메뉴 건너뛰기




Volumn 3, Issue 1, 2011, Pages 19-29

Update on anti-angiogenic therapy in non-small cell lung cancer: Are we making progress?

Author keywords

Angiogenesis; Antiangiogenesis; Lung cancer; VEGF

Indexed keywords


EID: 80052444598     PISSN: 20721439     EISSN: 20776624     Source Type: Journal    
DOI: 10.3978/j.issn.2072-1439.2010.11.11     Document Type: Review
Times cited : (30)

References (72)
  • 2
    • 0345872083 scopus 로고    scopus 로고
    • Multidisciplinary management of lung cancer
    • Spira A, Ettinger DS. Multidisciplinary management of lung cancer. N Engl J Med 2004;350:379-92.
    • (2004) N Engl J Med , vol.350 , pp. 379-392
    • Spira, A.1    Ettinger, D.S.2
  • 3
    • 0022628932 scopus 로고    scopus 로고
    • A new international staging system for lung cancer
    • Mountain CF. A new international staging system for lung cancer. Chest 1986;s89:225-33.
    • Chest , vol.1986 , pp. 225-233
    • Mountain, C.F.1
  • 4
    • 0031934761 scopus 로고    scopus 로고
    • Molecular abnormalities in lung cancer
    • Salgia R, Skarin AT. Molecular abnormalities in lung cancer. J Clin Oncol 1998;16:1207-17.
    • (1998) J Clin Oncol , vol.16 , pp. 1207-1217
    • Salgia, R.1    Skarin, A.T.2
  • 5
    • 85013312416 scopus 로고
    • Tumor angiogenesis: therapeutic implications
    • Folkman J. Tumor angiogenesis: therapeutic implications. N Engl J Med 1971;285:1182-6.
    • (1971) N Engl J Med , vol.285 , pp. 1182-1186
    • Folkman, J.1
  • 6
    • 0021111648 scopus 로고
    • Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid
    • Senger DR, Galli SJ, Dvorak AM, Perruzzi CA, Harvey VS, Dvorak HF. Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid. Science 1983;219:983-5.
    • (1983) Science , vol.219 , pp. 983-985
    • Senger, D.R.1    Galli, S.J.2    Dvorak, A.M.3    Perruzzi, C.A.4    Harvey, V.S.5    Dvorak, H.F.6
  • 7
  • 8
    • 0024801035 scopus 로고
    • Vascular permeability factor, an endothelial cell mitogen related to PDGF
    • Keck PJ, Hauser SD, Krivi G, Sanzo K, Warren T, Feder J, et al. Vascular permeability factor, an endothelial cell mitogen related to PDGF. Science 1989;246:1309-12.
    • (1989) Science , vol.246 , pp. 1309-1312
    • Keck, P.J.1    Hauser, S.D.2    Krivi, G.3    Sanzo, K.4    Warren, T.5    Feder, J.6
  • 9
    • 0037699954 scopus 로고    scopus 로고
    • The biology of VEGF and its receptors
    • Ferrara N, Gerber HP, LeCouter J. The biology of VEGF and its receptors. Nat Med 2003;9:669-76.
    • (2003) Nat Med , vol.9 , pp. 669-676
    • Ferrara, N.1    Gerber, H.P.2    LeCouter, J.3
  • 10
    • 0028134936 scopus 로고
    • Placenta growth factor. Potentiation of vascular endothelial growth factor bioactivity, in vitro and in vivo, and high affinity binding to Flt-1 but not to Flk-1/KDR
    • Park JE, Chen HH, Winer J, Houck KA, Ferrara N. Placenta growth factor. Potentiation of vascular endothelial growth factor bioactivity, in vitro and in vivo, and high affinity binding to Flt-1 but not to Flk-1/KDR. J Biol Chem 1994;269:25646-54.
    • (1994) J Biol Chem , vol.269 , pp. 25646-25654
    • Park, J.E.1    Chen, H.H.2    Winer, J.3    Houck, K.A.4    Ferrara, N.5
  • 11
    • 13144266696 scopus 로고    scopus 로고
    • Vascular endothelial growth factor B (VEGF-B) binds to VEGF receptor-1 and regulates plasminogen activator activity in endothelial cells
    • Olofsson B, Korpelainen E, Pepper MS, Mandriota SJ, Aase K, Kumar V, et al. Vascular endothelial growth factor B (VEGF-B) binds to VEGF receptor-1 and regulates plasminogen activator activity in endothelial cells. Proc Natl Acad Sci U S A 1998;95:11709-14.
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 11709-11714
    • Olofsson, B.1    Korpelainen, E.2    Pepper, M.S.3    Mandriota, S.J.4    Aase, K.5    Kumar, V.6
  • 12
    • 0033846016 scopus 로고    scopus 로고
    • Vascular endothelial growth factor receptor-3 in lymphangiogenesis in wound healing
    • Paavonen K, Puolakkainen P, Jussila L, Jahkola T, Alitalo K. Vascular endothelial growth factor receptor-3 in lymphangiogenesis in wound healing. Am J Pathol 2000;156:1499-504.
