (62)

1. Dantzer, R.; O'Connor, J.C.; Freund, G.G.; Johnson, R.W. and Kelley, K.W. (2008) Nat. Rev. Neurosci., 9, 46-56.
2. Raison, C.L.; Capuron, L. and Miller, A.H. (2006) Trends Immunol., 27, 24-31.
3. Wirleitner, B.; Neurauter, G.; Schroecksnadel, K.; Frick, B. and Fuchs, D. (2003) Curr. Med. Chem., 10, 1581-91.
4. Widner, B.; Latch, A.; Sperner-Unterweger, B.; Ledochowski, M. and Fuchs, D. (2002) Brain Behav. Immun., 16, 590-5.
5. Ruhé, H.G.; Mason, N.S. and Schene, A.H. (2007) Mol. Psychiatry 12, 331-59.
6. Maes, M.; Lin, A.H.; Verkerk, R.; Delmeire, L.; Van Gastel, A.; Van der Planken, M. and Scharpé, S. (1999) Neuropsychopharmacology, 20, 188-97.
7. Harrison, B.J.; Olver, J.S.; Norman, T.R.; Nathan, P.J. Effects of serotonin and catecholamine depletion on interleukin-6 activation and mood in human volunteers. (2002) Hum. Psychopharmacol., 17, 293-7.
8. Werner-Felmayer, G.; Golderer, G. and Werner, E. R. (2002) Curr. Drug Metab., 3, 159-73.
9. Widner, B.; Ledochowski, M. and Fuchs, D. (2000) Curr. Drug Metab., 1, 193-204.
10. Devoino, L.; Alperina, E. and Idova, G. (1988) Int. J. Neurosci., 40, 271-88.
11. Devoino, L.; Morozova, N. and Cheido, M. (1988) Int. J. Neurosci., 40, 111-28.
12. Shintaku, H. (2002) Curr. Drug Metab., 3, 123-31.
13. DiLella, A. G.; Kwok, S.C.M.; Ledley, F.D.; Marvit, J. and Woo, S.L.C. (1986) Biochemistry, 25, 743-9.
14. Guldberg, P.; Henriksen, K.F.; Sipila, I.; Guider, F. and de la Chapelle, A. (1995) J. Med. Genet., 32, 976-8.
15. Muntau, A.C.; Röschinger, W.; Habich, M.; Demmelmair, H.; Hoffmann, B.; Sommerhoff, C. P. and Roscher, A. A. (2002) N. Engl. J. Med., 347, 2122-32.
16. Romagnani, S. (2001) Curr. Opin. Allergy Clin. Immunol., 1, 73-8.
17. Nathan, C.F.; Murray, H.W.; Wiebe, M.E. and Rubin, B.Y. (1983) J. Exp. Med., 158, 670-89.
18. Murr, C.; Widner, B.; Wirleitner, B. and Fuchs, D. (2002) Curr. Drug Metabol., 3, 175-87.
19. Denz, H.; Fuchs, D.; Huber, H.; Nachbaur, D.; Reibnegger, G.; Thaler, J.; Werner, E.R. and Wachter, H. (1990) Eur. J. Haematol., 44, 186-9.
20. Fuchs, D.; Möller, A. A.; Reibnegger, G.; Stöckle, E.; Werner, E.R. and Wachter, H. (1990) J. Aquir. Immune Defic. Syndr., 3, 873-6.
21. Leblhuber, F.; Walli, J.; Demel, U.; Tilz, G.P.; Widner, B. and Fuchs, D. (1999) Clin. Chem. Lab. Med., 37, 429-31.
22. Widner, B.; Leblhuber, F. and Fuchs, D. (2002) J. Neural Transm., 109, 181-9.
23. Tatzber, F.; Rabl, H.; Koriska, K.; Erhart, U.; Puhl, H.; Waeg, G.; Krebs, A. and Esterbauer, H. (1991) Atherosclerosis 89, 203-8.
24. Avanzas, P.; Arroyo-Espliguero, R.; Quiles, J.; Roy, D. and Kaski, J.C. (2005) Eur. Heart J., 26, 457-63.
25. Kaski, J.C.; Consuegra- Sanchez, L.; Fernandez-Berges, D.J.; Cruz-Fernandez, J.M.; Garcia-Moll, X.; Marrugat, J.; Mostaza, J.; Toro-Cebada, R.; González-Juanatey, J.R.; Guzmán-Martínez, G. and on behalf of the SIESTA Investigators. (2008) Atherosclerosis (in press).
26. Hoffmann, G.; Wirleitner, B. and Fuchs, D. (2003) Inflamm. Res., 52, 313-21.
27. Halliwell, B. (1991) Am. J. Med., 91, 14S-22S.
28. Hronek, M.; Zadak, Z.; Solichova, D.; Jandik, P. and Melichar, B. (2000) Nutrition 16, 189-91.
29. Murr, C.; Schroecksnadel, K.; Winklhofer-Roob, B.; Mangge, H.; Boehm, B.O.; Winkelmann, B.R.; März, W. and Fuchs, D. (2008) Atherosclerosis, [Epub ahead of print].
30. Montuschi, P.; Barnes, P. and Roberts, L.J. (2007) Curr. Med. Chem., 14, 703-17.
31. Connor, M.J.; Pheasant, A.E. and Blair, J.A. (1979) Biochem. J., 178, 795-7.
32. Fuchs, D.; Jäger, M.; Widner, B.; Wirleitner, B.; Artner-Dworzak, E. and Leblhuber, F. (2001) Clin. Chem. Lab. Med., 39, 691-4.
