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Volumn 23, Issue 4, 2013, Pages 242-251

Tumors as Organs: Biologically Augmenting Radiation Therapy by Inhibiting Transforming Growth Factor β Activity in Carcinomas

Author keywords

[No Author keywords available]

Indexed keywords

TRANSFORMING GROWTH FACTOR BETA;

EID: 84883493454     PISSN: 10534296     EISSN: 15329461     Source Type: Journal    
DOI: 10.1016/j.semradonc.2013.05.001     Document Type: Article
Times cited : (34)

References (110)
  • 1
    • 84859820567 scopus 로고    scopus 로고
    • Imaging tumor-stroma interactions during chemotherapy reveals contributions of the microenvironment to resistance
    • Nakasone E., Askautrud H., Kees T., et al. Imaging tumor-stroma interactions during chemotherapy reveals contributions of the microenvironment to resistance. Cancer Cell 2012, 21:488-503.
    • (2012) Cancer Cell , vol.21 , pp. 488-503
    • Nakasone, E.1    Askautrud, H.2    Kees, T.3
  • 2
    • 63049104211 scopus 로고    scopus 로고
    • Microenvironmental regulation of metastasis
    • Joyce J., Pollard J. Microenvironmental regulation of metastasis. Nat Rev Cancer 2009, 9:239-252.
    • (2009) Nat Rev Cancer , vol.9 , pp. 239-252
    • Joyce, J.1    Pollard, J.2
  • 3
    • 24644441655 scopus 로고    scopus 로고
    • The role of radiotherapy in cancer treatment: Estimating optimal utilization from a review of evidence-based clinical guidelines
    • Delaney G., Jacob S., Featherstone C., et al. The role of radiotherapy in cancer treatment: Estimating optimal utilization from a review of evidence-based clinical guidelines. Cancer 2005, 104:1129-1137.
    • (2005) Cancer , vol.104 , pp. 1129-1137
    • Delaney, G.1    Jacob, S.2    Featherstone, C.3
  • 4
    • 0038682002 scopus 로고    scopus 로고
    • Mechanisms of TGF-beta signaling from cell membrane to the nucleus
    • Shi Y., Massagué J. Mechanisms of TGF-beta signaling from cell membrane to the nucleus. Cell 2003, 113:685-700.
    • (2003) Cell , vol.113 , pp. 685-700
    • Shi, Y.1    Massagué, J.2
  • 5
    • 0037439630 scopus 로고    scopus 로고
    • Making sense of latent TGF{beta} activation
    • Annes J.P., Munger J.S., Rifkin D.B. Making sense of latent TGF{beta} activation. J Cell Sci 2003, 116:217-224.
    • (2003) J Cell Sci , vol.116 , pp. 217-224
    • Annes, J.P.1    Munger, J.S.2    Rifkin, D.B.3
  • 6
    • 0034785348 scopus 로고    scopus 로고
    • TGF-β signaling in tumor suppression and cancer progression
    • Derynck R., Akhurst R.J., Balmain A. TGF-β signaling in tumor suppression and cancer progression. Nature Genet 2001, 29:117-129.
    • (2001) Nature Genet , vol.29 , pp. 117-129
    • Derynck, R.1    Akhurst, R.J.2    Balmain, A.3
  • 7
    • 14844302670 scopus 로고    scopus 로고
    • Latent transforming growth factor-beta (TGF-beta) binding proteins: Orchestrators of TGF-beta availability
    • Rifkin D. Latent transforming growth factor-beta (TGF-beta) binding proteins: Orchestrators of TGF-beta availability. J Biol Chem 2005, 280:7409-7412.
    • (2005) J Biol Chem , vol.280 , pp. 7409-7412
    • Rifkin, D.1
  • 8
    • 0028806184 scopus 로고
    • Abnormal lung development and cleft palate in mice lacking TGF-β3 indicates defects of epithelial-mesenchymal interaction
    • Kaartinen V., Voncken J.W., Shuler C., et al. Abnormal lung development and cleft palate in mice lacking TGF-β3 indicates defects of epithelial-mesenchymal interaction. Nat. Gen 1995, 11:415-421.
    • (1995) Nat. Gen , vol.11 , pp. 415-421
    • Kaartinen, V.1    Voncken, J.W.2    Shuler, C.3
  • 9
    • 0027217314 scopus 로고
    • Loss of expression of transforming growth factor beta in skin and skin tumors is associated with hyperproliferation and a high risk for malignant conversion
    • Glick A., Kulkarni A., Tennenbaum T., et al. Loss of expression of transforming growth factor beta in skin and skin tumors is associated with hyperproliferation and a high risk for malignant conversion. Proc Natl Acad Sci U S A 1993, 90:6076-6080.
    • (1993) Proc Natl Acad Sci U S A , vol.90 , pp. 6076-6080
    • Glick, A.1    Kulkarni, A.2    Tennenbaum, T.3
  • 10
    • 0030609894 scopus 로고    scopus 로고
    • TGFbeta2 knockout mice have multiple developmental defects that are non-overlapping with other TGFbeta knockout phenotypes
    • Sanford L., Ormsby I., Gittenberger-de G.A., et al. TGFbeta2 knockout mice have multiple developmental defects that are non-overlapping with other TGFbeta knockout phenotypes. Development 1997, 124:2659-2670.
    • (1997) Development , vol.124 , pp. 2659-2670
    • Sanford, L.1    Ormsby, I.2    Gittenberger-de, G.A.3
  • 11
    • 0024994691 scopus 로고
    • Physiochemical activation of recombinant latent transforming growth factor-beta's 1, 2, and 3
    • Brown P.D., Wakefield L.M., Levinson A.D., et al. Physiochemical activation of recombinant latent transforming growth factor-beta's 1, 2, and 3. Growth Factors 1990, 3:35-43.
    • (1990) Growth Factors , vol.3 , pp. 35-43
    • Brown, P.D.1    Wakefield, L.M.2    Levinson, A.D.3
  • 12
    • 84883494654 scopus 로고
    • A novel redox mechanism for TGF-beta activation. Mol Biol Cell
    • Barcellos-Hoff M.H: A novel redox mechanism for TGF-beta activation. Mol Biol Cell 5: 139a, 1994.
    • (1994) , vol.5 , Issue.139 A
    • Barcellos-Hoff, M.H.1
  • 13
    • 0027293946 scopus 로고
    • Radiation-induced transforming growth factor β and subsequent extracellular matrix reorganization in murine mammary gland
    • Barcellos-Hoff M.H. Radiation-induced transforming growth factor β and subsequent extracellular matrix reorganization in murine mammary gland. Cancer Res 1993, 53:3880-3886.
    • (1993) Cancer Res , vol.53 , pp. 3880-3886
    • Barcellos-Hoff, M.H.1
  • 14
    • 0029736871 scopus 로고    scopus 로고
    • Redox-mediated activation of latent transforming growth factor-beta 1
    • Barcellos-Hoff M.H., Dix T.A. Redox-mediated activation of latent transforming growth factor-beta 1. Mol Endocrinol 1996, 10:1077-1083.
