Integrins: Implications for aging in heart failure therapy

Aging and Heart Failure: Mechanisms and Management

Volumn , Issue , 2014, Pages 401-410

  Daniel, Laura L ^a   Joyner, William L ^a   Singh, Mahipal ^a   Singh, Krishna ^a  

^a East Tennessee State University   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84909647120     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1007/978-1-4939-0268-2     Document Type: Chapter

References (77)

1. Hynes R. Integrins: a family of cell surface receptors. Cell. 1987;48:549-54.
2. Lowell C, Mayadas T. Overview: studying integrins in vivo. Methods Mol Biol. 2012;757:369-97.
3. Ross R, Borg T. Integrins and the myocardium. Circ Res. 2001;88:1112-21.
4. Hynes R. Integrins: bidirectional, allosteric signaling machines. Cell. 2002;110:673-87.
5. Humphries M. Integrin structure. Biochem Soc Trans. 2000;28:311-39.
6. Campbell I, Humphries M. Integrin structure, activation, and interactions. Cold Spring Harb Perspect Biol. 2011;3:a004994.
7. Meighan C, Schwarzbauer J. Temporal and spatial regulation of integrins during development. Curr Opin Cell Biol. 2008;20:520-4.
8. Wu M, Fannin J, Rice K, Wang B, Blough E. Effect of aging on cellular mechanotransduction. Ageing Res Rev. 2011;10:1-15.
9. Zamir E, Geiger B. Molecular complexity and dynamics of cell-matrix adhesions. J Cell Sci. 2001;114:3583-90.
10. Wozniak M, Modzelewska K, Kwong L, Keely P. Focal adhesion regulation of cell behavior. Biochim Biophys Acta. 2004;1692:103-19.
11. Galbraith C, Yamada K, Sheetz M. The relationship between force and focal complex development. J Cell Biol. 2002;159:695-705.
12. DePasquale J, Izzard C. Accumulation of talin in nodes at the edge of the lamellipodium and separate incorporation into adhesion plaques at focal contacts in fibroblasts. J Cell Biol. 1991;113:1351-9.
13. Laudanna C, Kim J, Constantin G, Butcher E. Rapid leukocyte integrin activation by chemokines. Immunol Rev. 2002;186:37-46.
14. Calderwood D. Talin controls integrin activation. Biochem Soc Trans. 2004;32:434-7.
15. Ross R. Molecular and mechanical synergy: crosstalk between integrins and growth factor receptors. Cardiovasc Res. 2004;63:381-90.
16. Munger J, Sheppard D. Cross talk among TGF-Beta signaling pathways, integrins, and the extracellular matrix. Cold Spring Harb Perspect Biol. 2011; 3:a005017.
17. Nagai T, Laser M, Baicu C, Zile M, Cooper G, Kuppuswamy D. Beta3-integrin-mediated focal adhesion complex formation: adult cardiocytes embedded in three-dimensional polymer matrices. Am J Cardiol. 1999;83:38H-43.
18. van der Flier A, Kuikman I, Baudoin C, van der Neut R, Sonnenberg A. A novel beta 1 integrin isoform produced by alternative splicing: unique expression in cardiac and skeletal muscle. FEBS Lett. 1995;369: 340-4.
19. Zhidkova N, Belkin A, Mayne R. Novel isoform of beta 1 integrin expressed in skeletal and cardiac muscle. Biochem Biophys Res Commun. 1995;214:279-85.
20. Ross R, Pham C, Shai S, Goldhaber J, Fenczik C, Glembotski C, Ginsberg M, Loftus J. Beta1 integrins participate in the hypertrophic response of rat ventricular myocytes. Circ Res. 1998;82:1160-72.
21. MacKenna D, Summerour S, Villarreal F. Role of mechanical factors in modulating cardiac fibroblast function and extracellular matrix synthesis. Cardiovasc Res. 2000;46:257-63.
22. Harston R, Kuppuswamy D. Integrins are the necessary links to hypertrophic growth in cardiomyocytes. J Signal Transduct. 2011;2011:521-742.
