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Volumn 6, Issue 11, 2011, Pages

The PNPLA3 rs738409 148M/M genotype is a risk factor for liver cancer in alcoholic cirrhosis but shows no or weak association in hepatitis C cirrhosis

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGED; ALCOHOL LIVER CIRRHOSIS; ARTICLE; CANCER RISK; CAUCASIAN; CONTROLLED STUDY; FEMALE; GENE FREQUENCY; GENE FUNCTION; GENE IDENTIFICATION; GENE MUTATION; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETIC RISK; GENETIC SUSCEPTIBILITY; GENOTYPE; HEPATITIS C; HUMAN; LIVER CANCER; MAJOR CLINICAL STUDY; MALE; MARKER GENE; PNPLA3 GENE; RISK ASSESSMENT; CASE CONTROL STUDY; GENETIC PREDISPOSITION; GENETICS; LIVER CELL CARCINOMA; LIVER CIRRHOSIS; LIVER TUMOR; MIDDLE AGED; RISK FACTOR;

EID: 80455174482     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0027087     Document Type: Article
Times cited : (109)

References (28)
  • 1
    • 63049133092 scopus 로고    scopus 로고
    • Hepatocellular carcinoma incidence, mortality, and survival trends in the United States from 1975 to 2005
    • Altekruse SF, McGlynn KA, Reichman ME, (2009) Hepatocellular carcinoma incidence, mortality, and survival trends in the United States from 1975 to 2005. J Clin Oncol 27: 1485-1491.
    • (2009) J Clin Oncol , vol.27 , pp. 1485-1491
    • Altekruse, S.F.1    McGlynn, K.A.2    Reichman, M.E.3
  • 2
    • 67650938576 scopus 로고    scopus 로고
    • Hepatocellular carcinoma-epidemiological trends and risk factors
    • Schutte K, Bornschein J, Malfertheiner P, (2009) Hepatocellular carcinoma-epidemiological trends and risk factors. Dig Dis 27: 80-92.
    • (2009) Dig Dis , vol.27 , pp. 80-92
    • Schutte, K.1    Bornschein, J.2    Malfertheiner, P.3
  • 4
    • 7044229778 scopus 로고    scopus 로고
    • Primary liver cancer: worldwide incidence and trends
    • Bosch FX, Ribes J, Diaz M, Cleries R, (2004) Primary liver cancer: worldwide incidence and trends. Gastroenterology 127: S5-S16.
    • (2004) Gastroenterology , vol.127 , pp. 5-16
    • Bosch, F.X.1    Ribes, J.2    Diaz, M.3    Cleries, R.4
  • 5
    • 56749096610 scopus 로고    scopus 로고
    • Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease
    • Romeo S, Kozlitina J, Xing C, Pertsemlidis A, Cox D, et al. (2008) Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease. Nat Genet 40: 1461-1465.
    • (2008) Nat Genet , vol.40 , pp. 1461-1465
    • Romeo, S.1    Kozlitina, J.2    Xing, C.3    Pertsemlidis, A.4    Cox, D.5
  • 6
    • 78650054891 scopus 로고    scopus 로고
    • Specifically PNPLA3-mediated accumulation of liver fat in obese patients with type 2 diabetes
    • Petit JM, Guiu B, Masson D, Duvillard L, Jooste V, et al. (2010) Specifically PNPLA3-mediated accumulation of liver fat in obese patients with type 2 diabetes. J Clin Endocrinol Metab 95: E430-436.
    • (2010) J Clin Endocrinol Metab , vol.95 , pp. 430-436
    • Petit, J.M.1    Guiu, B.2    Masson, D.3    Duvillard, L.4    Jooste, V.5
  • 7
    • 78649448446 scopus 로고    scopus 로고
    • Regulation of the promoter region of the human adiponutrin/PNPLA3 gene by glucose and insulin
    • Rae-Whitcombe SM, Kennedy D, Voyles M, Thompson MP, (2010) Regulation of the promoter region of the human adiponutrin/PNPLA3 gene by glucose and insulin. Biochem Biophys Res Commun 402: 767-772.
