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Volumn 228, Issue 8, 2013, Pages 1651-1657

Carcinoma-associated fibroblasts: Non-neoplastic tumour-promoting mesenchymal cells

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; FIBROBLAST GROWTH FACTOR 2; FIBROBLAST GROWTH FACTOR RECEPTOR 1; FRIZZLED PROTEIN; INTERLEUKIN 11; MICRORNA 16; MICRORNA 214; MICRORNA 31; RANTES; STAT3 PROTEIN; STROMAL CELL DERIVED FACTOR 1; VASCULOTROPIN;

EID: 84876721085     PISSN: 00219541     EISSN: 10974652     Source Type: Journal    
DOI: 10.1002/jcp.24347     Document Type: Short Survey
Times cited : (189)

References (105)
  • 1
    • 84866985855 scopus 로고    scopus 로고
    • Targeting the TGFbeta signalling pathway in disease
    • Akhurst RJ, Hata A. 2012. Targeting the TGFbeta signalling pathway in disease. Nature Rev 11:790-811.
    • (2012) Nature Rev , vol.11 , pp. 790-811
    • Akhurst, R.J.1    Hata, A.2
  • 4
    • 84856092772 scopus 로고    scopus 로고
    • Arousal of cancer-associated stroma: Overexpression of palladin activates fibroblasts to promote tumor invasion
    • Brentnall TA, Lai LA, Coleman J, Bronner MP, Pan S, Chen R. 2012. Arousal of cancer-associated stroma: Overexpression of palladin activates fibroblasts to promote tumor invasion. PLoS ONE 7:e30219.
    • (2012) PLoS ONE , vol.7
    • Brentnall, T.A.1    Lai, L.A.2    Coleman, J.3    Bronner, M.P.4    Pan, S.5    Chen, R.6
  • 7
    • 70149088171 scopus 로고    scopus 로고
    • Clonal mutations in the cancer-associated fibroblasts: The case against genetic coevolution
    • discussion 6769.
    • Campbell I, Polyak K, Haviv I. 2009. Clonal mutations in the cancer-associated fibroblasts: The case against genetic coevolution. Cancer Res 69:6765-6768, discussion 6769.
    • (2009) Cancer Res , vol.69 , pp. 6765-6768
    • Campbell, I.1    Polyak, K.2    Haviv, I.3
  • 8
    • 79953147370 scopus 로고    scopus 로고
    • A perspective on cancer cell metastasis
    • Chaffer CL, Weinberg RA. 2011. A perspective on cancer cell metastasis. Science 331:1559-1564.
    • (2011) Science , vol.331 , pp. 1559-1564
    • Chaffer, C.L.1    Weinberg, R.A.2
  • 9
    • 34250321214 scopus 로고    scopus 로고
    • Enhanced hepatocyte growth factor signaling by type II transforming growth factor-beta receptor knockout fibroblasts promotes mammary tumorigenesis
    • Cheng N, Chytil A, Shyr Y, Joly A, Moses HL. 2007. Enhanced hepatocyte growth factor signaling by type II transforming growth factor-beta receptor knockout fibroblasts promotes mammary tumorigenesis. Cancer Res 67:4869-4877.
    • (2007) Cancer Res , vol.67 , pp. 4869-4877
    • Cheng, N.1    Chytil, A.2    Shyr, Y.3    Joly, A.4    Moses, H.L.5
  • 10
    • 57849106330 scopus 로고    scopus 로고
    • PDGF-C mediates the angiogenic and tumorigenic properties of fibroblasts associated with tumors refractory to anti-VEGF treatment
    • Crawford Y, Kasman I, Yu L, Zhong C, Wu X, Modrusan Z, Kaminker J, Ferrara N. 2009. PDGF-C mediates the angiogenic and tumorigenic properties of fibroblasts associated with tumors refractory to anti-VEGF treatment. Cancer Cell 15:21-34.