23. Katsumi A, Orr A, Tzima E, Schwartz M. Integrins in mechanotransduction. J Biol Chem. 2004;279: 12001-4.
24. Edgley A, Krum H, Kelly D. Targeting fibrosis for the treatment of heart failure: a role for transforming growth factor-beta. Cardiovasc Ther. 2012;30:e30-40.
25. Dabiri B, Lee H, Parker K. A potential role for integ- rin signaling in mechanoelectrical feedback progress in biophysics and molecular biology. Prog Biophys Mol Biol. 2012;110(2-3):196-203.
26. Burgess M, McCrea J, Hedrick H. Age-associated changes in cardiac matrix and integrins. Mech Ageing Dev. 2001;122:1739-56.
27. Sottile J, Hocking D. Fibronectin polymerization regulates the composition and stability of extracellular matrix fibrils and cell-matrix adhesions. Mol Biol Cell. 2002;13:3546-59.
28. Mamuya W, Chobanian A, Brecher P. Age-related changes in fibronectin expression in spontaneously hypertensive, Wistar-Kyoto, and Wistar rat hearts. Circ Res. 1992;71:1341-50.
29. Wilson CG, Stone JW, Fowlkes V, Morales MO, Murphy CJ, Baxter SC, Goldsmith EC. Age- dependent expression of collagen receptors and deformation of type I collagen substrates by rat cardiac fibroblasts. Microsc Microanal. 2011;17:555-62.
30. Communal C, Huq F, Lebeche D, Mestel C, Gwathmey J, Hajjar R. Decreased efficiency of adenovirus-mediated gene transfer in aging cardiomyocytes. Circulation. 2003;107:1170-5.
31. Swynghedauw B. Molecular mechanisms of myocardial remodeling. Physiol Rev. 1999;79:215-62.
32. Shih H, Lee B, Lee R, Boyle A. The aging heart and post-infarction left ventricular remodeling. J Am Coll Cardiol. 2011;57:9-17.
33. Sun M, Opavsky M, Stewart D, Rabinovitch M, Dawood F, Wen W-H, Liu P. Temporal response and localization of integrins beta1 and beta3 in the heart after myocardial infarction: regulation by cytokines. Circulation. 2003;107:1046-52.
34. Nawata J, Ohno I, Isoyama S, Suzuki J, Miura S, Ikeda J, Shirato K. Differential expression of alpha 1, alpha 3 and alpha 5 integrin subunits in acute and chronic stages of myocardial infarction in rats. Cardiovasc Res. 1999;43:371-81.
35. Bujak M, Kweon H, Chatila K, Li N, Taffet G, Frangogiannis N. Aging-related defects are associated with adverse cardiac remodeling in a mouse model of reperfused myocardial infarction. J Am Coll Cardiol. 2008;51:1384-92.
36. Bujak M, Frangogiannis N. The role of TGF-beta signaling in myocardial infarction and cardiac remodeling. Cardiovasc Res. 2007;74:184-95.
37. Burns J, Issekutz T, Yagita H, Issekutz A. The alpha 4 beta 1 (very late antigen (VLA)-4, CD49d/CD29) and alpha 5 beta 1 (VLA-5, CD49e/CD29) integrins mediate beta 2 (CD11/CD18) integrin-independent neutrophil recruitment to endotoxin-induced lung inflammation. J Immunol. 2001;166:4644-9.
38. Pfister R, Acksteiner C, Baumgarth J, Burst V, Geissler H, Margulies K, Houser S, Bloch W, Flesch M. Loss of beta1D-integrin function in human ischemic cardiomyopathy. Basic Res Cardiol. 2007;102: 257-64.
39. Shai S-Y, Harpf A, Babbitt C, Jordan M, Fishbein M, Chen J, Omura M, Leil T, Becker K, Jiang M, Smith D, Cherry S, Loftus J, Ross R. Cardiac myocyte- specific excision of the beta1 integrin gene results in myocardial fibrosis and cardiac failure. Circ Res. 2002;90:458-64.
40. Krishnamurthy P, Subramanian V, Singh M, Singh K. Deficiency of beta1 integrins results in increased myocardial dysfunction after myocardial infarction. Heart (British Cardiac Society). 2006;92:1309-15.
