Confirmation of association of the GABRA2 gene with alcohol dependence by subtype-specific analysis

Psychiatric Genetics

Volumn 16, Issue 1, 2006, Pages 9-17

  Fehr, Christoph ^a   Sander, Thomas ^b   Tadic, Andre ^c   Lenzen, Kirsten P ^b   Anghelescu, Ion ^c   Klawe, Christoph ^d   Dahmen, Norbert ^a   Schmidt, Lutz G ^a   Szegedi, Armin ^e  

^a JOHANNES GUTENBERG UNIVERSITY   (Germany)

^b MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

^c CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^d KRANKENHAUS DER BARMHERZIGEN BRÜDER   (Germany)

^e Global Clinical Development   (United States)

Author keywords

aminobutyric acid; Alcoholism; Delirium; Early onset; Genetics; Withdrawal

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; GABRA2 PROTEIN, HUMAN;

ALCOHOLISM; ALLELE; ARTICLE; CONFIDENCE INTERVAL; CONTROLLED STUDY; FAMILY HISTORY; GENE MAPPING; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENETIC LOAD; GENETIC PREDISPOSITION; GENETIC RISK; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; GENOTYPE; GERMANY; HAPLOTYPE; HUMAN; MAJOR CLINICAL STUDY; ONSET AGE; POPULATION GENETICS; PREVALENCE; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; STATISTICAL SIGNIFICANCE; WITHDRAWAL SEIZURE; ADULT; CASE CONTROL STUDY; FEMALE; GENE DOSAGE; GENE LINKAGE DISEQUILIBRIUM; GENETICS; MALE; POLYMERASE CHAIN REACTION;

ADULT; ALCOHOLISM; ALLELES; CASE-CONTROL STUDIES; FEMALE; GENE DOSAGE; GENOTYPE; HAPLOTYPES; HUMANS; LINKAGE DISEQUILIBRIUM; MALE; POLYMERASE CHAIN REACTION; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTORS, GABA-A;

EID: 33646708528     PISSN: 09558829     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.ypg.0000185027.89816.d9     Document Type: Article

References (44)