    • (2000) Am J Pathol , vol.156 , pp. 1499-1504
    • Paavonen, K.1    Puolakkainen, P.2    Jussila, L.3    Jahkola, T.4    Alitalo, K.5
  • 13
    • 21144437844 scopus 로고    scopus 로고
    • Vascular endothelial cell growth factor receptor 3-mediated activation of lymphatic endothelium is crucial for tumor cell entry and spread via lymphatic vessels
    • He Y, Rajantie I, Pajusola K, Jeltsch M, Holopainen T, Yla-Herttuala S, et al. Vascular endothelial cell growth factor receptor 3-mediated activation of lymphatic endothelium is crucial for tumor cell entry and spread via lymphatic vessels. Cancer Res 2005;65:4739-46.
    • (2005) Cancer Res , vol.65 , pp. 4739-4746
    • He, Y.1    Rajantie, I.2    Pajusola, K.3    Jeltsch, M.4    Holopainen, T.5    Yla-Herttuala, S.6
  • 14
    • 4143136640 scopus 로고    scopus 로고
    • Vascular endothelial growth factor: basic science and clinical progress
    • Ferrara N. Vascular endothelial growth factor: basic science and clinical progress. Endocr Rev 2004;25:581-611.
    • (2004) Endocr Rev , vol.25 , pp. 581-611
    • Ferrara, N.1
  • 15
    • 0037362890 scopus 로고    scopus 로고
    • HIF hydroxylation and the mammalian oxygen-sensing pathway
    • Safran M, Kaelin WG Jr. HIF hydroxylation and the mammalian oxygen-sensing pathway. J Clin Invest 2003;111:779-83.
    • (2003) J Clin Invest , vol.111 , pp. 779-783
    • Safran, M.1    Kaelin Jr., W.G.2
  • 16
    • 0028816847 scopus 로고
    • Purification and characterization of hypoxia-inducible factor 1
    • Wang GL, Semenza GL. Purification and characterization of hypoxia-inducible factor 1. J Biol Chem 1995;270:1230-7.
    • (1995) J Biol Chem , vol.270 , pp. 1230-1237
    • Wang, G.L.1    Semenza, G.L.2
  • 17
    • 34748921698 scopus 로고    scopus 로고
    • Antiangiogenics: the potential role of integrating this novel treatment modality with chemoradiation for solid cancers
    • Duda DG, Jain RK, Willett CG. Antiangiogenics: the potential role of integrating this novel treatment modality with chemoradiation for solid cancers. J Clin Oncol 2007;25:4033-42.
    • (2007) J Clin Oncol , vol.25 , pp. 4033-4042
    • Duda, D.G.1    Jain, R.K.2    Willett, C.G.3
  • 18
    • 30744479430 scopus 로고    scopus 로고
    • Angiogenesis in life, disease and medicine
    • Carmeliet P. Angiogenesis in life, disease and medicine. Nature 2005;438:932-6.
    • (2005) Nature , vol.438 , pp. 932-936
    • Carmeliet, P.1
  • 19
    • 0034796595 scopus 로고    scopus 로고
    • Normalizing tumor vasculature with anti-angiogenic therapy: a new paradigm for combination therapy
    • Jain RK. Normalizing tumor vasculature with anti-angiogenic therapy: a new paradigm for combination therapy. Nat Med 2001;7:987-9.
    • (2001) Nat Med , vol.7 , pp. 987-989
    • Jain, R.K.1
  • 20
    • 11844254414 scopus 로고    scopus 로고
    • Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy
    • Jain RK. Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy. Science 2005;307:58-62.
    • (2005) Science , vol.307 , pp. 58-62
    • Jain, R.K.1
  • 21
    • 30744449235 scopus 로고    scopus 로고
    • Angiogenesis as a therapeutic target
    • Ferrara N, Kerbel RS. Angiogenesis as a therapeutic target. Nature 2005;438:967-74.
    • (2005) Nature , vol.438 , pp. 967-974
    • Ferrara, N.1    Kerbel, R.S.2
  • 22
    • 2542561964 scopus 로고    scopus 로고
    • Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer
    • Hurwitz H, Fehrenbacher L, Novotny W, Cartwright T, Hainsworth J, Heim W, et al. Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer. N Engl J Med 2004;350:2335-42.
    • (2004) N Engl J Med , vol.350 , pp. 2335-2342
    • Hurwitz, H.1    Fehrenbacher, L.2    Novotny, W.3    Cartwright, T.4    Hainsworth, J.5    Heim, W.6
  • 23
    • 46749111576 scopus 로고    scopus 로고
    • Aflibercept: AVE 0005, AVE 005, AVE0005, VEGF Trap - Regeneron, VEGF Trap (R1R2), VEGF Trap-Eye
    • Aflibercept: AVE 0005, AVE 005, AVE0005, VEGF Trap - Regeneron, VEGF Trap (R1R2), VEGF Trap-Eye. Drugs R D 2008;9:261-9.
    • (2008) Drugs R D , vol.9 , pp. 261-269
  • 24
    • 22044442973 scopus 로고    scopus 로고
    • Tyrosine kinases as targets for cancer therapy
    • Krause DS, Van Etten RA. Tyrosine kinases as targets for cancer therapy. N Engl J Med 2005;353:172-87.
    • (2005) N Engl J Med , vol.353 , pp. 172-187
    • Krause, D.S.1    Van Etten, R.A.2
  • 25
    • 2942657615 scopus 로고    scopus 로고
    • Randomized phase II trial comparing bevacizumab plus carboplatin and paclitaxel with carboplatin and paclitaxel alone in previously untreated locally advanced or metastatic non-small-cell lung cancer
    • Johnson DH, Fehrenbacher L, Novotny WF, Herbst RS, Nemunaitis JJ, Jablons DM, et al. Randomized phase II trial comparing bevacizumab plus carboplatin and paclitaxel with carboplatin and paclitaxel alone in previously untreated locally advanced or metastatic non-small-cell lung cancer. J Clin Oncol 2004;22:2184-91.
