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Volumn 50, Issue 6, 2009, Pages 1258-1266

Signalling pathways in alcohol-induced liver inflammation

Author keywords

Kupffer cells; Macrophages; MAP kinases; TLRs; Transcription factors

Indexed keywords

ALCOHOL; CD14 ANTIGEN; EARLY GROWTH RESPONSE FACTOR 1; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 10; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; REACTIVE OXYGEN METABOLITE; STAT1 PROTEIN; STAT3 PROTEIN; TOLL LIKE RECEPTOR 4; TRANSCRIPTION FACTOR AP 1; TUMOR NECROSIS FACTOR ALPHA;

EID: 67349255858     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jhep.2009.03.007     Document Type: Review
Times cited : (404)

References (93)
  • 1
    • 3242692432 scopus 로고    scopus 로고
    • Recent advances in alcoholic liver disease III. Role of innate immune responses in alcoholic hepatitis
    • Hines I.N., and Wheeler M.D. Recent advances in alcoholic liver disease III. Role of innate immune responses in alcoholic hepatitis. Am J Physiol Gastrointest Liver Physiol 287 (2004) G310-G314
    • (2004) Am J Physiol Gastrointest Liver Physiol , vol.287
    • Hines, I.N.1    Wheeler, M.D.2
  • 2
    • 0034014905 scopus 로고    scopus 로고
    • Plasma endotoxin and serum cytokine levels in patients with alcoholic hepatitis: relation to severity of liver disturbance
    • Fujimoto M., Uemura M., Nakatani Y., Tsujita S., Hoppo K., Tamagawa T., et al. Plasma endotoxin and serum cytokine levels in patients with alcoholic hepatitis: relation to severity of liver disturbance. Alcohol Clin Exp Res 24 (2000) 48S-54S
    • (2000) Alcohol Clin Exp Res , vol.24
    • Fujimoto, M.1    Uemura, M.2    Nakatani, Y.3    Tsujita, S.4    Hoppo, K.5    Tamagawa, T.6
  • 3
    • 0024587645 scopus 로고
    • Increased tumor necrosis factor production by monocytes in alcoholic hepatitis
    • McClain C.J., and Cohen D.A. Increased tumor necrosis factor production by monocytes in alcoholic hepatitis. Hepatology 9 (1989) 349-351
    • (1989) Hepatology , vol.9 , pp. 349-351
    • McClain, C.J.1    Cohen, D.A.2
  • 4
    • 0026026639 scopus 로고
    • Circulating tumor necrosis factor, interleukin-1 and interleukin-6 concentrations in chronic alcoholic patients
    • Khoruts A., Stahnke L., McClain C.J., Logan G., and Allen J. Circulating tumor necrosis factor, interleukin-1 and interleukin-6 concentrations in chronic alcoholic patients. Hepatology 13 (1991) 267-276
    • (1991) Hepatology , vol.13 , pp. 267-276
    • Khoruts, A.1    Stahnke, L.2    McClain, C.J.3    Logan, G.4    Allen, J.5
  • 6
    • 37349108815 scopus 로고    scopus 로고
    • Abrogation of the antifibrotic effects of natural killer cells/interferon-gamma contributes to alcohol acceleration of liver fibrosis
    • Jeong W.I., Park O., and Gao B. Abrogation of the antifibrotic effects of natural killer cells/interferon-gamma contributes to alcohol acceleration of liver fibrosis. Gastroenterology 134 (2008) 248-258
    • (2008) Gastroenterology , vol.134 , pp. 248-258
    • Jeong, W.I.1    Park, O.2    Gao, B.3
  • 7
    • 12444341944 scopus 로고    scopus 로고
    • Toll-like receptors in innate immunity
    • Takeda K., and Akira S. Toll-like receptors in innate immunity. Int Immunol 17 (2005) 1-14
    • (2005) Int Immunol , vol.17 , pp. 1-14
    • Takeda, K.1    Akira, S.2
  • 8
    • 32944464648 scopus 로고    scopus 로고
    • Pathogen recognition and innate immunity
    • Akira S., Uematsu S., and Takeuchi O. Pathogen recognition and innate immunity. Cell 124 (2006) 783-801
    • (2006) Cell , vol.124 , pp. 783-801
    • Akira, S.1    Uematsu, S.2    Takeuchi, O.3
  • 9
    • 3242690772 scopus 로고    scopus 로고
    • Lipid A antagonist, lipid IVa, is distinct from lipid A in interaction with Toll-like receptor 4 (TLR4)-MD-2 and ligand-induced TLR4 oligomerization
    • Saitoh S., Akashi S., Yamada T., Tanimura N., Kobayashi M., Konno K., et al. Lipid A antagonist, lipid IVa, is distinct from lipid A in interaction with Toll-like receptor 4 (TLR4)-MD-2 and ligand-induced TLR4 oligomerization. Int Immunol 16 (2004) 961-969
    • (2004) Int Immunol , vol.16 , pp. 961-969
    • Saitoh, S.1    Akashi, S.2    Yamada, T.3    Tanimura, N.4    Kobayashi, M.5    Konno, K.6
  • 10
    • 0033574415 scopus 로고    scopus 로고
    • Toll-like receptor-4 mediates lipopolysaccharide-induced signal transduction
    • Chow J.C., Young D.W., Golenbock D.T., Christ W.J., and Gusovsky F. Toll-like receptor-4 mediates lipopolysaccharide-induced signal transduction. J Biol Chem 274 (1999) 10682-10692
    • (1999) J Biol Chem , vol.274 , pp. 10682-10692
    • Chow, J.C.1    Young, D.W.2    Golenbock, D.T.3    Christ, W.J.4    Gusovsky, F.5
  • 11
    • 0035834135 scopus 로고    scopus 로고
    • Secreted MD-2 is a large polymeric protein that efficiently confers lipopolysaccharide sensitivity to Toll-like receptor 4
    • Visintin A., Mazzoni A., Spitzer J.A., and Segal D.M. Secreted MD-2 is a large polymeric protein that efficiently confers lipopolysaccharide sensitivity to Toll-like receptor 4. Proc Natl Acad Sci USA 98 (2001) 12156-12161
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 12156-12161
    • Visintin, A.1    Mazzoni, A.2    Spitzer, J.A.3    Segal, D.M.4
  • 12
