Retroviral gene transfer of signaling molecules into murine fetal hepatocytes defines distinct roles for the STAT3 and ras pathways during hepatic development

Hepatology

Volumn 32, Issue 6, 2000, Pages 1370-1376

  Ito, Yoshiaki ^a,b   Matsui, Takaaki ^a   Kamiya, Akihide ^a,c   Kinoshita, Taisei ^a   Miyajima, Atsushi ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b IWATE UNIVERSITY   (Japan)

^c TEIKYO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ONCOSTATIN M; RAS PROTEIN; STAT3 PROTEIN; STAT5 PROTEIN;

ANIMAL TISSUE; ARTICLE; FETUS; GENE ACTIVATION; GENE EXPRESSION; GENE FUNCTION; GENE TRANSFER; LIVER CELL CULTURE; LIVER DEVELOPMENT; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RETROVIRUS;

EID: 0033658759     PISSN: 02709139     EISSN: None     Source Type: Journal    
DOI: 10.1053/jhep.2000.19815     Document Type: Article

References (40)

1. Hepatic specification of the gut endoderm in vitro: Cell signaling and transcriptional control
2. Definitive hematopoiesis is autonomously initiated by the AGM region
3. In vitro expansion of routine multipotential hematopoietic progenitors from the embryonic aorta-gonad-mesonephros region
4. Developmental control of gene expression of tryptophan 2,3-dioxygenase in neonatal rat liver
5. Developmental regulation of rat serine dehydratase gene expression: Evidence for the presence of a repressor in fetal hepatocytes
6. Hepatic differentiation induced by oncostatin M attenuates fetal liver hematopoiesis
7. Fetal liver development requires a paracrine action of oncostatin M through the gp130 signal transducer
8. Mouse oncostatin M: An immediate early gene induced by multiple cytokines through the JAK-STAT5 pathway
9. Cloning and characterization of a specific receptor for mouse oncostatin M
10. Functional reconstitution of the mouse oncostatin M receptor: Molecular cloning of the mouse OSM receptor b subunit
11. Signaling mechanisms through gp130: A model of the cytokine system
12. Gp130 and the interleukin-6 family of cytokines
13. Two signals are necessary for cell proliferation induced by a cytokine receptor gp130: Involvement of STAT3 in anti-apoptosis
14. Choice of STATs and other substrates specified by modular tyrosine-based motifs in cytokine receptors
15. Differentiation and growth arrest signals are generated through the cytoplasmic region of gp130 that is essential for Stat3 activation
16. Applications of retrovirus-mediated expression cloning
17. Role of cytokine signaling molecules in erythroid differentiation of mouse fetal liver hematopoietic cells: Functional analysis of signaling molecules by retrovirus-mediated expression
18. Efficient screening of retroviral cDNA expression libraries
19. Signaling of type II oncostatin M receptor
20. Ciliary neurotrophic factor/leukemia inhibitory factor/interleukin 6/oncostatin M family of cytokines induces tyrosine phosphorylation of a common set of proteins overlapping those induced by other cytokines and growth factors
21. Activation of phosphatidylinositol 3-kinase through glycoprotein 130 induces protein kinase B and p70 S6 kinase phosphorylation in cardiac myocytes
22. Suppression of interleukin-3-induced gene expression by a C-terminal truncated Stat5: Role of Stats in proliferation
23. Role of SH-PTP2, a protein-tyrosine phosphatase with Src homology 2 domains, in insulin-stimulated Ras activation
24. A common requirement for the catalytic activity and both SH2 domains of SHP-2 in mitogen-activated protein (MAP) kinase activation by the ErbB family of receptors. A specific role for SHP-2 in map, but not c-Jun amino-terminal kinase activation
25. The SH2-containing protein-tyrosine phosphatase SH-PTP2 is required upstream of MAP kinase for early Xenopus development
26. PTP1D is a positive regulator of the prolactin signal leading to betacasein promoter activation
27. PI 3-kinase is a dual specificity enzyme: Autoregulation by an intrinsic protein-serine kinase activity
28. Functional interactions between Stat5 and the glucocorticoid receptor
29. Crosstalk between the interleukin-6 (IL-6)-JAK-STAT and the glucocorticoid-nuclear receptor pathway: Synergistic activation of IL-6 response element by IL-6 and glucocorticoid
30. STAT3 acts as a co-activator of glucocorticoid receptor signaling
31. Impaired energy homeostasis in C/EBP alpha knockout mice
32. C/EBP alpha is critical for the neonatal acute-phase response to inflammation
33. Hepatocyte nuclear factor 4 provokes expression of epithelial marker genes, acting as a morphogen in dedifferentiated heparoma cells
34. K-ras is an essential gene in the mouse with partial functional overlap with N-ras
35. K-ras is essential for the development of the mouse embryo
36. Liver degeneration and lymphoid deficiencies in mice lacking suppressor of cytokine signaling-1
37. Accelerated apoptosis of lymphocytes by augmented induction of Bax in SSI-1 (STAT-induced STAT inhibitor-1) deficient mice
38. Structure and function of a new STAT-induced STAT inhibitor
39. A new protein containing an SH2 domain that inhibits JAK kinases
40. A family of cytokine-inducible inhibitors of signalling