    • (2004) J Clin Oncol , vol.22 , pp. 2184-2191
    • Johnson, D.H.1    Fehrenbacher, L.2    Novotny, W.F.3    Herbst, R.S.4    Nemunaitis, J.J.5    Jablons, D.M.6
  • 26
    • 33845490014 scopus 로고    scopus 로고
    • Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer
    • Sandler A, Gray R, Perry MC, Brahmer J, Schiller JH, Dowlati A, et al. Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer. N Engl J Med 2006;355:2542-50.
    • (2006) N Engl J Med , vol.355 , pp. 2542-2550
    • Sandler, A.1    Gray, R.2    Perry, M.C.3    Brahmer, J.4    Schiller, J.H.5    Dowlati, A.6
  • 27
    • 35948980319 scopus 로고    scopus 로고
    • Outcomes for elderly advanced stage non-small cell lung cancer (NSCLC) patients (pts) treated with bevacizumab (B) in combination with carboplatin (C) and paclitaxel (P): Analysis of Eastern Cooperative Oncology Group (ECOG) 4599 study
    • (Meeting Abstracts)
    • Ramalingam SS, Dahlberg SE, Langer CJ, Gray R, Belani CP, Brahmer JR, et al. Outcomes for elderly advanced stage non-small cell lung cancer (NSCLC) patients (pts) treated with bevacizumab (B) in combination with carboplatin (C) and paclitaxel (P): Analysis of Eastern Cooperative Oncology Group (ECOG) 4599 study. J Clin Oncol (Meeting Abstracts) 2007;s25:7535.
    • (2007) J Clin Oncol , vol.s25 , pp. 7535
    • Ramalingam, S.S.1    Dahlberg, S.E.2    Langer, C.J.3    Gray, R.4    Belani, C.P.5    Brahmer, J.R.6
  • 28
    • 62449124416 scopus 로고    scopus 로고
    • Phase III trial of cisplatin plus gemcitabine with either placebo or bevacizumab as first-line therapy for nonsquamous non-small-cell lung cancer: AVAil
    • Reck M, von Pawel J, Zatloukal P, Ramlau R, Gorbounova V, Hirsh V, et al. Phase III trial of cisplatin plus gemcitabine with either placebo or bevacizumab as first-line therapy for nonsquamous non-small-cell lung cancer: AVAil. J Clin Oncol 2009;27:1227-34.
    • (2009) J Clin Oncol , vol.27 , pp. 1227-1234
    • Reck, M.1    von Pawel, J.2    Zatloukal, P.3    Ramlau, R.4    Gorbounova, V.5    Hirsh, V.6
  • 29
    • 84874971800 scopus 로고    scopus 로고
    • A Galician Lung Cancer Group phase II study of bevacizumab (B), cisplatin, and vinorelbine in chemotherapy-naive patients (p) with non-squamous non-small cell lung cancer (NSCLC)
    • (Meeting Abstracts)
    • Leon L, Vazquez S, Gracia J, Casal J, Lazaro M, Firvida JL, et al. A Galician Lung Cancer Group phase II study of bevacizumab (B), cisplatin, and vinorelbine in chemotherapy-naive patients (p) with non-squamous non-small cell lung cancer (NSCLC). J Clin Oncol (Meeting Abstracts) 2010;s28:e18052.
    • (2010) J Clin Oncol , vol.s28
    • Leon, L.1    Vazquez, S.2    Gracia, J.3    Casal, J.4    Lazaro, M.5    Firvida, J.L.6
  • 30
    • 84861973916 scopus 로고    scopus 로고
    • A phase II study of biweekly carboplatin (Cb) and gemcitabine (G) with bevacizumab (B) as first-line treatment in patients with advanced, inoperable stage IIIb/IV non-squamous non-small cell lung cancer (NSCLC)
    • (Meeting Abstracts)
    • Bommakanti S, Larson T, Dudek A, Koopmeiners J, Kumar P. A phase II study of biweekly carboplatin (Cb) and gemcitabine (G) with bevacizumab (B) as first-line treatment in patients with advanced, inoperable stage IIIb/IV non-squamous non-small cell lung cancer (NSCLC). J Clin Oncol (Meeting Abstracts) 2010;s28:e18091.
    • (2010) J Clin Oncol , vol.s28
    • Bommakanti, S.1    Larson, T.2    Dudek, A.3    Koopmeiners, J.4    Kumar, P.5
  • 31
    • 36148992949 scopus 로고    scopus 로고
    • The role of bevacizumab in the treatment of non-small cell lung cancer: current indications and future developments
    • Gridelli C, Maione P, Rossi A, De Marinis F. The role of bevacizumab in the treatment of non-small cell lung cancer: current indications and future developments. Oncologist 2007;12:1183-93.
    • (2007) Oncologist , vol.12 , pp. 1183-1193
    • Gridelli, C.1    Maione, P.2    Rossi, A.3    De Marinis, F.4
  • 32
    • 77955268612 scopus 로고    scopus 로고
    • Safety and efficacy of first-line bevacizumab-based therapy in advanced non-squamous non-small-cell lung cancer (SAiL MO19390): a phase 4 study
    • Crino L, Dansin E, Garrido P, Griesinger F, Laskin J, Pavlakis N, et al. Safety and efficacy of first-line bevacizumab-based therapy in advanced non-squamous non-small-cell lung cancer (SAiL, MO19390): a phase 4 study. Lancet Oncol 2010;11:733-40.