    • (2009) Cancer Cell , vol.15 , pp. 21-34
    • Crawford, Y.1    Kasman, I.2    Yu, L.3    Zhong, C.4    Wu, X.5    Modrusan, Z.6    Kaminker, J.7    Ferrara, N.8
  • 11
    • 5444248307 scopus 로고    scopus 로고
    • Tenascin-C and SF/HGF produced by myofibroblasts in vitro provide convergent pro-invasive signals to human colon cancer cells through RhoA and Rac
    • De Wever O, Nguyen QD, Van Hoorde L, Bracke M, Bruyneel E, Gespach C, Mareel M. 2004. Tenascin-C and SF/HGF produced by myofibroblasts in vitro provide convergent pro-invasive signals to human colon cancer cells through RhoA and Rac. FASEB J 18:1016-1018.
    • (2004) FASEB J , vol.18 , pp. 1016-1018
    • De Wever, O.1    Nguyen, Q.D.2    Van Hoorde, L.3    Bracke, M.4    Bruyneel, E.5    Gespach, C.6    Mareel, M.7
  • 12
    • 5444261094 scopus 로고    scopus 로고
    • The stroma reaction myofibroblast: A key player in the control of tumor cell behavior
    • Desmouliere A, Guyot C, Gabbiani G. 2004. The stroma reaction myofibroblast: A key player in the control of tumor cell behavior. Int J Dev Biol 48:509-517.
    • (2004) Int J Dev Biol , vol.48 , pp. 509-517
    • Desmouliere, A.1    Guyot, C.2    Gabbiani, G.3
  • 14
    • 27944497333 scopus 로고    scopus 로고
    • Tissue cells feel and respond to the stiffness of their substrate
    • Discher DE, Janmey P, Wang YL. 2005. Tissue cells feel and respond to the stiffness of their substrate. Science 310:1139-1143.
    • (2005) Science , vol.310 , pp. 1139-1143
    • Discher, D.E.1    Janmey, P.2    Wang, Y.L.3
  • 17
    • 67651166789 scopus 로고    scopus 로고
    • CXCR4 and matrix metalloproteinase-1 are elevated in breast carcinoma-associated fibroblasts and in normal mammary fibroblasts exposed to factors secreted by breast cancer cells
    • Eck SM, Cote AL, Winkelman WD, Brinckerhoff CE. 2009. CXCR4 and matrix metalloproteinase-1 are elevated in breast carcinoma-associated fibroblasts and in normal mammary fibroblasts exposed to factors secreted by breast cancer cells. Mol Cancer Res 7:1033-1044.
    • (2009) Mol Cancer Res , vol.7 , pp. 1033-1044
    • Eck, S.M.1    Cote, A.L.2    Winkelman, W.D.3    Brinckerhoff, C.E.4
  • 18
    • 76349096670 scopus 로고    scopus 로고
    • Cancer-associated fibroblasts are activated in incipient neoplasia to orchestrate tumor-promoting inflammation in an NF-kappaB-dependent manner
    • Erez N, Truitt M, Olson P, Arron ST, Hanahan D. 2010. Cancer-associated fibroblasts are activated in incipient neoplasia to orchestrate tumor-promoting inflammation in an NF-kappaB-dependent manner. Cancer Cell 17:135-147.
    • (2010) Cancer Cell , vol.17 , pp. 135-147
    • Erez, N.1    Truitt, M.2    Olson, P.3    Arron, S.T.4    Hanahan, D.5
  • 19
    • 36749013537 scopus 로고    scopus 로고
    • Fibroblast-led collective invasion of carcinoma cells with differing roles for RhoGTPases in leading and following cells
    • Gaggioli C, Hooper S, Hidalgo-Carcedo C, Grosse R, Marshall JF, Harrington K, Sahai E. 2007. Fibroblast-led collective invasion of carcinoma cells with differing roles for RhoGTPases in leading and following cells. Nat Cell Biol 9:1392-1400.
