메뉴 건너뛰기




Volumn 15, Issue 11, 2014, Pages 1009-1016

Plasticity of mesenchymal stem cells in immunomodulation: Pathological and therapeutic implications

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE RECEPTOR CXCR3; CYCLOSPORIN A; DEXAMETHASONE; EPIDERMAL GROWTH FACTOR; FIBROBLAST GROWTH FACTOR; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1 RECEPTOR; INTERLEUKIN 10; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; INTERLEUKIN 6; MONOCYTE CHEMOTACTIC PROTEIN 1; PLATELET DERIVED GROWTH FACTOR; PROSTAGLANDIN E2; SCATTER FACTOR; SOMATOMEDIN; STROMAL CELL DERIVED FACTOR 1; TOLL LIKE RECEPTOR 3; TOLL LIKE RECEPTOR 4; TRANSFORMING GROWTH FACTOR BETA; VASCULOTROPIN;

EID: 84908132425     PISSN: 15292908     EISSN: 15292916     Source Type: Journal    
DOI: 10.1038/ni.3002     Document Type: Review
Times cited : (1157)

References (86)
  • 1
    • 84860238652 scopus 로고    scopus 로고
    • Multipotent mesenchymal stromal cells and the innate immune system
    • Le Blanc K. & Mougiakakos D. Multipotent mesenchymal stromal cells and the innate immune system. Nat. Rev. Immunol. 12, 383-396 (2012).
    • (2012) Nat. Rev. Immunol , vol.12 , Issue.383-396
    • Le Blanc, K.1    Mougiakakos, D.2
  • 2
    • 84856973179 scopus 로고    scopus 로고
    • Mesenchymal stem/stromal cells (MSCs): Role as guardians of inflammation
    • Prockop D.J. & Oh J.Y. Mesenchymal stem/stromal cells (MSCs): role as guardians of inflammation. Mol. Ther. 20, 14-20 (2012).
    • (2012) Mol. Ther , vol.20 , Issue.14-20
    • Prockop, D.J.1    Oh, J.Y.2
  • 3
    • 50249158511 scopus 로고    scopus 로고
    • Mesenchymal stem cells in health and disease
    • Uccelli A., Moretta L. & Pistoia V. Mesenchymal stem cells in health and disease. Nat. Rev. Immunol. 8, 726-736 (2008).
    • (2008) Nat. Rev. Immunol , vol.8 , pp. 726-736
    • Uccelli, A.1    Moretta, L.2    Pistoia, V.3
  • 4
    • 38649105374 scopus 로고    scopus 로고
    • Mesenchymal stem cell-mediated immunosuppression occurs via concerted action of chemokines and nitric oxide
    • Demonstrated that the immunosuppressive function of MSCs is not constitutive but is instead' licensed' by inflammation
    • Ren G. et al. Mesenchymal stem cell-mediated immunosuppression occurs via concerted action of chemokines and nitric oxide. Cell Stem Cell 2, 141-150 (2 008). Demonstrated that the immunosuppressive function of MSCs is not constitutive but is instead ' licensed' by inflammation.
    • (2008) Cell Stem Cell , vol.2 , pp. 141-150
    • Ren, G.1
  • 5
    • 0141561872 scopus 로고    scopus 로고
    • Regeneration and gene regulation in planarians
    • Agata K. Regeneration and gene regulation in planarians. Curr. Opin. Genet. Dev. 13, 492-496 (2003).
    • (2003) Curr. Opin. Genet. Dev , vol.13 , pp. 492-496
    • Agata, K.1
  • 6
    • 1542328965 scopus 로고    scopus 로고
    • Plasticity of adult stem cells
    • Wagers A.J. & Weissman I.L. Plasticity of adult stem cells. Cell 116, 639-648 (2004).
    • (2004) Cell , vol.116 , pp. 639-648
    • Wagers, A.J.1    Weissman, I.L.2
  • 7
    • 84989485234 scopus 로고
    • The development of fibroblast colonies in monolayer cultures of guinea-pig bone marrow and spleen cells
    • Friedenstein A.J., Chailakhjan R.K. & L alykina K.S. The development of fibroblast colonies in monolayer cultures of guinea-pig bone marrow and spleen cells. Cell Tissue Kinet. 3, 393-403 (1970).
    • (1970) Cell Tissue Kinet , vol.3 , pp. 393-403
    • Friedenstein, A.J.1    Chailakhjan, R.K.2    Alykina K S, L.3
  • 8
    • 84872088799 scopus 로고    scopus 로고
    • The meaning, the sense and the significance: Translating the science of mesenchymal stem cells into medicine
    • Bianco P. et al. The meaning, the sense and the significance: translating the science of mesenchymal stem cells into medicine. Nat. Med. 19, 35-42 (2013).
    • (2013) Nat. Med , vol.19 , Issue.35-42
    • Bianco, P.1
  • 9
    • 0026228558 scopus 로고
    • Mesenchymal stem cells
    • Caplan A.I. Mesenchymal stem cells. J. Orthop. Res. 9, 641-650 (1991).
    • (1991) J. Orthop. Res , vol.9 , pp. 641-650
    • Caplan, A.I.1
  • 10
    • 0033515827 scopus 로고    scopus 로고
    • Multilineage potential of adult human mesenchymal stem cells
    • Pittenger M.F. et al. Multilineage potential of adult human mesenchymal stem cells. Science 284, 143-147 (1999).
