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Volumn 890, Issue , 2016, Pages 75-110

The microenvironment of lung cancer and therapeutic implications

Author keywords

Angiogenesis; Bone marrow; Endothelial cells; Hypoxia; Immune cells; Immunotherapy; Infl ammation; Lung cancer; Microenvironment; Radiation; Resistance; Therapy

Indexed keywords

AFLIBERCEPT; ATEZOLIZUMAB; BEVACIZUMAB; BONE MORPHOGENETIC PROTEIN 4; BONE MORPHOGENETIC PROTEIN RECEPTOR 1A; CD11B ANTIGEN; CD14 ANTIGEN; CD15 ANTIGEN; CD33 ANTIGEN; CRIZOTINIB; DURVALUMAB; ENDOSTATIN; ERLOTINIB; GEFITINIB; GLYPICAN 3; HYPOXIA INDUCIBLE FACTOR 1ALPHA; IMMUNOSUPPRESSIVE AGENT; INTERCELLULAR ADHESION MOLECULE 1; IPILIMUMAB; L SELECTIN; LAMININ; MATRIX METALLOPROTEINASE 14; NIVOLUMAB; OSTEONECTIN; PADGEM PROTEIN; PAZOPANIB; PEMBROLIZUMAB; PROTEIN TYROSINE KINASE INHIBITOR; TICILIMUMAB; UNINDEXED DRUG; ANTINEOPLASTIC AGENT; MONOCLONAL ANTIBODY;

EID: 84951873945     PISSN: 00652598     EISSN: 22148019     Source Type: Book Series    
DOI: 10.1007/978-3-319-24932-2_5     Document Type: Chapter
Times cited : (117)

References (258)
  • 1
    • 68649089967 scopus 로고    scopus 로고
    • The role of bone-marrow-derived cells in tumor growth, metastasis initiation and progression
    • Gao D, Mittal V (2009) The role of bone-marrow-derived cells in tumor growth, metastasis initiation and progression. Trends Mol Med 15: 333-343.
    • (2009) Trends Mol Med , vol.15 , pp. 333-343
    • Gao, D.1    Mittal, V.2
  • 2
    • 84858590826 scopus 로고    scopus 로고
    • Accessories to the crime: Functions of cells recruited to the tumor microenvironment
    • Hanahan D, Coussens LM (2012) Accessories to the crime: functions of cells recruited to the tumor microenvironment. Cancer Cell 21: 309-322.
    • (2012) Cancer Cell , vol.21 , pp. 309-322
    • Hanahan, D.1    Coussens, L.M.2
  • 3
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: The next generation
    • Hanahan D, Weinberg RA (2011) Hallmarks of cancer: the next generation. Cell 144: 646-674.
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 4
    • 63049104211 scopus 로고    scopus 로고
    • Microenvironmental regulation of metastasis
    • Joyce JA, Pollard JW (2009) Microenvironmental regulation of metastasis. Nat Rev Cancer 9: 239-252.
    • (2009) Nat Rev Cancer , vol.9 , pp. 239-252
    • Joyce, J.A.1    Pollard, J.W.2
  • 5
    • 33846531356 scopus 로고    scopus 로고
    • The tumour microenvironment as a target for chemoprevention
    • Albini A, Sporn MB (2007) The tumour microenvironment as a target for chemoprevention. Nat Rev Cancer 7: 139-147.
    • (2007) Nat Rev Cancer , vol.7 , pp. 139-147
    • Albini, A.1    Sporn, M.B.2
  • 7
    • 79953244361 scopus 로고    scopus 로고
    • Antiangiogenic therapy: Impact on invasion, disease progression, and metastasis
    • Ebos JM, Kerbel RS (2011) Antiangiogenic therapy: impact on invasion, disease progression, and metastasis. Nat Rev Clin Oncol 8: 210-221.
    • (2011) Nat Rev Clin Oncol , vol.8 , pp. 210-221
    • Ebos, J.M.1    Kerbel, R.S.2
  • 8
    • 84867115486 scopus 로고    scopus 로고
    • Microenvironmental regulation of epithelial-mesenchymal transitions in cancer
    • Gao D, Vahdat LT, Wong S, Chang JC, Mittal V (2012) Microenvironmental regulation of epithelial-mesenchymal transitions in cancer. Cancer Res 72: 4883-4889.
    • (2012) Cancer Res , vol.72 , pp. 4883-4889
    • Gao, D.1    Vahdat, L.T.2    Wong, S.3    Chang, J.C.4    Mittal, V.5
  • 9
    • 67449098637 scopus 로고    scopus 로고
    • Chronic inflammation, chronic obstructive pulmonary disease, and lung cancer
    • Lee G, Walser TC, Dubinett SM (2009) Chronic inflammation, chronic obstructive pulmonary disease, and lung cancer. Curr Opin Pulm Med 15: 303-307.
    • (2009) Curr Opin Pulm Med , vol.15 , pp. 303-307
    • Lee, G.1    Walser, T.C.2    Dubinett, S.M.3
  • 10
    • 64749083599 scopus 로고    scopus 로고
    • Lung cancer and chronic obstructive pulmonary disease: Needs and opportunities for integrated research
    • Punturieri A, Szabo E, Croxton TL, Shapiro SD, Dubinett SM (2009) Lung cancer and chronic obstructive pulmonary disease: needs and opportunities for integrated research. J Natl Cancer Inst 101: 554-559.
    • (2009) J Natl Cancer Inst , vol.101 , pp. 554-559
    • Punturieri, A.1    Szabo, E.2    Croxton, T.L.3    Shapiro, S.D.4    Dubinett, S.M.5
  • 12
    • 77950944395 scopus 로고    scopus 로고
    • Macrophages, innate immunity and cancer: Balance, tolerance, and diversity
    • Mantovani A, Sica A (2010) Macrophages, innate immunity and cancer: balance, tolerance, and diversity. Curr Opin Immunol 22: 231-237.
    • (2010) Curr Opin Immunol , vol.22 , pp. 231-237
    • Mantovani, A.1    Sica, A.2
  • 13
  • 15
    • 0037180757 scopus 로고    scopus 로고
    • Inflammation and cancer
    • Coussens LM, Werb Z (2002) Inflammation and cancer. Nature 420: 860-867.
    • (2002) Nature , vol.420 , pp. 860-867
    • Coussens, L.M.1    Werb, Z.2
  • 16
    • 33845510147 scopus 로고    scopus 로고
    • Tumour-host interactions: Implications for developing anticancer therapies
    • Gadea BB, Joyce JA (2006) Tumour-host interactions: implications for developing anticancer therapies. Expert Rev Mol Med 8: 1-32.
    • (2006) Expert Rev Mol Med , vol.8 , pp. 1-32
    • Gadea, B.B.1    Joyce, J.A.2
  • 17
    • 20444412646 scopus 로고    scopus 로고
    • Therapeutic targeting of the tumor microenvironment
    • Joyce JA (2005) Therapeutic targeting of the tumor microenvironment. Cancer Cell 7: 513-520.
    • (2005) Cancer Cell , vol.7 , pp. 513-520
    • Joyce, J.A.1
  • 18
    • 0037967272 scopus 로고    scopus 로고
    • Angiogenesis: Tumorigenesis and the angiogenic switch
    • Bergers G, Benjamin LE (2003) Angiogenesis: tumorigenesis and the angiogenic switch. Nat Rev Cancer 3: 401-410.
    • (2003) Nat Rev Cancer , vol.3 , pp. 401-410
    • Bergers, G.1    Benjamin, L.E.2
  • 19
    • 0030576517 scopus 로고    scopus 로고
    • Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis
    • Hanahan D, Folkman J (1996) Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis. Cell 86: 353-364.
    • (1996) Cell , vol.86 , pp. 353-364
    • Hanahan, D.1    Folkman, J.2
  • 21
    • 0035496616 scopus 로고    scopus 로고
    • Colorectal cancer prevention and treatment by inhibition of cyclooxygenase-2
    • Gupta RA, Dubois RN (2001) Colorectal cancer prevention and treatment by inhibition of cyclooxygenase-2. Nat Rev Cancer 1: 11-21.
    • (2001) Nat Rev Cancer , vol.1 , pp. 11-21
    • Gupta, R.A.1    Dubois, R.N.2
  • 22
    • 78650825618 scopus 로고    scopus 로고
    • Effect of daily aspirin on long-term risk of death due to cancer: Analysis of individual patient data from randomised trials
    • Rothwell PM, Fowkes FG, Belch JF, Ogawa H, Warlow CP, Meade TW (2011) Effect of daily aspirin on long-term risk of death due to cancer: analysis of individual patient data from randomised trials. Lancet 377: 31-41.
    • (2011) Lancet , vol.377 , pp. 31-41
    • Rothwell, P.M.1    Fowkes, F.G.2    Belch, J.F.3    Ogawa, H.4    Warlow, C.P.5    Meade, T.W.6
  • 23
    • 84863399038 scopus 로고    scopus 로고
    • Effect of daily aspirin on risk of cancer metastasis: A study of incident cancers during randomised controlled trials
    • Rothwell PM, Wilson M, Price JF, Belch JF, Meade TW, Mehta Z (2012) Effect of daily aspirin on risk of cancer metastasis: a study of incident cancers during randomised controlled trials. Lancet 379: 1591-1601.
    • (2012) Lancet , vol.379 , pp. 1591-1601
    • Rothwell, P.M.1    Wilson, M.2    Price, J.F.3    Belch, J.F.4    Meade, T.W.5    Mehta, Z.6
  • 24
    • 47949090079 scopus 로고    scopus 로고
    • The role of myeloid cells in the promotion of tumour angiogenesis
    • Murdoch C, Muthana M, Coffelt SB, Lewis CE (2008) The role of myeloid cells in the promotion of tumour angiogenesis. Nat Rev Cancer 8: 618-631.
    • (2008) Nat Rev Cancer , vol.8 , pp. 618-631
    • Murdoch, C.1    Muthana, M.2    Coffelt, S.B.3    Lewis, C.E.4
  • 26
    • 77950931419 scopus 로고    scopus 로고
    • Matrix metalloproteinases: Regulators of the tumor microenvironment
    • Kessenbrock K, Plaks V, Werb Z (2010) Matrix metalloproteinases: regulators of the tumor microenvironment. Cell 141: 52-67.
    • (2010) Cell , vol.141 , pp. 52-67
    • Kessenbrock, K.1    Plaks, V.2    Werb, Z.3
  • 27
    • 31544441610 scopus 로고    scopus 로고
    • Distinct role of macrophages in different tumor microenvironments
    • Lewis CE, Pollard JW (2006) Distinct role of macrophages in different tumor microenvironments. Cancer Res 66: 605-612.
    • (2006) Cancer Res , vol.66 , pp. 605-612
    • Lewis, C.E.1    Pollard, J.W.2
  • 28
    • 68749109536 scopus 로고    scopus 로고
    • A distinct macrophage population mediates metastatic breast cancer cell extravasation, establishment and growth
    • Qian B, Deng Y, Im JH, Muschel RJ, Zou Y, Li J, Lang RA, Pollard JW (2009) A distinct macrophage population mediates metastatic breast cancer cell extravasation, establishment and growth. PLoS One 4, e6562.
