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Volumn 93, Issue , 2016, Pages 175-185

Aging and the cardiac collagen matrix: Novel mediators of fibrotic remodelling

Author keywords

Aging; Collagen; Extracellular matrix; Fibrosis; Heart failure

Indexed keywords

CARDIOTROPHIN 1; COLLAGEN; GALECTIN 3; MATRIX METALLOPROTEINASE; MICRORNA; RELAXIN; TISSUE INHIBITOR OF METALLOPROTEINASE; BIOLOGICAL MARKER;

EID: 84949661774     PISSN: 00222828     EISSN: 10958584     Source Type: Journal    
DOI: 10.1016/j.yjmcc.2015.11.005     Document Type: Review
Times cited : (200)

References (204)
  • 1
    • 0037425535 scopus 로고    scopus 로고
    • Burden of systolic and diastolic ventricular dysfunction in the community: appreciating the scope of the heart failure epidemic
    • Redfield M.M., Jacobsen S.J., Burnett J.C., Mahoney D.W., Bailey K.R., Rodeheffer R.J. Burden of systolic and diastolic ventricular dysfunction in the community: appreciating the scope of the heart failure epidemic. J. Am. Med. Assoc. 2003, 289:194-202.
    • (2003) J. Am. Med. Assoc. , vol.289 , pp. 194-202
    • Redfield, M.M.1    Jacobsen, S.J.2    Burnett, J.C.3    Mahoney, D.W.4    Bailey, K.R.5    Rodeheffer, R.J.6
  • 2
    • 77955718033 scopus 로고    scopus 로고
    • Aging and heart failure: changing demographics and implications for therapy in the elderly
    • Jugdutt B.I. Aging and heart failure: changing demographics and implications for therapy in the elderly. Heart Fail. Rev. 2010, 15:401-405.
    • (2010) Heart Fail. Rev. , vol.15 , pp. 401-405
    • Jugdutt, B.I.1
  • 3
    • 79955162230 scopus 로고    scopus 로고
    • The persistent exclusion of older patients from ongoing clinical trials regarding heart failure
    • Cherubini A., Oristrell J., Pla X., Ruggiero C., Ferretti R., Diestre G., et al. The persistent exclusion of older patients from ongoing clinical trials regarding heart failure. Arch. Intern. Med. 2011, 171:550-556.
    • (2011) Arch. Intern. Med. , vol.171 , pp. 550-556
    • Cherubini, A.1    Oristrell, J.2    Pla, X.3    Ruggiero, C.4    Ferretti, R.5    Diestre, G.6
  • 4
    • 77950591512 scopus 로고    scopus 로고
    • Disparate inclusion of older adults in clinical trials: priorities and opportunities for policy and practice change
    • Herrera A.P., Snipes S.A., King D.W., Torres-Vigil I., Goldberg D.S., Weinberg A.D. Disparate inclusion of older adults in clinical trials: priorities and opportunities for policy and practice change. Am. J. Public Health 2010, 100(Suppl. 1). (S105-S12).
    • (2010) Am. J. Public Health , vol.100 , pp. S105-S112
    • Herrera, A.P.1    Snipes, S.A.2    King, D.W.3    Torres-Vigil, I.4    Goldberg, D.S.5    Weinberg, A.D.6
  • 5
    • 84859117778 scopus 로고    scopus 로고
    • Underrepresentation of elderly people in randomised controlled trials. The example of trials of 4 widely prescribed drugs
    • Konrat C., Boutron I., Trinquart L., Auleley G.R., Ricordeau P., Ravaud P. Underrepresentation of elderly people in randomised controlled trials. The example of trials of 4 widely prescribed drugs. PLoS One 2012, 7.
    • (2012) PLoS One , vol.7
    • Konrat, C.1    Boutron, I.2    Trinquart, L.3    Auleley, G.R.4    Ricordeau, P.5    Ravaud, P.6
  • 6
    • 0008235624 scopus 로고    scopus 로고
    • Necrotic and apoptotic myocyte cell death in the aging heart of Fischer 344 rats
    • Kajstura J., Cheng W., Sarangarajan R., Li P., Li B., Nitahara J.A., et al. Necrotic and apoptotic myocyte cell death in the aging heart of Fischer 344 rats. Am. J. Phys. 1996, 271:H1215-H1228.
    • (1996) Am. J. Phys. , vol.271 , pp. H1215-H1228
    • Kajstura, J.1    Cheng, W.2    Sarangarajan, R.3    Li, P.4    Li, B.5    Nitahara, J.A.6
  • 7
    • 79954606808 scopus 로고    scopus 로고
    • Programmed necrosis, not apoptosis, in the heart
    • Kung G., Konstantinidis K., Kitsis R.N. Programmed necrosis, not apoptosis, in the heart. Circ. Res. 2011, 108:1017-1036.
    • (2011) Circ. Res. , vol.108 , pp. 1017-1036
    • Kung, G.1    Konstantinidis, K.2    Kitsis, R.N.3
  • 8
    • 84899970069 scopus 로고    scopus 로고
    • The interplay between autophagy and mitochondrial dysfunction in oxidative stress-induced cardiac aging and pathology
    • Wohlgemuth S.E., Calvani R., Marzetti E. The interplay between autophagy and mitochondrial dysfunction in oxidative stress-induced cardiac aging and pathology. J. Mol. Cell. Cardiol. 2014, 71:62-70.
    • (2014) J. Mol. Cell. Cardiol. , vol.71 , pp. 62-70
    • Wohlgemuth, S.E.1    Calvani, R.2    Marzetti, E.3
  • 10
    • 62849126102 scopus 로고    scopus 로고
    • Relation of pulse pressure and arterial stiffness to concentric left ventricular hypertrophy in young men (from the Bogalusa Heart Study)
    • Toprak A., Reddy J., Chen W., Srinivasan S., Berenson G. Relation of pulse pressure and arterial stiffness to concentric left ventricular hypertrophy in young men (from the Bogalusa Heart Study). Am. J. Cardiol. 2009, 103:978-984.
    • (2009) Am. J. Cardiol. , vol.103 , pp. 978-984
    • Toprak, A.1    Reddy, J.2    Chen, W.3    Srinivasan, S.4    Berenson, G.5
  • 11
    • 0034713820 scopus 로고    scopus 로고
    • Left ventricular hypertrophy. Pathogenesis, detection and prognosis
    • Lorell B.H., Carabello B.A. Left ventricular hypertrophy. Pathogenesis, detection and prognosis. Circulation 2000, 102:470-479.
    • (2000) Circulation , vol.102 , pp. 470-479
    • Lorell, B.H.1    Carabello, B.A.2
  • 12
    • 84963807079 scopus 로고    scopus 로고
    • Mechanotransduction in cardiomyocyte hypertrophy
    • Taylor & Francis, Abingdon, R.A. Walsh (Ed.)
    • Samarel A.M. Mechanotransduction in cardiomyocyte hypertrophy. Molecular Mechanisms of Cardiac Hypertrophy and Failure 2005, 89-100. Taylor & Francis, Abingdon. R.A. Walsh (Ed.).
    • (2005) Molecular Mechanisms of Cardiac Hypertrophy and Failure , pp. 89-100
    • Samarel, A.M.1
  • 14
    • 0025801813 scopus 로고
    • Cardiomyopathy of the aging human heart. Myocyte loss and reactive cellular hypertrophy
    • Olivetti G., Melissari M., Capasso J.M., Anversa P. Cardiomyopathy of the aging human heart. Myocyte loss and reactive cellular hypertrophy. Circ. Res. 1991, 68:1560-1568.
    • (1991) Circ. Res. , vol.68 , pp. 1560-1568
    • Olivetti, G.1    Melissari, M.2    Capasso, J.M.3    Anversa, P.4
  • 16
    • 67249152096 scopus 로고    scopus 로고
    • Cardiac fibroblasts: at the heart of myocardial remodeling
    • Porter K.E., Turner N.A. Cardiac fibroblasts: at the heart of myocardial remodeling. Pharmacol. Ther. 2009, 123:255-278.
    • (2009) Pharmacol. Ther. , vol.123 , pp. 255-278
    • Porter, K.E.1    Turner, N.A.2
  • 17
    • 11144346203 scopus 로고    scopus 로고
    • Structural and functional characterisation of cardiac fibroblasts
    • Camelliti P., Borg T.K., Kohl P. Structural and functional characterisation of cardiac fibroblasts. Cardiovasc. Res. 2005, 65:40-51.
    • (2005) Cardiovasc. Res. , vol.65 , pp. 40-51
    • Camelliti, P.1    Borg, T.K.2    Kohl, P.3
  • 18
    • 0035979497 scopus 로고    scopus 로고
    • Age related changes of the collagen network of the human heart
    • Debessa C.R.G., Maifrino L.B.M., de Souza R.R. Age related changes of the collagen network of the human heart. Mech. Aging Dev. 2001, 122:1049-1058.
    • (2001) Mech. Aging Dev. , vol.122 , pp. 1049-1058
    • Debessa, C.R.G.1    Maifrino, L.B.M.2    de Souza, R.R.3
  • 20
    • 84861965201 scopus 로고    scopus 로고
    • Age-related divergent remodeling of the cardiac extracellular matrix in heart failure: collagen accumulation in the young and loss in the aged
    • Horn M.A., Graham H.K., Richards M.A., Clarke J.D., Greensmith D.J., Briston S.J., et al. Age-related divergent remodeling of the cardiac extracellular matrix in heart failure: collagen accumulation in the young and loss in the aged. J. Mol. Cell. Cardiol. 2012, 53:82-90.
    • (2012) J. Mol. Cell. Cardiol. , vol.53 , pp. 82-90
    • Horn, M.A.1    Graham, H.K.2    Richards, M.A.3    Clarke, J.D.4    Greensmith, D.J.5    Briston, S.J.6
  • 22
    • 0037458070 scopus 로고    scopus 로고
    • Arterial and cardiac aging: major shareholders in cardiovascular disease enterprises: part II: the aging heart in health: links to heart disease
    • Lakatta E.G., Levy D. Arterial and cardiac aging: major shareholders in cardiovascular disease enterprises: part II: the aging heart in health: links to heart disease. Circulation 2003, 107:346-354.
    • (2003) Circulation , vol.107 , pp. 346-354
    • Lakatta, E.G.1    Levy, D.2
  • 23
    • 0028328457 scopus 로고
    • Cardiovascular responses to exercise. Effects of aging and exercise training in healthy men
    • Stratton J.R., Levy W.C., Cerqueira M.D., Schwartz R.S., Abrass I.B. Cardiovascular responses to exercise. Effects of aging and exercise training in healthy men. Circulation 1994, 89:1648-1655.
    • (1994) Circulation , vol.89 , pp. 1648-1655
    • Stratton, J.R.1    Levy, W.C.2    Cerqueira, M.D.3    Schwartz, R.S.4    Abrass, I.B.5
  • 24
    • 0035865536 scopus 로고    scopus 로고
    • Importance of heart failure with preserved systolic function in patients > or =65 years of age. CHS Research Group. Cardiovascular Health Study
    • Kitzman D.W., Gardin J.M., Gottdiener J.S., Arnold A., Boineau R., Aurigemma G., et al. Importance of heart failure with preserved systolic function in patients > or =65 years of age. CHS Research Group. Cardiovascular Health Study. Am. J. Cardiol. 2001, 87:413-419.
    • (2001) Am. J. Cardiol. , vol.87 , pp. 413-419
    • Kitzman, D.W.1    Gardin, J.M.2    Gottdiener, J.S.3    Arnold, A.4    Boineau, R.5    Aurigemma, G.6
  • 25
    • 4644272249 scopus 로고    scopus 로고
    • Effect of aging and physical activity on left ventricular compliance
    • Arbab-Zadeh A., Dijk E., Prasad A., Fu Q., Torres P., Zhang R., et al. Effect of aging and physical activity on left ventricular compliance. Circulation 2004, 110:1799-1805.
    • (2004) Circulation , vol.110 , pp. 1799-1805
    • Arbab-Zadeh, A.1    Dijk, E.2    Prasad, A.3    Fu, Q.4    Torres, P.5    Zhang, R.6
  • 26
    • 84962905872 scopus 로고    scopus 로고
    • Cardiac physiology of aging: extracellular considerations
    • Horn M.A. Cardiac physiology of aging: extracellular considerations. Compr. Physiol. 2015, 5:1069-1121.
