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Volumn 10, Issue , 2015, Pages 1909-1924

Cell-based therapies of liver diseases: Age-related challenges

Author keywords

Cell aging; Liver cell therapy; Liver engineering; Rejuvenation

Indexed keywords

AGE; AGING; CELL DIFFERENTIATION; CELL EXPANSION; CELL THERAPY; CELL TRANSDIFFERENTIATION; CELL TRANSPLANTATION; DNA METHYLATION; HOLISTIC CARE; HUMAN; LIVER BIOPSY; LIVER CELL; LIVER DISEASE; MESENCHYMAL STEM CELL; PLURIPOTENT STEM CELL; REGENERATIVE MEDICINE; REVIEW; SKIN FIBROBLAST; TISSUE ENGINEERING; BIOLOGICAL THERAPY; CELL REPROGRAMMING TECHNIQUE; FIBROBLAST; INDUCED PLURIPOTENT STEM CELL; LIVER DISEASES; LIVER REGENERATION; MESENCHYMAL STROMA CELL; METABOLISM; PHYSIOLOGY; PROCEDURES; TELOMERE HOMEOSTASIS;

EID: 84949812891     PISSN: 11769092     EISSN: 11781998     Source Type: Journal    
DOI: 10.2147/CIA.S97926     Document Type: Review
Times cited : (15)

References (164)
  • 2
    • 0037220482 scopus 로고    scopus 로고
    • Liver fibrosis – from bench to bedside
    • Friedman SL. Liver fibrosis – from bench to bedside. J Hepatol. 2003;38(Suppl 1):S38–S53.
    • (2003) J Hepatol , vol.38 , pp. S38-S53
    • Friedman, S.L.1
  • 3
    • 84871036375 scopus 로고    scopus 로고
    • Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: A systematic analysis for the Global Burden of Disease Study 2010
    • Lozano R, Naghavi M, Foreman K, et al. Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet. 2012;380(9859):2095–2128.
    • (2012) Lancet , vol.380 , Issue.9859 , pp. 2095-2128
    • Lozano, R.1    Naghavi, M.2    Foreman, K.3
  • 4
    • 58849143425 scopus 로고    scopus 로고
    • The epidemiology of hepatocellular cancer: From the perspectives of public health problem to tumor biology
    • Caldwell S, Park SH. The epidemiology of hepatocellular cancer: from the perspectives of public health problem to tumor biology. J Gastroenterol. 2009;44(Suppl 19):96–101.
    • (2009) J Gastroenterol , vol.44 , pp. 96-101
    • Caldwell, S.1    Park, S.H.2
  • 5
    • 28844490547 scopus 로고    scopus 로고
    • Natural history and prognostic indicators of review of 118 studies
    • D’Amico G, Garcia-Tsao G, Pagliaro L. Natural history and prognostic indicators of survival in cirrhosis: a systematic review of 118 studies. J Hepatol. 2006;44(1):217–231.
    • (2006) J Hepatol , vol.44 , Issue.1 , pp. 217-231
    • D’Amico, G.1    Garcia-Tsao, G.2    Pagliaro, L.3
  • 6
    • 84872001081 scopus 로고    scopus 로고
    • Long-term management of the successful adult liver transplant: 2012 practice guideline by the American Association for the Study of Liver Diseases and the American Society of Transplantation
    • Lucey MR, Terrault N, Ojo L, et al. Long-term management of the successful adult liver transplant: 2012 practice guideline by the American Association for the Study of Liver Diseases and the American Society of Transplantation. Liver Transpl. 2013;19(1):3–26.
    • (2013) Liver Transpl , vol.19 , Issue.1 , pp. 3-26
    • Lucey, M.R.1    Terrault, N.2    Ojo, L.3
  • 7
    • 84977985902 scopus 로고    scopus 로고
    • Adult stem cell and mesenchymal progenitor theories of aging
    • Fukada S, Ma Y, Uezumi A. Adult stem cell and mesenchymal progenitor theories of aging. Front Cell Dev Biol. 2014;2:10.v in the era of induced pluripotency. Cell Stem Cell. 2015;16(6):591–600.
    • (2014) Front Cell Dev Biol , vol.2 , Issue.6 , pp. 591-600
    • Fukada, S.1    Ma, Y.2    Uezumi, A.3
  • 8
    • 84943796922 scopus 로고    scopus 로고
    • Epigenetic control of stem cell potential during homeostasis, aging, and disease
    • Beerman I, Rossi DJ. Epigenetic control of stem cell potential during homeostasis, aging, and disease. Cell Stem Cell. 2015;16(6): 613-625.
    • (2015) Cell Stem Cell , vol.16 , Issue.6 , pp. 613-625
    • Beerman, I.1    Rossi, D.J.2
  • 9
    • 84973101467 scopus 로고    scopus 로고
    • Aging of stem and progenitor cells: mechanisms, impact on the therapeutic potential and rejuvenation
    • Nurkovic JS, Volarevic V, Lako M, et al. Aging of stem and progenitor cells: mechanisms, impact on the therapeutic potential and rejuvenation. Rejuvenation Res. Epub 2015 Jun 9
    • (2015) Rejuvenation Res. Epub
    • Nurkovic, J.S.1    Volarevic, V.2    Lako, M.3
  • 10
    • 84942124058 scopus 로고    scopus 로고
    • Programming and reprogramming cellular age in the era of induced pluripotency
    • Studer L, Vera E, Cornacchia D. Programming and reprogramming cellular age in the era of induced pluripotency. Cell Stem Cell. 2015; 16(6):591-600.
    • (2015) Cell Stem Cell , vol.16 , Issue.6 , pp. 591-600
    • Studer, L.1    Vera, V.2    Cornacchia, D.3
  • 11
    • 80455144472 scopus 로고    scopus 로고
    • Rejuvenating senescent and centenarian human cells by reprogramming through the pluripotent state
    • Lapasset L, Milhavet O, Prieur A, et al. Rejuvenating senescent and centenarian human cells by reprogramming through the pluripotent state. Genes Dev. 2011;25(21):2248–2253.
    • (2011) Genes Dev , vol.25 , Issue.21 , pp. 2248-2253
    • Lapasset, L.1    Milhavet, O.2    Prieur, A.3
  • 12
    • 84890109489 scopus 로고    scopus 로고
    • Human iPSC-based modeling of late-onset disease via progerin-induced aging
    • Miller JD, Ganat YM, Kishinevsky S, et al. Human iPSC-based modeling of late-onset disease via progerin-induced aging. Cell Stem Cell. 2013;13(6):691–705.
    • (2013) Cell Stem Cell , vol.13 , Issue.6 , pp. 691-705
    • Miller, J.D.1    Ganat, Y.M.2    Kishinevsky, S.3
  • 13
    • 36248966518 scopus 로고    scopus 로고
    • Induction of pluripotent stem cells from adult human fibroblasts by defined factors
    • Takahashi K, Tanabe K, Ohnuki M, et al. Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell. 2007;131(5):861–872.
    • (2007) Cell , vol.131 , Issue.5 , pp. 861-872
    • Takahashi, K.1    Tanabe, K.2    Ohnuki, M.3
  • 14
    • 33747195353 scopus 로고    scopus 로고
    • Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors
    • Takahashi K, Yamanaka S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell. 2006;126(4):663–676.
    • (2006) Cell , vol.126 , Issue.4 , pp. 663-676
    • Takahashi, K.1    Yamanaka, S.2
  • 15
    • 69349103956 scopus 로고    scopus 로고
    • The Ink4/Arf locus is a barrier for iPS cell reprogramming
    • Li H, Collado M, Villasante A, et al. The Ink4/Arf locus is a barrier for iPS cell reprogramming. Nature. 2009;460(7259):1136–1139.
    • (2009) Nature , vol.460 , Issue.7259 , pp. 1136-1139
    • Li, H.1    Collado, M.2    Villasante, A.3
  • 16
    • 84865774967 scopus 로고    scopus 로고
    • Reprogramming efficiency and quality of induced pluripotent stem cells (IPSCs) generated from muscle-derived fibroblasts of mdx mice at different ages
    • RRN1274
    • Wang B, Miyagoe-Suzuki Y, Yada E, et al. Reprogramming efficiency and quality of induced pluripotent stem cells (iPSCs) generated from muscle-derived fibroblasts of mdx mice at different ages. PLoS Curr. 2011;3:RRN1274.
    • (2011) Plos Curr. , vol.3
    • Wang, B.1    Miyagoe-Suzuki, Y.2    Yada, E.3
  • 17
    • 79953850339 scopus 로고    scopus 로고
    • Establishment of induced pluripotent stem cells from aged mice using bone marrow-derived myeloid cells
    • Cheng Z, Ito S, Nishio N, et al. Establishment of induced pluripotent stem cells from aged mice using bone marrow-derived myeloid cells. J Mol Cell Biol. 2011;3(2):91–98.
    • (2011) J Mol Cell Biol , vol.3 , Issue.2 , pp. 91-98
    • Cheng, Z.1    Ito, S.2    Nishio, N.3
  • 18
    • 84864330048 scopus 로고    scopus 로고
    • Establishment of induced pluripotent stem cells from centenarians for neurodegenerative disease research
    • Yagi T, Kosakai A, Ito D, et al. Establishment of induced pluripotent stem cells from centenarians for neurodegenerative disease research. PLoS One. 2012;7:e41572.
    • (2012) Plos One , vol.7
    • Yagi, T.1    Kosakai, A.2    Ito, D.3
  • 19
    • 77958082207 scopus 로고    scopus 로고
    • Generation of transgene-free lung disease-specific human induced pluripotent stem cells using a single excisable lentiviral stem cell cassette
    • Somers A, Jean JC, Sommer CA, et al. Generation of transgene-free lung disease-specific human induced pluripotent stem cells using a single excisable lentiviral stem cell cassette. Stem Cells. 2010;28(10):1728–1740.
    • (2010) Stem Cells , vol.28 , Issue.10 , pp. 1728-1740
    • Somers, A.1    Jean, J.C.2    Sommer, C.A.3
  • 20
    • 84880068090 scopus 로고    scopus 로고
    • The role of SIRT6 protein in aging and reprogramming of human induced pluripotent stem cells
    • Sharma A, Diecke S, Zhang WY, et al. The role of SIRT6 protein in aging and reprogramming of human induced pluripotent stem cells. J Biol Chem. 2013;288(25):18439–18447.
