TGFβ/activin/nodal signaling is necessary for the maintenance of pluripotency in human embryonic stem cells

Development

Volumn 132, Issue 6, 2005, Pages 1273-1282

  James, Daylon ^a   Levine, Ariel J ^a   Besser, Daniel ^a   Hemmati Brivanlou, Ali ^a  

^a ROCKEFELLER UNIVERSITY   (United States)

Author keywords

Human embryonic stem cells (hESCs); SMAD2 3; TGF signaling

Indexed keywords

ACTIVIN; ACTIVIN A; BONE MORPHOGENETIC PROTEIN; PROTEIN NODAL; SMAD1 PROTEIN; SMAD2 PROTEIN; SMAD3 PROTEIN; SMAD5 PROTEIN; TRANSFORMING GROWTH FACTOR BETA; WNT PROTEIN; 1,3 DIOXOLANE DERIVATIVE; 4 (5 BENZO(1,3)DIOXOL 5 YL 4 PYRIDIN 2 YL 1H IMIDAZOL 2 YL)BENZAMIDE; 4-(5-BENZO(1,3)DIOXOL-5-YL-4-PYRIDIN-2-YL-1H-IMIDAZOL-2-YL)BENZAMIDE; BENZAMIDE DERIVATIVE; DNA BINDING PROTEIN; PHOSPHOPROTEIN; PROTEIN SERINE THREONINE KINASE; SMAD2 PROTEIN, HUMAN; SMAD2 PROTEIN, MOUSE; SMAD3 PROTEIN, HUMAN; SMAD3 PROTEIN, MOUSE; SMAD5 PROTEIN, HUMAN; SMAD5 PROTEIN, MOUSE; TGF BETA RECEPTOR PROTEIN KINASE; TGF-BETA RECEPTOR PROTEIN KINASE; TRANSACTIVATOR PROTEIN;

ANIMAL CELL; ARTICLE; BLASTOCYST; CELL DIFFERENTIATION; CELL FUNCTION; CELL ISOLATION; CELL SYNCHRONIZATION; EMBRYO; EMBRYO DEVELOPMENT; EMBRYONIC STEM CELL; EX VIVO STUDY; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; HUMAN EMBRYO; MOUSE; NONHUMAN; PLURIPOTENT STEM CELL; PRIORITY JOURNAL; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; ANIMAL; DRUG ANTAGONISM; DRUG EFFECT; METABOLISM; PHYSIOLOGY;

ANIMALIA;

ACTIVINS; ANIMALS; BENZAMIDES; BLASTOCYST; DIOXOLES; DNA-BINDING PROTEINS; HUMANS; MICE; PHOSPHOPROTEINS; PLURIPOTENT STEM CELLS; PROTEIN-SERINE-THREONINE KINASES; SIGNAL TRANSDUCTION; SMAD2 PROTEIN; SMAD3 PROTEIN; SMAD5 PROTEIN; TRANS-ACTIVATORS; TRANSFORMING GROWTH FACTOR BETA;

EID: 16244400050     PISSN: 09501991     EISSN: None     Source Type: Journal    
DOI: 10.1242/dev.01706     Document Type: Article

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