    • (2007) Nat Cell Biol , vol.9 , pp. 1392-1400
    • Gaggioli, C.1    Hooper, S.2    Hidalgo-Carcedo, C.3    Grosse, R.4    Marshall, J.F.5    Harrington, K.6    Sahai, E.7
  • 20
    • 79251478398 scopus 로고    scopus 로고
    • Contribution of platelets to tumour metastasis
    • Gay LJ, Felding-Habermann B. 2011. Contribution of platelets to tumour metastasis. Nat Rev Cancer 11:123-134.
    • (2011) Nat Rev Cancer , vol.11 , pp. 123-134
    • Gay, L.J.1    Felding-Habermann, B.2
  • 21
    • 70449526719 scopus 로고    scopus 로고
    • Localized and reversible TGFbeta signalling switches breast cancer cells from cohesive to single cell motility
    • Giampieri S, Manning C, Hooper S, Jones L, Hill CS, Sahai E. 2009. Localized and reversible TGFbeta signalling switches breast cancer cells from cohesive to single cell motility. Nat Cell Biol 11:1287-1296.
    • (2009) Nat Cell Biol , vol.11 , pp. 1287-1296
    • Giampieri, S.1    Manning, C.2    Hooper, S.3    Jones, L.4    Hill, C.S.5    Sahai, E.6
  • 22
    • 77956280130 scopus 로고    scopus 로고
    • Reciprocal activation of prostate cancer cells and cancer-associated fibroblasts stimulates epithelial-mesenchymal transition and cancer stemness
    • Giannoni E, Bianchini F, Masieri L, Serni S, Torre E, Calorini L, Chiarugi P. 2010. Reciprocal activation of prostate cancer cells and cancer-associated fibroblasts stimulates epithelial-mesenchymal transition and cancer stemness. Cancer Res 70:6945-6956.
    • (2010) Cancer Res , vol.70 , pp. 6945-6956
    • Giannoni, E.1    Bianchini, F.2    Masieri, L.3    Serni, S.4    Torre, E.5    Calorini, L.6    Chiarugi, P.7
  • 23
    • 79957532451 scopus 로고    scopus 로고
    • Cancer associated fibroblasts exploit reactive oxygen species through a proinflammatory signature leading to epithelial mesenchymal transition and stemness
    • Giannoni E, Bianchini F, Calorini L, Chiarugi P. 2011. Cancer associated fibroblasts exploit reactive oxygen species through a proinflammatory signature leading to epithelial mesenchymal transition and stemness. Antioxid Redox Signal 14:2361-2371.
    • (2011) Antioxid Redox Signal , vol.14 , pp. 2361-2371
    • Giannoni, E.1    Bianchini, F.2    Calorini, L.3    Chiarugi, P.4
  • 25
    • 77950346282 scopus 로고    scopus 로고
    • Immunity, inflammation, and cancer
    • Grivennikov SI, Greten FR, Karin M. 2010. Immunity, inflammation, and cancer. Cell 140:883-899.
    • (2010) Cell , vol.140 , pp. 883-899
    • Grivennikov, S.I.1    Greten, F.R.2    Karin, M.3
  • 26
    • 84871451335 scopus 로고    scopus 로고
    • Gastric cancer exosomes trigger differentiation of umbilical cord derived mesenchymal stem cells to carcinoma-associated fibroblasts through TGF-beta/Smad pathway
    • Gu J, Qian H, Shen L, Zhang X, Zhu W, Huang L, Yan Y, Mao F, Zhao C, Shi Y, Xu W. 2012. Gastric cancer exosomes trigger differentiation of umbilical cord derived mesenchymal stem cells to carcinoma-associated fibroblasts through TGF-beta/Smad pathway. PLoS ONE 7:e52465.
    • (2012) PLoS ONE , vol.7
    • Gu, J.1    Qian, H.2    Shen, L.3    Zhang, X.4    Zhu, W.5    Huang, L.6    Yan, Y.7    Mao, F.8    Zhao, C.9    Shi, Y.10    Xu, W.11
  • 27
    • 50349101081 scopus 로고    scopus 로고
    • Stromal fibroblasts activated by tumor cells promote angiogenesis in mouse gastric cancer
    • Guo X, Oshima H, Kitmura T, Taketo MM, Oshima M. 2008. Stromal fibroblasts activated by tumor cells promote angiogenesis in mouse gastric cancer. J Biol Chem 283:19864-19871.
