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Volumn 35, Issue 4, 2015, Pages 361-374

Genetics of Alcoholic Liver Disease

Author keywords

alcoholic liver disease; gene; polymorphism; steatohepatitis

Indexed keywords

CYTOKINE; ENDOTOXIN; PATATIN LIKE PHOSPHOLIPASE DOMAIN CONTAINING PROTEIN 3; PROTEIN; TOLL LIKE RECEPTOR 4; UNCLASSIFIED DRUG; ADIPONUTRIN, HUMAN; ALCOHOL; MEMBRANE PROTEIN; TLR4 PROTEIN, HUMAN; TM6SF2 PROTEIN, HUMAN; TRIACYLGLYCEROL LIPASE;

EID: 84949967608     PISSN: 02728087     EISSN: 10988971     Source Type: Journal    
DOI: 10.1055/s-0035-1567832     Document Type: Article
Times cited : (40)

References (163)
  • 1
    • 84879143879 scopus 로고    scopus 로고
    • Global burden of alcoholic liver diseases
    • Rehm J., Samokhvalov A. V., Shield K. D. Global burden of alcoholic liver diseases. J Hepatol: 2013; 59 1 160 168
    • (2013) J Hepatol , vol.59 , Issue.1 , pp. 160-168
    • Rehm, J.1    Samokhvalov, A.V.2    Shield, K.D.3
  • 2
    • 0029165057 scopus 로고
    • Determinants of progression to cirrhosis or fibrosis in pure alcoholic fatty liver
    • Teli M. R., Day C. P., Burt A. D., Bennett M. K., James O. F. Determinants of progression to cirrhosis or fibrosis in pure alcoholic fatty liver. Lancet: 1995; 346 8981 987 990
    • (1995) Lancet , vol.346 , Issue.8981 , pp. 987-990
    • Teli, M.R.1    Day, C.P.2    Burt, A.D.3    Bennett, M.K.4    James, O.F.5
  • 3
    • 84878930738 scopus 로고    scopus 로고
    • Progression of NAFLD to diabetes mellitus, cardiovascular disease or cirrhosis
    • Anstee Q. M., Targher G., Day C. P. Progression of NAFLD to diabetes mellitus, cardiovascular disease or cirrhosis. Nat Rev Gastroenterol Hepatol: 2013; 10 6 330 344
    • (2013) Nat Rev Gastroenterol Hepatol , vol.10 , Issue.6 , pp. 330-344
    • Anstee, Q.M.1    Targher, G.2    Day, C.P.3
  • 4
    • 0000156898 scopus 로고
    • Effects of prolonged ethanol intake: Production of fatty liver despite adequate diets
    • Lieber C. S., Jones D. P., Decarli L. M. Effects of prolonged ethanol intake: production of fatty liver despite adequate diets. J Clin Invest: 1965; 44 1009 1021
    • (1965) J Clin Invest , vol.44 , pp. 1009-1021
    • Lieber, C.S.1    Jones, D.P.2    Decarli, L.M.3
  • 5
    • 0017126263 scopus 로고
    • Animal models of ethanol dependence and liver injury in rats and baboons
    • Lieber C. S., Decarli L. M. Animal models of ethanol dependence and liver injury in rats and baboons. Fed Proc: 1976; 35 5 1232 1236
    • (1976) Fed Proc , vol.35 , Issue.5 , pp. 1232-1236
    • Lieber, C.S.1    Decarli, L.M.2
  • 6
    • 84869089319 scopus 로고    scopus 로고
    • Rodent models of alcoholic liver disease: Of mice and men
    • Brandon-Warner E., Schrum L. W., Schmidt C. M., McKillop I. H. Rodent models of alcoholic liver disease: of mice and men. Alcohol: 2012; 46 8 715 725
    • (2012) Alcohol , vol.46 , Issue.8 , pp. 715-725
    • Brandon-Warner, E.1    Schrum, L.W.2    Schmidt, C.M.3    McKillop, I.H.4
  • 7
    • 6844258880 scopus 로고    scopus 로고
    • Drinking habits as cofactors of risk for alcohol induced liver damage
    • The Dionysos Study Group.
    • Bellentani S., Saccoccio G., Costa G., et al. The Dionysos Study Group. Drinking habits as cofactors of risk for alcohol induced liver damage. Gut: 1997; 41 6 845 850
    • (1997) Gut , vol.41 , Issue.6 , pp. 845-850
    • Bellentani, S.1    Saccoccio, G.2    Costa, G.3
  • 8
    • 0029869768 scopus 로고    scopus 로고
    • Prediction of risk of liver disease by alcohol intake, sex, and age: A prospective population study
    • Becker U., Deis A., Sorensen T. I., et al. Prediction of risk of liver disease by alcohol intake, sex, and age: a prospective population study. Hepatology: 1996; 23 5 1025 1029
    • (1996) Hepatology , vol.23 , Issue.5 , pp. 1025-1029
    • Becker, U.1    Deis, A.2    Sorensen, T.I.3
  • 9
    • 0031041924 scopus 로고    scopus 로고
    • Morbidity and mortality in compensated cirrhosis type C: A retrospective follow-up study of 384 patients
    • Fattovich G., Giustina G., Degos F., et al. Morbidity and mortality in compensated cirrhosis type C: a retrospective follow-up study of 384 patients. Gastroenterology: 1997; 112 2 463 472
    • (1997) Gastroenterology , vol.112 , Issue.2 , pp. 463-472
    • Fattovich, G.1    Giustina, G.2    Degos, F.3
  • 10
    • 79955663416 scopus 로고    scopus 로고
    • Genetics of alcoholic and nonalcoholic fatty liver disease
    • Anstee Q. M., Daly A. K., Day C. P. Genetics of alcoholic and nonalcoholic fatty liver disease. Semin Liver Dis: 2011; 31 2 128 146
    • (2011) Semin Liver Dis , vol.31 , Issue.2 , pp. 128-146
    • Anstee, Q.M.1    Daly, A.K.2    Day, C.P.3
  • 11
    • 84927797921 scopus 로고    scopus 로고
    • Alcohol drinking pattern and risk of alcoholic liver cirrhosis: A prospective cohort study
    • Askgaard G., Gronbæk M., Kjær M. S., Tjonneland A., Tolstrup J. S. Alcohol drinking pattern and risk of alcoholic liver cirrhosis: a prospective cohort study. J Hepatol: 2015; 62 5 1061 1067
    • (2015) J Hepatol , vol.62 , Issue.5 , pp. 1061-1067
    • Askgaard, G.1    Gronbæk, M.2    Kjær, M.S.3    Tjonneland, A.4    Tolstrup, J.S.5
  • 13
    • 18344371820 scopus 로고    scopus 로고
    • Lower risk for alcohol-induced cirrhosis in wine drinkers
    • Becker U., Gronbaek M., Johansen D., Sorensen T. I. Lower risk for alcohol-induced cirrhosis in wine drinkers. Hepatology: 2002; 35 4 868 875
    • (2002) Hepatology , vol.35 , Issue.4 , pp. 868-875
    • Becker, U.1    Gronbaek, M.2    Johansen, D.3    Sorensen, T.I.4
  • 14
    • 33644911178 scopus 로고    scopus 로고
    • Food buying habits of people who buy wine or beer: Cross sectional study
    • Johansen D., Friis K., Skovenborg E., Gronbaek M. Food buying habits of people who buy wine or beer: cross sectional study. BMJ: 2006; 332 7540 519 522
    • (2006) BMJ , vol.332 , Issue.7540 , pp. 519-522
    • Johansen, D.1    Friis, K.2    Skovenborg, E.3    Gronbaek, M.4
  • 15
    • 0025006941 scopus 로고
    • Diet and alcohol in liver cirrhosis: A case-control study
    • Rotily M., Durbec J. P., Berthézène P., Sarles H. Diet and alcohol in liver cirrhosis: a case-control study. Eur J Clin Nutr: 1990; 44 8 595 603
    • (1990) Eur J Clin Nutr , vol.44 , Issue.8 , pp. 595-603
    • Rotily, M.1    Durbec, J.P.2    Berthézène, P.3    Sarles, H.4
  • 16
    • 0023902215 scopus 로고
    • Overweight as a risk factor or a predictive sign of histological liver damage in alcoholics
    • Iturriaga H., Bunout D., Hirsch S., Ugarte G. Overweight as a risk factor or a predictive sign of histological liver damage in alcoholics. Am J Clin Nutr: 1988; 47 2 235 238
    • (1988) Am J Clin Nutr , vol.47 , Issue.2 , pp. 235-238
    • Iturriaga, H.1    Bunout, D.2    Hirsch, S.3    Ugarte, G.4
  • 17
    • 77949706662 scopus 로고    scopus 로고
    • Body mass index and risk of liver cirrhosis in middle aged UK women: Prospective study
    • Million Women Study Collaborators.
    • Liu B., Balkwill A., Reeves G., Beral V.; Million Women Study Collaborators. Body mass index and risk of liver cirrhosis in middle aged UK women: prospective study. BMJ: 2010; 340 c912
    • (2010) BMJ , vol.340 , pp. c912
    • Liu, B.1    Balkwill, A.2    Reeves, G.3    Beral, V.4
  • 18
    • 77949751643 scopus 로고    scopus 로고
    • Effect of body mass index and alcohol consumption on liver disease: Analysis of data from two prospective cohort studies
    • Hart C. L., Morrison D. S., Batty G. D., Mitchell R. J., Davey Smith G. Effect of body mass index and alcohol consumption on liver disease: analysis of data from two prospective cohort studies. BMJ: 2010; 340 c1240
    • (2010) BMJ , vol.340 , pp. c1240
    • Hart, C.L.1    Morrison, D.S.2    Batty, G.D.3    Mitchell, R.J.4    Davey Smith, G.5
  • 19
    • 0036829092 scopus 로고    scopus 로고
    • AGA technical review on nonalcoholic fatty liver disease
    • American Gastroenterological Association.