    • (1996) Mol Endocrinol , vol.10 , pp. 1077-1083
    • Barcellos-Hoff, M.H.1    Dix, T.A.2
  • 15
    • 3543056882 scopus 로고    scopus 로고
    • Asbestos-derived reactive oxygen species active TGF-β1
    • Pociask D.A., Sime P.J., Brody A.R. Asbestos-derived reactive oxygen species active TGF-β1. Lab Invest 2004, 84:1013-1023.
    • (2004) Lab Invest , vol.84 , pp. 1013-1023
    • Pociask, D.A.1    Sime, P.J.2    Brody, A.R.3
  • 16
    • 33845358508 scopus 로고    scopus 로고
    • Isoform specificity of redox-mediated TGF-β activation
    • Jobling M.F., Mott J.D., Finnegan M., et al. Isoform specificity of redox-mediated TGF-β activation. Radiat Res 2006, 166:839-848.
    • (2006) Radiat Res , vol.166 , pp. 839-848
    • Jobling, M.F.1    Mott, J.D.2    Finnegan, M.3
  • 17
    • 0028177037 scopus 로고
    • Transforming growth factor-β activation in irradiated murine mammary gland
    • Barcellos-Hoff M.H., Derynck R., Tsang M.L.-S., et al. Transforming growth factor-β activation in irradiated murine mammary gland. J Clin Invest 1994, 93:892-899.
    • (1994) J Clin Invest , vol.93 , pp. 892-899
    • Barcellos-Hoff, M.H.1    Derynck, R.2    Tsang, M.L.-S.3
  • 18
    • 0023840825 scopus 로고
    • Modulation of c-myc by transforming growth factor-beta in human colon carcinoma cells
    • Mulder K., Levine A., Hernandez X., et al. Modulation of c-myc by transforming growth factor-beta in human colon carcinoma cells. Biochem Biophys Res Commun 1988, 150:711-716.
    • (1988) Biochem Biophys Res Commun , vol.150 , pp. 711-716
    • Mulder, K.1    Levine, A.2    Hernandez, X.3
  • 19
    • 0037067653 scopus 로고    scopus 로고
    • E2F4/5 and p107 as Smad cofactors linking the TGFbeta receptor to c-myc repression
    • Chen C., Kang Y., Siegel P., et al. E2F4/5 and p107 as Smad cofactors linking the TGFbeta receptor to c-myc repression. Cell 2002, 110:19-32.
    • (2002) Cell , vol.110 , pp. 19-32
    • Chen, C.1    Kang, Y.2    Siegel, P.3
  • 20
    • 0030974040 scopus 로고    scopus 로고
    • Transforming growth factor beta stabilizes p15INK4B protein, increases p15INK4B-cdk4 complexes, and inhibits cyclin D1-cdk4 association in human mammary epithelial cells
    • Sandhu C., Garbe J., Bhattacharya N., et al. Transforming growth factor beta stabilizes p15INK4B protein, increases p15INK4B-cdk4 complexes, and inhibits cyclin D1-cdk4 association in human mammary epithelial cells. Mol Cell Biol 1997, 17:2458-2467.
    • (1997) Mol Cell Biol , vol.17 , pp. 2458-2467
    • Sandhu, C.1    Garbe, J.2    Bhattacharya, N.3
  • 21
    • 0025114866 scopus 로고
    • TGF-beta induces bimodal proliferation of connective tissue cells via complex control of an autocrine PDGF loop
    • Battegay E., Raines E., Seifert R., et al. TGF-beta induces bimodal proliferation of connective tissue cells via complex control of an autocrine PDGF loop. Cell 1990, 63:515-524.
    • (1990) Cell , vol.63 , pp. 515-524
    • Battegay, E.1    Raines, E.2    Seifert, R.3
  • 22
    • 33846821916 scopus 로고    scopus 로고
    • High TGFbeta-Smad activity confers poor prognosis in glioma patients and promotes cell proliferation depending on the methylation of the PDGF-B gene
    • Bruna A., Darken R., Rojo F., et al. High TGFbeta-Smad activity confers poor prognosis in glioma patients and promotes cell proliferation depending on the methylation of the PDGF-B gene. Cancer Cell 2007, 11:147-160.
    • (2007) Cancer Cell , vol.11 , pp. 147-160
    • Bruna, A.1    Darken, R.2    Rojo, F.3
  • 23
    • 10744225133 scopus 로고    scopus 로고
    • SB-431542 and Gleevec inhibit transforming growth factor-beta-induced proliferation of human osteosarcoma cells
    • Matsuyama S., Iwadate M., Kondo M., et al. SB-431542 and Gleevec inhibit transforming growth factor-beta-induced proliferation of human osteosarcoma cells. Cancer Res 2003, 63:7791-7798.
    • (2003) Cancer Res , vol.63 , pp. 7791-7798
    • Matsuyama, S.1    Iwadate, M.2    Kondo, M.3
  • 24
    • 84859456946 scopus 로고    scopus 로고
    • Smoking attenuates transforming growth factor-β-mediated tumor suppression function through downregulation of Smad3 in lung cancer
    • Samanta D., Gonzalez A., Nagathihalli N., et al. Smoking attenuates transforming growth factor-β-mediated tumor suppression function through downregulation of Smad3 in lung cancer. Cancer Prev Res (Phila) 2012, 5:3453-3463.
    • (2012) Cancer Prev Res (Phila) , vol.5 , pp. 3453-3463
    • Samanta, D.1    Gonzalez, A.2    Nagathihalli, N.3
  • 25
    • 0028556486 scopus 로고
    • Genetic changes in the transforming growth factor beta (TGF-beta) type II receptor gene in human gastric cancer cells: Correlation with sensitivity to growth inhibition by TGF-beta
    • Park K., Kim S., Bang Y., et al. Genetic changes in the transforming growth factor beta (TGF-beta) type II receptor gene in human gastric cancer cells: Correlation with sensitivity to growth inhibition by TGF-beta. Proc Natl Acad Sci U S A 1994, 91:8772-8776.
    • (1994) Proc Natl Acad Sci U S A , vol.91 , pp. 8772-8776
    • Park, K.1    Kim, S.2    Bang, Y.3
  • 26
    • 0029066689 scopus 로고
    • Inactivation of the type II TGF-beta receptor in colon cancer cells with microsatellite instability
    • Markowitz S., Wang J., Myeroff L., et al. Inactivation of the type II TGF-beta receptor in colon cancer cells with microsatellite instability. Science 1995, 268:1336-1338.
    • (1995) Science , vol.268 , pp. 1336-1338
    • Markowitz, S.1    Wang, J.2    Myeroff, L.3
  • 27
    • 0030849060 scopus 로고    scopus 로고
    • Mutation analysis of the transforming growth factor-beta type II receptor in human cell lines resistant to growth inhibition by transforming growth factor-beta
    • Vincent F., Nagashima M., Takenoshita S., et al. Mutation analysis of the transforming growth factor-beta type II receptor in human cell lines resistant to growth inhibition by transforming growth factor-beta. Oncogene 1999, 15:117-122.