    • 0022462376 scopus 로고
    • Isolation of a lipopolysaccharide-binding acute phase reactant from rabbit serum
    • Tobias P.S., Soldau K., and Ulevitch R.J. Isolation of a lipopolysaccharide-binding acute phase reactant from rabbit serum. J Exp Med 164 (1986) 777-793
    • (1986) J Exp Med , vol.164 , pp. 777-793
    • Tobias, P.S.1    Soldau, K.2    Ulevitch, R.J.3
  • 13
    • 0024464813 scopus 로고
    • Lipopolysaccharide (LPS) binding protein opsonizes LPS-bearing particles for recognition by a novel receptor on macrophages
    • Wright S.D., Tobias P.S., Ulevitch R.J., and Ramos R.A. Lipopolysaccharide (LPS) binding protein opsonizes LPS-bearing particles for recognition by a novel receptor on macrophages. J Exp Med 170 (1989) 1231-1241
    • (1989) J Exp Med , vol.170 , pp. 1231-1241
    • Wright, S.D.1    Tobias, P.S.2    Ulevitch, R.J.3    Ramos, R.A.4
  • 14
    • 0025166114 scopus 로고
    • CD14, a receptor for complexes of lipopolysaccharide (LPS) and LPS binding protein
    • Wright S.D., Ramos R.A., Tobias P.S., Ulevitch R.J., and Mathison J.C. CD14, a receptor for complexes of lipopolysaccharide (LPS) and LPS binding protein. Science 249 (1990) 1431-1433
    • (1990) Science , vol.249 , pp. 1431-1433
    • Wright, S.D.1    Ramos, R.A.2    Tobias, P.S.3    Ulevitch, R.J.4    Mathison, J.C.5
  • 15
    • 20444366947 scopus 로고    scopus 로고
    • Adaptor usage and Toll-like receptor signaling specificity
    • Dunne A., and O'Neill L.A. Adaptor usage and Toll-like receptor signaling specificity. FEBS Lett 579 (2005) 3330-3335
    • (2005) FEBS Lett , vol.579 , pp. 3330-3335
    • Dunne, A.1    O'Neill, L.A.2
  • 17
    • 0033532629 scopus 로고    scopus 로고
    • MD-2, a molecule that confers lipopolysaccharide responsiveness on Toll-like receptor 4
    • Simazu R., Akashi S., Ogata H., Nagai Y., Fukodome K., Miyake K., et al. MD-2, a molecule that confers lipopolysaccharide responsiveness on Toll-like receptor 4. J Exp Med 189 (1999) 1777-1782
    • (1999) J Exp Med , vol.189 , pp. 1777-1782
    • Simazu, R.1    Akashi, S.2    Ogata, H.3    Nagai, Y.4    Fukodome, K.5    Miyake, K.6
  • 18
  • 19
    • 1642529500 scopus 로고    scopus 로고
    • Isolation of an endotoxin-MD-2 complex that produces Toll-like receptor 4-dependent cell activation of picomolar concentrations
    • Giovanni T.L., Teghanemt A., Zhang D., Coussens N.P., Dockstader W., Ramaswamy S., et al. Isolation of an endotoxin-MD-2 complex that produces Toll-like receptor 4-dependent cell activation of picomolar concentrations. Proc Natl Acad Sci USA 101 (2004) 4186-4191
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 4186-4191
    • Giovanni, T.L.1    Teghanemt, A.2    Zhang, D.3    Coussens, N.P.4    Dockstader, W.5    Ramaswamy, S.6
  • 20
    • 33751584426 scopus 로고    scopus 로고
    • Recombinant soluble forms of extracellular TLR4 domain and MD-2 inhibit lipopolysaccharide binding on cell surface and dampen lipopolysaccharide-induced pulmonary inflammation in mice
    • Mitsuzawa H., Nishitani C., Hyakushima N., Shimzu T., Sano H., Matsushima N., et al. Recombinant soluble forms of extracellular TLR4 domain and MD-2 inhibit lipopolysaccharide binding on cell surface and dampen lipopolysaccharide-induced pulmonary inflammation in mice. J Immunol 177 (2006) 8133-8139
    • (2006) J Immunol , vol.177 , pp. 8133-8139
    • Mitsuzawa, H.1    Nishitani, C.2    Hyakushima, N.3    Shimzu, T.4    Sano, H.5    Matsushima, N.6
  • 22
    • 47149105036 scopus 로고    scopus 로고
    • TLRs and adaptor molecules in liver disease: update
    • Seki E., and Brenner D.A. TLRs and adaptor molecules in liver disease: update. Hepatology 48 (2008) 322-335
    • (2008) Hepatology , vol.48 , pp. 322-335
    • Seki, E.1    Brenner, D.A.2
  • 23
    • 0031928131 scopus 로고    scopus 로고
    • Alcohol causes both tolerance and sensitization of rat Kupffer cells via mechanisms dependent on endotoxin
    • Enomoto N., Ikejima K., Bradford B., Rivera C., Kono H., Brenner D.A., et al. Alcohol causes both tolerance and sensitization of rat Kupffer cells via mechanisms dependent on endotoxin. Gastroenterology 115 (1998) 443-451
    • (1998) Gastroenterology , vol.115 , pp. 443-451
    • Enomoto, N.1    Ikejima, K.2    Bradford, B.3    Rivera, C.4    Kono, H.5    Brenner, D.A.6
  • 24
    • 0034950477 scopus 로고    scopus 로고
    • Toll-like receptor 4 is involved in the mechanism of early alcohol-induced liver injury in mice
    • Uesugi T., Froh M., Arteel G.E., Bradford B.U., and Thurman R.G. Toll-like receptor 4 is involved in the mechanism of early alcohol-induced liver injury in mice. Hepatology 34 (2001) 101-108
    • (2001) Hepatology , vol.34 , pp. 101-108
    • Uesugi, T.1    Froh, M.2    Arteel, G.E.3    Bradford, B.U.4    Thurman, R.G.5
  • 25
    • 0037087374 scopus 로고    scopus 로고
    • Role of lipopolysaccharide-binding protein in early alcohol-induced liver injury in mice
    • Uesugi T., Froh M., Arteel G.E., Bradford B.U., Wheller M.D., Gabele E., et al. Role of lipopolysaccharide-binding protein in early alcohol-induced liver injury in mice. J Immunol 168 (2002) 2963-2969
    • (2002) J Immunol , vol.168 , pp. 2963-2969
    • Uesugi, T.1    Froh, M.2    Arteel, G.E.3    Bradford, B.U.4    Wheller, M.D.5    Gabele, E.6