    • (2010) Biochem Biophys Res Commun , vol.402 , pp. 767-772
    • Rae-Whitcombe, S.M.1    Kennedy, D.2    Voyles, M.3    Thompson, M.P.4
  • 8
    • 77956630787 scopus 로고    scopus 로고
    • PNPLA3 variants specifically confer increased risk for histologic nonalcoholic fatty liver disease but not metabolic disease
    • Speliotes EK, Butler JL, Palmer CD, Voight BF, Hirschhorn JN, (2010) PNPLA3 variants specifically confer increased risk for histologic nonalcoholic fatty liver disease but not metabolic disease. Hepatology 52: 904-912.
    • (2010) Hepatology , vol.52 , pp. 904-912
    • Speliotes, E.K.1    Butler, J.L.2    Palmer, C.D.3    Voight, B.F.4    Hirschhorn, J.N.5
  • 9
    • 77957936457 scopus 로고    scopus 로고
    • I148M patatin-like phospholipase domain-containing 3 gene variant and severity of pediatric nonalcoholic fatty liver disease
    • Valenti L, Alisi A, Galmozzi E, Bartuli A, Del Menico B, et al. (2010) I148M patatin-like phospholipase domain-containing 3 gene variant and severity of pediatric nonalcoholic fatty liver disease. Hepatology 52: 1274-1280.
    • (2010) Hepatology , vol.52 , pp. 1274-1280
    • Valenti, L.1    Alisi, A.2    Galmozzi, E.3    Bartuli, A.4    Del Menico, B.5
  • 10
    • 77957970113 scopus 로고    scopus 로고
    • A common variant in the patatin-like phospholipase 3 gene (PNPLA3) is associated with fatty liver disease in obese children and adolescents
    • Santoro N, Kursawe R, D'Adamo E, Dykas DJ, Zhang CK, et al. (2010) A common variant in the patatin-like phospholipase 3 gene (PNPLA3) is associated with fatty liver disease in obese children and adolescents. Hepatology 52: 1281-1290.
    • (2010) Hepatology , vol.52 , pp. 1281-1290
    • Santoro, N.1    Kursawe, R.2    D'Adamo, E.3    Dykas, D.J.4    Zhang, C.K.5
  • 11
    • 78650064129 scopus 로고    scopus 로고
    • Effects of PNPLA3 on liver fat and metabolic profile in Hispanic children and adolescents
    • Goran MI, Walker R, Le KA, Mahurkar S, Vikman S, et al. (2010) Effects of PNPLA3 on liver fat and metabolic profile in Hispanic children and adolescents. Diabetes 59: 3127-3130.
    • (2010) Diabetes , vol.59 , pp. 3127-3130
    • Goran, M.I.1    Walker, R.2    Le, K.A.3    Mahurkar, S.4    Vikman, S.5
  • 12
    • 70449403261 scopus 로고    scopus 로고
    • Genetic evidence for a role of adiponutrin in the metabolism of apolipoprotein B-containing lipoproteins
    • Kollerits B, Coassin S, Beckmann ND, Teumer A, Kiechl S, et al. (2009) Genetic evidence for a role of adiponutrin in the metabolism of apolipoprotein B-containing lipoproteins. Hum Mol Genet 18: 4669-4676.
    • (2009) Hum Mol Genet , vol.18 , pp. 4669-4676
    • Kollerits, B.1    Coassin, S.2    Beckmann, N.D.3    Teumer, A.4    Kiechl, S.5
  • 13
    • 74249093842 scopus 로고    scopus 로고
    • Morbid obesity exposes the association between PNPLA3 I148M (rs738409) and indices of hepatic injury in individuals of European descent
    • Romeo S, Sentinelli F, Dash S, Yeo GS, Savage DB, et al. (2010) Morbid obesity exposes the association between PNPLA3 I148M (rs738409) and indices of hepatic injury in individuals of European descent. Int J Obes (Lond) 34: 190-194.
    • (2010) Int J Obes (Lond) , vol.34 , pp. 190-194
    • Romeo, S.1    Sentinelli, F.2    Dash, S.3    Yeo, G.S.4    Savage, D.B.5
  • 14
    • 69249111667 scopus 로고    scopus 로고
    • A nonsynonymous gene variant in the adiponutrin gene is associated with nonalcoholic fatty liver disease severity
    • Sookoian S, Castano GO, Burgueno AL, Gianotti TF, Rosselli MS, et al. (2009) A nonsynonymous gene variant in the adiponutrin gene is associated with nonalcoholic fatty liver disease severity. J Lipid Res 50: 2111-2116.