    • (1999) Oncogene , vol.15 , pp. 117-122
    • Vincent, F.1    Nagashima, M.2    Takenoshita, S.3
  • 28
    • 0034785348 scopus 로고    scopus 로고
    • TGF-beta signaling in tumor suppression and cancer progression
    • Derynck R., Akhurst R., Balmain A. TGF-beta signaling in tumor suppression and cancer progression. Nat Genet 2001, 29:117-129.
    • (2001) Nat Genet , vol.29 , pp. 117-129
    • Derynck, R.1    Akhurst, R.2    Balmain, A.3
  • 29
    • 0031303927 scopus 로고    scopus 로고
    • Transforming growth factor-beta and cancer: A love-hate relationship
    • Reiss M. Transforming growth factor-beta and cancer: A love-hate relationship. Oncol Res 1997, 9:9447-9457.
    • (1997) Oncol Res , vol.9 , pp. 9447-9457
    • Reiss, M.1
  • 30
    • 47549090432 scopus 로고    scopus 로고
    • TGFbeta in cancer
    • Massagué J. TGFbeta in cancer. Cell 2008, 134:215-230.
    • (2008) Cell , vol.134 , pp. 215-230
    • Massagué, J.1
  • 31
    • 0022891340 scopus 로고
    • Tumors: Wounds that do not heal. Similarities between tumor stroma generation and wound healing
    • Dvorak H. Tumors: Wounds that do not heal. Similarities between tumor stroma generation and wound healing. N Engl J Med 1986, 315:1650-1659.
    • (1986) N Engl J Med , vol.315 , pp. 1650-1659
    • Dvorak, H.1
  • 32
    • 0028109801 scopus 로고
    • Transforming growth factor beta in tissue fibrosis
    • Border W., Noble N. Transforming growth factor beta in tissue fibrosis. N Engl J Med 1994, 331:1286-1292.
    • (1994) N Engl J Med , vol.331 , pp. 1286-1292
    • Border, W.1    Noble, N.2
  • 33
    • 73149098919 scopus 로고    scopus 로고
    • Transforming growth factor-beta signaling across ages: From distorted lung development to chronic obstructive pulmonary disease
    • Morty R., Königshoff M., Eickelberg O. Transforming growth factor-beta signaling across ages: From distorted lung development to chronic obstructive pulmonary disease. Proc Am Thorac Soc 2009, 6:607-613.
    • (2009) Proc Am Thorac Soc , vol.6 , pp. 607-613
    • Morty, R.1    Königshoff, M.2    Eickelberg, O.3
  • 34
    • 9144272598 scopus 로고    scopus 로고
    • Migration-stimulating factor: A genetically truncated onco-fetal fibronectin isoform expressed by carcinoma and tumor-associated stromal cells
    • Schor S., Ellis I., Jones S., et al. Migration-stimulating factor: A genetically truncated onco-fetal fibronectin isoform expressed by carcinoma and tumor-associated stromal cells. Cancer Res 2003, 63:8827-8836.
    • (2003) Cancer Res , vol.63 , pp. 8827-8836
    • Schor, S.1    Ellis, I.2    Jones, S.3
  • 35
    • 36749013537 scopus 로고    scopus 로고
    • Fibroblast-led collective invasion of carcinoma cells with differing roles for RhoGTPases in leading and following cells
    • Gaggioli C., Hooper S., Hidalgo-Carcedo C., et al. Fibroblast-led collective invasion of carcinoma cells with differing roles for RhoGTPases in leading and following cells. Nat Cell Biol 2007, 9:1392-1400.
    • (2007) Nat Cell Biol , vol.9 , pp. 1392-1400
    • Gaggioli, C.1    Hooper, S.2    Hidalgo-Carcedo, C.3
  • 36
    • 79751501829 scopus 로고    scopus 로고
    • Bone marrow-derived myofibroblasts contribute to the mesenchymal stem cell niche and promote tumor growth
    • Quante M., Tu S., Tomita H., et al. Bone marrow-derived myofibroblasts contribute to the mesenchymal stem cell niche and promote tumor growth. Cancer Cell 2011, 19:257-272.
    • (2011) Cancer Cell , vol.19 , pp. 257-272
    • Quante, M.1    Tu, S.2    Tomita, H.3
  • 37
    • 53449094862 scopus 로고    scopus 로고
    • Stromal myofibroblasts are drivers of invasive cancer growth
    • De Wever O., Demetter P., Mareel M., et al. Stromal myofibroblasts are drivers of invasive cancer growth. Int J Cancer 2008, 123:2229-2238.
    • (2008) Int J Cancer , vol.123 , pp. 2229-2238
    • De Wever, O.1    Demetter, P.2    Mareel, M.3
  • 38
    • 0036828120 scopus 로고    scopus 로고
    • Inhibition of transforming growth factor-beta activity decreases angiogenesis in a human prostate cancer-reactive stroma xenograft model
    • Tuxhorn J., McAlhany S., Yang F., et al. Inhibition of transforming growth factor-beta activity decreases angiogenesis in a human prostate cancer-reactive stroma xenograft model. Cancer Res 2002, 62:6021-6025.
    • (2002) Cancer Res , vol.62 , pp. 6021-6025
    • Tuxhorn, J.1    McAlhany, S.2    Yang, F.3
  • 39
    • 0027161705 scopus 로고    scopus 로고
    • Induction of alpha-smooth muscle actin by transforming growth factor-beta 1 in quiescent human breast gland fibroblasts. Implications for myofibroblast generation in breast neoplasia
    • Rønnov-Jessen L., Petersen O. Induction of alpha-smooth muscle actin by transforming growth factor-beta 1 in quiescent human breast gland fibroblasts. Implications for myofibroblast generation in breast neoplasia. Lab Invest 1996, 68:696-707.
    • (1996) Lab Invest , vol.68 , pp. 696-707
    • Rønnov-Jessen, L.1    Petersen, O.2
  • 40
    • 70350746065 scopus 로고    scopus 로고
    • TGF-beta induces fibroblast activation protein expression; fibroblast activation protein expression increases the proliferation, adhesion, and migration of HO-8910PM
    • Chen H., Yang W., Wen Q., et al. TGF-beta induces fibroblast activation protein expression; fibroblast activation protein expression increases the proliferation, adhesion, and migration of HO-8910PM. Exp Mol Pathol 2009, 87:189-194.
    • (2009) Exp Mol Pathol , vol.87 , pp. 189-194
    • Chen, H.1    Yang, W.2    Wen, Q.3
  • 41
    • 77957326048 scopus 로고    scopus 로고
    • Identification and characterization of the promoter of fibroblast activation protein
    • Zhang J., Valianou M., Cheng J. Identification and characterization of the promoter of fibroblast activation protein. Front Biosci (Elite Ed) 2010, 2:1154-1163.
