Interleukin 10 promoter region polymorphisms and susceptibility to advanced alcoholic liver disease

Gut

Volumn 46, Issue 4, 2000, Pages 540-545

  Grove, J ^a   Daly, A K ^a   Bassendine, M F ^a   Gilvarry, E ^a   Day, C P ^a  

^a NEWCASTLE UNIVERSITY   (United Kingdom)

Author keywords

Cirrhosis; Ethyl alcohol; Generic polymorphism; Interleukin 10

Indexed keywords

INTERLEUKIN 10;

ALCOHOL LIVER DISEASE; ALCOHOLISM; AMINO ACID SUBSTITUTION; ARTICLE; CONTROLLED STUDY; CYTOKINE RELEASE; DNA POLYMORPHISM; FEMALE; GENE EXPRESSION; GENE FREQUENCY; GENE LINKAGE DISEQUILIBRIUM; GENETIC ASSOCIATION; GENETIC RISK; GENETIC SUSCEPTIBILITY; HUMAN; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROMOTER REGION;

ALLELES; CASE-CONTROL STUDIES; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HUMANS; INTERLEUKIN-10; LIVER CIRRHOSIS, ALCOHOLIC; MALE; ODDS RATIO; POLYMORPHISM, GENETIC; PROMOTER REGIONS (GENETICS);

EID: 0034109157     PISSN: 00175749     EISSN: None     Source Type: Journal    
DOI: 10.1136/gut.46.4.540     Document Type: Article

References (52)