  • 26
  • 27
    • 21644472266 scopus 로고    scopus 로고
    • Increased lipopolysaccharide sensitivity in alcoholic fatty livers is independent of leptin deficiency and Toll-like receptor 4 (TLR4) or TLR2 mRNA expression
    • Romics Jr. L., Mandrekar P., Kodys K., Velayudham A., Drechsler Y., Dolganiuc A., et al. Increased lipopolysaccharide sensitivity in alcoholic fatty livers is independent of leptin deficiency and Toll-like receptor 4 (TLR4) or TLR2 mRNA expression. Alcohol Clin Exp Res 29 (2005) 1018-1026
    • (2005) Alcohol Clin Exp Res , vol.29 , pp. 1018-1026
    • Romics Jr., L.1    Mandrekar, P.2    Kodys, K.3    Velayudham, A.4    Drechsler, Y.5    Dolganiuc, A.6
  • 28
    • 0038185316 scopus 로고    scopus 로고
    • Toll-like receptor 4 mediates inflammatory signaling by bacterial lipopolysaccharide in human hepatic stellate cells
    • Paik Y.H., Schwabe R.F., Bataller R., Russo M.P., Jobin C., and Brenner D.A. Toll-like receptor 4 mediates inflammatory signaling by bacterial lipopolysaccharide in human hepatic stellate cells. Hepatology 37 (2003) 1043-1055
    • (2003) Hepatology , vol.37 , pp. 1043-1055
    • Paik, Y.H.1    Schwabe, R.F.2    Bataller, R.3    Russo, M.P.4    Jobin, C.5    Brenner, D.A.6
  • 29
    • 0029936091 scopus 로고    scopus 로고
    • Hepatic sinusoidal endothelial cell in alcoholemia and endotoxemia
    • Deaciuc I.V., and Spitzer J.J. Hepatic sinusoidal endothelial cell in alcoholemia and endotoxemia. Alcohol Clin Exp Res 20 (1996) 607-614
    • (1996) Alcohol Clin Exp Res , vol.20 , pp. 607-614
    • Deaciuc, I.V.1    Spitzer, J.J.2
  • 30
    • 0141625009 scopus 로고    scopus 로고
    • Recent insights into the role of the innate immune system in the development of alcoholic liver disease
    • Nagy L.E. Recent insights into the role of the innate immune system in the development of alcoholic liver disease. Exp Biol Med 228 (2003) 882-890
    • (2003) Exp Biol Med , vol.228 , pp. 882-890
    • Nagy, L.E.1
  • 31
    • 33646539166 scopus 로고    scopus 로고
    • Differential liver sensitization to Toll-like receptor pathways in mice with alcoholic fatty liver
    • Gustot T., Lemmers A., Moreno C., Nagy N., Quertinmont E., Nicaise C., et al. Differential liver sensitization to Toll-like receptor pathways in mice with alcoholic fatty liver. Hepatology 43 (2006) 989-1000
    • (2006) Hepatology , vol.43 , pp. 989-1000
    • Gustot, T.1    Lemmers, A.2    Moreno, C.3    Nagy, N.4    Quertinmont, E.5    Nicaise, C.6
  • 32
    • 54449092214 scopus 로고    scopus 로고
    • The critical role of Toll-like receptor 4 in alcoholic liver disease is independent of the common TLR adaptor, MyD88
    • Hritz I., Mandrekar P., Velayudham A., Catalano D., Dolganiuc A., Kurt-Jones E., et al. The critical role of Toll-like receptor 4 in alcoholic liver disease is independent of the common TLR adaptor, MyD88. Hepatology 48 (2008) 1224-1231
    • (2008) Hepatology , vol.48 , pp. 1224-1231
    • Hritz, I.1    Mandrekar, P.2    Velayudham, A.3    Catalano, D.4    Dolganiuc, A.5    Kurt-Jones, E.6
  • 33
    • 0141959224 scopus 로고    scopus 로고
    • LPS-TLR4 signaling to IRF-3 3/7 and NF-kappaB involves the Toll adaptors TRAM and TRIF
    • Fitzgerald K.A., Rowe D.C., Barnes B.J., Caffrey D.R., Visintin A., Latz E., et al. LPS-TLR4 signaling to IRF-3 3/7 and NF-kappaB involves the Toll adaptors TRAM and TRIF. J Exp Med 198 (2003) 1043-1055
    • (2003) J Exp Med , vol.198 , pp. 1043-1055
    • Fitzgerald, K.A.1    Rowe, D.C.2    Barnes, B.J.3    Caffrey, D.R.4    Visintin, A.5    Latz, E.6
  • 34
    • 0035889228 scopus 로고    scopus 로고
    • Lipopolysaccharide stimulates the MyD88-independent pathway and results in activation of IFN-regulatory factor 3 and the expression of a subset of lipopolysaccharide-inducible genes
    • Kawai T., Takeuchi O., Fujita T., Inoue J., Mühlradt P.F., Sato S., et al. Lipopolysaccharide stimulates the MyD88-independent pathway and results in activation of IFN-regulatory factor 3 and the expression of a subset of lipopolysaccharide-inducible genes. J Immunol 167 (2001) 5887-5894
    • (2001) J Immunol , vol.167 , pp. 5887-5894
    • Kawai, T.1    Takeuchi, O.2    Fujita, T.3    Inoue, J.4    Mühlradt, P.F.5    Sato, S.6
  • 35
    • 0742324860 scopus 로고    scopus 로고
    • TLR signaling pathways
    • Takeda K., and Akira S. TLR signaling pathways. Semin Immunol 16 (2004) 3-9
    • (2004) Semin Immunol , vol.16 , pp. 3-9
    • Takeda, K.1    Akira, S.2
  • 36
    • 0043176281 scopus 로고    scopus 로고
    • Role of adaptor TRIF in the MyD88-independent Toll-like receptor signaling pathway
    • Yamamoto M., Sata S., Hemmi H., Hoshino K., Kaisho T., Sanjo H., et al. Role of adaptor TRIF in the MyD88-independent Toll-like receptor signaling pathway. Science 301 (2003) 640-643
    • (2003) Science , vol.301 , pp. 640-643
    • Yamamoto, M.1    Sata, S.2    Hemmi, H.3    Hoshino, K.4    Kaisho, T.5    Sanjo, H.6
  • 37
    • 0034597711 scopus 로고    scopus 로고
    • Tolerance and sensitization to endotoxin in Kupffer cells caused by acute ethanol involve interleukin-1 receptor-associated kinase