    • (2010) Lancet Oncol , vol.11 , pp. 733-740
    • Crino, L.1    Dansin, E.2    Garrido, P.3    Griesinger, F.4    Laskin, J.5    Pavlakis, N.6
  • 33
    • 84861962697 scopus 로고    scopus 로고
    • BRIDGE: An open-label phase II trial evaluating the safety of bevacizumab (BV) plus paclitaxel/carboplatin (PC) as first-line treatment (tx) for patients (pts) with advanced, previously untreated, squamous non-small cell lung cancer (NSCLC)
    • (Meeting Abstracts)
    • Faoro L, Hainsworth JD, Karlin DA, Huang JE, Fang L, Scappaticci FA. BRIDGE: An open-label phase II trial evaluating the safety of bevacizumab (BV) plus paclitaxel/carboplatin (PC) as first-line treatment (tx) for patients (pts) with advanced, previously untreated, squamous non-small cell lung cancer (NSCLC). J Clin Oncol (Meeting Abstracts) 2010;s28:7583.
    • (2010) J Clin Oncol , vol.s28 , pp. 7583
    • Faoro, L.1    Hainsworth, J.D.2    Karlin, D.A.3    Huang, J.E.4    Fang, L.5    Scappaticci, F.A.6
  • 34
    • 70449725036 scopus 로고    scopus 로고
    • Safety of bevacizumab in patients with non-small-cell lung cancer and brain metastases
    • Socinski MA, Langer CJ, Huang JE, Kolb MM, Compton P, Wang L, et al. Safety of bevacizumab in patients with non-small-cell lung cancer and brain metastases. J Clin Oncol 2009;27:5255-61.
    • (2009) J Clin Oncol , vol.27 , pp. 5255-5261
    • Socinski, M.A.1    Langer, C.J.2    Huang, J.E.3    Kolb, M.M.4    Compton, P.5    Wang, L.6
  • 35
    • 77954428008 scopus 로고    scopus 로고
    • A multicenter, phase 2 study of vascular endothelial growth factor trap (Aflibercept) in platinum- and erlotinib-resistant adenocarcinoma of the lung
    • Leighl NB, Raez LE, Besse B, Rosen PJ, Barlesi F, Massarelli E, et al. A multicenter, phase 2 study of vascular endothelial growth factor trap (Aflibercept) in platinum- and erlotinib-resistant adenocarcinoma of the lung. J Thorac Oncol 2010;5:1054-9.
    • (2010) J Thorac Oncol , vol.5 , pp. 1054-1059
    • Leighl, N.B.1    Raez, L.E.2    Besse, B.3    Rosen, P.J.4    Barlesi, F.5    Massarelli, E.6
  • 36
    • 79955549964 scopus 로고    scopus 로고
    • A phase II, open-label study of ramucirumab (IMC-1121B), an IgG1 fully human monoclonal antibody (MAb) targeting VEGFR-2, in combination with paclitaxel and carboplatin as first-line therapy in patients (pts) with stage IIIb/IV non-small cell lung cancer (NSCLC)
    • (Meeting Abstracts)
    • Camidge DR, Ballas MS, Dubey S, Haigentz M, Rosen PJ, Spicer JF, et al. A phase II, open-label study of ramucirumab (IMC-1121B), an IgG1 fully human monoclonal antibody (MAb) targeting VEGFR-2, in combination with paclitaxel and carboplatin as first-line therapy in patients (pts) with stage IIIb/IV non-small cell lung cancer (NSCLC). J Clin Oncol (Meeting Abstracts) 2010;s28:7588.
    • (2010) J Clin Oncol , vol.s28 , pp. 7588
    • Camidge, D.R.1    Ballas, M.S.2    Dubey, S.3    Haigentz, M.4    Rosen, P.J.5    Spicer, J.F.6
  • 37
    • 84875001329 scopus 로고    scopus 로고
    • Randomized phase II study of human anti-platelet-derived growth factor receptor alpha (PDGFR{alpha}) monoclonal antibody (IMC-3G3) with paclitaxel/carboplatin (P/C) or P/C alone in first-line treatment of stage IIIb/IV non-small cell lung cancer (NSCLC)
    • (Meeting Abstracts)
    • Gerber DE, Brekken RA, Hoang T, Youssoufian H, Rowinsky EK, Loizos N, et al. Randomized phase II study of human anti-platelet-derived growth factor receptor alpha (PDGFR{alpha}) monoclonal antibody (IMC-3G3) with paclitaxel/carboplatin (P/C) or P/C alone in first-line treatment of stage IIIb/IV non-small cell lung cancer (NSCLC). J Clin Oncol (Meeting Abstracts) 2010;s28:TPS296
    • (2010) J Clin Oncol , vol.s28
    • Gerber, D.E.1    Brekken, R.A.2    Hoang, T.3    Youssoufian, H.4    Rowinsky, E.K.5    Loizos, N.6
  • 38
    • 5044236157 scopus 로고    scopus 로고
    • Epidermal growth factor receptor in tumor angiogenesis
    • Ellis LM. Epidermal growth factor receptor in tumor angiogenesis. Hematol Oncol Clin North Am 2004;18:1007-21.