    • (2008) J Biol Chem , vol.283 , pp. 19864-19871
    • Guo, X.1    Oshima, H.2    Kitmura, T.3    Taketo, M.M.4    Oshima, M.5
  • 28
    • 84858590826 scopus 로고    scopus 로고
    • Accessories to the crime: Functions of cells recruited to the tumor microenvironment
    • Hanahan D, Coussens LM. 2012. Accessories to the crime: Functions of cells recruited to the tumor microenvironment. Cancer Cell 21:309-322.
    • (2012) Cancer Cell , vol.21 , pp. 309-322
    • Hanahan, D.1    Coussens, L.M.2
  • 29
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: The next generation
    • Hanahan D, Weinberg RA. 2011. Hallmarks of cancer: The next generation. Cell 144:646-674.
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 31
    • 84864941779 scopus 로고    scopus 로고
    • Emerging roles of the tumor-associated stroma in promoting tumor metastasis
    • Horimoto Y, Polanska UM, Takahashi Y, Orimo A. 2012. Emerging roles of the tumor-associated stroma in promoting tumor metastasis. Cell Adhes Migr 6:193-202.
    • (2012) Cell Adhes Migr , vol.6 , pp. 193-202
    • Horimoto, Y.1    Polanska, U.M.2    Takahashi, Y.3    Orimo, A.4
  • 32
    • 77955029223 scopus 로고    scopus 로고
    • Breast carcinoma-associated fibroblasts rarely contain p53 mutations or chromosomal aberrations
    • Hosein AN, Wu M, Arcand SL, Lavallee S, Hebert J, Tonin PN, Basik M. 2010. Breast carcinoma-associated fibroblasts rarely contain p53 mutations or chromosomal aberrations. Cancer Res 70:5770-5777.
    • (2010) Cancer Res , vol.70 , pp. 5770-5777
    • Hosein, A.N.1    Wu, M.2    Arcand, S.L.3    Lavallee, S.4    Hebert, J.5    Tonin, P.N.6    Basik, M.7
  • 34
    • 62549099627 scopus 로고    scopus 로고
    • Role of COX-2 in epithelial-stromal cell interactions and progression of ductal carcinoma in situ of the breast
    • Hu M, Peluffo G, Chen H, Gelman R, Schnitt S, Polyak K. 2009. Role of COX-2 in epithelial-stromal cell interactions and progression of ductal carcinoma in situ of the breast. Proc Natl Acad Sci U S A 106:3372-3377.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 3372-3377
    • Hu, M.1    Peluffo, G.2    Chen, H.3    Gelman, R.4    Schnitt, S.5    Polyak, K.6
  • 36
    • 77952896646 scopus 로고    scopus 로고
    • TGFbeta signalling: A complex web in cancer progression
    • Ikushima H, Miyazono K. 2010. TGFbeta signalling: A complex web in cancer progression. Nat Rev Cancer 10:415-424.
    • (2010) Nat Rev Cancer , vol.10 , pp. 415-424
    • Ikushima, H.1    Miyazono, K.2
  • 39
    • 20444412646 scopus 로고    scopus 로고
    • Therapeutic targeting of the tumor microenvironment
    • Joyce JA. 2005. Therapeutic targeting of the tumor microenvironment. Cancer Cell 7:513-520.
    • (2005) Cancer Cell , vol.7 , pp. 513-520
    • Joyce, J.A.1
  • 45
    • 84857411051 scopus 로고    scopus 로고
    • Origins of the tumor microenvironment: Quantitative assessment of adipose-derived and bone marrow-derived stroma
    • Kidd S, Spaeth E, Watson K, Burks J, Lu H, Klopp A, Andreeff M, Marini FC. 2012. Origins of the tumor microenvironment: Quantitative assessment of adipose-derived and bone marrow-derived stroma. PLoS ONE 7:e30563.