    • (2010) Front Biosci (Elite Ed) , vol.2 , pp. 1154-1163
    • Zhang, J.1    Valianou, M.2    Cheng, J.3
  • 42
    • 78650563018 scopus 로고    scopus 로고
    • Autocrine TGF-beta and stromal cell-derived factor-1 (SDF-1) signaling drives the evolution of tumor-promoting mammary stromal myofibroblasts
    • Kojima Y., Acar A., Eaton E., et al. Autocrine TGF-beta and stromal cell-derived factor-1 (SDF-1) signaling drives the evolution of tumor-promoting mammary stromal myofibroblasts. Proc Natl Acad Sci U S A 2010, 46:20009-20014.
    • (2010) Proc Natl Acad Sci U S A , vol.46 , pp. 20009-20014
    • Kojima, Y.1    Acar, A.2    Eaton, E.3
  • 43
    • 18844428327 scopus 로고    scopus 로고
    • Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion
    • Orimo A., Gupta P., Sgroi D., et al. Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion. Cell 2005, 121:335-348.
    • (2005) Cell , vol.121 , pp. 335-348
    • Orimo, A.1    Gupta, P.2    Sgroi, D.3
  • 44
    • 0035835829 scopus 로고    scopus 로고
    • Heterotypic signaling between epithelial tumor cells and fibroblasts in carcinoma formation
    • Elenbaas B., Weinberg R. Heterotypic signaling between epithelial tumor cells and fibroblasts in carcinoma formation. Exp Cell Res 2001, 264:169-184.
    • (2001) Exp Cell Res , vol.264 , pp. 169-184
    • Elenbaas, B.1    Weinberg, R.2
  • 45
    • 35448991324 scopus 로고    scopus 로고
    • Extracellular control of TGFβ signalling in vascular development and disease
    • ten Dijke P., Arthur H. Extracellular control of TGFβ signalling in vascular development and disease. Nat Rev Mol Cell Biol 2007, 8:857-869.
    • (2007) Nat Rev Mol Cell Biol , vol.8 , pp. 857-869
    • ten Dijke, P.1    Arthur, H.2
  • 46
    • 0242330126 scopus 로고    scopus 로고
    • Activin receptor-like kinase (ALK)1 is an antagonistic mediator of lateral TGFbeta/ALK5 signaling
    • Goumans M., Valdimarsdottir G., Itoh S., et al. Activin receptor-like kinase (ALK)1 is an antagonistic mediator of lateral TGFbeta/ALK5 signaling. Mol Cell 2003, 12:817-828.
    • (2003) Mol Cell , vol.12 , pp. 817-828
    • Goumans, M.1    Valdimarsdottir, G.2    Itoh, S.3
  • 47
    • 12944273545 scopus 로고    scopus 로고
    • Activin receptor-like kinase 1 modulates transforming growth factor-beta 1 signaling in the regulation of angiogenesis
    • Oh S., Seki T., Goss K., et al. Activin receptor-like kinase 1 modulates transforming growth factor-beta 1 signaling in the regulation of angiogenesis. Proc Natl Acad Sci U S A 2000, 97:2626-2631.
    • (2000) Proc Natl Acad Sci U S A , vol.97 , pp. 2626-2631
    • Oh, S.1    Seki, T.2    Goss, K.3
  • 48
    • 8144230707 scopus 로고    scopus 로고
    • Endoglin promotes endothelial cell proliferation and TGF-beta/ALK1 signal transduction
    • Lebrin F., Goumans M., Jonker L., et al. Endoglin promotes endothelial cell proliferation and TGF-beta/ALK1 signal transduction. EMBO J 2004, 23:4018-4028.
    • (2004) EMBO J , vol.23 , pp. 4018-4028
    • Lebrin, F.1    Goumans, M.2    Jonker, L.3
  • 49
    • 70350059078 scopus 로고    scopus 로고
    • Inhibition of transforming growth factor beta receptor I kinase blocks hepatocellular carcinoma growth through neo-angiogenesis regulation
    • Mazzocca A., Fransvea E., Lavezzari G., et al. Inhibition of transforming growth factor beta receptor I kinase blocks hepatocellular carcinoma growth through neo-angiogenesis regulation. Hepatology 2009, 50:1140-1151.
    • (2009) Hepatology , vol.50 , pp. 1140-1151
    • Mazzocca, A.1    Fransvea, E.2    Lavezzari, G.3
  • 50
    • 0033032231 scopus 로고    scopus 로고
    • Role of interleukin 10 and transforming growth factor beta1 in the angiogenesis and metastasis of human prostate primary tumor lines from orthotopic implants in severe combined immunodeficiency mice
    • Stearns M., Garcia F., Fudge K., et al. Role of interleukin 10 and transforming growth factor beta1 in the angiogenesis and metastasis of human prostate primary tumor lines from orthotopic implants in severe combined immunodeficiency mice. Clin Cancer Res 1999, 5:3711-3720.
    • (1999) Clin Cancer Res , vol.5 , pp. 3711-3720
    • Stearns, M.1    Garcia, F.2    Fudge, K.3
  • 51
    • 0033135109 scopus 로고    scopus 로고
    • Transforming growth factor beta1 is a target for the von Hippel-Lindau tumor suppressor and a critical growth factor for clear cell renal carcinoma
    • Ananth S., Knebelmann B., Grüning W., et al. Transforming growth factor beta1 is a target for the von Hippel-Lindau tumor suppressor and a critical growth factor for clear cell renal carcinoma. Cancer Res 1999, 59:2210-2216.
    • (1999) Cancer Res , vol.59 , pp. 2210-2216
    • Ananth, S.1    Knebelmann, B.2    Grüning, W.3
  • 52
    • 79952728354 scopus 로고    scopus 로고
    • TGF-beta blockade controls ascites by preventing abnormalization of lymphatic vessels in orthotopic human ovarian carcinoma models
    • Liao S., Liu J., Lin P., et al. TGF-beta blockade controls ascites by preventing abnormalization of lymphatic vessels in orthotopic human ovarian carcinoma models. Clin Cancer Res 2011, 17:1415-1424.
    • (2011) Clin Cancer Res , vol.17 , pp. 1415-1424
    • Liao, S.1    Liu, J.2    Lin, P.3
  • 53
    • 0038488950 scopus 로고    scopus 로고
    • A multigenic program mediating breast cancer metastasis to bone
    • Kang Y., Siegel P., Shu W., et al. A multigenic program mediating breast cancer metastasis to bone. Cancer Cell 2003, 3:537-549.
    • (2003) Cancer Cell , vol.3 , pp. 537-549
    • Kang, Y.1    Siegel, P.2    Shu, W.3
  • 54
    • 0035914297 scopus 로고    scopus 로고
    • Synergistic cooperation between hypoxia and transforming growth factor-beta pathways on human vascular endothelial growth factor gene expression
    • Sánchez-Elsner T., Botella L., Velasco B., et al. Synergistic cooperation between hypoxia and transforming growth factor-beta pathways on human vascular endothelial growth factor gene expression. J Biol Chem 2001, 276:38527-38535.