    • (2004) Hematol Oncol Clin North Am , vol.18 , pp. 1007-1021
    • Ellis, L.M.1
  • 39
    • 2342471392 scopus 로고    scopus 로고
    • Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib
    • Lynch TJ, Bell DW, Sordella R, Gurubhagavatula S, Okimoto RA, Brannigan BW, et al. Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. N Engl J Med 2004;350:2129-39.
    • (2004) N Engl J Med , vol.350 , pp. 2129-2139
    • Lynch, T.J.1    Bell, D.W.2    Sordella, R.3    Gurubhagavatula, S.4    Okimoto, R.A.5    Brannigan, B.W.6
  • 40
    • 20244381389 scopus 로고    scopus 로고
    • Phase I/II trial evaluating the anti-vascular endothelial growth factor monoclonal antibody bevacizumab in combination with the HER-1/epidermal growth factor receptor tyrosine kinase inhibitor erlotinib for patients with recurrent non-small-cell lung cancer
    • Herbst RS, Johnson DH, Mininberg E, Carbone DP, Henderson T, Kim ES, et al. Phase I/II trial evaluating the anti-vascular endothelial growth factor monoclonal antibody bevacizumab in combination with the HER-1/epidermal growth factor receptor tyrosine kinase inhibitor erlotinib for patients with recurrent non-small-cell lung cancer. J Clin Oncol 2005;23:2544-55.
    • (2005) J Clin Oncol , vol.23 , pp. 2544-2555
    • Herbst, R.S.1    Johnson, D.H.2    Mininberg, E.3    Carbone, D.P.4    Henderson, T.5    Kim, E.S.6
  • 41
    • 36048982143 scopus 로고    scopus 로고
    • Phase II study of efficacy and safety of bevacizumab in combination with chemotherapy or erlotinib compared with chemotherapy alone for treatment of recurrent or refractory non small-cell lung cancer
    • Herbst RS, O'Neill VJ, Fehrenbacher L, Belani CP, Bonomi PD, Hart L, et al. Phase II study of efficacy and safety of bevacizumab in combination with chemotherapy or erlotinib compared with chemotherapy alone for treatment of recurrent or refractory non small-cell lung cancer. J Clin Oncol 2007;25:4743-50.
    • (2007) J Clin Oncol , vol.25 , pp. 4743-4750
    • Herbst, R.S.1    O'Neill, V.J.2    Fehrenbacher, L.3    Belani, C.P.4    Bonomi, P.D.5    Hart, L.6
  • 42
    • 78449274913 scopus 로고    scopus 로고
    • ATLAS Investigators. Overall survival (OS) in ATLAS, a phase IIIb trial comparing bevacizumab (B) therapy with or without erlotinib (E) after completion of chemotherapy (chemo) with B for first-line treatment of locally advanced, recurrent, or metastatic non-small cell lung cancer (NSCLC)
    • (Meeting Abstracts)
    • Kabbinavar FF, Miller VA, Johnson BE, O'Connor PG, Soh C, ATLAS Investigators. Overall survival (OS) in ATLAS, a phase IIIb trial comparing bevacizumab (B) therapy with or without erlotinib (E) after completion of chemotherapy (chemo) with B for first-line treatment of locally advanced, recurrent, or metastatic non-small cell lung cancer (NSCLC). J Clin Oncol (Meeting Abstracts) 2010;s28:7526.
    • (2010) J Clin Oncol , vol.s28 , pp. 7526
    • Kabbinavar, F.F.1    Miller, V.A.2    Johnson, B.E.3    O'Connor, P.G.4    Soh, C.5
  • 43
    • 59849105332 scopus 로고    scopus 로고
    • Avastin-Tarceva combination fails in lung cancer
    • Jones D. Avastin-Tarceva combination fails in lung cancer. Nat Biotechnol 2009;27:108-9.
    • (2009) Nat Biotechnol , vol.27 , pp. 108-109
    • Jones, D.1
  • 44
    • 33746591262 scopus 로고    scopus 로고
    • Tyrosine kinase inhibitors of vascular endothelial growth factor receptors in clinical trials: current status and future directions
    • Morabito A, De Maio E, Di Maio M, Normanno N, Perrone F. Tyrosine kinase inhibitors of vascular endothelial growth factor receptors in clinical trials: current status and future directions. Oncologist 2006;11:753-64.
    • (2006) Oncologist , vol.11 , pp. 753-764
    • Morabito, A.1    De Maio, E.2    Di Maio, M.3    Normanno, N.4    Perrone, F.5
  • 45
    • 44849140532 scopus 로고    scopus 로고
    • Dual targeting of the vascular endothelial growth factor receptor and epidermal growth factor receptor pathways with vandetinib (ZD6474) in patients with advanced or metastatic non-small cell lung cancer
    • Natale RB. Dual targeting of the vascular endothelial growth factor receptor and epidermal growth factor receptor pathways with vandetinib (ZD6474) in patients with advanced or metastatic non-small cell lung cancer. J Thorac Oncol 2008;s3:128-30.
    • (2008) J Thorac Oncol , vol.s3 , pp. 128-130
    • Natale, R.B.1
  • 46
    • 66349087009 scopus 로고    scopus 로고
    • Vandetanib versus gefitinib in patients with advanced non-small-cell lung cancer: results from a two-part, double-blind, randomized phase ii study
    • Natale RB, Bodkin D, Govindan R, Sleckman BG, Rizvi NA, Capo A, et al. Vandetanib versus gefitinib in patients with advanced non-small-cell lung cancer: results from a two-part, double-blind, randomized phase ii study. J Clin Oncol 2009;27:2523-9.