    • (1999) Science , vol.284 , pp. 143-147
    • Pittenger, M.F.1
  • 11
    • 0037019337 scopus 로고    scopus 로고
    • Pluripotency of mesenchymal stem cells derived from adult marrow
    • Jiang Y. et al. Pluripotency of mesenchymal stem cells derived from adult marrow. Nature 418, 41-49 (2002).
    • (2002) Nature , vol.418 , pp. 41-49
    • Jiang, Y.1
  • 12
    • 41549139755 scopus 로고    scopus 로고
    • Mesenchymal stem cells: Revisiting history, concepts, and assays
    • Bianco P., Robey P.G. & Simmons P.J. Mesenchymal stem cells: revisiting history, concepts, and assays. Cell Stem Cell 2, 313-319 (2008).
    • (2008) Cell Stem Cell , vol.2 , pp. 313-319
    • Bianco, P.1    Robey, P.G.2    Simmons, P.J.3
  • 13
    • 84862534451 scopus 로고    scopus 로고
    • Mesenchymal st romal cells new directions
    • Keating A. Mesenchymal st romal cells: new directions. Cell Stem Cell 10, 709-716 (2012).
    • (2012) Cell Stem Cell , vol.10 , Issue.709-716
    • Keating, A.1
  • 14
    • 27944435821 scopus 로고    scopus 로고
    • Clarification of the nomenclature for MSC: The International Society for Cellular Therapy position statement
    • Horwitz E.M. et al. Clarification of the nomenclature for MSC: The International Society for Cellular Therapy position statement. Cytotherapy 7, 393-395 (2005).
    • (2005) Cytotherapy , vol.7 , pp. 393-395
    • Horwitz, E.M.1
  • 15
    • 84880687861 scopus 로고    scopus 로고
    • Depletion of stromal cells expressing fibroblast activation protein-alpha from skeletal muscle and bone marrow results in cachexia and anemia
    • Roberts E.W. et al. Depletion of stromal cells expressing fibroblast activation protein-alpha from skeletal muscle and bone marrow results in cachexia and anemia. J. Exp. Med. 210, 1137-1151 (2013).
    • (2013) J. Exp. Med , vol.210 , pp. 1137-1151
    • Roberts, E.W.1
  • 16
    • 84893749179 scopus 로고    scopus 로고
    • Secretion of shh by a neurovascular bundle niche supports mesenchymal stem cell homeostasis in the adult mouse incisor
    • Zhao H. et al. Secretion of shh by a neurovascular bundle niche supports mesenchymal stem cell homeostasis in the adult mouse incisor. Cell Stem Cell 14, 160-173 (2014).
    • (2014) Cell Stem Cell , vol.14 , Issue.160-173
    • Zhao, H.1
  • 17
    • 77955646193 scopus 로고    scopus 로고
    • Mesenchymal and haematopoietic stem cells form a unique bone marrow niche
    • Demonstrated that nestin-positive cells in bone marrow act functionally like MSCs and constitute the HSC niche
    • Mé ndez-Ferrer S. et al. Mesenchymal and haematopoietic stem cells form a unique bone marrow niche. Nature 466, 829-834 (2010). Demonstrated that nestin-positive cells in bone marrow act functionally like MSCs and constitute the HSC niche.
    • (2010) Nature , vol.466 , Issue.829-834
    • Mé Ndez-Ferrer, S.1
  • 18
    • 84905861462 scopus 로고    scopus 로고
    • Leptin-receptor-expressing mesenchymal stromal cells re present the main source of bone formed by adult bone marrow
    • Zhou B.O. Yue R. Murphy M.M. Peyer J.G. Morrison S.J. Leptin-receptor-expressing mesenchymal stromal cells re present the main source of bone formed by adult bone marrowi Cell Stem Cell 15 154-168 2014).
    • (2014) Cell Stem Cell , vol.15 , Issue.154-168
    • Zhou, B.O.1    Yue, R.2    Murphy, M.M.3    Peyer, J.G.4    Morrison, S.J.5
  • 19
    • 33845445939 scopus 로고    scopus 로고
    • Maintenance of the hematopoietic s tem cell pool by CXCL12-CXCR4 chemokine signaling in bone marrow stromal cell niches
    • Sugiyama T., Kohara H., Noda M. & Nagasawa T. Maintenance of the hematopoietic s tem cell pool by CXCL12-CXCR4 chemokine signaling in bone marrow stromal cell niches. Immunity 25, 977-988 (2006).
    • (2006) Immunity , vol.25 , pp. 977-988
    • Sugiyama, T.1    Kohara, H.2    Noda, M.3    Nagasawa, T.4
  • 20
    • 84872026216 scopus 로고    scopus 로고
    • Concise review: Mesenchymal stem cells and translational medicine: Emerging issues
    • Ren G. et al. Concise review: mesenchymal stem cells and translational medicine: emerging issues. Stem Cells Transl Med 1, 51-58 (2012).
    • (2012) Stem Cells Transl Med , vol.1 , Issue.51-58
    • Ren, G.1
  • 21
    • 84901261243 scopus 로고    scopus 로고
    • Functional effects of TGF-?1 on mesenchymal stem cell mobilization in cockroach allergen-induced asthma
    • Gao P. et al. Functional effects of TGF-?1 on mesenchymal stem cell mobilization in cockroach allergen-induced asthma. J. Immunol. 192, 4560-4570 (2014).
    • (2014) J. Immunol , vol.192 , pp. 4560-4570
    • Gao, P.1
  • 22
    • 53049105000 scopus 로고    scopus 로고
    • Bone marrow mesenchymal stem cells ameliorate rat acute renal failure by differentiation into renal tubular epithelial-like cells
    • Qian H. et al. Bone marrow mesenchymal stem cells ameliorate rat acute renal failure by differentiation into renal tubular epithelial-like cells. Int. J. Mol. Med. 22, 325-332 (2008).