    • (2015) Compr. Physiol. , vol.5 , pp. 1069-1121
    • Horn, M.A.1
  • 29
    • 48949085760 scopus 로고    scopus 로고
    • Extracellular matrix profiles in the progression to heart failure
    • Graham H.K., Horn M., Trafford A.W. Extracellular matrix profiles in the progression to heart failure. Acta Physiol. 2008, 194:3-21.
    • (2008) Acta Physiol. , vol.194 , pp. 3-21
    • Graham, H.K.1    Horn, M.2    Trafford, A.W.3
  • 30
    • 0035028665 scopus 로고    scopus 로고
    • The extracellular matrix in normal and diseased myocardium
    • Hein S., Schaper J. The extracellular matrix in normal and diseased myocardium. J. Nucl. Cardiol. 2001, 8:188-196.
    • (2001) J. Nucl. Cardiol. , vol.8 , pp. 188-196
    • Hein, S.1    Schaper, J.2
  • 31
    • 84861537861 scopus 로고    scopus 로고
    • The epidermal basement membrane is a composite of separate laminin- or collagen IV-containing networks connected by aggregated perlecan, but not by nidogens
    • Behrens D.T., Villone D., Koch M., Brunner G., Sorokin L., Robenek H., et al. The epidermal basement membrane is a composite of separate laminin- or collagen IV-containing networks connected by aggregated perlecan, but not by nidogens. J. Biol. Chem. 2012, 287:18700-18709.
    • (2012) J. Biol. Chem. , vol.287 , pp. 18700-18709
    • Behrens, D.T.1    Villone, D.2    Koch, M.3    Brunner, G.4    Sorokin, L.5    Robenek, H.6
  • 32
    • 0033711108 scopus 로고    scopus 로고
    • The extracellular matrix and the cytoskeleton in heart hypertrophy and failure
    • Jane-Lise S., Corda S., Chassagne C., Rappaport L. The extracellular matrix and the cytoskeleton in heart hypertrophy and failure. Heart Fail. Rev. 2000, 5:239-250.
    • (2000) Heart Fail. Rev. , vol.5 , pp. 239-250
    • Jane-Lise, S.1    Corda, S.2    Chassagne, C.3    Rappaport, L.4
  • 33
    • 0035827723 scopus 로고    scopus 로고
    • Integrins and the myocardium
    • Ross R.S., Borg T.K. Integrins and the myocardium. Circ. Res. 2001, 88:1112-1119.
    • (2001) Circ. Res. , vol.88 , pp. 1112-1119
    • Ross, R.S.1    Borg, T.K.2
  • 34
    • 7444256134 scopus 로고    scopus 로고
    • Contraction augments L-type Ca2+ currents in adherent guinea-pig cardiomyocytes
    • Rueckschloss U., Isenberg G. Contraction augments L-type Ca2+ currents in adherent guinea-pig cardiomyocytes. J. Physiol. 2004, 560:403-411.
    • (2004) J. Physiol. , vol.560 , pp. 403-411
    • Rueckschloss, U.1    Isenberg, G.2
  • 35
    • 0034235527 scopus 로고    scopus 로고
    • Laminin acts via beta 1 integrin signalling to alter cholinergic regulation of L-type Ca(2+) current in cat atrial myocytes
    • Wang Y.G., Samarel A.M., Lipsius S.L. Laminin acts via beta 1 integrin signalling to alter cholinergic regulation of L-type Ca(2+) current in cat atrial myocytes. J. Physiol. 2000, 526(Pt 1):57-68.
    • (2000) J. Physiol. , vol.526 , pp. 57-68
    • Wang, Y.G.1    Samarel, A.M.2    Lipsius, S.L.3
  • 36
    • 0030453194 scopus 로고    scopus 로고
    • Integrins can collaborate with growth factors for phosphorylation of receptor tyrosine kinases and MAP kinase activation: roles of integrin aggregation and occupancy of receptors
    • Miyamoto S., Teramoto H., Gutkind J.S., Yamada K.M. Integrins can collaborate with growth factors for phosphorylation of receptor tyrosine kinases and MAP kinase activation: roles of integrin aggregation and occupancy of receptors. J. Cell Biol. 1996, 135:1633-1642.
    • (1996) J. Cell Biol. , vol.135 , pp. 1633-1642
    • Miyamoto, S.1    Teramoto, H.2    Gutkind, J.S.3    Yamada, K.M.4
  • 37
    • 84947996697 scopus 로고    scopus 로고
    • Integrins and integrin-related proteins in cardiac fibrosis
    • (in this issue)
    • Chen C., Li R., Ross R.S., Manso A.M. Integrins and integrin-related proteins in cardiac fibrosis. J. Mol. Cell. Cardiol. 2016, 93:162-174. (in this issue).
    • (2016) J. Mol. Cell. Cardiol. , vol.93 , pp. 162-174
    • Chen, C.1    Li, R.2    Ross, R.S.3    Manso, A.M.4
  • 38
    • 84948969177 scopus 로고    scopus 로고
    • Aging-related changes in extracellular matrix: implications for ventricular remodeling following myocardial infarction
    • Springer, New York, NY, B.I. Jugdutt (Ed.)
    • Nguyen N., Yabluchanskiy A., de Castro Bras L.E., Jin Y.F., Lindsey M.L. Aging-related changes in extracellular matrix: implications for ventricular remodeling following myocardial infarction. Aging and Heart Failure: Mechanisms and Management 2014, 377-389. Springer, New York, NY. B.I. Jugdutt (Ed.).
    • (2014) Aging and Heart Failure: Mechanisms and Management , pp. 377-389
    • Nguyen, N.1    Yabluchanskiy, A.2    de Castro Bras, L.E.3    Jin, Y.F.4    Lindsey, M.L.5
  • 40
    • 0141653901 scopus 로고    scopus 로고
    • Ventricular remodeling after infarction and the extracellular collagen matrix: when is enough enough?
    • Jugdutt B.I. Ventricular remodeling after infarction and the extracellular collagen matrix: when is enough enough?. Circulation 2003, 108:1395-1403.
    • (2003) Circulation , vol.108 , pp. 1395-1403
    • Jugdutt, B.I.1
  • 43
    • 84899113897 scopus 로고    scopus 로고
    • Fibroblast-myocyte electrotonic coupling: does it occur in native cardiac tissue?
    • Kohl P., Gourdie R.G. Fibroblast-myocyte electrotonic coupling: does it occur in native cardiac tissue?. J. Mol. Cell. Cardiol. 2014, 70:37-46.
    • (2014) J. Mol. Cell. Cardiol. , vol.70 , pp. 37-46
    • Kohl, P.1    Gourdie, R.G.2
  • 44
    • 84930741570 scopus 로고    scopus 로고
    • Getting to the heart of the matter: new insights into cardiac fibrosis
    • Leask A. Getting to the heart of the matter: new insights into cardiac fibrosis. Circ. Res. 2015, 116:1269-1276.
    • (2015) Circ. Res. , vol.116 , pp. 1269-1276
    • Leask, A.1
  • 45
    • 0025882771 scopus 로고
    • Collagen expression in mechanically stimulated cardiac fibroblasts
    • Carver W., Nagpal M.L., Nachtigal M., Borg T.K., Terracio L. Collagen expression in mechanically stimulated cardiac fibroblasts. Circ. Res. 1991, 69:116-122.
    • (1991) Circ. Res. , vol.69 , pp. 116-122
    • Carver, W.1    Nagpal, M.L.2    Nachtigal, M.3    Borg, T.K.4    Terracio, L.5
  • 46
    • 0023739984 scopus 로고
    • Coiled perimysial fibers of papillary muscle in rat heart: morphology, distribution, and changes in configuration
    • Robinson T.F., Geraci M.A., Sonnenblick E.H., Factor S.M. Coiled perimysial fibers of papillary muscle in rat heart: morphology, distribution, and changes in configuration. Circ. Res. 1988, 63:577-592.
    • (1988) Circ. Res. , vol.63 , pp. 577-592
    • Robinson, T.F.1    Geraci, M.A.2    Sonnenblick, E.H.3    Factor, S.M.4
  • 47
    • 84864915724 scopus 로고    scopus 로고
    • Structural and biomechanical characterizations of porcine myocardial extracellular matrix
    • Wang B., Tedder M., Perez C., Wang G., Jongh Curry A., To F., et al. Structural and biomechanical characterizations of porcine myocardial extracellular matrix. J. Mater. Sci. Mater. Med. 2012, 23:1835-1847.
    • (2012) J. Mater. Sci. Mater. Med. , vol.23 , pp. 1835-1847
    • Wang, B.1    Tedder, M.2    Perez, C.3    Wang, G.4    Jongh Curry, A.5    To, F.6
  • 48
    • 24644490545 scopus 로고    scopus 로고
    • Elastin stabilizes an infarct and preserves ventricular function
    • Mizuno T., Yau T.M., Weisel R.D., Kiani C.G., Li R.K. Elastin stabilizes an infarct and preserves ventricular function. Circulation 2005, 112:I-81.
    • (2005) Circulation , vol.112 , pp. I-81
    • Mizuno, T.1    Yau, T.M.2    Weisel, R.D.3    Kiani, C.G.4    Li, R.K.5
  • 49
    • 76549214686 scopus 로고
    • The determination of collagen and elastin in tissues
    • Neuman R.E., Logan M.A. The determination of collagen and elastin in tissues. J. Biol. Chem. 1950, 186:549-556.
    • (1950) J. Biol. Chem. , vol.186 , pp. 549-556
    • Neuman, R.E.1    Logan, M.A.2
  • 50
    • 0026537220 scopus 로고
    • Isolation, characterization, and localization of cardiac collagen type VI. Associations with other extracellular matrix components
    • Bashey R.I., Martinez-Hernandez A., Jimenez S.A. Isolation, characterization, and localization of cardiac collagen type VI. Associations with other extracellular matrix components. Circ. Res. 1992, 70:1006-1017.
    • (1992) Circ. Res. , vol.70 , pp. 1006-1017
    • Bashey, R.I.1    Martinez-Hernandez, A.2    Jimenez, S.A.3
  • 51
    • 85047676664 scopus 로고
    • Characterisation of left ventricular collagen in the rat
    • Medugorac I., Jacob R. Characterisation of left ventricular collagen in the rat. Cardiovasc. Res. 1983, 17:15-21.
    • (1983) Cardiovasc. Res. , vol.17 , pp. 15-21
    • Medugorac, I.1    Jacob, R.2
  • 52
    • 0027058386 scopus 로고
    • Cardiac dilatation associated with collagen alterations
    • Caulfield J.B., Norton P., Weaver R.D. Cardiac dilatation associated with collagen alterations. Mol. Cell. Biochem. 1992, 118:171-179.
    • (1992) Mol. Cell. Biochem. , vol.118 , pp. 171-179
    • Caulfield, J.B.1    Norton, P.2    Weaver, R.D.3
  • 55
    • 0023085856 scopus 로고
    • Alterations of the myocardial skeletal framework in acute myocardial infarction with and without ventricular rupture. A preliminary report
    • Factor S.M., Robinson T.F., Dominitz R., Cho S. Alterations of the myocardial skeletal framework in acute myocardial infarction with and without ventricular rupture. A preliminary report. Am. J. Cardiovasc. Pathol. 1986, 1:91-97.
    • (1986) Am. J. Cardiovasc. Pathol. , vol.1 , pp. 91-97
    • Factor, S.M.1    Robinson, T.F.2    Dominitz, R.3    Cho, S.4
  • 56
    • 0024410697 scopus 로고
    • Fibrillar collagen and myocardial stiffness in the intact hypertrophied rat left ventricle
    • Jalil J.E., Doering C.W., Janicki J.S., Pick R., Shroff S.G., Weber K.T. Fibrillar collagen and myocardial stiffness in the intact hypertrophied rat left ventricle. Circ. Res. 1989, 64:1041-1050.
    • (1989) Circ. Res. , vol.64 , pp. 1041-1050
    • Jalil, J.E.1    Doering, C.W.2    Janicki, J.S.3    Pick, R.4    Shroff, S.G.5    Weber, K.T.6
  • 58
    • 0029135237 scopus 로고
    • Inhibition of collagen cross-linking: effects on fibrillar collagen and ventricular diastolic function
    • Kato S., Spinale F.G., Tanaka R., Johnson W., Cooper G., Zile M.R. Inhibition of collagen cross-linking: effects on fibrillar collagen and ventricular diastolic function. Am. J. Phys. 1995, 269:H863-H868.