    • (2009) PLoS One , vol.4
    • Qian, B.1    Deng, Y.2    Im, J.H.3    Muschel, R.J.4    Zou, Y.5    Li, J.6    Lang, R.A.7    Pollard, J.W.8
  • 29
    • 31044433663 scopus 로고    scopus 로고
    • Macrophages: Obligate partners for tumor cell migration, invasion, and metastasis
    • Condeelis J, Pollard JW (2006) Macrophages: obligate partners for tumor cell migration, invasion, and metastasis. Cell 124: 263-266.
    • (2006) Cell , vol.124 , pp. 263-266
    • Condeelis, J.1    Pollard, J.W.2
  • 30
    • 84865614917 scopus 로고    scopus 로고
    • Microglial stimulation of glioblastoma invasion involves epidermal growth factor receptor (EGFR) and colony stimulating factor 1 receptor (CSF-1R) signaling
    • Coniglio SJ, Eugenin E, Dobrenis K, Stanley ER, West BL, Symons MH, Segall JE (2012) Microglial stimulation of glioblastoma invasion involves epidermal growth factor receptor (EGFR) and colony stimulating factor 1 receptor (CSF-1R) signaling. Mol Med 18: 519-527.
    • (2012) Mol Med , vol.18 , pp. 519-527
    • Coniglio, S.J.1    Eugenin, E.2    Dobrenis, K.3    Stanley, E.R.4    West, B.L.5    Symons, M.H.6    Segall, J.E.7
  • 31
    • 20444436815 scopus 로고    scopus 로고
    • Macrophages promote the invasion of breast carcinoma cells via a colony-stimulating factor-1/epidermal growth factor paracrine loop
    • Goswami S, Sahai E, Wyckoff JB, Cammer M, Cox D, Pixley FJ, Stanley ER, Segall JE, Condeelis JS (2005) Macrophages promote the invasion of breast carcinoma cells via a colony-stimulating factor-1/epidermal growth factor paracrine loop. Cancer Res 65: 5278-5283.
    • (2005) Cancer Res , vol.65 , pp. 5278-5283
    • Goswami, S.1    Sahai, E.2    Wyckoff, J.B.3    Cammer, M.4    Cox, D.5    Pixley, F.J.6    Stanley, E.R.7    Segall, J.E.8    Condeelis, J.S.9
  • 36
    • 17644394616 scopus 로고    scopus 로고
    • Smoldering and polarized inflammation in the initiation and promotion of malignant disease
    • Balkwill F, Charles KA, Mantovani A (2005) Smoldering and polarized inflammation in the initiation and promotion of malignant disease. Cancer Cell 7: 211-217.
    • (2005) Cancer Cell , vol.7 , pp. 211-217
    • Balkwill, F.1    Charles, K.A.2    Mantovani, A.3
  • 37
    • 77950346282 scopus 로고    scopus 로고
    • Immunity, inflammation, and cancer
    • Grivennikov SI, Greten FR, Karin M (2010) Immunity, inflammation, and cancer. Cell 140: 883-899.
    • (2010) Cell , vol.140 , pp. 883-899
    • Grivennikov, S.I.1    Greten, F.R.2    Karin, M.3
  • 38
    • 80052014052 scopus 로고    scopus 로고
    • Inflammation meets cancer, with NF-κB as the matchmaker
    • Ben-Neriah Y, Karin M (2011) Inflammation meets cancer, with NF-κB as the matchmaker. Nat Immunol 12: 715-723.
    • (2011) Nat Immunol , vol.12 , pp. 715-723
    • Ben-Neriah, Y.1    Karin, M.2
  • 39
    • 77949379050 scopus 로고    scopus 로고
    • B-cell-derived lymphotoxin promotes castration-resistant prostate cancer
    • Ammirante M, Luo JL, Grivennikov S, Nedospasov S, Karin M (2010) B-cell-derived lymphotoxin promotes castration-resistant prostate cancer. Nature 464: 302-305.
    • (2010) Nature , vol.464 , pp. 302-305
    • Ammirante, M.1    Luo, J.L.2    Grivennikov, S.3    Nedospasov, S.4    Karin, M.5
  • 40
    • 3543102542 scopus 로고    scopus 로고
    • Inflammation and necrosis promote tumour growth
    • Vakkila J, Lotze MT (2004) Inflammation and necrosis promote tumour growth. Nat Rev Immunol 4: 641-648.
    • (2004) Nat Rev Immunol , vol.4 , pp. 641-648
    • Vakkila, J.1    Lotze, M.T.2
  • 42
    • 84858766182 scopus 로고    scopus 로고
    • The blockade of immune checkpoints in cancer immunotherapy
    • Pardoll DM (2012) The blockade of immune checkpoints in cancer immunotherapy. Nat Rev Cancer 12: 252-264.
    • (2012) Nat Rev Cancer , vol.12 , pp. 252-264
    • Pardoll, D.M.1
  • 44
    • 61349100687 scopus 로고    scopus 로고
    • Myeloid-derived suppressor cells as regulators of the immune system
    • Gabrilovich DI, Nagaraj S (2009) Myeloid-derived suppressor cells as regulators of the immune system. Nat Rev Immunol 9: 162-174.
    • (2009) Nat Rev Immunol , vol.9 , pp. 162-174
    • Gabrilovich, D.I.1    Nagaraj, S.2
  • 45
    • 79955723632 scopus 로고    scopus 로고
    • Myeloid derived suppressor cells in human diseases
    • Greten TF, Manns MP, Korangy F (2011) Myeloid derived suppressor cells in human diseases. Int Immunopharmacol 11: 802-807.
    • (2011) Int Immunopharmacol , vol.11 , pp. 802-807
    • Greten, T.F.1    Manns, M.P.2    Korangy, F.3
  • 46
    • 31344474166 scopus 로고    scopus 로고
    • Myeloid suppressor cells in cancer: Recruitment, phenotype, properties, and mechanisms of immune suppression
    • Serafini P, Borrello I, Bronte V (2006) Myeloid suppressor cells in cancer: recruitment, phenotype, properties, and mechanisms of immune suppression. Semin Cancer Biol 16: 53-65.
    • (2006) Semin Cancer Biol , vol.16 , pp. 53-65
    • Serafini, P.1    Borrello, I.2    Bronte, V.3
  • 47
    • 80054102628 scopus 로고    scopus 로고
    • Elevated myeloidderived suppressor cells in pancreatic, esophageal and gastric cancer are an independent prognostic factor and are associated with significant elevation of the Th2 cytokine interleukin-13
    • Gabitass RF, Annels NE, Stocken DD, Pandha HA, Middleton GW (2011) Elevated myeloidderived suppressor cells in pancreatic, esophageal and gastric cancer are an independent prognostic factor and are associated with significant elevation of the Th2 cytokine interleukin-13. Cancer Immunol Immunother 60: 1419-1430.
    • (2011) Cancer Immunol Immunother , vol.60 , pp. 1419-1430
    • Gabitass, R.F.1    Annels, N.E.2    Stocken, D.D.3    Pandha, H.A.4    Middleton, G.W.5
  • 50
    • 84884556145 scopus 로고    scopus 로고
    • History of myeloid-derived suppressor cells
    • Talmadge JE, Gabrilovich DI (2013) History of myeloid-derived suppressor cells. Nat Rev Cancer 13: 739-752.
    • (2013) Nat Rev Cancer , vol.13 , pp. 739-752
    • Talmadge, J.E.1    Gabrilovich, D.I.2
  • 51
    • 65249138393 scopus 로고    scopus 로고
    • Myeloid-derived suppressor cells: Linking inflammation and cancer
    • Ostrand-Rosenberg S, Sinha P (2009) Myeloid-derived suppressor cells: linking inflammation and cancer. J Immunol 182: 4499-4506.
    • (2009) J Immunol , vol.182 , pp. 4499-4506
    • Ostrand-Rosenberg, S.1    Sinha, P.2
  • 52
    • 84899560334 scopus 로고    scopus 로고
    • Signaling pathways involved in MDSC regulation
    • Trikha P, Carson WE (2014) Signaling pathways involved in MDSC regulation. Biochim Biophys Acta 1846: 55-65.
    • (2014) Biochim Biophys Acta , vol.1846 , pp. 55-65
    • Trikha, P.1    Carson, W.E.2
  • 56
    • 0042591427 scopus 로고    scopus 로고
    • Alltrans-retinoic acid eliminates immature myeloid cells from tumor-bearing mice and improves the effect of vaccination
    • Kusmartsev S, Cheng F, Yu B, Nefedova Y, Sotomayor E, Lush R, Gabrilovich D (2003) Alltrans-retinoic acid eliminates immature myeloid cells from tumor-bearing mice and improves the effect of vaccination. Cancer Res 63: 4441-4449.
    • (2003) Cancer Res , vol.63 , pp. 4441-4449
    • Kusmartsev, S.1    Cheng, F.2    Yu, B.3    Nefedova, Y.4    Sotomayor, E.5    Lush, R.6    Gabrilovich, D.7
  • 67
    • 18244371651 scopus 로고    scopus 로고
    • Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain
    • Pao W, Miller VA, Politi KA, Riely GJ, Somwar R, Zakowski MF, Kris MG, Varmus H (2005) Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain. PLoS Med 2, e73.
    • (2005) PLoS Med , vol.2
    • Pao, W.1    Miller, V.A.2    Politi, K.A.3    Riely, G.J.4    Somwar, R.5    Zakowski, M.F.6    Kris, M.G.7    Varmus, H.8
  • 72
    • 84863802475 scopus 로고    scopus 로고
    • Prognostic impact of cancerassociated stromal cells in stage I lung adenocarcinoma patients
    • Ito M, Ishii G, Nagai K, Maeda R, Nakano Y, Ochiai A (2012) Prognostic impact of cancerassociated stromal cells in stage I lung adenocarcinoma patients. Chest 142: 151-8.
    • (2012) Chest , vol.142 , pp. 151-158
    • Ito, M.1    Ishii, G.2    Nagai, K.3    Maeda, R.4    Nakano, Y.5    Ochiai, A.6
  • 73
    • 0037844993 scopus 로고    scopus 로고
    • cDNA microarray analysis of gene expression in pathologic stage IA nonsmall cell lung carcinomas
    • Nakamura H, Saji H, Ogata A, Hosaka M, Hagiwara M, Saijo T, Kawasaki N, Kato H (2003) cDNA microarray analysis of gene expression in pathologic stage IA nonsmall cell lung carcinomas. Cancer 97: 2798-2805.
    • (2003) Cancer , vol.97 , pp. 2798-2805
    • Nakamura, H.1    Saji, H.2    Ogata, A.3    Hosaka, M.4    Hagiwara, M.5    Saijo, T.6    Kawasaki, N.7    Kato, H.8
  • 74
    • 0037226593 scopus 로고    scopus 로고
    • A molecular signature of metastasis in primary solid tumors
    • Ramaswamy S, Ross KN, Lander ES, Golub TR (2003) A molecular signature of metastasis in primary solid tumors. Nat Genet 33: 49-54.
