Association between alcoholism and γ-amino butyric acid α2 receptor subtype in a Russian population

Alcoholism: Clinical and Experimental Research

Volumn 29, Issue 4, 2005, Pages 493-498

  Lappalainen, Jaakko ^a,b,e   Krupitsky, Evgeny ^c   Remizov, Mikhail ^c   Pchelina, Sofia ^c   Taraskina, Anastaisa ^c   Zvartau, Edwin ^c   Somberg, Lucia K ^a,b   Covault, Jonathan ^d   Kranzler, Henry R ^d   Krystal, John H ^a,b   Gelernter, Joel ^a,b  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VA CONNECTICUT HEALTHCARE SYSTEM   (United States)

^c PAVLOV FIRST SAINT PETERSBURG STATE MEDICAL UNIVERSITY   (Russian Federation)

^d UNIVERSITY OF CONNECTICUT SCHOOL OF MEDICINE   (United States)

^e YALE UNIVERSITY   (United States)

Author keywords

Alcoholism; Association; GABA; Genetics; Russian Population

Indexed keywords

4 AMINOBUTYRIC ACID RECEPTOR; RECEPTOR SUBTYPE;

ADULT; ALCOHOLISM; ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; GENE FREQUENCY; GENE LINKAGE DISEQUILIBRIUM; GENE LOCATION; GENOTYPE; HAPLOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; POPULATION RESEARCH; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; RUSSIAN FEDERATION; SINGLE NUCLEOTIDE POLYMORPHISM;

ADULT; ALCOHOLISM; ALLELES; DNA; GENE FREQUENCY; GENOTYPE; HAPLOTYPES; HUMANS; LINKAGE DISEQUILIBRIUM; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTORS, GABA-A; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RISK FACTORS; RUSSIA;

EID: 20244368365     PISSN: 01456008     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.ALC.0000158938.97464.90     Document Type: Article

References (26)

