A whole-organ regenerative medicine approach for liver replacement

Tissue Engineering - Part C: Methods

Volumn 17, Issue 6, 2011, Pages 677-686

  Soto Gutierrez, Alejandro ^a,b   Zhang, Li ^b,c   Medberry, Chris ^b,c   Fukumitsu, Ken ^a,b   Faulk, Denver ^b,c   Jiang, Hongbin ^b,c   Reing, Janet ^b,c   Gramignoli, Roberto ^d   Komori, Junji ^b,d   Ross, Mark ^d   Nagaya, Masaki ^a,b   Lagasse, Eric ^b,d   Stolz, Donna ^d   Strom, Stephen C ^d   Fox, Ira J ^a,b   Badylak, Stephen F ^b,c,e  

^a CHILDREN S HOSPITAL OF PITTSBURGH   (United States)

^b UNIVERSITY OF PITTSBURGH   (United States)

^c Department of Bioengineering ^*  (United States)

^d UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^e UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; DIRECT INJECTION; DISEASE CONTROL; DRAINAGE; METABOLISM; THREE DIMENSIONAL; TISSUE; UREA;

CELL SURVIVAL; CELL-BASED THERAPY; CYTOCHROME P450; DECELLULARIZATION; DECELLULARIZED; DRAINAGE SYSTEMS; ENGRAFTMENT; EXTRACELLULAR MATRIX COMPONENTS; FUNCTIONAL CAPACITY; GROWTH FACTOR; HEPATIC TISSUE ENGINEERING; HEPATOCYTES; IMMUNOLABELING; LIVER DISEASE; LIVER TISSUE; LIVER TRANSPLANTATION; MACROSTRUCTURES; MATRIX; MATRIX ARCHITECTURE; MECHANICAL METHODS; MICROVASCULAR NETWORK; MULTI-STEP; RAT LIVERS; REGENERATIVE MEDICINE;

SCAFFOLDS (BIOLOGY);

RATTUS;

TISSUE SCAFFOLD;

ANIMAL; ARTICLE; ARTIFICIAL LIVER; C57BL MOUSE; CELL CULTURE; CELL DIFFERENTIATION; CYTOLOGY; LIVER CELL; MALE; METHODOLOGY; MOUSE; ORGAN CULTURE TECHNIQUE; PHYSIOLOGY; PROSTHESIS; RAT; SPRAGUE DAWLEY RAT; TRANSPLANTATION;

ANIMALS; CELL DIFFERENTIATION; CELLS, CULTURED; HEPATOCYTES; LIVER, ARTIFICIAL; MALE; MICE; MICE, INBRED C57BL; ORGAN CULTURE TECHNIQUES; PROSTHESIS DESIGN; RATS; RATS, SPRAGUE-DAWLEY; TISSUE SCAFFOLDS;

EID: 79958288464     PISSN: 19373384     EISSN: 19373392     Source Type: Journal    
DOI: 10.1089/ten.tec.2010.0698     Document Type: Article

References (30)