    • Yamashina S., Wheeler M.D., Rusyn I., Ikejima K., Sato N., and Thurman R.G. Tolerance and sensitization to endotoxin in Kupffer cells caused by acute ethanol involve interleukin-1 receptor-associated kinase. Biochem Biophys Res Commun 277 (2000) 686-690
    • (2000) Biochem Biophys Res Commun , vol.277 , pp. 686-690
    • Yamashina, S.1    Wheeler, M.D.2    Rusyn, I.3    Ikejima, K.4    Sato, N.5    Thurman, R.G.6
  • 38
    • 33744901148 scopus 로고    scopus 로고
    • TLR2- and TLR4-mediated signals determine attenuation or augmentation of inflammation by acute alcohol in monocytes
    • Oak S., Mandrekar P., Catalano D., Kodys K., and Szabo G. TLR2- and TLR4-mediated signals determine attenuation or augmentation of inflammation by acute alcohol in monocytes. J Immunol 176 (2006) 7628-7635
    • (2006) J Immunol , vol.176 , pp. 7628-7635
    • Oak, S.1    Mandrekar, P.2    Catalano, D.3    Kodys, K.4    Szabo, G.5
  • 39
    • 19344375848 scopus 로고    scopus 로고
    • Acute exposure to ethanol affects Toll-like receptor signaling and subsequent responses: an overview of recent studies
    • Pruett S.B., Zheng Q., Fan R., Matthews K., and Schwab C. Acute exposure to ethanol affects Toll-like receptor signaling and subsequent responses: an overview of recent studies. Alcohol 33 (2004) 235-239
    • (2004) Alcohol , vol.33 , pp. 235-239
    • Pruett, S.B.1    Zheng, Q.2    Fan, R.3    Matthews, K.4    Schwab, C.5
  • 40
    • 51549118941 scopus 로고    scopus 로고
    • TRIF and IRF-3 binding to the TNF promoter results in macrophage TNF dysregulation and steatosis induced by chronic ethanol
    • Zhao X.J., Dong Q., Bindas J., Piganelli J.D., Magill A., Reiser J., et al. TRIF and IRF-3 binding to the TNF promoter results in macrophage TNF dysregulation and steatosis induced by chronic ethanol. J Immunol 181 (2008) 3049-3056
    • (2008) J Immunol , vol.181 , pp. 3049-3056
    • Zhao, X.J.1    Dong, Q.2    Bindas, J.3    Piganelli, J.D.4    Magill, A.5    Reiser, J.6
  • 41
    • 0036861681 scopus 로고    scopus 로고
    • Acute alcohol inhibits the induction of nuclear regulatory factor kappa B activation through CD14/Toll-like receptor 4, interleukin-1, and tumor necrosis factor receptors: a common mechanism independent of inhibitory kappa B alpha degradation?
    • Mandrekar P., Dolganiuc A., Bellerose G., Kodys K., Romics L., Nizamani R., et al. Acute alcohol inhibits the induction of nuclear regulatory factor kappa B activation through CD14/Toll-like receptor 4, interleukin-1, and tumor necrosis factor receptors: a common mechanism independent of inhibitory kappa B alpha degradation?. Alcohol Clin Exp Res 26 (2002) 1609-1614
    • (2002) Alcohol Clin Exp Res , vol.26 , pp. 1609-1614
    • Mandrekar, P.1    Dolganiuc, A.2    Bellerose, G.3    Kodys, K.4    Romics, L.5    Nizamani, R.6
  • 42
    • 33644781712 scopus 로고    scopus 로고
    • Moderate alcohol intake in humans attenuates monocyte inflammatory responses: inhibition of nuclear regulatory factor kappa B and induction of interleukin 10
    • Mandrekar P., Catalano D., White B., and Szabo G. Moderate alcohol intake in humans attenuates monocyte inflammatory responses: inhibition of nuclear regulatory factor kappa B and induction of interleukin 10. Alcohol Clin Exp Res 30 (2006) 135-139
    • (2006) Alcohol Clin Exp Res , vol.30 , pp. 135-139
    • Mandrekar, P.1    Catalano, D.2    White, B.3    Szabo, G.4
  • 43
    • 0033802236 scopus 로고    scopus 로고
    • NADPH oxidase-derived free radicals are key oxidants in alcohol-induced liver disease
    • Kono H., Rusyn I., Yin M., Gäbele E., Yamashina S., Dikalova A., et al. NADPH oxidase-derived free radicals are key oxidants in alcohol-induced liver disease. J Clin Invest 106 (2000) 867-872
    • (2000) J Clin Invest , vol.106 , pp. 867-872
    • Kono, H.1    Rusyn, I.2    Yin, M.3    Gäbele, E.4    Yamashina, S.5    Dikalova, A.6
  • 44
    • 33747061494 scopus 로고    scopus 로고
    • Enhanced LPS-stimulated ERK 1/2 activation and TNF alpha secretion by rat Kupffer cells after chronic ethanol feeding is mediated via increased production of reactive oxygen species (ROS) by NADPH oxidase
    • Thakur V., McMullen M.R., Wang Q., and Nagy L.E. Enhanced LPS-stimulated ERK 1/2 activation and TNF alpha secretion by rat Kupffer cells after chronic ethanol feeding is mediated via increased production of reactive oxygen species (ROS) by NADPH oxidase. Hepatology 42 (2005) 571A
    • (2005) Hepatology , vol.42
    • Thakur, V.1    McMullen, M.R.2    Wang, Q.3    Nagy, L.E.4
  • 45
    • 4644350365 scopus 로고    scopus 로고
    • Cutting edge: direct interaction of TLR4 with NADPH oxidase 4 isozyme is essential for lipopolysaccharide-induced production of reactive oxygen species and activation of NF-kappa B
    • Park H.S., Jung H.Y., Park E.Y., Kim J., Lee W.J., and Bae Y.S. Cutting edge: direct interaction of TLR4 with NADPH oxidase 4 isozyme is essential for lipopolysaccharide-induced production of reactive oxygen species and activation of NF-kappa B. J Immunol 173 (2004) 3589-3593
    • (2004) J Immunol , vol.173 , pp. 3589-3593
    • Park, H.S.1    Jung, H.Y.2    Park, E.Y.3    Kim, J.4    Lee, W.J.5    Bae, Y.S.6
  • 46
    • 58149333718 scopus 로고    scopus 로고
    • High glucose induces Toll-like receptor expression in human monocytes: mechanisms of activation