    • (2003) Nat Genet , vol.33 , pp. 49-54
    • Ramaswamy, S.1    Ross, K.N.2    Lander, E.S.3    Golub, T.R.4
  • 76
    • 54849440346 scopus 로고    scopus 로고
    • Increased circulating myeloid-derived suppressor cells correlate with clinical cancer stage, metastatic tumor burden, and doxorubicin-cyclophosphamide chemotherapy
    • Diaz-Montero CM, Salem ML, Nishimura MI, Garrett-Mayer E, Cole DJ, Montero AJ (2009) Increased circulating myeloid-derived suppressor cells correlate with clinical cancer stage, metastatic tumor burden, and doxorubicin-cyclophosphamide chemotherapy. Cancer Immunol Immunother 58: 49-59.
    • (2009) Cancer Immunol Immunother , vol.58 , pp. 49-59
    • Diaz-Montero, C.M.1    Salem, M.L.2    Nishimura, M.I.3    Garrett-Mayer, E.4    Cole, D.J.5    Montero, A.J.6
  • 77
    • 84869228608 scopus 로고    scopus 로고
    • CD14(+)S100A9(+) myeloid-derived suppressor cells portend decreased survival in patients with advanced lung cancer
    • Sharma S, Dubinett S, Salgia R (2012) CD14(+)S100A9(+) myeloid-derived suppressor cells portend decreased survival in patients with advanced lung cancer. Am J Respir Crit Care Med 186: 940-941.
    • (2012) Am J Respir Crit Care Med , vol.186 , pp. 940-941
    • Sharma, S.1    Dubinett, S.2    Salgia, R.3
  • 79
    • 0346751951 scopus 로고    scopus 로고
    • Pleiotropic effects of CXC chemokines in gastric carcinoma: Differences in CXCL8 and CXCL1 expression between diffuse and intestinal types of gastric carcinoma
    • Eck M, Schmausser B, Scheller K, Brändlein S, Müller-Hermelink HK (2003) Pleiotropic effects of CXC chemokines in gastric carcinoma: differences in CXCL8 and CXCL1 expression between diffuse and intestinal types of gastric carcinoma. Clin Exp Immunol 134: 508-515.
    • (2003) Clin Exp Immunol , vol.134 , pp. 508-515
    • Eck, M.1    Schmausser, B.2    Scheller, K.3    Brändlein, S.4    Müller-Hermelink, H.K.5
  • 81
    • 69549112977 scopus 로고    scopus 로고
    • The prognostic value of intraepithelial and stromal innate immune system cells in non-small cell lung carcinoma
    • Al-Shibli K, Al-Saad S, Donnem T, Persson M, Bremnes RM, Busund LT (2009) The prognostic value of intraepithelial and stromal innate immune system cells in non-small cell lung carcinoma. Histopathology 55: 301-312.
    • (2009) Histopathology , vol.55 , pp. 301-312
    • Al-Shibli, K.1    Al-Saad, S.2    Donnem, T.3    Persson, M.4    Bremnes, R.M.5    Busund, L.T.6
  • 83
    • 84890906410 scopus 로고    scopus 로고
    • The prognostic impact of tumorassociated macrophages and intra-tumoral apoptosis in non-small cell lung cancer
    • Becker M, Müller CB, De Bastiani MA, Klamt F (2014) The prognostic impact of tumorassociated macrophages and intra-tumoral apoptosis in non-small cell lung cancer. Histol Histopathol 29: 21-31.
    • (2014) Histol Histopathol , vol.29 , pp. 21-31
    • Becker, M.1    Müller, C.B.2    De Bastiani, M.A.3    Klamt, F.4
  • 84
    • 77952416002 scopus 로고    scopus 로고
    • The number and microlocalization of tumor-associated immune cells are associated with patient's survival time in non-small cell lung cancer
    • Dai F, Liu L, Che G, Yu N, Pu Q, Zhang S, Ma J, Ma L, You Z (2010) The number and microlocalization of tumor-associated immune cells are associated with patient's survival time in non-small cell lung cancer. BMC Cancer 10: 220.
    • (2010) BMC Cancer , vol.10 , pp. 220
    • Dai, F.1    Liu, L.2    Che, G.3    Yu, N.4    Pu, Q.5    Zhang, S.6    Ma, J.7    Ma, L.8    You, Z.9
  • 85
    • 0034659880 scopus 로고    scopus 로고
    • Mast cell density is associated with angiogenesis and poor prognosis in pulmonary adenocarcinoma
    • Takanami I, Takeuchi K, Naruke M (2000) Mast cell density is associated with angiogenesis and poor prognosis in pulmonary adenocarcinoma. Cancer 88: 2686-2692.
    • (2000) Cancer , vol.88 , pp. 2686-2692
    • Takanami, I.1    Takeuchi, K.2    Naruke, M.3
  • 86
    • 52649163840 scopus 로고    scopus 로고
    • Prognostic effect of epithelial and stromal lymphocyte infiltration in non-small cell lung cancer
    • Al-Shibli KI, Donnem T, Al-Saad S, Persson M, Bremnes RM, Busund LT (2008) Prognostic effect of epithelial and stromal lymphocyte infiltration in non-small cell lung cancer. Clin Cancer Res 14: 5220-5227.
    • (2008) Clin Cancer Res , vol.14 , pp. 5220-5227
    • Al-Shibli, K.I.1    Donnem, T.2    Al-Saad, S.3    Persson, M.4    Bremnes, R.M.5    Busund, L.T.6
  • 87
    • 0347506020 scopus 로고    scopus 로고
    • CD4+ T cells in cancer stroma, not CD8+ T cells in cancer cell nests, are associated with favorable prognosis in human non-small cell lung cancers
    • Wakabayashi O, Yamazaki K, Oizumi S, Hommura F, Kinoshita I, Ogura S, Dosaka-Akita H, Nishimura M (2003) CD4+ T cells in cancer stroma, not CD8+ T cells in cancer cell nests, are associated with favorable prognosis in human non-small cell lung cancers. Cancer Sci 94: 1003-1009.
    • (2003) Cancer Sci , vol.94 , pp. 1003-1009
    • Wakabayashi, O.1    Yamazaki, K.2    Oizumi, S.3    Hommura, F.4    Kinoshita, I.5    Ogura, S.6    Dosaka-Akita, H.7    Nishimura, M.8
  • 88
    • 77951877847 scopus 로고    scopus 로고
    • Tumor-infiltrating Foxp3+ regulatory T cells are correlated with cyclooxygenase-2 expression and are associated with recurrence in resected non-small cell lung cancer
    • Shimizu K, Nakata M, Hirami Y, Yukawa T, Maeda A, Tanemoto K (2010) Tumor-infiltrating Foxp3+ regulatory T cells are correlated with cyclooxygenase-2 expression and are associated with recurrence in resected non-small cell lung cancer. J Thorac Oncol 5: 585-590.
    • (2010) J Thorac Oncol , vol.5 , pp. 585-590
    • Shimizu, K.1    Nakata, M.2    Hirami, Y.3    Yukawa, T.4    Maeda, A.5    Tanemoto, K.6
  • 90
    • 84876724283 scopus 로고    scopus 로고
    • The prognostic relevance of tumour-infiltrating plasma cells and immunoglobulin kappa C indicates an important role of the humoral immune response in non-small cell lung cancer
    • Lohr M, Edlund K, Botling J, Hammad S, Hellwig B, Othman A, Berglund A, Lambe M, Holmberg L, Ekman S et al (2013) The prognostic relevance of tumour-infiltrating plasma cells and immunoglobulin kappa C indicates an important role of the humoral immune response in non-small cell lung cancer. Cancer Lett 333: 222-228.
    • (2013) Cancer Lett , vol.333 , pp. 222-228
    • Lohr, M.1    Edlund, K.2    Botling, J.3    Hammad, S.4    Hellwig, B.5    Othman, A.6    Berglund, A.7    Lambe, M.8    Holmberg, L.9    Ekman, S.10
  • 92
    • 0037114708 scopus 로고    scopus 로고
    • Modified scar grade: A prognostic indicator in small peripheral lung adenocarcinoma
    • Maeshima AM, Niki T, Maeshima A, Yamada T, Kondo H, Matsuno Y (2002) Modified scar grade: a prognostic indicator in small peripheral lung adenocarcinoma. Cancer 95: 2546-2554.
    • (2002) Cancer , vol.95 , pp. 2546-2554
    • Maeshima, A.M.1    Niki, T.2    Maeshima, A.3    Yamada, T.4    Kondo, H.5    Matsuno, Y.6
  • 94
    • 84901020848 scopus 로고    scopus 로고
    • Cancer-associated fibroblasts as another polarized cell type of the tumor microenvironment
    • Augsten M (2014) Cancer-associated fibroblasts as another polarized cell type of the tumor microenvironment. Front Oncol 4: 62.
    • (2014) Front Oncol , vol.4 , pp. 62
    • Augsten, M.1
  • 95
    • 84881030156 scopus 로고    scopus 로고
    • 'Cancer associated fibroblasts'-more than meets the eye
    • Madar S, Goldstein I, Rotter V (2013) 'Cancer associated fibroblasts'-more than meets the eye. Trends Mol Med 19: 447-453.
    • (2013) Trends Mol Med , vol.19 , pp. 447-453
    • Madar, S.1    Goldstein, I.2    Rotter, V.3
  • 96
    • 84876721085 scopus 로고    scopus 로고
    • Carcinoma-associated fibroblasts: Non-neoplastic tumourpromoting mesenchymal cells
    • Polanska UM, Orimo A (2013) Carcinoma-associated fibroblasts: non-neoplastic tumourpromoting mesenchymal cells. J Cell Physiol 228: 1651-1657.
    • (2013) J Cell Physiol , vol.228 , pp. 1651-1657
    • Polanska, U.M.1    Orimo, A.2
  • 97
  • 100
    • 60949101225 scopus 로고    scopus 로고
    • Cancer-associated fibroblasts and tumor growth-bystanders turning into key players
    • Ostman A, Augsten M (2009) Cancer-associated fibroblasts and tumor growth-bystanders turning into key players. Curr Opin Genet Dev 19: 67-73.
    • (2009) Curr Opin Genet Dev , vol.19 , pp. 67-73
    • Ostman, A.1    Augsten, M.2
  • 101
    • 84864955960 scopus 로고    scopus 로고
    • Understanding the role of stromal fibroblasts in cancer progression
    • Tripathi M, Billet S, Bhowmick NA (2012) Understanding the role of stromal fibroblasts in cancer progression. Cell Adh Migr 6: 231-235.
    • (2012) Cell Adh Migr , vol.6 , pp. 231-235
    • Tripathi, M.1    Billet, S.2    Bhowmick, N.A.3
  • 102
    • 77951233373 scopus 로고    scopus 로고
    • Cancer associated fibroblasts (CAFs) in tumor microenvironment
    • Xing F, Saidou J, Watabe K (2010) Cancer associated fibroblasts (CAFs) in tumor microenvironment. Front Biosci 15: 166-179.
    • (2010) Front Biosci , vol.15 , pp. 166-179
    • Xing, F.1    Saidou, J.2    Watabe, K.3
  • 103
    • 84887024873 scopus 로고    scopus 로고
    • Interaction between non-small-cell lung cancer cells and fibroblasts via enhancement of TGF-β signaling by IL-6
    • Abulaiti A, Shintani Y, Funaki S, Nakagiri T, Inoue M, Sawabata N, Minami M, Okumura M (2013) Interaction between non-small-cell lung cancer cells and fibroblasts via enhancement of TGF-β signaling by IL-6. Lung Cancer 82: 204-213.