    • (2001) J Biol Chem , vol.276 , pp. 38527-38535
    • Sánchez-Elsner, T.1    Botella, L.2    Velasco, B.3
  • 55
    • 0032742092 scopus 로고    scopus 로고
    • Glucocorticoid receptor inhibits transforming growth factor-beta signaling by directly targeting the transcriptional activation function of Smad3
    • Song C.X.T., Gelehrter T. Glucocorticoid receptor inhibits transforming growth factor-beta signaling by directly targeting the transcriptional activation function of Smad3. Proc Natl Acad Sci U S A 1999, 96:11776-11781.
    • (1999) Proc Natl Acad Sci U S A , vol.96 , pp. 11776-11781
    • Song, C.X.T.1    Gelehrter, T.2
  • 56
    • 63149088164 scopus 로고    scopus 로고
    • Trophic macrophages in development and disease
    • Pollard J. Trophic macrophages in development and disease. Nat Rev Immunol 2009, 9:259-270.
    • (2009) Nat Rev Immunol , vol.9 , pp. 259-270
    • Pollard, J.1
  • 57
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: The next generation
    • Hanahan D., Weinberg R. Hallmarks of cancer: The next generation. Cell 2011, 144:646-674.
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.2
  • 58
    • 76349088502 scopus 로고    scopus 로고
    • FcRgamma activation regulates inflammation-associated squamous carcinogenesis
    • Andreu P., Johansson M., Affara N., et al. FcRgamma activation regulates inflammation-associated squamous carcinogenesis. Cancer Cell 2010, 17:121-134.
    • (2010) Cancer Cell , vol.17 , pp. 121-134
    • Andreu, P.1    Johansson, M.2    Affara, N.3
  • 59
    • 77953023274 scopus 로고    scopus 로고
    • TGF-beta and immune cells: An important regulatory axis in the tumor microenvironment and progression
    • Yang L., Pang Y., Moses H. TGF-beta and immune cells: An important regulatory axis in the tumor microenvironment and progression. Trends Immunol 2010, 31:220-227.
    • (2010) Trends Immunol , vol.31 , pp. 220-227
    • Yang, L.1    Pang, Y.2    Moses, H.3
  • 60
    • 39849102836 scopus 로고    scopus 로고
    • HIF1alpha induces the recruitment of bone marrow-derived vascular modulatory cells to regulate tumor angiogenesis and invasion
    • Du R., Lu K., Petritsch C., et al. HIF1alpha induces the recruitment of bone marrow-derived vascular modulatory cells to regulate tumor angiogenesis and invasion. Cancer Cell 2008, 13:206-220.
    • (2008) Cancer Cell , vol.13 , pp. 206-220
    • Du, R.1    Lu, K.2    Petritsch, C.3
  • 61
    • 4644335311 scopus 로고    scopus 로고
    • Cancer: An inflammatory link
    • Balkwill F., Coussens L. Cancer: An inflammatory link. Nature 2004, 431:405-406.
    • (2004) Nature , vol.431 , pp. 405-406
    • Balkwill, F.1    Coussens, L.2
  • 62
    • 39749114978 scopus 로고    scopus 로고
    • Hypoxia and metabolism. Hypoxia, DNA repair and genetic instability
    • Bristow R., Hill R. Hypoxia and metabolism. Hypoxia, DNA repair and genetic instability. Nat Rev Cancer 2008, 8:180-192.
    • (2008) Nat Rev Cancer , vol.8 , pp. 180-192
    • Bristow, R.1    Hill, R.2
  • 63
    • 33748756028 scopus 로고    scopus 로고
    • TGF-beta: A mobile purveyor of immune privilege
    • Wahl S., Wen J., Moutsopoulos N. TGF-beta: A mobile purveyor of immune privilege. Immunol Rev 2006, 213:213-227.
    • (2006) Immunol Rev , vol.213 , pp. 213-227
    • Wahl, S.1    Wen, J.2    Moutsopoulos, N.3
  • 64
    • 27644457376 scopus 로고    scopus 로고
    • TGF-beta directly targets cytotoxic T cell functions during tumor evasion of immune surveillance
    • Thomas D., Massagué J. TGF-beta directly targets cytotoxic T cell functions during tumor evasion of immune surveillance. Cancer Cell 2005, 8:369-380.
    • (2005) Cancer Cell , vol.8 , pp. 369-380
    • Thomas, D.1    Massagué, J.2
  • 65
    • 26844464792 scopus 로고    scopus 로고
    • CD4+CD25+ regulatory T cells inhibit natural killer cell functions in a transforming growth factor-beta-dependent manner
    • Ghiringhelli F., Ménard C., Terme M., et al. CD4+CD25+ regulatory T cells inhibit natural killer cell functions in a transforming growth factor-beta-dependent manner. J Exp Med 2005, 202:1075-1085.
    • (2005) J Exp Med , vol.202 , pp. 1075-1085
    • Ghiringhelli, F.1    Ménard, C.2    Terme, M.3
  • 66
    • 71449127523 scopus 로고    scopus 로고
    • Population alterations of l-arginase- and inducible nitric oxide synthase-expressed CD11b+/CD14-[U+207B]/CD15+/CD33+ myeloid-derived suppressor cells and CD8+ T lymphocytes in patients with advanced-stage non-small cell lung cancer
    • Liu C., Wang Y., Wang C., et al. Population alterations of l-arginase- and inducible nitric oxide synthase-expressed CD11b+/CD14-[U+207B]/CD15+/CD33+ myeloid-derived suppressor cells and CD8+ T lymphocytes in patients with advanced-stage non-small cell lung cancer. J Cancer Res Clin Oncol 2010, 136:35-45.
    • (2010) J Cancer Res Clin Oncol , vol.136 , pp. 35-45
    • Liu, C.1    Wang, Y.2    Wang, C.3
  • 67
    • 84857692141 scopus 로고    scopus 로고
    • Differential macrophage programming in the tumor microenvironment
    • Ruffell B., Affara N., Coussens L. Differential macrophage programming in the tumor microenvironment. Trends Immunol 2012, 33:119-126.
    • (2012) Trends Immunol , vol.33 , pp. 119-126
    • Ruffell, B.1    Affara, N.2    Coussens, L.3
  • 68
    • 69249222379 scopus 로고    scopus 로고
    • Polarization of tumor-associated neutrophil phenotype by TGF-beta: "N1" versus "N2" TAN
    • Fridlender Z., Sun J., Kim S., et al. Polarization of tumor-associated neutrophil phenotype by TGF-beta: "N1" versus "N2" TAN. Cancer Cell 2009, 16:183-194.