1. Klein, A.S., Messersmith, E.E., Ratner, L.E., Kochik, R., Baliga, P.K., and Ojo, A.O. Organ donation and utilization in the United States, 1999-2008. Am J Transplant 10, 973, 2010.
2. Soltys, K.A., Soto-Gutierrez, A., Nagaya, M., Baskin, K.M., Deutsch, M., Ito, R., ShneiDer, B.L., Squires, R., Vockley, J., Guha, C., Roy-Chowdhury, J., Strom, S.C., Platt, J.L., and Fox, I.J. Barriers to the successful treatment of liver disease by hepatocyte transplantation. J Hepatol 53, 769, 2010.
3. Kidambi, S., Yarmush, R.S., Novik, E., Chao, P., Yarmush, M.L., and Nahmias, Y. Oxygen-mediated enhancement of primary hepatocyte metabolism, functional polarization, gene expression, and drug clearance. Proc Natl Acad Sci USA 106, 15714, 2009.
4. Uygun, B.E., Soto-Gutierrez, A., Yagi, H., Izamis, M.L., Guzzardi, M.A., Shulman, C., Milwid, J., Kobayashi, N., Tilles, A., Berthiaume, F., Hertl, M., Nahmias, Y., Yarmush, M.L., and Uygun, K. Organ reengineering through Development of a transplantable recellularized liver graft using Decellularized liver matrix. Nat Med 16, 814, 2010.
5. Petersen, T.H., Calle, E.A., Zhao, L., Lee, E.J., Gui, L., Raredon, M.B., Gavrilov, K., Yi, T., Zhuang, Z.W., Breuer, C., Herzog, E., and Niklason, L.E. Tissue-engineered lungs for in vivo implantation. Science 329, 538, 2010.
6. Ott, H.C., Clippinger, B., Conrad, C., Schuetz, C., Pomerantseva, I., Ikonomou, L., Kotton, D., and Vacanti, J.P. Regeneration and orthotopic transplantation of a bioartificial lung. Nat Med 16, 927, 2010.
7. Ott, H.C., Matthiesen, T.S., Goh, S.K., Black, L.D., Kren, S.M., Netoff, T.I., and Taylor, D.A. Perfusion-Decellularized matrix: using nature's platform to engineer a bioartificial heart. Nat Med 14, 213, 2008.
8. Wainwright, J.M., Czajka, C.A., Patel, U.B., Freytes, D.O., Tobita, K., Gilbert, T.W., and Badylak, S.F. Preparation of cardiac extracellular matrix from an intact porcine heart. Tissue Eng Part C Methods 16, 525, 2010.
9. Badylak, S.F., Freytes, D.O., and Gilbert, T.W. Extracellular matrix as a biological scaffold material: structure and function. Acta Biomater 5, 1, 2009.
10. Vracko, R. Basal lamina scaffold-anatomy and significance for maintenance of orDerly tissue structure. Am J Pathol 77, 314, 1974.
11. Sellaro, T.L., RanaDe, A., Faulk, D.M., McCabe, G.P., Dorko, K., Badylak, S.F., and Strom, S.C. Maintenance of human hepatocyte function in vitro by liver-Derived extracellular matrix gels. Tissue Eng Part A 16, 1075, 2010.
12. Sellaro, T.L., Ravindra, A.K., Stolz, D.B., and Badylak, S.F. Maintenance of hepatic sinusoidal endothelial cell phenotype in vitro using organ-specific extracellular matrix scaffolds. Tissue Eng 13, 2301, 2007.
13. Cortiella, J., Niles, J., Cantu, A., Brettler, A., Pham, A., Vargas, G., Winston, S., Wang, J., Walls, S., and Nichols, J.E. Influence of acellular natural lung matrix on murine embryonic stem cell differentiation and tissue formation. Tissue Eng Part A 16, 2565, 2010.
14. Soto-Gutierrez, A., Navarro-Alvarez, N., Rivas-Carrillo, J.D., Tanaka, K., Chen, Y., Misawa, H., Okitsu, T., Noguchi, H., Tanaka, N., and Kobayashi, N. Construction and transplantation of an engineered hepatic tissue using a polyaminourethane- coated nonwoven polytetrafluoroethylene fabric. Transplantation 83, 129, 2007.
15. Crapo, P.M., Gilbert, T.W., and Badylak, S.F. An overview of tissue and whole organ Decellularization processes. Biomaterials 32, 3233, 2011.