    • (2013) Lung Cancer , vol.82 , pp. 204-213
    • Abulaiti, A.1    Shintani, Y.2    Funaki, S.3    Nakagiri, T.4    Inoue, M.5    Sawabata, N.6    Minami, M.7    Okumura, M.8
  • 104
    • 84869219069 scopus 로고    scopus 로고
    • Cross-species functional analysis of cancer-associated fibroblasts identifies a critical role for CLCF1 and IL-6 in non-small cell lung cancer in vivo
    • Vicent S, Sayles LC, Vaka D, Khatri P, Gevaert O, Chen R, Zheng Y, Gillespie AK, Clarke N, Xu Y et al (2012) Cross-species functional analysis of cancer-associated fibroblasts identifies a critical role for CLCF1 and IL-6 in non-small cell lung cancer in vivo. Cancer Res 72: 5744-5756.
    • (2012) Cancer Res , vol.72 , pp. 5744-5756
    • Vicent, S.1    Sayles, L.C.2    Vaka, D.3    Khatri, P.4    Gevaert, O.5    Chen, R.6    Zheng, Y.7    Gillespie, A.K.8    Clarke, N.9    Xu, Y.10
  • 107
    • 70350721786 scopus 로고    scopus 로고
    • Crosstalk to stromal fibroblasts induces resistance of lung cancer to epidermal growth factor receptor tyrosine kinase inhibitors
    • Wang W, Li Q, Yamada T, Matsumoto K, Matsumoto I, Oda M, Watanabe G, Kayano Y, Nishioka Y, Sone S et al (2009) Crosstalk to stromal fibroblasts induces resistance of lung cancer to epidermal growth factor receptor tyrosine kinase inhibitors. Clin Cancer Res 15: 6630-6638.
    • (2009) Clin Cancer Res , vol.15 , pp. 6630-6638
    • Wang, W.1    Li, Q.2    Yamada, T.3    Matsumoto, K.4    Matsumoto, I.5    Oda, M.6    Watanabe, G.7    Kayano, Y.8    Nishioka, Y.9    Sone, S.10
  • 108
    • 81755185464 scopus 로고    scopus 로고
    • Hepatocyte growth factor expression in EGFR mutant lung cancer with intrinsic and acquired resistance to tyrosine kinase inhibitors in a Japanese cohort
    • Yano S, Yamada T, Takeuchi S, Tachibana K, Minami Y, Yatabe Y, Mitsudomi T, Tanaka H, Kimura T, Kudoh S et al (2011) Hepatocyte growth factor expression in EGFR mutant lung cancer with intrinsic and acquired resistance to tyrosine kinase inhibitors in a Japanese cohort. J Thorac Oncol 6: 2011-2017.
    • (2011) J Thorac Oncol , vol.6 , pp. 2011-2017
    • Yano, S.1    Yamada, T.2    Takeuchi, S.3    Tachibana, K.4    Minami, Y.5    Yatabe, Y.6    Mitsudomi, T.7    Tanaka, H.8    Kimura, T.9    Kudoh, S.10
  • 110
    • 84255199629 scopus 로고    scopus 로고
    • The evolution of endothelial regulatory paradigms in cancer biology and vascular repair
    • Franses JW, Edelman ER (2011) The evolution of endothelial regulatory paradigms in cancer biology and vascular repair. Cancer Res 71: 7339-7344.
    • (2011) Cancer Res , vol.71 , pp. 7339-7344
    • Franses, J.W.1    Edelman, E.R.2
  • 111
    • 34748914299 scopus 로고    scopus 로고
    • Evolving functions of endothelial cells in inflammation
    • Pober JS, Sessa WC (2007) Evolving functions of endothelial cells in inflammation. Nat Rev Immunol 7: 803-815.
    • (2007) Nat Rev Immunol , vol.7 , pp. 803-815
    • Pober, J.S.1    Sessa, W.C.2
  • 113
    • 39149102867 scopus 로고    scopus 로고
    • The significance and relationship between mast cells and tumour angiogenesis in non-small cell lung carcinoma
    • Dundar E, Oner U, Peker BC, Metintas M, Isiksoy S, Ak G (2008) The significance and relationship between mast cells and tumour angiogenesis in non-small cell lung carcinoma. J Int Med Res 36: 88-95.
    • (2008) J Int Med Res , vol.36 , pp. 88-95
    • Dundar, E.1    Oner, U.2    Peker, B.C.3    Metintas, M.4    Isiksoy, S.5    Ak, G.6
  • 114
    • 19844364244 scopus 로고    scopus 로고
    • Angiogenesis and lung cancer: Prognostic and therapeutic implications
    • Herbst RS, Onn A, Sandler A (2005) Angiogenesis and lung cancer: prognostic and therapeutic implications. J Clin Oncol 23: 3243-3256.
    • (2005) J Clin Oncol , vol.23 , pp. 3243-3256
    • Herbst, R.S.1    Onn, A.2    Sandler, A.3
  • 119
    • 0036359548 scopus 로고    scopus 로고
    • Hypoxia-a key regulatory factor in tumour growth
    • Harris AL (2002) Hypoxia-a key regulatory factor in tumour growth. Nat Rev Cancer 2: 38-47.
    • (2002) Nat Rev Cancer , vol.2 , pp. 38-47
    • Harris, A.L.1
  • 120
    • 0142166332 scopus 로고    scopus 로고
    • Targeting HIF-1 for cancer therapy
    • Semenza GL (2003) Targeting HIF-1 for cancer therapy. Nat Rev Cancer 3: 721-732.
    • (2003) Nat Rev Cancer , vol.3 , pp. 721-732
    • Semenza, G.L.1
  • 121
    • 49849084552 scopus 로고    scopus 로고
    • Requirement of hypoxia-inducible factor-1alpha down-regulation in mediating the antitumor activity of the anti-epidermal growth factor receptor monoclonal antibody cetuximab
    • Li X, Lu Y, Liang K, Pan T, Mendelsohn J, Fan Z (2008) Requirement of hypoxia-inducible factor-1alpha down-regulation in mediating the antitumor activity of the anti-epidermal growth factor receptor monoclonal antibody cetuximab. Mol Cancer Ther 7: 1207-1217.
    • (2008) Mol Cancer Ther , vol.7 , pp. 1207-1217
    • Li, X.1    Lu, Y.2    Liang, K.3    Pan, T.4    Mendelsohn, J.5    Fan, Z.6
  • 124
    • 84875466646 scopus 로고    scopus 로고
    • Mechanistic links between COPD and lung cancer
    • Houghton AM (2013) Mechanistic links between COPD and lung cancer. Nat Rev Cancer 13: 233-245.
    • (2013) Nat Rev Cancer , vol.13 , pp. 233-245
    • Houghton, A.M.1
  • 126
    • 68849111316 scopus 로고    scopus 로고
    • Current concepts on the role of inflammation in COPD and lung cancer
    • Yao H, Rahman I (2009) Current concepts on the role of inflammation in COPD and lung cancer. Curr Opin Pharmacol 9: 375-383.
    • (2009) Curr Opin Pharmacol , vol.9 , pp. 375-383
    • Yao, H.1    Rahman, I.2
  • 129
    • 0034885944 scopus 로고    scopus 로고
    • Cigarette smoking and the risk of pulmonary metastasis from breast cancer
    • Murin S, Inciardi J (2001) Cigarette smoking and the risk of pulmonary metastasis from breast cancer. Chest 119: 1635-1640.
    • (2001) Chest , vol.119 , pp. 1635-1640
    • Murin, S.1    Inciardi, J.2
  • 130
    • 0029030387 scopus 로고
    • Influence of smoking on the development of lung metastases from breast cancer
    • Scanlon EF, Suh O, Murthy SM, Mettlin C, Reid SE, Cummings KM (1995) Influence of smoking on the development of lung metastases from breast cancer. Cancer 75: 2693-2699.
    • (1995) Cancer , vol.75 , pp. 2693-2699
    • Scanlon, E.F.1    Suh, O.2    Murthy, S.M.3    Mettlin, C.4    Reid, S.E.5    Cummings, K.M.6
  • 132
    • 12844286840 scopus 로고    scopus 로고
    • The effect of cigarette smoke exposure on pulmonary metastatic disease in a murine model of metastatic breast cancer
    • Murin S, Pinkerton KE, Hubbard NE, Erickson K (2004) The effect of cigarette smoke exposure on pulmonary metastatic disease in a murine model of metastatic breast cancer. Chest 125: 1467-1471.
    • (2004) Chest , vol.125 , pp. 1467-1471
    • Murin, S.1    Pinkerton, K.E.2    Hubbard, N.E.3    Erickson, K.4
  • 135
    • 84883475479 scopus 로고    scopus 로고
    • The ubiquitin-CXCR4 axis plays an important role in acute lung infection-enhanced lung tumor metastasis
    • Yan L, Cai Q, Xu Y (2013) The ubiquitin-CXCR4 axis plays an important role in acute lung infection-enhanced lung tumor metastasis. Clin Cancer Res 19: 4706-4716.
    • (2013) Clin Cancer Res , vol.19 , pp. 4706-4716
    • Yan, L.1    Cai, Q.2    Xu, Y.3
  • 136
    • 84901720015 scopus 로고    scopus 로고
    • Systemic inflammation promotes lung metastasis via E-selectin upregulation in mouse breast cancer model
    • Jiang M, Xu X, Bi Y, Xu J, Qin C, Han M (2014) Systemic inflammation promotes lung metastasis via E-selectin upregulation in mouse breast cancer model. Cancer Biol Ther 15: 789-796.
    • (2014) Cancer Biol Ther , vol.15 , pp. 789-796
    • Jiang, M.1    Xu, X.2    Bi, Y.3    Xu, J.4    Qin, C.5    Han, M.6
  • 138
    • 84859719825 scopus 로고    scopus 로고
    • RhoGDI2 suppresses lung metastasis in mice by reducing tumor versican expression and macrophage infiltration
    • Said N, Sanchez-Carbayo M, Smith SC, Theodorescu D (2012) RhoGDI2 suppresses lung metastasis in mice by reducing tumor versican expression and macrophage infiltration. J Clin Invest 122: 1503-1518.
    • (2012) J Clin Invest , vol.122 , pp. 1503-1518
    • Said, N.1    Sanchez-Carbayo, M.2    Smith, S.C.3    Theodorescu, D.4
  • 141
    • 82255161187 scopus 로고    scopus 로고
    • Cross-talk between tumor cells and the microenvironment at the metastatic niche
    • Carlini MJ, De Lorenzo MS, Puricelli L (2011) Cross-talk between tumor cells and the microenvironment at the metastatic niche. Curr Pharm Biotechnol 12: 1900-1908.
    • (2011) Curr Pharm Biotechnol , vol.12 , pp. 1900-1908
    • Carlini, M.J.1    De Lorenzo, M.S.2    Puricelli, L.3
  • 142
    • 57849100048 scopus 로고    scopus 로고
    • Hypoxia-induced lysyl oxidase is a critical mediator of bone marrow cell recruitment to form the premetastatic niche
    • Erler JT, Bennewith KL, Cox TR, Lang G, Bird D, Koong A, Le QT, Giaccia AJ (2009) Hypoxia-induced lysyl oxidase is a critical mediator of bone marrow cell recruitment to form the premetastatic niche. Cancer Cell 15: 35-44.