    • (2013) J Biol Chem , vol.288 , Issue.25 , pp. 18439-18447
    • Sharma, A.1    Diecke, S.2    Zhang, W.Y.3
  • 21
    • 84942093575 scopus 로고    scopus 로고
    • Methods of induced pluripotent stem cells for clinical application
    • Seki T, Fukuda K. Methods of induced pluripotent stem cells for clinical application. World J Stem Cells. 2015;7(1):116–125.
    • (2015) World J Stem Cells , vol.7 , Issue.1 , pp. 116-125
    • Seki, T.1    Fukuda, K.2
  • 22
    • 55749089875 scopus 로고    scopus 로고
    • Efficient and rapid generation of induced pluripotent stem cells from human keratinocytes
    • Aasen T, Raya A, Barrero MJ, et al. Efficient and rapid generation of induced pluripotent stem cells from human keratinocytes. Nat Biotechnol. 2008;26(11):1276–1284.
    • (2008) Nat Biotechnol , vol.26 , Issue.11 , pp. 1276-1284
    • Aasen, T.1    Raya, A.2    Barrero, M.J.3
  • 23
    • 48349095740 scopus 로고    scopus 로고
    • Pluripotent stem cells induced from adult neural stem cells by reprogramming with two factors
    • Kim JB, Zaehres H, Wu G, et al. Pluripotent stem cells induced from adult neural stem cells by reprogramming with two factors. Nature. 2008;454(7204):646–650.
    • (2008) Nature , vol.454 , Issue.7204 , pp. 646-650
    • Kim, J.B.1    Zaehres, H.2    Wu, G.3
  • 24
    • 55049122748 scopus 로고    scopus 로고
    • Reprogramming of neural progenitor cells into induced pluripotent stem cells in the absence of exogenous Sox2 expression
    • Eminli S, Utikal J, Arnold K, et al. Reprogramming of neural progenitor cells into induced pluripotent stem cells in the absence of exogenous Sox2 expression. Stem Cells. 2008;26(10):2467–2474.
    • (2008) Stem Cells , vol.26 , Issue.10 , pp. 2467-2474
    • Eminli, S.1    Utikal, J.2    Arnold, K.3
  • 25
    • 84874063703 scopus 로고    scopus 로고
    • Hierarchy in reprogramming capacity in different tissue microenvironments: What we know and what we need to know
    • Liebau S, Mahaddalkar PU, Kestler HA, et al. Hierarchy in reprogramming capacity in different tissue microenvironments: what we know and what we need to know. Stem Cells Dev. 2013;22(5):695–706.
    • (2013) Stem Cells Dev , vol.22 , Issue.5 , pp. 695-706
    • Liebau, S.1    Mahaddalkar, P.U.2    Kestler, H.A.3
  • 26
    • 41949098160 scopus 로고    scopus 로고
    • Direct reprogramming of terminally differentiated mature B lymphocytes to pluripotency
    • Hanna J, Markoulaki S, Schorderet P, et al. Direct reprogramming of terminally differentiated mature B lymphocytes to pluripotency. Cell. 2008;133(2):250–264.
    • (2008) Cell , vol.133 , Issue.2 , pp. 250-264
    • Hanna, J.1    Markoulaki, S.2    Schorderet, P.3
  • 27
    • 50849142559 scopus 로고    scopus 로고
    • A high-efficiency system for the generation and study of human induced pluripotent stem cells
    • Maherali N, Ahfeldt T, Rigamonti A, et al. A high-efficiency system for the generation and study of human induced pluripotent stem cells. Cell Stem Cell. 2008;3(3):340–345.
    • (2008) Cell Stem Cell , vol.3 , Issue.3 , pp. 340-345
    • Maherali, N.1    Ahfeldt, T.2    Rigamonti, A.3
  • 28
    • 42649116102 scopus 로고    scopus 로고
    • Have we reached the point for in vivo rejuvenation?
    • Abramovich A, Muradian KK, Fraifeld VE. Have we reached the point for in vivo rejuvenation? Rejuvenation Res. 2008;11(2):489–492.
    • (2008) Rejuvenation Res , vol.11 , Issue.2 , pp. 489-492
    • Abramovich, A.1    Muradian, K.K.2    Fraifeld, V.E.3
  • 29
    • 84880203894 scopus 로고    scopus 로고
    • An epigenetic component of hematopoietic stem cell aging amenable to reprogramming into a young state
    • Wahlestedt M, Norddahl GL, Sten G, et al. An epigenetic component of hematopoietic stem cell aging amenable to reprogramming into a young state. Blood. 2013;121(21):4257–4264.
    • (2013) Blood , vol.121 , Issue.21 , pp. 4257-4264
    • Wahlestedt, M.1    Norddahl, G.L.2    Sten, G.3
  • 30
    • 84892492848 scopus 로고    scopus 로고
    • The aging signature: A hallmark of induced pluripotent stem cells?
    • Rohani L, Johnson AA, Arnold A, Stolzing A. The aging signature: a hallmark of induced pluripotent stem cells? Aging Cell. 2014;13(1):2–7.
    • (2014) Aging Cell , vol.13 , Issue.1 , pp. 2-7
    • Rohani, L.1    Johnson, A.A.2    Arnold, A.3    Stolzing, A.4
  • 31
    • 77952240404 scopus 로고    scopus 로고
    • Telomere rejuvenation during nuclear reprogramming
    • Marion RM, Blasco MA. Telomere rejuvenation during nuclear reprogramming. Curr Opin Genet Dev. 2010;20(2):190–196.
    • (2010) Curr Opin Genet Dev , vol.20 , Issue.2 , pp. 190-196
    • Marion, R.M.1    Blasco, M.A.2
  • 32
    • 81055124788 scopus 로고    scopus 로고
    • Mitochondrial-associated cell death mechanisms are reset to an embryonic-like state in aged donor-derived iPS cells harboring chromosomal aberrations
    • Prigione A, Hossini AM, Lichtner B, et al. Mitochondrial-associated cell death mechanisms are reset to an embryonic-like state in aged donor-derived iPS cells harboring chromosomal aberrations. PLoS One. 2011;6:e27352.
    • (2011) Plos One , vol.6
    • Prigione, A.1    Hossini, A.M.2    Lichtner, B.3
  • 33
    • 79960274488 scopus 로고    scopus 로고
    • Human induced pluripotent cells resemble embryonic stem cells demonstrating enhanced levels of DNA repair and efficacy of nonhomologous end-joining
    • Fan J, Robert C, Jang YY, et al. Human induced pluripotent cells resemble embryonic stem cells demonstrating enhanced levels of DNA repair and efficacy of nonhomologous end-joining. Mutat Res. 2011; 713(1–2):8–17.
    • (2011) Mutat Res , vol.713 , Issue.1-2 , pp. 8-17
    • Fan, J.1    Robert, C.2    Jang, Y.Y.3
  • 34
    • 84863243911 scopus 로고    scopus 로고
    • DNA repair in human pluripotent stem cells is distinct from that in nonpluripotent human cells
    • Luo LZ, Gopalakrishna-Pillai S, Nay SL, et al. DNA repair in human pluripotent stem cells is distinct from that in nonpluripotent human cells. PLoS One. 2012;7:e30541.
    • (2012) Plos One , vol.7
    • Luo, L.Z.1    Gopalakrishna-Pillai, S.2    Nay, S.L.3
  • 35
    • 46449094276 scopus 로고    scopus 로고
    • Dissecting direct reprogramming through integrative genomic analysis
    • Mikkelsen TS, Hanna J, Zhang X, et al. Dissecting direct reprogramming through integrative genomic analysis. Nature. 2008;454(7200):49–55.
    • (2008) Nature , vol.454 , Issue.7200 , pp. 49-55
    • Mikkelsen, T.S.1    Hanna, J.2    Zhang, X.3
  • 36
    • 67649222358 scopus 로고    scopus 로고
    • Induced pluripotent stem cells and embryonic stem cells are distinguished by gene expression signatures.
    • Chin MH, Mason MJ, Xie W, et al. Induced pluripotent stem cells and embryonic stem cells are distinguished by gene expression signatures. Cell Stem Cell. 2009;5(1):111–123.
    • (2009) Cell Stem Cell. , vol.5 , Issue.1 , pp. 111-123
    • Chin, M.H.1    Mason, M.J.2    Xie, W.3
  • 37
    • 64349106730 scopus 로고    scopus 로고
    • Targeted bisulfite sequencing reveals changes in DNA methylation associated with nuclear reprogramming
    • Deng J, Shoemaker R, Xie B, et al. Targeted bisulfite sequencing reveals changes in DNA methylation associated with nuclear reprogramming. Nat Biotechnol. 2009;27(4):353–360.
    • (2009) Nat Biotechnol , vol.27 , Issue.4 , pp. 353-360
    • Deng, J.1    Shoemaker, R.2    Xie, B.3
  • 38
    • 77957021225 scopus 로고    scopus 로고
    • DNA methylation and cellular reprogramming
    • De Carvalho DD, You JS, Jones PA. DNA methylation and cellular reprogramming. Trends Cell Biol. 2010;20(10):609–617.
    • (2010) Trends Cell Biol , vol.20 , Issue.10 , pp. 609-617
    • De Carvalho, D.D.1    You, J.S.2    Jones, P.A.3
  • 39
    • 79959992876 scopus 로고    scopus 로고
    • Epigenetic memory and preferential lineage-specific differentiation in induced pluripotent stem cells derived from human pancreatic islet beta cells
    • Bar-Nur O, Russ HA, Efrat S, Benvenisty N. Epigenetic memory and preferential lineage-specific differentiation in induced pluripotent stem cells derived from human pancreatic islet beta cells. Cell Stem Cell. 2011;9(1):17–23.
    • (2011) Cell Stem Cell , vol.9 , Issue.1 , pp. 17-23
    • Bar-Nur, O.1    Russ, H.A.2    Efrat, S.3    Benvenisty, N.4
  • 40
    • 84893385539 scopus 로고    scopus 로고
    • Zakian SM. “Epigenetic memory” phenomenon in induced pluripotent stem cells
    • Vaskova EA, Stekleneva AE, Medvedev SP, Zakian SM. “Epigenetic memory” phenomenon in induced pluripotent stem cells. Acta Naturae. 2013;5(4):15–21.
    • (2013) Acta Naturae , vol.5 , Issue.4 , pp. 15-21
    • Vaskova, E.A.1    Stekleneva, A.E.2    Medvedev, S.P.3
  • 41
    • 31144435271 scopus 로고    scopus 로고
    • Control of hepatic differentiation by activin/TGFβ signaling
    • Clotman F, Lemaigre FP. Control of hepatic differentiation by activin/TGFβ signaling. Cell Cycle. 2006;5(2):168–171.