16. Torii, T., Miyazawa, M., and Koyama, I. Effect of continuous application of shear stress on liver tissue: continuous application of appropriate shear stress has advantage in protection of liver tissue. Transplant Proc 37, 4575, 2005.
17. Tilles, A.W., Baskaran, H., Roy, P., Yarmush, M.L., and Toner, M. Effects of oxygenation and flow on the viability and function of rat hepatocytes cocultured in a microchannel flat-plate bioreactor. Biotechnol Bioeng 73, 379, 2001.
18. Straub, A.C., Clark, K.A., Ross, M.A., Chandra, A.G., Li, S., Gao, X., Pagano, P.J., Stolz, D.B., and Barchowsky, A. Arsenic-stimulated liver sinusoidal capillarization in mice requires NADPH oxidase-generated superoxiDe. J Clin Invest 118, 3980, 2008.
19. Gilbert, T.W., Freund, J.M., and Badylak, S.F. Quantification of DNA in biologic scaffold materials. J Surg Res 152, 135, 2009.
20. Wen, Y.H., Sahi, J., Urda, E., Kulkarni, S., Rose, K., Zheng, X., Sinclair, J.F., Cai, H., Strom, S.C., and Kostrubsky, V.E. Effects of bergamottin on human and monkey drugmetabolizing enzymes in primary cultured hepatocytes. Drug Metab Dispos 30, 977, 2002.
21. Yarmush,M.L., Dunn, J.C., and Tompkins, R.G. Assessment of artificial liver support technology. Cell Transplant 1, 323, 1992.
22. Navarro-Alvarez, N., Soto-Gutierrez, A., Chen, Y., Caballero-Corbalan, J., Hassan, W., Kobayashi, S., Kondo, Y., Iwamuro, M., Yamamoto, K., Kondo, E., Tanaka, N., Fox, I.J., and Kobayashi, N. Intramuscular transplantation of engineered hepatic tissue constructs corrects acute and chronic liver failure in mice. J Hepatol 52, 211, 2010.
23. Soto-Gutierrez, A., Navarro-Alvarez, N., Yagi, H., Nahmias, Y., Yarmush, M.L., and Kobayashi, N. Engineering of an hepatic organoid to Develop liver assist Devices. Cell Transplant 19, 815, 2010.
24. Shupe, T., Williams, M., Brown, A., Willenberg, B., and Petersen, B.E. Method for the Decellularization of intact rat liver. Organogenesis 6, 134, 2010.
25. Stamatoglou, S.C., Enrich, C., Manson, M.M., and Hughes, R.C. Temporal changes in the expression and distribution of adhesion molecules during liver Development and regeneration. J Cell Biol 116, 1507, 1992.
26. Pekkari, K., and Holmgren, A. Truncated thioredoxin: physiological functions and mechanism. Antioxid Redox Signal 6, 53, 2004.
27. Agrawal, V., Johnson, S.A., Reing, J., Zhang, L., Tottey, S., Wang, G., Hirschi, K.K., Braunhut, S., Gudas, L.J., and Badylak, S.F. Epimorphic regeneration approach to tissue replacement in adult mammals. Proc Natl Acad Sci USA 107, 3351, 2010.
28. Soto-Gutierrez, A., Yagi, H., Uygun, B.E., Navarro-Alvarez, N., Uygun, K., Kobayashi, N., Yang, Y.G., and Yarmush, M.L. Cell Delivery: from cell transplantation to organ engineering. Cell Transplant 19, 655, 2010.
29. Basma, H., Soto-Gutierrez, A., Yannam, G.R., Liu, L., Ito, R., Yamamoto, T., Ellis, E., Carson, S.D., Sato, S., Chen, Y., Muirhead, D., Navarro-Alvarez, N., Wong, R.J., Roy- Chowdhury, J., Platt, J.L., Mercer, D.F., Miller, J.D., Strom, S.C., Kobayashi, N., and Fox, I.J. Differentiation and transplantation of human embryonic stem cell-Derived hepatocytes. Gastroenterology 136, 990, 2009.
30. Soto-Gutierrez, A., Kobayashi, N., Rivas-Carrillo, J.D., Navarro-Alvarez, N., Zhao, D., Okitsu, T., Noguchi, H., Basma, H., Tabata, Y., Chen, Y., Tanaka, K., Narushima, M., Miki, A., Ueda, T., Jun, H.S., Yoon, J.W., Lebkowski, J., Tanaka, N., and Fox, I.J. Reversal of mouse hepatic failure using an implanted liver-assist Device containing ES cellDerived hepatocytes. Nat Biotechnol 24, 1412, 2006.