    • (2008) Int. J. Mol. Med , vol.22 , pp. 325-332
    • Qian, H.1
  • 23
    • 67549113627 scopus 로고    scopus 로고
    • Mesenchymal stem cells showed the highest potential for the regeneration of injured liver tissue compared with other subpopulations of the bone marrow
    • Cho K.A. et al. Mesenchymal stem cells showed the highest potential for the regeneration of injured liver tissue compared with other subpopulations of the bone marrow. Cell Biol. Int. 33, 772-777 (2009).
    • (2009) Cell Biol. Int , vol.33 , pp. 772-777
    • Cho, K.A.1
  • 24
    • 84865090506 scopus 로고    scopus 로고
    • Contribution of murine bone marrow mesenchymal stem cells to pancreas regeneration after partial pancreatectomy in mice
    • Han F. et al. Contribution of murine bone marrow mesenchymal stem cells to pancreas regeneration after partial pancreatectomy in mice. Cell Biol. Int. 36, 823-831 (2012).
    • (2012) Cell Biol. Int , vol.36 , Issue.823-831
    • Han, F.1
  • 25
    • 56249148884 scopus 로고    scopus 로고
    • Bone marrow-derived mesenchymal stromal cells express cardiac-specific markers, retain the stromal phenotype, and do not become functional cardiomyocytes in vitro
    • Rose R.A. et al. Bone marrow-derived mesenchymal stromal cells express cardiac-specific markers, retain the stromal phenotype, and do not become functional cardiomyocytes in vitro. Stem Cells 26, 2884-2892 (2008).
    • (2008) Stem Cells , vol.26 , pp. 2884-2892
    • Rose, R.A.1
  • 26
    • 78649379248 scopus 로고    scopus 로고
    • Evolving paradigms for repair of tissues by adult stem/progenitor cells (MSCs
    • Prockop D.J., Kota D.J., Bazhanov N. & Reger R.L. Evolving paradigms for repair of tissues by adult stem/progenitor cells (MSCs). J. Cell. Mol. Med. 14, 2190-2199 (2010).
    • (2010) J. Cell. Mol. Med , vol.14 , pp. 2190-2199
    • Prockop, D.J.1    Kota, D.J.2    Bazhanov, N.3    Reger, R.L.4
  • 27
    • 84862835586 scopus 로고    scopus 로고
    • Analysis of tissues following mesenchymal stromal cell therapy in humans indicates limited long-term engraftment and no ectopic tissue formation
    • von Bahr L. et al. Analysis of tissues following mesenchymal stromal cell therapy in humans indicates limited long-term engraftment and no ectopic tissue formation. Stem Cells 30, 1575-1578 (2012).
    • (2012) Stem Cells , vol.30 , pp. 1575-1578
    • Von Bahr, L.1
  • 28
    • 20844440562 scopus 로고    scopus 로고
    • Administered mesenchymal stem cells protect against ischemic acute renal failure through differentiation-independent mechanisms
    • Tö gel F. et al. Administered mesenchymal stem cells protect against ischemic acute renal failure through differentiation-independent mechanisms. Am. J. Physiol. Renal Physiol. 289, F31-F42 (2005).
    • (2005) Am. J. Physiol. Renal Physiol , vol.289 , pp. F31-F42
    • Tö Gel, F.1
  • 29
    • 10644226862 scopus 로고    scopus 로고
    • Transplantation of bone marrow cells reduces CCl4-induced liver fibrosis in mice
    • Sakaida I. et al. Transplantation of bone marrow cells reduces CCl4-induced liver fibrosis in mice. Hepatology 40, 1304-1311 (2004).
    • (2004) Hepatology , vol.40 , pp. 1304-1311
    • Sakaida, I.1
  • 30
    • 67649171661 scopus 로고    scopus 로고
    • Intravenous hMSCs improve my ocardial infarction in mice because cells embolized in lung are activated to secrete the anti-inflammatory protein TSG-6
    • Showed that intravenous infusion of human MSCs improves myocardial infarction in mice via TSG6 and that TSG6 alone is sufficient to provide the therapeutic effect
    • Lee R.H. et al. Intravenous hMSCs improve my ocardial infarction in mice because cells embolized in lung are activated to secrete the anti-inflammatory protein TSG-6. Cell Stem Cell 5, 54-63 (2009) Showed that intravenous infusion of human MSCs improves myocardial infarction in mice via TSG6 and that TSG6 alone is sufficient to provide the therapeutic effect.
    • (2009) Cell Stem Cell , vol.5 , pp. 54-63
    • Lee, R.H.1
  • 31
    • 84861574208 scopus 로고    scopus 로고
    • Hepatocyte growth factor mediates mesenchymal stem cell-induced recovery in multiple sclerosis models
    • Bai L. et al. Hepatocyte growth factor mediates mesenchymal stem cell-induced recovery in multiple sclerosis models. Nat. Neurosci. 15, 862-870 (2012).
    • (2012) Nat. Neurosci , vol.15 , Issue.862-870
    • Bai, L.1
  • 32
    • 61649104033 scopus 로고    scopus 로고
    • Regenerative capacity of intravenous autologous, allogeneic and human mesenchymal stem cells in the infarcted pig myocardium-complicated by myocardial tumor formation
    • Wolf D. et al. Regenerative capacity of intravenous autologous, allogeneic and human mesenchymal stem cells in the infarcted pig myocardium-complicated by myocardial tumor formation . Scand. Cardiovasc. J. 43, 39-45 (2009).