    • (1995) Am. J. Phys. , vol.269 , pp. H863-H868
    • Kato, S.1    Spinale, F.G.2    Tanaka, R.3    Johnson, W.4    Cooper, G.5    Zile, M.R.6
  • 59
    • 77957255499 scopus 로고    scopus 로고
    • Pirfenidone mitigates left ventricular fibrosis and dysfunction after myocardial infarction and reduces arrhythmias
    • Nguyen D.T., Ding C., Wilson E., Marcus G.M., Olgin J.E. Pirfenidone mitigates left ventricular fibrosis and dysfunction after myocardial infarction and reduces arrhythmias. Heart Rhythm. 2010, 7:1438-1445.
    • (2010) Heart Rhythm. , vol.7 , pp. 1438-1445
    • Nguyen, D.T.1    Ding, C.2    Wilson, E.3    Marcus, G.M.4    Olgin, J.E.5
  • 60
    • 60549088560 scopus 로고    scopus 로고
    • Absence of SPARC results in increased cardiac rupture and dysfunction after acute myocardial infarction
    • Schellings M.W., Vanhoutte D., Swinnen M., Cleutjens J.P., Debets J., van Leeuwen R.E., et al. Absence of SPARC results in increased cardiac rupture and dysfunction after acute myocardial infarction. J. Exp. Med. 2009, 206:113-123.
    • (2009) J. Exp. Med. , vol.206 , pp. 113-123
    • Schellings, M.W.1    Vanhoutte, D.2    Swinnen, M.3    Cleutjens, J.P.4    Debets, J.5    van Leeuwen, R.E.6
  • 61
    • 4444312145 scopus 로고    scopus 로고
    • Thrombospondin-2 is essential for myocardial matrix integrity: increased expression identifies failure-prone cardiac hypertrophy
    • Schroen B., Heymans S., Sharma U., Blankesteijn W.M., Pokharel S., Cleutjens J.P., et al. Thrombospondin-2 is essential for myocardial matrix integrity: increased expression identifies failure-prone cardiac hypertrophy. Circ. Res. 2004, 95:515-522.
    • (2004) Circ. Res. , vol.95 , pp. 515-522
    • Schroen, B.1    Heymans, S.2    Sharma, U.3    Blankesteijn, W.M.4    Pokharel, S.5    Cleutjens, J.P.6
  • 62
    • 84864005386 scopus 로고    scopus 로고
    • Effects of the absence of procollagen C-endopeptidase enhancer-2 on myocardial collagen accumulation in chronic pressure overload
    • Baicu C.F., Zhang Y., Van Laer A.O., Renaud L., Zile M.R., Bradshaw A.D. Effects of the absence of procollagen C-endopeptidase enhancer-2 on myocardial collagen accumulation in chronic pressure overload. Am. J. Physiol. Heart Circ. Physiol. 2012, 303:H234-H240.
    • (2012) Am. J. Physiol. Heart Circ. Physiol. , vol.303 , pp. H234-H240
    • Baicu, C.F.1    Zhang, Y.2    Van Laer, A.O.3    Renaud, L.4    Zile, M.R.5    Bradshaw, A.D.6
  • 63
    • 84874626027 scopus 로고    scopus 로고
    • Cellular mechanisms of tissue fibrosis. 2. Contributory pathways leading to myocardial fibrosis: moving beyond collagen expression
    • Goldsmith E.C., Bradshaw A.D., Spinale F.G. Cellular mechanisms of tissue fibrosis. 2. Contributory pathways leading to myocardial fibrosis: moving beyond collagen expression. Am. J. Physiol. Cell Physiol. 2013, 304:C393-C402.
    • (2013) Am. J. Physiol. Cell Physiol. , vol.304 , pp. C393-C402
    • Goldsmith, E.C.1    Bradshaw, A.D.2    Spinale, F.G.3
  • 64
    • 58149333154 scopus 로고    scopus 로고
    • Secreted Frizzled-related protein 2 is a procollagen C proteinase enhancer with a role in fibrosis associated with myocardial infarction
    • Kobayashi K., Luo M., Zhang Y., Wilkes D.C., Ge G., Grieskamp T., et al. Secreted Frizzled-related protein 2 is a procollagen C proteinase enhancer with a role in fibrosis associated with myocardial infarction. Nat. Cell Biol. 2009, 11:46-55.
    • (2009) Nat. Cell Biol. , vol.11 , pp. 46-55
    • Kobayashi, K.1    Luo, M.2    Zhang, Y.3    Wilkes, D.C.4    Ge, G.5    Grieskamp, T.6
  • 65
    • 50849145156 scopus 로고    scopus 로고
    • Collagen fibrillogenesis: fibronectin, integrins, and minor collagens as organizers and nucleators
    • Kadler K.E., Hill A., Canty-Laird E.G. Collagen fibrillogenesis: fibronectin, integrins, and minor collagens as organizers and nucleators. Curr. Opin. Cell Biol. 2008, 20:495-501.
    • (2008) Curr. Opin. Cell Biol. , vol.20 , pp. 495-501
    • Kadler, K.E.1    Hill, A.2    Canty-Laird, E.G.3
  • 67
    • 34547575826 scopus 로고    scopus 로고
    • SPARC regulates processing of procollagen I and collagen fibrillogenesis in dermal fibroblasts
    • Rentz T.J., Poobalarahi F., Bornstein P., Sage E.H., Bradshaw A.D. SPARC regulates processing of procollagen I and collagen fibrillogenesis in dermal fibroblasts. J. Biol. Chem. 2007, 282:22062-22071.
    • (2007) J. Biol. Chem. , vol.282 , pp. 22062-22071
    • Rentz, T.J.1    Poobalarahi, F.2    Bornstein, P.3    Sage, E.H.4    Bradshaw, A.D.5
  • 68
  • 70
    • 0023656926 scopus 로고
    • Assembly of collagen fibrils de novo by cleavage of the type I pC-collagen with procollagen C-proteinase. Assay of critical concentration demonstrates that collagen self-assembly is a classical example of an entropy-driven process
    • Kadler K.E., Hojima Y., Prockop D.J. Assembly of collagen fibrils de novo by cleavage of the type I pC-collagen with procollagen C-proteinase. Assay of critical concentration demonstrates that collagen self-assembly is a classical example of an entropy-driven process. J. Biol. Chem. 1987, 262:15696-15701.
    • (1987) J. Biol. Chem. , vol.262 , pp. 15696-15701
    • Kadler, K.E.1    Hojima, Y.2    Prockop, D.J.3
  • 73
    • 36248989151 scopus 로고    scopus 로고
    • Advanced glycation end-products (AGEs) and heart failure: pathophysiology and clinical implications
    • Hartog J.W.L., Voors A.A., Bakker S.J.L., Smit A.J., van Veldhuisen D.J. Advanced glycation end-products (AGEs) and heart failure: pathophysiology and clinical implications. Eur. J. Heart Fail. 2007, 9:1146-1155.
    • (2007) Eur. J. Heart Fail. , vol.9 , pp. 1146-1155
    • Hartog, J.W.L.1    Voors, A.A.2    Bakker, S.J.L.3    Smit, A.J.4    van Veldhuisen, D.J.5
  • 74
    • 59849107057 scopus 로고    scopus 로고
    • Impact of treatment on myocardial lysyl oxidase expression and collagen cross-linking in patients with heart failure
    • Lopez B., Querejeta R., Gonzalez A., Beaumont J., Larman M., Diez J. Impact of treatment on myocardial lysyl oxidase expression and collagen cross-linking in patients with heart failure. Hypertension 2009, 53:236-242.
    • (2009) Hypertension , vol.53 , pp. 236-242
    • Lopez, B.1    Querejeta, R.2    Gonzalez, A.3    Beaumont, J.4    Larman, M.5    Diez, J.6
  • 75
    • 84929087023 scopus 로고    scopus 로고
    • Syndecan-4 is a key determinant of collagen cross-linking and passive myocardial stiffness in the pressure-overloaded heart
    • Herum K.M., Lunde I.G., Skrbic B., Louch W.E., Hasic A., Boye S., et al. Syndecan-4 is a key determinant of collagen cross-linking and passive myocardial stiffness in the pressure-overloaded heart. Cardiovasc. Res. 2015, 106:217-226.
    • (2015) Cardiovasc. Res. , vol.106 , pp. 217-226
    • Herum, K.M.1    Lunde, I.G.2    Skrbic, B.3    Louch, W.E.4    Hasic, A.5    Boye, S.6
  • 76
    • 35748974863 scopus 로고    scopus 로고
    • Myocardial matrix remodeling and the matrix metalloproteinases: influence on cardiac form and function
    • Spinale F.G. Myocardial matrix remodeling and the matrix metalloproteinases: influence on cardiac form and function. Physiol. Rev. 2007, 87:1285-1342.
    • (2007) Physiol. Rev. , vol.87 , pp. 1285-1342
    • Spinale, F.G.1
  • 77
    • 84874285627 scopus 로고    scopus 로고
    • Matrix metalloproteinase-28 deletion exacerbates cardiac dysfunction and rupture after myocardial infarction in mice by inhibiting M2 macrophage activation
    • Ma Y., Halade G.V., Zhang J., Ramirez T.A., Levin D., Voorhees A., et al. Matrix metalloproteinase-28 deletion exacerbates cardiac dysfunction and rupture after myocardial infarction in mice by inhibiting M2 macrophage activation. Circ. Res. 2013, 112:675-688.
    • (2013) Circ. Res. , vol.112 , pp. 675-688
    • Ma, Y.1    Halade, G.V.2    Zhang, J.3    Ramirez, T.A.4    Levin, D.5    Voorhees, A.6
  • 78
    • 1842338681 scopus 로고    scopus 로고
    • Limited cleavage of extracellular matrix protein BM-40 by matrix metalloproteinases increases its affinity for collagens
    • Sasaki T., Gohring W., Mann K., Maurer P., Hohenester E., Knauper V., et al. Limited cleavage of extracellular matrix protein BM-40 by matrix metalloproteinases increases its affinity for collagens. J. Biol. Chem. 1997, 272:9237-9243.
    • (1997) J. Biol. Chem. , vol.272 , pp. 9237-9243
    • Sasaki, T.1    Gohring, W.2    Mann, K.3    Maurer, P.4    Hohenester, E.5    Knauper, V.6
  • 79
    • 0030758452 scopus 로고    scopus 로고
    • Recombinant and tissue-derived mouse BM-40 bind to several collagen types and have increased affinities after proteolytic activation
    • Maurer P., Gohring W., Sasaki T., Mann K., Timpl R., Nischt R. Recombinant and tissue-derived mouse BM-40 bind to several collagen types and have increased affinities after proteolytic activation. Cell. Mol. Life Sci. 1997, 53:478-484.
    • (1997) Cell. Mol. Life Sci. , vol.53 , pp. 478-484
    • Maurer, P.1    Gohring, W.2    Sasaki, T.3    Mann, K.4    Timpl, R.5    Nischt, R.6
  • 80
    • 0037114003 scopus 로고    scopus 로고
    • Matrix metalloproteinase-dependent activation of latent transforming growth factor-β controls the conversion of osteoblasts into osteocytes by blocking osteoblast apoptosis
    • Karsdal M.A., Larsen L., Engsig M.T., Lou H., Ferreras M., Lochter A., et al. Matrix metalloproteinase-dependent activation of latent transforming growth factor-β controls the conversion of osteoblasts into osteocytes by blocking osteoblast apoptosis. J. Biol. Chem. 2002, 277:44061-44067.
    • (2002) J. Biol. Chem. , vol.277 , pp. 44061-44067
    • Karsdal, M.A.1    Larsen, L.2    Engsig, M.T.3    Lou, H.4    Ferreras, M.5    Lochter, A.6
  • 81
    • 84899905661 scopus 로고    scopus 로고
    • Mechanistic relationship between membrane type-1 matrix metalloproteinase and the myocardial response to pressure overload
    • Zile M.R., Baicu C.F., Stroud R.E., Van Laer A.O., Jones J.A., Patel R., et al. Mechanistic relationship between membrane type-1 matrix metalloproteinase and the myocardial response to pressure overload. Circ. Heart Fail. 2014, 7:340-350.