    • (2009) J Lipid Res , vol.50 , pp. 2111-2116
    • Sookoian, S.1    Castano, G.O.2    Burgueno, A.L.3    Gianotti, T.F.4    Rosselli, M.S.5
  • 16
    • 79959562237 scopus 로고    scopus 로고
    • Variant adiponutrin (PNPLA3) represents a common fibrosis risk gene: Non-invasive elastography-based study in chronic liver disease
    • Krawczyk M, Grunhage F, Zimmer V, Lammert F, (2011) Variant adiponutrin (PNPLA3) represents a common fibrosis risk gene: Non-invasive elastography-based study in chronic liver disease. J Hepatol 55: 299-306.
    • (2011) J Hepatol , vol.55 , pp. 299-306
    • Krawczyk, M.1    Grunhage, F.2    Zimmer, V.3    Lammert, F.4
  • 17
    • 78751536418 scopus 로고    scopus 로고
    • Genetic variation in the PNPLA3 gene is associated with alcoholic liver injury in caucasians
    • Stickel F, Buch S, Lau K, zu Schwabedissen HM, Berg T, et al. (2011) Genetic variation in the PNPLA3 gene is associated with alcoholic liver injury in caucasians. Hepatology 53: 86-95.
    • (2011) Hepatology , vol.53 , pp. 86-95
    • Stickel, F.1    Buch, S.2    Lau, K.3    zu Schwabedissen, H.M.4    Berg, T.5
  • 18
    • 79959561798 scopus 로고    scopus 로고
    • Common polymorphism in the PNPLA3/adiponutrin gene confers higher risk of cirrhosis and liver damage in alcoholic liver disease
    • 2011 Feb 18. [Epub ahead of print]
    • Trepo E, Gustot T, Degre D, Lemmers A, Verset L, et al. (2011) Common polymorphism in the PNPLA3/adiponutrin gene confers higher risk of cirrhosis and liver damage in alcoholic liver disease. J Hepatol 2011 Feb 18. [Epub ahead of print].
    • (2011) J Hepatol
    • Trepo, E.1    Gustot, T.2    Degre, D.3    Lemmers, A.4    Verset, L.5
  • 19
    • 79955085671 scopus 로고    scopus 로고
    • Patatin-like phospholipase domain containing 3 sequence variant and hepatocellular carcinoma
    • author reply 1777
    • Corradini SG, Burza MA, Molinaro A, Romeo S, (2011) Patatin-like phospholipase domain containing 3 sequence variant and hepatocellular carcinoma. Hepatology 53: 1776; author reply 1777.
    • (2011) Hepatology , vol.53 , pp. 1776
    • Corradini, S.G.1    Burza, M.A.2    Molinaro, A.3    Romeo, S.4
  • 20
    • 79952222716 scopus 로고    scopus 로고
    • Patatin-Like phospholipase domain-containing 3 I148M polymorphism, steatosis, and liver damage in chronic hepatitis C
    • Valenti L, Rumi M, Galmozzi E, Aghemo A, Menico BD, et al. (2011) Patatin-Like phospholipase domain-containing 3 I148M polymorphism, steatosis, and liver damage in chronic hepatitis C. Hepatology 53: 791-9.
    • (2011) Hepatology , vol.53 , pp. 791-799
    • Valenti, L.1    Rumi, M.2    Galmozzi, E.3    Aghemo, A.4    Menico, B.D.5
  • 21
    • 79961186012 scopus 로고    scopus 로고
    • PNPLA3 rs738409C/G polymorphism in cirrhosis: relationship with the aetiology of liver disease and hepatocellular carcinoma occurrence
    • 2011 Apr 19. [Epub ahead of print]
    • Falleti E, Fabris C, Cmet S, Cussigh A, Bitetto D, et al. (2011) PNPLA3 rs738409C/G polymorphism in cirrhosis: relationship with the aetiology of liver disease and hepatocellular carcinoma occurrence. Liver Int 2011 Apr 19. [Epub ahead of print].
    • (2011) Liver Int
    • Falleti, E.1    Fabris, C.2    Cmet, S.3    Cussigh, A.4    Bitetto, D.5
  • 22
    • 27644499523 scopus 로고    scopus 로고
    • Review article: non-alcoholic fatty liver disease and hepatitis C-risk factors and clinical implications
    • Sanyal AJ, (2005) Review article: non-alcoholic fatty liver disease and hepatitis C-risk factors and clinical implications. Aliment Pharmacol Ther 22 (Suppl 2): 48-51.