    • (2012) PLoS ONE , vol.7
    • Kidd, S.1    Spaeth, E.2    Watson, K.3    Burks, J.4    Lu, H.5    Klopp, A.6    Andreeff, M.7    Marini, F.C.8
  • 50
    • 84859949610 scopus 로고    scopus 로고
    • The extracellular matrix: A dynamic niche in cancer progression
    • Lu P, Weaver VM, Werb Z. 2012. The extracellular matrix: A dynamic niche in cancer progression. J Cell Biol 196:395-406.
    • (2012) J Cell Biol , vol.196 , pp. 395-406
    • Lu, P.1    Weaver, V.M.2    Werb, Z.3
  • 54
    • 84866742560 scopus 로고    scopus 로고
    • TGFbeta signalling in context
    • Massague J. 2012. TGFbeta signalling in context. Nat Rev Mol Cell Biol 13:616-630.
    • (2012) Nat Rev Mol Cell Biol , vol.13 , pp. 616-630
    • Massague, J.1
  • 55
    • 79959238013 scopus 로고    scopus 로고
    • Microenvironmental regulation of stem cells in intestinal homeostasis and cancer
    • Medema JP, Vermeulen L. 2011. Microenvironmental regulation of stem cells in intestinal homeostasis and cancer. Nature 474:318-326.
    • (2011) Nature , vol.474 , pp. 318-326
    • Medema, J.P.1    Vermeulen, L.2
  • 56
    • 33749252188 scopus 로고    scopus 로고
    • Activated hepatic stellate cells induce tumor progression of neoplastic hepatocytes in a TGF-beta dependent fashion
    • Mikula M, Proell V, Fischer AN, Mikulits W. 2006. Activated hepatic stellate cells induce tumor progression of neoplastic hepatocytes in a TGF-beta dependent fashion. J Cell Physiol 209:560-567.
    • (2006) J Cell Physiol , vol.209 , pp. 560-567
    • Mikula, M.1    Proell, V.2    Fischer, A.N.3    Mikulits, W.4
  • 58
    • 79953220086 scopus 로고    scopus 로고
    • Ligand-independent activation of c-Met by fibronectin and alpha(5)beta(1)-integrin regulates ovarian cancer invasion and metastasis
    • Mitra AK, Sawada K, Tiwari P, Mui K, Gwin K, Lengyel E. 2011. Ligand-independent activation of c-Met by fibronectin and alpha(5)beta(1)-integrin regulates ovarian cancer invasion and metastasis. Oncogene 30:1566-1576.
    • (2011) Oncogene , vol.30 , pp. 1566-1576
    • Mitra, A.K.1    Sawada, K.2    Tiwari, P.3    Mui, K.4    Gwin, K.5    Lengyel, E.6
  • 63
    • 0033215242 scopus 로고    scopus 로고
    • Carcinoma-associated fibroblasts direct tumor progression of initiated human prostatic epithelium
    • Olumi AF, Grossfeld GD, Hayward SW, Carroll PR, Tlsty TD, Cunha GR. 1999. Carcinoma-associated fibroblasts direct tumor progression of initiated human prostatic epithelium. Cancer Res 59:5002-5011.
    • (1999) Cancer Res , vol.59 , pp. 5002-5011
    • Olumi, A.F.1    Grossfeld, G.D.2    Hayward, S.W.3    Carroll, P.R.4    Tlsty, T.D.5    Cunha, G.R.6
  • 64
  • 65
    • 41149157649 scopus 로고    scopus 로고
    • TGFbeta primes breast tumors for lung metastasis seeding through angiopoietin-like 4
    • Padua D, Zhang XH, Wang Q, Nadal C, Gerald WL, Gomis RR, Massague J. 2008. TGFbeta primes breast tumors for lung metastasis seeding through angiopoietin-like 4. Cell 133:66-77.