    • (2009) Cancer Cell , vol.15 , pp. 35-44
    • Erler, J.T.1    Bennewith, K.L.2    Cox, T.R.3    Lang, G.4    Bird, D.5    Koong, A.6    Le, Q.T.7    Giaccia, A.J.8
  • 143
    • 33751504690 scopus 로고    scopus 로고
    • Tumour-mediated upregulation of chemoattractants and recruitment of myeloid cells predetermines lung metastasis
    • Hiratsuka S, Watanabe A, Aburatani H, Maru Y (2006) Tumour-mediated upregulation of chemoattractants and recruitment of myeloid cells predetermines lung metastasis. Nat Cell Biol 8: 1369-1375.
    • (2006) Nat Cell Biol , vol.8 , pp. 1369-1375
    • Hiratsuka, S.1    Watanabe, A.2    Aburatani, H.3    Maru, Y.4
  • 144
    • 33846044750 scopus 로고    scopus 로고
    • Bone marrow cells in the 'pre-metastatic niche': Within bone and beyond
    • Kaplan RN, Psaila B, Lyden D (2006) Bone marrow cells in the 'pre-metastatic niche': within bone and beyond. Cancer Metastasis Rev 25: 521-529.
    • (2006) Cancer Metastasis Rev , vol.25 , pp. 521-529
    • Kaplan, R.N.1    Psaila, B.2    Lyden, D.3
  • 145
    • 63049121364 scopus 로고    scopus 로고
    • The metastatic niche: Adapting the foreign soil
    • Psaila B, Lyden D (2009) The metastatic niche: adapting the foreign soil. Nat Rev Cancer 9: 285-293.
    • (2009) Nat Rev Cancer , vol.9 , pp. 285-293
    • Psaila, B.1    Lyden, D.2
  • 147
    • 84890933630 scopus 로고    scopus 로고
    • Update on immune checkpoint inhibitors in lung cancer
    • Creelan BC (2014) Update on immune checkpoint inhibitors in lung cancer. Cancer Control 21: 80-89.
    • (2014) Cancer Control , vol.21 , pp. 80-89
    • Creelan, B.C.1
  • 149
    • 77954143558 scopus 로고    scopus 로고
    • Gammadelta T cell effector functions: A blend of innate programming and acquired plasticity
    • Bonneville M, O'Brien RL, Born WK (2010) Gammadelta T cell effector functions: a blend of innate programming and acquired plasticity. Nat Rev Immunol 10: 467-478.
    • (2010) Nat Rev Immunol , vol.10 , pp. 467-478
    • Bonneville, M.1    O'Brien, R.L.2    Born, W.K.3
  • 150
    • 70349127747 scopus 로고    scopus 로고
    • Adoptive immunotherapy of lung cancer with immobilized anti-TCRgammadelta antibody-expanded human gammadelta T-cells in peripheral blood
    • Kang N, Zhou J, Zhang T, Wang L, Lu F, Cui Y, Cui L, He W (2009) Adoptive immunotherapy of lung cancer with immobilized anti-TCRgammadelta antibody-expanded human gammadelta T-cells in peripheral blood. Cancer Biol Ther 8: 1540-1549.
    • (2009) Cancer Biol Ther , vol.8 , pp. 1540-1549
    • Kang, N.1    Zhou, J.2    Zhang, T.3    Wang, L.4    Lu, F.5    Cui, Y.6    Cui, L.7    He, W.8
  • 151
    • 77951296062 scopus 로고    scopus 로고
    • A phase I study of adoptive immunotherapy for recurrent non-small-cell lung cancer patients with autologous gammadelta T cells
    • Nakajima J, Murakawa T, Fukami T, Goto S, Kaneko T, Yoshida Y, Takamoto S, Kakimi K (2010) A phase I study of adoptive immunotherapy for recurrent non-small-cell lung cancer patients with autologous gammadelta T cells. Eur J Cardiothorac Surg 37: 1191-1197.
    • (2010) Eur J Cardiothorac Surg , vol.37 , pp. 1191-1197
    • Nakajima, J.1    Murakawa, T.2    Fukami, T.3    Goto, S.4    Kaneko, T.5    Yoshida, Y.6    Takamoto, S.7    Kakimi, K.8
  • 152
    • 77950532926 scopus 로고    scopus 로고
    • Complete remission of lung metastasis following adoptive immunotherapy using activated autologous gammadelta T-cells in a patient with renal cell carcinoma
    • Kobayashi H, Tanaka Y, Shimmura H, Minato N, Tanabe K (2010) Complete remission of lung metastasis following adoptive immunotherapy using activated autologous gammadelta T-cells in a patient with renal cell carcinoma. Anticancer Res 30: 575-579.
    • (2010) Anticancer Res , vol.30 , pp. 575-579
    • Kobayashi, H.1    Tanaka, Y.2    Shimmura, H.3    Minato, N.4    Tanabe, K.5
  • 154
    • 0032973003 scopus 로고    scopus 로고
    • Myeloid progenitor cells mediate immune suppression in patients with head and neck cancers
    • Young MR, Lathers DM (1999) Myeloid progenitor cells mediate immune suppression in patients with head and neck cancers. Int J Immunopharmacol 21: 241-252.
    • (1999) Int J Immunopharmacol , vol.21 , pp. 241-252
    • Young, M.R.1    Lathers, D.M.2
  • 155
    • 0031570886 scopus 로고    scopus 로고
    • Myeloid differentiation treatment to diminish the presence of immune-suppressive CD34+ cells within human head and neck squamous cell carcinomas
    • Young MR, Wright MA, Pandit R (1997) Myeloid differentiation treatment to diminish the presence of immune-suppressive CD34+ cells within human head and neck squamous cell carcinomas. J Immunol 159: 990-996.
    • (1997) J Immunol , vol.159 , pp. 990-996
    • Young, M.R.1    Wright, M.A.2    Pandit, R.3
  • 159
    • 84883447186 scopus 로고    scopus 로고
    • Increased CD14(+)HLA-DR (-/low) myeloid-derived suppressor cells correlate with extrathoracic metastasis and poor response to chemotherapy in non-small cell lung cancer patients
    • Huang A, Zhang B, Wang B, Zhang F, Fan KX, Guo YJ (2013) Increased CD14(+)HLA-DR (-/low) myeloid-derived suppressor cells correlate with extrathoracic metastasis and poor response to chemotherapy in non-small cell lung cancer patients. Cancer Immunol Immunother 62: 1439-1451.
    • (2013) Cancer Immunol Immunother , vol.62 , pp. 1439-1451
    • Huang, A.1    Zhang, B.2    Wang, B.3    Zhang, F.4    Fan, K.X.5    Guo, Y.J.6
  • 160
    • 0024708518 scopus 로고
    • The distribution of secondary growths in cancer of the breast. 1889
    • Paget S (1989) The distribution of secondary growths in cancer of the breast. 1889. Cancer Metastasis Rev 8: 98-101.
    • (1989) Cancer Metastasis Rev , vol.8 , pp. 98-101
    • Paget, S.1
  • 162
    • 84934439435 scopus 로고    scopus 로고
    • Hypoxia-mediated metastasis
    • Chang J, Erler J (2014) Hypoxia-mediated metastasis. Adv Exp Med Biol 772: 55-81.
    • (2014) Adv Exp Med Biol , vol.772 , pp. 55-81
    • Chang, J.1    Erler, J.2
  • 166
    • 84858199187 scopus 로고    scopus 로고
    • Myeloid progenitor cells in the premetastatic lung promote metastases by inducing mesenchymal to epithelial transition
    • Gao D, Joshi N, Choi H, Ryu S, Hahn M, Catena R, Sadik H, Argani P, Wagner P, Vahdat LT et al (2012) Myeloid progenitor cells in the premetastatic lung promote metastases by inducing mesenchymal to epithelial transition. Cancer Res 72: 1384-1394.
    • (2012) Cancer Res , vol.72 , pp. 1384-1394
    • Gao, D.1    Joshi, N.2    Choi, H.3    Ryu, S.4    Hahn, M.5    Catena, R.6    Sadik, H.7    Argani, P.8    Wagner, P.9    Vahdat, L.T.10
  • 167
    • 38149006909 scopus 로고    scopus 로고
    • Endothelial progenitor cells control the angiogenic switch in mouse lung metastasis
    • Gao D, Nolan DJ, Mellick AS, Bambino K, McDonnell K, Mittal V (2008) Endothelial progenitor cells control the angiogenic switch in mouse lung metastasis. Science 319: 195-198.
    • (2008) Science , vol.319 , pp. 195-198
    • Gao, D.1    Nolan, D.J.2    Mellick, A.S.3    Bambino, K.4    McDonnell, K.5    Mittal, V.6
  • 168
    • 84878112295 scopus 로고    scopus 로고
    • Bone marrow microenvironment in cancer patients: Immunological aspects and clinical implications
    • Stefanovic S, Schuetz F, Sohn C, Beckhove P, Domschke C (2013) Bone marrow microenvironment in cancer patients: immunological aspects and clinical implications. Cancer Metastasis Rev 32: 163-178.
    • (2013) Cancer Metastasis Rev , vol.32 , pp. 163-178
    • Stefanovic, S.1    Schuetz, F.2    Sohn, C.3    Beckhove, P.4    Domschke, C.5
  • 170
    • 84884368877 scopus 로고    scopus 로고
    • Influence of tumour micro-environment heterogeneity on therapeutic response
    • Junttila MR, de Sauvage FJ (2013) Influence of tumour micro-environment heterogeneity on therapeutic response. Nature 501: 346-354.
    • (2013) Nature , vol.501 , pp. 346-354
    • Junttila, M.R.1    de Sauvage, F.J.2
  • 171
    • 69249087671 scopus 로고    scopus 로고
    • Environment-mediated drug resistance: A major contributor to minimal residual disease
    • Meads MB, Gatenby RA, Dalton WS (2009) Environment-mediated drug resistance: a major contributor to minimal residual disease. Nat Rev Cancer 9: 665-674.
    • (2009) Nat Rev Cancer , vol.9 , pp. 665-674
    • Meads, M.B.1    Gatenby, R.A.2    Dalton, W.S.3
  • 173
    • 0035842893 scopus 로고    scopus 로고
    • BRCA1-induced large-scale chromatin unfolding and allele-specific effects of cancer-predisposing mutations
    • Ye Q, Hu Y, Zhong H, Nye A, Belmont A, Li R (2001) BRCA1-induced large-scale chromatin unfolding and allele-specific effects of cancer-predisposing mutations. J Cell Biol 155: 911-921.
    • (2001) J Cell Biol , vol.155 , pp. 911-921
    • Ye, Q.1    Hu, Y.2    Zhong, H.3    Nye, A.4    Belmont, A.5    Li, R.6
  • 174
    • 0032587877 scopus 로고    scopus 로고
    • Conditional mutation of Brca1 in mammary epithelial cells results in blunted ductal morphogenesis and tumour formation
    • Xu X, Wagner K, Larson D, Weaver Z, Li C, Ried T, Hennighausen L, Wynshaw-Boris A, Deng C (1999) Conditional mutation of Brca1 in mammary epithelial cells results in blunted ductal morphogenesis and tumour formation. Nat Genet 22: 37-43.