    • (2009) Cancer Cell , vol.16 , pp. 183-194
    • Fridlender, Z.1    Sun, J.2    Kim, S.3
  • 69
    • 34248384441 scopus 로고    scopus 로고
    • Dose-dependent cross-talk between the transforming growth factor-beta and interleukin-1 signaling pathways
    • Lu T., Tian L., Han Y., et al. Dose-dependent cross-talk between the transforming growth factor-beta and interleukin-1 signaling pathways. Proc Natl Acad Sci U S A 2007, 104:4365-4370.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 4365-4370
    • Lu, T.1    Tian, L.2    Han, Y.3
  • 70
    • 33750795581 scopus 로고    scopus 로고
    • CD4+CXCR4highCD69+ T cells accumulate in lung adenocarcinoma
    • Wald O., Izhar U., Amir G., et al. CD4+CXCR4highCD69+ T cells accumulate in lung adenocarcinoma. J Immunol 2006, 177:6983-6990.
    • (2006) J Immunol , vol.177 , pp. 6983-6990
    • Wald, O.1    Izhar, U.2    Amir, G.3
  • 71
    • 77949697909 scopus 로고    scopus 로고
    • Inhibition of vasculogenesis, but not angiogenesis, prevents the recurrence of glioblastoma after irradiation in mice
    • Kioi M., Vogel H., Schultz G., et al. Inhibition of vasculogenesis, but not angiogenesis, prevents the recurrence of glioblastoma after irradiation in mice. J Clin Invest 2010, 120:694-705.
    • (2010) J Clin Invest , vol.120 , pp. 694-705
    • Kioi, M.1    Vogel, H.2    Schultz, G.3
  • 72
    • 77449159691 scopus 로고    scopus 로고
    • Inactivation of kupffer cells by gadolinium chloride protects murine liver from radiation-induced apoptosis
    • Du S., Qiang M., Zeng Z., et al. Inactivation of kupffer cells by gadolinium chloride protects murine liver from radiation-induced apoptosis. Int J Radiat Oncol Biol Phys 2010, 76:1225-1234.
    • (2010) Int J Radiat Oncol Biol Phys , vol.76 , pp. 1225-1234
    • Du, S.1    Qiang, M.2    Zeng, Z.3
  • 73
    • 0037108674 scopus 로고    scopus 로고
    • Transforming growth factor-β1 mediates cellular response to DNA damage in situ
    • Ewan K.B., Henshall-Powell R.L., Ravani S.A., et al. Transforming growth factor-β1 mediates cellular response to DNA damage in situ. Cancer Res 2002, 62:5627-5631.
    • (2002) Cancer Res , vol.62 , pp. 5627-5631
    • Ewan, K.B.1    Henshall-Powell, R.L.2    Ravani, S.A.3
  • 74
    • 33845303212 scopus 로고    scopus 로고
    • Inhibition of transforming growth factor-beta1 signaling attenuates ataxia telangiectasia mutated activity in response to genotoxic stress
    • Kirshner J., Jobling M., Pajares M., et al. Inhibition of transforming growth factor-beta1 signaling attenuates ataxia telangiectasia mutated activity in response to genotoxic stress. Cancer Res 2006, 66:10861-10869.
    • (2006) Cancer Res , vol.66 , pp. 10861-10869
    • Kirshner, J.1    Jobling, M.2    Pajares, M.3
  • 75
    • 0037829284 scopus 로고    scopus 로고
    • Checkpoint signaling: Epigenetic events sound the DNA strand-breaks alarm to the ATM protein kinase
    • Abraham R.T. Checkpoint signaling: Epigenetic events sound the DNA strand-breaks alarm to the ATM protein kinase. Bioessays 2003, 25:627-630.
    • (2003) Bioessays , vol.25 , pp. 627-630
    • Abraham, R.T.1
  • 77
    • 34250189244 scopus 로고    scopus 로고
    • TGFbeta-1 dependent fast stimulation of ATM and p53 phosphorylation following exposure to ionizing radiation does not involve TGFbeta-receptor I signalling
    • Wiegman E.M., Blaese M.A., Loeffler H., et al. TGFbeta-1 dependent fast stimulation of ATM and p53 phosphorylation following exposure to ionizing radiation does not involve TGFbeta-receptor I signalling. Radiother Oncol 2007, 83:289-295.
    • (2007) Radiother Oncol , vol.83 , pp. 289-295
    • Wiegman, E.M.1    Blaese, M.A.2    Loeffler, H.3
  • 78
    • 80455144497 scopus 로고    scopus 로고
    • TGFβ1 inhibition increases the radiosensitivity of breast cancer cells in vitro and promotes tumor control by radiation in vivo
    • Bouquet F., Pal A., Pilones K., et al. TGFβ1 inhibition increases the radiosensitivity of breast cancer cells in vitro and promotes tumor control by radiation in vivo. Clin Cancer Res 2011, 17:6754-6765.
    • (2011) Clin Cancer Res , vol.17 , pp. 6754-6765
    • Bouquet, F.1    Pal, A.2    Pilones, K.3
  • 79
    • 84865140762 scopus 로고    scopus 로고
    • Resistance of glioblastoma-initiating cells to radiation mediated by the tumor microenvironment can be abolished by inhibiting transforming growth factor-β
    • Hardee M., Marciscano A., Medina-Ramirez C., et al. Resistance of glioblastoma-initiating cells to radiation mediated by the tumor microenvironment can be abolished by inhibiting transforming growth factor-β. Cancer Res 2012, 72:4119-4129.
    • (2012) Cancer Res , vol.72 , pp. 4119-4129
    • Hardee, M.1    Marciscano, A.2    Medina-Ramirez, C.3
  • 80
    • 39849100541 scopus 로고    scopus 로고
    • Matrix metalloproteinase-9 is required for tumor vasculogenesis but not for angiogenesis: Role of bone marrow-derived myelomonocytic cells
    • Ahn G., Brown J. Matrix metalloproteinase-9 is required for tumor vasculogenesis but not for angiogenesis: Role of bone marrow-derived myelomonocytic cells. Cancer Cell 2008, 13:193-205.
    • (2008) Cancer Cell , vol.13 , pp. 193-205
    • Ahn, G.1    Brown, J.2
  • 81
    • 0034032882 scopus 로고    scopus 로고
    • Antiangiogenic scheduling of chemotherapy improves efficacy against experimental drug-resistant cancer
    • Browder T., Butterfield C., Kräling B., et al. Antiangiogenic scheduling of chemotherapy improves efficacy against experimental drug-resistant cancer. Cancer Res 2000, 60:1878-1886.
    • (2000) Cancer Res , vol.60 , pp. 1878-1886
    • Browder, T.1    Butterfield, C.2    Kräling, B.3
  • 82
    • 0035854479 scopus 로고    scopus 로고
    • Endothelial apoptosis as the primary lesion initiating intestinal radiation damage in mice
    • Paris F., Fuks Z., Kang A., et al. Endothelial apoptosis as the primary lesion initiating intestinal radiation damage in mice. Science 2001, 293:293-297.
    • (2001) Science , vol.293 , pp. 293-297
    • Paris, F.1    Fuks, Z.2    Kang, A.3
  • 83
    • 84864349474 scopus 로고    scopus 로고
    • Tumor radiation response enhancement by acoustical stimulation of the vasculature
    • Czarnota G., Karshafian R., Burns P., et al. Tumor radiation response enhancement by acoustical stimulation of the vasculature. Proc Natl Acad Sci U S A 2012, 109:E2033-E2041.