    • Dasu M.R., Devaraj S., Ling Z., Hwang D.H., and Jialal I. High glucose induces Toll-like receptor expression in human monocytes: mechanisms of activation. Diabetes 57 (2008) 3090-3098
    • (2008) Diabetes , vol.57 , pp. 3090-3098
    • Dasu, M.R.1    Devaraj, S.2    Ling, Z.3    Hwang, D.H.4    Jialal, I.5
  • 47
    • 0036294518 scopus 로고    scopus 로고
    • Dilinoleoylphosphatidylcholine decreases LPS-induced TNF-alpha generation in Kupffer cells of ethanol-fed rats: respective roles of MAPKs and NF-kappaB
    • Cao Q., Mak K.M., and Leiber C.S. Dilinoleoylphosphatidylcholine decreases LPS-induced TNF-alpha generation in Kupffer cells of ethanol-fed rats: respective roles of MAPKs and NF-kappaB. Biochem Biophys Res Comm 294 (2002) 849-853
    • (2002) Biochem Biophys Res Comm , vol.294 , pp. 849-853
    • Cao, Q.1    Mak, K.M.2    Leiber, C.S.3
  • 48
    • 0032771055 scopus 로고    scopus 로고
    • Regulation of inducible gene expression by the transcription factor NF-kappaB
    • Ghosh S. Regulation of inducible gene expression by the transcription factor NF-kappaB. Immunol Res 19 (1999) 183-189
    • (1999) Immunol Res , vol.19 , pp. 183-189
    • Ghosh, S.1
  • 49
    • 0035068683 scopus 로고    scopus 로고
    • Adenoviral gene delivery can inactivate Kupffer cells: role of oxidants in NF-kappaB activation and cytokine production
    • Wheeler M.D., Yamashina S., Froh M., Rusyn I., and Thurman R.G. Adenoviral gene delivery can inactivate Kupffer cells: role of oxidants in NF-kappaB activation and cytokine production. J Leukoc Biol 69 (2001) 622-630
    • (2001) J Leukoc Biol , vol.69 , pp. 622-630
    • Wheeler, M.D.1    Yamashina, S.2    Froh, M.3    Rusyn, I.4    Thurman, R.G.5
  • 50
    • 0032862559 scopus 로고    scopus 로고
    • Activation of nuclear factor kappa B and cytokine imbalance in experimental alcoholic liver disease in the rat
    • Nanji A.A., Jokelainen K., Rahemtulla A., Miao L., Fogt F., Matsumoto H., et al. Activation of nuclear factor kappa B and cytokine imbalance in experimental alcoholic liver disease in the rat. Hepatology 30 (1999) 934-943
    • (1999) Hepatology , vol.30 , pp. 934-943
    • Nanji, A.A.1    Jokelainen, K.2    Rahemtulla, A.3    Miao, L.4    Fogt, F.5    Matsumoto, H.6
  • 51
    • 0033806903 scopus 로고    scopus 로고
    • Increased monocyte nuclear factor-kappaB activation and tumor necrosis factor production in alcoholic hepatitis
    • Hill D.B., Barve S., Joshi-Barve S., and McClain C. Increased monocyte nuclear factor-kappaB activation and tumor necrosis factor production in alcoholic hepatitis. J Lab Clin Med 135 (2000) 387-395
    • (2000) J Lab Clin Med , vol.135 , pp. 387-395
    • Hill, D.B.1    Barve, S.2    Joshi-Barve, S.3    McClain, C.4
  • 52
    • 0032742640 scopus 로고    scopus 로고
    • Inhibition of lipopolysaccharide-mediated NFkappaB activation by ethanol in human monocytes
    • Mandrekar P., Catalano D., and Szabo G. Inhibition of lipopolysaccharide-mediated NFkappaB activation by ethanol in human monocytes. Int Immunol 11 (1999) 1781-1790
    • (1999) Int Immunol , vol.11 , pp. 1781-1790
    • Mandrekar, P.1    Catalano, D.2    Szabo, G.3
  • 53
    • 0030885957 scopus 로고    scopus 로고
    • Alcohol-induced regulation of nuclear regulatory factor-kappa beta in human monocytes
    • Mandrekar P., Catalano D., and Szabo G. Alcohol-induced regulation of nuclear regulatory factor-kappa beta in human monocytes. Alcohol Clin Exp Res 21 (1997) 988-994
    • (1997) Alcohol Clin Exp Res , vol.21 , pp. 988-994
    • Mandrekar, P.1    Catalano, D.2    Szabo, G.3
  • 54
    • 0025720735 scopus 로고
    • The role of Jun, Fos and the AP-1 complex in cell proliferation and transformation
    • Angel P., and Karin M. The role of Jun, Fos and the AP-1 complex in cell proliferation and transformation. Biochem Biophys Acta 1072 (1991) 129-157
    • (1991) Biochem Biophys Acta , vol.1072 , pp. 129-157
    • Angel, P.1    Karin, M.2
  • 55
    • 0035971493 scopus 로고    scopus 로고
    • AP-1 in cell proliferation and survival
    • Shaulian E., and Karin M. AP-1 in cell proliferation and survival. Oncogene 20 (2001) 2390-2400
    • (2001) Oncogene , vol.20 , pp. 2390-2400
    • Shaulian, E.1    Karin, M.2
  • 56
    • 0037424240 scopus 로고    scopus 로고
    • Upregulation of CD14 in liver due to acute ethanol involves oxidant-dependent AP-1 pathway
    • Wheeler M.D., and Thurman R.G. Upregulation of CD14 in liver due to acute ethanol involves oxidant-dependent AP-1 pathway. J Biol Chem 278 (2003) 8345-8351
    • (2003) J Biol Chem , vol.278 , pp. 8345-8351
    • Wheeler, M.D.1    Thurman, R.G.2
  • 57
    • 34548418895 scopus 로고    scopus 로고
    • Acute alcohol activates STAT3, AP-1, and Sp-1 transcription factors via the family of Src kinases to promote IL-10 production in human monocytes
    • Norkina O., Dolganiuc A., Shapiro T., Kodys K., Mandrekar P., and Szabo G. Acute alcohol activates STAT3, AP-1, and Sp-1 transcription factors via the family of Src kinases to promote IL-10 production in human monocytes. J Leukoc Biol 82 (2007) 752-762
    • (2007) J Leukoc Biol , vol.82 , pp. 752-762
    • Norkina, O.1    Dolganiuc, A.2    Shapiro, T.3    Kodys, K.4    Mandrekar, P.5    Szabo, G.6