    • (2006) Cell Cycle , vol.5 , Issue.2 , pp. 168-171
    • Clotman, F.1    Lemaigre, F.P.2
  • 42
    • 33847018050 scopus 로고    scopus 로고
    • Primary hepatocytes: Current understanding of the regulation of metabolic enzymes and transporter proteins, and pharmaceutical practice for the use of hepatocytes in metabolism, enzyme induction, transporter, clearance, and hepatotoxicity studies
    • Hewitt NJ, Lechon MJ, Houston JB, et al. Primary hepatocytes: current understanding of the regulation of metabolic enzymes and transporter proteins, and pharmaceutical practice for the use of hepatocytes in metabolism, enzyme induction, transporter, clearance, and hepatotoxicity studies. Drug Metab Rev. 2007;39(1):159–234.
    • (2007) Drug Metab Rev , vol.39 , Issue.1 , pp. 159-234
    • Hewitt, N.J.1    Lechon, M.J.2    Houston, J.B.3
  • 43
    • 84934437105 scopus 로고    scopus 로고
    • Generation of hepatocytes from human embryonic stem cells
    • Safinia N, Minger SL. Generation of hepatocytes from human embryonic stem cells. Methods Mol Biol. 2009;481:169–180.
    • (2009) Methods Mol Biol , vol.481 , pp. 169-180
    • Safinia, N.1    Minger, S.L.2
  • 44
    • 84934437418 scopus 로고    scopus 로고
    • An optimized method for cryopreservation of human hepatocytes
    • Terry C, Hughes RD. An optimized method for cryopreservation of human hepatocytes. Methods Mol Biol. 2009;481:25–34.
    • (2009) Methods Mol Biol , vol.481 , pp. 25-34
    • Terry, C.1    Hughes, R.D.2
  • 45
    • 70449534874 scopus 로고    scopus 로고
    • Efficient generation of hepatocyte-like cells from human induced pluripotent stem cells
    • Song Z, Cai J, Liu Y, et al. Efficient generation of hepatocyte-like cells from human induced pluripotent stem cells. Cell Res. 2009;19(11):1233–1242.
    • (2009) Cell Res , vol.19 , Issue.11 , pp. 1233-1242
    • Song, Z.1    Cai, J.2    Liu, Y.3
  • 46
    • 73449100783 scopus 로고    scopus 로고
    • Highly efficient generation of human hepatocyte-like cells from induced pluripotent stem cells
    • Si-Tayeb K, Noto FK, Nagaoka M, et al. Highly efficient generation of human hepatocyte-like cells from induced pluripotent stem cells. Hepatology. 2010;51(1):297–305.
    • (2010) Hepatology , vol.51 , Issue.1 , pp. 297-305
    • Si-Tayeb, K.1    Noto, F.K.2    Nagaoka, M.3
  • 47
    • 73449100456 scopus 로고    scopus 로고
    • Generation of functional human hepatic endoderm from human induced pluripotent stem cells
    • Sullivan GJ, Hay DC, Park IH, et al. Generation of functional human hepatic endoderm from human induced pluripotent stem cells. Hepatology. 2010;51(1):329–335.
    • (2010) Hepatology , vol.51 , Issue.1 , pp. 329-335
    • Sullivan, G.J.1    Hay, D.C.2    Park, I.H.3
  • 48
    • 16244400050 scopus 로고    scopus 로고
    • TGFbeta/activin/nodal signaling is necessary for the maintenance of pluripotency in human embryonic stem cells
    • James D, Levine AJ, Besser D, Hemmati-Brivanlou A. TGFbeta/activin/nodal signaling is necessary for the maintenance of pluripotency in human embryonic stem cells. Development (Cambridge, England). 2005;132(6):1273–1282.
    • (2005) Development (Cambridge, England) , vol.132 , Issue.6 , pp. 1273-1282
    • James, D.1    Levine, A.J.2    Besser, D.3    Hemmati-Brivanlou, A.4
  • 49
    • 27644486756 scopus 로고    scopus 로고
    • Activin/nodal and FGF pathways cooperate to maintain pluripotency of human embryonic stem cells
    • Vallier L, Alexander M, Pedersen RA. Activin/nodal and FGF pathways cooperate to maintain pluripotency of human embryonic stem cells. J Cell Sci. 2005;118(Pt 19):4495–4509.
    • (2005) J Cell Sci , vol.118 , pp. 4495-4509
    • Vallier, L.1    Alexander, M.2    Pedersen, R.A.3
  • 50
    • 24744446473 scopus 로고    scopus 로고
    • Activin A mediates growth inhibition and cell cycle arrest through Smads in human breast cancer cells
    • Burdette JE, Jeruss JS, Kurley SJ, et al. Activin A mediates growth inhibition and cell cycle arrest through Smads in human breast cancer cells. Cancer Res. 2005;65(17):7968–7975.
    • (2005) Cancer Res , vol.65 , Issue.17 , pp. 7968-7975
    • Burdette, J.E.1    Jeruss, J.S.2    Kurley, S.J.3
  • 51
    • 34547489197 scopus 로고    scopus 로고
    • P27KIP1 and GATA-1 are potential downstream molecules in activin A-induced differentiation and apoptosis pathways in CML cells
    • Fukuchi Y, Yamato K, Kawamura C, et al. p27KIP1 and GATA-1 are potential downstream molecules in activin A-induced differentiation and apoptosis pathways in CML cells. Oncol Rep. 2006;16(5):1099–1103.
    • (2006) Oncol Rep , vol.16 , Issue.5 , pp. 1099-1103
    • Fukuchi, Y.1    Yamato, K.2    Kawamura, C.3
  • 52
    • 33746766204 scopus 로고    scopus 로고
    • Transforming growth factor-beta1 and activin A generate antiproliferative signaling in thyroid cancer cells
    • Matsuo SE, Leoni SG, Colquhoun A, Kimura ET. Transforming growth factor-beta1 and activin A generate antiproliferative signaling in thyroid cancer cells. J Endocrinol. 2006;190(1):141–150.
    • (2006) J Endocrinol , vol.190 , Issue.1 , pp. 141-150
    • Matsuo, S.E.1    Leoni, S.G.2    Colquhoun, A.3    Kimura, E.T.4
  • 53
    • 79951869792 scopus 로고    scopus 로고
    • The role of activin/nodal and Wnt signaling in endoderm formation
    • Payne C, King J, Hay D. The role of activin/nodal and Wnt signaling in endoderm formation. Vitam Horm. 2011;85:207–216.
    • (2011) Vitam Horm , vol.85 , pp. 207-216
    • Payne, C.1    King, J.2    Hay, D.3
  • 54
    • 78649847411 scopus 로고    scopus 로고
    • Smad2 mediates activin/nodal signaling in mesendoderm differentiation of mouse embryonic stem cells
    • Fei T, Zhu S, Xia K, et al. Smad2 mediates activin/nodal signaling in mesendoderm differentiation of mouse embryonic stem cells. Cell Res. 2010;20(12):1306–1318.
    • (2010) Cell Res , vol.20 , Issue.12 , pp. 1306-1318
    • Fei, T.1    Zhu, S.2    Xia, K.3
  • 55
    • 2342424743 scopus 로고    scopus 로고
    • Development of definitive endoderm from embryonic stem cells in culture
    • Kubo A, Shinozaki K, Shannon JM, et al. Development of definitive endoderm from embryonic stem cells in culture. Development. 2004;131(7):1651–1662.
    • (2004) Development , vol.131 , Issue.7 , pp. 1651-1662
    • Kubo, A.1    Shinozaki, K.2    Shannon, J.M.3
  • 56
    • 84903270261 scopus 로고    scopus 로고
    • Activin A supplement in the hESCs culture enhances the endoderm differentiation efficiency
    • Guo S, Mao X, He F, et al. Activin A supplement in the hESCs culture enhances the endoderm differentiation efficiency. Cell Biol Int. 2014; 38(7):849–856.
    • (2014) Cell Biol Int , vol.38 , Issue.7 , pp. 849-856
    • Guo, S.1    Mao, X.2    He, F.3
  • 57
    • 33747614295 scopus 로고    scopus 로고
    • Activin A maintains self-renewal and regulates fibroblast growth factor, Wnt, and bone morphogenic protein pathways in human embryonic stem cells
    • Xiao L, Yuan X, Sharkis SJ. Activin A maintains self-renewal and regulates fibroblast growth factor, Wnt, and bone morphogenic protein pathways in human embryonic stem cells. Stem Cells. 2006;24(6):1476–1486.
    • (2006) Stem Cells , vol.24 , Issue.6 , pp. 1476-1486
    • Xiao, L.1    Yuan, X.2    Sharkis, S.J.3
  • 58
    • 84933675275 scopus 로고    scopus 로고
    • Activin A can induce definitive endoderm differentiation from human parthenogenetic embryonic stem cells
    • Wang Z, Li W, Chen T, et al. Activin A can induce definitive endoderm differentiation from human parthenogenetic embryonic stem cells. Biotechnol Lett. 2015;37(8):1711–1717.
    • (2015) Biotechnol Lett , vol.37 , Issue.8 , pp. 1711-1717
    • Wang, Z.1    Li, W.2    Chen, T.3
  • 59
    • 79953271201 scopus 로고    scopus 로고
    • Activin A maintains pluripotency markers and proliferative potential of human induced pluripotent stem cells
    • Tomizawa M, Shinozaki F, Sugiyama T, et al. Activin A maintains pluripotency markers and proliferative potential of human induced pluripotent stem cells. Exp Ther Med. 2011;2(3):405–408.
    • (2011) Exp Ther Med , vol.2 , Issue.3 , pp. 405-408
    • Tomizawa, M.1    Shinozaki, F.2    Sugiyama, T.3
  • 60
    • 28644448149 scopus 로고    scopus 로고
    • Efficient differentiation of human embryonic stem cells to definitive endoderm
    • D’Amour KA, Agulnick AD, Eliazer S, et al. Efficient differentiation of human embryonic stem cells to definitive endoderm. Nat Biotechnol. 2005;23(12):1534–1541.