1. 1 Bellantani S, Costa G, Saccoccio G, et al. Drinking habits as cofactors of risk for alcohol-induced liver damage. Gut 1997;41:845-50.
2. 2 Becker U, Deis A, Sorensen TIA, et al. Prediction of risk of liver disease by alcohol intake, sex and age: a prospective population study. Hepatology 1996;23:1025-9.
3. 3 Hrubec Z, Omenn GS. Evidence of a genetic predisposition to alcoholic cirrhosis and psychosis; twin concordances for alcoholism and its biological end points by zygosity among male veterans. Alcohol Clin Exp Res 1984;9:306-9.
4. 4 Reed T, Page WF, Viken RJ, et al. Genetic predisposition to organ specific endpoints of alcoholism. Alcohol Clin Exp Res 1996;20:1528-33.
5. 5 Whitfield JB. Meta-analysis of the effects of alcohol dehydrogenase genotype on alcohol dependence and alcoholic liver disease. Alcohol Alcohol 1997;32:613-19.
6. 6 Bassendine MF, Day CP. The inheritance of alcoholic liver disease. Baillieres Clin Gastroenterol 1998;12:317-35.
7. 7 Day CP, James OFW, Bassendine MF, et al. Alcohol dehydrogenase polymorphisms and predisposition to alcoholic cirrhosis. Hepatology 1993;18:230-1.
8. 8 Grove J, Daly AK, Brown AStJM, et al. The Rsa I polymorphism of CYP2E1 and susceptibility to alcoholic liver disease in Caucasians: effect on age of presentation and dependence on alcohol dehydrogenase genotype. Pharmacogenetics 1998;8:335-42.
9. 9 Carr LG, Hartleroad JY, Liang YB, et al. Polymorphism at the P450IIE1 locus is not associated with alcoholic liver disease in Caucasian men. Alcohol Clin Exp Res 1995;19: 182-4.
10. 10 Jarvelainen HA, Fang C, Indelman-Sundberg M, et al. Effect of chronic coadministration of endotoxin and ethanol on rat liver pathology and proinflammatory and anti-inflammatory cytokines. Hepatology 1999;29:1503-10.
11. 11 Grove J, Daly AK, Bassendine MF, et al. Association of a tumor necrosis factor polymorphism with susceptibility to alcoholic steatohepatitis. Hepatology 1997;26:143-6.
12. 12 Ramsay LA, Smith S, Taylor C, et al. Susceptibility to alcoholic liver disease (ALD) and tumour necrosis factor (TNF-alpha) promoter polymorphisms [abstract]. J Hepatol 1996;25(Suppl.1):110.
13. 13 Allott RL, Quest LJ, Pirmohammed M, et al. Investigation of the role of the TNFα gene polymorphism in alcoholic liver disease (ALD) [abstract]. Hepatology 1996;24:443A.
14. 14 Moore KW, O'Garra AO, de Waal Malefyt R, et al. Interleukin-10. Ann Rev Immunol 1993;11:165-90.
15. 15 Thompson K, Maltby J, Fallowfield J, et al. Interleukin-10 expression and function in experimental murine liver inflammation and fibrosis. Hepatology 1998;28:1597-600.
16. 16 Alfrey EJ, Most D, Wang X, et al. Interferon-gamma and interleukin-10 messenger RNA are up-regulated after orthotopic liver transplantation in tolerant rats: evidence for cytokine-mediated immune dysregulation. Surgery 1995;118:399-405.
17. 17 Thompson K, Trowern A, Fowell A, et al. Primary rat and mouse hepatic stellate cells express the macrophage inhibitor cytokine interleukin-10 during the course of activation in vitro. Hepatology 1998;28:1518-24.
18. 18 Del Prete GM, DeCarli F, Almerigogna MG, et al. Human IL-10 is produced by both type 1 helper (Th1) and type 2 helper (Th2) T cell clones and inhibits their antigen-specific proliferation and cytokine production, J Immunol 1993;150:353-60.
19. 19 de Waal Malefyt RJ, Haanen H, Spits MG, et al. Interleukin 10 (IL-10) and viral IL-10 strongly reduce antigen-specific human T cell proliferation by diminishing the antigen presenting capacity of monocytes via down regulation of class II major histocompatibility complex expression. J Exp Med 1991;174:915-24.
20. 20 Willems F, Marchant A, Delville JP, et al. Interleukin-10 inhibits B7 and intercellular adhesion molecule-1 expression on human monocytes. Eur J Immunol 1994;24:1007-9.
21. 21 Rousset FE, Garcia T, Defrance C, et al. Interleukin 10 is a potent growth and differentiation factor for activated human B lymphocytes. Proc Natl Acad Sci USA 1992;89: 1890-3.
22. 22 Defrance T, Vanbervliet B, Briere F, et al. Interleukin 10 and transforming growth factor beta cooperate to induce anti-CD40-activated naive human B cells to secrete immunoglobulin A. J Exp Med 1992;175:671-82.
23. 23 de Waal Malefyt RJ, Abrams J, Bennett B, et al. Interleukin 10 (IL-10) inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by monocytes. J Exp Med 1991;174:1209-20.
24. 24 Fiorentino DF, Zlotnik A, Mosmann TR, et al. IL-10 inhibits cytokine production by activated macrophages. J Immunol 1991;147:3815-22.
25. 25 Kasama T, Strieter RM, Lukacs MW, et al. Regulation of neutrophil derived chemokine expression by IL-10. J Immunol 1994;152:3559-69.
