Alcohol dehydrogenase-2*3 allele protects against alcohol-related birth defects among African Americans

Journal of Pharmacology and Experimental Therapeutics

Volumn 283, Issue 3, 1997, Pages 1095-1101

  Mccarver, D G ^b,d   Thomasson, H R ^a,c   Martier, S S ^b   Sokol, R J ^b   Li, T K ^c  

^a WISHARD MEMORIAL HOSPITAL   (United States)

^b WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c INDIANA UNIVERSITY   (United States)

^d CHILDREN'S HOSPITAL OF MICHIGAN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL DEHYDROGENASE;

ALCOHOL CONSUMPTION; ALCOHOL INTOXICATION; ALCOHOL METABOLISM; ALLELE; ARTICLE; BIRTH DEFECT; GENE LOCUS; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MENTAL DEFICIENCY; NEGRO; PRIORITY JOURNAL;

ABNORMALITIES, DRUG-INDUCED; ADOLESCENT; ADULT; AFRICAN CONTINENTAL ANCESTRY GROUP; ALCOHOL DEHYDROGENASE; ALLELES; FEMALE; GENOTYPE; GROWTH; HUMANS; INFANT, NEWBORN; ISOENZYMES; MALE; PREGNANCY;

EID: 0031456078     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (67)

1. ABEL, E. L. AND DINTCHEFF, B. A.: Factors affecting the outcome of maternal alcohol exposure: II. Maternal age. Neurobehav. Toxicol. Teratol. 7: 263-266, 1985.
2. ANG, H. L., DELTOUR, L., ZGOMBIC-KNIGHT, M., WAGNER, M. A. AND DUESTER, G.: Expression patterns of class I and class IV alcohol dehydrogenase genes in developing epithelia suggest a role for alcohol dehydrogenase in local retinoic acid synthesis. Alcohol. Clin. Exp. Res. 20: 1050-1064, 1996.
3. BOLEDA, M. D., SAUBI, N., FARRÉS, J. AND PARES, X.: Physiological substrates for rat alcohol dehydrogenase Classes: aldehydes of lipid peroxidation, cuhydroxyfatty acids, and retinoids. Arch. Biochem. Biophys. 307: 85-90, 1993.
4. BONTHIUS, D. J., GOODLETT, C. R. AND WEST, J. R.: Blood alcohol concentration and severity of microencephaly in neonatal rats depend on the pattern of alcohol administration. Alcohol 5: 209-214, 1988.
5. BOSRON, W. F. AND Li, T. K.: Catalytic properties of human liver alcohol dehydrogenase isoenzymes. Enzyme 37: 19-28, 1987.
6. BOSRON, W. F., MAGNES, L. J. AND LI, T. K.: Kinetic and electrophoretic properties of native and recombined isoenzymes of human liver alcohol dehydrogenase. Biochemistry 22: 1852-1857, 1983a.
7. 2 gene locus. Biochem. Genet. 21: 735-744, 1983b.
8. BOSRON, W. F., REX, D. K., HARDEN, C. A., LI, T.-K. AND AKERSON, R. D.: Alcohol and aldehyde dehydrogenase isoenzymes in Sioux North American Indians. Alcohol. Clin. Exp. Res. 12: 454-455, 1988.
9. BOWMAN, R. S., STEIN, L. I. AND NEWTON, J. R.: Measurement and interpretation of drinking behavior. J. Stud. Alcohol. 36: 1154-1172, 1975.
10. BURNELL, J. C., LI, T. K. AND BOSRON, W. F.: Purification and steady-state kinetic characterization of human liver β3β3 alcohol dehydrogenase. Biochemistry 28: 6810-6815, 1989.
11. CENTERS FOR DISEASE CONTROL: Fetal alcohol syndrome - United States, 1979-1992. MMWR 42: 339-341, 1993.
12. 2 in Northwest Coast Amerindians. Hum. Genet. 89: 351-352, 1992.
13. CHERNOFF, G. F.: The fetal alcohol syndrome in mice: Maternal variables. Teratology 22: 71-75, 1980.
14. CHRISTOFFEL, K. K. AND SALAFSKY, I.: Fetal alcohol syndrome in dizygotic twins. J. Pediatr. 87: 963-967, 1975.
15. CHURCH, M. W., ABEL, E. L., DINTCHEFF, B. A. AND MATYJASIK, C.: Maternal age and blood alcohol concentration in the pregnant Long-Evans rat. J. Pharmacol. Exp. Ther. 253: 192-199, 1990.