    • (1999) Nat Genet , vol.22 , pp. 37-43
    • Xu, X.1    Wagner, K.2    Larson, D.3    Weaver, Z.4    Li, C.5    Ried, T.6    Hennighausen, L.7    Wynshaw-Boris, A.8    Deng, C.9
  • 175
    • 0033605681 scopus 로고    scopus 로고
    • Positive regulation of the BRCA1 promoter
    • Thakur S, Croce C (1999) Positive regulation of the BRCA1 promoter. J Biol Chem 274: 8837-8843.
    • (1999) J Biol Chem , vol.274 , pp. 8837-8843
    • Thakur, S.1    Croce, C.2
  • 177
    • 0030761231 scopus 로고    scopus 로고
    • Complex regulation of the BRCA1 gene
    • Xu C-F, Chambers J, Solomon E (1997) Complex regulation of the BRCA1 gene. J Biol Chem 272: 20994-20997.
    • (1997) J Biol Chem , vol.272 , pp. 20994-20997
    • Xu, C.-F.1    Chambers, J.2    Solomon, E.3
  • 178
    • 0034910969 scopus 로고    scopus 로고
    • Expression of BRCA1, NBR1 and NBR2 genes in human breast cancer cells
    • Dimitrov S, Matouskova E, Forejt J (2001) Expression of BRCA1, NBR1 and NBR2 genes in human breast cancer cells. Folia Biol 47: 120-127.
    • (2001) Folia Biol , vol.47 , pp. 120-127
    • Dimitrov, S.1    Matouskova, E.2    Forejt, J.3
  • 179
  • 180
    • 0029997175 scopus 로고    scopus 로고
    • BRCA1 and BRCA2 mRNA levels are coordinately elevated in human breast cancer cells in response to estrogen
    • Spillman M, Bowcock A (1996) BRCA1 and BRCA2 mRNA levels are coordinately elevated in human breast cancer cells in response to estrogen. Oncogene 13: 1639-1645.
    • (1996) Oncogene , vol.13 , pp. 1639-1645
    • Spillman, M.1    Bowcock, A.2
  • 181
    • 0033615623 scopus 로고    scopus 로고
    • Transcription of BRCA1 is dependent on the formation of a specific protein-DNA complex on the minimal BRCA1 Bi-directional promoter
    • Suen T, Goss P (1999) Transcription of BRCA1 is dependent on the formation of a specific protein-DNA complex on the minimal BRCA1 Bi-directional promoter. J Biol Chem 274: 31297-31304.
    • (1999) J Biol Chem , vol.274 , pp. 31297-31304
    • Suen, T.1    Goss, P.2
  • 183
    • 0034611603 scopus 로고    scopus 로고
    • GA-binding protein alpha/beta is a critical regulator of the BRCA1 promoter
    • Atlas E, Stramwasser M, Whiskin K, Mueller C (2000) GA-binding protein alpha/beta is a critical regulator of the BRCA1 promoter. Oncogene 19: 1933-1940.
    • (2000) Oncogene , vol.19 , pp. 1933-1940
    • Atlas, E.1    Stramwasser, M.2    Whiskin, K.3    Mueller, C.4
  • 184
    • 0029115660 scopus 로고
    • The developmental pattern of Brca1 expression implies a role in differentiation of the breast and other tissues
    • Marquis S, Rajan J, Wynshaw-Boris A, Xu J, Yin G, Abel K, Weber B, Chodosh L (1995) The developmental pattern of Brca1 expression implies a role in differentiation of the breast and other tissues. Nat Genet 11: 17-26.
    • (1995) Nat Genet , vol.11 , pp. 17-26
    • Marquis, S.1    Rajan, J.2    Wynshaw-Boris, A.3    Xu, J.4    Yin, G.5    Abel, K.6    Weber, B.7    Chodosh, L.8
  • 186
    • 0032519554 scopus 로고    scopus 로고
    • Think globally, act locally: The making of a mouse mammary gland
    • Hennighausen L, Robinson G (1998) Think globally, act locally: the making of a mouse mammary gland. Genes Dev 12: 449-455.
    • (1998) Genes Dev , vol.12 , pp. 449-455
    • Hennighausen, L.1    Robinson, G.2
  • 188
    • 0031569873 scopus 로고    scopus 로고
    • Developmental expression of Brca2 colocalizes with Brca1 and is associated with proliferation and differentiation in multiple tissues
    • Rajan J, Marquis S, Gardner H, Chodosh L (1997) Developmental expression of Brca2 colocalizes with Brca1 and is associated with proliferation and differentiation in multiple tissues. Dev Biol 184: 385-401.
    • (1997) Dev Biol , vol.184 , pp. 385-401
    • Rajan, J.1    Marquis, S.2    Gardner, H.3    Chodosh, L.4
  • 189
    • 84883493454 scopus 로고    scopus 로고
    • Biologically augmenting radiation therapy by inhibiting TGFβ actions in carcinomas
    • Du S, Barcellos-Hoff MH (2013) Biologically augmenting radiation therapy by inhibiting TGFβ actions in carcinomas. Semin Radiat Oncol 23: 242-251.
    • (2013) Semin Radiat Oncol , vol.23 , pp. 242-251
    • Du, S.1    Barcellos-Hoff, M.H.2
  • 190
    • 84887015356 scopus 로고    scopus 로고
    • Ionizing-radiation induced DNA double-strand breaks: A direct and indirect lighting up
    • Vignard J, Mirey G, Salles B (2013) Ionizing-radiation induced DNA double-strand breaks: a direct and indirect lighting up. Radiother Oncol 108: 362-369.
    • (2013) Radiother Oncol , vol.108 , pp. 362-369
    • Vignard, J.1    Mirey, G.2    Salles, B.3
  • 192
    • 77949697909 scopus 로고    scopus 로고
    • Inhibition of vasculogenesis, but not angiogenesis, prevents the recurrence of glioblastoma after irradiation in mice
    • Kioi M, Vogel H, Schultz G, Hoffman RM, Harsh GR, Brown JM (2010) Inhibition of vasculogenesis, but not angiogenesis, prevents the recurrence of glioblastoma after irradiation in mice. J Clin Invest 120: 694-705.
    • (2010) J Clin Invest , vol.120 , pp. 694-705
    • Kioi, M.1    Vogel, H.2    Schultz, G.3    Hoffman, R.M.4    Harsh, G.R.5    Brown, J.M.6
  • 193
    • 28544438548 scopus 로고    scopus 로고
    • Radiation and the microenvironment-tumorigenesis and therapy
    • Barcellos-Hoff MH, Park C, Wright EG (2005) Radiation and the microenvironment-tumorigenesis and therapy. Nat Rev Cancer 5: 867-875.
    • (2005) Nat Rev Cancer , vol.5 , pp. 867-875
    • Barcellos-Hoff, M.H.1    Park, C.2    Wright, E.G.3
  • 194
    • 79953054421 scopus 로고    scopus 로고
    • Strategies to improve radiotherapy with targeted drugs
    • Begg AC, Stewart FA, Vens C (2011) Strategies to improve radiotherapy with targeted drugs. Nat Cancer Rev 11: 239-253.
    • (2011) Nat Cancer Rev , vol.11 , pp. 239-253
    • Begg, A.C.1    Stewart, F.A.2    Vens, C.3
  • 195
    • 0037312899 scopus 로고    scopus 로고
    • The not-so innocent bystander: Microenvironment as a target of cancer therapy
    • Erickson AC, Barcellos-Hoff MH (2003) The not-so innocent bystander: microenvironment as a target of cancer therapy. Expert Opin Ther Targets 7: 71-88.
    • (2003) Expert Opin Ther Targets , vol.7 , pp. 71-88
    • Erickson, A.C.1    Barcellos-Hoff, M.H.2
  • 196
    • 0035281783 scopus 로고    scopus 로고
    • Transforming growth factor-beta1 level correlates with angiogenesis, tumor progression, and prognosis in patients with nonsmall cell lung carcinoma
    • Hasegawa Y, Takanashi S, Kanehira Y, Tsushima T, Imai T, Okumura K (2001) Transforming growth factor-beta1 level correlates with angiogenesis, tumor progression, and prognosis in patients with nonsmall cell lung carcinoma. Cancer 91: 964-971.
    • (2001) Cancer , vol.91 , pp. 964-971
    • Hasegawa, Y.1    Takanashi, S.2    Kanehira, Y.3    Tsushima, T.4    Imai, T.5    Okumura, K.6
  • 198
    • 0032032322 scopus 로고    scopus 로고
    • Loss of nuclear BRCA1 expression in breast cancers is associated with a highly proliferative tumor phenotype
    • Jarvis E, Kirk J, Clarke C (1998) Loss of nuclear BRCA1 expression in breast cancers is associated with a highly proliferative tumor phenotype. Cancer Genet Cytogenet 101: 109-115.
    • (1998) Cancer Genet Cytogenet , vol.101 , pp. 109-115
    • Jarvis, E.1    Kirk, J.2    Clarke, C.3
  • 199
    • 84866985855 scopus 로고    scopus 로고
    • Targeting the TGF[beta] signalling pathway in disease
    • Akhurst RJ, Hata A (2012) Targeting the TGF[beta] signalling pathway in disease. Nat Rev Drug Discov 11: 790-811.
    • (2012) Nat Rev Drug Discov , vol.11 , pp. 790-811
    • Akhurst, R.J.1    Hata, A.2
  • 201
    • 79958082880 scopus 로고    scopus 로고
    • Trimodal glioblastoma treatment consisting of concurrent radiotherapy, temozolomide, and the novel TGF-β receptor I kinase inhibitor LY2109761
    • Zhang M, Herion TW, Timke C, Han N, Hauser K, Weber KJ, Peschke P, Wirkner U, Lahn M, Huber PE (2011) Trimodal glioblastoma treatment consisting of concurrent radiotherapy, temozolomide, and the novel TGF-β receptor I kinase inhibitor LY2109761. Neoplasia 13: 537-549.
    • (2011) Neoplasia , vol.13 , pp. 537-549
    • Zhang, M.1    Herion, T.W.2    Timke, C.3    Han, N.4    Hauser, K.5    Weber, K.J.6    Peschke, P.7    Wirkner, U.8    Lahn, M.9    Huber, P.E.10
  • 203
    • 67549086678 scopus 로고    scopus 로고
    • Transforming growth factor-beta in breast cancer: Too much, too late
    • Barcellos-Hoff MH, Akhurst RJ (2010) Transforming growth factor-beta in breast cancer: too much, too late. Breast Cancer Res Treat 11: 202-208.
    • (2010) Breast Cancer Res Treat , vol.11 , pp. 202-208
    • Barcellos-Hoff, M.H.1    Akhurst, R.J.2
  • 206
    • 0031874053 scopus 로고    scopus 로고
    • An important role for BRCA1 in breast cancer progression is indicated by its loss in a large proportion of non-familial breast cancers
    • Taylor J, Lymboura M, Pace P, A'hern R, Desai A, Shousha S, Coombes R, Ali S (1998) An important role for BRCA1 in breast cancer progression is indicated by its loss in a large proportion of non-familial breast cancers. Int J Cancer 79: 334-342.