33. Widner, B.; Fuchs, D.; Leblhuber, F. and Sperner-Unterweger, B. (2001) J. Neurol. Neurosurg. Psychiatry 70, 419.
34. Andersson, D.N.; Wilkinson, A.M.; Abou-Saleh, M.T. and Blair, J.A. (1994) Acta Psychiatr. Scand., 90, 10-3.
35. Watanabe, A.; Higashi, T.; Sakata, T. and Nagashima, H. (1984) Cancer, 54, 1875-82.
36. Roth, E.; Zöch, G.; Schulz, F.; Karner, J.; Muehlbacher, F.; Hamilton, G.; Mauritz, W.; Sporn, P. and Funovics, J. (1985) Clin. Chem., 31, 1305-9.
37. Rath, T.; Roth, E.; Keidl, R. and Meissl, G. (1987) Scand. J. Plast. Reconstr. Surg. Hand. Surg., 21, 297-300.
38. Ollenschläger, G.; Jansen, S.; Schindler, J.; Rasokat, H.; Schrappe-Bächer, M. and Roth, E. (1988) Clin. Chem., 34, 1787-9.
39. Chang, X.J.; Yang, C.C.; Hsu, W.S.; Xu, W.Z. and Shih, T.S. (1983) Burns Incl. Therm. Inj., 9, 240-8.
40. Roth, E., 1987. Veränderungen im Ammosäuren- und Proteinstoffwechsel bei chirurgischen Patienten. In: Klinische Ernährung, vol., 26, Ahnefeld, F.W.; Hartig, W. and Holm, E. (eds.), Zuckschwerdt-Verlag, München-Bern-Wien-New York, pp38.
41. Ploder, M.; Neurauter, G.; Spittler, A.; Schroecksnadel, K.; Roth, E. and Fuchs, D. (2008) Amino Acids (in press).
42. Sperner-Unterweger, B.; Grahmann, A. V.; Neurauter, G.; Klieber, M.; Zeimet, A.; Ledochowski M. and Fuchs, D. (2008) Cancer Lett. (in press).
43. Schroecksnadel, K.; Winkler, C.; Wirleitner, B.; Schennach, H. and Fuchs, D. (2005) Clin. Exp. Immunol., 140, 41-5.
44. Winkler, C.; Schroecksnadel, K.; Schennach, H. and Fuchs, D. (2007) Int. Arch. Allergy Immunol., 142, 127-32.
45. Wirleitner, B.; Schroecksnadel, K.; Winkler, C.; Schennach, H. and Fuchs, D. (2005) Immunol. Lett., 100, 159-63.
46. Heller, R.; Unbehaun A.; Schellenberg, B.; Mayer, B.; Werner-Felmayer, G. and Werner E.R. (2001) J. Biol. Chem., 276, 40-7.
47. Stabler, S.P.; Marcell, P.D.; Podell, E.R.; Allen, R.H.; Savage, D.G. and Lindenbaum, J. (1988) J. Clin. Invest., 81, 466-74.
48. Lindenbaum, J.; Healton, E.B.; Savage, D.G.; Brust, J.C.; Garrett, T.J.; Podell, E.R.; Marcell, P.D.; Stabler, S.P. and Allen, R.H. (1988) N. Engl. J. Med., 318, 1720-8.
49. Herrmann, W.; Herrmann, M. and Obeid, R. (2007) Curr. Drug Metab., 8, 17-31.
50. Boushey, C.J.; Beresford, S.A.; Omenn, G.S. and Motulsky, A.G. (1995) J. Am. Med. Assoc., 274, 1049-57.
51. Eikelboom, J.W.; Lonn, E.; Genest, J.Jr.; Hankey, G. and Yusuf, S. (1999) Ann. Intern. Med., 131, 363-75.
52. Kuhn, W.; Roebroek, R.; Blom, H.; Van Oppenraaij, D.; Przuntek, H.; Kretschmer, A.; Büttner, T.; Woitalla D. and Müller, T. (1998) Eur. Neurol., 40, 225-7.
53. Nourhashemi, F.; Gillette-Guyonnet, S.; Andrieu, S.; Ghisolfi, A.; Ousset, P.J.; Grandjean, H.; Grand, A.; Pous, J.; Vellas, B. and Albarede, J.L. (2000) Am. J. Clin. Nutr., 71,: 643S-649S.
54. Miller, J. W. (1999) Nutr. Rev., 57, 126-9.
55. Leblhuber, F.; Walli, J.; Artner-Dworzak, E.; Vrecko, K.; Widner, B.; Reibnegger, G. and Fuchs, D. (2000) J. Neural. Transm., 107, 1469-74.
56. Auer, J.; Berent, R.; Weber, T.; Lassing, E. and Eber, B. (2001) Wien. Med. Wochenschr., 151, 25-8.
57. Gottsater, A.; Anwaar, I.; Eriksson, K.F.; Mattiasson, I. and Lindgarde, F. (2000) Angiology 51, 489-97.
58. Powers, R.W.; Evans, R.W.; Majors, A.K.; Ojimba, J. I.; Ness, R.B.; Crombleholme, W.R. and Roberts, J.M. (1998) Am. J. Obstet. Gynecol., 179, 1605-11.
59. Widner, B.; Enzinger, C.; Laich, A.; Wirleitner, B. and Fuchs, D. (2002) Curr. Drug Metab., 3, 225-32.
60. Bottigheri, T.; Laundy, M.; Crellin, R.; Toone, B.K.; Carney, M.W. and Reynolds, E.H. (2000) J. Neurol. Neurosurg. Psychiatry 69, 228-32.
61. Botez, M.I.; Young, S.N.; Bachevalier, J. and Gauthier, S. (1979) Nature 278, 182-3.
62. Botez, M.I.; Young, S.N.; Bachevalier, J. and Gauthier, S. (1982) Ann. Neurol., 12, 479-84.