    • (2005) Nat Biotechnol , vol.23 , Issue.12 , pp. 1534-1541
    • D’Amour, K.A.1    Agulnick, A.D.2    Eliazer, S.3
  • 61
    • 84862824246 scopus 로고    scopus 로고
    • Rapid generation of mature hepatocyte-like cells from human induced pluripotent stem cells by an efficient three-step protocol
    • Chen YF, Tseng CY, Wang HW, et al. Rapid generation of mature hepatocyte-like cells from human induced pluripotent stem cells by an efficient three-step protocol. Hepatology. 2012;55(4):1193–1203.
    • (2012) Hepatology , vol.55 , Issue.4 , pp. 1193-1203
    • Chen, Y.F.1    Tseng, C.Y.2    Wang, H.W.3
  • 62
    • 84908018464 scopus 로고    scopus 로고
    • Efficient differentiation of human induced pluripotent stem cell (HiPSC) derived hepatocyte-like cells on hMSCs feeder
    • Mobarra N, Soleimani M, Kouhkan F, et al. Efficient differentiation of human induced pluripotent stem cell (hiPSC) derived hepatocyte-like cells on hMSCs feeder. Int J Hematol Oncol Stem Cell Res. 2014;8(4):20–29.
    • (2014) Int J Hematol Oncol Stem Cell Res , vol.8 , Issue.4 , pp. 20-29
    • Mobarra, N.1    Soleimani, M.2    Kouhkan, F.3
  • 63
    • 84860745261 scopus 로고    scopus 로고
    • Highly efficient generation of definitive endoderm lineage from human induced pluripotent stem cells
    • Sekine K, Takebe T, Suzuki Y, Kamiya A, Nakauchi H, Taniguchi H. Highly efficient generation of definitive endoderm lineage from human induced pluripotent stem cells. Transplant Proc. 2012;44(4):1127–1129.
    • (2012) Transplant Proc , vol.44 , Issue.4 , pp. 1127-1129
    • Sekine, K.1    Takebe, T.2    Suzuki, Y.3    Kamiya, A.4    Nakauchi, H.5    Taniguchi, H.6
  • 64
    • 84903378721 scopus 로고    scopus 로고
    • High efficient differentiation of functional hepatocytes from porcine induced pluripotent stem cells
    • Ao Y, Mich-Basso JD, Lin B, Yang L. High efficient differentiation of functional hepatocytes from porcine induced pluripotent stem cells. PLoS One. 2014;9(6):e100417.
    • (2014) Plos One , vol.9 , Issue.6
    • Ao, Y.1    Mich-Basso, J.D.2    Lin, B.3    Yang, L.4
  • 65
    • 0033580985 scopus 로고    scopus 로고
    • Initiation of mammalian liver development from endoderm by fibroblast growth factors
    • Jung J, Zheng M, Goldfarb M, Zaret KS. Initiation of mammalian liver development from endoderm by fibroblast growth factors. Science. 1999;284(5422):1998–2003.
    • (1999) Science , vol.284 , Issue.5422 , pp. 1998-2003
    • Jung, J.1    Zheng, M.2    Goldfarb, M.3    Zaret, K.S.4
  • 66
    • 0035423751 scopus 로고    scopus 로고
    • Distinct mesodermal signals, including BMPs from the septum transversum mesenchyme, are required in combination for hepatogenesis from the endoderm
    • Rossi JM, Dunn NR, Hogan BL, Zaret KS. Distinct mesodermal signals, including BMPs from the septum transversum mesenchyme, are required in combination for hepatogenesis from the endoderm. Genes Dev. 2001;15(15):1998–2009.
    • (2001) Genes Dev , vol.15 , Issue.15 , pp. 1998-2009
    • Rossi, J.M.1    Dunn, N.R.2    Hogan, B.L.3    Zaret, K.S.4
  • 67
    • 0028899952 scopus 로고
    • Scatter factor/hepatocyte growth factor is essential for liver development
    • Schmidt C, Bladt F, Goedecke S, et al. Scatter factor/hepatocyte growth factor is essential for liver development. Nature. 1995;373(6516):699–702.
    • (1995) Nature , vol.373 , Issue.6516 , pp. 699-702
    • Schmidt, C.1    Bladt, F.2    Goedecke, S.3
  • 68
    • 73449111266 scopus 로고    scopus 로고
    • Developing c-MET pathway inhibitors for cancer therapy: Progress and challenges
    • Liu X, Newton RC, Scherle PA. Developing c-MET pathway inhibitors for cancer therapy: progress and challenges. Trends Mol Med. 2010;16(1):37–45.
    • (2010) Trends Mol Med , vol.16 , Issue.1 , pp. 37-45
    • Liu, X.1    Newton, R.C.2    Scherle, P.A.3
  • 69
    • 0035831059 scopus 로고    scopus 로고
    • Oncostatin M and hepatocyte growth factor induce hepatic maturation via distinct signaling pathways
    • Kamiya A, Kinoshita T, Miyajima A. Oncostatin M and hepatocyte growth factor induce hepatic maturation via distinct signaling pathways. FEBS Lett. 2001;492(1–2):90–94.
    • (2001) FEBS Lett , vol.492 , Issue.1-2 , pp. 90-94
    • Kamiya, A.1    Kinoshita, T.2    Miyajima, A.3
  • 70
    • 0038045136 scopus 로고    scopus 로고
    • EGF-, and dexamethasone-induced gene expression patterns during formation of tissue in hepatic organoid cultures
    • Michalopoulos GK, Bowen WC, Mule K, Luo J. HGF-, EGF-, and dexamethasone-induced gene expression patterns during formation of tissue in hepatic organoid cultures. Gene Expr. 2003;11(2):55–75.
    • (2003) Gene Expr , vol.11 , Issue.2 , pp. 55-75
    • Michalopoulos, G.K.1    Bowen, W.C.2    Mule, K.3    Luo, J.H.4
  • 71
    • 0037672369 scopus 로고    scopus 로고
    • Role for growth factors and extracellular matrix in controlling differentiation of prospectively isolated hepatic stem cells
    • Suzuki A, Iwama A, Miyashita H, et al. Role for growth factors and extracellular matrix in controlling differentiation of prospectively isolated hepatic stem cells. Development. 2003;130(11):2513–2524.
    • (2003) Development , vol.130 , Issue.11 , pp. 2513-2524
    • Suzuki, A.1    Iwama, A.2    Miyashita, H.3
  • 72
    • 0033658759 scopus 로고    scopus 로고
    • Retroviral gene transfer of signaling molecules into murine fetal hepatocytes defines distinct roles for the STAT3 and ras pathways during hepatic development
    • Ito Y, Matsui T, Kamiya A, et al. Retroviral gene transfer of signaling molecules into murine fetal hepatocytes defines distinct roles for the STAT3 and ras pathways during hepatic development. Hepatology. 2000;32(6):1370–1376.
    • (2000) Hepatology , vol.32 , Issue.6 , pp. 1370-1376
    • Ito, Y.1    Matsui, T.2    Kamiya, A.3
  • 73
    • 0036500155 scopus 로고    scopus 로고
    • K-Ras mediates cytokine-induced formation of E-cadherin-based adherens junctions during liver development
    • Matsui T, Kinoshita T, Morikawa Y, et al. K-Ras mediates cytokine-induced formation of E-cadherin-based adherens junctions during liver development. EMBO J. 2002;21(5):1021–1030.
    • (2002) EMBO J , vol.21 , Issue.5 , pp. 1021-1030
    • Matsui, T.1    Kinoshita, T.2    Morikawa, Y.3
  • 74
    • 34247508496 scopus 로고    scopus 로고
    • Oncostatin M induces upregulation of claudin-2 in rodent hepatocytes coinciding with changes in morphology and function of tight junctions
    • Imamura M, Kojima T, Lan M, et al. Oncostatin M induces upregulation of claudin-2 in rodent hepatocytes coinciding with changes in morphology and function of tight junctions. Exp Cell Res. 2007;313(9):1951–1962.
    • (2007) Exp Cell Res , vol.313 , Issue.9 , pp. 1951-1962
    • Imamura, M.1    Kojima, T.2    Lan, M.3
  • 75
    • 82255169402 scopus 로고    scopus 로고
    • Efficient derivation of functional hepatocytes from mouse induced pluripotent stem cells by a combination of cytokines and sodium butyrate
    • Zhang Q, Yang Y, Zhang J, et al. Efficient derivation of functional hepatocytes from mouse induced pluripotent stem cells by a combination of cytokines and sodium butyrate. Chin Med J. 2011;124(22):3786–3793.
    • (2011) Chin Med J , vol.124 , Issue.22 , pp. 3786-3793
    • Zhang, Q.1    Yang, Y.2    Zhang, J.3
  • 76
    • 0023026691 scopus 로고
    • Glucocorticoid-dependent expression of the albumin gene in adult rat hepatocytes
    • Nawa K, Nakamura T, Kumatori A, Noda C, Ichihara A. Glucocorticoid-dependent expression of the albumin gene in adult rat hepatocytes. J Biol Chem. 1986;261(36):16883–16888.
    • (1986) J Biol Chem , vol.261 , Issue.36 , pp. 16883-16888
    • Nawa, K.1    Nakamura, T.2    Kumatori, A.3    Noda, C.4    Ichihara, A.5
  • 77
    • 0026650737 scopus 로고
    • Regulation of albumin expression in fetal rat hepatocytes cultured under proliferative conditions: Role of epidermal growth factor and hormones
    • de Juan C, Benito M, Fabregat I. Regulation of albumin expression in fetal rat hepatocytes cultured under proliferative conditions: role of epidermal growth factor and hormones. J Cell Physiol. 1992;152(1):95–101.
    • (1992) J Cell Physiol , vol.152 , Issue.1 , pp. 95-101
    • De Juan, C.1    Benito, M.2    Fabregat, I.3
  • 78
    • 0030889354 scopus 로고    scopus 로고
    • Marrow stromal cells as stem cells for nonhematopoietic tissues
    • Prockop DJ. Marrow stromal cells as stem cells for nonhematopoietic tissues. Science. 1997;276(5309):71–74.
    • (1997) Science , vol.276 , Issue.5309 , pp. 71-74
    • Prockop, D.J.1
  • 79
    • 0033553591 scopus 로고    scopus 로고
    • Bone marrow as a potential source of hepatic oval cells
    • Petersen BE, Bowen WC, Patrene KD, et al. Bone marrow as a potential source of hepatic oval cells. Science. 1999;284(5417):1168–1170.