    • (2008) Cell , vol.133 , pp. 66-77
    • Padua, D.1    Zhang, X.H.2    Wang, Q.3    Nadal, C.4    Gerald, W.L.5    Gomis, R.R.6    Massague, J.7
  • 66
    • 50549121134 scopus 로고
    • The distribution of secondary growths in cacer of the breast
    • Paget S. 1889. The distribution of secondary growths in cacer of the breast. Lancet 133:571-573.
    • (1889) Lancet , vol.133 , pp. 571-573
    • Paget, S.1
  • 68
    • 77952568396 scopus 로고    scopus 로고
    • Hallmarks of cancer: Interactions with the tumor stroma
    • Pietras K, Ostman A. 2010. Hallmarks of cancer: Interactions with the tumor stroma. Exp Cell Res 316:1324-1331.
    • (2010) Exp Cell Res , vol.316 , pp. 1324-1331
    • Pietras, K.1    Ostman, A.2
  • 70
    • 38849202330 scopus 로고    scopus 로고
    • Functions of paracrine PDGF signaling in the proangiogenic tumor stroma revealed by pharmacological targeting
    • Pietras K, Pahler J, Bergers G, Hanahan D. 2008. Functions of paracrine PDGF signaling in the proangiogenic tumor stroma revealed by pharmacological targeting. PLoS Med 5:e19.
    • (2008) PLoS Med , vol.5
    • Pietras, K.1    Pahler, J.2    Bergers, G.3    Hanahan, D.4
  • 72
    • 58149345546 scopus 로고    scopus 로고
    • Co-evolution of tumor cells and their microenvironment
    • Polyak K, Haviv I, Campbell IG. 2009. Co-evolution of tumor cells and their microenvironment. Trends Genet 25:30-38.
    • (2009) Trends Genet , vol.25 , pp. 30-38
    • Polyak, K.1    Haviv, I.2    Campbell, I.G.3
  • 74
    • 84858602107 scopus 로고    scopus 로고
    • Enzymatic targeting of the stroma ablates physical barriers to treatment of pancreatic ductal adenocarcinoma
    • Provenzano PP, Cuevas C, Chang AE, Goel VK, Von Hoff DD, Hingorani SR. 2012. Enzymatic targeting of the stroma ablates physical barriers to treatment of pancreatic ductal adenocarcinoma. Cancer Cell 21:418-429.
    • (2012) Cancer Cell , vol.21 , pp. 418-429
    • Provenzano, P.P.1    Cuevas, C.2    Chang, A.E.3    Goel, V.K.4    Von Hoff, D.D.5    Hingorani, S.R.6
  • 76
    • 77956883321 scopus 로고    scopus 로고
    • Activation of fibroblasts in cancer stroma
    • Rasanen K, Vaheri A. 2010. Activation of fibroblasts in cancer stroma. Exp Cell Res 316:2713-2722.
    • (2010) Exp Cell Res , vol.316 , pp. 2713-2722
    • Rasanen, K.1    Vaheri, A.2
  • 77
    • 0027161705 scopus 로고
    • Induction of alpha-smooth muscle actin by transforming growth factor-beta 1 in quiescent human breast gland fibroblasts. Implications for myofibroblast generation in breast neoplasia
    • Ronnov-Jessen L, Petersen OW. 1993. Induction of alpha-smooth muscle actin by transforming growth factor-beta 1 in quiescent human breast gland fibroblasts. Implications for myofibroblast generation in breast neoplasia. Lab Invest 68:696-707.
    • (1993) Lab Invest , vol.68 , pp. 696-707
    • Ronnov-Jessen, L.1    Petersen, O.W.2
  • 79
    • 47749139256 scopus 로고    scopus 로고
    • Cancer as an overhealing wound: An old hypothesis revisited
    • Schafer M, Werner S. 2008. Cancer as an overhealing wound: An old hypothesis revisited. Nat Rev Mol Cell Biol 9:628-638.