    • (2014) Circ. Heart Fail. , vol.7 , pp. 340-350
    • Zile, M.R.1    Baicu, C.F.2    Stroud, R.E.3    Van Laer, A.O.4    Jones, J.A.5    Patel, R.6
  • 82
    • 0033932709 scopus 로고    scopus 로고
    • Targeted deletion of matrix metalloproteinase-9 attenuates left ventricular enlargement and collagen accumulation after experimental myocardial infarction
    • Ducharme A., Frantz S., Aikawa M., Rabkin E., Lindsey M., Rohde L.E., et al. Targeted deletion of matrix metalloproteinase-9 attenuates left ventricular enlargement and collagen accumulation after experimental myocardial infarction. J. Clin. Invest. 2000, 106:55-62.
    • (2000) J. Clin. Invest. , vol.106 , pp. 55-62
    • Ducharme, A.1    Frantz, S.2    Aikawa, M.3    Rabkin, E.4    Lindsey, M.5    Rohde, L.E.6
  • 83
    • 0041858010 scopus 로고    scopus 로고
    • Targeted deletion of MMP-2 attenuates early LV rupture and late remodeling after experimental myocardial infarction
    • Hayashidani S., Tsutsui H., Ikeuchi M., Shiomi T., Matsusaka H., Kubota T., et al. Targeted deletion of MMP-2 attenuates early LV rupture and late remodeling after experimental myocardial infarction. Am. J. Physiol. Heart Circ. Physiol. 2003, 285. (H1229-H35).
    • (2003) Am. J. Physiol. Heart Circ. Physiol. , vol.285 , pp. H1229-H1235
    • Hayashidani, S.1    Tsutsui, H.2    Ikeuchi, M.3    Shiomi, T.4    Matsusaka, H.5    Kubota, T.6
  • 84
    • 77956914017 scopus 로고    scopus 로고
    • Cardiac restricted overexpression of membrane type-1 matrix metalloproteinase causes adverse myocardial remodeling following myocardial infarction
    • Spinale F.G., Mukherjee R., Zavadzkas J.A., Koval C.N., Bouges S., Stroud R.E., et al. Cardiac restricted overexpression of membrane type-1 matrix metalloproteinase causes adverse myocardial remodeling following myocardial infarction. J. Biol. Chem. 2010, 285:30316-30327.
    • (2010) J. Biol. Chem. , vol.285 , pp. 30316-30327
    • Spinale, F.G.1    Mukherjee, R.2    Zavadzkas, J.A.3    Koval, C.N.4    Bouges, S.5    Stroud, R.E.6
  • 85
    • 77649273607 scopus 로고    scopus 로고
    • TIMPs and cardiac remodeling: 'embracing the MMP-independent-side of the family'
    • Vanhoutte D., Heymans S. TIMPs and cardiac remodeling: 'embracing the MMP-independent-side of the family'. J. Mol. Cell. Cardiol. 2010, 48:445-453.
    • (2010) J. Mol. Cell. Cardiol. , vol.48 , pp. 445-453
    • Vanhoutte, D.1    Heymans, S.2
  • 87
    • 77949366805 scopus 로고    scopus 로고
    • TIMP2 deficiency accelerates adverse post-myocardial infarction remodeling because of enhanced MT1-MMP activity despite lack of MMP2 activation
    • Kandalam V., Basu R., Abraham T., Wang X., Soloway P.D., Jaworski D.M., et al. TIMP2 deficiency accelerates adverse post-myocardial infarction remodeling because of enhanced MT1-MMP activity despite lack of MMP2 activation. Circ. Res. 2010, 106:796-808.
    • (2010) Circ. Res. , vol.106 , pp. 796-808
    • Kandalam, V.1    Basu, R.2    Abraham, T.3    Wang, X.4    Soloway, P.D.5    Jaworski, D.M.6
  • 88
    • 84904337178 scopus 로고    scopus 로고
    • Differential role of TIMP2 and TIMP3 in cardiac hypertrophy, fibrosis, and diastolic dysfunction
    • Fan D., Takawale A., Basu R., Patel V., Lee J., Kandalam V., et al. Differential role of TIMP2 and TIMP3 in cardiac hypertrophy, fibrosis, and diastolic dysfunction. Cardiovasc. Res. 2014, 103:268-280.
    • (2014) Cardiovasc. Res. , vol.103 , pp. 268-280
    • Fan, D.1    Takawale, A.2    Basu, R.3    Patel, V.4    Lee, J.5    Kandalam, V.6
  • 89
    • 84896780190 scopus 로고    scopus 로고
    • Translating Koch's postulates to identify matrix metalloproteinase roles in postmyocardial infarction remodeling: cardiac metalloproteinase actions (CarMA) postulates
    • Iyer R.P., de Castro Brás L.E., Jin Y.-F., Lindsey M.L. Translating Koch's postulates to identify matrix metalloproteinase roles in postmyocardial infarction remodeling: cardiac metalloproteinase actions (CarMA) postulates. Circ. Res. 2014, 114:860-871.
    • (2014) Circ. Res. , vol.114 , pp. 860-871
    • Iyer, R.P.1    de Castro Brás, L.E.2    Jin, Y.-F.3    Lindsey, M.L.4
  • 90
    • 0037155784 scopus 로고    scopus 로고
    • Matrix metalloproteinases: regulation and dysregulation in the failing heart
    • Spinale F.G. Matrix metalloproteinases: regulation and dysregulation in the failing heart. Circ. Res. 2002, 90:520-530.
    • (2002) Circ. Res. , vol.90 , pp. 520-530
    • Spinale, F.G.1
  • 91
    • 40649109044 scopus 로고    scopus 로고
    • Age-related cardiac muscle sarcopenia: combining experimental and mathematical modeling to identify mechanisms
    • Lin J., Lopez E.F., Jin Y., Van Remmen H., Bauch T., Han H.C., et al. Age-related cardiac muscle sarcopenia: combining experimental and mathematical modeling to identify mechanisms. Exp. Gerontol. 2008, 43:296-306.
    • (2008) Exp. Gerontol. , vol.43 , pp. 296-306
    • Lin, J.1    Lopez, E.F.2    Jin, Y.3    Van Remmen, H.4    Bauch, T.5    Han, H.C.6
  • 92
    • 77955175733 scopus 로고    scopus 로고
    • Aging-related early changes in markers of ventricular and matrix remodeling after reperfused ST-segment elevation myocardial infarction in the canine model: effect of early therapy with an angiotensin II type 1 receptor blocker
    • Jugdutt B.I., Jelani A., Palaniyappan A., Idikio H., Uweira R.E., Menon V., et al. Aging-related early changes in markers of ventricular and matrix remodeling after reperfused ST-segment elevation myocardial infarction in the canine model: effect of early therapy with an angiotensin II type 1 receptor blocker. Circulation 2010, 122:341-351.
    • (2010) Circulation , vol.122 , pp. 341-351
    • Jugdutt, B.I.1    Jelani, A.2    Palaniyappan, A.3    Idikio, H.4    Uweira, R.E.5    Menon, V.6
  • 94
    • 84881180925 scopus 로고    scopus 로고
    • Evaluation of age-related interstitial myocardial fibrosis with cardiac magnetic resonance contrast-enhanced T1 mapping: MESA (Multi-Ethnic Study of Atherosclerosis)
    • Liu C.Y., Liu Y.C., Wu C., Armstrong A., Volpe G.J., van der Geest R.J., et al. Evaluation of age-related interstitial myocardial fibrosis with cardiac magnetic resonance contrast-enhanced T1 mapping: MESA (Multi-Ethnic Study of Atherosclerosis). J. Am. Coll. Cardiol. 2013, 62:1280-1287.
    • (2013) J. Am. Coll. Cardiol. , vol.62 , pp. 1280-1287
    • Liu, C.Y.1    Liu, Y.C.2    Wu, C.3    Armstrong, A.4    Volpe, G.J.5    van der Geest, R.J.6
  • 95
    • 84879206750 scopus 로고    scopus 로고
    • Myocardial extracellular volume fraction from T1 measurements in healthy volunteers and mice: relationship to aging and cardiac dimensions
    • Neilan T.G., Coelho-Filho O.R., Shah R.V., Abbasi S.A., Heydari B., Watanabe E., et al. Myocardial extracellular volume fraction from T1 measurements in healthy volunteers and mice: relationship to aging and cardiac dimensions. J. Am. Coll. Cardiol. Img. 2013, 6:672-683.
    • (2013) J. Am. Coll. Cardiol. Img. , vol.6 , pp. 672-683
    • Neilan, T.G.1    Coelho-Filho, O.R.2    Shah, R.V.3    Abbasi, S.A.4    Heydari, B.5    Watanabe, E.6
  • 96
    • 0028283259 scopus 로고
    • Alterations in cardiac gene expression during the transition from stable hypertrophy to heart failure
    • Boluyt M.O., O'Neill L., Meredith A.L., Bing O.H.L., Brooks W.W., Conrad C.H., et al. Alterations in cardiac gene expression during the transition from stable hypertrophy to heart failure. Circ. Res. 1994, 75:23-32.
    • (1994) Circ. Res. , vol.75 , pp. 23-32
    • Boluyt, M.O.1    O'Neill, L.2    Meredith, A.L.3    Bing, O.H.L.4    Brooks, W.W.5    Conrad, C.H.6
  • 97
    • 4444229005 scopus 로고    scopus 로고
    • Increased collagen type I synthesis in patients with heart failure of hypertensive origin: relation to myocardial fibrosis
    • Querejeta R., Lopez B., Gonzalez A., Sanchez E., Larman M., Martinez Ubago J.L., et al. Increased collagen type I synthesis in patients with heart failure of hypertensive origin: relation to myocardial fibrosis. Circulation 2004, 110:1263-1268.
    • (2004) Circulation , vol.110 , pp. 1263-1268
    • Querejeta, R.1    Lopez, B.2    Gonzalez, A.3    Sanchez, E.4    Larman, M.5    Martinez Ubago, J.L.6
  • 98
    • 0002737079 scopus 로고    scopus 로고
    • Age-dependent expression of fibrosis-related genes and collagen deposition in the rat myocardium
    • Annoni G., Luvarà G., Arosio B., Gagliano N., Fiordaliso F., Santambrogio D., et al. Age-dependent expression of fibrosis-related genes and collagen deposition in the rat myocardium. Mech. Aging Dev. 1998, 101:57-72.
    • (1998) Mech. Aging Dev. , vol.101 , pp. 57-72
    • Annoni, G.1    Luvarà, G.2    Arosio, B.3    Gagliano, N.4    Fiordaliso, F.5    Santambrogio, D.6
  • 99
    • 0033774931 scopus 로고    scopus 로고
    • Collagen gene expression in rat left ventricle: interactive effect of age and exercise training
    • Thomas D.P., Zimmerman S.D., Hansen T.R., Martin D.T., McCormick R.J. Collagen gene expression in rat left ventricle: interactive effect of age and exercise training. J. Appl. Physiol. 2000, 89:1462-1468.
    • (2000) J. Appl. Physiol. , vol.89 , pp. 1462-1468
    • Thomas, D.P.1    Zimmerman, S.D.2    Hansen, T.R.3    Martin, D.T.4    McCormick, R.J.5
  • 100
    • 84869389745 scopus 로고    scopus 로고
    • Matrix metalloproteinase-9 deletion attenuates myocardial fibrosis and diastolic dysfunction in aging mice
    • Chiao Y.A., Ramirez T.A., Zamilpa R., Okoronkwo S.M., Dai Q., Zhang J., et al. Matrix metalloproteinase-9 deletion attenuates myocardial fibrosis and diastolic dysfunction in aging mice. Cardiovasc. Res. 2012, 96:444-455.
    • (2012) Cardiovasc. Res. , vol.96 , pp. 444-455
    • Chiao, Y.A.1    Ramirez, T.A.2    Zamilpa, R.3    Okoronkwo, S.M.4    Dai, Q.5    Zhang, J.6
  • 101
    • 0025822677 scopus 로고
    • Age-related changes in collagen synthesis and degradation in rat tissues: importance of degradation of newly synthesized collagen in regulating collagen production
    • Mays P.K., McAnulty R.J., Campa J.S., Lauquin G.J. Age-related changes in collagen synthesis and degradation in rat tissues: importance of degradation of newly synthesized collagen in regulating collagen production. Biochem. J. 1991, 276:307-313.
