Heterozygotes for HFE mutations have no increased risk of advanced alcoholic liver disease

Gut

Volumn 43, Issue 2, 1998, Pages 262-266

  Grove, J ^a,b   Daly, A K ^b   Burt, A D ^a   Guzail, M ^a   James, O F W ^a   Bassendine, M F ^a   Day, C P ^a,c  

^a NEWCASTLE UNIVERSITY   (United Kingdom)

^b Dept of Pharmacological Sciences ^*

^c NEWCASTLE UNIVERSITY   (United Kingdom)

Author keywords

Alcohol; Haemochromatosis; Haemosiderosis; Iron overload; Liver disease; Polymorphism

Indexed keywords

IRON;

ALCOHOL LIVER DISEASE; ARTICLE; CONTROLLED STUDY; FEMALE; GENE MUTATION; GENETIC POLYMORPHISM; GENETIC RISK; HEMOCHROMATOSIS; HEMOSIDEROSIS; HETEROZYGOTE; HUMAN; HUMAN TISSUE; IRON OVERLOAD; IRON STORAGE; LIVER BIOPSY; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; RISK ASSESSMENT;

EID: 0031820034     PISSN: 00175749     EISSN: None     Source Type: Journal    
DOI: 10.1136/gut.43.2.262     Document Type: Article

References (28)

1. Dadone MM, Kushner JP, Edwards CQ, et al. Hereditary hemochromatosis: analysis of laboratory expression of the disease by genotype in 18 pedigrees. Am J Clin Pathol 1982;78:196-207.
2. Feder JN, Gnirke A, Thomas W, et al. A novel MHC class I-like gene is mutated in patients with hereditary hemochromatosis. Nat Genet 1996;13:399-408.
3. Calandro L, Thorsen T, Barcellos L, et al. Mutation analysis in hereditary hemochromatosis. Blood Cells Mol Dis 1996;22:194A-94B.
4. Jazwinska EC, Cullen LM, Busfield F, et al. Haemochromatosis and HLA-H. Nat Genet 1996;14:249-51.
5. Jouanolle AM, Gandon G, Jezequel P, et al. Haemochromatosis and HLA-H. Nat Genet 1996;14:251-2.
6. The UK Haemochromatosis Consortium. A simple genetic test identifies 90% of UK patients with haemochromatosis. Gut 1997;41:841-4.
7. Beutler E. Genetic irony beyond hemochromatosis: clinical effects of HLA-H mutations. Lancet 1997;349:296-7.
8. Roberts AG, Whatley SD, Morgan RR, et al. Increased frequency of the hemochromatosis Cys282Tyr mutation in sporadic porphyria cutanea tarda. Lancet 1997;349:321-3.
9. Tsukamoto H, Home W, Kamimura S, et al. Experimental liver cirrhosis induced by alcohol and iron. J Clin Invest 1995;96:620-30.
10. Stal P, Hultcranz R. Iron increases ethanol toxicity in rat liver. J Hepatol 1993;17:108-15.
11. Adams PC, Agnew S. Alcoholism in hereditary hemochromatosis revisited: prevalence and clinical consequences among homozygous siblings. Hepatology 1996;23:724-7.
12. Le Sage GD, Baldus WB, Fairbanks VF, et al. Hemochromatosis: genetic or alcohol-induced? Gastroenterology 1983;84:1471-7.
13. Day CP. Is necroinflammation a prerequisite for fibrogenesis? Hepato-Gastroenterology 1996;43:104-20.
14. Day CP, Bassendine MF. Genetic predisposition to alcoholic liver disease. Gut 1992;33:1444-7.
15. Lelbach WK. Cirrhosis in the alcoholic and its relation to the volume of alcohol abuse. Ann NY Acad Sci 1975;252: 85-105.
16. Hrubec Z, Omenn GS. Evidence of a genetic predisposition to alcoholic cirrhosis and psychosis; twin concordances for alcoholism and its biological end points by zygosity among male veterans. Alcohol Clin Exp Res 1981;9:306-9.
17. Grove J, Daly AK, Brown AstJM, et al. The RsaI polymorphism of CYP2E1 and susceptibility to alcoholic liver disease in Caucasians: effect on age of presentation and dependence on alcohol dehydrogenase genotype. Pharmacogenetics (in press).
18. Grove J, Daly AK, Bassendine MF, et al. Association of a tumor necrosis factor polymorphism with susceptibility to alcoholic steatohepatitis. Hepatology 1997;26:143-6.
19. Ludwig J, Hashimoto H, Porayko MK, et al. Hemosiderosis in cirrhosis: a study of 447 native livers. Gastroenterology 1997;112:882-8.
20. Searle J, Kerr JFR, Halliday JW, et al. Iron storage disease. In: MacSween RNM, Anthony PP, Scheuer PJ et al, eds. Pathology of the liver. 3rd edn. New York: Churchill Livingstone, 1994:219-41.
21. Bulaj ZL, Griffen LM, Jorde LB, et al. Clinical and biochemical abnormalities in people heterozygous for hemochromatosis. N Eng J Med 1996;335:1799-805.
22. Teare J, Mantafounis D, Yallop R, et al. Increased frequency of the haemochromatosis allele in patients with alcoholic liver disease. J Hepatol 1997;26(suppl 1):57.
23. Simon M, Bourel M, Genetet B, et al. Idiopathic hemochromatosis and iron overload in alcoholic liver disease: differentiation by HLA phenotype. Gastroenterology 1977;73:655-8.
24. Chapman RW, Murgan MY, Laulicht M, et al. Hepatic iron stores and markers of iron overload in alcoholics and patients with idiopathic hemochromatosis. Dig Dis Sci 1982;27:909-16.
25. Bassett ML, Halliday JW, Powell LW. Value of hepatic iron measurements in early hemochromatosis and determination of the critical iron level associated with fibrosis. Hepatology 1986;6:24-9.
26. MacDonald RA, Jones RS, Pechet GS. Folic acid deficiency and hemochromatosis. Arch Pathol 1965;80:153-60.
27. Rouault TA, Klausner RD. Iron-sulfur clusters as biosensors of oxidants and iron. Trends Biochem Sci 1996;21:174-7.
28. Ganne-Carrie N, Christidis C, Chevret S, et al. Predictive value of liver iron content tor survival in 229 prospectively followed patients with cirrhosis. J Hepatol 1996;25(suppl 1):95.