  • 58
    • 0028360492 scopus 로고
    • Acetaldehyde induces c-Fos and c-Jun proto-oncogenes in fat-storing cell cultures through protein kinase C activation
    • Casini A., Galli G., Salzano R., Ceni E., Franceschelli F., Rotella C.M., et al. Acetaldehyde induces c-Fos and c-Jun proto-oncogenes in fat-storing cell cultures through protein kinase C activation. Alcohol Alcohol 29 (1994) 303-314
    • (1994) Alcohol Alcohol , vol.29 , pp. 303-314
    • Casini, A.1    Galli, G.2    Salzano, R.3    Ceni, E.4    Franceschelli, F.5    Rotella, C.M.6
  • 59
    • 0036086233 scopus 로고    scopus 로고
    • ERK1/2 and Egr-1 contribute to increased TNF-alpha production in rat Kupffer cells after chronic ethanol feeding
    • Kishore R., Hill J.R., McMullen M.R., Frenkel J., and Nagy L.E. ERK1/2 and Egr-1 contribute to increased TNF-alpha production in rat Kupffer cells after chronic ethanol feeding. Am J Physiol Gastrointest Liver Physiol 282 (2002) G6-G15
    • (2002) Am J Physiol Gastrointest Liver Physiol , vol.282
    • Kishore, R.1    Hill, J.R.2    McMullen, M.R.3    Frenkel, J.4    Nagy, L.E.5
  • 60
    • 0029161198 scopus 로고
    • Early growth response protein 1 (Egr-1) prototype of a zinc-finger family of transcription factors
    • Gashler A., and Sukhatme V.P. Early growth response protein 1 (Egr-1) prototype of a zinc-finger family of transcription factors. Prog Nucleic Acid Res Mol Biol 50 (1995) 191-224
    • (1995) Prog Nucleic Acid Res Mol Biol , vol.50 , pp. 191-224
    • Gashler, A.1    Sukhatme, V.P.2
  • 61
    • 0034533374 scopus 로고    scopus 로고
    • Egr-1, a master switch coordinating upregulation of divergent gene families underlying ischemic stress
    • Yan S.F., Fujita T., Lu J., Okada K., Zou Y.S., Mackman N., et al. Egr-1, a master switch coordinating upregulation of divergent gene families underlying ischemic stress. Nat Med 6 (2000) 1355-1361
    • (2000) Nat Med , vol.6 , pp. 1355-1361
    • Yan, S.F.1    Fujita, T.2    Lu, J.3    Okada, K.4    Zou, Y.S.5    Mackman, N.6
  • 62
    • 32044473030 scopus 로고    scopus 로고
    • Ethanol-induced liver injury: potential roles for egr-1
    • Pritchard M.T., and Nagy L.E. Ethanol-induced liver injury: potential roles for egr-1. Alcohol Clin Exp Res 29 (2005) 146S-150S
    • (2005) Alcohol Clin Exp Res , vol.29
    • Pritchard, M.T.1    Nagy, L.E.2
  • 63
    • 20444477804 scopus 로고    scopus 로고
    • Early growth response-1 transcription factor is essential for ethanol-induced fatty liver injury in mice
    • McMullen M.R., Pritchard M.T., Wang Q., Millward C.A., Croniger C.M., and Nagy L.E. Early growth response-1 transcription factor is essential for ethanol-induced fatty liver injury in mice. Gastroenterology 128 (2005) 2066-2076
    • (2005) Gastroenterology , vol.128 , pp. 2066-2076
    • McMullen, M.R.1    Pritchard, M.T.2    Wang, Q.3    Millward, C.A.4    Croniger, C.M.5    Nagy, L.E.6
  • 64
    • 0028234529 scopus 로고
    • Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins
    • Darnell Jr. J.E., Kerr I.M., and Stark G.R. Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. Science 264 (1994) 1415-1421
    • (1994) Science , vol.264 , pp. 1415-1421
    • Darnell Jr., J.E.1    Kerr, I.M.2    Stark, G.R.3
  • 65
    • 0037138370 scopus 로고    scopus 로고
    • Signaling through the JAK/STAT pathway, recent advances and future challenges
    • Kisseleva T., Bhattacharya S., Braunstein J., and Schindler C.W. Signaling through the JAK/STAT pathway, recent advances and future challenges. Gene 285 (2002) 1-24
    • (2002) Gene , vol.285 , pp. 1-24
    • Kisseleva, T.1    Bhattacharya, S.2    Braunstein, J.3    Schindler, C.W.4
  • 67
    • 50849134632 scopus 로고    scopus 로고
    • Acute alcohol intake induces SOCS1 and SOCS3 and inhibits cytokine-induced STAT1 and STAT3 signaling in human monocytes
    • Norkina O., Dolganiuc A., Catalano D., Kodys K., Mandrekar P., Syed A., et al. Acute alcohol intake induces SOCS1 and SOCS3 and inhibits cytokine-induced STAT1 and STAT3 signaling in human monocytes. Alcohol Clin Exp Res 32 (2008) 1565-1573
    • (2008) Alcohol Clin Exp Res , vol.32 , pp. 1565-1573
    • Norkina, O.1    Dolganiuc, A.2    Catalano, D.3    Kodys, K.4    Mandrekar, P.5    Syed, A.6
  • 68
    • 0034971511 scopus 로고    scopus 로고
    • Ethanol inhibits the JAK-STAT signaling pathway in fresh isolated rat hepatocytes but not in cultured hepatocytes or HepG2 cells: evidence for a lack of involvement of ethanol metabolism
    • Chen J., Clemens D.L., Cederbaum A.I., and Gao B. Ethanol inhibits the JAK-STAT signaling pathway in fresh isolated rat hepatocytes but not in cultured hepatocytes or HepG2 cells: evidence for a lack of involvement of ethanol metabolism. Clin Biochem 34 (2001) 203-209
    • (2001) Clin Biochem , vol.34 , pp. 203-209
    • Chen, J.1    Clemens, D.L.2    Cederbaum, A.I.3    Gao, B.4
  • 69
    • 34447284943 scopus 로고    scopus 로고
    • Liver regeneration is suppressed in alcoholic cirrhosis: correlation with decreased STAT3 activation
    • Horiguchi N., Ishac E.J., and Gao B. Liver regeneration is suppressed in alcoholic cirrhosis: correlation with decreased STAT3 activation. Alcohol 41 (2007) 271-280
    • (2007) Alcohol , vol.41 , pp. 271-280
