Damage-associated molecular patterns and immune activation in bipolar disorder

Acta Psychiatrica Scandinavica

Volumn 132, Issue 3, 2015, Pages 211-217

  Stertz, L ^a,b,c   Fries, G R ^a,b   Rosa, A R ^a,b   Kauer Sant'anna, M ^a,b   Ferrari, P ^b   Paz, A V C ^b   Green, C ^c   Cunha, A B M ^a,d   Dal Pizzol, F ^e   Gottfried, C ^a   Kapczinski, F ^b,c  

^a FEDERAL UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

^b HOSPITAL DE CLÍNICAS DE PORTO ALEGRE   (Brazil)

^c UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

^d FEDERAL UNIVERSITY OF SANTA MARIA   (Brazil)

^e Universidade do Extremo Sul Catarinense   (United States)

Author keywords

Acute mood episode; Bipolar disorder; Cell death; Circulating cell free DNA; Damage associated molecular patterns; Heat shock proteins

Indexed keywords

CELL NUCLEUS DNA; CHAPERONIN 60; HALOPERIDOL; HEAT SHOCK PROTEIN 70; HEAT SHOCK PROTEIN 90; HEAT SHOCK PROTEIN 90ALPHA; MITOCHONDRIAL DNA; NEUROLEPTIC AGENT; UNCLASSIFIED DRUG; BIOLOGICAL MARKER; DNA;

ADULT; AGED; ARTICLE; BIPOLAR DISORDER; CLINICAL ARTICLE; CONTROLLED STUDY; DAMAGE ASSOCIATED MOLECULAR PATTERN; DELIRIUM; DEPRESSION; DISORDERS OF MITOCHONDRIAL FUNCTIONS; FEMALE; FOLLOW UP; GLOBAL ASSESSMENT OF FUNCTIONING; HAMILTON DEPRESSION RATING SCALE; HUMAN; IMMUNE RESPONSE; MALE; MANIA; MIXED MANIA AND DEPRESSION; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; SEPSIS; STRUCTURED CLINICAL INTERVIEW FOR DSM DISORDERS; YOUNG MANIA RATING SCALE; BLOOD; CASE CONTROL STUDY; GENETICS; IMMUNOLOGY; MIDDLE AGED; MULTIVARIATE ANALYSIS; PERSONALIZED MEDICINE;

ADULT; AGED; BIOMARKERS; BIPOLAR DISORDER; CASE-CONTROL STUDIES; CHAPERONIN 60; DNA; FEMALE; HSP70 HEAT-SHOCK PROTEINS; HSP90 HEAT-SHOCK PROTEINS; HUMANS; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; PRECISION MEDICINE;

EID: 84938741413     PISSN: 0001690X     EISSN: 16000447     Source Type: Journal    
DOI: 10.1111/acps.12417     Document Type: Article

References (37)