    • Sanyal A. J.; American Gastroenterological Association. AGA technical review on nonalcoholic fatty liver disease. Gastroenterology: 2002; 123 5 1705 1725
    • (2002) Gastroenterology , vol.123 , Issue.5 , pp. 1705-1725
    • Sanyal, A.J.1
  • 20
    • 0033231294 scopus 로고    scopus 로고
    • Association of nonalcoholic fatty liver disease with insulin resistance
    • Marchesini G., Brizi M., Morselli-Labate A. M., et al. Association of nonalcoholic fatty liver disease with insulin resistance. Am J Med: 1999; 107 5 450 455
    • (1999) Am J Med , vol.107 , Issue.5 , pp. 450-455
    • Marchesini, G.1    Brizi, M.2    Morselli-Labate, A.M.3
  • 21
    • 0025178612 scopus 로고
    • The natural history of nonalcoholic steatohepatitis: A follow-up study of forty-two patients for up to 21 years
    • Powell E. E., Cooksley W. G., Hanson R., Searle J., Halliday J. W., Powell L. W. The natural history of nonalcoholic steatohepatitis: a follow-up study of forty-two patients for up to 21 years. Hepatology: 1990; 11 1 74 80
    • (1990) Hepatology , vol.11 , Issue.1 , pp. 74-80
    • Powell, E.E.1    Cooksley, W.G.2    Hanson, R.3    Searle, J.4    Halliday, J.W.5    Powell, L.W.6
  • 22
    • 0036185832 scopus 로고    scopus 로고
    • Risk factors of fibrosis in alcohol-induced liver disease
    • Raynard B., Balian A., Fallik D., et al. Risk factors of fibrosis in alcohol-induced liver disease. Hepatology: 2002; 35 3 635 638
    • (2002) Hepatology , vol.35 , Issue.3 , pp. 635-638
    • Raynard, B.1    Balian, A.2    Fallik, D.3
  • 23
    • 0030933395 scopus 로고    scopus 로고
    • Natural history of liver fibrosis progression in patients with chronic hepatitis C. the OBSVIRC, METAVIR, CLINIVIR, and DOSVIRC groups
    • Poynard T., Bedossa P., Opolon P. Natural history of liver fibrosis progression in patients with chronic hepatitis C. The OBSVIRC, METAVIR, CLINIVIR, and DOSVIRC groups. Lancet: 1997; 349 9055 825 832
    • (1997) Lancet , vol.349 , Issue.9055 , pp. 825-832
    • Poynard, T.1    Bedossa, P.2    Opolon, P.3
  • 24
    • 0035009810 scopus 로고    scopus 로고
    • Rates and risk factors of liver fibrosis progression in patients with chronic hepatitis c
    • Poynard T., Ratziu V., Charlotte F., Goodman Z., McHutchison J., Albrecht J. Rates and risk factors of liver fibrosis progression in patients with chronic hepatitis c. J Hepatol: 2001; 34 5 730 739
    • (2001) J Hepatol , vol.34 , Issue.5 , pp. 730-739
    • Poynard, T.1    Ratziu, V.2    Charlotte, F.3    Goodman, Z.4    McHutchison, J.5    Albrecht, J.6
  • 25
    • 79959524146 scopus 로고    scopus 로고
    • A haplotype map of the human genome
    • [Anonymous] International HapMap Consortium A haplotype map of the human genome. Nature: 2005; 437 7063 1299 1320
    • (2005) Nature , vol.437 , Issue.7063 , pp. 1299-1320
  • 26
    • 35348983887 scopus 로고    scopus 로고
    • A second generation human haplotype map of over 3.1 million SNPs
    • International HapMap Consortium.
    • Frazer K. A., Ballinger D. G., Cox D. R., et al. International HapMap Consortium. A second generation human haplotype map of over 3.1 million SNPs. Nature: 2007; 449 7164 851 861
    • (2007) Nature , vol.449 , Issue.7164 , pp. 851-861
    • Frazer, K.A.1    Ballinger, D.G.2    Cox, D.R.3
  • 27
    • 43049146524 scopus 로고    scopus 로고
    • A HapMap harvest of insights into the genetics of common disease
    • Manolio T. A., Brooks L. D., Collins F. S. A HapMap harvest of insights into the genetics of common disease. J Clin Invest: 2008; 118 5 1590 1605
    • (2008) J Clin Invest , vol.118 , Issue.5 , pp. 1590-1605
    • Manolio, T.A.1    Brooks, L.D.2    Collins, F.S.3
  • 28
    • 65949104586 scopus 로고    scopus 로고
    • Genomewide association studies and human disease
    • Hardy J., Singleton A. Genomewide association studies and human disease. N Engl J Med: 2009; 360 17 1759 1768
    • (2009) N Engl J Med , vol.360 , Issue.17 , pp. 1759-1768
    • Hardy, J.1    Singleton, A.2
  • 29
    • 13144306071 scopus 로고    scopus 로고
    • Genome-wide association studies for common diseases and complex traits
    • Hirschhorn J. N., Daly M. J. Genome-wide association studies for common diseases and complex traits. Nat Rev Genet: 2005; 6 2 95 108
    • (2005) Nat Rev Genet , vol.6 , Issue.2 , pp. 95-108
    • Hirschhorn, J.N.1    Daly, M.J.2
  • 30
    • 84941885943 scopus 로고    scopus 로고
    • The genetics of non-alcoholic fatty liver disease: Spotlight on PNPLA3 and TM6SF2
    • Anstee Q., Day C. The genetics of non-alcoholic fatty liver disease: spotlight on PNPLA3 and TM6SF2. Semin Liver Dis: 2015; 35 3 270 290
    • (2015) Semin Liver Dis , vol.35 , Issue.3 , pp. 270-290
    • Anstee, Q.1    Day, C.2
  • 31
    • 85061424653 scopus 로고    scopus 로고
    • Identifying genetic variation for alcohol dependence
    • Agrawal A., Bierut L. J. Identifying genetic variation for alcohol dependence. Alcohol Res: 2012; 34 3 274 281
    • (2012) Alcohol Res , vol.34 , Issue.3 , pp. 274-281
    • Agrawal, A.1    Bierut, L.J.2
  • 32
    • 84949089603 scopus 로고    scopus 로고
    • A genome-wide association study confirms PNPLA3 and identifies TM6SF2 and MBOAT7 as risk loci for alcohol-related cirrhosis
    • in press
    • Buch S., Stickel F., Trepo E., et al. A genome-wide association study confirms PNPLA3 and identifies TM6SF2 and MBOAT7 as risk loci for alcohol-related cirrhosis. Nat Genet: 2015;; in press
    • (2015) Nat Genet
    • Buch, S.1    Stickel, F.2    Trepo, E.3
  • 33
    • 84927585224 scopus 로고    scopus 로고
    • Brief report: Genetics of alcoholic cirrhosis-GenomALC multinational study
    • GenomALC Consortium.
    • Whitfield J. B., Rahman K., Haber P. S., et al. GenomALC Consortium. Brief report: genetics of alcoholic cirrhosis-GenomALC multinational study. Alcohol Clin Exp Res: 2015; 39 5 836 842
    • (2015) Alcohol Clin Exp Res , vol.39 , Issue.5 , pp. 836-842
    • Whitfield, J.B.1    Rahman, K.2    Haber, P.S.3
  • 34
    • 0034425410 scopus 로고    scopus 로고
    • A systematic, genome-wide, phenotype-driven mutagenesis programme for gene function studies in the mouse
    • Nolan P. M., Peters J., Strivens M., et al. A systematic, genome-wide, phenotype-driven mutagenesis programme for gene function studies in the mouse. Nat Genet: 2000; 25 4 440 443
    • (2000) Nat Genet , vol.25 , Issue.4 , pp. 440-443
    • Nolan, P.M.1    Peters, J.2    Strivens, M.3
  • 35
    • 1542563409 scopus 로고    scopus 로고
    • Initial sequencing and comparative analysis of the mouse genome
    • Mouse Genome Sequencing Consortium.
    • Waterston R. H., Lindblad-Toh K., Birney E., et al. Mouse Genome Sequencing Consortium. Initial sequencing and comparative analysis of the mouse genome. Nature: 2002; 420 6915 520 562
    • (2002) Nature , vol.420 , Issue.6915 , pp. 520-562
    • Waterston, R.H.1    Lindblad-Toh, K.2    Birney, E.3
  • 37
    • 84913594397 scopus 로고    scopus 로고
    • Genome editing. the new frontier of genome engineering with CRISPR-Cas9
    • Doudna J. A., Charpentier E. Genome editing. The new frontier of genome engineering with CRISPR-Cas9. Science: 2014; 346 6213 1258096
    • (2014) Science , vol.346 , Issue.6213 , pp. 1258096
    • Doudna, J.A.1    Charpentier, E.2
  • 38
    • 84928205754 scopus 로고    scopus 로고
    • High-throughput functional genomics using CRISPR-Cas9
    • Shalem O., Sanjana N. E., Zhang F. High-throughput functional genomics using CRISPR-Cas9. Nat Rev Genet: 2015; 16 5 299 311
    • (2015) Nat Rev Genet , vol.16 , Issue.5 , pp. 299-311
    • Shalem, O.1    Sanjana, N.E.2    Zhang, F.3
  • 40
    • 84889568060 scopus 로고    scopus 로고
    • Mutations in the Gabrb1 gene promote alcohol consumption through increased tonic inhibition
    • Anstee Q. M., Knapp S., Maguire E. P., et al. Mutations in the Gabrb1 gene promote alcohol consumption through increased tonic inhibition. Nat Commun: 2013; 4 2816
    • (2013) Nat Commun , vol.4 , pp. 2816
    • Anstee, Q.M.1    Knapp, S.2    Maguire, E.P.3
  • 41
    • 2942522762 scopus 로고    scopus 로고
    • The 12-month prevalence and trends in DSM-IV alcohol abuse and dependence: United States, 1991-1992 and 2001-2002
    • Grant B. F., Dawson D. A., Stinson F. S., Chou S. P., Dufour M. C., Pickering R. P. The 12-month prevalence and trends in DSM-IV alcohol abuse and dependence: United States, 1991-1992 and 2001-2002. Drug Alcohol Depend: 2004; 74 3 223 234
    • (2004) Drug Alcohol Depend , vol.74 , Issue.3 , pp. 223-234
    • Grant, B.F.1    Dawson, D.A.2    Stinson, F.S.3    Chou, S.P.4    Dufour, M.C.5    Pickering, R.P.6
  • 42
    • 0031791365 scopus 로고    scopus 로고
    • Familial transmission of substance dependence: Alcohol, marijuana, cocaine, and habitual smoking: A report from the Collaborative Study on the Genetics of Alcoholism
    • Bierut L. J., Dinwiddie S. H., Begleiter H., et al. Familial transmission of substance dependence: alcohol, marijuana, cocaine, and habitual smoking: a report from the Collaborative Study on the Genetics of Alcoholism. Arch Gen Psychiatry: 1998; 55 11 982 988
    • (1998) Arch Gen Psychiatry , vol.55 , Issue.11 , pp. 982-988
    • Bierut, L.J.1    Dinwiddie, S.H.2    Begleiter, H.3
  • 43
    • 0020966737 scopus 로고
    • Familial alcoholism and problem drinking in a national drinking practices survey
    • Midanik L. Familial alcoholism and problem drinking in a national drinking practices survey. Addict Behav: 1983; 8 2 133 141
    • (1983) Addict Behav , vol.8 , Issue.2 , pp. 133-141
    • Midanik, L.1
  • 44
    • 45349094513 scopus 로고    scopus 로고
    • Are there genetic influences on addiction: Evidence from family, adoption and twin studies
    • Agrawal A., Lynskey M. T. Are there genetic influences on addiction: evidence from family, adoption and twin studies. Addiction: 2008; 103 7 1069 1081
    • (2008) Addiction , vol.103 , Issue.7 , pp. 1069-1081
    • Agrawal, A.1    Lynskey, M.T.2
  • 45