    • (2009) Scand. Cardiovasc. J , vol.43 , pp. 39-45
    • Wolf, D.1
  • 33
    • 84892433295 scopus 로고    scopus 로고
    • Immunobiology of mesenchymal stem cells
    • Ma S. et al. Immunobiology of mesenchymal stem cells. Cell Death Differ. 21, 216-225 (2014).
    • (2014) Cell Death Differ , vol.21 , Issue.216-225
    • Ma, S.1
  • 34
    • 84857838864 scopus 로고    scopus 로고
    • Harnessing the mesenchymal stem cell secretome for the treatment of cardiovascular disease
    • Ranganath S. H., Levy O., Inamdar M.S. & Karp J.M. Harnessing the mesenchymal stem cell secretome for the treatment of cardiovascular disease. Cell Stem Cell 10, 244-258 (2012).
    • (2012) Cell Stem Cell , vol.10 , Issue.244-258
    • Ranganath, S.H.1    Levy, O.2    Inamdar, M.S.3    Karp, J.M.4
  • 35
    • 0037093058 scopus 로고    scopus 로고
    • Human bone marrow stromal cells suppress T-lymphocyte proliferation induced by cellular or nonspecific mitogenic stimuli
    • Di Nicola, M . et al. Human bone marrow stromal cells suppress T-lymphocyte proliferation induced by cellular or nonspecific mitogenic stimuli. Blood 99, 3838-3843 (2002).
    • (2002) Blood , vol.99 , pp. 3838-3843
    • Di Nicola, M.1
  • 36
    • 0036142769 scopus 로고    scopus 로고
    • Mesenchy mal stem cells suppress lymphocyte proliferation in vitro and prolong skin graft survival in vivo
    • Bartholomew A. et al. Mesenchy mal stem cells suppress lymphocyte proliferation in vitro and prolong skin graft survival in vivo. Exp. Hematol. 30, 42-48 (2002).
    • (2002) Exp. Hematol , vol.30 , pp. 42-48
    • Bartholomew, A.1
  • 38
    • 84857684777 scopus 로고    scopus 로고
    • How mesenchymal stem cells interact with tissue immune responses
    • Shi Y. et al. How mesenchymal stem cells interact with tissue immune responses. Trends Immunol. 33, 136-143 (2012).
    • (2012) Trends Immunol , vol.33 , Issue.136-143
    • Shi, Y.1
  • 39
    • 84885099905 scopus 로고    scopus 로고
    • Mesenchymal stromal cells: Sensors and switchers of inflammation
    • Bernardo M.E. Fibbe W.E. Mesenchymal stromal cells: sensors and switchers of inflammation Cell Stem Cell 13 392-402 2013).
    • (2013) Cell Stem Cell , vol.13 , Issue.392-402
    • Bernardo, M.E.1    Fibbe, W.E.2
  • 40
    • 84878401681 scopus 로고    scopus 로고
    • Mesenchymal stem cells generate a CD4+CD25+Foxp3+ regulatory T cell population during the differentiation process of Th1 and Th17 cells
    • Luz-Crawford P. et al. Mesenchymal stem cells generate a CD4+CD25+Foxp3+ regulatory T cell population during the differentiation process of Th1 and Th17 cells. Stem Cell Res. Ther. 4, 65 (2013).
    • (2013) Stem Cell Res. Ther , vol.4 , Issue.65
    • Luz-Crawford, P.1
  • 41
    • 84906545300 scopus 로고    scopus 로고
    • Umbilical cord-derived mesenchymal stem cells instruct dendritic cells to acquire tolerogenic phenotypes through the IL-6-mediated upregulation of SOCS1
    • Deng Y. et al. Umbilical cord-derived mesenchymal stem cells instruct dendritic cells to acquire tolerogenic phenotypes through the IL-6-mediated upregulation of SOCS1. Stem Cells Dev. 23, 2080-2092 (2014).
    • (2014) Stem Cells Dev , vol.23 , pp. 2080-2092
    • Deng, Y.1
  • 42
    • 84860636948 scopus 로고    scopus 로고
    • Mesenchymal-stem-cell-induced immunoregulation involves FAS-ligand-/FAS-mediated T cell apoptosis
    • Akiyama K. et al. Mesenchymal-stem-cell-induced immunoregulation involves FAS-ligand-/FAS-mediated T cell apoptosis. Cell Stem Cell 10, 544-555 (2012).
    • (2012) Cell Stem Cell , vol.10 , Issue.544-555
    • Akiyama, K.1
  • 43
    • 58149326737 scopus 로고    scopus 로고
    • Bone marrow stromal cells attenuate sepsis via prostaglandin E2-dependent reprogramming of host macrophages to increase their interleukin-10 production
    • Németh K. et al. Bone marrow stromal cells attenuate sepsis via prostaglandin E2-dependent reprogramming of host macrophages to increase their interleukin-10 production. Nat. Med. 15, 42-49 (2009).
    • (2009) Nat. Med , vol.15 , pp. 42-49
    • Németh, K.1
  • 44
    • 84884814863 scopus 로고    scopus 로고
    • Human placental mesenchymal stem cells (pMSCs) play a role as immune suppressive cells by shifting macrophage differentiation from inflammatory M1 to anti-inflammatory M2 macrophages
    • Abumaree M.H. et al. Human placental mesenchymal stem cells (pMSCs) play a role as immune suppressive cells by shifting macrophage differentiation from inflammatory M1 to anti-inflammatory M2 macrophages. Stem Cell Rev. 9, 620-641 (2013).