1. Merikangas KR, Jin R, He JP et al. Prevalence and correlates of bipolar spectrum disorder in the world mental health survey initiative. Arch Gen Psychiatry 2011;68:241-251.
2. Soreca I, Frank E, Kupfer DJ. The phenomenology of bipolar disorder: what drives the high rate of medical burden and determines long-term prognosis? Depress Anxiety 2009;26:73-82.
3. Sanchez-Moreno J, Martinez-Aran A, Tabares-Seisdedos R, Torrent C, Vieta E, Ayuso-Mateos JL. Functioning and disability in bipolar disorder: an extensive review. Psychother Psychosom 2009;78:285-297.
4. Fiedorowicz JG, Palagummi NM, Forman-Hoffman VL, Miller DD, Haynes WG. Elevated prevalence of obesity, metabolic syndrome, and cardiovascular risk factors in bipolar disorder. Ann Clin Psychiatry 2008;20:131-137.
5. Magalhaes PV, Kapczinski F, Nierenberg AA et al. Illness burden and medical comorbidity in the Systematic Treatment Enhancement Program for Bipolar Disorder. Acta Psychiatr Scand 2012;125:303-308.
6. Kapczinski F, Dal-Pizzol F, Teixeira AL et al. Peripheral biomarkers and illness activity in bipolar disorder. J Psychiatr Res 2011;45:156-161.
7. Appay V, Sauce D. Immune activation and inflammation in HIV-1 infection: causes and consequences. J Pathol 2008;214:231-241.
8. Kauer-Sant'anna M, Kapczinski F, Andreazza AC et al. Brain-derived neurotrophic factor and inflammatory markers in patients with early- vs. late-stage bipolar disorder. Int J Neuropsychopharmacol 2009;12:447-458.
9. Leboyer M, Soreca I, Scott J et al. Can bipolar disorder be viewed as a multi-system inflammatory disease? J Affect Disord 2012;141:1-10.
10. Barbosa IG, Rocha NP, Bauer ME et al. Chemokines in bipolar disorder: trait or state? Eur Arch Psychiatry Clin Neurosci 2012;263:159-165.
11. Politi P, Brondino N, Emanuele E. Increased proapoptotic serum activity in patients with chronic mood disorders. Arch Med Res 2008;39:242-245.
12. Gigante AD, Young LT, Yatham LN et al. Morphometric post-mortem studies in bipolar disorder: possible association with oxidative stress and apoptosis. Int J Neuropsychopharmacol 2011;14:1075-1089.
13. Pfaffenseller B, Wollenhaupt-Aguiar B, Fries GR et al. Impaired endoplasmic reticulum stress response in bipolar disorder: cellular evidence of illness progression. Int J Neuropsychopharmacol 2014;17:1453-1463.
14. Fries GR, Vasconcelos-Moreno MP, Gubert C et al. Early apoptosis in peripheral blood mononuclear cells from patients with bipolar disorder. J Affect Disord 2014;152-154:474-477.
15. Kapczinski F, Dal-Pizzol F, Teixeira AL et al. A systemic toxicity index developed to assess peripheral changes in mood episodes. Mol Psychiatry 2010;15:784-786.
16. Stertz L, Magalhaes PV, Kapczinski F. Is bipolar disorder an inflammatory condition? The relevance of microglial activation. Curr Opin Psychiatry 2013;26:19-26.
17. Bone RC, Balk RA, Cerra FB et al. Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine. Chest 1992;101:1644-1655.
18. Young RC, Biggs JT, Ziegler VE, Meyer DA. A rating scale for mania: reliability, validity and sensitivity. Br J Psychiatry 1978;133:429-435.
19. Williams JB. A structured interview guide for the Hamilton Depression Rating Scale. Arch Gen Psychiatry 1988;45:742-747.
20. Jones SH, Thornicroft G, Coffey M, Dunn G. A brief mental health outcome scale-reliability and validity of the Global Assessment of Functioning (GAF). Br J Psychiatry 1995;166:654-659.
21. Xia P, Radpour R, Zachariah R et al. Simultaneous quantitative assessment of circulating cell-free mitochondrial and. Genet Mol Biol 2009;32:20-24.
22. Osborne JW. Improving your data transformations: applying the Box-Cox transformation. Prac Assess Res Eval 2010;15.
23. Wickman GR, Julian L, Mardilovich K et al. Blebs produced by actin-myosin contraction during apoptosis release damage-associated molecular pattern proteins before secondary necrosis occurs. Cell Death Differ 2013;20:1293-1305.
24. Jounai N, Kobiyama K, Takeshita F, Ishii KJ. Recognition of damage-associated molecular patterns related to nucleic acids during inflammation and vaccination. Front Cell Infect Microbiol 2012;2:168.
25. Xanthos DN, Sandkuhler J. Neurogenic neuroinflammation: inflammatory CNS reactions in response to neuronal activity. Nat Rev Neurosci 2014;15:43-53.
26. Tabas I, Glass CK. Anti-inflammatory therapy in chronic disease: challenges and opportunities. Science 2013;339:166-172.
27. Sirisinha S. Insight into the mechanisms regulating immune homeostasis in health and disease. Asian Pac J Allergy Immunol 2011;29:1-14.
28. Ermakov AV, Konkova MS, Kostyuk SV, Izevskaya VL, Baranova A, Veiko NN. Oxidized extracellular DNA as a stress signal in human cells. Oxid Med Cell Longev 2013;2013:649747.
29. Nakahira K, Kyung SY, Rogers AJ et al. Circulating mitochondrial DNA in patients in the ICU as a marker of mortality: derivation and validation. PLoS Med 2013;10:e1001577; discussion e.
30. Kung CT, Hsiao SY, Tsai TC et al. Plasma nuclear and mitochondrial DNA levels as predictors of outcome in severe sepsis patients in the emergency room. J Transl Med 2012;10:130.
31. Puskarich MA, Shapiro NI, Trzeciak S, Kline JA, Jones AE. Plasma levels of mitochondrial DNA in patients presenting to the emergency department with sepsis. Shock 2012;38:337-340.
32. Zitvogel L, Kepp O, Kroemer G. Decoding cell death signals in inflammation and immunity. Cell 2010;140:798-804.
33. Spisek R, Charalambous A, Mazumder A, Vesole DH, Jagannath S, Dhodapkar MV. Bortezomib enhances dendritic cell (DC)-mediated induction of immunity to human myeloma via exposure of cell surface heat shock protein 90 on dying tumor cells: therapeutic implications. Blood 2007;109:4839-4845.
34. Chen GY, Tang J, Zheng P, Liu Y. CD24 and Siglec-10 selectively repress tissue damage-induced immune responses. Science 2009;323:1722-1725.
35. Matza LS, Rajagopalan KS, Thompson CL, De Lissovoy G. Misdiagnosed patients with bipolar disorder: comorbidities, treatment patterns, and direct treatment costs. J Clin Psychiatry 2005;66:1432-1440.
36. Fischer M, Ehlers M. Toll-like receptors in autoimmunity. Ann N Y Acad Sci 2008;1143:21-34.
37. Do Prado CH, Rizzo LB, Wieck A et al. Reduced regulatory T cells are associated with higher levels of Th1/TH17 cytokines and activated MAPK in type 1 bipolar disorder. Psychoneuroendocrinology 2013;38:667-676.