    • 44649088160 scopus 로고    scopus 로고
    • The role of GABA(A) receptors in the development of alcoholism
    • Enoch M. A. The role of GABA(A) receptors in the development of alcoholism. Pharmacol Biochem Behav: 2008; 90 1 95 104
    • (2008) Pharmacol Biochem Behav , vol.90 , Issue.1 , pp. 95-104
    • Enoch, M.A.1
  • 46
    • 21344469970 scopus 로고    scopus 로고
    • The genetics of addictions: Uncovering the genes
    • Goldman D., Oroszi G., Ducci F. The genetics of addictions: uncovering the genes. Nat Rev Genet: 2005; 6 7 521 532
    • (2005) Nat Rev Genet , vol.6 , Issue.7 , pp. 521-532
    • Goldman, D.1    Oroszi, G.2    Ducci, F.3
  • 47
    • 58149347486 scopus 로고    scopus 로고
    • Genome-wide association studies: Potential next steps on a genetic journey
    • (R2)
    • McCarthy M. I., Hirschhorn J. N. Genome-wide association studies: potential next steps on a genetic journey. Hum Mol Genet: 2008; 17 (R2): R156 R165
    • (2008) Hum Mol Genet , vol.17 , pp. R156-R165
    • McCarthy, M.I.1    Hirschhorn, J.N.2
  • 48
    • 0031799363 scopus 로고    scopus 로고
    • International Union of Pharmacology. XV. Subtypes of gamma-aminobutyric acidA receptors: Classification on the basis of subunit structure and receptor function
    • Barnard E. A., Skolnick P., Olsen R. W., et al. International Union of Pharmacology. XV. Subtypes of gamma-aminobutyric acidA receptors: classification on the basis of subunit structure and receptor function. Pharmacol Rev: 1998; 50 2 291 313
    • (1998) Pharmacol Rev , vol.50 , Issue.2 , pp. 291-313
    • Barnard, E.A.1    Skolnick, P.2    Olsen, R.W.3
  • 49
    • 0032496340 scopus 로고    scopus 로고
    • Evidence for genetic linkage to alcohol dependence on chromosomes 4 and 11 from an autosome-wide scan in an American Indian population
    • Long J. C., Knowler W. C., Hanson R. L., et al. Evidence for genetic linkage to alcohol dependence on chromosomes 4 and 11 from an autosome-wide scan in an American Indian population. Am J Med Genet: 1998; 81 3 216 221
    • (1998) Am J Med Genet , vol.81 , Issue.3 , pp. 216-221
    • Long, J.C.1    Knowler, W.C.2    Hanson, R.L.3
  • 50
    • 0033365229 scopus 로고    scopus 로고
    • Joint multipoint linkage analysis of multivariate qualitative and quantitative traits. II. Alcoholism and event-related potentials
    • Williams J. T., Begleiter H., Porjesz B., et al. Joint multipoint linkage analysis of multivariate qualitative and quantitative traits. II. Alcoholism and event-related potentials. Am J Hum Genet: 1999; 65 4 1148 1160
    • (1999) Am J Hum Genet , vol.65 , Issue.4 , pp. 1148-1160
    • Williams, J.T.1    Begleiter, H.2    Porjesz, B.3
  • 51
    • 0032496312 scopus 로고    scopus 로고
    • Genome-wide search for genes affecting the risk for alcohol dependence
    • Reich T., Edenberg H. J., Goate A., et al. Genome-wide search for genes affecting the risk for alcohol dependence. Am J Med Genet: 1998; 81 3 207 215
    • (1998) Am J Med Genet , vol.81 , Issue.3 , pp. 207-215
    • Reich, T.1    Edenberg, H.J.2    Goate, A.3
  • 52
    • 18344368607 scopus 로고    scopus 로고
    • Linkage disequilibrium between the beta frequency of the human EEG and a GABAA receptor gene locus
    • Porjesz B., Almasy L., Edenberg H. J., et al. Linkage disequilibrium between the beta frequency of the human EEG and a GABAA receptor gene locus. Proc Natl Acad Sci U S A: 2002; 99 6 3729 3733
    • (2002) Proc Natl Acad Sci U S A , vol.99 , Issue.6 , pp. 3729-3733
    • Porjesz, B.1    Almasy, L.2    Edenberg, H.J.3
  • 53
    • 0032708084 scopus 로고    scopus 로고
    • Genome search for alcohol dependence using the weighted pairwise correlation linkage method: Interesting findings on chromosome 4
    • 01
    • Zinn-Justin A., Abel L. Genome search for alcohol dependence using the weighted pairwise correlation linkage method: interesting findings on chromosome 4. Genet Epidemiol: 1999; 17 01 S421 S426
    • (1999) Genet Epidemiol , vol.17 , pp. S421-S426
    • Zinn-Justin, A.1    Abel, L.2
  • 54
    • 0041317801 scopus 로고    scopus 로고
    • Linkage mapping of beta 2 EEG waves via non-parametric regression
    • Ghosh S., Begleiter H., Porjesz B., et al. Linkage mapping of beta 2 EEG waves via non-parametric regression. Am J Med Genet B Neuropsychiatr Genet: 2003; 118B 1 66 71
    • (2003) Am J Med Genet B Neuropsychiatr Genet , vol.118 B , Issue.1 , pp. 66-71
    • Ghosh, S.1    Begleiter, H.2    Porjesz, B.3
  • 55
    • 12144288685 scopus 로고    scopus 로고
    • Variations in GABRA2, encoding the alpha 2 subunit of the GABA(A) receptor, are associated with alcohol dependence and with brain oscillations
    • Edenberg H. J., Dick D. M., Xuei X., et al. Variations in GABRA2, encoding the alpha 2 subunit of the GABA(A) receptor, are associated with alcohol dependence and with brain oscillations. Am J Hum Genet: 2004; 74 4 705 714
    • (2004) Am J Hum Genet , vol.74 , Issue.4 , pp. 705-714
    • Edenberg, H.J.1    Dick, D.M.2    Xuei, X.3
  • 56
    • 33645563493 scopus 로고    scopus 로고
    • Association of GABRA2 with drug dependence in the collaborative study of the genetics of alcoholism sample
    • Agrawal A., Edenberg H. J., Foroud T., et al. Association of GABRA2 with drug dependence in the collaborative study of the genetics of alcoholism sample. Behav Genet: 2006; 36 5 640 650
    • (2006) Behav Genet , vol.36 , Issue.5 , pp. 640-650
    • Agrawal, A.1    Edenberg, H.J.2    Foroud, T.3
  • 58
    • 20244368365 scopus 로고    scopus 로고
    • Association between alcoholism and gamma-amino butyric acid alpha2 receptor subtype in a Russian population
    • Lappalainen J., Krupitsky E., Remizov M., et al. Association between alcoholism and gamma-amino butyric acid alpha2 receptor subtype in a Russian population. Alcohol Clin Exp Res: 2005; 29 4 493 498
    • (2005) Alcohol Clin Exp Res , vol.29 , Issue.4 , pp. 493-498
    • Lappalainen, J.1    Krupitsky, E.2    Remizov, M.3
  • 59
    • 33646708528 scopus 로고    scopus 로고
    • Confirmation of association of the GABRA2 gene with alcohol dependence by subtype-specific analysis
    • Fehr C., Sander T., Tadic A., et al. Confirmation of association of the GABRA2 gene with alcohol dependence by subtype-specific analysis. Psychiatr Genet: 2006; 16 1 9 17
    • (2006) Psychiatr Genet , vol.16 , Issue.1 , pp. 9-17
    • Fehr, C.1    Sander, T.2    Tadic, A.3
  • 60
    • 35349010056 scopus 로고    scopus 로고
    • Variation in GABRA2 predicts drinking behavior in project MATCH subjects
    • Bauer L. O., Covault J., Harel O., et al. Variation in GABRA2 predicts drinking behavior in project MATCH subjects. Alcohol Clin Exp Res: 2007; 31 11 1780 1787
    • (2007) Alcohol Clin Exp Res , vol.31 , Issue.11 , pp. 1780-1787
    • Bauer, L.O.1    Covault, J.2    Harel, O.3
  • 61
    • 19344363149 scopus 로고    scopus 로고
    • GABRA2 alleles moderate the subjective effects of alcohol, which are attenuated by finasteride
    • Pierucci-Lagha A., Covault J., Feinn R., et al. GABRA2 alleles moderate the subjective effects of alcohol, which are attenuated by finasteride. Neuropsychopharmacology: 2005; 30 6 1193 1203
    • (2005) Neuropsychopharmacology , vol.30 , Issue.6 , pp. 1193-1203
    • Pierucci-Lagha, A.1    Covault, J.2    Feinn, R.3
  • 62
    • 0345713190 scopus 로고    scopus 로고
    • Human chromosomes 11p15 and 4p12 and alcohol dependence: Possible association with the GABRB1 gene
    • Parsian A., Zhang Z. H. Human chromosomes 11p15 and 4p12 and alcohol dependence: possible association with the GABRB1 gene. Am J Med Genet: 1999; 88 5 533 538
    • (1999) Am J Med Genet , vol.88 , Issue.5 , pp. 533-538
    • Parsian, A.1    Zhang, Z.H.2
  • 63
    • 0037684038 scopus 로고    scopus 로고
    • Association of GABA(A) receptors and alcohol dependence and the effects of genetic imprinting
    • Song J., Koller D. L., Foroud T., et al. Association of GABA(A) receptors and alcohol dependence and the effects of genetic imprinting. Am J Med Genet B Neuropsychiatr Genet: 2003; 117B 1 39 45
    • (2003) Am J Med Genet B Neuropsychiatr Genet , vol.117 B , Issue.1 , pp. 39-45
    • Song, J.1    Koller, D.L.2    Foroud, T.3
  • 64
    • 79955662097 scopus 로고    scopus 로고
    • Linkage of GABRB1 to alcoholism and low voltage ALPHA EEG in two independent populations
    • Enoch M. A., Schwartz L. S., White K. V., et al. Linkage of GABRB1 to alcoholism and low voltage ALPHA EEG in two independent populations. Alcohol Clin Exp Res: 2005; 29 5 132a
    • (2005) Alcohol Clin Exp Res , vol.29 , Issue.5 , pp. 132a
    • Enoch, M.A.1    Schwartz, L.S.2    White, K.V.3
  • 65
    • 33645581349 scopus 로고    scopus 로고
    • The genetics of alcohol dependence
    • Dick D. M., Bierut L. J. The genetics of alcohol dependence. Curr Psychiatry Rep: 2006; 8 2 151 157
    • (2006) Curr Psychiatry Rep , vol.8 , Issue.2 , pp. 151-157
    • Dick, D.M.1    Bierut, L.J.2
  • 67
    • 0031456078 scopus 로고    scopus 로고
    • Alcohol dehydrogenase-2∗3 allele protects against alcohol-related birth defects among African Americans
    • McCarver D. G., Thomasson H. R., Martier S. S., Sokol R. J., Li T. Alcohol dehydrogenase-2∗3 allele protects against alcohol-related birth defects among African Americans. J Pharmacol Exp Ther: 1997; 283 3 1095 1101
    • (1997) J Pharmacol Exp Ther , vol.283 , Issue.3 , pp. 1095-1101
    • McCarver, D.G.1    Thomasson, H.R.2    Martier, S.S.3    Sokol, R.J.4    Li, T.5
  • 68
    • 36849038927 scopus 로고    scopus 로고
    • Approach to the genetics of alcoholism: A review based on pathophysiology
    • Köhnke M. D. Approach to the genetics of alcoholism: a review based on pathophysiology. Biochem Pharmacol: 2008; 75 1 160 177
    • (2008) Biochem Pharmacol , vol.75 , Issue.1 , pp. 160-177
    • Köhnke, M.D.1
  • 69
    • 33644499201 scopus 로고    scopus 로고
    • Do alcohol-metabolizing enzyme gene polymorphisms increase the risk of alcoholism and alcoholic liver disease?