    • (2013) Stem Cell Rev , vol.9 , Issue.620-641
    • Abumaree, M.H.1
  • 45
    • 32644438233 scopus 로고    scopus 로고
    • Mesenchymal stem cell-natural killer cell interactions: Evidence that activated NK cells are capable of killing MSCs, wher eas MSCs can inhibit IL-2-induced NK-cell proliferation
    • Spaggiari G.M., Capobianco A., Becchetti S., Mingari M.C. & Moretta L. Mesenchymal stem cell-natural killer cell interactions: evidence that activated NK cells are capable of killing MSCs, wher eas MSCs can inhibit IL-2-induced NK-cell proliferation. Blood 107, 1484-1490 (2006).
    • (2006) Blood , vol.107 , pp. 1484-1490
    • Spaggiari, G.M.1    Capobianco, A.2    Becchetti, S.3    Mingari, M.C.4    Moretta, L.5
  • 46
    • 38949183675 scopus 로고    scopus 로고
    • Mesenchymal stem cells inhibit natural killer-cell proliferation, cytotoxicity, and cytoki ne production: Role of indoleamine 2,3-dioxygenase and prostaglandin E2
    • Spaggiari G.M. et al. Mesenchymal stem cells inhibit natural killer-cell proliferation, cytotoxicity, and cytoki ne production: role of indoleamine 2,3-dioxygenase and prostaglandin E2. Blood 111, 1327-1333 (2008).
    • (2008) Blood , vol.111 , pp. 1327-1333
    • Spaggiari, G.M.1
  • 47
    • 77950377767 scopus 로고    scopus 로고
    • Bone marrow stromal cells use TGF-? to suppress allergic responses in a mouse model of ragweed-induced asthma
    • Nemeth K. et al. Bone marrow stromal cells use TGF-? to suppress allergic responses in a mouse model of ragweed-induced asthma. Proc. Natl. Acad. Sci. USA 107, 5652-5657 (2010).
    • (2010) Proc. Natl. Acad. Sci. USA , vol.107 , pp. 5652-5657
    • Nemeth, K.1
  • 48
    • 73349122308 scopus 로고    scopus 로고
    • Requirement of IFN-gamma-mediated indoleamine 2,3-dioxygenase expression in the modulation of l ymphocyte proliferation by human adipose-derived stem cells
    • DelaRosa O. et al. Requirement of IFN-gamma-mediated indoleamine 2,3-dioxygenase expression in the modulation of l ymphocyte proliferation by human adipose-derived stem cells. Tissue Eng. Part A 15, 2795-2806 (2009).
    • (2009) Tissue Eng. Part A , vol.15 , pp. 2795-2806
    • Delarosa, O.1
  • 49
    • 34547402979 scopus 로고    scopus 로고
    • Interleukin 1 receptor antagonist mediates the antiinflammatory and antifibrot ic effect of mesenchymal stem cells during lung injury
    • Ortiz L.A. et al. Interleukin 1 receptor antagonist mediates the antiinflammatory and antifibrot ic effect of mesenchymal stem cells during lung injury. Proc. Natl. Acad. Sci. USA 104, 11002-11007 (2007).
    • (2007) Proc. Natl. Acad. Sci. USA , vol.104 , pp. 11002-11007
    • Ortiz, L.A.1
  • 50
    • 69249227552 scopus 로고    scopus 로고
    • MSCs inhibit monocyte-d erived DC maturation and function by selectively interfering with the generation of immature DCs: Central role of MSC-derived prostaglandin E2
    • Spaggiari G.M., Abdelrazik H., Becchetti F. & Moretta L. MSCs inhibit monocyte-d erived DC maturation and function by selectively interfering with the generation of immature DCs: central role of MSC-derived prostaglandin E2. Blood 113, 6576-6583 (2009).
    • (2009) Blood , vol.113 , pp. 6576-6583
    • Spaggiari, G.M.1    Abdelrazik, H.2    Becchetti, F.3    Moretta, L.4
  • 51
    • 70349881103 scopus 로고    scopus 로고
    • Mesenchymal stromal cells ameliorate experimental autoimmune encephalomyelitis by inhibiting CD4 Th17 T cells in a CC chemokine ligand 2-dependent manner
    • Rafei M. et al. Mesenchymal stromal cells ameliorate experimental autoimmune encephalomyelitis by inhibiting CD4 Th17 T cells in a CC chemokine ligand 2-dependent manner. J. Immunol. 182, 5994-6002 (2009).
    • (2009) J. Immunol , vol.182 , pp. 5994-6002
    • Rafei, M.1
  • 52
    • 33746889097 scopus 로고    scopus 로고
    • Role for interferon-? in the immunomodulatory activity of human bone marrow mesenchymal stem cells
    • Krampera M. et al. Role for interferon-? in the immunomodulatory activity of human bone marrow mesenchymal stem cells. Stem Cells 24, 386-398 (2006).
    • (2006) Stem Cells , vol.24 , pp. 386-398
    • Krampera, M.1
  • 53
    • 34548833007 scopus 로고    scopus 로고
    • Human multipotent mesenchymal stromal cells inhibit proliferation of PBMCs independently of IFN?R1 signaling and IDO expression
    • Gieseke F. et a l. Human multipotent mesenchymal stromal cells inhibit proliferation of PBMCs independently of IFN?R1 signaling and IDO expression. Blood 110, 2197-2200 (2007).
    • (2007) Blood , vol.110 , pp. 2197-2200
    • Gieseke, F.1
  • 54
    • 69249119079 scopus 로고    scopus 로고
    • Species variation in the mechanisms of mesenchymal stem cell-mediated immunosuppression
    • Ren G. et al. Species variation in the mechanisms of mesenchymal stem cell-mediated immunosuppression. Stem Cells 27, 1954-1962 (2009).