    • (1999) Science , vol.284 , Issue.5417 , pp. 1168-1170
    • Petersen, B.E.1    Bowen, W.C.2    Patrene, K.D.3
  • 80
    • 0034691557 scopus 로고    scopus 로고
    • Hepatocytes from non-hepatic adult stem cells
    • Alison MR, Poulsom R, Jeffery R, et al. Hepatocytes from non-hepatic adult stem cells. Nature. 2000;406(6793):257.
    • (2000) Nature , vol.406 , Issue.6793
    • Alison, M.R.1    Poulsom, R.2    Jeffery, R.3
  • 81
    • 0033694301 scopus 로고    scopus 로고
    • Purified hematopoietic stem cells can differentiate into hepatocytes in vivo
    • Lagasse E, Connors H, Al-Dhalimy M, et al. Purified hematopoietic stem cells can differentiate into hepatocytes in vivo. Nat Med. 2000;6(11):1229–1234.
    • (2000) Nat Med , vol.6 , Issue.11 , pp. 1229-1234
    • Lagasse, E.1    Connors, H.2    Al-Dhalimy, M.3
  • 82
    • 0036106054 scopus 로고    scopus 로고
    • Multipotent adult progenitor cells from bone marrow differentiate into functional hepatocyte-like cells
    • Schwartz RE, Reyes M, Koodie L, et al. Multipotent adult progenitor cells from bone marrow differentiate into functional hepatocyte-like cells. J Clin Invest. 2002;109(10):1291–1302.
    • (2002) J Clin Invest , vol.109 , Issue.10 , pp. 1291-1302
    • Schwartz, R.E.1    Reyes, M.2    Koodie, L.3
  • 83
    • 33646152348 scopus 로고    scopus 로고
    • A population of very small embryonic-like (VSEL) CXCR4(+)SSEA-1(+)Oct-4+ stem cells identified in adult bone marrow
    • Kucia M, Reca R, Campbell FR, et al. A population of very small embryonic-like (VSEL) CXCR4(+)SSEA-1(+)Oct-4+ stem cells identified in adult bone marrow. Leukemia. 2006;20(5):857–869.
    • (2006) Leukemia , vol.20 , Issue.5 , pp. 857-869
    • Kucia, M.1    Reca, R.2    Campbell, F.R.3
  • 84
    • 0033515827 scopus 로고    scopus 로고
    • Multilineage potential of adult human mesenchymal stem cells
    • Pittenger MF, Mackay AM, Beck SC, et al. Multilineage potential of adult human mesenchymal stem cells. Science. 1999;284(5411):143–147.
    • (1999) Science , vol.284 , Issue.5411 , pp. 143-147
    • Pittenger, M.F.1    Mackay, A.M.2    Beck, S.C.3
  • 85
    • 36249021493 scopus 로고    scopus 로고
    • Concise review: Mesenchymal stem/multipotent stromal cells: The state of transdifferentiation and modes of tissue repair – current views
    • Phinney DG, Prockop DJ. Concise review: mesenchymal stem/multipotent stromal cells: the state of transdifferentiation and modes of tissue repair – current views. Stem Cells. 2007;25(11):2896–2902.
    • (2007) Stem Cells , vol.25 , Issue.11 , pp. 2896-2902
    • Phinney, D.G.1    Prockop, D.J.2
  • 86
    • 84904469260 scopus 로고    scopus 로고
    • Cellular transplantation for liver diseases
    • Jameson E. Cellular transplantation for liver diseases. Gastroen Res. 2008;1(1):8–13.
    • (2008) Gastroen Res , vol.1 , Issue.1 , pp. 8-13
    • Jameson, E.1
  • 87
    • 0035067539 scopus 로고    scopus 로고
    • Multilineage cells from human adipose tissue: Implications for cell-based therapies
    • Zuk PA, Zhu M, Mizuno H, et al. Multilineage cells from human adipose tissue: implications for cell-based therapies. Tissue Eng. 2001;7(2):211–228.
    • (2001) Tissue Eng , vol.7 , Issue.2 , pp. 211-228
    • Zuk, P.A.1    Zhu, M.2    Mizuno, H.3
  • 88
    • 33750121487 scopus 로고    scopus 로고
    • Hepatogenic differentiation of human mesenchymal stem cells from adipose tissue in comparison with bone marrow mesenchymal stem cells
    • Talens-Visconti R, Bonora A, Jover R, et al. Hepatogenic differentiation of human mesenchymal stem cells from adipose tissue in comparison with bone marrow mesenchymal stem cells. World J Gastroenterol. 2006;12(36):5834–5845.
    • (2006) World J Gastroenterol , vol.12 , Issue.36 , pp. 5834-5845
    • Talens-Visconti, R.1    Bonora, A.2    Jover, R.3
  • 89
    • 70449721168 scopus 로고    scopus 로고
    • Expression of liver-specific markers in naive adipose-derived mesenchymal stem cells
    • Zemel R, Bachmetov L, Ad-El D, Abraham A, Tur-Kaspa R. Expression of liver-specific markers in naive adipose-derived mesenchymal stem cells. Liver Int. 2009;29(9):1326–1337.
    • (2009) Liver Int , vol.29 , Issue.9 , pp. 1326-1337
    • Zemel, R.1    Bachmetov, L.2    Ad-El, D.3    Abraham, A.4    Tur-Kaspa, R.5
  • 90
    • 39749171878 scopus 로고    scopus 로고
    • Native umbilical cord matrix stem cells express hepatic markers and differentiate into hepatocyte-like cells
    • Campard D, Lysy PA, Najimi M, Sokal EM. Native umbilical cord matrix stem cells express hepatic markers and differentiate into hepatocyte-like cells. Gastroenterology. 2008;134(3):833–848.
    • (2008) Gastroenterology , vol.134 , Issue.3 , pp. 833-848
    • Campard, D.1    Lysy, P.A.2    Najimi, M.3    Sokal, E.M.4
  • 91
    • 70849088109 scopus 로고    scopus 로고
    • Differentiation of mesenchymal stromal cells derived from umbilical cord Wharton’s jelly into hepatocyte-like cells
    • Zhang YN, Lie PC, Wei X. Differentiation of mesenchymal stromal cells derived from umbilical cord Wharton’s jelly into hepatocyte-like cells. Cytotherapy. 2009;11(5):548–558.
    • (2009) Cytotherapy , vol.11 , Issue.5 , pp. 548-558
    • Zhang, Y.N.1    Lie, P.C.2    Wei, X.3
  • 92
    • 17044416830 scopus 로고    scopus 로고
    • In vitro differentiation of human umbilical cord blood-derived mesenchymal stem cells into hepatocyte-like cells
    • Hong SH, Gang EJ, Jeong JA, et al. In vitro differentiation of human umbilical cord blood-derived mesenchymal stem cells into hepatocyte-like cells. Biochem Biophys Res Commun. 2005;330(4): 1153–1161.
    • (2005) Biochem Biophys Res Commun , vol.330 , Issue.4 , pp. 1153-1161
    • Hong, S.H.1    Gang, E.J.2    Jeong, J.A.3
  • 93
    • 77956505320 scopus 로고    scopus 로고
    • In vitro differentiation of unrestricted somatic stem cells into functional hepatic-like cells displaying a hepatocyte-like glucose metabolism
    • Waclawczyk S, Buchheiser A, Flogel U, Radke TF, Kögler G. In vitro differentiation of unrestricted somatic stem cells into functional hepatic-like cells displaying a hepatocyte-like glucose metabolism. J Cell Physiol. 2010;225(2):545–554.
    • (2010) J Cell Physiol , vol.225 , Issue.2 , pp. 545-554
    • Waclawczyk, S.1    Buchheiser, A.2    Flogel, U.3    Radke, T.F.4    Kögler, G.5
  • 94
    • 76449095261 scopus 로고    scopus 로고
    • Deciduous and permanent dental pulp mesenchymal cells acquire hepatic morphologic and functional features in vitro
    • Ishkitiev N, Yaegaki K, Calenic B, et al. Deciduous and permanent dental pulp mesenchymal cells acquire hepatic morphologic and functional features in vitro. J Endod. 2010;36(3):469–474.
    • (2010) J Endod , vol.36 , Issue.3 , pp. 469-474
    • Ishkitiev, N.1    Yaegaki, K.2    Calenic, B.3
  • 95
    • 0037064554 scopus 로고    scopus 로고
    • Miyajima A. Cytokine regulation of liver development.
    • Kinoshita T, Miyajima A. Cytokine regulation of liver development. Biochim Biophys Acta. 2002;1592(3):303–312.
    • (2002) Biochim Biophys Acta. , vol.1592 , Issue.3 , pp. 303-312
    • Kinoshita, T.1
  • 96
    • 17844371936 scopus 로고    scopus 로고
    • Duncan SA. Embryonic development of the liver.
    • Zhao R, Duncan SA. Embryonic development of the liver. Hepatology. 2005;41(5):956–967.
    • (2005) Hepatology. , vol.41 , Issue.5 , pp. 956-967
    • Zhao, R.1
  • 97
    • 34547461813 scopus 로고    scopus 로고
    • Adipose tissue-derived mesenchymal stem cells as a source of human hepatocytes
    • Banas A, Teratani T, Yamamoto Y, et al. Adipose tissue-derived mesenchymal stem cells as a source of human hepatocytes. Hepatology. 2007;46(1):219–228.
    • (2007) Hepatology , vol.46 , Issue.1 , pp. 219-228
    • Banas, A.1    Teratani, T.2    Yamamoto, Y.3
  • 98
    • 65249105997 scopus 로고    scopus 로고
    • Mesenchymal stromal cells multipotency and plasticity: Induction toward the hepatic lineage
    • Saulnier N, Lattanzi W, Puglisi MA, et al. Mesenchymal stromal cells multipotency and plasticity: induction toward the hepatic lineage. Eur Rev Med Pharmacol Sci. 2009;13(Suppl 1):71–78.
    • (2009) Eur Rev Med Pharmacol Sci , vol.13 , pp. 71-78
    • Saulnier, N.1    Lattanzi, W.2    Puglisi, M.A.3
  • 99
    • 33846829643 scopus 로고    scopus 로고
    • Human mesenchymal stem cells from adipose tissue: Differentiation into hepatic lineage
    • Taléns-Visconti R, Bonora A, Jover R, et al. Human mesenchymal stem cells from adipose tissue: differentiation into hepatic lineage. Toxicol In Vitro. 2007;21(2):324–329.