    • (1998) Int J Cancer , vol.79 , pp. 334-342
    • Taylor, J.1    Lymboura, M.2    Pace, P.3    A'hern, R.4    Desai, A.5    Shousha, S.6    Coombes, R.7    Ali, S.8
  • 207
    • 19944401190 scopus 로고    scopus 로고
    • Promotion of mammary cancer development by tamoxifen in a mouse model of Brca1-mutation-related breast cancer
    • Jones LP, Li M, Halama ED, Ma Y, Lubet R, Grubbs CJ, Deng CX, Rosen EM, Furth PA (2005) Promotion of mammary cancer development by tamoxifen in a mouse model of Brca1-mutation-related breast cancer. Oncogene 24: 3554-3562.
    • (2005) Oncogene , vol.24 , pp. 3554-3562
    • Jones, L.P.1    Li, M.2    Halama, E.D.3    Ma, Y.4    Lubet, R.5    Grubbs, C.J.6    Deng, C.X.7    Rosen, E.M.8    Furth, P.A.9
  • 208
    • 84881112672 scopus 로고    scopus 로고
    • The evolution of the cancer niche during multistage carcinogenesis
    • Barcellos-Hoff MH, Lyden D, Wang TC (2013) The evolution of the cancer niche during multistage carcinogenesis. Nat Rev Cancer 13: 511-518.
    • (2013) Nat Rev Cancer , vol.13 , pp. 511-518
    • Barcellos-Hoff, M.H.1    Lyden, D.2    Wang, T.C.3
  • 209
    • 67649359533 scopus 로고    scopus 로고
    • Systemic effects of local radiotherapy
    • Formenti SC, Demaria S (2009) Systemic effects of local radiotherapy. Lancet Oncol 10: 718-726.
    • (2009) Lancet Oncol , vol.10 , pp. 718-726
    • Formenti, S.C.1    Demaria, S.2
  • 214
    • 84866734165 scopus 로고    scopus 로고
    • Developmental antiangiogenic agents for the treatment of nonsmall cell lung cancer (NSCLC)
    • Blumenschein GR (2012) Developmental antiangiogenic agents for the treatment of nonsmall cell lung cancer (NSCLC). Invest New Drugs 30: 1802-1811.
    • (2012) Invest New Drugs , vol.30 , pp. 1802-1811
    • Blumenschein, G.R.1
  • 215
    • 80052444598 scopus 로고    scopus 로고
    • Update on anti-angiogenic therapy in non-small cell lung cancer: Are we making progress?
    • Korpanty G, Smyth E, Carney DN (2011) Update on anti-angiogenic therapy in non-small cell lung cancer: are we making progress? J Thorac Dis 3: 19-29.
    • (2011) J Thorac Dis , vol.3 , pp. 19-29
    • Korpanty, G.1    Smyth, E.2    Carney, D.N.3
  • 216
    • 43049130375 scopus 로고    scopus 로고
    • Bevacizumab/chemotherapy in non-small-cell lung cancer: Looking for a few good men?
    • Herbst RS (2008) Bevacizumab/chemotherapy in non-small-cell lung cancer: looking for a few good men? Clin Lung Cancer 9: 75-76.
    • (2008) Clin Lung Cancer , vol.9 , pp. 75-76
    • Herbst, R.S.1
  • 217
    • 80052315962 scopus 로고    scopus 로고
    • Bevacizumab in non-small-cell lung cancer: A review
    • Planchard D (2011) Bevacizumab in non-small-cell lung cancer: a review. Expert Rev Anticancer Ther 11: 1163-1179.
    • (2011) Expert Rev Anticancer Ther , vol.11 , pp. 1163-1179
    • Planchard, D.1
  • 219
    • 62449124416 scopus 로고    scopus 로고
    • Phase III trial of cisplatin plus gemcitabine with either placebo or bevacizumab as first-line therapy for nonsquamous non-small-cell lung cancer: AVAil
    • Reck M, von Pawel J, Zatloukal P, Ramlau R, Gorbounova V, Hirsh V, Leighl N, Mezger J, Archer V, Moore N et al (2009) Phase III trial of cisplatin plus gemcitabine with either placebo or bevacizumab as first-line therapy for nonsquamous non-small-cell lung cancer: AVAil. J Clin Oncol 27: 1227-1234.
    • (2009) J Clin Oncol , vol.27 , pp. 1227-1234
    • Reck, M.1    von Pawel, J.2    Zatloukal, P.3    Ramlau, R.4    Gorbounova, V.5    Hirsh, V.6    Leighl, N.7    Mezger, J.8    Archer, V.9    Moore, N.10
  • 222
    • 79955795090 scopus 로고    scopus 로고
    • A phase II, multicenter, open-label randomized study of motesanib or bevacizumab in combination with paclitaxel and carboplatin for advanced nonsquamous non-small-cell lung cancer
    • Blumenschein GR, Kabbinavar F, Menon H, Mok TS, Stephenson J, Beck JT, Lakshmaiah K, Reckamp K, Hei YJ, Kracht K et al (2011) A phase II, multicenter, open-label randomized study of motesanib or bevacizumab in combination with paclitaxel and carboplatin for advanced nonsquamous non-small-cell lung cancer. Ann Oncol 22: 2057-2067.
    • (2011) Ann Oncol , vol.22 , pp. 2057-2067
    • Blumenschein, G.R.1    Kabbinavar, F.2    Menon, H.3    Mok, T.S.4    Stephenson, J.5    Beck, J.T.6    Lakshmaiah, K.7    Reckamp, K.8    Hei, Y.J.9    Kracht, K.10
  • 223
    • 84873690632 scopus 로고    scopus 로고
    • Anti-angiogenic agents in Non-Small-Cell Lung Cancer (NSCLC): A perspective on the MONET1 (Motesanib NSCLC Efficacy and Tolerability) study
    • Das M, Wakelee H (2012) Anti-angiogenic agents in Non-Small-Cell Lung Cancer (NSCLC): a perspective on the MONET1 (Motesanib NSCLC Efficacy and Tolerability) study. J Thorac Dis 4: 558-561.
    • (2012) J Thorac Dis , vol.4 , pp. 558-561
    • Das, M.1    Wakelee, H.2
  • 224
    • 84865095318 scopus 로고    scopus 로고
    • International, randomized, placebo-controlled, double-blind phase III study of motesanib plus carboplatin/paclitaxel in patients with advanced nonsquamous non-small-cell lung cancer: MONET1
    • Scagliotti GV, Vynnychenko I, Park K, Ichinose Y, Kubota K, Blackhall F, Pirker R, Galiulin R, Ciuleanu TE, Sydorenko O et al (2012) International, randomized, placebo-controlled, double-blind phase III study of motesanib plus carboplatin/paclitaxel in patients with advanced nonsquamous non-small-cell lung cancer: MONET1. J Clin Oncol 30: 2829-2836.
    • (2012) J Clin Oncol , vol.30 , pp. 2829-2836
    • Scagliotti, G.V.1    Vynnychenko, I.2    Park, K.3    Ichinose, Y.4    Kubota, K.5    Blackhall, F.6    Pirker, R.7    Galiulin, R.8    Ciuleanu, T.E.9    Sydorenko, O.10
  • 225
    • 84865721505 scopus 로고    scopus 로고
    • Phase III, randomized, double-blind, placebo-controlled trial of gemcitabine/cisplatin alone or with sorafenib for the first-line treatment of advanced, nonsquamous non-small-cell lung cancer
    • Paz-Ares LG, Biesma B, Heigener D, von Pawel J, Eisen T, Bennouna J, Zhang L, Liao M, Sun Y, Gans S et al (2012) Phase III, randomized, double-blind, placebo-controlled trial of gemcitabine/cisplatin alone or with sorafenib for the first-line treatment of advanced, nonsquamous non-small-cell lung cancer. J Clin Oncol 30: 3084-3092.
    • (2012) J Clin Oncol , vol.30 , pp. 3084-3092
    • Paz-Ares, L.G.1    Biesma, B.2    Heigener, D.3    von Pawel, J.4    Eisen, T.5    Bennouna, J.6    Zhang, L.7    Liao, M.8    Sun, Y.9    Gans, S.10
  • 226
    • 84892967581 scopus 로고    scopus 로고
    • Docetaxel plus nintedanib versus docetaxel plus placebo in patients with previously treated non-small-cell lung cancer (LUME-Lung 1): A phase 3, double-blind, randomised controlled trial
    • Reck M, Kaiser R, Mellemgaard A, Douillard JY, Orlov S, Krzakowski M, von Pawel J, Gottfried M, Bondarenko I, Liao M et al (2014) Docetaxel plus nintedanib versus docetaxel plus placebo in patients with previously treated non-small-cell lung cancer (LUME-Lung 1): a phase 3, double-blind, randomised controlled trial. Lancet Oncol 15: 143-155.
    • (2014) Lancet Oncol , vol.15 , pp. 143-155
    • Reck, M.1    Kaiser, R.2    Mellemgaard, A.3    Douillard, J.Y.4    Orlov, S.5    Krzakowski, M.6    von Pawel, J.7    Gottfried, M.8    Bondarenko, I.9    Liao, M.10
  • 227
    • 80051638135 scopus 로고    scopus 로고
    • Randomized phase III placebo-controlled trial of carboplatin and paclitaxel with or without the vascular disrupting agent vadimezan (ASA404) in advanced non-small-cell lung cancer
    • Lara PN, Douillard JY, Nakagawa K, von Pawel J, McKeage MJ, Albert I, Losonczy G, Reck M, Heo DS, Fan X et al (2011) Randomized phase III placebo-controlled trial of carboplatin and paclitaxel with or without the vascular disrupting agent vadimezan (ASA404) in advanced non-small-cell lung cancer. J Clin Oncol 29: 2965-2971.
    • (2011) J Clin Oncol , vol.29 , pp. 2965-2971
    • Lara, P.N.1    Douillard, J.Y.2    Nakagawa, K.3    von Pawel, J.4    McKeage, M.J.5    Albert, I.6    Losonczy, G.7    Reck, M.8    Heo, D.S.9    Fan, X.10
  • 228
    • 67449123059 scopus 로고    scopus 로고
    • Phase II study of ASA404 (vadimezan, 5, 6-dimethylxanthenone-4-acetic acid/DMXAA) 1800mg/m(2) combined with carboplatin and paclitaxel in previously untreated advanced non-small cell lung cancer
    • McKeage MJ, Reck M, Jameson MB, Rosenthal MA, Gibbs D, Mainwaring PN, Freitag L, Sullivan R, Von Pawel J (2009) Phase II study of ASA404 (vadimezan, 5, 6-dimethylxanthenone-4-acetic acid/DMXAA) 1800mg/m(2) combined with carboplatin and paclitaxel in previously untreated advanced non-small cell lung cancer. Lung Cancer 65: 192-197.