1. Ardlie KG, Kruglyak L, Seielstad M (2002). Patterns of linkage disequilibrium in the human genome. Nat Rev Genet 3:299-309.
2. Association AP (1994). Diagnostic and statistical manual of mental disorders, fourth edition (DSM IV). 4th ed. Washington, District of Columbia: American Psychiatric Association.
3. Babor TF, Hofmann M, DelBoca FK, Hesselbrock V, Meyer RE, Dolinsky ZS, Rounsaville B (1992). Types of alcoholics, I. Evidence for an empirically derived typology based on indicators of vulnerability and severity. Arch Gen Psychiatry 49:599-608.
4. Benke D, Fakitsas P, Roggenmoser C, Michel C, Rudolph U, Mohler H (2004). Analysis of the presence and abundance of GABAA receptors containing two different types of alpha subunits in murine brain using point-mutated alpha subunits. J Biol Chem 279:43654-43660.
5. Boehm SL 2nd, Ponomarev I, Jennings AW, Whiting PJ, Rosahl TW, Garrett EM, et al. (2004). Gamma-aminobutyric acid A receptor subunit mutant mice: new perspectives on alcohol actions. Biochem Pharmacol 68:1581-1602.
6. Cardon LR, Palmer LJ (2003). Population stratification and spurious allelic association. Lancet 361:598-604.
7. Chang Y, Wang R, Barot S, Weiss DS (1996). Stoichiometry of a recombinant GABAA receptor. J Neurosci 16:5415-5424.
8. Cloninger CR, Bohman M, Sigvardsson S (1981). Inheritance of alcohol abuse. Cross-fostering analysis of adopted men. Arch Gen Psychiatry 38:861-868.
9. Covault J, Gelernter J, Hesselbrock V, Nellissery M, Kranzler HR (2004). Allelic and haplotypic association of GABRA2 with alcohol dependence. Am J Med Genet 129B:104-109.
10. Davies M (2003). The role of GABAA receptors in mediating the effects of alcohol in the central nervous system. J Psychiatry Neurosci 28:263-274.
11. Dudbridge F (2003). Pedigree disequilibrium tests for multilocus haplotypes. Genet Epidemiol 25:115-121.
12. Edenberg HJ, Dick DM, Xuei X, Tian H, Almasy L, Bauer LO, et al. (2004). Variations in GABRA2, encoding the alpha 2 subunit of the GABA(A) receptor, are associated with alcohol dependence and with brain oscillations. Am J Hum Genet 74:705-714.
13. Fallin D, Schork NJ (2000). Accuracy of haplotype frequency estimation for biallelic loci, via the expectation-maximization algorithm for unphased diploid genotype data. Am J Hum Genet 67:947-959.
14. Follesa P, Biggio F, Mancuso L, Cabras S, Caria S, Gorini G, et al. (2004). Ethanol withdrawal-induced up-regulation of the alpha2 subunit of the GABAA receptor and its prevention by diazepam or gamma-hydroxybutyric acid. Brain Res Mol Brain Res 120:130-137.
15. Fritschy JM, Weinmann O, Wenzel A, Benke D (1998). Synapse-specific localization of NMDA and GABA(A) receptor subunits revealed by antigen-retrieval immunohistochemistry. J Comp Neurol 390:194-210.
16. Grant BF, Dawson DA, Stinson FS, Chou SP, Dufour MC, Pickering RP (2004). The 12-month prevalence and trends in DSM-IV alcohol abuse and dependence: United States, 1991-1992 and 2001-2002. Drug Alcohol Depend 4:223-234.
17. Heath AC, Bucholz KK, Madden PA, Dinwiddie SH, Slutske WS, Bierut LJ, et al. (1997). Genetic and environmental contributions to alcohol dependence risk in a national twin sample: consistency of findings in women and men. Psychol Med 27:1381-1396.
18. Horikawa Y, Oda N, Cox NJ, Li X, Orho-Melander M, Hara M, et al. (2000). Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus. Nat Genet 26:163-175.
19. Johnson EO, van den Bree MB, Pickens RW (1996). Subtypes of alcohol-dependent men: a typology based on relative genetic and environmental loading. Alcohol Clin Exp Res 20:1472-1480.
20. Kendler KS (2001). Twin studies of psychiatric illness: an update. Arch Gen Psychiatry 58:1005-1014.
21. Korpi ER, Grunder G, Luddens H (2002). Drug interactions at GABA(A) receptors. Prog Neurobiol 67:113-159.
22. Lappalainen J, Krupitsky E, Remizov M, Pchelina S, Taraskina A, Zvartau E, et al. (2005). Association between alcoholism and gamma-amino butyric acid alpha2 receptor subtype in a Russian population. Alcohol Clin Exp Res 29:493-498.