16. COUZIGOU, P., FLEURY, B., GROPPI, A., CASSAIGNE, A., BEGUERET, J., IRON, A. AND THE FRENCH GROUP FOR RESEARCH ON ALCOHOL AND LIVER: Genotyping study of alcohol dehydrogenase class I polymorphism in French patients with alcoholic cirrhosis. Alcohol Alcohol. 25: 623-626, 1990.
17. GRAIN, L. S., FITZMAURICE, N. E. AND MONDRY, C.: Nail dysplasia and fetal alcohol syndrome: Case report of a heteropaternal sibship. Am. J. Dis. Child. 137: 1069-1072, 1983.
18. DILTS, P. V.: Placental transfer of ethanol. Am. J. Obstet. Gynecol. 107: 1195-1198, 1970.
19. DUESTER, G.: A hypothetical mechanism for fetal alcohol syndrome involving ethanol inhibition of retinoic acid synthesis at the alcohol dehydrogenase step. Alcohol. Clin. Exp. Res. 15: 568-572, 1991.
20. DUESTER, G., SHEAN, M. L., MCBRIDE, M. S. AND STEWART, M. J.: Retinoic acid response element in the human alcohol dehydrogenase gene ADH3: Implications for regulation of retinoic acid synthesis. Mol. Cell. Biol. 11: 1638-1646, 1991.
21. EHRIG, T., BOSRON, W. F. AND LI, T. K.: Alcohol and aldehyde dehydrogenase. Alcohol Alcohol. 25: 105-116, 1990.
22. FAUSTMAN, E. M., STREISSGUTH, A. P., STEVENSON, L. M., OMENN, G. S. AND YOSHIDA, A.: Role of maternal and fetal alcohol metabolizing genotypes in fetal alcohol syndrome. Toxicologist 12: 1562, 1992.
23. GOLDEN, N. L., SOKOL, R. J., KUHNERT, B. R. AND BOTTOMS, S.: Maternal alcohol use and infant development. Pediatrics 70: 931-934, 1982.
24. GOODLETT, C. R., GILLIAM, D. M., NICHOLS, J. M. AND WEST, J. R.: Genetic influences on brain growth restriction induced by developmental exposure to alcohol. Neurotoxicology 10: 321-334, 1989.
25. GOODLETT, C. R., MARCUSSEN, B. L. AND WEST, J. R.: A single day of alcohol exposure during the brain growth spurt induces brain weight restriction and cerebellar Purkinje cell loss. Alcohol 7: 107-114, 1990.
26. GRUMMER, M. A., LANGHOUGH, R. E. AND ZACHMAN, R. D.: Maternal ethanol ingestion effects on fetal rat brain vitamin A as a model for fetal alcohol syndrome. Alcohol. Clin. Exp. Res. 17: 592-597, 1993.
27. GRUMMER, M. A. AND ZACHMAN, R. D.: The effect of maternal ethanol ingestion on fetal vitamin A in the rat. Pediatr. Res. 28: 186-189, 1990.
28. HELANDER, A., WALZER, C., BECK, O., BALANT, L., BORG, S. AND VON WARTBURG, J. P.: Influence of genetic variation in alcohol and aldehyde dehydrogenase on serotonin metabolism. Life. Sci. 55: 359-366, 1994.
29. HOLFORD, N. H. G.: Clinical pharmacokinetics of ethanol. Clin. Pharmacokinet. 13: 273-292, 1987.
30. JORNVALL, H. AND HOOG, J. O.: Nomenclature of alcohol dehydrogenases. Alcohol Alcohol. 30: 153-161, 1995.
31. KASSAM, J. P., TANG, B. K., KADAR, D. AND KALOW, W.: In vitro studies of human liver alcohol dehydrogenase variants using a variety of substrates. Drug. Metab. Dispol. Biol. Fate. Chem. 17: 567-572, 1989.
32. MAEZAWA, Y., YAMAUCHI, M., TODA, G., SUZUKI, H. AND SAKURAI, S.: Alcohol-metabolizing enzyme polymorphisms and alcoholism in Japan. Alcohol. Clin. Exp. Res. 19: 951-954, 1995.
33. MARDH, G., LUEHR, C. A. AND VALLEE, B. L.: Human class I alcohol dehydrogenases catalyze the oxidation of glycols in the metabolism of norepinephrine. Proc. Natl. Acad. Sci. U.S.A. 82: 4979-4982, 1985.
34. MARDH, G. AND VALLEE, B. L.: Human class I alcohol dehydrogenases catalyze the interconversion of alcohols and aldehydes in the metabolism of dopamine. Biochemistry 25: 7279-7282, 1986.
