Mitochondrial-Associated cell death mechanisms are reset to an Embryonic-Like state in aged Donor-Derived iPS cells harboring chromosomal aberrations

PLoS ONE

Volumn 6, Issue 11, 2011, Pages

  Prigione, Alessandro ^a   Hossini, Amir M ^b   Lichtner, Björn ^a   Serin, Akdes ^a   Fauler, Beatrix ^a   Megges, Matthias ^a   Lurz, Rudi ^a   Lehrach, Hans ^a   Makrantonaki, Eugenia ^b,c   Zouboulis, Christos C ^b   Adjaye, James ^a,d  

^a MAX PLANCK INSTITUTE FOR MOLECULAR GENETICS   (Germany)

^b DESSAU MEDICAL CENTER   (Germany)

^c CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^d KING SAUD UNIVERSITY   (Saudi Arabia)

Author keywords

[No Author keywords available]

Indexed keywords

TELOMERASE;

AGED; APOPTOSIS; ARTICLE; CELL AGING; CELL FUNCTION; CELL ULTRASTRUCTURE; CHROMOSOME ABERRATION; CONTROLLED STUDY; DNA DAMAGE; EMBRYO; EMBRYO CELL; ENZYME ACTIVITY; FEMALE; HUMAN; HUMAN CELL; KARYOTYPING; MALE; MALIGNANT TRANSFORMATION; MITOCHONDRIAL MEMBRANE; NERVE CELL DIFFERENTIATION; NEWBORN; OXIDATIVE STRESS; PLURIPOTENT STEM CELL; SKIN FIBROBLAST; SOMATIC CELL; AGING; CELL DEATH; CYTOLOGY; DONOR; FIBROBLAST; GENETICS; GENOMIC INSTABILITY; KARYOTYPE; METABOLISM; MITOCHONDRION; NUCLEAR REPROGRAMMING; PATHOLOGY; SIGNAL TRANSDUCTION;

IPS;

AGED, 80 AND OVER; AGING; CELL DEATH; CHROMOSOME ABERRATIONS; FEMALE; FIBROBLASTS; GENOMIC INSTABILITY; HUMANS; INDUCED PLURIPOTENT STEM CELLS; KARYOTYPE; MITOCHONDRIA; NUCLEAR REPROGRAMMING; OXIDATIVE STRESS; SIGNAL TRANSDUCTION; TISSUE DONORS;

EID: 81055124788     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0027352     Document Type: Article

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