    • (2012) Proc Natl Acad Sci U S A , vol.109
    • Czarnota, G.1    Karshafian, R.2    Burns, P.3
  • 84
    • 0038626211 scopus 로고    scopus 로고
    • Tumor response to radiotherapy regulated by endothelial cell apoptosis
    • Garcia-Barros M., Paris F., Cordon-Cardo C., et al. Tumor response to radiotherapy regulated by endothelial cell apoptosis. Science 2003, 300:1155-1159.
    • (2003) Science , vol.300 , pp. 1155-1159
    • Garcia-Barros, M.1    Paris, F.2    Cordon-Cardo, C.3
  • 86
    • 79960041859 scopus 로고    scopus 로고
    • Genetic variations in the transforming growth factor-beta pathway as predictors of survival in advanced non-small cell lung cancer
    • Lin M., Stewart D., Spitz M., et al. Genetic variations in the transforming growth factor-beta pathway as predictors of survival in advanced non-small cell lung cancer. Carcinogenesis 2011, 32:1050-1056.
    • (2011) Carcinogenesis , vol.32 , pp. 1050-1056
    • Lin, M.1    Stewart, D.2    Spitz, M.3
  • 87
    • 84859862408 scopus 로고    scopus 로고
    • Loss of transforming growth factor beta type II receptor increases aggressive tumor behavior and reduces survival in lung adenocarcinoma and squamous cell carcinoma
    • Malkoski S., Haeger S., Cleaver T., et al. Loss of transforming growth factor beta type II receptor increases aggressive tumor behavior and reduces survival in lung adenocarcinoma and squamous cell carcinoma. Clin Cancer Res 2012, 18:2173-2183.
    • (2012) Clin Cancer Res , vol.18 , pp. 2173-2183
    • Malkoski, S.1    Haeger, S.2    Cleaver, T.3
  • 88
    • 34548591598 scopus 로고    scopus 로고
    • Defective expression of transforming growth factor beta type II receptor (TGFBR2) in the large cell variant of non-small cell lung carcinoma
    • Xu J., Bao Y., Liu X., et al. Defective expression of transforming growth factor beta type II receptor (TGFBR2) in the large cell variant of non-small cell lung carcinoma. Lung Cancer 2007, 58:36-43.
    • (2007) Lung Cancer , vol.58 , pp. 36-43
    • Xu, J.1    Bao, Y.2    Liu, X.3
  • 89
    • 1842479071 scopus 로고    scopus 로고
    • Defective expression of transforming growth factor beta receptor type II is associated with CpG methylated promoter in primary non-small cell lung cancer
    • Zhang H., Chen X., Wang M., et al. Defective expression of transforming growth factor beta receptor type II is associated with CpG methylated promoter in primary non-small cell lung cancer. Clin Cancer Res 2004, 10:2359-2367.
    • (2004) Clin Cancer Res , vol.10 , pp. 2359-2367
    • Zhang, H.1    Chen, X.2    Wang, M.3
  • 90
    • 0032897720 scopus 로고    scopus 로고
    • Reduced transforming growth factor-beta type II receptor (TGF-beta RII) expression in adenocarcinoma of the lung
    • Kim W., Park C., Jung Y., et al. Reduced transforming growth factor-beta type II receptor (TGF-beta RII) expression in adenocarcinoma of the lung. Anticancer Res 1999, 9:301-306.
    • (1999) Anticancer Res , vol.9 , pp. 301-306
    • Kim, W.1    Park, C.2    Jung, Y.3
  • 91
    • 72849125358 scopus 로고    scopus 로고
    • Targeting fibroblast activation protein inhibits tumor stromagenesis and growth in mice
    • Santos A., Jung J., Aziz N., et al. Targeting fibroblast activation protein inhibits tumor stromagenesis and growth in mice. J Clin Invest 2009, 119:3613-3625.
    • (2009) J Clin Invest , vol.119 , pp. 3613-3625
    • Santos, A.1    Jung, J.2    Aziz, N.3
  • 92
    • 45049088723 scopus 로고    scopus 로고
    • Differential impact of TGF-beta and EGF on fibroblast differentiation and invasion reciprocally promotes colon cancer cell invasion
    • Denys H., Derycke L., Hendrix A., et al. Differential impact of TGF-beta and EGF on fibroblast differentiation and invasion reciprocally promotes colon cancer cell invasion. Cancer Lett 2008, 266:263-274.
    • (2008) Cancer Lett , vol.266 , pp. 263-274
    • Denys, H.1    Derycke, L.2    Hendrix, A.3
  • 93
    • 78149298209 scopus 로고    scopus 로고
    • Suppression of antitumor immunity by stromal cells expressing fibroblast activation protein-alpha
    • Kraman M., Bambrough P., Arnold J., et al. Suppression of antitumor immunity by stromal cells expressing fibroblast activation protein-alpha. Science 2010, 330:827-830.
    • (2010) Science , vol.330 , pp. 827-830
    • Kraman, M.1    Bambrough, P.2    Arnold, J.3
  • 94
    • 79955562722 scopus 로고    scopus 로고
    • Prognostic gene-expression signature of carcinoma-associated fibroblasts in non-small cell lung cancer
    • Navab R., Strumpf D., Bandarchi B., et al. Prognostic gene-expression signature of carcinoma-associated fibroblasts in non-small cell lung cancer. Proc Natl Acad Sci U S A 2011, 108:7160-7165.
    • (2011) Proc Natl Acad Sci U S A , vol.108 , pp. 7160-7165
    • Navab, R.1    Strumpf, D.2    Bandarchi, B.3
  • 95
    • 0035281783 scopus 로고    scopus 로고
    • Transforming growth factor-beta1 level correlates with angiogenesis, tumor progression, and prognosis in patients with nonsmall cell lung carcinoma
    • Hasegawa Y., Takanashi S., Kanehira Y., et al. Transforming growth factor-beta1 level correlates with angiogenesis, tumor progression, and prognosis in patients with nonsmall cell lung carcinoma. Cancer 2001, 91:964-971.
    • (2001) Cancer , vol.91 , pp. 964-971
    • Hasegawa, Y.1    Takanashi, S.2    Kanehira, Y.3
  • 96
    • 36148992949 scopus 로고    scopus 로고
    • The role of bevacizumab in the treatment of non-small cell lung cancer: Current indications and future developments
    • Gridelli C., Maione P., Rossi A., et al. The role of bevacizumab in the treatment of non-small cell lung cancer: Current indications and future developments. Oncologist 2007, 12:1183-1193.
    • (2007) Oncologist , vol.12 , pp. 1183-1193
    • Gridelli, C.1    Maione, P.2    Rossi, A.3
  • 97
    • 33845490014 scopus 로고    scopus 로고
    • Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer
    • S A., Gray R., Perry M., et al. Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer. N Engl J Med 2006, 355:2542-2550.