35. MARTIN, N. G., PERL, J., OAKERSHOTT, J. G., GIBSON, J. B., STARMER, G. A. AND WILKS, A. V.: A twin study of ethanol metabolism. Behav. Genet. 15: 93-105, 1985.
36. MEZEY, E.: Ethanol metabolism and ethanol-drug interactions. Biochem. Pharmacol. 25: 869-875, 1976.
37. MITCHELL, D. Y. AND PETERSEN, D. R.: The oxidation of alpha-beta unsaturated aldehydic products of lipid peroxidation by rat liver aldehyde dehydrogenases. Toxicol. Appl. Pharmacol. 87: 403-410, 1987.
38. MURAMATSU, T., WANG, Z. C., FANG, Y. R., HU, K. B., YAN, H., YAMADA, K., HIGUCHI, S., HARADA, S. AND KONO, H.: Alcohol and aldehyde dehydrogenase genotypes and drinking behavior of Chinese living in Shanghai. Hum. Genet. 96: 151-154, 1995.
39. PARES, X., FARRES, J., PARES, A., SOLER, X., PANES, J., FERRE, J. L., CABALLERIA, J. AND RODES, J.: Genetic polymorphism of liver alcohol dehydrogenase in Spanish subjects: Significance of alcohol consumption and liver disease. Alcohol Alcohol. 29: 701-705, 1994.
40. PIKKARAINEN, P. H. AND RAIHA, N. C. R.: Development of alcohol dehydrogenase activity in the human liver. Pediatr. Res. 1: 165-168, 1967.
41. POUPON, R. E., NALPAS, B., COUTELLE, C., FLEURY, B., COUZIGOU, P., HIGUERET, D. AND THE FRENCH GROUP FOR RESEARCH ON ALCOHOL AND LIVER: Polymorphism of alcohol dehydrogenase, alcohol and aldehyde dehydrogenase activities: implication in alcoholic cirrhosis in white patients. Hepatology 15: 1017-1022, 1992.
42. PULLARKAT, R. K.: Hypothesis: Prenatal ethanol-induced birth defects and retinoic acid. Alcohol. Clin. Exp. Res. 15: 565-567, 1991.
43. REX, D. K., BOSRON, W. F., SMIALEK, J. E. AND LI, T.-K.: Alcohol and aldehyde dehydrogenase isoenzymes in North American Indians. Alcohol. Clin. Exp. Res. 9: 147-152, 1985.
44. RIESE, M. L.: Maternal alcohol and pentazocine abuse: neonatal behavior and morphology in an opposite-sex twin pair. Acta Genet. Med. Gemellol. 38: 49-56, 1989.
45. SELLIN, S., HOLMQUIST, B., MANNERVIK, B. AND VALLEE, B. L.: Oxidation and reduction of 4-hydroxyalkenals catalyzed by isozymes of human alcohol dehydrogenase. Biochemistry 30: 2514-2518, 1991.
46. SHIBUYA, A. AND YOSHIDA, A.: Genotypes of alcohol-metabolizing enzymes in Japanese with alcohol liver diseases: A strong association of the usual Caucasian-type aldehyde dehydrogenase gene (ALDH1(2)) with the disease. Am. J. Hum. Genet. 43: 744-748, 1988.
47. SMITH, M., HOPKINSON, D. A. AND HARRIS, H.: Developmental changes and polymorphism in human alcohol dehydrogenase. Ann. Hum. Genet. 34: 251-271, 1971.
48. 3. Ann. Hum. Genet. 37: 49-67, 1973.
49. SOKOL, R., AGER, J., MARTIER, S., DEBANNE, S., ERNHART, C., KUZMA, J. AND MILLER, S. I.: Significant determinants of susceptibility to alcohol teratogenicity. Ann. N.Y. Acad. Sci. 477: 87-102, 1986.
50. SOKOL, R. J., MILLER, S. I. AND REED, G.: Alcohol abuse during pregnancy: An epidemiologic study. Alcohol. Clin. Exp. Res. 4: 135-145, 1980.
51. STEWART, M. J., SHEAN, M. L., PAEPER, B. W. AND DUESTER, G.: The role of CCAAT/enhancer-binding protein in the differential transcriptional regulation of a family of human liver alcohol dehydrogenase genes. J. Biol. Chem. 266: 11594-11603, 1991.
52. STREISSGUTH, A. P., BARR, H. M., MARTIN, D. C. AND HERMAN, C. S.: Effects of maternal alcohol, nicotine, and caffeine use during pregnancy on infant mental and motor development at eight months. Alcohol. Clin. Exp. Res. 4: 152-164, 1980.