    • Zintzaras E., Stefanidis I., Santos M., Vidal F. Do alcohol-metabolizing enzyme gene polymorphisms increase the risk of alcoholism and alcoholic liver disease? Hepatology: 2006; 43 2 352 361
    • (2006) Hepatology , vol.43 , Issue.2 , pp. 352-361
    • Zintzaras, E.1    Stefanidis, I.2    Santos, M.3    Vidal, F.4
  • 70
    • 1342267138 scopus 로고
    • Possible protective role against alcoholism for aldehyde dehydrogenase isozyme deficiency in Japan
    • Harada S., Agarwal D. P., Goedde H. W., Tagaki S., Ishikawa B. Possible protective role against alcoholism for aldehyde dehydrogenase isozyme deficiency in Japan. Lancet: 1982; 2 8302 827
    • (1982) Lancet , vol.2 , Issue.8302 , pp. 827
    • Harada, S.1    Agarwal, D.P.2    Goedde, H.W.3    Tagaki, S.4    Ishikawa, B.5
  • 71
    • 0034965118 scopus 로고    scopus 로고
    • Sex difference in alcohol-related organ injury
    • (5, Suppl ISBRA)
    • Sato N., Lindros K. O., Baraona E., et al. Sex difference in alcohol-related organ injury. Alcohol Clin Exp Res: 2001; 25 (5, Suppl ISBRA) 40S 45S
    • (2001) Alcohol Clin Exp Res , vol.25 , pp. 40S-45S
    • Sato, N.1    Lindros, K.O.2    Baraona, E.3
  • 72
    • 0034864068 scopus 로고    scopus 로고
    • The critical dimension of ethnicity in liver cirrhosis mortality statistics
    • Stinson F. S., Grant B. F., Dufour M. C. The critical dimension of ethnicity in liver cirrhosis mortality statistics. Alcohol Clin Exp Res: 2001; 25 8 1181 1187
    • (2001) Alcohol Clin Exp Res , vol.25 , Issue.8 , pp. 1181-1187
    • Stinson, F.S.1    Grant, B.F.2    Dufour, M.C.3
  • 73
    • 0030466376 scopus 로고    scopus 로고
    • Genetic predisposition to organ-specific endpoints of alcoholism
    • Reed T., Page W. F., Viken R. J., Christian J. C. Genetic predisposition to organ-specific endpoints of alcoholism. Alcohol Clin Exp Res: 1996; 20 9 1528 1533
    • (1996) Alcohol Clin Exp Res , vol.20 , Issue.9 , pp. 1528-1533
    • Reed, T.1    Page, W.F.2    Viken, R.J.3    Christian, J.C.4
  • 74
    • 0019515015 scopus 로고
    • Evidence of genetic predisposition to alcoholic cirrhosis and psychosis: Twin concordances for alcoholism and its biological end points by zygosity among male veterans
    • Hrubec Z., Omenn G. S. Evidence of genetic predisposition to alcoholic cirrhosis and psychosis: twin concordances for alcoholism and its biological end points by zygosity among male veterans. Alcohol Clin Exp Res: 1981; 5 2 207 215
    • (1981) Alcohol Clin Exp Res , vol.5 , Issue.2 , pp. 207-215
    • Hrubec, Z.1    Omenn, G.S.2
  • 75
    • 56749096610 scopus 로고    scopus 로고
    • Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease
    • Romeo S., Kozlitina J., Xing C., et al. Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease. Nat Genet: 2008; 40 12 1461 1465
    • (2008) Nat Genet , vol.40 , Issue.12 , pp. 1461-1465
    • Romeo, S.1    Kozlitina, J.2    Xing, C.3
  • 76
    • 69249111667 scopus 로고    scopus 로고
    • A nonsynonymous gene variant in the adiponutrin gene is associated with nonalcoholic fatty liver disease severity
    • Sookoian S., Castaño G. O., Burgueño A. L., Gianotti T. F., Rosselli M. S., Pirola C. J. A nonsynonymous gene variant in the adiponutrin gene is associated with nonalcoholic fatty liver disease severity. J Lipid Res: 2009; 50 10 2111 2116
    • (2009) J Lipid Res , vol.50 , Issue.10 , pp. 2111-2116
    • Sookoian, S.1    Castaño, G.O.2    Burgueño, A.L.3    Gianotti, T.F.4    Rosselli, M.S.5    Pirola, C.J.6
  • 77
    • 77956636268 scopus 로고    scopus 로고
    • The association of genetic variability in patatin-like phospholipase domain-containing protein 3 (PNPLA3) with histological severity of nonalcoholic fatty liver disease
    • NASH CRN.
    • Rotman Y., Koh C., Zmuda J. M., Kleiner D. E., Liang T. J.; NASH CRN. The association of genetic variability in patatin-like phospholipase domain-containing protein 3 (PNPLA3) with histological severity of nonalcoholic fatty liver disease. Hepatology: 2010; 52 3 894 903
    • (2010) Hepatology , vol.52 , Issue.3 , pp. 894-903
    • Rotman, Y.1    Koh, C.2    Zmuda, J.M.3    Kleiner, D.E.4    Liang, T.J.5
  • 78
    • 77950607738 scopus 로고    scopus 로고
    • Homozygosity for the patatin-like phospholipase-3/adiponutrin I148M polymorphism influences liver fibrosis in patients with nonalcoholic fatty liver disease
    • Valenti L., Al-Serri A., Daly A. K., et al. Homozygosity for the patatin-like phospholipase-3/adiponutrin I148M polymorphism influences liver fibrosis in patients with nonalcoholic fatty liver disease. Hepatology: 2010; 51 4 1209 1217
    • (2010) Hepatology , vol.51 , Issue.4 , pp. 1209-1217
    • Valenti, L.1    Al-Serri, A.2    Daly, A.K.3
  • 79
    • 84895792814 scopus 로고    scopus 로고
    • The effect of PNPLA3 on fibrosis progression and development of hepatocellular carcinoma: A meta-analysis
    • Singal A. G., Manjunath H., Yopp A. C., et al. The effect of PNPLA3 on fibrosis progression and development of hepatocellular carcinoma: a meta-analysis. Am J Gastroenterol: 2014; 109 3 325 334
    • (2014) Am J Gastroenterol , vol.109 , Issue.3 , pp. 325-334
    • Singal, A.G.1    Manjunath, H.2    Yopp, A.C.3
  • 80
    • 84902688337 scopus 로고    scopus 로고
    • Carriage of the PNPLA3 rs738409 C >g polymorphism confers an increased risk of non-alcoholic fatty liver disease associated hepatocellular carcinoma
    • Liu Y. L., Patman G. L., Leathart J. B., et al. Carriage of the PNPLA3 rs738409 C >G polymorphism confers an increased risk of non-alcoholic fatty liver disease associated hepatocellular carcinoma. J Hepatol: 2014; 61 1 75 81
    • (2014) J Hepatol , vol.61 , Issue.1 , pp. 75-81
    • Liu, Y.L.1    Patman, G.L.2    Leathart, J.B.3
  • 82
    • 84930766891 scopus 로고    scopus 로고
    • PNPLA3 gene polymorphism is associated with predisposition to and severity of alcoholic liver disease
    • Salameh H., Raff E., Erwin A., et al. PNPLA3 gene polymorphism is associated with predisposition to and severity of alcoholic liver disease. Am J Gastroenterol: 2015; 110 6 846 856
    • (2015) Am J Gastroenterol , vol.110 , Issue.6 , pp. 846-856
    • Salameh, H.1    Raff, E.2    Erwin, A.3
  • 83
    • 77952352488 scopus 로고    scopus 로고
    • Unravelling the pathogenesis of fatty liver disease: Patatin-like phospholipase domain-containing 3 protein
    • Romeo S., Huang-Doran I., Baroni M. G., Kotronen A. Unravelling the pathogenesis of fatty liver disease: patatin-like phospholipase domain-containing 3 protein. Curr Opin Lipidol: 2010; 21 3 247 252
    • (2010) Curr Opin Lipidol , vol.21 , Issue.3 , pp. 247-252
    • Romeo, S.1    Huang-Doran, I.2    Baroni, M.G.3    Kotronen, A.4
  • 84
    • 8844226709 scopus 로고    scopus 로고
    • Fat mobilization in adipose tissue is promoted by adipose triglyceride lipase
    • Zimmermann R., Strauss J. G., Haemmerle G., et al. Fat mobilization in adipose tissue is promoted by adipose triglyceride lipase. Science: 2004; 306 5700 1383 1386
    • (2004) Science , vol.306 , Issue.5700 , pp. 1383-1386
    • Zimmermann, R.1    Strauss, J.G.2    Haemmerle, G.3
  • 85
    • 0037984885 scopus 로고    scopus 로고
    • The crystal structure, mutagenesis, and activity studies reveal that patatin is a lipid acyl hydrolase with a Ser-Asp catalytic dyad
    • Rydel T. J., Williams J. M., Krieger E., et al. The crystal structure, mutagenesis, and activity studies reveal that patatin is a lipid acyl hydrolase with a Ser-Asp catalytic dyad. Biochemistry: 2003; 42 22 6696 6708
    • (2003) Biochemistry , vol.42 , Issue.22 , pp. 6696-6708
    • Rydel, T.J.1    Williams, J.M.2    Krieger, E.3
  • 86
    • 77949895032 scopus 로고    scopus 로고
    • A sequence variation (I148M) in PNPLA3 associated with nonalcoholic fatty liver disease disrupts triglyceride hydrolysis
    • He S., McPhaul C., Li J. Z., et al. A sequence variation (I148M) in PNPLA3 associated with nonalcoholic fatty liver disease disrupts triglyceride hydrolysis. J Biol Chem: 2010; 285 9 6706 6715
    • (2010) J Biol Chem , vol.285 , Issue.9 , pp. 6706-6715
    • He, S.1    McPhaul, C.2    Li, J.Z.3
  • 87
    • 79953745343 scopus 로고    scopus 로고
    • Genome-wide association analysis identifies variants associated with nonalcoholic fatty liver disease that have distinct effects on metabolic traits
    • NASH CRN; GIANT Consortium; MAGIC Investigators; GOLD Consortium.