    • (2007) Toxicol in Vitro , vol.21 , Issue.2 , pp. 324-329
    • Taléns-Visconti, R.1    Bonora, A.2    Jover, R.3
  • 100
    • 33845931751 scopus 로고    scopus 로고
    • Hepatic differentiation potential of commercially available human mesenchymal stem cells
    • Ong SY, Dai H, Leong KW. Hepatic differentiation potential of commercially available human mesenchymal stem cells. Tissue Eng. 2006;12(12):3477–3485.
    • (2006) Tissue Eng , vol.12 , Issue.12 , pp. 3477-3485
    • Ong, S.Y.1    Dai, H.2    Leong, K.W.3
  • 101
    • 77952956204 scopus 로고    scopus 로고
    • A comparative study of proliferation and hepatic differentiation of human adipose-derived stem cells
    • Coradeghini R, Guida C, Scanarotti C, et al. A comparative study of proliferation and hepatic differentiation of human adipose-derived stem cells. Cells Tissues Organs. 2010;191(6):466–477.
    • (2010) Cells Tissues Organs , vol.191 , Issue.6 , pp. 466-477
    • Coradeghini, R.1    Guida, C.2    Scanarotti, C.3
  • 102
    • 34247231009 scopus 로고    scopus 로고
    • Chromatin remodeling agent trichostatin A: A key-factor in the hepatic differentiation of human mesenchymal stem cells derived of adult bone marrow
    • Snykers S, Vanhaecke T, De Becker A, et al. Chromatin remodeling agent trichostatin A: a key-factor in the hepatic differentiation of human mesenchymal stem cells derived of adult bone marrow. BMC Dev Biol. 2007;7:24.
    • (2007) BMC Dev Biol , vol.7
    • Snykers, S.1    Vanhaecke, T.2    De Becker, A.3
  • 103
    • 40349085915 scopus 로고    scopus 로고
    • A comparative analysis of the transcriptome and signal pathways in hepatic differentiation of human adipose mesenchymal stem cells
    • Yamamoto Y, Banas A, Murata S, et al. A comparative analysis of the transcriptome and signal pathways in hepatic differentiation of human adipose mesenchymal stem cells. FEBS J. 2008;275(6):1260–1273.
    • (2008) FEBS J , vol.275 , Issue.6 , pp. 1260-1273
    • Yamamoto, Y.1    Banas, A.2    Murata, S.3
  • 104
    • 78650288413 scopus 로고    scopus 로고
    • Molecular mechanisms underlying human adipose tissue-derived stromal cells differentiation into a hepatocyte-like phenotype
    • Saulnier N, Piscaglia AC, Puglisi MA, et al. Molecular mechanisms underlying human adipose tissue-derived stromal cells differentiation into a hepatocyte-like phenotype. Dig Liver Dis. 2010;42(12):895–901.
    • (2010) Dig Liver Dis , vol.42 , Issue.12 , pp. 895-901
    • Saulnier, N.1    Piscaglia, A.C.2    Puglisi, M.A.3
  • 105
    • 63849329673 scopus 로고    scopus 로고
    • Hepatocyte differentiation of mesenchymal stem cells from human adipose tissue in vitro promotes hepatic integration in vivo
    • Aurich H, Sgodda M, Kaltwaßer P, et al. Hepatocyte differentiation of mesenchymal stem cells from human adipose tissue in vitro promotes hepatic integration in vivo. Gut. 2009;58(4):570–581.
    • (2009) Gut , vol.58 , Issue.4 , pp. 570-581
    • Aurich, H.1    Sgodda, M.2    Kaltwaßer, P.3
  • 106
    • 84859230268 scopus 로고    scopus 로고
    • Hepatogenic differentiation of mesenchymal stem cells in a rat model of thioacetamide-induced liver cirrhosis
    • Hwang S, Hong HN, Kim HS, et al. Hepatogenic differentiation of mesenchymal stem cells in a rat model of thioacetamide-induced liver cirrhosis. Cell Biol Int. 2012;36(3):279–288.
    • (2012) Cell Biol Int , vol.36 , Issue.3 , pp. 279-288
    • Hwang, S.1    Hong, H.N.2    Kim, H.S.3
  • 107
    • 84862292901 scopus 로고    scopus 로고
    • In vivo hepatic differentiation of mesenchymal stem cells from human umbilical cord blood after transplantation into mice with liver injury
    • Yu J, Cao H, Yang J, et al. In vivo hepatic differentiation of mesenchymal stem cells from human umbilical cord blood after transplantation into mice with liver injury. Biochem Biophys Res Commun. 2012;422(4):539–545.
    • (2012) Biochem Biophys Res Commun , vol.422 , Issue.4 , pp. 539-545
    • Yu, J.1    Cao, H.2    Yang, J.3
  • 108
    • 33745503987 scopus 로고    scopus 로고
    • Mesenchymal stem cells reside in virtually all post-natal organs and tissues
    • da Silva Meirelles L, Chagastelles PC, Nardi NB. Mesenchymal stem cells reside in virtually all post-natal organs and tissues. J Cell Sci. 2006;119(Pt 11):2204–2213.
    • (2006) J Cell Sci , vol.119 , pp. 2204-2213
    • Da Silva Meirelles, L.1    Chagastelles, P.C.2    Nardi, N.B.3
  • 109
    • 34249086033 scopus 로고    scopus 로고
    • Capability of human mesenchymal cells isolated from different sources to differentiation into tissues of mesodermal origin
    • Suzdal’tseva YG, Burunova VV, Vakhrushev IV, Yarygin VN, Yarygin KN. Capability of human mesenchymal cells isolated from different sources to differentiation into tissues of mesodermal origin. Bull Exp Biol Med. 2007;143(1):114–121.
    • (2007) Bull Exp Biol Med , vol.143 , Issue.1 , pp. 114-121
    • Suzdal’Tseva, Y.G.1    Burunova, V.V.2    Vakhrushev, I.V.3    Yarygin, V.N.4    Yarygin, K.N.5
  • 110
    • 50849139576 scopus 로고    scopus 로고
    • A perivascular origin of mesenchymal stem cells in multiple human organs
    • Crisan M, Yap S, Casteilla L, et al. A perivascular origin of mesenchymal stem cells in multiple human organs. Cell Stem Cell. 2008;3(3):301–313.
    • (2008) Cell Stem Cell , vol.3 , Issue.3 , pp. 301-313
    • Crisan, M.1    Yap, S.2    Casteilla, L.3
  • 112
    • 33745109367 scopus 로고    scopus 로고
    • Comparative study of adult human skin fibroblasts and umbilical fibroblast-like cells
    • Yarygin KN, Suzdal’tseva YG, Burunova VV, et al. Comparative study of adult human skin fibroblasts and umbilical fibroblast-like cells. Bull Exp Biol Med. 2006;141(1):161–166.
    • (2006) Bull Exp Biol Med , vol.141 , Issue.1 , pp. 161-166
    • Yarygin, K.N.1    Suzdal’Tseva, Y.G.2    Burunova, V.V.3
  • 113
    • 33947108918 scopus 로고    scopus 로고
    • Cytofluorometric analysis of phenotypes of human bone marrow and umbilical fibroblast-like cells
    • Lupatov AY, Karalkin PA, Suzdal’tseva YG, et al. Cytofluorometric analysis of phenotypes of human bone marrow and umbilical fibroblast-like cells. Bull Exp Biol Med. 2006;142(4):521–526.
    • (2006) Bull Exp Biol Med , vol.142 , Issue.4 , pp. 521-526
    • Lupatov, A.Y.1    Karalkin, P.A.2    Suzdal’Tseva, Y.G.3
  • 115
    • 84952714316 scopus 로고    scopus 로고
    • Comparative analysis of the expression of surface markers on fibroblasts and fibroblast-like cells isolated from different human tissues
    • Lupatov AY, Vdovin AS, Vakhrushev IV, Poltavtseva RA, Yarygin KN. Comparative analysis of the expression of surface markers on fibroblasts and fibroblast-like cells isolated from different human tissues. Bull Exp Biol Med. 2015;158(4):537–543.
    • (2015) Bull Exp Biol Med , vol.158 , Issue.4 , pp. 537-543
    • Lupatov, A.Y.1    Vdovin, A.S.2    Vakhrushev, I.V.3    Poltavtseva, R.A.4    Yarygin, K.N.5
  • 116
    • 20344365575 scopus 로고    scopus 로고
    • Isolation and characterization of multipotent skin-derived precursors from human skin
    • Toma JG, McKenzie IA, Bagli D, Miller FD. Isolation and characterization of multipotent skin-derived precursors from human skin. Stem Cells. 2005;23(6):727–737.
    • (2005) Stem Cells , vol.23 , Issue.6 , pp. 727-737
    • Toma, J.G.1    McKenzie, I.A.2    Bagli, D.3    Miller, F.D.4
  • 117
    • 33645400158 scopus 로고    scopus 로고
    • Comparative characterization of hair follicle dermal stem cells and bone marrow mesenchymal stem cells
    • Hoogduijn MJ, Gorjup E, Genever PG. Comparative characterization of hair follicle dermal stem cells and bone marrow mesenchymal stem cells. Stem Cells Dev. 2006;15(1):49–60.
    • (2006) Stem Cells Dev , vol.15 , Issue.1 , pp. 49-60
    • Hoogduijn, M.J.1    Gorjup, E.2    Genever, P.G.3
  • 118
    • 33748889106 scopus 로고    scopus 로고
    • Towards the development of a pragmatic technique for isolating and differentiating nestin-positive cells from human scalp skin into neuronal and glial cell populations: Generating neurons from human skin?
    • Kruse C, Bodo E, Petschnik AE, Danner S, Tiede S, Paus R. Towards the development of a pragmatic technique for isolating and differentiating nestin-positive cells from human scalp skin into neuronal and glial cell populations: generating neurons from human skin? Exp Dermatol. 2006;15(10):794–800.
    • (2006) Exp Dermatol , vol.15 , Issue.10 , pp. 794-800
    • Kruse, C.1    Bodo, E.2    Petschnik, A.E.3    Danner, S.4    Tiede, S.5    Paus, R.6
  • 120
    • 79951669519 scopus 로고    scopus 로고
    • Functional properties of mesenchymal stem cells labeled with magnetic microparticles in vitro and analysis of their distribution after transplantation
    • Konieva AA, Kholodenko IV, Shragina OA, et al. Functional properties of mesenchymal stem cells labeled with magnetic microparticles in vitro and analysis of their distribution after transplantation. Bull Exp Biol Med. 2010;150(1):131–136.