53. STREISSGUTH, A. P. AND DEHAENE, P.: Fetal alcohol syndrome in twins of alcoholic mothers: Concordance of diagnosis and IQ. Am. J. Med. Genet. 47: 857-861, 1993.
54. TANAKA, F., SHIRATORI, Y., YOKOSUKA, O., IMAZEKI, F., TSUKADA, Y. AND OMATA, M.: High incidence of ADH2*1/ALDH2*1 genes among Japanese alcohol dependents and patients with alcoholic liver disease. Hepatology 23: 234-239, 1996.
55. THOMASSON, H. R., EDENBERG, H. J., CRABB, D. W., MAI, X. L., JEROME, R. E., LI, T. K., WANG, S. P., LIN, Y. T., LU, R. B. AND YIN, S. J.: Alcohol and aldehyde dehydrogenase genotypes and alcoholism in Chinese men. Am. J. Hum. Genet. 48: 677-681, 1991.
56. THOMASSON, H. R., BEARD, J. D. AND LI, T.-K.: ADH2 gene polymorphisms are determinants of alcohol pharmacokinetics. Alcohol. Clin. Exp. Res. 19: 1494-1499, 1995.
57. VAN OOIJ, C., SNYDER, R. C., PAEPER, B. W. AND DUESTER, G.: Temporal expression of the human alcohol dehydrogenase gene family during liver development correlates with differential promoter activation by hepatocyte nuclear factor I, CCAAT/enhancer-binding protein, liver activator protein, and D-element-binding protein. Mol. Cell. Biol. 12: 3023-3031, 1992.
58. VESELL, E. S., PAGE, J. G. AND PASSANANTI, G. T.: Genetic and environmental factors affecting ethanol metabolism in man. Clin. Pharmacol. Ther. 12: 192-201, 1971.
59. VIDAL, F., PEREZ, J., PANISELLO, J., TODA, R., GUTIERREZ, C. AND RICHART, C.: Atypical liver alcohol dehydrogenase in the Spanish population: Its relation with the development of alcoholic liver disease. Alcohol. Clin. Exp. Res. 17: 782-785, 1993.
60. m for elimination of alcohol in young male subjects following low doses of alcohol. Alcohol Alcohol. 24: 555-564, 1989.
61. WEST, J. R., GOODLETT, C. R., BONTHIUS, D. J., HAMRE, K. M. AND MARCUSSEN, B. L.: Cell population depletion associated with fetal alcohol brain damage: Mechanisms of BAC-dependent cell loss. Alcohol. Clin. Exp. Res. 14: 813-818, 1990.
62. WHITFIELD, J. B. AND MARTIN, N. G.: Alcohol reactions in subjects of European descent: Effects on alcohol use and on physical and psychomotor responses to alcohol. Alcohol. Clin. Exp. Res. 20: 81-86, 1996.
63. XU, Y., CARR, L. G., BOSRON, W. F., LI, T. K. AND EDENBERG, H. J.: Genotyping of human alcohol dehydrogenases at the ADH2 and ADH3 loci following DNA sequence amplification. Genomics 2: 209-214, 1988.
64. YAMAUCHI, M., MAEZAWA, Y., MIZUHARA, Y., OHATA, M., HIRAKAWA, J., NAKAJIMA, H. AND TODA, G.: Polymorphisms in alcohol metabolizing enzyme genes and alcoholic cirrhosis in Japanese patients: A multivariate analysis. Hepatology 22: 1136-1142, 1995a.
65. YAMAUCHI, M., MAEZAWA, Y., TODA, G., SUZUKI, H. AND SAKURAI, S.: Association of a restriction fragment length polymorphism in the alcohol dehydrogenase 2 gene with Japanese alcoholic liver cirrhosis. J. Hepatol. 23: 519-523, 1995b.
66. YANG, Z. N., DAVIS, G. J., HURLEY, T. D., STONE, C. L., LI, T. K. AND BOSRON, W. F.: Catalytic efficiency of human alcohol dehydrogenases for retinol oxidation and retinal reduction. Alcohol. Clin. Exp. Res. 18: 587-591, 1994.
67. ZGOMBIC-KNIGHT, M., SATRE, M. A. AND DUESTER, G.: Differential activity of the promoter for the human alcohol dehydrogenase (retinol dehydrogenase) gene ADH3 in neural tube of transgenic mouse embryos. J. Biol. Chem. 269: 6790-6795, 1994.