    • (2009) J Clin Oncol , vol.27 , pp. 2523-2529
    • Natale, R.B.1    Bodkin, D.2    Govindan, R.3    Sleckman, B.G.4    Rizvi, N.A.5    Capo, A.6
  • 47
    • 34948838898 scopus 로고    scopus 로고
    • Randomized, placebo-controlled phase II study of vandetanib plus docetaxel in previously treated non small-cell lung cancer
    • Heymach JV, Johnson BE, Prager D, Csada E, Roubec J, Pesek M, et al. Randomized, placebo-controlled phase II study of vandetanib plus docetaxel in previously treated non small-cell lung cancer. J Clin Oncol 2007;25:4270-7.
    • (2007) J Clin Oncol , vol.25 , pp. 4270-4277
    • Heymach, J.V.1    Johnson, B.E.2    Prager, D.3    Csada, E.4    Roubec, J.5    Pesek, M.6
  • 48
    • 77954035012 scopus 로고    scopus 로고
    • Vandetanib plus docetaxel versus docetaxel as second-line treatment for patients with advanced non-small-cell lung cancer (ZODIAC): a double-blind, randomised, phase 3 trial
    • Herbst, RS, Sun Y, Eberhardt WE, Germonpre P, Saijo N, Zhou C, et al. Vandetanib plus docetaxel versus docetaxel as second-line treatment for patients with advanced non-small-cell lung cancer (ZODIAC): a double-blind, randomised, phase 3 trial. Lancet Oncol 2010;11:619-26.
    • (2010) Lancet Oncol , vol.11 , pp. 619-626
    • Herbst, R.S.1    Sun, Y.2    Eberhardt, W.E.3    Germonpre, P.4    Saijo, N.5    Zhou, C.6
  • 49
    • 79959371861 scopus 로고    scopus 로고
    • Tumor biomarker analyses from the phase III ZODIAC study of docetaxel (D) plus or minus vandetanib (VAN) in second-line advanced NSCLC
    • (Meeting Abstracts)
    • Johnson BE, Ryan AJ, Heymach J, Stephens C, Kennedy SJ, Langmuir PB, et al. Tumor biomarker analyses from the phase III ZODIAC study of docetaxel (D) plus or minus vandetanib (VAN) in second-line advanced NSCLC. J Clin Oncol (Meeting Abstracts) 2010;s28:7516.
    • (2010) J Clin Oncol , vol.s28 , pp. 7516
    • Johnson, B.E.1    Ryan, A.J.2    Heymach, J.3    Stephens, C.4    Kennedy, S.J.5    Langmuir, P.B.6
  • 50
    • 78049395323 scopus 로고    scopus 로고
    • Vandetanib versus placebo in patients with advanced non-small cell lung cancer (NSCLC) after prior therapy with an EGFR tyrosine kinase inhibitor (TKI): A randomized, double-blind phase III trial (ZEPHYR)
    • (Meeting Abstracts)
    • Lee J, Hirsh V, Park K, Qin S, Blajman CR, Perng R, et al. Vandetanib versus placebo in patients with advanced non-small cell lung cancer (NSCLC) after prior therapy with an EGFR tyrosine kinase inhibitor (TKI): A randomized, double-blind phase III trial (ZEPHYR). J Clin Oncol (Meeting Abstracts) 2010;s28:7525.
    • (2010) J Clin Oncol , vol.s28 , pp. 7525
    • Lee, J.1    Hirsh, V.2    Park, K.3    Qin, S.4    Blajman, C.R.5    Perng, R.6
  • 51
    • 66249118670 scopus 로고    scopus 로고
    • Vandetanib (ZD6474), a dual inhibitor of vascular endothelial growth factor receptor (VEGFR) and epidermal growth factor receptor (EGFR) tyrosine kinases: current status and future directions
    • Morabito A, Piccirillo MC, Falasconi F, De Feo G, Del Giudice A, Bryce J, et al. Vandetanib (ZD6474), a dual inhibitor of vascular endothelial growth factor receptor (VEGFR) and epidermal growth factor receptor (EGFR) tyrosine kinases: current status and future directions. Oncologist 2009;14:378-90.
    • (2009) Oncologist , vol.14 , pp. 378-390
    • Morabito, A.1    Piccirillo, M.C.2    Falasconi, F.3    De Feo, G.4    Del Giudice, A.5    Bryce, J.6
  • 53
    • 77952666762 scopus 로고    scopus 로고
    • Targeting angiogenesis with multitargeted tyrosine kinase inhibitors in the treatment of non-small cell lung cancer
    • Scagliotti G, Govindan R. Targeting angiogenesis with multitargeted tyrosine kinase inhibitors in the treatment of non-small cell lung cancer. Oncologist 2010;15:436-46.
    • (2010) Oncologist , vol.15 , pp. 436-446
    • Scagliotti, G.1    Govindan, R.2
  • 54
    • 65349161533 scopus 로고    scopus 로고
    • A randomized discontinuation phase II study of sorafenib versus placebo in patients with non-small cell lung cancer who have failed at least two prior chemotherapy regimens: E2501
    • (Meeting Abstracts)
    • Schiller JH, Lee JW, Hanna NH, Traynor AM, Carbone DP. A randomized discontinuation phase II study of sorafenib versus placebo in patients with non-small cell lung cancer who have failed at least two prior chemotherapy regimens: E2501. J Clin Oncol (Meeting Abstracts) 2008;s26:8014.