    • Speliotes E. K., Yerges-Armstrong L. M., Wu J., et al. NASH CRN; GIANT Consortium; MAGIC Investigators; GOLD Consortium. Genome-wide association analysis identifies variants associated with nonalcoholic fatty liver disease that have distinct effects on metabolic traits. PLoS Genet: 2011; 7 3 e1001324
    • (2011) PLoS Genet , vol.7 , Issue.3 , pp. e1001324
    • Speliotes, E.K.1    Yerges-Armstrong, L.M.2    Wu, J.3
  • 88
    • 84898058711 scopus 로고    scopus 로고
    • Exome-wide association study identifies a TM6SF2 variant that confers susceptibility to nonalcoholic fatty liver disease
    • Kozlitina J., Smagris E., Stender S., et al. Exome-wide association study identifies a TM6SF2 variant that confers susceptibility to nonalcoholic fatty liver disease. Nat Genet: 2014; 46 4 352 356
    • (2014) Nat Genet , vol.46 , Issue.4 , pp. 352-356
    • Kozlitina, J.1    Smagris, E.2    Stender, S.3
  • 89
    • 84903708160 scopus 로고    scopus 로고
    • TM6SF2 rs58542926 influences hepatic fibrosis progression in patients with non-alcoholic fatty liver disease
    • Liu Y. L., Reeves H. L., Burt A. D., et al. TM6SF2 rs58542926 influences hepatic fibrosis progression in patients with non-alcoholic fatty liver disease. Nat Commun: 2014; 5 4309
    • (2014) Nat Commun , vol.5 , pp. 4309
    • Liu, Y.L.1    Reeves, H.L.2    Burt, A.D.3
  • 90
    • 84921487729 scopus 로고    scopus 로고
    • Transmembrane 6 superfamily member 2 gene variant disentangles nonalcoholic steatohepatitis from cardiovascular disease
    • Dongiovanni P., Petta S., Maglio C., et al. Transmembrane 6 superfamily member 2 gene variant disentangles nonalcoholic steatohepatitis from cardiovascular disease. Hepatology: 2015; 61 2 506 514
    • (2015) Hepatology , vol.61 , Issue.2 , pp. 506-514
    • Dongiovanni, P.1    Petta, S.2    Maglio, C.3
  • 91
    • 84949974197 scopus 로고    scopus 로고
    • A functional variant in TM6SF2 associates with alcohol related cirrhosis risk in a British and Irish population
    • Way M., Atkinson S., McQuillin A., et al. A functional variant in TM6SF2 associates with alcohol related cirrhosis risk in a British and Irish population. J Hepatol: 2015; 62 S772
    • (2015) J Hepatol , vol.62 , pp. S772
    • Way, M.1    Atkinson, S.2    McQuillin, A.3
  • 92
    • 38349078988 scopus 로고    scopus 로고
    • Common pathogenic mechanism in development progression of liver injury caused by non-alcoholic or alcoholic steatohepatitis
    • Nagata K., Suzuki H., Sakaguchi S. Common pathogenic mechanism in development progression of liver injury caused by non-alcoholic or alcoholic steatohepatitis. J Toxicol Sci: 2007; 32 5 453 468
    • (2007) J Toxicol Sci , vol.32 , Issue.5 , pp. 453-468
    • Nagata, K.1    Suzuki, H.2    Sakaguchi, S.3
  • 93
    • 67649968443 scopus 로고    scopus 로고
    • Oxidative stress and alcoholic liver disease
    • Wu D., Cederbaum A. I. Oxidative stress and alcoholic liver disease. Semin Liver Dis: 2009; 29 2 141 154
    • (2009) Semin Liver Dis , vol.29 , Issue.2 , pp. 141-154
    • Wu, D.1    Cederbaum, A.I.2
  • 94
    • 67349255858 scopus 로고    scopus 로고
    • Signalling pathways in alcohol-induced liver inflammation
    • Mandrekar P., Szabo G. Signalling pathways in alcohol-induced liver inflammation. J Hepatol: 2009; 50 6 1258 1266
    • (2009) J Hepatol , vol.50 , Issue.6 , pp. 1258-1266
    • Mandrekar, P.1    Szabo, G.2
  • 95
    • 33644524120 scopus 로고    scopus 로고
    • Apoptosis and necrosis in the liver: A tale of two deaths?
    • 01
    • Malhi H., Gores G. J., Lemasters J. J. Apoptosis and necrosis in the liver: a tale of two deaths? Hepatology: 2006; 43 2 01 S31 S44
    • (2006) Hepatology , vol.43 , Issue.2 , pp. S31-S44
    • Malhi, H.1    Gores, G.J.2    Lemasters, J.J.3
  • 96
    • 77955852465 scopus 로고    scopus 로고
    • Impact of pan-caspase inhibition in animal models of established steatosis and non-alcoholic steatohepatitis
    • Anstee Q. M., Concas D., Kudo H., et al. Impact of pan-caspase inhibition in animal models of established steatosis and non-alcoholic steatohepatitis. J Hepatol: 2010; 53 3 542 550
    • (2010) J Hepatol , vol.53 , Issue.3 , pp. 542-550
    • Anstee, Q.M.1    Concas, D.2    Kudo, H.3
  • 97
    • 63049134573 scopus 로고    scopus 로고
    • Apoptosis in experimental NASH is associated with p53 activation and TRAIL receptor expression
    • Farrell G. C., Larter C. Z., Hou J. Y., et al. Apoptosis in experimental NASH is associated with p53 activation and TRAIL receptor expression. J Gastroenterol Hepatol: 2009; 24 3 443 452
    • (2009) J Gastroenterol Hepatol , vol.24 , Issue.3 , pp. 443-452
    • Farrell, G.C.1    Larter, C.Z.2    Hou, J.Y.3
  • 98
    • 33847363203 scopus 로고    scopus 로고
    • Models of liver fibrosis: Exploring the dynamic nature of inflammation and repair in a solid organ
    • Iredale J. P. Models of liver fibrosis: exploring the dynamic nature of inflammation and repair in a solid organ. J Clin Invest: 2007; 117 3 539 548
    • (2007) J Clin Invest , vol.117 , Issue.3 , pp. 539-548
    • Iredale, J.P.1
  • 99
    • 84872410210 scopus 로고    scopus 로고
    • Roles of cytochrome P4502E1 gene polymorphisms and the risks of alcoholic liver disease: A meta-analysis
    • Zeng T., Guo F. F., Zhang C. L., Song F. Y., Zhao X. L., Xie K. Q. Roles of cytochrome P4502E1 gene polymorphisms and the risks of alcoholic liver disease: a meta-analysis. PLoS ONE: 2013; 8 1 e54188
    • (2013) PLoS ONE , vol.8 , Issue.1 , pp. e54188
    • Zeng, T.1    Guo, F.F.2    Zhang, C.L.3    Song, F.Y.4    Zhao, X.L.5    Xie, K.Q.6
  • 100
    • 0031820034 scopus 로고    scopus 로고
    • Heterozygotes for HFE mutations have no increased risk of advanced alcoholic liver disease
    • Grove J., Daly A. K., Burt A. D., et al. Heterozygotes for HFE mutations have no increased risk of advanced alcoholic liver disease. Gut: 1998; 43 2 262 266
    • (1998) Gut , vol.43 , Issue.2 , pp. 262-266
    • Grove, J.1    Daly, A.K.2    Burt, A.D.3
  • 101
    • 33644930840 scopus 로고    scopus 로고
    • HFE genotypes in decompensated alcoholic liver disease: Phenotypic expression and comparison with heavy drinking and with normal controls
    • Gleeson D., Evans S., Bradley M., et al. HFE genotypes in decompensated alcoholic liver disease: phenotypic expression and comparison with heavy drinking and with normal controls. Am J Gastroenterol: 2006; 101 2 304 310
    • (2006) Am J Gastroenterol , vol.101 , Issue.2 , pp. 304-310
    • Gleeson, D.1    Evans, S.2    Bradley, M.3
  • 102
    • 0035062753 scopus 로고    scopus 로고
    • Invited review: Manganese superoxide dismutase in disease
    • Macmillan-Crow L. A., Cruthirds D. L. Invited review: manganese superoxide dismutase in disease. Free Radic Res: 2001; 34 4 325 336
    • (2001) Free Radic Res , vol.34 , Issue.4 , pp. 325-336
    • MacMillan-Crow, L.A.1    Cruthirds, D.L.2
  • 103
    • 0030582372 scopus 로고    scopus 로고
    • Structural dimorphism in the mitochondrial targeting sequence in the human manganese superoxide dismutase gene. A predictive evidence for conformational change to influence mitochondrial transport and a study of allelic association in Parkinson's disease
    • Shimoda-Matsubayashi S., Matsumine H., Kobayashi T., Nakagawa-Hattori Y., Shimizu Y., Mizuno Y. Structural dimorphism in the mitochondrial targeting sequence in the human manganese superoxide dismutase gene. A predictive evidence for conformational change to influence mitochondrial transport and a study of allelic association in Parkinson's disease. Biochem Biophys Res Commun: 1996; 226 2 561 565
    • (1996) Biochem Biophys Res Commun , vol.226 , Issue.2 , pp. 561-565
    • Shimoda-Matsubayashi, S.1    Matsumine, H.2    Kobayashi, T.3    Nakagawa-Hattori, Y.4    Shimizu, Y.5    Mizuno, Y.6
  • 104
    • 18744396930 scopus 로고    scopus 로고
    • The manganese superoxide dismutase Ala16Val dimorphism modulates both mitochondrial import and mRNA stability
    • Sutton A., Imbert A., Igoudjil A., et al. The manganese superoxide dismutase Ala16Val dimorphism modulates both mitochondrial import and mRNA stability. Pharmacogenet Genomics: 2005; 15 5 311 319
    • (2005) Pharmacogenet Genomics , vol.15 , Issue.5 , pp. 311-319
    • Sutton, A.1    Imbert, A.2    Igoudjil, A.3
  • 105
    • 0037339203 scopus 로고    scopus 로고
    • The Ala16Val genetic dimorphism modulates the import of human manganese superoxide dismutase into rat liver mitochondria
    • Sutton A., Khoury H., Prip-Buus C., Cepanec C., Pessayre D., Degoul F. The Ala16Val genetic dimorphism modulates the import of human manganese superoxide dismutase into rat liver mitochondria. Pharmacogenetics: 2003; 13 3 145 157
    • (2003) Pharmacogenetics , vol.13 , Issue.3 , pp. 145-157
    • Sutton, A.1    Khoury, H.2    Prip-Buus, C.3    Cepanec, C.4    Pessayre, D.5    Degoul, F.6
  • 106
    • 11144356355 scopus 로고    scopus 로고
    • Polymorphisms of microsomal triglyceride transfer protein gene and manganese superoxide dismutase gene in non-alcoholic steatohepatitis
    • Namikawa C., Shu-Ping Z., Vyselaar J. R., et al. Polymorphisms of microsomal triglyceride transfer protein gene and manganese superoxide dismutase gene in non-alcoholic steatohepatitis. J Hepatol: 2004; 40 5 781 786
    • (2004) J Hepatol , vol.40 , Issue.5 , pp. 781-786
    • Namikawa, C.1    Shu-Ping, Z.2    Vyselaar, J.R.3
  • 107
    • 84855978332 scopus 로고    scopus 로고
    • The SOD2 C47T polymorphism influences NAFLD fibrosis severity: Evidence from case-control and intra-familial allele association studies
    • Al-Serri A., Anstee Q. M., Valenti L., et al. The SOD2 C47T polymorphism influences NAFLD fibrosis severity: evidence from case-control and intra-familial allele association studies. J Hepatol: 2011; 56 2 448 454
    • (2011) J Hepatol , vol.56 , Issue.2 , pp. 448-454
    • Al-Serri, A.1    Anstee, Q.M.2    Valenti, L.3
  • 108
    • 0035045720 scopus 로고    scopus 로고
    • Homozygosity for alanine in the mitochondrial targeting sequence of superoxide dismutase and risk for severe alcoholic liver disease
    • Degoul F., Sutton A., Mansouri A., et al. Homozygosity for alanine in the mitochondrial targeting sequence of superoxide dismutase and risk for severe alcoholic liver disease. Gastroenterology: 2001; 120 6 1468 1474
    • (2001) Gastroenterology , vol.120 , Issue.6 , pp. 1468-1474
    • Degoul, F.1    Sutton, A.2    Mansouri, A.3
  • 109
    • 0036894470 scopus 로고    scopus 로고
    • Valine-alanine manganese superoxide dismutase polymorphism is not associated with alcohol-induced oxidative stress or liver fibrosis
    • Stewart S. F., Leathart J. B., Chen Y., et al. Valine-alanine manganese superoxide dismutase polymorphism is not associated with alcohol-induced oxidative stress or liver fibrosis. Hepatology: 2002; 36 6 1355 1360
    • (2002) Hepatology , vol.36 , Issue.6 , pp. 1355-1360
    • Stewart, S.F.1    Leathart, J.B.2    Chen, Y.3
  • 110
    • 26444453224 scopus 로고    scopus 로고
    • Are genetic polymorphisms of tumour necrosis factor alpha, interleukin-10, CD14 endotoxin receptor or manganese superoxide dismutase associated with alcoholic liver disease?