    • (2009) Stem Cells , vol.27 , pp. 1954-1962
    • Ren, G.1
  • 55
    • 84893824227 scopus 로고    scopus 로고
    • Phylogenetic distin ction of iNOS and IDO function in mesenchymal stem cell-mediated immunosuppression in mammalian species
    • Su J. et al. Phylogenetic distin ction of iNOS and IDO function in mesenchymal stem cell-mediated immunosuppression in mammalian species. Cell Death Differ. 21, 388-396 (2014).
    • (2014) Cell Death Differ , vol.21 , Issue.388-396
    • Su, J.1
  • 56
    • 84896503768 scopus 로고    scopus 로고
    • Mesenchymal stem cells use IDO to regulate immunity in tumor microenvironment
    • Ling W. et al. Mesenchymal stem cells use IDO to regulate immunity in tumor microenvironment. Cancer Res. 74, 1576-1587 (2014).
    • (2014) Cancer Res , vol.74 , pp. 1576-1587
    • Ling, W.1
  • 57
    • 77956420421 scopus 로고    scopus 로고
    • A new mesenchymal stem cell (MSC) p aradigm: Polarization into a pro-inflammatory MSC1 or an Immunosuppressive MSC2 phenotype
    • Proposed the concept of proinflammatory (MSC1) and anti-inflammatory (MSC2) phenotypes of MSCs and demonstrated difference s in their induction by TLR ligands
    • Waterman R.S., Tomchuck S.L., Henkle S.L. & Betancourt A.M. A new mesenchymal stem cell (MSC) p aradigm: polarization into a pro-inflammatory MSC1 or an Immunosuppressive MSC2 phenotype. PLoS ONE 5, e10088 (2010)Proposed the concept of proinflammatory (MSC1) and anti-inflammatory (MSC2) phenotypes of MSCs and demonstrated difference s in their induction by TLR ligands.
    • (2010) PLoS ONE , vol.5 , pp. e10088
    • Waterman, R.S.1    Tomchuck, S.L.2    Henkle, S.L.3    Betancourt, A.M.4
  • 58
    • 33744917000 scopus 로고    scopus 로고
    • Bone marrow mesenchymal stem cells suppress lymphocyte proliferation in vitro but fail to prevent graft-versus-host disease in mice
    • Sudres M. et al. Bone marrow mesenchymal stem cells suppress lymphocyte proliferation in vitro but fail to prevent graft-versus-host disease in mice. J. Immunol. 176, 7761-7767 (2006).
    • (2006) J. Immunol , vol.176 , pp. 7761-7767
    • Sudres, M.1
  • 59
    • 70350212973 scopus 로고    scopus 로고
    • Adipose-derived mesenchymal stem cells ameliorate chronic experimental autoimmune encephalomyelitis
    • Constantin G. et al. Adipose-derived mesenchymal stem cells ameliorate chronic experimental autoimmune encephalomyelitis. Stem Cells 27, 2624-2635 (2009).
    • (2009) Stem Cells , vol.27 , pp. 2624-2635
    • Constantin, G.1
  • 60
    • 84865184497 scopus 로고    scopus 로고
    • Mesenchymal stem cells: A double-edged sword in regulating immune responses
    • Li W. et al. Mesenchymal stem cells: a double-edged sword in regulating immune responses. Cell Death Differ. 19, 1505-1513 (2012).
    • (2012) Cell Death Differ , vol.19 , pp. 1505-1513
    • Li, W.1
  • 61
    • 68949199491 scopus 로고    scopus 로고
    • Mesenchymal stem cells require a sufficient, ongoing immune response to exert their immunosuppressive function
    • Renner P. et al. Mesenchymal stem cells require a sufficient, ongoing immune response to exert their immunosuppressive function. Transplant. Proc. 41, 2607-2611 (2009).
    • (2009) Transplant. Proc , vol.41 , pp. 2607-2611
    • Renner, P.1
  • 62
    • 33745076513 scopus 로고    scopus 로고
    • Antigen-presenting property of mesenchymal stem cells occurs during a narrow window at low levels of interferon-?
    • Chan J.L. et al. Antigen-presenting property of mesenchymal stem cells occurs during a narrow window at low levels of interferon-?. Blood 107, 4817-4824 (2006).
    • (2006) Blood , vol.107 , pp. 4817-4824
    • Chan, J.L.1
  • 63
    • 70350512378 scopus 로고    scopus 로고
    • Mesenchymal stromal cells cross-present soluble exogenous antigens as part of their antigen-presenting cell properties
    • Franç ois M. et al. Mesenchymal stromal cells cross-present soluble exogenous antigens as part of their antigen-presenting cell properties. Blood 114, 2632-2638 (2009).
    • (2009) Blood , vol.114 , pp. 2632-2638
    • Franç Ois, M.1
  • 64
    • 82255191977 scopus 로고    scopus 로고
    • TLR-dependent T cell activation in autoimmunity
    • Mills K.H. TLR-dependent T cell activation in autoimmunity. Nat. Rev. Immunol. 11, 807-822 (2011).
    • (2011) Nat. Rev. Immunol , vol.11 , Issue.807-822
    • Mills, K.H.1
  • 65
    • 84932176456 scopus 로고    scopus 로고
    • Interleukin-17 enhances immunosuppression by mesenchymal stem cells
    • Han X. et al. Interleukin-17 enhances immunosuppression by mesenchymal stem cells. Cell Death Differ. doi:10.1038/cdd.2014.85 (2014).