    • (2008) J Clin Oncol , vol.s26 , pp. 8014
    • Schiller, J.H.1    Lee, J.W.2    Hanna, N.H.3    Traynor, A.M.4    Carbone, D.P.5
  • 55
    • 79952261009 scopus 로고    scopus 로고
    • Use of germline polymorphisms in VEGF to predict tumor response and progression-free survival in non-small cell lung cancer (NSCLC) patients treated with sorafenib: Subset pharmacogenetic analysis of Eastern Cooperative Oncology Group (ECOG) trial E2501
    • (Meeting Abstracts)
    • Zhang W, Lee J, Schiller JH, Carbone DP, Chung CH, Lenz H. Use of germline polymorphisms in VEGF to predict tumor response and progression-free survival in non-small cell lung cancer (NSCLC) patients treated with sorafenib: Subset pharmacogenetic analysis of Eastern Cooperative Oncology Group (ECOG) trial E2501. J Clin Oncol (Meeting Abstracts) 2010;s28:7607.
    • (2010) J Clin Oncol , vol.s28 , pp. 7607
    • Zhang, W.1    Lee, J.2    Schiller, J.H.3    Carbone, D.P.4    Chung, C.H.5    Lenz, H.6
  • 56
    • 78049411804 scopus 로고    scopus 로고
    • A randomized phase II study of gemcitabine (G) and carboplatin (C) with or without cediranib (AZD2171 [CED]) as first-line therapy in advanced non-small cell lung cancer (NSCLC)
    • (Meeting Abstracts)
    • Dy GK, Mandrekar SJ, Nelson GD, Ross HJ, Ansari RH, Lyss AP, et al. A randomized phase II study of gemcitabine (G) and carboplatin (C) with or without cediranib (AZD2171 [CED]) as first-line therapy in advanced non-small cell lung cancer (NSCLC). J Clin Oncol (Meeting Abstracts) 2010;s28:7603.
    • (2010) J Clin Oncol , vol.s28 , pp. 7603
    • Dy, G.K.1    Mandrekar, S.J.2    Nelson, G.D.3    Ross, H.J.4    Ansari, R.H.5    Lyss, A.P.6
  • 57
    • 44649167010 scopus 로고    scopus 로고
    • Second-generation epidermal growth factor receptor tyrosine kinase inhibitors in non-small cell lung cancer
    • Riely GJ. Second-generation epidermal growth factor receptor tyrosine kinase inhibitors in non-small cell lung cancer. J Thorac Oncol 2008;s3:146-9.
    • (2008) J Thorac Oncol , vol.s3 , pp. 146-149
    • Riely, G.1
  • 58
    • 78049392715 scopus 로고    scopus 로고
    • Randomized, open-label phase II study of motesanib or bevacizumab in combination with paclitaxel and carboplatin (P/C) for advanced nonsquamous non-small cell lung cancer (NSCLC)
    • (Meeting Abstracts)
    • Blumenschein GR, Kabbinavar FF, Menon H, Mok T, Stephenson J, Beck JT, et al. Randomized, open-label phase II study of motesanib or bevacizumab in combination with paclitaxel and carboplatin (P/C) for advanced nonsquamous non-small cell lung cancer (NSCLC). J Clin Oncol (Meeting Abstracts) 2010;s28:7528.
    • (2010) J Clin Oncol , vol.s28 , pp. 7528
    • Blumenschein, G.R.1    Kabbinavar, F.F.2    Menon, H.3    Mok, T.4    Stephenson, J.5    Beck, J.T.6
  • 60
    • 2642571660 scopus 로고    scopus 로고
    • Vascular-targeting therapies for treatment of malignant disease
    • Siemann DW, Chaplin DJ, Horsman MR. Vascular-targeting therapies for treatment of malignant disease. Cancer 2004;100:2491-9.
    • (2004) Cancer , vol.100 , pp. 2491-2499
    • Siemann, D.W.1    Chaplin, D.J.2    Horsman, M.R.3
  • 61
    • 77956311177 scopus 로고    scopus 로고
    • Randomized phase II trial of a tumor vascular disrupting agent fosbretabulin tromethamine (CA4P) with carboplatin (C), paclitaxel (P), and bevacizumab (B) in stage IIIb/IV nonsquamous non-small cell lung cancer (NSCLC): The FALCON trial
    • (Meeting Abstracts)
    • Garon EB, Kabbinavar FF, Neidhart JA, Neidhart JD, Gabrail NY, Oliveira MR, et al. Randomized phase II trial of a tumor vascular disrupting agent fosbretabulin tromethamine (CA4P) with carboplatin (C), paclitaxel (P), and bevacizumab (B) in stage IIIb/IV nonsquamous non-small cell lung cancer (NSCLC): The FALCON trial. J Clin Oncol (Meeting Abstracts) 2010;s28:7587.
    • (2010) J Clin Oncol , vol.s28 , pp. 7587
    • Garon, E.B.1    Kabbinavar, F.F.2    Neidhart, J.A.3    Neidhart, J.D.4    Gabrail, N.Y.5    Oliveira, M.R.6
  • 62
    • 78049454954 scopus 로고    scopus 로고
    • Phase II study of docetaxel with or without plinabulin (NPI-2358) in patients with non-small cell lung cancer (NSCLC)
    • (Meeting Abstracts)
    • Mita AC, Heist RS, Aren O, Mainwaring PN, Bazhenova L, Gadgeel SM, et al. Phase II study of docetaxel with or without plinabulin (NPI-2358) in patients with non-small cell lung cancer (NSCLC). J Clin Oncol (Meeting Abstracts) 2010;s28:7592.