    • (1991) Biochem. J. , vol.276 , pp. 307-313
    • Mays, P.K.1    McAnulty, R.J.2    Campa, J.S.3    Lauquin, G.J.4
  • 102
    • 0028587567 scopus 로고
    • Nonsynchronous changes in myocardial collagen mRNA and protein during aging: effect of DOCA-salt hypertension
    • Besse S., Robert V., Assayag P., Delcayre C., Swynghedauw B. Nonsynchronous changes in myocardial collagen mRNA and protein during aging: effect of DOCA-salt hypertension. Am. J. Phys. 1994, 267. (H2237-H44).
    • (1994) Am. J. Phys. , vol.267 , pp. H2237-H2244
    • Besse, S.1    Robert, V.2    Assayag, P.3    Delcayre, C.4    Swynghedauw, B.5
  • 104
    • 84870010314 scopus 로고    scopus 로고
    • Diastolic dysfunction of aging is independent of myocardial structure but associated with plasma advanced glycation end-product levels
    • Campbell D.J., Somaratne J.B., Jenkins A.J., Prior D.L., Yii M., Kenny J.F., et al. Diastolic dysfunction of aging is independent of myocardial structure but associated with plasma advanced glycation end-product levels. PLoS One 2012, 7.
    • (2012) PLoS One , vol.7
    • Campbell, D.J.1    Somaratne, J.B.2    Jenkins, A.J.3    Prior, D.L.4    Yii, M.5    Kenny, J.F.6
  • 105
    • 0034646372 scopus 로고    scopus 로고
    • An advanced glycation endproduct cross-link breaker can reverse age-related increases in myocardial stiffness
    • Asif M., Egan J., Vasan S., Jyothirmayi G.N., Masurekar M.R., Lopez S., et al. An advanced glycation endproduct cross-link breaker can reverse age-related increases in myocardial stiffness. Proc. Natl. Acad. Sci. U. S. A. 2000, 97:2809-2813.
    • (2000) Proc. Natl. Acad. Sci. U. S. A. , vol.97 , pp. 2809-2813
    • Asif, M.1    Egan, J.2    Vasan, S.3    Jyothirmayi, G.N.4    Masurekar, M.R.5    Lopez, S.6
  • 106
    • 37549029242 scopus 로고    scopus 로고
    • The mechanisms of alloxan- and streptozotocin-induced diabetes
    • Lenzen S. The mechanisms of alloxan- and streptozotocin-induced diabetes. Diabetologia 2008, 51:216-226.
    • (2008) Diabetologia , vol.51 , pp. 216-226
    • Lenzen, S.1
  • 108
    • 77649274059 scopus 로고    scopus 로고
    • Cardiac extracellular matrix remodeling: fibrillar collagens and secreted protein acidic and rich in cysteine (SPARC)
    • McCurdy S., Baicu C.F., Heymans S., Bradshaw A.D. Cardiac extracellular matrix remodeling: fibrillar collagens and secreted protein acidic and rich in cysteine (SPARC). J. Mol. Cell. Cardiol. 2010, 48:544-549.
    • (2010) J. Mol. Cell. Cardiol. , vol.48 , pp. 544-549
    • McCurdy, S.1    Baicu, C.F.2    Heymans, S.3    Bradshaw, A.D.4
  • 109
    • 74949090210 scopus 로고    scopus 로고
    • Age-dependent alterations in fibrillar collagen content and myocardial diastolic function: role of SPARC in post-synthetic procollagen processing
    • Bradshaw A.D., Baicu C.F., Rentz T.J., Van Laer A.O., Bonnema D.D., Zile M.R. Age-dependent alterations in fibrillar collagen content and myocardial diastolic function: role of SPARC in post-synthetic procollagen processing. Am. J. Physiol. Heart Circ. Physiol. 2010, 298. (H614-H22).
    • (2010) Am. J. Physiol. Heart Circ. Physiol. , vol.298 , pp. H614-H622
    • Bradshaw, A.D.1    Baicu, C.F.2    Rentz, T.J.3    Van Laer, A.O.4    Bonnema, D.D.5    Zile, M.R.6
  • 111
    • 84955486870 scopus 로고    scopus 로고
    • The role of secreted protein acidic and rich in cysteine (SPARC) in cardiac repair and fibrosis: Does expression of SPARC by macrophages influence outcomes?
    • (in this issue)
    • Bradshaw A.D. The role of secreted protein acidic and rich in cysteine (SPARC) in cardiac repair and fibrosis: Does expression of SPARC by macrophages influence outcomes?. J. Mol. Cell. Cardiol. 2016, 93:156-161. (in this issue).
    • (2016) J. Mol. Cell. Cardiol. , vol.93 , pp. 156-161
    • Bradshaw, A.D.1
  • 112
    • 39349099135 scopus 로고    scopus 로고
    • Atrial fibrosis: mechanisms and clinical relevance in atrial fibrillation
    • Burstein B., Nattel S. Atrial fibrosis: mechanisms and clinical relevance in atrial fibrillation. J. Am. Coll. Cardiol. 2008, 51:802-809.
    • (2008) J. Am. Coll. Cardiol. , vol.51 , pp. 802-809
    • Burstein, B.1    Nattel, S.2
  • 113
    • 85047678665 scopus 로고
    • Reactive and reparative fibrillar collagen remodelling in the hypertrophied rat left ventricle: two experimental models of myocardial fibrosis
    • Silver M.A., Pick R., Brilla C.G., Jalil J.E., Janicki J.S., Weber K.T. Reactive and reparative fibrillar collagen remodelling in the hypertrophied rat left ventricle: two experimental models of myocardial fibrosis. Cardiovasc. Res. 1990, 24:741-747.
    • (1990) Cardiovasc. Res. , vol.24 , pp. 741-747
    • Silver, M.A.1    Pick, R.2    Brilla, C.G.3    Jalil, J.E.4    Janicki, J.S.5    Weber, K.T.6
  • 115
    • 77249104909 scopus 로고    scopus 로고
    • Replacement and reactive myocardial fibrosis in idiopathic dilated cardiomyopathy: comparison of magnetic resonance imaging with right ventricular biopsy
    • Schalla S., Bekkers S.C., Dennert R., van Suylen R.J., Waltenberger J., Leiner T., et al. Replacement and reactive myocardial fibrosis in idiopathic dilated cardiomyopathy: comparison of magnetic resonance imaging with right ventricular biopsy. Eur. J. Heart Fail. 2010, 12:227-231.
    • (2010) Eur. J. Heart Fail. , vol.12 , pp. 227-231
    • Schalla, S.1    Bekkers, S.C.2    Dennert, R.3    van Suylen, R.J.4    Waltenberger, J.5    Leiner, T.6
  • 116
    • 78751507979 scopus 로고    scopus 로고
    • Molecular mechanisms that control interstitial fibrosis in the pressure-overloaded heart
    • Creemers E.E., Pinto Y.M. Molecular mechanisms that control interstitial fibrosis in the pressure-overloaded heart. Cardiovasc. Res. 2011, 89:265-272.
    • (2011) Cardiovasc. Res. , vol.89 , pp. 265-272
    • Creemers, E.E.1    Pinto, Y.M.2
  • 117
    • 84863585665 scopus 로고    scopus 로고
    • Interactions between cardiac fibrosis spatial pattern and ionic remodeling on electrical wave propagation
    • Comtois P., Nattel S. Interactions between cardiac fibrosis spatial pattern and ionic remodeling on electrical wave propagation. Conf. Proc. IEEE Eng. Med. Biol. Soc. 2011, 2011:4669-4672.
    • (2011) Conf. Proc. IEEE Eng. Med. Biol. Soc. , vol.2011 , pp. 4669-4672
    • Comtois, P.1    Nattel, S.2
  • 118
    • 0035910104 scopus 로고    scopus 로고
    • Activation delay after premature stimulation in chronically diseased human myocardium relates to the architecture of interstitial fibrosis
    • Kawara T., Derksen R., de Groot J.R., Coronel R., Tasseron S., Linnenbank A.C., et al. Activation delay after premature stimulation in chronically diseased human myocardium relates to the architecture of interstitial fibrosis. Circulation 2001, 104:3069-3075.
    • (2001) Circulation , vol.104 , pp. 3069-3075
    • Kawara, T.1    Derksen, R.2    de Groot, J.R.3    Coronel, R.4    Tasseron, S.5    Linnenbank, A.C.6
  • 119
    • 0032996757 scopus 로고    scopus 로고
    • Cardiac fibrosis and inflammation: interaction with hemodynamic and hormonal factors
    • Nicoletti A., Michel J.B. Cardiac fibrosis and inflammation: interaction with hemodynamic and hormonal factors. Cardiovasc. Res. 1999, 41:532-543.
    • (1999) Cardiovasc. Res. , vol.41 , pp. 532-543
    • Nicoletti, A.1    Michel, J.B.2
  • 120
    • 84861812495 scopus 로고    scopus 로고
    • Immunophenotypic alterations in resident immune cells and myocardial fibrosis in the aging rhesus macaque (Macaca mulatta) heart
    • Macri S.C., Bailey C.C., de Oca N.M., Silva N.A., Rosene D.L., Mansfield K.G., et al. Immunophenotypic alterations in resident immune cells and myocardial fibrosis in the aging rhesus macaque (Macaca mulatta) heart. Toxicol. Pathol. 2012, 40:637-646.
    • (2012) Toxicol. Pathol. , vol.40 , pp. 637-646
    • Macri, S.C.1    Bailey, C.C.2    de Oca, N.M.3    Silva, N.A.4    Rosene, D.L.5    Mansfield, K.G.6
  • 121
    • 84868613300 scopus 로고    scopus 로고
    • Coronary perivascular fibrosis is associated with impairment of coronary blood flow in patients with non-ischemic heart failure
    • Dai Z., Aoki T., Fukumoto Y., Shimokawa H. Coronary perivascular fibrosis is associated with impairment of coronary blood flow in patients with non-ischemic heart failure. J. Cardiol. 2012, 60:416-421.
    • (2012) J. Cardiol. , vol.60 , pp. 416-421
    • Dai, Z.1    Aoki, T.2    Fukumoto, Y.3    Shimokawa, H.4
  • 122
    • 0033978052 scopus 로고    scopus 로고
    • Regional myocardial blood flow reserve impairment and metabolic changes suggesting myocardial ischemia in patients with idiopathic dilated cardiomyopathy
    • van den Heuvel A.F., van Veldhuisen D.J., van der Wall E.E., Blanksma P.K., Siebelink H.M., Vaalburg W.M., et al. Regional myocardial blood flow reserve impairment and metabolic changes suggesting myocardial ischemia in patients with idiopathic dilated cardiomyopathy. J. Am. Coll. Cardiol. 2000, 35:19-28.
    • (2000) J. Am. Coll. Cardiol. , vol.35 , pp. 19-28
    • van den Heuvel, A.F.1    van Veldhuisen, D.J.2    van der Wall, E.E.3    Blanksma, P.K.4    Siebelink, H.M.5    Vaalburg, W.M.6
  • 123
    • 0036272927 scopus 로고    scopus 로고
    • Myocardial stiffness is determined by ventricular fibrosis, but not by compensatory or excessive hypertrophy in hypertensive heart
    • Yamamoto K., Masuyama T., Sakata Y., Nishikawa N., Mano T., Yoshida J., et al. Myocardial stiffness is determined by ventricular fibrosis, but not by compensatory or excessive hypertrophy in hypertensive heart. Cardiovasc. Res. 2002, 55:76-82.
    • (2002) Cardiovasc. Res. , vol.55 , pp. 76-82
    • Yamamoto, K.1    Masuyama, T.2    Sakata, Y.3    Nishikawa, N.4    Mano, T.5    Yoshida, J.6
  • 124
    • 33847105538 scopus 로고    scopus 로고
    • Diastolic heart failure: evidence of increased myocardial collagen turnover linked to diastolic dysfunction
    • Martos R., Baugh J., Ledwidge M., O'Loughlin C., Conlon C., Patle A., et al. Diastolic heart failure: evidence of increased myocardial collagen turnover linked to diastolic dysfunction. Circulation 2007, 115:888-895.