    • Martins A., Cortez-Pinto H., Machado M., et al. Are genetic polymorphisms of tumour necrosis factor alpha, interleukin-10, CD14 endotoxin receptor or manganese superoxide dismutase associated with alcoholic liver disease? Eur J Gastroenterol Hepatol: 2005; 17 10 1099 1104
    • (2005) Eur J Gastroenterol Hepatol , vol.17 , Issue.10 , pp. 1099-1104
    • Martins, A.1    Cortez-Pinto, H.2    MacHado, M.3
  • 111
    • 72949083509 scopus 로고    scopus 로고
    • Myeloperoxidase and superoxide dismutase 2 polymorphisms comodulate the risk of hepatocellular carcinoma and death in alcoholic cirrhosis
    • Nahon P., Sutton A., Rufat P., et al. Myeloperoxidase and superoxide dismutase 2 polymorphisms comodulate the risk of hepatocellular carcinoma and death in alcoholic cirrhosis. Hepatology: 2009; 50 5 1484 1493
    • (2009) Hepatology , vol.50 , Issue.5 , pp. 1484-1493
    • Nahon, P.1    Sutton, A.2    Rufat, P.3
  • 112
    • 34547546458 scopus 로고    scopus 로고
    • A genome-wide association scan identifies the hepatic cholesterol transporter ABCG8 as a susceptibility factor for human gallstone disease
    • Buch S., Schafmayer C., Völzke H., et al. A genome-wide association scan identifies the hepatic cholesterol transporter ABCG8 as a susceptibility factor for human gallstone disease. Nat Genet: 2007; 39 8 995 999
    • (2007) Nat Genet , vol.39 , Issue.8 , pp. 995-999
    • Buch, S.1    Schafmayer, C.2    Völzke, H.3
  • 113
    • 16444381643 scopus 로고    scopus 로고
    • Polymorphisms of the glutathione S-transferases mu-1 (GSTM1) and theta-1 (GSTT1) and the risk of advanced alcoholic liver disease
    • Ladero J. M., Martínez C., García-Martin E., et al. Polymorphisms of the glutathione S-transferases mu-1 (GSTM1) and theta-1 (GSTT1) and the risk of advanced alcoholic liver disease. Scand J Gastroenterol: 2005; 40 3 348 353
    • (2005) Scand J Gastroenterol , vol.40 , Issue.3 , pp. 348-353
    • Ladero, J.M.1    Martínez, C.2    García-Martin, E.3
  • 114
    • 8844285231 scopus 로고    scopus 로고
    • The role of polymorphisms of glutathione S-transferases GSTM1, M3, P1, T1 and A1 in susceptibility to alcoholic liver disease
    • Brind A. M., Hurlstone A., Edrisinghe D., et al. The role of polymorphisms of glutathione S-transferases GSTM1, M3, P1, T1 and A1 in susceptibility to alcoholic liver disease. Alcohol Alcohol: 2004; 39 6 478 483
    • (2004) Alcohol Alcohol , vol.39 , Issue.6 , pp. 478-483
    • Brind, A.M.1    Hurlstone, A.2    Edrisinghe, D.3
  • 115
    • 0032519517 scopus 로고    scopus 로고
    • Human glutathione transferase A4-4: An alpha class enzyme with high catalytic efficiency in the conjugation of 4-hydroxynonenal and other genotoxic products of lipid peroxidation
    • (Pt 1)
    • Hubatsch I., Ridderström M., Mannervik B. Human glutathione transferase A4-4: an alpha class enzyme with high catalytic efficiency in the conjugation of 4-hydroxynonenal and other genotoxic products of lipid peroxidation. Biochem J: 1998; 330 (Pt 1): 175 179
    • (1998) Biochem J , vol.330 , pp. 175-179
    • Hubatsch, I.1    Ridderström, M.2    Mannervik, B.3
  • 116
    • 84941918492 scopus 로고    scopus 로고
    • The gut microbiota and non-alcoholic fatty liver disease
    • Quigley E. M., Monsour H. P. The gut microbiota and non-alcoholic fatty liver disease. Semin Liver Dis: 2015; 35 3 262 269
    • (2015) Semin Liver Dis , vol.35 , Issue.3 , pp. 262-269
    • Quigley, E.M.1    Monsour, H.P.2
  • 117
    • 0033129061 scopus 로고    scopus 로고
    • A Polymorphism∗ in the 5′ flanking region of the CD14 gene is associated with circulating soluble CD14 levels and with total serum immunoglobulin E
    • Baldini M., Lohman I. C., Halonen M., Erickson R. P., Holt P. G., Martinez F. D. A Polymorphism∗ in the 5′ flanking region of the CD14 gene is associated with circulating soluble CD14 levels and with total serum immunoglobulin E. Am J Respir Cell Mol Biol: 1999; 20 5 976 983
    • (1999) Am J Respir Cell Mol Biol , vol.20 , Issue.5 , pp. 976-983
    • Baldini, M.1    Lohman, I.C.2    Halonen, M.3    Erickson, R.P.4    Holt, P.G.5    Martinez, F.D.6
  • 118
    • 0035041058 scopus 로고    scopus 로고
    • Promoter polymorphism of the CD14 endotoxin receptor gene as a risk factor for alcoholic liver disease
    • Järveläinen H. A., Orpana A., Perola M., Savolainen V. T., Karhunen P. J., Lindros K. O. Promoter polymorphism of the CD14 endotoxin receptor gene as a risk factor for alcoholic liver disease. Hepatology: 2001; 33 5 1148 1153
    • (2001) Hepatology , vol.33 , Issue.5 , pp. 1148-1153
    • Järveläinen, H.A.1    Orpana, A.2    Perola, M.3    Savolainen, V.T.4    Karhunen, P.J.5    Lindros, K.O.6
  • 119
    • 23044497409 scopus 로고    scopus 로고
    • The -159C/T polymorphism in the promoter region of the CD14 gene is associated with advanced liver disease and higher serum levels of acute-phase proteins in heavy drinkers
    • Campos J., Gonzalez-Quintela A., Quinteiro C., et al. The -159C/T polymorphism in the promoter region of the CD14 gene is associated with advanced liver disease and higher serum levels of acute-phase proteins in heavy drinkers. Alcohol Clin Exp Res: 2005; 29 7 1206 1213
    • (2005) Alcohol Clin Exp Res , vol.29 , Issue.7 , pp. 1206-1213
    • Campos, J.1    Gonzalez-Quintela, A.2    Quinteiro, C.3
  • 120
    • 28644449170 scopus 로고    scopus 로고
    • Different effects of a CD14 gene polymorphism on disease outcome in patients with alcoholic liver disease and chronic hepatitis C infection
    • Meiler C., Muhlbauer M., Johann M., et al. Different effects of a CD14 gene polymorphism on disease outcome in patients with alcoholic liver disease and chronic hepatitis C infection. World J Gastroenterol: 2005; 11 38 6031 6037
    • (2005) World J Gastroenterol , vol.11 , Issue.38 , pp. 6031-6037
    • Meiler, C.1    Muhlbauer, M.2    Johann, M.3
  • 121
    • 33749622169 scopus 로고    scopus 로고
    • No association between functional SNPs in the endotoxin receptors CD14 and TLR4 and alcoholic liver disease (ALD): Is endotoxin important in the pathogenesis of aid in humans?