    • (2014) Cell Death Differ
    • Han, X.1
  • 66
    • 41549169557 scopus 로고    scopus 로고
    • Contextual regulation of inflammation: A duet by transforming growth factor-? and interleukin-10
    • Li M.O. & Flavell R.A. Contextual regulation of inflammation: a duet by transforming growth factor-? and interleukin-10. Immunity 28, 468-476 (2008).
    • (2008) Immunity , vol.28 , pp. 468-476
    • Li, M.O.1    Flavell, R.A.2
  • 67
    • 77955162737 scopus 로고    scopus 로고
    • Mechanical load modulates ch ondrogenesis of human mesenchymal stem cells through the TGF-pathway
    • Li Z., Kupcsik L., Yao S.J., Alini M. & Stoddart M.J. Mechanical load modulates ch ondrogenesis of human mesenchymal stem cells through the TGF-? pathway. J. Cell. Mol. Med. 14, 1338-1346 (2010).
    • (2010) J. Cell. Mol. Med , vol.14 , pp. 1338-1346
    • Li, Z.1    Kupcsik, L.2    Yao, S.J.3    Alini, M.4    Stoddart, M.J.5
  • 68
    • 84893845161 scopus 로고    scopus 로고
    • Bone marrow mesenchymal stem cells and TGF-beta signaling in bone remodeling
    • Crane J.L. & Cao X. Bone marrow mesenchymal stem cells and TGF-beta signaling in bone remodeling. J. Clin. Invest. 124, 466-472 (2014).
    • (2014) J. Clin. Invest , vol.124 , Issue.466-472
    • Crane, J.L.1    Cao, X.2
  • 69
    • 84891074677 scopus 로고    scopus 로고
    • TGF-promot es immune responses in the presence of mesenchymal stem cells
    • Demonstrated that MSC-mediated immunosuppression of T cells can be reversed by TGF-b, a well-known immunosuppressive cytokine
    • Xu C. et al. TGF-? promot es immune responses in the presence of mesenchymal stem cells. J. Immunol. 192, 103-109 (2014). Demonstrated that MSC-mediated immunosuppression of T cells can be reversed by TGF-b, a well-known immunosuppressive cytokine.
    • (2014) J. Immunol , vol.192 , pp. 103-109
    • Xu, C.1
  • 70
    • 76949094176 scopus 로고    scopus 로고
    • Inflammation modifies the pattern and the function of Toll-like receptors expressed by human mesenchymal stromal cells
    • Raicevic G. et al. Inflammation modifies the pattern and the function of Toll-like receptors expressed by human mesenchymal stromal cells. Hum. Immunol. 71, 235-244 (2010).
    • (2010) Hum. Immunol , vol.71 , Issue.235-244
    • Raicevic, G.1
  • 71
    • 33745144672 scopus 로고    scopus 로고
    • Immunomodulatory effects of mesenchymal stem cells in a rat organ transplant model
    • Showed that concurrent administration of MSCs with a low dose of cyclosporin A accelera tes allograft rejection
    • I noue S. et al. Immunomodulatory effects of mesenchymal stem cells in a rat organ transplant model. Transplantation 81, 1589-1595 (2006). Showed that concurrent administration of MSCs with a low dose of cyclosporin A accelera tes allograft rejection.
    • (2006) Transplantation , vol.81 , pp. 1589-1595
    • Inoue, S.1
  • 72
    • 84906911104 scopus 로고    scopus 로고
    • The interaction between mesenchymal stem cells and steroids during inflammation
    • Chen X. et al. The interaction between mesenchymal stem cells and steroids during inflammation. Cell Death Dis 5, e1009 (2014).
    • (2014) Cell Death Dis , vol.5 , pp. e1009
    • Chen, X.1
  • 73
    • 84872168547 scopus 로고    scopus 로고
    • Mesenchymal stromal cells and regulatory T cells: The Yin and Yang of peripheral tolerance? Immunol
    • Burr S.P., Dazzi F. & Garden O.A. Mesenchymal stromal cells and regulatory T cells: the Yin and Yang of peripheral tolerance? Immunol. Cell Biol. 91, 12-18 (2013).
    • (2013) Cell Biol , vol.91 , Issue.12-18
    • Burr, S.P.1    Dazzi, F.2    Garden, O.A.3
  • 74
    • 2342482526 scopus 로고    scopus 로고
    • Treatment o f severe acute graft-versus-host disease with third party haploidentical mesenchymal stem cells
    • First report of a clinical application of MSCs in treating acute steroid-resistant GvHD
    • Le Blanc K. et al. Treatment o f severe acute graft-versus-host disease with third party haploidentical mesenchymal stem cells. Lancet 363, 1439-1441 (2004). First report of a clinical application of MSCs in treating acute steroid-resistant GvHD.
    • (2004) Lancet , vol.363 , pp. 1439-1441
    • Le Blanc, K.1
  • 75
    • 84870887067 scopus 로고    scopus 로고
    • Comparison of allogeneic vs autologous bone marrow-derived mesenchymal stem cells delivered by transendocardial injection in patients with ischemic cardiomyopathy: The POSEIDON randomized trial
    • Hare J.M. et al. Comparison of allogeneic vs autologous bone marrow-derived mesenchymal stem cells delivered by transendocardial injection in patients with ischemic cardiomyopathy: the POSEIDON randomized trial. J. Am. Med. Assoc. 3 08, 2369-2379 (2012).