    • Horiguchi, N.1    Ishac, E.J.2    Gao, B.3
  • 70
    • 41349098793 scopus 로고    scopus 로고
    • Cell type-dependent pro- and anti-inflammatory role of signal transducer and activator of transcription 3 in alcoholic liver injury
    • Horiguchi N., Wang L., Mukhopadhyay P., Park O., Jeong W.I., Lafdil F., et al. Cell type-dependent pro- and anti-inflammatory role of signal transducer and activator of transcription 3 in alcoholic liver injury. Gastroenterology 134 (2008) 1148-1158
    • (2008) Gastroenterology , vol.134 , pp. 1148-1158
    • Horiguchi, N.1    Wang, L.2    Mukhopadhyay, P.3    Park, O.4    Jeong, W.I.5    Lafdil, F.6
  • 71
    • 0030858764 scopus 로고    scopus 로고
    • Lipopolysaccharide induction of the tumor necrosis factor-alpha promoter in human monocytic cells: regulation by Egr-1, c-jun and NF-kappaB transcription factors
    • Yao J., Mackman N., Edgington T.S., and Fan S.T. Lipopolysaccharide induction of the tumor necrosis factor-alpha promoter in human monocytic cells: regulation by Egr-1, c-jun and NF-kappaB transcription factors. J Biol Chem 272 (1997) 17795-17801
    • (1997) J Biol Chem , vol.272 , pp. 17795-17801
    • Yao, J.1    Mackman, N.2    Edgington, T.S.3    Fan, S.T.4
  • 72
    • 0037177899 scopus 로고    scopus 로고
    • Chronic ethanol increases lipopolysaccharide stimulated Egr-1 expression in RAW 264.7 macrophages: contribution to enhanced tumor necrosis factor alpha production
    • Shi L., Kishore R., McMullen M.R., Frenkel J., and Nagy L.E. Chronic ethanol increases lipopolysaccharide stimulated Egr-1 expression in RAW 264.7 macrophages: contribution to enhanced tumor necrosis factor alpha production. J Biol Chem 277 (2002) 14777-14785
    • (2002) J Biol Chem , vol.277 , pp. 14777-14785
    • Shi, L.1    Kishore, R.2    McMullen, M.R.3    Frenkel, J.4    Nagy, L.E.5
  • 73
    • 0035834684 scopus 로고    scopus 로고
    • Stabilization of tumor necrosis factor alpha mRNA by chronic ethanol: role of A + U-rich elements and p38 mitogen-activated protein kinase signaling pathways
    • Kishore R., McMullen M.R., and Nagy L.E. Stabilization of tumor necrosis factor alpha mRNA by chronic ethanol: role of A + U-rich elements and p38 mitogen-activated protein kinase signaling pathways. J Biol Chem 276 (2001) 41930-41937
    • (2001) J Biol Chem , vol.276 , pp. 41930-41937
    • Kishore, R.1    McMullen, M.R.2    Nagy, L.E.3
  • 74
    • 0034816062 scopus 로고    scopus 로고
    • Mitogen-activated protein kinase p38 controls the expression and posttranslational modification of tristetraprolin, a regulator of tumor necrosis factor alpha mRNA stability
    • Mahtani K.R., Brook M., Dean J.L., Sully G., Saklatvala J., and Clark A.R. Mitogen-activated protein kinase p38 controls the expression and posttranslational modification of tristetraprolin, a regulator of tumor necrosis factor alpha mRNA stability. Mol Cell Biol 21 (2001) 6461-6469
    • (2001) Mol Cell Biol , vol.21 , pp. 6461-6469
    • Mahtani, K.R.1    Brook, M.2    Dean, J.L.3    Sully, G.4    Saklatvala, J.5    Clark, A.R.6
  • 75
    • 33746870415 scopus 로고    scopus 로고
    • Heme oxygenase-1 mediates the anti-inflammatory effects of acute alcohol on IL-10 induction involving p38 MAPK activation in monocytes
    • Drechsler Y., Dolganiuc A., Norkina O., Romics L., Li W., Kodys K., et al. Heme oxygenase-1 mediates the anti-inflammatory effects of acute alcohol on IL-10 induction involving p38 MAPK activation in monocytes. J Immunol 177 (2006) 2592-2600
    • (2006) J Immunol , vol.177 , pp. 2592-2600
    • Drechsler, Y.1    Dolganiuc, A.2    Norkina, O.3    Romics, L.4    Li, W.5    Kodys, K.6
  • 76
    • 10844223612 scopus 로고    scopus 로고
    • In vivo ethanol exposure down-regulations TLR2-, TLR4-, and TLR9-mediated macrophage inflammatory response by limiting p38 and ERK1/2 activation
    • Goral J., and Kovacs E.J. In vivo ethanol exposure down-regulations TLR2-, TLR4-, and TLR9-mediated macrophage inflammatory response by limiting p38 and ERK1/2 activation. J Immunol 174 (2005) 456-463
    • (2005) J Immunol , vol.174 , pp. 456-463
    • Goral, J.1    Kovacs, E.J.2
  • 77
    • 4644248469 scopus 로고    scopus 로고
    • S-adenosylhomocysteine sensitizes to TNF-alpha hepatotoxicity in mice and liver cells: a possible etiological factor in alcoholic liver disease
    • Song Z., Zhou Z., Uriarte S., Wang S., Kang Y.J., Chen T., et al. S-adenosylhomocysteine sensitizes to TNF-alpha hepatotoxicity in mice and liver cells: a possible etiological factor in alcoholic liver disease. Hepatology 40 (2004) 989-997
    • (2004) Hepatology , vol.40 , pp. 989-997
    • Song, Z.1    Zhou, Z.2    Uriarte, S.3    Wang, S.4    Kang, Y.J.5    Chen, T.6
  • 80
    • 0032185432 scopus 로고    scopus 로고
    • Mechanisms of hepatic toxicity. III. Alcoholic liver injury involves activation of Kupffer cells by endotoxin
    • Thurman R.G. Mechanisms of hepatic toxicity. III. Alcoholic liver injury involves activation of Kupffer cells by endotoxin. Am J Physiol 275 (1998) G605-G611
    • (1998) Am J Physiol , vol.275
    • Thurman, R.G.1
  • 81
    • 0037386110 scopus 로고    scopus 로고
    • Anti-tumor necrosis factor-alpha monoclonal antibody therapy in severe alcoholic hepatitis