    • Leathart J. B., Day C. P., Daly A. K. No association between functional SNPs in the endotoxin receptors CD14 and TLR4 and alcoholic liver disease (ALD): Is endotoxin important in the pathogenesis of aid in humans? Hepatology: 2001; 34 459a
    • (2001) Hepatology , vol.34 , pp. 459a
    • Leathart, J.B.1    Day, C.P.2    Daly, A.K.3
  • 122
    • 0034084438 scopus 로고    scopus 로고
    • TLR4 mutations are associated with endotoxin hyporesponsiveness in humans
    • Arbour N. C., Lorenz E., Schutte B. C., et al. TLR4 mutations are associated with endotoxin hyporesponsiveness in humans. Nat Genet: 2000; 25 2 187 191
    • (2000) Nat Genet , vol.25 , Issue.2 , pp. 187-191
    • Arbour, N.C.1    Lorenz, E.2    Schutte, B.C.3
  • 123
    • 84883653695 scopus 로고    scopus 로고
    • Association between CD14-159C>T polymorphisms and the risk for alcoholic liver disease: A meta-analysis
    • Zeng T., Zhang C. L., Han X. Y., Zhao S., Xie K. Q. Association between CD14-159C>T polymorphisms and the risk for alcoholic liver disease: a meta-analysis. Eur J Gastroenterol Hepatol: 2013; 25 10 1183 1189
    • (2013) Eur J Gastroenterol Hepatol , vol.25 , Issue.10 , pp. 1183-1189
    • Zeng, T.1    Zhang, C.L.2    Han, X.Y.3    Zhao, S.4    Xie, K.Q.5
  • 124
    • 0034109157 scopus 로고    scopus 로고
    • Interleukin 10 promoter region polymorphisms and susceptibility to advanced alcoholic liver disease
    • Grove J., Daly A. K., Bassendine M. F., Gilvarry E., Day C. P. Interleukin 10 promoter region polymorphisms and susceptibility to advanced alcoholic liver disease. Gut: 2000; 46 4 540 545
    • (2000) Gut , vol.46 , Issue.4 , pp. 540-545
    • Grove, J.1    Daly, A.K.2    Bassendine, M.F.3    Gilvarry, E.4    Day, C.P.5
  • 125
    • 0036990311 scopus 로고    scopus 로고
    • Single-nucleotide polymorphisms in the interleukin-10 gene: Differences in frequencies, linkage disequilibrium patterns, and haplotypes in three United States ethnic groups
    • Lazarus R., Klimecki W. T., Palmer L. J., et al. Single-nucleotide polymorphisms in the interleukin-10 gene: differences in frequencies, linkage disequilibrium patterns, and haplotypes in three United States ethnic groups. Genomics: 2002; 80 2 223 228
    • (2002) Genomics , vol.80 , Issue.2 , pp. 223-228
    • Lazarus, R.1    Klimecki, W.T.2    Palmer, L.J.3
  • 126
    • 0035990950 scopus 로고    scopus 로고
    • Single nucleotide polymorphisms and microsatellite alleles of tumor necrosis factor alpha and interleukin-10 genes and the risk of advanced chronic alcoholic liver disease
    • Ladero J. M., Fernández-Arquero M., Tudela J. I., et al. Single nucleotide polymorphisms and microsatellite alleles of tumor necrosis factor alpha and interleukin-10 genes and the risk of advanced chronic alcoholic liver disease. Liver: 2002; 22 3 245 251
    • (2002) Liver , vol.22 , Issue.3 , pp. 245-251
    • Ladero, J.M.1    Fernández-Arquero, M.2    Tudela, J.I.3
  • 127
    • 84866149999 scopus 로고    scopus 로고
    • Genetic variants of TNFα, IL10, IL1β, CTLA4 and TGFβ1 modulate the indices of alcohol-induced liver injury in East Indian population
    • Roy N., Mukhopadhyay I., Das K., et al. Genetic variants of TNFα, IL10, IL1β, CTLA4 and TGFβ1 modulate the indices of alcohol-induced liver injury in East Indian population. Gene: 2012; 509 1 178 188
    • (2012) Gene , vol.509 , Issue.1 , pp. 178-188
    • Roy, N.1    Mukhopadhyay, I.2    Das, K.3
  • 128
    • 0034021933 scopus 로고    scopus 로고
    • Genetic polymorphisms of interleukin-1beta in association with the development of alcoholic liver disease in Japanese patients
    • Takamatsu M., Yamauchi M., Maezawa Y., Saito S., Maeyama S., Uchikoshi T. Genetic polymorphisms of interleukin-1beta in association with the development of alcoholic liver disease in Japanese patients. Am J Gastroenterol: 2000; 95 5 1305 1311
    • (2000) Am J Gastroenterol , vol.95 , Issue.5 , pp. 1305-1311
    • Takamatsu, M.1    Yamauchi, M.2    Maezawa, Y.3    Saito, S.4    Maeyama, S.5    Uchikoshi, T.6
  • 130
    • 0031009602 scopus 로고    scopus 로고
    • Association of a tumor necrosis factor promoter polymorphism with susceptibility to alcoholic steatohepatitis
    • Grove J., Daly A. K., Bassendine M. F., Day C. P. Association of a tumor necrosis factor promoter polymorphism with susceptibility to alcoholic steatohepatitis. Hepatology: 1997; 26 1 143 146
    • (1997) Hepatology , vol.26 , Issue.1 , pp. 143-146
    • Grove, J.1    Daly, A.K.2    Bassendine, M.F.3    Day, C.P.4
  • 131
    • 29044443442 scopus 로고    scopus 로고
    • -238 G>A polymorphism of tumor necrosis factor alpha gene (TNFA) is associated with alcoholic liver cirrhosis in alcoholic Spanish men
    • Pastor I. J., Laso F. J., Romero A., González-Sarmiento R. -238 G>A polymorphism of tumor necrosis factor alpha gene (TNFA) is associated with alcoholic liver cirrhosis in alcoholic Spanish men. Alcohol Clin Exp Res: 2005; 29 11 1928 1931
    • (2005) Alcohol Clin Exp Res , vol.29 , Issue.11 , pp. 1928-1931
    • Pastor, I.J.1    Laso, F.J.2    Romero, A.3    González-Sarmiento, R.4
  • 132
    • 33847008303 scopus 로고    scopus 로고
    • Genetics of alcoholic liver disease and nonalcoholic fatty liver disease
    • Wilfred de Alwis N. M., Day C. P. Genetics of alcoholic liver disease and nonalcoholic fatty liver disease. Semin Liver Dis: 2007; 27 1 44 54
    • (2007) Semin Liver Dis , vol.27 , Issue.1 , pp. 44-54
    • Wilfred De Alwis, N.M.1    Day, C.P.2
  • 133
    • 70349662172 scopus 로고    scopus 로고
    • Tumor necrosis factor polymorphisms and alcoholic liver disease: A HuGE review and meta-analysis
    • Marcos M., Gómez-Munuera M., Pastor I., González-Sarmiento R., Laso F. J. Tumor necrosis factor polymorphisms and alcoholic liver disease: a HuGE review and meta-analysis. Am J Epidemiol: 2009; 170 8 948 956
    • (2009) Am J Epidemiol , vol.170 , Issue.8 , pp. 948-956
    • Marcos, M.1    Gómez-Munuera, M.2    Pastor, I.3    González-Sarmiento, R.4    Laso, F.J.5
  • 134
    • 66149104271 scopus 로고    scopus 로고
    • Angiotensin II activates I kappaB kinase phosphorylation of RelA at ser 536 to promote myofibroblast survival and liver fibrosis
    • Oakley F., Teoh V., Ching-A-Sue G., et al. Angiotensin II activates I kappaB kinase phosphorylation of RelA at Ser 536 to promote myofibroblast survival and liver fibrosis. Gastroenterology: 2009; 136 7 2334 2344.e1
    • (2009) Gastroenterology , vol.136 , Issue.7 , pp. 2334-2344e1
    • Oakley, F.1    Teoh, V.2    Ching-A-Sue-A, G.3
  • 135
    • 70350517517 scopus 로고    scopus 로고
    • A functional polymorphism of the NFKB1 gene increases the risk for alcoholic liver cirrhosis in patients with alcohol dependence
    • Marcos M., Pastor I., González-Sarmiento R., Laso F. J. A functional polymorphism of the NFKB1 gene increases the risk for alcoholic liver cirrhosis in patients with alcohol dependence. Alcohol Clin Exp Res: 2009; 33 11 1857 1862
    • (2009) Alcohol Clin Exp Res , vol.33 , Issue.11 , pp. 1857-1862
    • Marcos, M.1    Pastor, I.2    González-Sarmiento, R.3    Laso, F.J.4
  • 136
    • 41149164581 scopus 로고    scopus 로고
    • Evaluation of the transforming growth factor beta1 codon 25 (Arg->Pro) polymorphism in alcoholic liver disease
    • Osterreicher C. H., Halangk J., Berg T., et al. Evaluation of the transforming growth factor beta1 codon 25 (Arg->Pro) polymorphism in alcoholic liver disease. Cytokine: 2008; 42 1 18 23
    • (2008) Cytokine , vol.42 , Issue.1 , pp. 18-23
    • Osterreicher, C.H.1    Halangk, J.2    Berg, T.3
  • 137
    • 44349132734 scopus 로고    scopus 로고
    • No role of matrixmetalloproteinase-3 genetic promoter polymorphism 1171 as a risk factor for cirrhosis in alcoholic liver disease
    • Stickel F., Osterreicher C. H., Halangk J., et al. No role of matrixmetalloproteinase-3 genetic promoter polymorphism 1171 as a risk factor for cirrhosis in alcoholic liver disease. Alcohol Clin Exp Res: 2008; 32 6 959 965
    • (2008) Alcohol Clin Exp Res , vol.32 , Issue.6 , pp. 959-965
    • Stickel, F.1    Osterreicher, C.H.2    Halangk, J.3
  • 138
    • 0027056745 scopus 로고
    • No evidence for involvement of type 1 collagen structural genes in 'genetic predisposition' to alcoholic cirrhosis
    • Bashir R., Day C. P., James O. F., Ogilvie D. J., Sykes B., Bassendine M. F. No evidence for involvement of type 1 collagen structural genes in 'genetic predisposition' to alcoholic cirrhosis. J Hepatol: 1992; 16 3 316 319
    • (1992) J Hepatol , vol.16 , Issue.3 , pp. 316-319
    • Bashir, R.1    Day, C.P.2    James, O.F.3    Ogilvie, D.J.4    Sykes, B.5    Bassendine, M.F.6
  • 139
    • 33645052709 scopus 로고    scopus 로고
    • Genetic polymorphisms in antioxidant enzymes modulate hepatic iron accumulation and hepatocellular carcinoma development in patients with alcohol-induced cirrhosis
    • Sutton A., Nahon P., Pessayre D., et al. Genetic polymorphisms in antioxidant enzymes modulate hepatic iron accumulation and hepatocellular carcinoma development in patients with alcohol-induced cirrhosis. Cancer Res: 2006; 66 5 2844 2852
    • (2006) Cancer Res , vol.66 , Issue.5 , pp. 2844-2852
    • Sutton, A.1    Nahon, P.2    Pessayre, D.3
  • 140
    • 20244365330 scopus 로고    scopus 로고
    • Genetic dimorphism in superoxide dismutase and susceptibility to alcoholic cirrhosis, hepatocellular carcinoma, and death
    • Nahon P., Sutton A., Pessayre D., et al. Genetic dimorphism in superoxide dismutase and susceptibility to alcoholic cirrhosis, hepatocellular carcinoma, and death. Clin Gastroenterol Hepatol: 2005; 3 3 292 298
    • (2005) Clin Gastroenterol Hepatol , vol.3 , Issue.3 , pp. 292-298
    • Nahon, P.1    Sutton, A.2    Pessayre, D.3
  • 141
    • 4344703254 scopus 로고    scopus 로고
    • The MTHFR 677C > T polymorphism is associated with an increased risk of hepatocellular carcinoma in patients with alcoholic cirrhosis