    • (2007) Circulation , vol.115 , pp. 888-895
    • Martos, R.1    Baugh, J.2    Ledwidge, M.3    O'Loughlin, C.4    Conlon, C.5    Patle, A.6
  • 125
    • 16344385466 scopus 로고    scopus 로고
    • Age-dependent changes in myocardial matrix metalloproteinase/tissue inhibitor of metalloproteinase profiles and fibroblast function
    • Lindsey M.L., Goshorn D.K., Squires C.E., Escobar G.P., Hendrick J.W., Mingoia J.T., et al. Age-dependent changes in myocardial matrix metalloproteinase/tissue inhibitor of metalloproteinase profiles and fibroblast function. Cardiovasc. Res. 2005, 66:410-419.
    • (2005) Cardiovasc. Res. , vol.66 , pp. 410-419
    • Lindsey, M.L.1    Goshorn, D.K.2    Squires, C.E.3    Escobar, G.P.4    Hendrick, J.W.5    Mingoia, J.T.6
  • 126
    • 0030924233 scopus 로고    scopus 로고
    • Differential regulation of matrix metalloproteinases associated with aging and hypertension in the rat heart
    • Robert V., Besse S., Sabri A., Silvestre J.S., Assayag P., Nguyen V.T., et al. Differential regulation of matrix metalloproteinases associated with aging and hypertension in the rat heart. Lab. Investig. 1997, 76:729-738.
    • (1997) Lab. Investig. , vol.76 , pp. 729-738
    • Robert, V.1    Besse, S.2    Sabri, A.3    Silvestre, J.S.4    Assayag, P.5    Nguyen, V.T.6
  • 127
    • 31344458952 scopus 로고    scopus 로고
    • Structure and function of matrix metalloproteinases and TIMPs
    • Nagase H., Visse R., Murphy G. Structure and function of matrix metalloproteinases and TIMPs. Cardiovasc. Res. 2006, 69:562-573.
    • (2006) Cardiovasc. Res. , vol.69 , pp. 562-573
    • Nagase, H.1    Visse, R.2    Murphy, G.3
  • 128
    • 84953433030 scopus 로고    scopus 로고
    • Matrix metalloproteinases as input and output signals for post-myocardial infarction remodeling
    • (in this issue)
    • Lindsey M.L., Iyer R.P., Jung M., DeLeon-Pennell K., Ma Y. Matrix metalloproteinases as input and output signals for post-myocardial infarction remodeling. J. Mol. Cell. Cardiol. 2016, 91:134-140. (in this issue).
    • (2016) J. Mol. Cell. Cardiol. , vol.91 , pp. 134-140
    • Lindsey, M.L.1    Iyer, R.P.2    Jung, M.3    DeLeon-Pennell, K.4    Ma, Y.5
  • 129
    • 84894363753 scopus 로고    scopus 로고
    • Diverse functions of matrix metalloproteinases during fibrosis
    • Giannandrea M., Parks W.C. Diverse functions of matrix metalloproteinases during fibrosis. Dis. Model. Mech. 2014, 7:193-203.
    • (2014) Dis. Model. Mech. , vol.7 , pp. 193-203
    • Giannandrea, M.1    Parks, W.C.2
  • 130
    • 34548515108 scopus 로고    scopus 로고
    • Effects of age on plasma matrix metalloproteinases (MMPs) and tissue inhibitor of metalloproteinases (TIMPs)
    • Bonnema D.D., Webb C.S., Pennington W.R., Stroud R.E., Leonardi A.E., Clark L.L., et al. Effects of age on plasma matrix metalloproteinases (MMPs) and tissue inhibitor of metalloproteinases (TIMPs). J. Card. Fail. 2007, 13:530-540.
    • (2007) J. Card. Fail. , vol.13 , pp. 530-540
    • Bonnema, D.D.1    Webb, C.S.2    Pennington, W.R.3    Stroud, R.E.4    Leonardi, A.E.5    Clark, L.L.6
  • 131
    • 0034650486 scopus 로고    scopus 로고
    • Cell surface-localized matrix metalloproteinase-9 proteolytically activates TGF-beta and promotes tumor invasion and angiogenesis
    • Yu Q., Stamenkovic I. Cell surface-localized matrix metalloproteinase-9 proteolytically activates TGF-beta and promotes tumor invasion and angiogenesis. Genes Dev. 2000, 14:163-176.
    • (2000) Genes Dev. , vol.14 , pp. 163-176
    • Yu, Q.1    Stamenkovic, I.2
  • 132
    • 80052727564 scopus 로고    scopus 로고
    • Multi-analyte profiling reveals matrix metalloproteinase-9 and monocyte chemotactic protein-1 as plasma biomarkers of cardiac aging
    • Chiao Y.A., Dai Q., Zhang J., Lin J., Lopez E.F., Ahuja S.S., et al. Multi-analyte profiling reveals matrix metalloproteinase-9 and monocyte chemotactic protein-1 as plasma biomarkers of cardiac aging. Circ. Cardiovasc. Genet. 2011, 4:455-462.
    • (2011) Circ. Cardiovasc. Genet. , vol.4 , pp. 455-462
    • Chiao, Y.A.1    Dai, Q.2    Zhang, J.3    Lin, J.4    Lopez, E.F.5    Ahuja, S.S.6
  • 133
    • 77749298782 scopus 로고    scopus 로고
    • Cardiac-restricted overexpression of membrane type-1 matrix metalloproteinase in mice: effects on myocardial remodeling with aging
    • Spinale F.G., Escobar G.P., Mukherjee R., Zavadzkas J.A., Saunders S.M., Jeffords L.B., et al. Cardiac-restricted overexpression of membrane type-1 matrix metalloproteinase in mice: effects on myocardial remodeling with aging. Circ. Heart Fail. 2009, 2:351-360.
    • (2009) Circ. Heart Fail. , vol.2 , pp. 351-360
    • Spinale, F.G.1    Escobar, G.P.2    Mukherjee, R.3    Zavadzkas, J.A.4    Saunders, S.M.5    Jeffords, L.B.6
  • 134
    • 41149107026 scopus 로고    scopus 로고
    • Aging-related defects are associated with adverse cardiac remodeling in a mouse model of reperfused myocardial infarction
    • Bujak M., Kweon H.J., Chatila K., Li N., Taffet G., Frangogiannis N.G. Aging-related defects are associated with adverse cardiac remodeling in a mouse model of reperfused myocardial infarction. J. Am. Coll. Cardiol. 2008, 51:1384-1392.
    • (2008) J. Am. Coll. Cardiol. , vol.51 , pp. 1384-1392
    • Bujak, M.1    Kweon, H.J.2    Chatila, K.3    Li, N.4    Taffet, G.5    Frangogiannis, N.G.6
  • 135
    • 59449106597 scopus 로고    scopus 로고
    • Role of healing-specific-matricellular proteins and matrix metalloproteinases in age-related enhanced early remodeling after reperfused STEMI in dogs
    • Jugdutt B.I., Palaniyappan A., Uwiera R.R., Idikio H. Role of healing-specific-matricellular proteins and matrix metalloproteinases in age-related enhanced early remodeling after reperfused STEMI in dogs. Mol. Cell. Biochem. 2009, 322:25-36.
    • (2009) Mol. Cell. Biochem. , vol.322 , pp. 25-36
    • Jugdutt, B.I.1    Palaniyappan, A.2    Uwiera, R.R.3    Idikio, H.4
  • 137
    • 33750691072 scopus 로고    scopus 로고
    • Left ventricular function and remodeling after myocardial infarction in aging rats
    • Raya T.E., Gaballa M., Anderson P., Goldman S. Left ventricular function and remodeling after myocardial infarction in aging rats. Am. J. Physiol. Heart Circ. Physiol. 1997, 273. (H2652-H8).
    • (1997) Am. J. Physiol. Heart Circ. Physiol. , vol.273 , pp. H2652-H2658
    • Raya, T.E.1    Gaballa, M.2    Anderson, P.3    Goldman, S.4
  • 138
    • 84856259347 scopus 로고    scopus 로고
    • Targeting fibrosis for the treatment of heart failure: a role for transforming growth factor-beta
    • Edgley A.J., Krum H., Kelly D.J. Targeting fibrosis for the treatment of heart failure: a role for transforming growth factor-beta. Cardiovasc. Ther. 2012, 30:e30-e40.
    • (2012) Cardiovasc. Ther. , vol.30 , pp. e30-e40
    • Edgley, A.J.1    Krum, H.2    Kelly, D.J.3
  • 139
    • 80052819014 scopus 로고    scopus 로고
    • Transforming growth factor (TGF)-beta signaling in cardiac remodeling
    • Dobaczewski M., Chen W., Frangogiannis N.G. Transforming growth factor (TGF)-beta signaling in cardiac remodeling. J. Mol. Cell. Cardiol. 2011, 51:600-606.
    • (2011) J. Mol. Cell. Cardiol. , vol.51 , pp. 600-606
    • Dobaczewski, M.1    Chen, W.2    Frangogiannis, N.G.3
  • 140
    • 84945436604 scopus 로고    scopus 로고
    • Combined angiotensin receptor/neprilysin inhibitors: a review of the new paradigm in the management of chronic heart failure
    • Macdonald P.S. Combined angiotensin receptor/neprilysin inhibitors: a review of the new paradigm in the management of chronic heart failure. Clin. Ther. 2015.
    • (2015) Clin. Ther.
    • Macdonald, P.S.1
  • 141
    • 84879243732 scopus 로고    scopus 로고
    • Renin-angiotensin blockade combined with natriuretic peptide system augmentation: novel therapeutic concepts to combat heart failure
    • von Lueder T.G., Sangaralingham S.J., Wang B.H., Kompa A.R., Atar D., Burnett J.C., et al. Renin-angiotensin blockade combined with natriuretic peptide system augmentation: novel therapeutic concepts to combat heart failure. Circ. Heart Fail. 2013, 6:594-605.
    • (2013) Circ. Heart Fail. , vol.6 , pp. 594-605
    • von Lueder, T.G.1    Sangaralingham, S.J.2    Wang, B.H.3    Kompa, A.R.4    Atar, D.5    Burnett, J.C.6
  • 142
    • 84880159174 scopus 로고    scopus 로고
    • Targeting the renin-angiotensin-aldosterone system in heart failure
    • Lang C.C., Struthers A.D. Targeting the renin-angiotensin-aldosterone system in heart failure. Nat. Rev. Cardiol. 2013, 10:125-134.
    • (2013) Nat. Rev. Cardiol. , vol.10 , pp. 125-134
    • Lang, C.C.1    Struthers, A.D.2
  • 144
    • 84871986523 scopus 로고    scopus 로고
    • Serelaxin, recombinant human relaxin-2, for treatment of acute heart failure (RELAX-AHF): a randomised, placebo-controlled trial
    • Teerlink J.R., Cotter G., Davison B.A., Felker G.M., Filippatos G., Greenberg B.H., et al. Serelaxin, recombinant human relaxin-2, for treatment of acute heart failure (RELAX-AHF): a randomised, placebo-controlled trial. Lancet 2013, 381:29-39.
    • (2013) Lancet , vol.381 , pp. 29-39
    • Teerlink, J.R.1    Cotter, G.2    Davison, B.A.3    Felker, G.M.4    Filippatos, G.5    Greenberg, B.H.6
  • 145
    • 84898544373 scopus 로고    scopus 로고
    • Serelaxin in acute heart failure patients with preserved left ventricular ejection fraction: results from the RELAX-AHF trial
    • Filippatos G., Teerlink J.R., Farmakis D., Cotter G., Davison B.A., Felker G.M., et al. Serelaxin in acute heart failure patients with preserved left ventricular ejection fraction: results from the RELAX-AHF trial. Eur. Heart J. 2014, 35:1041-1050.
    • (2014) Eur. Heart J. , vol.35 , pp. 1041-1050
    • Filippatos, G.1    Teerlink, J.R.2    Farmakis, D.3    Cotter, G.4    Davison, B.A.5    Felker, G.M.6
  • 146
    • 0030453783 scopus 로고    scopus 로고
    • Relaxin induces an extracellular matrix-degrading phenotype in human lung fibroblasts in vitro and inhibits lung fibrosis in a murine model in vivo
    • Unemori E.N., Pickford L.B., Salles A.L., Piercy C.E., Grove B.H., Erikson M.E., et al. Relaxin induces an extracellular matrix-degrading phenotype in human lung fibroblasts in vitro and inhibits lung fibrosis in a murine model in vivo. J. Clin. Invest. 1996, 98:2739-2745.