    • (2006) N Engl J Med , vol.355 , pp. 2542-2550
    • S, A.1    Gray, R.2    Perry, M.3
  • 98
    • 58249134743 scopus 로고    scopus 로고
    • Clinical significance of tumor-infiltrating lymphocytes in lung neoplasms
    • Ruffini E., A S., Filosso P., et al. Clinical significance of tumor-infiltrating lymphocytes in lung neoplasms. Ann Thorac Surg 2009, 87:365-371.
    • (2009) Ann Thorac Surg , vol.87 , pp. 365-371
    • Ruffini, E.1    A, S.2    Filosso, P.3
  • 99
    • 31444439350 scopus 로고    scopus 로고
    • Concurrent infiltration by CD8+ T cells and CD4+ T cells is a favourable prognostic factor in non-small-cell lung carcinoma
    • Hiraoka K., Miyamoto M., Cho Y., et al. Concurrent infiltration by CD8+ T cells and CD4+ T cells is a favourable prognostic factor in non-small-cell lung carcinoma. Br J Cancer 2006, 94:275-280.
    • (2006) Br J Cancer , vol.94 , pp. 275-280
    • Hiraoka, K.1    Miyamoto, M.2    Cho, Y.3
  • 100
    • 52649163840 scopus 로고    scopus 로고
    • Prognostic effect of epithelial and stromal lymphocyte infiltration in non-small cell lung cancer
    • Al-Shibli K., Donnem T., Al-Saad S., et al. Prognostic effect of epithelial and stromal lymphocyte infiltration in non-small cell lung cancer. Clin Cancer Res 2008, 14:5220-5227.
    • (2008) Clin Cancer Res , vol.14 , pp. 5220-5227
    • Al-Shibli, K.1    Donnem, T.2    Al-Saad, S.3
  • 101
    • 77951877847 scopus 로고    scopus 로고
    • Tumor-infiltrating Foxp3+ regulatory T cells are correlated with cyclooxygenase-2 expression and are associated with recurrence in resected non-small cell lung cancer
    • Shimizu K., Nakata M., Hirami Y., et al. Tumor-infiltrating Foxp3+ regulatory T cells are correlated with cyclooxygenase-2 expression and are associated with recurrence in resected non-small cell lung cancer. J Thorac Oncol 2010, 5:585-590.
    • (2010) J Thorac Oncol , vol.5 , pp. 585-590
    • Shimizu, K.1    Nakata, M.2    Hirami, Y.3
  • 102
    • 0037314662 scopus 로고    scopus 로고
    • Up-regulation of tumor interleukin-8 expression by infiltrating macrophages: Its correlation with tumor angiogenesis and patient survival in non-small cell lung cancer
    • Chen J., Yao P., Yuan A., et al. Up-regulation of tumor interleukin-8 expression by infiltrating macrophages: Its correlation with tumor angiogenesis and patient survival in non-small cell lung cancer. Clin Cancer Res 2003, 9:729-737.
    • (2003) Clin Cancer Res , vol.9 , pp. 729-737
    • Chen, J.1    Yao, P.2    Yuan, A.3
  • 103
    • 41749104887 scopus 로고    scopus 로고
    • TREM-1 expression in tumor-associated macrophages and clinical outcome in lung cancer
    • Ho C., Liao W., Wang C., et al. TREM-1 expression in tumor-associated macrophages and clinical outcome in lung cancer. Am J Respir Crit Care Med 2008, 177:763-770.
    • (2008) Am J Respir Crit Care Med , vol.177 , pp. 763-770
    • Ho, C.1    Liao, W.2    Wang, C.3
  • 104
    • 0038121547 scopus 로고    scopus 로고
    • The role of radiotherapy in treatment of stage I non-small cell lung cancer
    • Qiao X., Tullgren O., Lax I., et al. The role of radiotherapy in treatment of stage I non-small cell lung cancer. Lung Cancer 2003, 41:1-11.
    • (2003) Lung Cancer , vol.41 , pp. 1-11
    • Qiao, X.1    Tullgren, O.2    Lax, I.3
  • 105
    • 68949092126 scopus 로고    scopus 로고
    • Lactate promotes glioma migration by TGF-beta2-dependent regulation of matrix metalloproteinase-2
    • Baumann F., Leukel P., Doerfelt A., et al. Lactate promotes glioma migration by TGF-beta2-dependent regulation of matrix metalloproteinase-2. Neuro Oncol 2009, 11:368-380.
    • (2009) Neuro Oncol , vol.11 , pp. 368-380
    • Baumann, F.1    Leukel, P.2    Doerfelt, A.3
  • 106
    • 84866732341 scopus 로고    scopus 로고
    • Radiation-induced rib fractures after hypofractionated stereotactic body radiation therapy: Risk factors and dose-volume relationship
    • Asai K., Shioyama Y., Nakamura K., et al. Radiation-induced rib fractures after hypofractionated stereotactic body radiation therapy: Risk factors and dose-volume relationship. Int J Radiat Oncol Biol Phys 2012, 84:768-773.
    • (2012) Int J Radiat Oncol Biol Phys , vol.84 , pp. 768-773
    • Asai, K.1    Shioyama, Y.2    Nakamura, K.3
  • 107
    • 67649359533 scopus 로고    scopus 로고
    • Systemic effects of local radiotherapy
    • Formenti S.C., Demaria S. Systemic effects of local radiotherapy. Lancet Oncol 2009, 10:718-726.
    • (2009) Lancet Oncol , vol.10 , pp. 718-726
    • Formenti, S.C.1    Demaria, S.2
  • 108
    • 79953054421 scopus 로고    scopus 로고
    • Strategies to improve radiotherapy with targeted drugs
    • Begg A., Stewart F., Vens C. Strategies to improve radiotherapy with targeted drugs. Nat Rev Cancer 2011, 11:239-253.
    • (2011) Nat Rev Cancer , vol.11 , pp. 239-253
    • Begg, A.1    Stewart, F.2    Vens, C.3
  • 109
    • 84866985855 scopus 로고    scopus 로고
    • Targeting the TGFβ signalling pathway in disease
    • Akhurst R., Hata A. Targeting the TGFβ signalling pathway in disease. Nat Rev Drug Discov 2012, 11:790-811.
    • (2012) Nat Rev Drug Discov , vol.11 , pp. 790-811
    • Akhurst, R.1    Hata, A.2
  • 110
    • 44449179168 scopus 로고    scopus 로고
    • Small molecular inhibitor of transforming growth factor-[beta] protects against development of radiation-induced lung injury
    • Anscher M.S., Thrasher B., Zgonjanin L., et al. Small molecular inhibitor of transforming growth factor-[beta] protects against development of radiation-induced lung injury. Int J Radiat Oncol Biol Phys 2008, 71:829-837.
    • (2008) Int J Radiat Oncol Biol Phys , vol.71 , pp. 829-837
    • Anscher, M.S.1    Thrasher, B.2    Zgonjanin, L.3


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