    • (2008) Nat Rev Mol Cell Biol , vol.9 , pp. 628-638
    • Schafer, M.1    Werner, S.2
  • 80
    • 0033178473 scopus 로고    scopus 로고
    • Mechanisms of myofibroblast activity and phenotypic modulation
    • Serini G, Gabbiani G. 1999. Mechanisms of myofibroblast activity and phenotypic modulation. Exp Cell Res 250:273-283.
    • (1999) Exp Cell Res , vol.250 , pp. 273-283
    • Serini, G.1    Gabbiani, G.2
  • 82
    • 75849159205 scopus 로고    scopus 로고
    • Carcinoma-associated fibroblasts are a rate-limiting determinant for tumour progression
    • Shimoda M, Mellody KT, Orimo A. 2010. Carcinoma-associated fibroblasts are a rate-limiting determinant for tumour progression. Semin Cell Dev Biol 21:19-25.
    • (2010) Semin Cell Dev Biol , vol.21 , pp. 19-25
    • Shimoda, M.1    Mellody, K.T.2    Orimo, A.3
  • 84
    • 64549145804 scopus 로고    scopus 로고
    • Mesenchymal stem cell transition to tumor-associated fibroblasts contributes to fibrovascular network expansion and tumor progression
    • Spaeth EL, Dembinski JL, Sasser AK, Watson K, Klopp A, Hall B, Andreeff M, Marini F. 2009. Mesenchymal stem cell transition to tumor-associated fibroblasts contributes to fibrovascular network expansion and tumor progression. PLoS ONE 4:e4992.
    • (2009) PLoS ONE , vol.4
    • Spaeth, E.L.1    Dembinski, J.L.2    Sasser, A.K.3    Watson, K.4    Klopp, A.5    Hall, B.6    Andreeff, M.7    Marini, F.8
  • 85
    • 34447261691 scopus 로고    scopus 로고
    • A delicate balance: TGF-beta and the tumor microenvironment
    • Stover DG, Bierie B, Moses HL. 2007. A delicate balance: TGF-beta and the tumor microenvironment. J Cell Biochem 101:851-861.
    • (2007) J Cell Biochem , vol.101 , pp. 851-861
    • Stover, D.G.1    Bierie, B.2    Moses, H.L.3
  • 87
    • 33846967113 scopus 로고    scopus 로고
    • Identification of fibroblast heterogeneity in the tumor microenvironment
    • Sugimoto H, Mundel TM, Kieran MW, Kalluri R. 2006. Identification of fibroblast heterogeneity in the tumor microenvironment. Cancer Biol Ther 5:1640-1646.
    • (2006) Cancer Biol Ther , vol.5 , pp. 1640-1646
    • Sugimoto, H.1    Mundel, T.M.2    Kieran, M.W.3    Kalluri, R.4
  • 88
    • 84868633053 scopus 로고    scopus 로고
    • Treatment-induced damage to the tumor microenvironment promotes prostate cancer therapy resistance through WNT16B
    • Sun Y, Campisi J, Higano C, Beer TM, Porter P, Coleman I, True L, Nelson PS. 2012. Treatment-induced damage to the tumor microenvironment promotes prostate cancer therapy resistance through WNT16B. Nat Med 18:1359-1368.
    • (2012) Nat Med , vol.18 , pp. 1359-1368
    • Sun, Y.1    Campisi, J.2    Higano, C.3    Beer, T.M.4    Porter, P.5    Coleman, I.6    True, L.7    Nelson, P.S.8
  • 89
    • 70450198396 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transitions in development and disease
    • Thiery JP, Acloque H, Huang RY, Nieto MA. 2009. Epithelial-mesenchymal transitions in development and disease. Cell 139:871-890.
    • (2009) Cell , vol.139 , pp. 871-890
    • Thiery, J.P.1    Acloque, H.2    Huang, R.Y.3    Nieto, M.A.4
  • 90
    • 84875234222 scopus 로고    scopus 로고
    • Carcinoma-associated fibroblasts are a promising therapeutic target
    • Togo S, Polanska UM, Horimoto Y, Orimo A. 2013. Carcinoma-associated fibroblasts are a promising therapeutic target. Cancers 5:149-169.