    • (1996) J. Clin. Invest. , vol.98 , pp. 2739-2745
    • Unemori, E.N.1    Pickford, L.B.2    Salles, A.L.3    Piercy, C.E.4    Grove, B.H.5    Erikson, M.E.6
  • 147
    • 0034829351 scopus 로고    scopus 로고
    • Relaxin inhibits effective collagen deposition by cultured hepatic stellate cells and decreases rat liver fibrosis in vivo
    • Williams E.J., Benyon R.C., Trim N., Hadwin R., Grove B.H., Arthur M.J., et al. Relaxin inhibits effective collagen deposition by cultured hepatic stellate cells and decreases rat liver fibrosis in vivo. Gut 2001, 49:577-583.
    • (2001) Gut , vol.49 , pp. 577-583
    • Williams, E.J.1    Benyon, R.C.2    Trim, N.3    Hadwin, R.4    Grove, B.H.5    Arthur, M.J.6
  • 149
    • 84904514461 scopus 로고    scopus 로고
    • Serelaxin is a more efficacious antifibrotic than enalapril in an experimental model of heart disease
    • Samuel C.S., Bodaragama H., Chew J.Y., Widdop R.E., Royce S.G., Hewitson T.D. Serelaxin is a more efficacious antifibrotic than enalapril in an experimental model of heart disease. Hypertension 2014, 64:315-322.
    • (2014) Hypertension , vol.64 , pp. 315-322
    • Samuel, C.S.1    Bodaragama, H.2    Chew, J.Y.3    Widdop, R.E.4    Royce, S.G.5    Hewitson, T.D.6
  • 150
    • 84880771641 scopus 로고    scopus 로고
    • Relaxin suppresses atrial fibrillation by reversing fibrosis and myocyte hypertrophy, and increasing conduction velocity and sodium current in spontaneously hypertensive rat hearts
    • Parikh A., Patel D.R., CF M.T., Xiang W., Haney J., Yang L., et al. Relaxin suppresses atrial fibrillation by reversing fibrosis and myocyte hypertrophy, and increasing conduction velocity and sodium current in spontaneously hypertensive rat hearts. Circ. Res. 2013.
    • (2013) Circ. Res.
    • Parikh, A.1    Patel, D.R.2    Xiang, W.3    Haney, J.4    Yang, L.5
  • 151
    • 4344606223 scopus 로고    scopus 로고
    • Relaxin modulates cardiac fibroblast proliferation, differentiation, and collagen production and reverses cardiac fibrosis in vivo
    • Samuel C.S., Unemori E.N., Mookerjee I., Bathgate R.A., Layfield S.L., Mak J., et al. Relaxin modulates cardiac fibroblast proliferation, differentiation, and collagen production and reverses cardiac fibrosis in vivo. Endocrinology 2004, 145:4125-4133.
    • (2004) Endocrinology , vol.145 , pp. 4125-4133
    • Samuel, C.S.1    Unemori, E.N.2    Mookerjee, I.3    Bathgate, R.A.4    Layfield, S.L.5    Mak, J.6
  • 154
    • 1542343883 scopus 로고    scopus 로고
    • Extracellular functions of galectin-3
    • Ochieng J., Furtak V., Lukyanov P. Extracellular functions of galectin-3. Glycoconj. J. 2004, 19:527-535.
    • (2004) Glycoconj. J. , vol.19 , pp. 527-535
    • Ochieng, J.1    Furtak, V.2    Lukyanov, P.3
  • 155
    • 78650137499 scopus 로고    scopus 로고
    • Matrilysin-1 (MMP7) cleaves galectin-3 and inhibits wound healing in intestinal epithelial cells
    • Puthenedam M., Wu F., Shetye A., Michaels A., Rhee K.J., Kwon J.H. Matrilysin-1 (MMP7) cleaves galectin-3 and inhibits wound healing in intestinal epithelial cells. Inflamm. Bowel Dis. 2011, 17:260-267.
    • (2011) Inflamm. Bowel Dis. , vol.17 , pp. 260-267
    • Puthenedam, M.1    Wu, F.2    Shetye, A.3    Michaels, A.4    Rhee, K.J.5    Kwon, J.H.6
  • 157
    • 84859639923 scopus 로고    scopus 로고
    • Galectin-3 in ambulatory patients with heart failure: results from the HF-ACTION study
    • Felker G.M., Fiuzat M., Shaw L.K., Clare R., Whellan D.J., Bettari L., et al. Galectin-3 in ambulatory patients with heart failure: results from the HF-ACTION study. Circ. Heart Fail. 2012, 5:72-78.
    • (2012) Circ. Heart Fail. , vol.5 , pp. 72-78
    • Felker, G.M.1    Fiuzat, M.2    Shaw, L.K.3    Clare, R.4    Whellan, D.J.5    Bettari, L.6
  • 158
    • 84922956288 scopus 로고    scopus 로고
    • Galectin-3 in patients with heart failure with preserved ejection fraction: results from the Aldo-DHF trial
    • Edelmann F., Holzendorf V., Wachter R., Nolte K., Schmidt A.G., Kraigher-Krainer E., et al. Galectin-3 in patients with heart failure with preserved ejection fraction: results from the Aldo-DHF trial. Eur. J. Heart Fail. 2015, 17:214-223.
    • (2015) Eur. J. Heart Fail. , vol.17 , pp. 214-223
    • Edelmann, F.1    Holzendorf, V.2    Wachter, R.3    Nolte, K.4    Schmidt, A.G.5    Kraigher-Krainer, E.6
  • 159
    • 84901780251 scopus 로고    scopus 로고
    • Elevated plasma galectin-3 is associated with near-term rehospitalization in heart failure: a pooled analysis of 3 clinical trials
    • e4
    • Meijers W.C., Januzzi J.L., de Filippi C., Adourian A.S., Shah S.J., van Veldhuisen D.J., et al. Elevated plasma galectin-3 is associated with near-term rehospitalization in heart failure: a pooled analysis of 3 clinical trials. Am. Heart J. 2014, 167:853-860. e4.
    • (2014) Am. Heart J. , vol.167 , pp. 853-860
    • Meijers, W.C.1    Januzzi, J.L.2    de Filippi, C.3    Adourian, A.S.4    Shah, S.J.5    van Veldhuisen, D.J.6
  • 160
    • 0028351834 scopus 로고
    • Mechanisms of hypertension in transgenic rats expressing the mouse Ren-2 gene
    • Moriguchi A., Brosnihan K.B., Kumagai H., Ganten D., Ferrario C.M. Mechanisms of hypertension in transgenic rats expressing the mouse Ren-2 gene. Am. J. Phys. 1994, 266:R1273-R1279.
    • (1994) Am. J. Phys. , vol.266 , pp. R1273-R1279
    • Moriguchi, A.1    Brosnihan, K.B.2    Kumagai, H.3    Ganten, D.4    Ferrario, C.M.5
  • 161
    • 20844462878 scopus 로고    scopus 로고
    • Galectin-3 marks activated macrophages in failure-prone hypertrophied hearts and contributes to cardiac dysfunction
    • Sharma U.C., Pokharel S., van Brakel T.J., van Berlo J.H., Cleutjens J.P.M., Schroen B., et al. Galectin-3 marks activated macrophages in failure-prone hypertrophied hearts and contributes to cardiac dysfunction. Circulation 2004, 110:3121-3128.
    • (2004) Circulation , vol.110 , pp. 3121-3128
    • Sharma, U.C.1    Pokharel, S.2    van Brakel, T.J.3    van Berlo, J.H.4    Cleutjens, J.P.M.5    Schroen, B.6
  • 164
    • 84940048340 scopus 로고    scopus 로고
    • Serum PINP, PIIINP, galectin-3, and ST2 as surrogates of myocardial fibrosis and echocardiographic left venticular diastolic filling properties
    • Lepojarvi E.S., Piira O.P., Paakko E., Lammentausta E., Risteli J., Miettinen J.A., et al. Serum PINP, PIIINP, galectin-3, and ST2 as surrogates of myocardial fibrosis and echocardiographic left venticular diastolic filling properties. Front. Physiol. 2015, 6:200.
    • (2015) Front. Physiol. , vol.6 , pp. 200
    • Lepojarvi, E.S.1    Piira, O.P.2    Paakko, E.3    Lammentausta, E.4    Risteli, J.5    Miettinen, J.A.6
  • 165
    • 84866729958 scopus 로고    scopus 로고
    • Galectin-3, a marker of cardiac fibrosis, predicts incident heart failure in the community
    • Ho J.E., Liu C., Lyass A., Courchesne P., Pencina M.J., Vasan R.S., et al. Galectin-3, a marker of cardiac fibrosis, predicts incident heart failure in the community. J. Am. Coll. Cardiol. 2012, 60:1249-1256.
    • (2012) J. Am. Coll. Cardiol. , vol.60 , pp. 1249-1256
    • Ho, J.E.1    Liu, C.2    Lyass, A.3    Courchesne, P.4    Pencina, M.J.5    Vasan, R.S.6
  • 167
    • 84876134473 scopus 로고    scopus 로고
    • Galectin-3 is an independent marker for ventricular remodeling and mortality in patients with chronic heart failure
    • Lok D.J., Lok S.I., de la Porte PW B.-A., Badings E., Lipsic E., van Wijngaarden J., et al. Galectin-3 is an independent marker for ventricular remodeling and mortality in patients with chronic heart failure. Clin. Res. Cardiol. 2013, 102:103-110.
    • (2013) Clin. Res. Cardiol. , vol.102 , pp. 103-110
    • Lok, D.J.1    Lok, S.I.2    de la Porte, P.W.B.-A.3    Badings, E.4    Lipsic, E.5    van Wijngaarden, J.6
  • 168
    • 84924912803 scopus 로고    scopus 로고
    • Galectin-3 in heart failure with preserved ejection fraction. A RELAX trial substudy (phosphodiesterase-5 inhibition to improve clinical status and exercise capacity in diastolic heart failure)
    • AbouEzzeddine O.F., Haines P., Stevens S., Nativi-Nicolau J., Felker G.M., Borlaug B.A., et al. Galectin-3 in heart failure with preserved ejection fraction. A RELAX trial substudy (phosphodiesterase-5 inhibition to improve clinical status and exercise capacity in diastolic heart failure). JACC Heart Fail. 2015, 3:245-252.
    • (2015) JACC Heart Fail. , vol.3 , pp. 245-252
    • AbouEzzeddine, O.F.1    Haines, P.2    Stevens, S.3    Nativi-Nicolau, J.4    Felker, G.M.5    Borlaug, B.A.6
  • 169
    • 0033612183 scopus 로고    scopus 로고
    • Mechanical stretch activates the JAK/STAT pathway in rat cardiomyocytes
    • Pan J., Fukuda K., Saito M., Matsuzaki J., Kodama H., Sano M., et al. Mechanical stretch activates the JAK/STAT pathway in rat cardiomyocytes. Circ. Res. 1999, 84:1127-1136.
    • (1999) Circ. Res. , vol.84 , pp. 1127-1136
    • Pan, J.1    Fukuda, K.2    Saito, M.3    Matsuzaki, J.4    Kodama, H.5    Sano, M.6
  • 170
    • 84855280828 scopus 로고    scopus 로고
    • Cardiotrophin-1 plasma levels are increased in patients with diastolic heart failure
    • Celik A., Sahin S., Koc F., Karayakali M., Sahin M., Benli I., et al. Cardiotrophin-1 plasma levels are increased in patients with diastolic heart failure. Med. Sci. Monit. 2012, 18:CR25-CR31.
    • (2012) Med. Sci. Monit. , vol.18 , pp. CR25-CR31
    • Celik, A.1    Sahin, S.2    Koc, F.3    Karayakali, M.4    Sahin, M.5    Benli, I.6
  • 172
    • 0037126017 scopus 로고    scopus 로고
    • Cardiotrophin-1 in heart failure
    • Bristow M.R., Long C.S. Cardiotrophin-1 in heart failure. Circulation 2002, 106:1430-1432.