    • (2010) Bull Exp Biol Med , vol.150 , Issue.1 , pp. 131-136
    • Konieva, A.A.1    Kholodenko, I.V.2    Shragina, O.A.3
  • 121
    • 77953825335 scopus 로고    scopus 로고
    • Multilineage differentiation potential of fibroblast-like stromal cells derived from human skin
    • Huang HI, Chen SK, Ling QD, Chien CC, Liu HT, Chan SH. Multilineage differentiation potential of fibroblast-like stromal cells derived from human skin. Tissue Eng Part A. 2010;16(5):1491–1501.
    • (2010) Tissue Eng Part A , vol.16 , Issue.5 , pp. 1491-1501
    • Huang, H.I.1    Chen, S.K.2    Ling, Q.D.3    Chien, C.C.4    Liu, H.T.5    Chan, S.H.6
  • 122
    • 84888433518 scopus 로고    scopus 로고
    • Human foreskin fibroblast-like stromal cells can differentiate into functional hepatocytic cells
    • Huang HI, Chen SK, Wang RYL, Shen CR, Cheng YC. Human foreskin fibroblast-like stromal cells can differentiate into functional hepatocytic cells. Cell Biol Int. 2013;37(12):1308–1319.
    • (2013) Cell Biol Int , vol.37 , Issue.12 , pp. 1308-1319
    • Huang, H.I.1    Chen, S.K.2    Wang, R.3    Shen, C.R.4    Cheng, Y.C.5
  • 123
    • 7944237574 scopus 로고    scopus 로고
    • A dermal niche for multipotent adult skin-derived precursor cells
    • Fernandes KJ, McKenzie IA, Mill P. A dermal niche for multipotent adult skin-derived precursor cells. Nat Cell Biol. 2004;6(11):1082–1093.
    • (2004) Nat Cell Biol , vol.6 , Issue.11 , pp. 1082-1093
    • Fernandes, K.J.1    McKenzie, I.A.2    Mill, P.3
  • 125
    • 0034848122 scopus 로고    scopus 로고
    • Isolation of multipotent adult stem cells from the dermis of mammalian skin
    • Toma JG, Akhavan M, Fernandes KJ, et al. Isolation of multipotent adult stem cells from the dermis of mammalian skin. Nat Cell Biol. 2001;3(9):778–784.
    • (2001) Nat Cell Biol , vol.3 , Issue.9 , pp. 778-784
    • Toma, J.G.1    Akhavan, M.2    Fernandes, K.J.3
  • 126
    • 70350714215 scopus 로고    scopus 로고
    • Characterization and hepatic differentiation of skin-derived precursors from adult foreskin by sequential exposure to hepatogenic cytokines and growth factors reflecting liver development
    • De Kock J, Vanhaecke T, Biernaskie J, Rogiers V, Snykers S. Characterization and hepatic differentiation of skin-derived precursors from adult foreskin by sequential exposure to hepatogenic cytokines and growth factors reflecting liver development. Toxicol In Vitro. 2009;23(8):1522–1527.
    • (2009) Toxicol in Vitro , vol.23 , Issue.8 , pp. 1522-1527
    • De Kock, J.1    Vanhaecke, T.2    Biernaskie, J.3    Rogiers, V.4    Snykers, S.5
  • 127
    • 36348966529 scopus 로고    scopus 로고
    • Human skin fibroblasts: From mesodermal to hepatocyte-like differentiation
    • Lysy PA, Smets F, Sibille C, et al. Human skin fibroblasts: from mesodermal to hepatocyte-like differentiation. Hepatology. 2007;46(5):1574–1585.
    • (2007) Hepatology , vol.46 , Issue.5 , pp. 1574-1585
    • Lysy, P.A.1    Smets, F.2    Sibille, C.3
  • 128
    • 0025912865 scopus 로고
    • Permanent engraftment and function of hepatocytes delivered to the liver: Implications for gene therapy and liver repopulation
    • Gupta S, Aragona E, Vemuru RP, Bhargava KK, Burk RD, Chowdhury JR. Permanent engraftment and function of hepatocytes delivered to the liver: implications for gene therapy and liver repopulation. Hepatology. 1991;14(1):144–149.
    • (1991) Hepatology , vol.14 , Issue.1 , pp. 144-149
    • Gupta, S.1    Aragona, E.2    Vemuru, R.P.3    Bhargava, K.K.4    Burk, R.D.5    Chowdhury, J.R.6
  • 129
    • 0032950292 scopus 로고    scopus 로고
    • Mechanisms of cell engraftment during liver repopulation with hepatocyte transplantation
    • Gupta S, Bhargava KK, Novikoff PM. Mechanisms of cell engraftment during liver repopulation with hepatocyte transplantation. Semin Liver Dis. 1999;19(1):15–26.
    • (1999) Semin Liver Dis , vol.19 , Issue.1 , pp. 15-26
    • Gupta, S.1    Bhargava, K.K.2    Novikoff, P.M.3
  • 131
    • 0344142526 scopus 로고    scopus 로고
    • Hepatocyte transplantation for the treatment of human disease
    • Strom SC, Chowdhury JR, Fox IJ. Hepatocyte transplantation for the treatment of human disease. Semin Liver Dis. 1999;19(1):39–48.
    • (1999) Semin Liver Dis , vol.19 , Issue.1 , pp. 39-48
    • Strom, S.C.1    Chowdhury, J.R.2    Fox, I.J.3
  • 132
    • 0037978092 scopus 로고    scopus 로고
    • Isolated hepatocyte transplantation in an infant with a severe urea cycle disorder
    • Horslen SP, McCowan TC, Goertzen TC, et al. Isolated hepatocyte transplantation in an infant with a severe urea cycle disorder. Pediatrics. 2003;111(6 pt 1):1262–1267.
    • (2003) Pediatrics , vol.111 , Issue.6 , pp. 1262-1267
    • Horslen, S.P.1    McCowan, T.C.2    Goertzen, T.C.3
  • 134
    • 77952091621 scopus 로고    scopus 로고
    • Human hepatocyte transplantation: Current experience and future challenges
    • Dhawan A, Puppi J, Hughes RD, Mitry RR. Human hepatocyte transplantation: current experience and future challenges. Nat Rev Gastroenterol Hepatol. 2010;7(5):288–298.
    • (2010) Nat Rev Gastroenterol Hepatol , vol.7 , Issue.5 , pp. 288-298
    • Dhawan, A.1    Puppi, J.2    Hughes, R.D.3    Mitry, R.R.4
  • 135
    • 84930407913 scopus 로고    scopus 로고
    • Cell sources, liver support systems and liver tissue engineering: Alternatives to liver transplantation
    • Lee SY, Kim HJ, Choi D. Cell sources, liver support systems and liver tissue engineering: alternatives to liver transplantation. Int J Stem Cells. 2015;8(1):36–47.
    • (2015) Int J Stem Cells , vol.8 , Issue.1 , pp. 36-47
    • Lee, S.Y.1    Kim, H.J.2    Choi, D.3
  • 136
    • 33846350570 scopus 로고    scopus 로고
    • Hog heaven on the road to liver cell therapy
    • Gupta S. Hog heaven on the road to liver cell therapy. Gastroenterology. 2007;132(1):450–453.
    • (2007) Gastroenterology , vol.132 , Issue.1 , pp. 450-453
    • Gupta, S.1
  • 137
    • 33846256265 scopus 로고    scopus 로고
    • Prolonged survival of porcine hepatocytes in cynomolgus monkeys
    • Nagata H, Nishitai R, Shirota C, et al. Prolonged survival of porcine hepatocytes in cynomolgus monkeys. Gastroenterology. 2007;132(1):321–329.
    • (2007) Gastroenterology , vol.132 , Issue.1 , pp. 321-329
    • Nagata, H.1    Nishitai, R.2    Shirota, C.3
  • 138
    • 84939216194 scopus 로고    scopus 로고
    • Hybrid periportal hepatocytes regenerate the injured liver without giving rise to cancer
    • Font-Burgada J, Shalapour S, Ramaswamy S, et al. Hybrid periportal hepatocytes regenerate the injured liver without giving rise to cancer. Cell. 2015;162(4):766–779.
    • (2015) Cell , vol.162 , Issue.4 , pp. 766-779
    • Font-Burgada, J.1    Shalapour, S.2    Ramaswamy, S.3
  • 139
    • 84904469260 scopus 로고    scopus 로고
    • Cellular transplantation for liver diseases
    • Jameson E. Cellular transplantation for liver diseases. Gastroen Res. 2008;1(1):8–13.
    • (2008) Gastroen Res , vol.1 , Issue.1 , pp. 8-13
    • Jameson, E.1
  • 140
    • 84923477365 scopus 로고    scopus 로고
    • The multiple functional roles of mesenchymal stem cells in participating in treating liver diseases
    • Liu WH, Song FQ, Ren LN, et al. The multiple functional roles of mesenchymal stem cells in participating in treating liver diseases. J Cell Mol Med. 2015;19(3):511–520.
    • (2015) J Cell Mol Med , vol.19 , Issue.3 , pp. 511-520
    • Liu, W.H.1    Song, F.Q.2    Ren, L.N.3
  • 141
    • 84926471980 scopus 로고    scopus 로고
    • REpeated AutoLogous Infusions of STem cells In Cirrhosis (REALISTIC): A multicentre, phase II, open-label, randomised controlled trial of repeated autologous infusions of granulocyte colony-stimulating factor (GCSF) mobilised CD133+ bone marrow stem cells in patients with cirrhosis. A study protocol for a randomised controlled trial
    • King A, Barton D, Beard HA, et al. REpeated AutoLogous Infusions of STem cells In Cirrhosis (REALISTIC): a multicentre, phase II, open-label, randomised controlled trial of repeated autologous infusions of granulocyte colony-stimulating factor (GCSF) mobilised CD133+ bone marrow stem cells in patients with cirrhosis. A study protocol for a randomised controlled trial. BMJ Open. 2015;5(3):e007700.
    • (2015) BMJ Open , vol.5 , Issue.3
    • King, A.1    Barton, D.2    Beard, H.A.3
  • 142
    • 84926337245 scopus 로고    scopus 로고
    • Transplantation of autologous mesenchymal stem cells for end-stage liver cirrhosis: A meta-analysis based on seven controlled trials
    • Ma XR, Tang YL, Xuan M, Chang Z, Wang XY, Liang XH. Transplantation of autologous mesenchymal stem cells for end-stage liver cirrhosis: a meta-analysis based on seven controlled trials. Gastroenterol Res Pract. 2015;2015:908275.