    • Saffroy R., Pham P., Chiappini F., et al. The MTHFR 677C > T polymorphism is associated with an increased risk of hepatocellular carcinoma in patients with alcoholic cirrhosis. Carcinogenesis: 2004; 25 8 1443 1448
    • (2004) Carcinogenesis , vol.25 , Issue.8 , pp. 1443-1448
    • Saffroy, R.1    Pham, P.2    Chiappini, F.3
  • 142
    • 84886308722 scopus 로고    scopus 로고
    • Genetic variation in the PNPLA3 gene and hepatocellular carcinoma in USA: Risk and prognosis prediction
    • 01
    • Hassan M. M., Kaseb A., Etzel C. J., et al. Genetic variation in the PNPLA3 gene and hepatocellular carcinoma in USA: risk and prognosis prediction. Mol Carcinog: 2013; 52 01 E139 E147
    • (2013) Mol Carcinog , vol.52 , pp. E139-E147
    • Hassan, M.M.1    Kaseb, A.2    Etzel, C.J.3
  • 143
    • 84868304332 scopus 로고    scopus 로고
    • PNPLA3 I148M (rs738409) genetic variant is associated with hepatocellular carcinoma in obese individuals
    • Burza M. A., Pirazzi C., Maglio C., et al. PNPLA3 I148M (rs738409) genetic variant is associated with hepatocellular carcinoma in obese individuals. Dig Liver Dis: 2012; 44 12 1037 1041
    • (2012) Dig Liver Dis , vol.44 , Issue.12 , pp. 1037-1041
    • Burza, M.A.1    Pirazzi, C.2    Maglio, C.3
  • 144
    • 84872421093 scopus 로고    scopus 로고
    • PNPLA3 rs738409, hepatocellular carcinoma occurrence and risk model prediction in patients with cirrhosis
    • Guyot E., Sutton A., Rufat P., et al. PNPLA3 rs738409, hepatocellular carcinoma occurrence and risk model prediction in patients with cirrhosis. J Hepatol: 2013; 58 2 312 318
    • (2013) J Hepatol , vol.58 , Issue.2 , pp. 312-318
    • Guyot, E.1    Sutton, A.2    Rufat, P.3
  • 145
    • 80455174482 scopus 로고    scopus 로고
    • The PNPLA3 rs738409 148M/M genotype is a risk factor for liver cancer in alcoholic cirrhosis but shows no or weak association in hepatitis C cirrhosis
    • Nischalke H. D., Berger C., Luda C., et al. The PNPLA3 rs738409 148M/M genotype is a risk factor for liver cancer in alcoholic cirrhosis but shows no or weak association in hepatitis C cirrhosis. PLoS ONE: 2011; 6 11 e27087
    • (2011) PLoS ONE , vol.6 , Issue.11 , pp. e27087
    • Nischalke, H.D.1    Berger, C.2    Luda, C.3
  • 146
    • 79952222716 scopus 로고    scopus 로고
    • Patatin-like phospholipase domain-containing 3 I148M polymorphism, steatosis, and liver damage in chronic hepatitis C
    • Valenti L., Rumi M., Galmozzi E., et al. Patatin-like phospholipase domain-containing 3 I148M polymorphism, steatosis, and liver damage in chronic hepatitis C. Hepatology: 2011; 53 3 791 799
    • (2011) Hepatology , vol.53 , Issue.3 , pp. 791-799
    • Valenti, L.1    Rumi, M.2    Galmozzi, E.3
  • 147
    • 79961186012 scopus 로고    scopus 로고
    • PNPLA3 rs738409C/G polymorphism in cirrhosis: Relationship with the aetiology of liver disease and hepatocellular carcinoma occurrence
    • Falleti E., Fabris C., Cmet S., et al. PNPLA3 rs738409C/G polymorphism in cirrhosis: relationship with the aetiology of liver disease and hepatocellular carcinoma occurrence. Liver Int: 2011; 31 8 1137 1143
    • (2011) Liver Int , vol.31 , Issue.8 , pp. 1137-1143
    • Falleti, E.1    Fabris, C.2    Cmet, S.3
  • 148
    • 84901608440 scopus 로고    scopus 로고
    • Association between the PNPLA3 (rs738409 C>G) variant and hepatocellular carcinoma: Evidence from a meta-analysis of individual participant data
    • Trépo E., Nahon P., Bontempi G., et al. Association between the PNPLA3 (rs738409 C>G) variant and hepatocellular carcinoma: evidence from a meta-analysis of individual participant data. Hepatology: 2014; 59 6 2170 2177
    • (2014) Hepatology , vol.59 , Issue.6 , pp. 2170-2177
    • Trépo, E.1    Nahon, P.2    Bontempi, G.3
  • 149
    • 84859147155 scopus 로고    scopus 로고
    • PNPLA3 (rs738409 C>G) is a common risk variant associated with hepatocellular carcinoma in alcoholic cirrhosis
    • Trepo E., Guyot E., Ganne-Carrie N., et al. PNPLA3 (rs738409 C>G) is a common risk variant associated with hepatocellular carcinoma in alcoholic cirrhosis. Hepatology: 2012; 55 4 1307 1308
    • (2012) Hepatology , vol.55 , Issue.4 , pp. 1307-1308
    • Trepo, E.1    Guyot, E.2    Ganne-Carrie, N.3
  • 150
    • 84932130955 scopus 로고    scopus 로고
    • A common polymorphism in the NCAN gene is associated with hepatocellular carcinoma in alcoholic liver disease
    • Nischalke H. D., Lutz P., Krämer B., et al. A common polymorphism in the NCAN gene is associated with hepatocellular carcinoma in alcoholic liver disease. J Hepatol: 2014; 61 5 1073 1079
    • (2014) J Hepatol , vol.61 , Issue.5 , pp. 1073-1079
    • Nischalke, H.D.1    Lutz, P.2    Krämer, B.3
  • 151
    • 84926422287 scopus 로고    scopus 로고
    • Reply to: HCC and liver disease risk in homozygous PNPLA3 p.I148M carriers approach monogenic inheritance
    • Anstee Q. M., Liu Y. L., Day C. P., Reeves H. L. Reply to: HCC and liver disease risk in homozygous PNPLA3 p.I148M carriers approach monogenic inheritance. J Hepatol: 2015; 62 4 982 983
    • (2015) J Hepatol , vol.62 , Issue.4 , pp. 982-983
    • Anstee, Q.M.1    Liu, Y.L.2    Day, C.P.3    Reeves, H.L.4
  • 152
    • 84880920122 scopus 로고    scopus 로고
    • Bringing genome-wide association findings into clinical use
    • Manolio T. A. Bringing genome-wide association findings into clinical use. Nat Rev Genet: 2013; 14 8 549 558
    • (2013) Nat Rev Genet , vol.14 , Issue.8 , pp. 549-558
    • Manolio, T.A.1
  • 153
    • 84867573089 scopus 로고    scopus 로고
    • S-adenosylmethionine (SAMe) therapy in liver disease: A review of current evidence and clinical utility
    • Anstee Q. M., Day C. P. S-adenosylmethionine (SAMe) therapy in liver disease: a review of current evidence and clinical utility. J Hepatol: 2012; 57 5 1097 1109
    • (2012) J Hepatol , vol.57 , Issue.5 , pp. 1097-1109
    • Anstee, Q.M.1    Day, C.P.2
  • 154
    • 50349090249 scopus 로고    scopus 로고
    • Alcohol-intoxicating roadblocks and bottlenecks in hepatic protein and lipid metabolism
    • Molina P. E. Alcohol-intoxicating roadblocks and bottlenecks in hepatic protein and lipid metabolism. Am J Physiol Endocrinol Metab: 2008; 295 1 E1 E2
    • (2008) Am J Physiol Endocrinol Metab , vol.295 , Issue.1 , pp. E1-E2
    • Molina, P.E.1
  • 156
    • 77950625747 scopus 로고    scopus 로고
    • Patatin-like phospholipase domain containing 3: A case in point linking genetic susceptibility for alcoholic and nonalcoholic liver disease
    • Seth D., Daly A. K., Haber P. S., Day C. P. Patatin-like phospholipase domain containing 3: a case in point linking genetic susceptibility for alcoholic and nonalcoholic liver disease. Hepatology: 2010; 51 4 1463 1465
    • (2010) Hepatology , vol.51 , Issue.4 , pp. 1463-1465
    • Seth, D.1    Daly, A.K.2    Haber, P.S.3    Day, C.P.4
  • 157
    • 78751536418 scopus 로고    scopus 로고
    • Genetic variation in the PNPLA3 gene is associated with alcoholic liver injury in Caucasians
    • Stickel F., Buch S., Lau K., et al. Genetic variation in the PNPLA3 gene is associated with alcoholic liver injury in Caucasians. Hepatology: 2011; 53 1 86 95
    • (2011) Hepatology , vol.53 , Issue.1 , pp. 86-95
    • Stickel, F.1    Buch, S.2    Lau, K.3
  • 158
    • 79959561798 scopus 로고    scopus 로고
    • Common polymorphism in the PNPLA3/adiponutrin gene confers higher risk of cirrhosis and liver damage in alcoholic liver disease
    • Trépo E., Gustot T., Degré D., et al. Common polymorphism in the PNPLA3/adiponutrin gene confers higher risk of cirrhosis and liver damage in alcoholic liver disease. J Hepatol: 2011; 55 4 906 912
    • (2011) J Hepatol , vol.55 , Issue.4 , pp. 906-912
    • Trépo, E.1    Gustot, T.2    Degré, D.3
  • 159
    • 84906260329 scopus 로고    scopus 로고
    • Is pnpla3 polymorphism involved in severe acute alcoholic hepatitis
    • Nguyen-Khac E., Houchi H., Dreher M. L., et al. Is pnpla3 polymorphism involved in severe acute alcoholic hepatitis. Hepatology: 2011; 54 976a
    • (2011) Hepatology , vol.54 , pp. 976a
    • Nguyen-Khac, E.1    Houchi, H.2    Dreher, M.L.3
  • 160
    • 84856026934 scopus 로고    scopus 로고
    • A common variant of PNPLA3 (p.I148M) is not associated with alcoholic chronic pancreatitis
    • Rosendahl J., Tönjes A., Schleinitz D., et al. A common variant of PNPLA3 (p.I148M) is not associated with alcoholic chronic pancreatitis. PLoS ONE: 2012; 7 1 e29433
    • (2012) PLoS ONE , vol.7 , Issue.1 , pp. e29433
    • Rosendahl, J.1    Tönjes, A.2    Schleinitz, D.3
  • 161
    • 84890092349 scopus 로고    scopus 로고
    • Genetic factors affecting susceptibility to alcoholic liver disease in an Indian population
    • Dutta A. K. Genetic factors affecting susceptibility to alcoholic liver disease in an Indian population. Ann Hepatol: 2013; 12 6 901 907
    • (2013) Ann Hepatol , vol.12 , Issue.6 , pp. 901-907
    • Dutta, A.K.1
  • 162
    • 84895819606 scopus 로고    scopus 로고
    • PNPLA3 I148M (rs738409) genetic variant and age at onset of at-risk alcohol consumption are independent risk factors for alcoholic cirrhosis
    • Burza M. A., Molinaro A., Attilia M. L., et al. PNPLA3 I148M (rs738409) genetic variant and age at onset of at-risk alcohol consumption are independent risk factors for alcoholic cirrhosis. Liver Int: 2014; 34 4 514 520
    • (2014) Liver Int , vol.34 , Issue.4 , pp. 514-520
    • Burza, M.A.1    Molinaro, A.2    Attilia, M.L.3
  • 163
    • 84895823188 scopus 로고    scopus 로고
    • The Pnpa3 I148m mutation significantly increases the risk of developing alcohol-related cirrhosis in alcohol dependent individuals
    • Way M. J., McQuillin A., Gurling H. MD., et al. The Pnpa3 I148m mutation significantly increases the risk of developing alcohol-related cirrhosis in alcohol dependent individuals. J Hepatol: 2013; 58 S563 S564
    • (2013) J Hepatol , vol.58 , pp. S563-S564
    • Way, M.J.1    McQuillin, A.2    Gurling, H.M.3


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