    • (2013) Cancers , vol.5 , pp. 149-169
    • Togo, S.1    Polanska, U.M.2    Horimoto, Y.3    Orimo, A.4
  • 93
    • 84870845421 scopus 로고    scopus 로고
    • Spatiotemporal regulation of epithelial-mesenchymal transition is essential for squamous cell carcinoma metastasis
    • Tsai JH, Donaher JL, Murphy DA, Chau S, Yang J. 2012. Spatiotemporal regulation of epithelial-mesenchymal transition is essential for squamous cell carcinoma metastasis. Cancer Cell 22:725-736.
    • (2012) Cancer Cell , vol.22 , pp. 725-736
    • Tsai, J.H.1    Donaher, J.L.2    Murphy, D.A.3    Chau, S.4    Yang, J.5
  • 100
    • 33750798741 scopus 로고    scopus 로고
    • The chemokine growth-regulated oncogene 1 (Gro-1) links RAS signaling to the senescence of stromal fibroblasts and ovarian tumorigenesis
    • Yang G, Rosen DG, Zhang Z, Bast RC, Jr., Mills GB, Colacino JA, Mercado-Uribe I, Liu J. 2006. The chemokine growth-regulated oncogene 1 (Gro-1) links RAS signaling to the senescence of stromal fibroblasts and ovarian tumorigenesis. Proc Natl Acad Sci U S A 103:16472-16477.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 16472-16477
    • Yang, G.1    Rosen, D.G.2    Zhang, Z.3    Bast Jr., R.C.4    Mills, G.B.5    Colacino, J.A.6    Mercado-Uribe, I.7    Liu, J.8
  • 102
    • 79551693066 scopus 로고    scopus 로고
    • Circulating tumor cells: Approaches to isolation and characterization
    • Yu M, Stott S, Toner M, Maheswaran S, Haber DA. 2011. Circulating tumor cells: Approaches to isolation and characterization. J Cell Biol 192:373-382.
    • (2011) J Cell Biol , vol.192 , pp. 373-382
    • Yu, M.1    Stott, S.2    Toner, M.3    Maheswaran, S.4    Haber, D.A.5
  • 103
    • 84866306531 scopus 로고    scopus 로고
    • Unlike pancreatic cancer cells pancreatic cancer associated fibroblasts display minimal gene induction after 5-aza-2′-deoxycytidine
    • Yu J, Walter K, Omura N, Hong SM, Young A, Li A, Vincent A, Goggins M. 2012. Unlike pancreatic cancer cells pancreatic cancer associated fibroblasts display minimal gene induction after 5-aza-2′-deoxycytidine. PLoS ONE 7:e43456.
    • (2012) PLoS ONE , vol.7
    • Yu, J.1    Walter, K.2    Omura, N.3    Hong, S.M.4    Young, A.5    Li, A.6    Vincent, A.7    Goggins, M.8
  • 104
    • 35948945337 scopus 로고    scopus 로고
    • Discovery of endothelial to mesenchymal transition as a source for carcinoma-associated fibroblasts
    • Zeisberg EM, Potenta S, Xie L, Zeisberg M, Kalluri R. 2007. Discovery of endothelial to mesenchymal transition as a source for carcinoma-associated fibroblasts. Cancer Res 67:10123-10128.
    • (2007) Cancer Res , vol.67 , pp. 10123-10128
    • Zeisberg, E.M.1    Potenta, S.2    Xie, L.3    Zeisberg, M.4    Kalluri, R.5
  • 105
    • 57149112760 scopus 로고    scopus 로고
    • Targeting the stroma by T cells to limit tumor growth
    • Zhang B. 2008. Targeting the stroma by T cells to limit tumor growth. Cancer Res 68:9570-9573.
    • (2008) Cancer Res , vol.68 , pp. 9570-9573
    • Zhang, B.1


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