    • (2015) Gastroenterol Res Pract , vol.2015
    • Ma, X.R.1    Tang, Y.L.2    Xuan, M.3    Chang, Z.4    Wang, X.Y.5    Liang, X.H.6
  • 143
    • 84933533553 scopus 로고    scopus 로고
    • The impact of repeated autologous infusion of haematopoietic stem cells in patients with liver insufficiency
    • Zekri AR, Salama H, Medhat E, et al. The impact of repeated autologous infusion of haematopoietic stem cells in patients with liver insufficiency. Stem Cell Res Ther. 2015;6:118.
    • (2015) Stem Cell Res Ther , vol.6
    • Zekri, A.R.1    Salama, H.2    Medhat, E.3
  • 144
    • 84855954616 scopus 로고    scopus 로고
    • New horizons for stem cell therapy in liver disease
    • Forbes SJ, Newsome PN. New horizons for stem cell therapy in liver disease. J Hepatol. 2012;56(2):496–499.
    • (2012) J Hepatol , vol.56 , Issue.2 , pp. 496-499
    • Forbes, S.J.1    Newsome, P.N.2
  • 145
    • 79951775415 scopus 로고    scopus 로고
    • An overview of tissue and whole organ decellularization processes
    • Crapo PM, Gilbert TW, Badylak SF. An overview of tissue and whole organ decellularization processes. Biomaterials. 2011;32(12):3233–3243.
    • (2011) Biomaterials , vol.32 , Issue.12 , pp. 3233-3243
    • Crapo, P.M.1    Gilbert, T.W.2    Badylak, S.F.3
  • 146
    • 77954533642 scopus 로고    scopus 로고
    • Organ reengineering through development of a transplantable recellularized liver graft using decellularized liver matrix
    • Uygun BE, Soto-Gutierrez A, Yagi H, et al. Organ reengineering through development of a transplantable recellularized liver graft using decellularized liver matrix. Nat Med. 2010;16(7):814–820.
    • (2010) Nat Med , vol.16 , Issue.7 , pp. 814-820
    • Uygun, B.E.1    Soto-Gutierrez, A.2    Yagi, H.3
  • 147
    • 79958288464 scopus 로고    scopus 로고
    • Whole-organ regenerative medicine approach for liver replacement
    • Soto-Gutierrez A, Zhang L, Medberry C, et al. Whole-organ regenerative medicine approach for liver replacement. Tissue Eng Part C Methods. 2011;17(6):677–686.
    • (2011) Tissue Eng Part C Methods , vol.17 , Issue.6 , pp. 677-686
    • Soto-Gutierrez, A.1    Zhang, L.2    Medberry, C.3
  • 148
    • 79251521794 scopus 로고    scopus 로고
    • The use of whole organ decellularization for the generation of a vascularized liver organoid
    • Baptista PM, Siddiqui MM, Lozier G, Rodriguez SR, Atala A, Soker S. The use of whole organ decellularization for the generation of a vascularized liver organoid. Hepatology. 2011;53(2):604–617.
    • (2011) Hepatology , vol.53 , Issue.2 , pp. 604-617
    • Baptista, P.M.1    Siddiqui, M.M.2    Lozier, G.3    Rodriguez, S.R.4    Atala, A.5    Soker, S.6
  • 149
    • 84857036993 scopus 로고    scopus 로고
    • Use of decellularized porcine liver for engineering humanized liver organ
    • Barakat O, Abbasi S, Rodriguez G, et al. Use of decellularized porcine liver for engineering humanized liver organ. J Surg Res. 2012;173(1):e11–e25.
    • (2012) J Surg Res , vol.173 , Issue.1 , pp. e11-e25
    • Barakat, O.1    Abbasi, S.2    Rodriguez, G.3
  • 150
    • 79953002875 scopus 로고    scopus 로고
    • Biofabrication of a three-dimensional liver micro-organ as an in vitro drug metabolism model
    • Chang R, Emami K, Wu H, Sun W. Biofabrication of a three-dimensional liver micro-organ as an in vitro drug metabolism model. Biofabrication. 2010;2(4):045004.
    • (2010) Biofabrication. , vol.2 , Issue.4
    • Chang, R.1    Emami, K.2    Wu, H.3    Sun, W.4
  • 151
    • 85027934971 scopus 로고    scopus 로고
    • Transplantation: 3D printing of the liver in living donor liver transplantation
    • Ikegami T, Maehara Y. Transplantation: 3D printing of the liver in living donor liver transplantation. Nat Rev Gastroenterol Hepatol. 2013;10(12):697–698.
    • (2013) Nat Rev Gastroenterol Hepatol , vol.10 , Issue.12 , pp. 697-698
    • Ikegami, T.1    Maehara, Y.2
  • 152
    • 84902097724 scopus 로고    scopus 로고
    • Micropatterned cell–cell interactions enable functional encapsulation of primary hepatocytes in hydrogel microtissues
    • Li CY, Stevens KR, Schwartz RE, Alejandro BS, Huang JH, Bhatia SN. Micropatterned cell–cell interactions enable functional encapsulation of primary hepatocytes in hydrogel microtissues. Tissue Eng Part A. 2014;20(15–16):2200–2212.
    • (2014) Tissue Eng Part A , vol.20 , Issue.15-16 , pp. 2200-2212
    • Li, C.Y.1    Stevens, K.R.2    Schwartz, R.E.3    Alejandro, B.S.4    Huang, J.H.5    Bhatia, S.N.6
  • 153
    • 84934293712 scopus 로고    scopus 로고
    • Bio-pick, place, and perfuse: A new instrument for three-dimensional tissue engineering
    • Blakely AM, Manning KL, Tripathi A, Morgan JR. Bio-pick, place, and perfuse: A new instrument for three-dimensional tissue engineering. Tissue Eng Part C Methods. 2015;21(7):737–746.
    • (2015) Tissue Eng Part C Methods , vol.21 , Issue.7 , pp. 737-746
    • Blakely, A.M.1    Manning, K.L.2    Tripathi, A.3    Morgan, J.R.4
  • 155
    • 84864595250 scopus 로고    scopus 로고
    • Generating an iPSC bank for HLA-matched tissue transplantation based on known donor and recipient HLA types
    • Taylor CJ, Peacock S, Chaudhry AN, Bradley JA, Bolton EM. Generating an iPSC bank for HLA-matched tissue transplantation based on known donor and recipient HLA types. Cell Stem Cell. 2012;11(2):147–152.
    • (2012) Cell Stem Cell , vol.11 , Issue.2 , pp. 147-152
    • Taylor, C.J.1    Peacock, S.2    Chaudhry, A.N.3    Bradley, J.A.4    Bolton, E.M.5
  • 156
    • 84885101524 scopus 로고    scopus 로고
    • Toward the development of a global induced pluripotent stem cell library
    • Turner M, Leslie S, Martin NG, et al. Toward the development of a global induced pluripotent stem cell library. Cell Stem Cell. 2013;13(4):382–384.
    • (2013) Cell Stem Cell , vol.13 , Issue.4 , pp. 382-384
    • Turner, M.1    Leslie, S.2    Martin, N.G.3
  • 157
    • 85050578973 scopus 로고    scopus 로고
    • Current research in aging: A report from the 2015 Ageing Summit
    • Moyse E, Lahousse L, Krantic S. Current research in aging: a report from the 2015 Ageing Summit. Neurodegen Dis Manag. 2015;5(3):187–190.
    • (2015) Neurodegen Dis Manag , vol.5 , Issue.3 , pp. 187-190
    • Moyse, E.1    Lahousse, L.2    Krantic, S.3
  • 158
    • 84874467038 scopus 로고    scopus 로고
    • Understanding the aging process using epidemiologic approaches
    • In: Newman AB, Cauley JA, editors, Dordrecht/Heidelberg/New York: Springer
    • Sanders J, Boudreau R, Newman A. Understanding the aging process using epidemiologic approaches. In: Newman AB, Cauley JA, editors. The Epidemiology of Aging. Dordrecht/Heidelberg/New York: Springer; 2012:187–214.
    • (2012) The Epidemiology of Aging , pp. 187-214
    • Sanders, J.1    Boudreau, R.2    Newman, A.3
  • 159
    • 84886111619 scopus 로고    scopus 로고
    • DNA methylation age of human tissues and cell types
    • Horvath S. DNA methylation age of human tissues and cell types. Genome Biol. 2013;14:R115.
    • (2013) Genome Biol , vol.14
    • Horvath, S.1
  • 160
    • 84908441328 scopus 로고    scopus 로고
    • Obesity accelerates epigenetic aging of human liver
    • Horvath S, Erhart W, Brosch M, et al. Obesity accelerates epigenetic aging of human liver. Proc Natl Acad Sci U S A. 2014;111(43):15538–15543.
    • (2014) Proc Natl Acad Sci U S A , vol.111 , Issue.43 , pp. 15538-15543
    • Horvath, S.1    Erhart, W.2    Brosch, M.3
  • 161
    • 38449115224 scopus 로고    scopus 로고
    • On the evolution of anti-aging medicine
    • Walker RF. On the evolution of anti-aging medicine. Clin Int Aging. 2006;1(3):201–203.
    • (2006) Clin Int Aging , vol.1 , Issue.3 , pp. 201-203
    • Walker, R.F.1
  • 162
    • 84893748014 scopus 로고    scopus 로고
    • Characterization of human induced pluripotent stem cell-derived retinal pigment epithelium cell sheets aiming for clinical application
    • Kamao H, Mandai M, Okamoto S, et al. Characterization of human induced pluripotent stem cell-derived retinal pigment epithelium cell sheets aiming for clinical application. Stem Cell Reports. 2014;2(2):205–218.
    • (2014) Stem Cell Reports , vol.2 , Issue.2 , pp. 205-218
    • Kamao, H.1    Mandai, M.2    Okamoto, S.3
  • 163
    • 84907752479 scopus 로고    scopus 로고
    • Japan stem-cell trial stirs envy
    • Riardon S, Cyranoski D. Japan stem-cell trial stirs envy. Nature. 2014;513(7518):287–288.
    • (2014) Nature , vol.513 , Issue.7518 , pp. 287-288
    • Riardon, S.1    Cyranoski, D.2
  • 164
    • 84930652559 scopus 로고    scopus 로고
    • Current bioengineering methods for whole kidney regeneration
    • Yamanaka S, Yokoo T. Current bioengineering methods for whole kidney regeneration. Stem Cells Int. 2015;2015:724047.
    • (2015) Stem Cells Int , vol.2015
    • Yamanaka, S.1    Yokoo, T.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.