Promoter polymorphism of the CD14 endotoxin receptor gene as a risk factor for alcoholic liver disease

Hepatology

Volumn 33, Issue 5, 2001, Pages 1148-1153

  Järveläinen, Harri A ^a   Orpana, Arto ^b   Perola, Markus ^c   Savolainen, Vesa T ^d   Karhunen, Pekka J ^d   Lindros, Kai O ^a  

^a NATIONAL PUBLIC HEALTH INSTITUTE   (Finland)

^b UNIVERSITY OF HELSINKI   (Finland)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d TAMPERE UNIVERSITY OF TECHNOLOGY   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

CD14 ANTIGEN; CYTOKINE; ENDOTOXIN; RECEPTOR;

ADULT; AGED; ALCOHOL LIVER CIRRHOSIS; ALCOHOL LIVER DISEASE; ARTICLE; AUTOPSY; CYTOKINE RELEASE; DNA POLYMORPHISM; FATTY LIVER; GENE FREQUENCY; GENETIC SUSCEPTIBILITY; GENOTYPE; HOMOZYGOSITY; HUMAN; HUMAN TISSUE; INFLAMMATION; KUPFFER CELL; LIVER FIBROSIS; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROMOTER REGION; RISK FACTOR; TWIN CONCORDANCE;

EID: 0035041058     PISSN: 02709139     EISSN: None     Source Type: Journal    
DOI: 10.1053/jhep.2001.24236     Document Type: Article

References (53)

1. Prospective evaluation of alcohol abuse and alcoholic liver injury in men as predictors of development of cirrhosis
2. Hepatic steatosis: Innocent bystander or guilty party?
3. Evidence of genetic predisposition to alcoholic cirrhosis and psychosis: Twin concordances for alcoholism and its biological end points by zygosity among male veterans
4. Genetic predisposition to organ-specific endpoints of alcoholism
5. Alcohol dehydrogenase polymorphisms and predisposition to alcoholic cirrhosis
6. Ethanol oxidizing enzymes: Roles in alcohol metabolism and alcoholic liver disease
7. Polymorphism in the cytochrome P450 2E1 gene and the risk of alcoholic liver disease
8. Endotoxemia in patients with alcoholic and non-alcoholic cirrhosis and in subjects with no evidence of chronic liver disease following acute alcohol excess
9. Severity of liver injury in experimental alcoholic liver disease. Correlation with plasma endotoxin, prostaglandin E2, leukotriene B4, and thromboxane B2
10. Alcohol and endotoxin: Another path to alcoholic liver injury?
11. Upregulation of mouse CD 14 expression in Kupffer cells by lipopolysaccharide
12. CD14 and other recognition molecules for lipopolysaccharide: A review
13. Lactobacillus feeding reduces endotoxemia and severity of experimental alcoholic liver disease
14. Antibiotics prevent liver injury in rats following long-term exposure to ethanol
15. Alcohol-induced expression of the CD14 endotoxin receptor protein in rat Kupffer cells
16. Alcohol causes both tolerance and sensitization of rat Kupffer cells via mechanisms dependent on endotoxin
17. A polymorphism* in the 5′ flanking region of the CD14 gene is associated with circulating soluble CD14 levels and with total serum immunoglobulin E
18. C(-260)T polymorphism in the promoter of the CD14 monocyte receptor gene as a risk factor for myocardial infarction
19. A new promoter polymorphism in the gene of lipopolysaccharide receptor CD14 is associated with expired myocardial infarction in patients with low atherosclerotic risk profile
20. Alcohol consumption and alcoholic liver disease: Evidence of a threshold level of effects of ethanol
21. Development of the alcohol use disorders identification test (AUDIT): WHO collaborative project on early detection of persons with harmful alcohol consumption-II
22. Validity of postmortem alcohol reports
23. Abuse of alcohol in sudden out-of-hospital deaths in Finland
24. Post-transfusion hepatitis C in Finland
25. Low prevalence of hepatitis C antibodies in chronic liver disease in Finland
26. Cytokines in alcoholic liver disease
27. Endotoxin and alcoholic liver disease: Tolerance and susceptibility
28. Cirrhosis in the alcoholic and its relation to the volume of alcohol abuse
29. Role of alcohol dehydrogenase polymorphism in ethanol metabolism and alcohol-related diseases
30. Genetic polymorphism of enzymes of alcohol metabolism and susceptibility to alcoholic liver disease
31. Polymorphism of alcohol dehydrogenase, alcohol and aldehyde dehydrogenase activities: Implication in alcoholic cirrhosis in white patients
32. Polymorphism of alcohol and aldehyde dehydrogenase genes and alcoholic cirrhosis in Chinese patients
33. Acetaldehyde inhibits NF-kappaB activation through IkappaBalpha preservation in rat Kupffer cells
34. CYP2E1 is not involved in early alcohol-induced liver injury
35. Alcoholic liver disease in heterozygotes of mutant and normal aldehyde dehydrogenase-2 genes
36. Genetic polymorphisms of cytochrome P4502E1 related to the development of alcoholic liver disease
37. Association between restriction fragment length polymorphism of the human cytochrome P450IIE1 gene and susceptibility to alcoholic liver cirrhosis
38. Association of a restriction fragment length polymorphism in the alcohol dehydrogenase 2 gene with Japanese alcoholic liver cirrhosis
39. Genetic factors in alcohol metabolism
40. Investigation of the role of polymorphisms at the alcohol and aldehyde dehydrogenase loci in genetic predisposition to alcohol-related end-organ damage
41. Association of restriction fragment length polymorphism in alcohol dehydrogenase 2 gene with alcohol induced liver damage
42. Association of a tumor necrosis factor promoter polymorphism with susceptibility to alcoholic steatohepatitis
43. Interleukin 10 promoter region polymorphisms and susceptibility to advanced alcoholic liver disease
44. Effect of chronic coadministration of endotoxin and ethanol on rat liver pathology and proinflammatory and anti-inflammatory cytokines
45. Anti-inflammatory cytokines
46. Antibodies to tumor necrosis factor alfa attenuate hepatic necrosis and inflammation caused by chronic exposure to ethanol in the rat
47. Essential role of tumor necrosis factor alpha in alcohol-induced liver injury in mice
48. Tumour necrosis factor (TNF) gene polymorphism influences TNF-alpha production in lipopolysaccharide (LPS)-stimulated whole blood cell culture in healthy humans
49. CD14 and lipopolysaccharide binding protein expression in a rat model of alcoholic liver disease
50. The Finnish population structure. A genetic and genealogical study
51. Disease gene mapping in isolated human populations: The example of Finland
52. Genetic dissection of complex traits