    • (2010) J Clin Oncol , vol.s28 , pp. 7592
    • Mita, A.C.1    Heist, R.S.2    Aren, O.3    Mainwaring, P.N.4    Bazhenova, L.5    Gadgeel, S.M.6
  • 63
    • 68049108414 scopus 로고    scopus 로고
    • Vascular disrupting agents: a novel mechanism of action in the battle against non-small cell lung cancer
    • Gridelli C, Rossi A, Maione P, Rossi E, Castaldo V, Sacco PC, et al. Vascular disrupting agents: a novel mechanism of action in the battle against non-small cell lung cancer. Oncologist 2009;14:612-20.
    • (2009) Oncologist , vol.14 , pp. 612-620
    • Gridelli, C.1    Rossi, A.2    Maione, P.3    Rossi, E.4    Castaldo, V.5    Sacco, P.C.6
  • 64
    • 0037050355 scopus 로고    scopus 로고
    • Lung cancer-time to move on from chemotherapy
    • Carney DN. Lung cancer-time to move on from chemotherapy. N Engl J Med 2002;346:126-8.
    • (2002) N Engl J Med , vol.346 , pp. 126-128
    • Carney, D.N.1
  • 65
    • 34547346812 scopus 로고    scopus 로고
    • Challenges of antiangiogenic cancer therapy: trials and errors, and renewed hope
    • Medina MA, Munoz-Chapuli R, Quesada AR. Challenges of antiangiogenic cancer therapy: trials and errors, and renewed hope. J Cell Mol Med 2007;11:374-82.
    • (2007) J Cell Mol Med , vol.11 , pp. 374-382
    • Medina, M.A.1    Munoz-Chapuli, R.2    Quesada, A.R.3
  • 66
    • 49049089802 scopus 로고    scopus 로고
    • Phase III study comparing cisplatin plus gemcitabine with cisplatin plus pemetrexed in chemotherapy-naive patients with advanced-stage non-small-cell lung cancer
    • Scagliotti GV, Parikh P, von Pawel J, Biesma B, Vansteenkiste J, Manegold C, et al. Phase III study comparing cisplatin plus gemcitabine with cisplatin plus pemetrexed in chemotherapy-naive patients with advanced-stage non-small-cell lung cancer. J Clin Oncol 2008;26:3543-51.
    • (2008) J Clin Oncol , vol.26 , pp. 3543-3551
    • Scagliotti, G.V.1    Parikh, P.2    von Pawel, J.3    Biesma, B.4    Vansteenkiste, J.5    Manegold, C.6
  • 68
    • 77955174967 scopus 로고    scopus 로고
    • Clinical activity of the oral ALK inhibitor PF-02341066 in ALK-positive patients with non-small cell lung cancer (NSCLC)
    • (Meeting Abstracts)
    • Bang Y, Kwak EL, Shaw AT, Camidge DR, Iafrate AJ, Maki RG, et al. Clinical activity of the oral ALK inhibitor PF-02341066 in ALK-positive patients with non-small cell lung cancer (NSCLC). J Clin Oncol (Meeting Abstracts) 2010;s28:3.
    • (2010) J Clin Oncol , vol.s28 , pp. 3
    • Bang, Y.1    Kwak, E.L.2    Shaw, A.T.3    Camidge, D.R.4    Iafrate, A.J.5    Maki, R.G.6
  • 69
    • 0037096812 scopus 로고    scopus 로고
    • Novel targets for lung cancer therapy: part I
    • Dy GK, Adjei AA. Novel targets for lung cancer therapy: part I. J Clin Oncol 2002;20:2881-94.
    • (2002) J Clin Oncol , vol.20 , pp. 2881-2894
    • Dy, G.K.1    Adjei, A.A.2
  • 71
    • 61649116935 scopus 로고    scopus 로고
    • An open-label study of vandetanib with pemetrexed in patients with previously treated non-small-cell lung cancer
    • de Boer R, Humblet Y, Wolf J, Nogova L, Ruffert K, Milenkova T, et al. An open-label study of vandetanib with pemetrexed in patients with previously treated non-small-cell lung cancer. Ann Oncol 2009;20:486-91.
    • (2009) Ann Oncol , vol.20 , pp. 486-491
    • de Boer, R.1    Humblet, Y.2    Wolf, J.3    Nogova, L.4    Ruffert, K.5    Milenkova, T.6
  • 72
    • 70349476412 scopus 로고    scopus 로고
    • Vandetanib versus erlotinib in patients with advanced non-small cell lung cancer (NSCLC) after failure of at least one prior cytotoxic chemotherapy: A randomized, double-blind phase III trial (ZEST)
    • (Meeting Abstracts)
    • Natale RB, Thongprasert S, Greco FA, Thomas M, Tsai CM, Sunpaweravong P, et al. Vandetanib versus erlotinib in patients with advanced non-small cell lung cancer (NSCLC) after failure of at least one prior cytotoxic chemotherapy: A randomized, double-blind phase III trial (ZEST). J Clin Oncol (Meeting Abstracts) 2009;s27:8009.
    • (2009) J Clin Oncol , vol.s27 , pp. 8009
    • Natale, R.B.1    Thongprasert, S.2    Greco, F.A.3    Thomas, M.4    Tsai, C.M.5    Sunpaweravong, P.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.