1. Barrett JC, Fry B, Maller J, Daly JM (2005) Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 21:263-265.
2. Bobak M, McKee M, Rose R, Marmot M (1999) Alcohol consumption in a national sample of the Russian population. Addiction 94:857-866.
3. Bobak M, Pikhart H, Hertzman C, Rose R, Marmot M (1998) Socioeconomic factors, perceived control and self-reported health in Russia. A cross-sectional survey. Soc Sci Med 47:269-279.
4. Bormann (2000) The "ABC" of GABA receptors. Trends Pharmacol Sci 21:16-19
5. Buck KJ (1996) Molecular genetic analysis of the role of GABAergic systems in the behavioral and cellular actions of alcohol. Behav Genet 26:313-323.
6. Covault J, Gelernter J, Hesselbrock V, Nellissery M, Kranzler HR (2004) Allelic and haplotypic association of GABRA2 with alcohol dependence. Am J Med Genet 129B:104-109.
7. Dick DM, Foroud T (2003) Candidate genes for alcohol dependence: a review of genetic evidence from human studies. Alcohol Clin Exp Res 27:868-879.
8. Duan J, Wainwright MS, Comeron JM, Saitou N, Sanders AR, Gelernter J, Gejman PV (2003) Synonymous mutations in the human dopamine receptor D2 (DRD2) affect mRNA stability and synthesis of the receptor. Hum Mol Genet 12:205-216.
9. Dudbridge F (2003) Pedigree disequilibrium tests for multilocus haplotypes. Genet Epidemiol 25:115-121.
10. Edenberg HJ, Dick DM, Xuei X, Tian H, Almasy L, Bauer LO, Crowe RR, Goate A, Hesselbrock V, Jones K, Kwon J, Li TK, Nurnberger JI Jr, O'Connor SJ, Reich T, Rice J, Schuckit MA, Porjesz B, Foroud T, Begleiter H (2004) Variations in GABRA2, encoding the alpha 2 subunit of the GABA(A) receptor, are associated with alcohol dependence and with brain oscillations. Am J Hum Genet 74:705-714.
11. Foroud T, Edenberg HJ, Goate A, Rice J, Flury L, Koller DL, Bierut LJ, Conneally PM, Nurnberger JI, Bucholz KK, Li TK, Hesselbrock V, Crowe R, Schuckit M, Porjesz B, Begleiter H, Reich T (2000) Alcoholism susceptibility loci: confirmation studies in a replicate sample and further mapping. Alcohol Clin Exp Res 24:933-945.
12. Heath AC, Bucholz KK, Madden PA, Dinwiddie SH, Slutske WS, Bierut LJ, Statham DJ, Dunne MP, Whitfield JB, Martin NG (1997) Genetic and environmental contributions to alcohol dependence risk in a national twin sample: consistency of findings in women and men. Psychol Med 27:1381-1396.
13. Kendler KS, Heath AC, Neale MC, Kessler RC, Eaves LJ (1992) A population-based twin study of alcoholism in women. JAMA 268:1877-1882.
14. Kendler KS, Prescott CA, Myers J, Neale MC (2003) The structure of genetic and environmental risk factors for common psychiatric and substance use disorders in men and women. Arch Gen Psychiatry 60:929-937.
15. Kendler KS, Prescott CA, Neale MC, Pedersen NL (1997) Temperance board registration for alcohol abuse in a national sample of Swedish male twins, born 1902 to 1949. Arch Gen Psychiatry 54:178-184.
16. Korpi ER, Grunder G, Luddens H (2002) Drug interactions at GABA(A) receptors. Prog Neurobiol 67:113-159.
17. Lappalainen J, Kranzler HR, Malison R, Price LH, Van Dyck C, Rosenheck RA, Cramer J, Southwick S, Charney D, Krystal J, Gelernter J (2002) A functional neuropeptide Y Leu7Pro polymorphism associated with alcohol dependence in a large population sample from the United States. Arch Gen Psychiatry 59:825-831.
18. Lautenberger JA, Stephens JC, O'Brien SJ, Smith MW (2000) Significant admixture linkage disequilibrium across 30 cM around the FY locus in African Americans. Am J Hum Genet 66:969-978.
19. Lewontin RC (1988) On measures of gametic disequilibrium. Genetics 120:849-852.
20. Long JC, Knowler WC, Hanson RL, Robin RW, Urbanek M, Moore E, Bennett PH, Goldman D (1998) Evidence for genetic linkage to alcohol dependence on chromosomes 4 and 11 from an autosome-wide scan in an American Indian population. Am J Med Genet 81:216-221.
21. Low K, Crestani F, Keist R, Benke D, Brunig I, Benson JA, Fritschy JM, Rulicke T, Bluethmann H, Mohler H, Rudolph U (2000) Molecular and neuronal substrate for the selective attenuation of anxiety. Science 290:131-134.
22. Nei M, Roychoudhury AK (1993) Evolutionary relationships of human populations on a global scale. Mol Biol Evol 10:927-943.
23. Nemtsov AV (2000) Estimates of total alcohol consumption in Russia, 1980-1994. Drug Alcohol Depend 58:133-142.
24. Reich T, Edenberg HJ, Goate A, Williams JT, Rice JP, Van Eerdewegh P, Foroud T, Hesselbrock V, Schuckit MA, Bucholz K, Porjesz B, Li TK, Conneally PM, Nurnberger JI Jr, Tischfield JA, Crowe RR, Cloninger CR, Wu W, Shears S, Carr K, Crose C, Willig C, Begleiter H (1998) Genome-wide search for genes affecting the risk for alcohol dependence. Am J Med Genet 81:207-215.
25. Stephens M, Donnelly P (2003) A comparison of bayesian methods for haplotype reconstruction from population genotype data. Am J Hum Genet 73:1162-1169.
26. Stephens M, Smith NJ, Donnelly P (2001) A new statistical method for haplotype reconstruction from population data. Am J Hum Genet 68:978-989.