    • (2009) Lung Cancer , vol.65 , pp. 192-197
    • McKeage, M.J.1    Reck, M.2    Jameson, M.B.3    Rosenthal, M.A.4    Gibbs, D.5    Mainwaring, P.N.6    Freitag, L.7    Sullivan, R.8    Von Pawel, J.9
  • 230
    • 84857882376 scopus 로고    scopus 로고
    • Antiangiogenic agents in the management of nonsmall cell lung cancer: Where do we stand now and where are we headed?
    • Aggarwal C, Somaiah N, Simon G (2012) Antiangiogenic agents in the management of nonsmall cell lung cancer: where do we stand now and where are we headed? Cancer Biol Ther 13: 247-263.
    • (2012) Cancer Biol Ther , vol.13 , pp. 247-263
    • Aggarwal, C.1    Somaiah, N.2    Simon, G.3
  • 231
    • 29244449354 scopus 로고    scopus 로고
    • Prostaglandins and cancer
    • Wang D, Dubois RN (2006) Prostaglandins and cancer. Gut 55: 115-122.
    • (2006) Gut , vol.55 , pp. 115-122
    • Wang, D.1    Dubois, R.N.2
  • 232
    • 34247149844 scopus 로고    scopus 로고
    • Nonsteroidal anti-inflammatory drugs and lung cancer risk: A population-based case control study
    • Wall RJ, Shyr Y, Smalley W (2007) Nonsteroidal anti-inflammatory drugs and lung cancer risk: a population-based case control study. J Thorac Oncol 2: 109-114.
    • (2007) J Thorac Oncol , vol.2 , pp. 109-114
    • Wall, R.J.1    Shyr, Y.2    Smalley, W.3
  • 234
    • 84863937925 scopus 로고    scopus 로고
    • Cyclooxygenase-2 (COX-2) as a predictive marker for the use of COX-2 inhibitors in advanced non-small-cell lung cancer
    • author reply 2020
    • Edelman MJ, Hodgson L, Wang X, Kratzke RA, Vokes EE (2012) Cyclooxygenase-2 (COX-2) as a predictive marker for the use of COX-2 inhibitors in advanced non-small-cell lung cancer. J Clin Oncol 30: 2019-2020; author reply 2020.
    • (2012) J Clin Oncol , vol.30 , pp. 2019-2020
    • Edelman, M.J.1    Hodgson, L.2    Wang, X.3    Kratzke, R.A.4    Vokes, E.E.5
  • 235
    • 14944342151 scopus 로고    scopus 로고
    • COX-2 inhibitors-a lesson in unexpected problems
    • Drazen JM (2005) COX-2 inhibitors-a lesson in unexpected problems. N Engl J Med 352: 1131-1132.
    • (2005) N Engl J Med , vol.352 , pp. 1131-1132
    • Drazen, J.M.1
  • 238
    • 84938741949 scopus 로고    scopus 로고
    • Emerging immunotherapies in the treatment of non-small cell lung cancer (NSCLC): The role of immune checkpoint inhibitors
    • Langer CJ (2015) Emerging immunotherapies in the treatment of non-small cell lung cancer (NSCLC): the role of immune checkpoint inhibitors. Am J Clin Oncol 38: 422-30.
    • (2015) Am J Clin Oncol , vol.38 , pp. 422-430
    • Langer, C.J.1
  • 239
    • 78449243490 scopus 로고    scopus 로고
    • Anti-CTLA-4 antibody therapy: Immune monitoring during clinical development of a novel immunotherapy
    • Callahan MK, Wolchok JD, Allison JP (2010) Anti-CTLA-4 antibody therapy: immune monitoring during clinical development of a novel immunotherapy. Semin Oncol 37: 473-484.
    • (2010) Semin Oncol , vol.37 , pp. 473-484
    • Callahan, M.K.1    Wolchok, J.D.2    Allison, J.P.3
  • 241
    • 84866865231 scopus 로고    scopus 로고
    • Squamous-cell carcinomas of the lung: Emerging biology, controversies, and the promise of targeted therapy
    • Drilon A, Rekhtman N, Ladanyi M, Paik P (2012) Squamous-cell carcinomas of the lung: emerging biology, controversies, and the promise of targeted therapy. Lancet Oncol 13: e418-426.
    • (2012) Lancet Oncol , vol.13 , pp. e418-e426
    • Drilon, A.1    Rekhtman, N.2    Ladanyi, M.3    Paik, P.4
  • 242
    • 4243096258 scopus 로고    scopus 로고
    • B7-H1 expression on non-small cell lung cancer cells and its relationship with tumor-infiltrating lymphocytes and their PD-1 expression
    • Konishi J, Yamazaki K, Azuma M, Kinoshita I, Dosaka-Akita H, Nishimura M (2004) B7-H1 expression on non-small cell lung cancer cells and its relationship with tumor-infiltrating lymphocytes and their PD-1 expression. Clin Cancer Res 10: 5094-5100.
    • (2004) Clin Cancer Res , vol.10 , pp. 5094-5100
    • Konishi, J.1    Yamazaki, K.2    Azuma, M.3    Kinoshita, I.4    Dosaka-Akita, H.5    Nishimura, M.6
  • 243
    • 80052476869 scopus 로고    scopus 로고
    • High expression of PD-L1 in lung cancer may contribute to poor prognosis and tumor cells immune escape through suppressing tumor infiltrating dendritic cells maturation
    • Mu CY, Huang JA, Chen Y, Chen C, Zhang XG (2011) High expression of PD-L1 in lung cancer may contribute to poor prognosis and tumor cells immune escape through suppressing tumor infiltrating dendritic cells maturation. Med Oncol 28: 682-688.
    • (2011) Med Oncol , vol.28 , pp. 682-688
    • Mu, C.Y.1    Huang, J.A.2    Chen, Y.3    Chen, C.4    Zhang, X.G.5
  • 244
    • 84894499071 scopus 로고    scopus 로고
    • Immune checkpoint blockade: The hope for immunotherapy as a treatment of lung cancer?
    • Brahmer JR (2014) Immune checkpoint blockade: the hope for immunotherapy as a treatment of lung cancer? Semin Oncol 41: 126-132.
    • (2014) Semin Oncol , vol.41 , pp. 126-132
    • Brahmer, J.R.1
  • 245
    • 84874869077 scopus 로고    scopus 로고
    • Antagonist antibodies to PD-1 and B7-H1 (PD-L1) in the treatment of advanced human cancer
    • Sznol M, Chen L (2013) Antagonist antibodies to PD-1 and B7-H1 (PD-L1) in the treatment of advanced human cancer. Clin Cancer Res 19: 1021-1034.
    • (2013) Clin Cancer Res , vol.19 , pp. 1021-1034
    • Sznol, M.1    Chen, L.2
  • 246
    • 77957664158 scopus 로고    scopus 로고
    • Programmed death-1 upregulation is correlated with dysfunction of tumor-infiltrating CD8+ T lymphocytes in human non-small cell lung cancer
    • Zhang Y, Huang S, Gong D, Qin Y, Shen Q (2010) Programmed death-1 upregulation is correlated with dysfunction of tumor-infiltrating CD8+ T lymphocytes in human non-small cell lung cancer. Cell Mol Immunol 7: 389-395.
    • (2010) Cell Mol Immunol , vol.7 , pp. 389-395
    • Zhang, Y.1    Huang, S.2    Gong, D.3    Qin, Y.4    Shen, Q.5
  • 247
    • 84895812969 scopus 로고    scopus 로고
    • New strategies in lung cancer: Translating immunotherapy into clinical practice
    • Forde PM, Kelly RJ, Brahmer JR (2014) New strategies in lung cancer: translating immunotherapy into clinical practice. Clin Cancer Res 20: 1067-1073.
    • (2014) Clin Cancer Res , vol.20 , pp. 1067-1073
    • Forde, P.M.1    Kelly, R.J.2    Brahmer, J.R.3
  • 248
    • 84863911486 scopus 로고    scopus 로고
    • Ipilimumab in combination with paclitaxel and carboplatin as first-line treatment in stage IIIB/IV non-small-cell lung cancer: Results from a randomized, double-blind, multicenter phase II study
    • Lynch TJ, Bondarenko I, Luft A, Serwatowski P, Barlesi F, Chacko R, Sebastian M, Neal J, Lu H, Cuillerot JM et al (2012) Ipilimumab in combination with paclitaxel and carboplatin as first-line treatment in stage IIIB/IV non-small-cell lung cancer: results from a randomized, double-blind, multicenter phase II study. J Clin Oncol 30: 2046-2054.
    • (2012) J Clin Oncol , vol.30 , pp. 2046-2054
    • Lynch, T.J.1    Bondarenko, I.2    Luft, A.3    Serwatowski, P.4    Barlesi, F.5    Chacko, R.6    Sebastian, M.7    Neal, J.8    Lu, H.9    Cuillerot, J.M.10
  • 249
    • 84899071058 scopus 로고    scopus 로고
    • Pituitary expression of ctla-4 mediates hypophysitis secondary to administration of ctla-4 blocking antibody
    • Iwama S, De Remigis A, Callahan MK, Slovin SF, Wolchok JD, Caturegli P (2014) Pituitary expression of ctla-4 mediates hypophysitis secondary to administration of ctla-4 blocking antibody. Sci Transl Med 6: 230ra245.
    • (2014) Sci Transl Med , vol.6 , pp. 230ra245
    • Iwama, S.1    De Remigis, A.2    Callahan, M.K.3    Slovin, S.F.4    Wolchok, J.D.5    Caturegli, P.6
  • 252
    • 84899709874 scopus 로고    scopus 로고
    • Myeloid-derived suppressor cells in cancer: Therapeutic, predictive, and prognostic implications
    • Diaz-Montero CM, Finke J, Montero AJ (2014) Myeloid-derived suppressor cells in cancer: therapeutic, predictive, and prognostic implications. Semin Oncol 41: 174-184.
    • (2014) Semin Oncol , vol.41 , pp. 174-184
    • Diaz-Montero, C.M.1    Finke, J.2    Montero, A.J.3
  • 253
    • 84877825407 scopus 로고    scopus 로고
    • Therapeutic regulation of myeloid-derived suppressor cells and immune response to cancer vaccine in patients with extensive stage small cell lung cancer
    • Iclozan C, Antonia S, Chiappori A, Chen DT, Gabrilovich D (2013) Therapeutic regulation of myeloid-derived suppressor cells and immune response to cancer vaccine in patients with extensive stage small cell lung cancer. Cancer Immunol Immunother 62: 909-918.
    • (2013) Cancer Immunol Immunother , vol.62 , pp. 909-918
    • Iclozan, C.1    Antonia, S.2    Chiappori, A.3    Chen, D.T.4    Gabrilovich, D.5
  • 254
    • 0037050355 scopus 로고    scopus 로고
    • Lung cancer-time to move on from chemotherapy
    • Carney DN (2002) Lung cancer-time to move on from chemotherapy. N Engl J Med 346: 126-128.
    • (2002) N Engl J Med , vol.346 , pp. 126-128
    • Carney, D.N.1
  • 255
    • 43249095919 scopus 로고    scopus 로고
    • Tumor angiogenesis
    • Kerbel RS (2008) Tumor angiogenesis. N Engl J Med 358: 2039-2049.
    • (2008) N Engl J Med , vol.358 , pp. 2039-2049
    • Kerbel, R.S.1


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