    • (2005) Aliment Pharmacol Ther , vol.22 , Issue.SUPPL. 2 , pp. 48-51
    • Sanyal, A.J.1
  • 23
    • 10344262633 scopus 로고    scopus 로고
    • Identification, cloning, expression, and purification of three novel human calcium-independent phospholipase A2 family members possessing triacylglycerol lipase and acylglycerol transacylase activities
    • Jenkins CM, Mancuso DJ, Yan W, Sims HF, Gibson B, et al. (2004) Identification, cloning, expression, and purification of three novel human calcium-independent phospholipase A2 family members possessing triacylglycerol lipase and acylglycerol transacylase activities. J Biol Chem 279: 48968-48975.
    • (2004) J Biol Chem , vol.279 , pp. 48968-48975
    • Jenkins, C.M.1    Mancuso, D.J.2    Yan, W.3    Sims, H.F.4    Gibson, B.5
  • 24
    • 77949895032 scopus 로고    scopus 로고
    • A sequence variation (I148M) in PNPLA3 associated with nonalcoholic fatty liver disease disrupts triglyceride hydrolysis
    • He S, McPhaul C, Li JZ, Garuti R, Kinch L, et al. (2010) A sequence variation (I148M) in PNPLA3 associated with nonalcoholic fatty liver disease disrupts triglyceride hydrolysis. J Biol Chem 285: 6706-6715.
    • (2010) J Biol Chem , vol.285 , pp. 6706-6715
    • He, S.1    McPhaul, C.2    Li, J.Z.3    Garuti, R.4    Kinch, L.5
  • 25
    • 77956625538 scopus 로고    scopus 로고
    • Chan L Patatin-like phospholipase domain-containing 3/adiponutrin deficiency in mice is not associated with fatty liver disease
    • Chen W, Chang B, Li L, (2010) Chan L Patatin-like phospholipase domain-containing 3/adiponutrin deficiency in mice is not associated with fatty liver disease. Hepatology 52: 1134-1142.
    • (2010) Hepatology , vol.52 , pp. 1134-1142
    • Chen, W.1    Chang, B.2    Li, L.3
  • 26
    • 77957941549 scopus 로고    scopus 로고
    • Patatin-like phospholipase domain-containing 3 and the pathogenesis and progression of pediatric nonalcoholic fatty liver disease
    • Browning JD, Cohen JC, Hobbs HH, (2010) Patatin-like phospholipase domain-containing 3 and the pathogenesis and progression of pediatric nonalcoholic fatty liver disease. Hepatology 52: 1189-1192.
    • (2010) Hepatology , vol.52 , pp. 1189-1192
    • Browning, J.D.1    Cohen, J.C.2    Hobbs, H.H.3
  • 27
    • 77956636268 scopus 로고    scopus 로고
    • The association of genetic variability in patatin-like phospholipase domain-containing protein 3 (PNPLA3) with histological severity of nonalcoholic fatty liver disease
    • Rotman Y, Koh C, Zmuda JM, Kleiner DE, Liang TJ, (2010) The association of genetic variability in patatin-like phospholipase domain-containing protein 3 (PNPLA3) with histological severity of nonalcoholic fatty liver disease. Hepatology 52: 894-903.
    • (2010) Hepatology , vol.52 , pp. 894-903
    • Rotman, Y.1    Koh, C.2    Zmuda, J.M.3    Kleiner, D.E.4    Liang, T.J.5
  • 28
    • 77950607738 scopus 로고    scopus 로고
    • Homozygosity for the patatin-like phospholipase-3/adiponutrin I148M polymorphism influences liver fibrosis in patients with nonalcoholic fatty liver disease
    • Valenti L, Al-Serri A, Daly AK, Galmozzi E, Rametta R, et al. (2010) Homozygosity for the patatin-like phospholipase-3/adiponutrin I148M polymorphism influences liver fibrosis in patients with nonalcoholic fatty liver disease. Hepatology 51: 1209-1217.
    • (2010) Hepatology , vol.51 , pp. 1209-1217
    • Valenti, L.1    Al-Serri, A.2    Daly, A.K.3    Galmozzi, E.4    Rametta, R.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.