26. 26 Wang SC, Ohata M, Scrum L, et al. Expression of interleukin-10 by in vitro and in vivo activated hepatic stellate cells. J Biol Chem 1998;273:302-8.
27. 27 Arai T, Hiromatsu K, Kobayashi N, et al. IL-10 is involved in the protective effect of dibutyryl cyclic adenosine monophosphate on endotoxin-induced inflammatory liver injury. J Immunol 1995;155:5743-9.
28. 28 Gazzinelli RT, Wysocka M, Hieny S, et al. In the absence of endogenous IL-10, mice acutely infected with Toxoplasma gondii succumb to a lethal immune response dependent on CD4+ T cells and accompanied by overproduction of 1L-12, IFN-γ and TNF-α. J Immunol 1996;157:798-805.
29. 29 Louis H, Le Moine O, Peny MO, et al. Production and role of interleukin-10 in concanavalin A-induced hepatitis in mice. Hepatology 1997;25:1382-9.
30. 30 Louis H, Le Moine O, Peny MO, et al. Hepatoprotective role of interleukin 10 in galactosamine/lipopolysaccharide mouse liver injury. Gastroenterology 1997;112:935-42.
31. 31 Louis H, Van Laethem JL, Wu W, et al. Interleukin-10 controls neutrophilic infiltration, hepatocyte proliferation, and liver fibrosis induced by carbon tetrachloride in mice. Hepatology 1998;28:1607-15.
32. 32 Israel Y. Antibodies against ethanol-derived protein adducts: pathogenic implications. Gastroenterology 1997; 113:353-5.
33. 33 Westendorp RG, Langermans JA, Huizinga TW, et al. Genetic influence on cytokine production and fatal meningococcal disease. Lancet 1997;349:170-3.
34. 34 Turner DM, Williams DM, Sankaran D, et al. An investigation of polymorphism in the interleukin-10 gene promoter. Eur J Immunogenet 1997;24:1-8.
35. 35 Eskdale J, Kube D, Tesch H, et al. Mapping of the IL-10 gene and further characterization of the 5′ flanking sequence. Immunogenetics 1997;46:120-8.
36. 36 Lim S, Crawley E, Woo P, et al. Haplotype associated with low interleukin-10 production in patients with severe asthma. Lancet 1998;352:113.
37. 37 Hobbs K, Negri J, Klinnert M, et al. Interleukin-10 and transforming growth factor-β promoter polymorphisms in allergies and asthma. Am J Respir Crit Care Med 1998;158: 1958-62.
38. 38 Borish L, Aarons A, Rumbyrt J, et al. Interleukin-10 regulation in normal subjects and patients with asthma. J Allergy Clin Immunol 1996;97:1288-96.
39. 39 Lazarus M, Hajeer AH, Turner D, et al. Genetic variation in the interleukin 10 gene promoter and systemic lupus erythematosus. J Rheumatol 1997;24:2314-17.
40. 40 Edwards-Smith CJ, Jonsson JR, Purdie DM, et al. Interleukin-10 promoter polymorphism predicts initial response of chronic hepatitis C to interferon alfa. Hepatology 1999;30:526-30.
41. 41 Rosenwasser LJ, Borish L. Genetics of atopy and asthma: the rationale behind promoter-based candidate gene studies (IL-4 and IL-10).Am J Respir Crit Care Med 1997;156: S152-5.
42. 42 Crawley E, Kay R, Sillibourne J, et al. Polymorphic haplotypes of the interleukin-10 5′ flanking region determine variable interleukin-10 transcription and are associated with particular phenotypes of juvenile rheumatoid arthritis. Arthritis Rheum 1999;42:1101-8.
43. 43 Wu A, Slavin G, Levi AJ. Elevated serum gamma-glutamyl-transferase (transpeptidase) and histological damage in alcoholics. Am J Gastroenterol 1976;65:318-23.
44. 44 Grove J, Daly AK, Burt AD, et al. Heterozygotes for HFE mutations have no increased risk of advanced alcoholic liver disease. Gut 1998;43:262-6.
45. 45 Bruguera M, Bordas JM, Rodes J. Asymptomatic liver disease in alcoholics. Arch Pathol Lab Med 1977;101:644-7.
46. 46 Speilman RS, McGinnis RE, Ewens WJ. Transmission test for linkage disequilibrium: the insulin gene region and insulin-dependent diabetes mellitus. Am J Hum Genet 1993;52:506-16.
47. 47 Bashir R, Day CP, James OFW, et al. No evidence for involvement of type I collagen structural genes in "genetic predisposition" 10 alcoholic cirrhosis. J Hepatol 1992;16: 316-19.
48. 48 Gilligan SB, Cloninger CR. The genetics of alcoholism. In: Crow K, Batt RD, eds. Human metabolism of alcohol. Boca Raton, Florida: CRC Press, 1987.
49. 49 Clot P, Parola M, Bellomo G, et al. Plasma membrane hydroxyethyl radical adducts cause antibody-dependent cytotoxicity in rat hepatocytes exposed to alcohol. Gastroenterology 1997;113:265-76.
50. 50 Eskdale J, Gallagher G, Verweij CL, et al. Interleukin 10 secretion in relation to human IL-10 locus haplotypes. Proc Natl Acad Sci USA 1998;95:9465-70.
51. 51 Eskdale J, McNicholl J, Wordsworth P, et al. Interleukin-10 microsatellite polymorphisms and IL-10 locus alleles in rheumatoid arthritis susceptibility. Lancet 1998;352:1282-3.
52. 52 Bogdan C, Vodovotz Y, Nathan C. Macrophage deactivation by interleukin 10. J Exp Med 1991;174:1549-55.