    • Tilg H., Jalan R., Kaser A., Davies N.A., Offner F.A., Hodges S.I., et al. Anti-tumor necrosis factor-alpha monoclonal antibody therapy in severe alcoholic hepatitis. J Hepatol 38 (2003) 419-425
    • (2003) J Hepatol , vol.38 , pp. 419-425
    • Tilg, H.1    Jalan, R.2    Kaser, A.3    Davies, N.A.4    Offner, F.A.5    Hodges, S.I.6
  • 82
    • 0030716183 scopus 로고    scopus 로고
    • Antibodies to tumor necrosis factor alpha attenuate hepatic necrosis and inflammation caused by chronic exposure to ethanol in the rat
    • Imuro Y., Gallucci R.M., Luster M.I., Kono H., and Thurman R.G. Antibodies to tumor necrosis factor alpha attenuate hepatic necrosis and inflammation caused by chronic exposure to ethanol in the rat. Hepatology 26 (1997) 1530-1537
    • (1997) Hepatology , vol.26 , pp. 1530-1537
    • Imuro, Y.1    Gallucci, R.M.2    Luster, M.I.3    Kono, H.4    Thurman, R.G.5
  • 83
    • 0032835529 scopus 로고    scopus 로고
    • Essential role of tumor necrosis factor alpha in alcohol-induced liver injury in mice
    • Yin M., Wheeler M.D., Kono H., Bradford B.U., Gallucci R.M., Luster M.I., et al. Essential role of tumor necrosis factor alpha in alcohol-induced liver injury in mice. Gastroenterology 117 (1999) 942-952
    • (1999) Gastroenterology , vol.117 , pp. 942-952
    • Yin, M.1    Wheeler, M.D.2    Kono, H.3    Bradford, B.U.4    Gallucci, R.M.5    Luster, M.I.6
  • 85
    • 52949133396 scopus 로고    scopus 로고
    • Fat diet and alcohol-induced steatohepatitis after LPS challenge in mice: role of bioactive TNF and Th1 type cytokines
    • Olleros M.L., Martin M.L., Vesin D., Fotio A.L., Santiago-Rober M.L., Rubbia-Brandt L., et al. Fat diet and alcohol-induced steatohepatitis after LPS challenge in mice: role of bioactive TNF and Th1 type cytokines. Cytokine 44 (2008) 118-125
    • (2008) Cytokine , vol.44 , pp. 118-125
    • Olleros, M.L.1    Martin, M.L.2    Vesin, D.3    Fotio, A.L.4    Santiago-Rober, M.L.5    Rubbia-Brandt, L.6
  • 86
    • 7044284788 scopus 로고    scopus 로고
    • Regulation and role of transforming growth factor-beta in immune tolerance induction and inflammation
    • Schmidt-Weber C.B., and Blaser K. Regulation and role of transforming growth factor-beta in immune tolerance induction and inflammation. Curr Opin Immunol 16 (2004) 709-716
    • (2004) Curr Opin Immunol , vol.16 , pp. 709-716
    • Schmidt-Weber, C.B.1    Blaser, K.2
  • 87
    • 0038283161 scopus 로고    scopus 로고
    • Interleukin-10 therapy - review of a new approach
    • Asadullah K., Sterry W., and Volk H.D. Interleukin-10 therapy - review of a new approach. Pharmacol Rev 55 (2003) 241-269
    • (2003) Pharmacol Rev , vol.55 , pp. 241-269
    • Asadullah, K.1    Sterry, W.2    Volk, H.D.3
  • 88
    • 20644450804 scopus 로고    scopus 로고
    • Negative regulation of Toll-like receptor-mediated immune responses
    • Liew F.Y., Xu D., Brint E.K., and Oneill L.A. Negative regulation of Toll-like receptor-mediated immune responses. Nat Rev Immunol 5 (2005) 446-458
    • (2005) Nat Rev Immunol , vol.5 , pp. 446-458
    • Liew, F.Y.1    Xu, D.2    Brint, E.K.3    Oneill, L.A.4
  • 90
    • 33645804223 scopus 로고    scopus 로고
    • Adiponectin normalizes LPS-stimulated TNF-alpha production by rat Kupffer cells after chronic ethanol feeding
    • Thakur V., Prtichard M.T., McMullen M.R., and Nagy L.E. Adiponectin normalizes LPS-stimulated TNF-alpha production by rat Kupffer cells after chronic ethanol feeding. Am J Physiol Gastrointest Liver Physiol 290 (2006) G998-G1007
    • (2006) Am J Physiol Gastrointest Liver Physiol , vol.290
    • Thakur, V.1    Prtichard, M.T.2    McMullen, M.R.3    Nagy, L.E.4
  • 91
    • 40749111945 scopus 로고    scopus 로고
    • Mechanisms for the anti-inflammatory effects of adiponectin in macrophages
    • Huang H., Park P.H., McMullen M.R., and Nagy L.E. Mechanisms for the anti-inflammatory effects of adiponectin in macrophages. J Gastroenterol Hepatol 23 (2008) S850-S853
    • (2008) J Gastroenterol Hepatol , vol.23
    • Huang, H.1    Park, P.H.2    McMullen, M.R.3    Nagy, L.E.4
  • 92
    • 0030198906 scopus 로고    scopus 로고
    • Human monocyte IL-10 production is increased by acute ethanol treatment
    • Mandrekar P., Catalano D., Girouard L., and Szabo G. Human monocyte IL-10 production is increased by acute ethanol treatment. Cytokine 8 (1996) 567-577
    • (1996) Cytokine , vol.8 , pp. 567-577
    • Mandrekar, P.1    Catalano, D.2    Girouard, L.3    Szabo, G.4
  • 93
    • 0029787963 scopus 로고    scopus 로고
    • Regulation of human monocyte functions by acute ethanol treatment: decreased tumor necrosis factor-alpha, interleukin-1 beta and elevated interleukin-10, and transforming growth factor-beta production
    • Szabo G., Mandrekar P., Girouard L., and Catalano D. Regulation of human monocyte functions by acute ethanol treatment: decreased tumor necrosis factor-alpha, interleukin-1 beta and elevated interleukin-10, and transforming growth factor-beta production. Alcohol Clin Exp Res 20 (1996) 900-907
    • (1996) Alcohol Clin Exp Res , vol.20 , pp. 900-907
    • Szabo, G.1    Mandrekar, P.2    Girouard, L.3    Catalano, D.4


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