23. Livak KJ (1999). Allelic discrimination using fluorogenic probes and the 5′ nuclease assay. Genet Anal 14:143-149.
24. Long JC, Knowler WC, Hanson RL, Robin RW, Urbanek M, Moore E, et al. (1998). Evidence for genetic linkage to alcohol dependence on chromosomes 4 and 11 from an autosome-wide scan in an American Indian population. Am J Med Genet 81:216-221.
25. Low K, Crestani F, Keist R, Benke D, Brunig I, Benson JA, et al. (2000). Molecular and neuronal substrate for the selective attenuation of anxiety. Science 290:131-134.
26. Mann K (2004). Pharmacotherapy of alcohol dependence: a review of the clinical data. CNS Drugs 18:485-504.
27. Mohler H, Fritschy JM, Rudolph U (2002). A new benzodiazepine pharmacology. J Pharmacol Exp Ther 300:2-8.
28. Parsian A, Zhang ZH (1999). Human chromosomes 11p15 and 4p12 and alcohol dependence: possible association with the GABRB1 gene. Am J Med Genet 88:533-538.
29. Perkonigg A, Lieb R, Wittchen HU (1998). Substance use, abuse and dependence in Germany. A review of selected epidemiological data. Eur Addict Res 4:8-17.
30. Pierucci-Lagha A, Covault J, Feinn R, Nellissery M, Hernandez-Avila C, Oncken C, et al. (2005). GABRA2 alleles moderate the subjective effects of alcohol, which are attenuated by finasteride. Neuropsychopharmacology 30:1193-1203.
31. Porjesz B, Almasy L, Edenberg HJ, Wang K, Chorlian DB, Foroud T, et al. (2002). Linkage disequilibrium between the beta frequency of the human EEG and a GABAA receptor gene locus. Proc Natl Acad Sci USA 99:3729-3733.
32. Prescott CA, Kendler KS (1999). Genetic and environmental contributions to alcohol abuse and dependence in a population-based sample of male twins. Am J Psychiatry 156:34-40.
33. Reich T, Edenberg HJ, Goate A, Williams JT, Rice JP, Van Eerdewegh P, et al. (1998). Genome-wide search for genes affecting the risk for alcohol dependence. Am J Med Genet 81:207-215.
34. Rudolph U, Crestani F, Benke D, Brunig I, Benson JA, Fritschy JM, et al. (1999). Benzodiazepine actions mediated by specific gamma-aminobutyric acid(A) receptor subtypes. Nature 401:796-800.
35. Sanna E, Mostallino MC, Busonero F, Talani G, Tranquilli S, Mameli M, et al. (2003). Changes in GABA(A) receptor gene expression associated with selective alterations in receptor function and pharmacology after ethanol withdrawal. J Neurosci 23:11711-11724.
36. Scheurich A, Muller MJ, Wetzel H, Anghelescu I, Klawe C, Ruppe A, et al. (2000). Reliability and validity of the German version of the European Addiction Severity Index (EuropASI). J Stud Alcohol 61:916-919.
37. Selzer ML (1971). The Michigan Alcoholism Screening Test: the quest for a new diagnostic instrument. Am J Psychiatry 127:1653-1658.
38. Shen YC, Fan JH, Edenberg HJ, Li TK, Cui YH, Wang YF, et al. (1997). Polymorphism of ADH and ALDH genes among four ethnic groups in China and effects upon the risk for alcoholism. Alcohol Clin Exp Res 21:1272-1277.
39. Sigvardsson S, Bohman M, Cloninger CR (1996). Replication of the Stockholm Adoption Study of Alcoholism. Confirmatory cross-fostering analysis. Arch Gen Psychiatry 53:681-687.
40. Song J, Koller DL, Foroud T, Carr K, Zhao J, Rice J, et al. (2003). Association of GABA(A) receptors and alcohol dependence and the effects of genetic imprinting. Am J Med Genet B Neuropsychiatr Genet 117:39-45.
41. Spitzer RL, Williams JBW, Gibbon M, First MB (1990). Structured clinical interview for DSM-III-R personality disorders (SCID-II). Washington, District of Columbia: American Psychiatric Press.
42. Tian H, Chen HJ, Cross TH, Edenberg HJ (2005). Alternative splicing and promoter use in the human GABRA2 gene. Brain Res Mol Brain Res 137:174-183.
43. Witkiewitz K, Marlatt GA (2004). Relapse prevention for alcohol and drug problems: that was Zen, this is Tao. Am Psychol 59:224-235.
44. Wittchen HU, Lachner G, Wunderlich U, Pfister H (1998). Test-retest reliability of the computerized DSM-IV version of the Munich-Composite International Diagnostic Interview (M-CIDI). Soc Psychiatry Psychiatr Epidemiol 33:568-578.