    • (2012) J. Am. Med. Assoc , vol.308 , pp. 2369-2379
    • Hare, J.M.1
  • 76
    • 84863049034 scopus 로고    scopus 로고
    • Human umbilical cord mesenchymal stem cells improve liver function and ascites in decompensated liver cirrhosis patients
    • Zhang Z. et al. Human umbilical cord mesenchymal stem cells improve liver function and ascites in decompensated liver cirrhosis patients. J. Gastroenterol. Hepatol. 27 (suppl. 2), 112-120 (2012).
    • (2012) J. Gastroenterol. Hepatol , vol.27 , pp. 112-120
    • Zhang, Z.1
  • 77
    • 43049103438 scopus 로고    scopus 로고
    • Mesenchymal stem cells for treatment of steroid-resistant, severe, acute graft-versus-host disease: A phase II study
    • Le Blanc K. et al. Mesenchymal stem cells for treatment of steroid-resistant, severe, acute graft-versus-host disease: a phase II study. Lancet 371, 1579-1586 (2008).
    • (2008) Lancet , vol.371 , pp. 1579-1586
    • Le Blanc, K.1
  • 78
    • 77955361735 scopus 로고    scopus 로고
    • Umbilical cord mesenchymal stem cell transplantation in severe and refractory systemic lupus erythematosus
    • Sun L. et al. Umbilical cord mesenchymal stem cell transplantation in severe and refractory systemic lupus erythematosus. Arthritis Rheum. 62, 2467-2475 (2010).
    • (2010) Arthritis Rheum , vol.62 , pp. 2467-2475
    • Sun, L.1
  • 79
    • 77956150674 scopus 로고    scopus 로고
    • Stem cells in the treatment of inflammatory arthritis
    • Tyndall A. & van Laar J.M. Stem cells in the treatment of inflammatory arthritis. Best Pract. Res. Clin. Rheumatol. 24, 565-574 (2010).
    • (2010) Best Pract. Res. Clin. Rheumatol , vol.24 , pp. 565-574
    • Tyndall, A.1    Van Laar, J.M.2
  • 80
    • 84881092225 scopus 로고    scopus 로고
    • Immunological characterization of multipotent mesenchymal stromal cells-The International Society for Cellular Therapy (ISCT) working proposal
    • Krampera M., Galipeau J., Shi Y., Tarte K. & Sensebe L. Immunological characterization of multipotent mesenchymal stromal cells-The International Society for Cellular Therapy (ISCT) working proposal. C ytotherapy 15, 1054-1061 (2013).
    • (2013) Cytotherapy , vol.15 , pp. 1054-1061
    • Krampera, M.1    Galipeau, J.2    Shi, Y.3    Tarte, K.4    Sensebe, L.5
  • 81
    • 80052487336 scopus 로고    scopus 로고
    • Mesenchymal stromal cell 'licensing ' a multistep process
    • Krampera M. Mesenchymal stromal cell 'licensing ': a multistep process. Leukemia 25, 1408-1414 (2011).
    • (2011) Leukemia , vol.25 , pp. 1408-1414
    • Krampera, M.1
  • 82
    • 84864319403 scopus 로고    scopus 로고
    • Role of mesenchymal stem cell therapy in Crohn's disease
    • Dalal J. Gandy K. Domen J Role of mesenchymal stem cell therapy in Crohn's disease Pediatr. Res. 71 445-451 2012).
    • (2012) Pediatr. Res , vol.71 , pp. 445-451
    • Dalal, J.1    Gandy, K.2    Domen, J.3
  • 83
    • 78149470554 scopus 로고    scopus 로고
    • Stem-cell drug fails crucial trials
    • Revealed that Prochymal (an MSC-based product) performed no more effectively than a placebo in a phase III clinical trial targeting GvHD; here, Prochym al was used together with steroid and that treatment was compared with steroid alone
    • Baker M. Stem-cell drug fails crucial trials. in Nature http://www.nature.com/news/2009/090909/full/news.2009.894.html (2009). Revealed that Prochymal (an MSC-based product) performed no more effectively than a placebo in a phase III clinical trial targeting GvHD; here, Prochym al was used together with steroid and that treatment was compared with steroid alone.
    • (2009) Nature
    • Baker, M.1
  • 84
    • 80053221596 scopus 로고    scopus 로고
    • Pretreatment with interferon-enhances the therapeutic activity of mesenchymal stromal cells in animal models of colitis
    • Duijvestein M. et al. Pretreatment with interferon-? enhances the therapeutic activity of mesenchymal stromal cells in animal models of colitis. Stem Cells 29, 1549-1558 (2011).
    • (2011) Stem Cells , vol.29 , pp. 1549-1558
    • Duijvestein, M.1
  • 85
    • 84857046728 scopus 로고    scopus 로고
    • Pretreating mesenchymal stem cells with interleukin-1 and transforming growth factor- synergistically increases vascular endothelia l growth factor production and improves mesenchymal stem cell-mediated myocardial protection after acute ischemia
    • Luo Y. et al. Pretreating mesenchymal stem cells with interleukin-1? and transforming growth factor-? synergistically increases vascular endothelia l growth factor production and improves mesenchymal stem cell-mediated myocardial protection after acute ischemia. Surgery 151, 353-363 (2012).
    • (2012) Surgery , vol.151 , pp. 353-363
    • Luo, Y.1
  • 86
    • 49649106257 scopus 로고    scopus 로고
    • IFN-activation of mesenchymal stem cells for treatment and prevention of graft versus host disease
    • Polchert D. et al. IFN-? activation of mesenchymal stem cells for treatment and prevention of graft versus host disease. Eur. J. Immunol. 38, 1745-1755 (2008).
    • (2008) Eur. J. Immunol , vol.38 , pp. 1745-1755
    • Polchert, D.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.