    • (2002) Circulation , vol.106 , pp. 1430-1432
    • Bristow, M.R.1    Long, C.S.2
  • 173
    • 0031041317 scopus 로고    scopus 로고
    • Cardiotrophin 1 (CT-1) inhibition of cardiac myocyte apoptosis via a mitogen-activated protein kinase-dependent pathway. Divergence from downstream CT-1 signals for myocardial cell hypertrophy
    • Sheng Z., Knowlton K., Chen J., Hoshijima M., Brown J.H., Chien K.R. Cardiotrophin 1 (CT-1) inhibition of cardiac myocyte apoptosis via a mitogen-activated protein kinase-dependent pathway. Divergence from downstream CT-1 signals for myocardial cell hypertrophy. J. Biol. Chem. 1997, 272:5783-5791.
    • (1997) J. Biol. Chem. , vol.272 , pp. 5783-5791
    • Sheng, Z.1    Knowlton, K.2    Chen, J.3    Hoshijima, M.4    Brown, J.H.5    Chien, K.R.6
  • 174
    • 84894466867 scopus 로고    scopus 로고
    • Association of cardiotrophin-1 with myocardial fibrosis in hypertensive patients with heart failure
    • López B., González A., Querejeta R., Larman M., Rábago G., Díez J. Association of cardiotrophin-1 with myocardial fibrosis in hypertensive patients with heart failure. Hypertension 2014, 63:483-489.
    • (2014) Hypertension , vol.63 , pp. 483-489
    • López, B.1    González, A.2    Querejeta, R.3    Larman, M.4    Rábago, G.5    Díez, J.6
  • 175
    • 84871613231 scopus 로고    scopus 로고
    • Absence of cardiotrophin 1 is associated with decreased age-dependent arterial stiffness and increased longevity in mice
    • López-Andrés N., Calvier L., Labat C., Fay R., Díez J., Benetos A., et al. Absence of cardiotrophin 1 is associated with decreased age-dependent arterial stiffness and increased longevity in mice. Hypertension 2013, 61:120-129.
    • (2013) Hypertension , vol.61 , pp. 120-129
    • López-Andrés, N.1    Calvier, L.2    Labat, C.3    Fay, R.4    Díez, J.5    Benetos, A.6
  • 176
    • 84908160751 scopus 로고    scopus 로고
    • Noncoding RNAs and myocardial fibrosis
    • Thum T. Noncoding RNAs and myocardial fibrosis. Nat. Rev. Cardiol. 2014, 11:655-663.
    • (2014) Nat. Rev. Cardiol. , vol.11 , pp. 655-663
    • Thum, T.1
  • 177
    • 4644309196 scopus 로고    scopus 로고
    • The functions of animal microRNAs
    • Ambros V. The functions of animal microRNAs. Nature 2004, 431:350-355.
    • (2004) Nature , vol.431 , pp. 350-355
    • Ambros, V.1
  • 178
    • 84923585184 scopus 로고    scopus 로고
    • MicroRNAs in myocardial infarction
    • Boon R.A., Dimmeler S. MicroRNAs in myocardial infarction. Nat. Rev. Cardiol. 2015, 12:135-142.
    • (2015) Nat. Rev. Cardiol. , vol.12 , pp. 135-142
    • Boon, R.A.1    Dimmeler, S.2
  • 179
    • 84890559977 scopus 로고    scopus 로고
    • The therapeutic potential of miRNAs in cardiac fibrosis: where do we stand?
    • Wijnen W.J., Pinto Y.M., Creemers E.E. The therapeutic potential of miRNAs in cardiac fibrosis: where do we stand?. J. Cardiovasc. Transl. Res. 2013, 6:899-908.
    • (2013) J. Cardiovasc. Transl. Res. , vol.6 , pp. 899-908
    • Wijnen, W.J.1    Pinto, Y.M.2    Creemers, E.E.3
  • 180
    • 84868475728 scopus 로고    scopus 로고
    • MicroRNA therapeutics for cardiovascular disease: opportunities and obstacles
    • van Rooij E., Olson E.N. MicroRNA therapeutics for cardiovascular disease: opportunities and obstacles. Nat. Rev. Drug Discov. 2012, 11:860-872.
    • (2012) Nat. Rev. Drug Discov. , vol.11 , pp. 860-872
    • van Rooij, E.1    Olson, E.N.2
  • 181
    • 84903717510 scopus 로고    scopus 로고
    • Development of microRNA therapeutics is coming of age
    • van Rooij E., Kauppinen S. Development of microRNA therapeutics is coming of age. EMBO Mol. Med. 2014, 6:851-864.
    • (2014) EMBO Mol. Med. , vol.6 , pp. 851-864
    • van Rooij, E.1    Kauppinen, S.2
  • 182
    • 84855244103 scopus 로고    scopus 로고
    • MicroRNA therapeutics in cardiovascular medicine
    • Thum T. MicroRNA therapeutics in cardiovascular medicine. EMBO Mol. Med. 2012, 4:3-14.
    • (2012) EMBO Mol. Med. , vol.4 , pp. 3-14
    • Thum, T.1
  • 183
    • 84879134613 scopus 로고    scopus 로고
    • MicroRNA-22 increases senescence and activates cardiac fibroblasts in the aging heart
    • Jazbutyte V., Fiedler J., Kneitz S., Galuppo P., Just A., Holzmann A., et al. MicroRNA-22 increases senescence and activates cardiac fibroblasts in the aging heart. Age 2013, 35:747-762.
    • (2013) Age , vol.35 , pp. 747-762
    • Jazbutyte, V.1    Fiedler, J.2    Kneitz, S.3    Galuppo, P.4    Just, A.5    Holzmann, A.6
  • 185
    • 84946616107 scopus 로고    scopus 로고
    • MicroRNA-34a induces vascular smooth muscle cells senescence by SIRT1 downregulation and promotes the expression of age-associated pro-inflammatory secretory factors
    • Badi I., Burba I., Ruggeri C., Zeni F., Bertolotti M., Scopece A., et al. MicroRNA-34a induces vascular smooth muscle cells senescence by SIRT1 downregulation and promotes the expression of age-associated pro-inflammatory secretory factors. J. Gerontol. A Biol. Sci. Med. Sci. 2014.
    • (2014) J. Gerontol. A Biol. Sci. Med. Sci.
    • Badi, I.1    Burba, I.2    Ruggeri, C.3    Zeni, F.4    Bertolotti, M.5    Scopece, A.6
  • 187
    • 84921418393 scopus 로고    scopus 로고
    • The microRNA miR-17-3p inhibits mouse cardiac fibroblast senescence by targeting Par4
    • Du W.W., Li X., Li T., Li H., Khorshidi A., Liu F., et al. The microRNA miR-17-3p inhibits mouse cardiac fibroblast senescence by targeting Par4. J. Cell Sci. 2015, 128:293-304.
    • (2015) J. Cell Sci. , vol.128 , pp. 293-304
    • Du, W.W.1    Li, X.2    Li, T.3    Li, H.4    Khorshidi, A.5    Liu, F.6
  • 189
    • 77955711212 scopus 로고    scopus 로고
    • Role of osteopontin in heart failure associated with aging
    • Singh M., Foster C.R., Dalal S., Singh K. Role of osteopontin in heart failure associated with aging. Heart Fail. Rev. 2010, 15:487-494.
    • (2010) Heart Fail. Rev. , vol.15 , pp. 487-494
    • Singh, M.1    Foster, C.R.2    Dalal, S.3    Singh, K.4
  • 190
    • 84860145209 scopus 로고    scopus 로고
    • Matricellular proteins in cardiac adaptation and disease
    • Frangogiannis N.G. Matricellular proteins in cardiac adaptation and disease. Physiol. Rev. 2012, 92:635-688.
    • (2012) Physiol. Rev. , vol.92 , pp. 635-688
    • Frangogiannis, N.G.1
  • 191
  • 192
    • 0035947750 scopus 로고    scopus 로고
    • Exaggerated left ventricular dilation and reduced collagen deposition after myocardial infarction in mice lacking osteopontin
    • Trueblood N.A., Xie Z., Communal C., Sam F., Ngoy S., Liaw L., et al. Exaggerated left ventricular dilation and reduced collagen deposition after myocardial infarction in mice lacking osteopontin. Circ. Res. 2001, 88:1080-1087.
    • (2001) Circ. Res. , vol.88 , pp. 1080-1087
    • Trueblood, N.A.1    Xie, Z.2    Communal, C.3    Sam, F.4    Ngoy, S.5    Liaw, L.6
  • 193
    • 84890085360 scopus 로고    scopus 로고
    • Diagnostic and prognostic value of osteopontin in patients with acute congestive heart failure
    • Behnes M., Brueckmann M., Lang S., Espeter F., Weiss C., Neumaier M., et al. Diagnostic and prognostic value of osteopontin in patients with acute congestive heart failure. Eur. J. Heart Fail. 2013, 15:1390-1400.
    • (2013) Eur. J. Heart Fail. , vol.15 , pp. 1390-1400
    • Behnes, M.1    Brueckmann, M.2    Lang, S.3    Espeter, F.4    Weiss, C.5    Neumaier, M.6
  • 196
    • 84940172573 scopus 로고    scopus 로고
    • Osteopontin is indispensible for AP1-mediated angiotensin II-related miR-21 transcription during cardiac fibrosis
    • Lorenzen J.M., Schauerte C., Hubner A., Kolling M., Martino F., Scherf K., et al. Osteopontin is indispensible for AP1-mediated angiotensin II-related miR-21 transcription during cardiac fibrosis. Eur. Heart J. 2015, 36:2184-2196.
    • (2015) Eur. Heart J. , vol.36 , pp. 2184-2196
    • Lorenzen, J.M.1    Schauerte, C.2    Hubner, A.3    Kolling, M.4    Martino, F.5    Scherf, K.6
  • 197
    • 57749168828 scopus 로고    scopus 로고
    • MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts
    • Thum T., Gross C., Fiedler J., Fischer T., Kissler S., Bussen M., et al. MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts. Nature 2008, 456:980-984.
    • (2008) Nature , vol.456 , pp. 980-984
    • Thum, T.1    Gross, C.2    Fiedler, J.3    Fischer, T.4    Kissler, S.5    Bussen, M.6
  • 198
    • 84856695092 scopus 로고    scopus 로고
    • PAI-1-regulated miR-21 defines a novel age-associated fibrogenic pathway in muscular dystrophy
    • Ardite E., Perdiguero E., Vidal B., Gutarra S., Serrano A.L., Munoz-Canoves P. PAI-1-regulated miR-21 defines a novel age-associated fibrogenic pathway in muscular dystrophy. J. Cell Biol. 2012, 196:163-175.
    • (2012) J. Cell Biol. , vol.196 , pp. 163-175
    • Ardite, E.1    Perdiguero, E.2    Vidal, B.3    Gutarra, S.4    Serrano, A.L.5    Munoz-Canoves, P.6
  • 199
    • 0025302162 scopus 로고
    • Relaxin modulates synthesis and secretion of procollagenase and collagen by human dermal fibroblasts
    • Unemori E.N., Amento E.P. Relaxin modulates synthesis and secretion of procollagenase and collagen by human dermal fibroblasts. J. Biol. Chem. 1990, 265:10681-10685.
    • (1990) J. Biol. Chem. , vol.265 , pp. 10681-10685
    • Unemori, E.N.1    Amento, E.P.2
  • 200
    • 84873622349 scopus 로고    scopus 로고
    • Genetic and pharmacological inhibition of galectin-3 prevents cardiac remodeling by interfering with myocardial fibrogenesis
    • Yu L., Ruifrok W.P.T., Meissner M., Bos E.M., van Goor H., Sanjabi B., et al. Genetic and pharmacological inhibition of galectin-3 prevents cardiac remodeling by interfering with myocardial fibrogenesis. Circ. Heart Fail. 2013, 6:107-117.
    • (2013) Circ. Heart Fail. , vol.6 , pp. 107-117
    • Yu, L.1    Ruifrok, W.P.T.2    Meissner, M.3    Bos, E.M.4    van Goor, H.5    Sanjabi, B.6
  • 201
    • 84864278283 scopus 로고    scopus 로고
    • Cardiotrophin 1 is involved in cardiac, vascular, and renal fibrosis and dysfunction
    • Lopez-Andres N., Rousseau A., Akhtar R., Calvier L., Inigo C., Labat C., et al. Cardiotrophin 1 is involved in cardiac, vascular, and renal fibrosis and dysfunction. Hypertension 2012, 60:563-573.
    • (2012) Hypertension , vol.60 , pp. 563-573
    • Lopez-Andres, N.1    Rousseau, A.2    Akhtar, R.3    Calvier, L.4    Inigo, C.5    Labat, C.6


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