41. Calderwood D. Integrin activation. J Cell Sci. 2004;117:657-66.
42. Ding B, Price R, Goldsmith E, Borg T, Yan X, Douglas P, Weinberg E, Bartunek J, Thielen T, Didenko V, Lorell B. Left ventricular hypertrophy in ascending aortic stenosis mice: anoikis and the progression to early failure. Circulation. 2000;101:2854-62.
43. Hooper N, Karran E, Turner A. Membrane protein secretases. Biochem J. 1997;321(Pt 2):265-79.
44. Manso A, Elsherif L, Kang S-M, Ross R. Integrins, membrane-type matrix metalloproteinases and ADAMs: potential implications for cardiac remodeling. Cardiovasc Res. 2006;69:574-84.
45. Eckhouse S, Spinale F. Changes in the myocardial interstitium and contribution to the progression of heart failure. Heart Fail Clin. 2012;8:7-20.
46. Li J, Du W, Jiang S, Tian H. Expression of ADAM-15 in rat myocardial infarction. Int J Exp Pathol. 2009; 90:347-54.
47. Olivetti G, Melissari M, Capasso J, Anversa P. Cardiomyopathy of the aging human heart. Myocyte loss and reactive cellular hypertrophy. Circ Res. 1991;68:1560-8.
48. Goldsmith E, Carver W, McFadden A, Goldsmith J, Price R, Sussman M, Lorell B, Cooper G, Borg T. Integrin shedding as a mechanism of cellular adaptation during cardiac growth. Am J Physiol Heart Circ Physiol. 2003;284:H2227-34.
49. Menon B, Krishnamurthy P, Kaverina E, Johnson J, Ross R, Singh M, Singh K. Expression of the cytoplasmic domain of beta1 integrin induces apoptosis in adult rat ventricular myocytes (ARVM) via the involvement of caspase-8 and mitochondrial death pathway. Basic Res Cardiol. 2006;101:485-93.
50. van Empel V, Bertrand A, Hofstra L, Crijns H, Doevendans P, De Windt L. Myocyte apoptosis in heart failure. Cardiovasc Res. 2005;67:21-9.
51. Chen L, Knowlton AA. Mitochondrial dynamics in heart failure. Congest Heart Fail. 2011;17:257-61.
52. Sheydina A, Riordon DR, Boheler KR. Molecular mechanisms of cardiomyocyte aging. Clin Sci (Lond). 2011;121:315-29.
53. Hasking G, Esler M, Jennings G, Burton D, Johns J, Korner P. Norepinephrine spillover to plasma in patients with congestive heart failure: evidence of increased overall and cardiorenal sympathetic nervous activity. Circulation. 1986;73:615-21.
54. Karlsberg R, Penkoske P, Cryer P, Corr P, Roberts R. Rapid activation of the sympathetic nervous system following coronary artery occlusion: relationship to infarct size, site, and haemodynamic impact. Cardiovasc Res. 1979;13:523-31.
55. Graham L, Smith P, Stoker J, Mackintosh A, Mary D. Time course of sympathetic neural hyperactivity after uncomplicated acute myocardial infarction. Circulation. 2002;106:793-7.
56. Margiocco M, Borgarelli M, Musch T, Hirai D, Hageman K, Fels R, Garcia A, Kenney M. Effects of combined aging and heart failure on visceral sympathetic nerve and cardiovascular responses to progressive hyperthermia in F344 rats. Am J Physiol Regul Integr Comp Physiol. 2010;299:R1555-63.
57. Amin P, Singh M, Singh K. Beta-adrenergic receptor- stimulated cardiac myocyte apoptosis: role of betal integrins. J Sig Transduct. 2011;2011:179057.
58. Daaka Y, Luttrell L, Lefkowitz R. Switching of the coupling of the beta2-adrenergic receptor to different G proteins by protein kinase A. Nature. 1997; 390:88-91.
59. Nikolaev V, Moshkov A, Lyon A, Miragoli M, Novak P, Paur H, Lohse M, Korchev Y, Harding S, Gorelik J. Beta2-adrenergic receptor redistribution in heart failure changes cAMP compartmentation. Science (New York, NY). 2010;327:1653-7.
60. Communal C, Singh M, Menon B, Xie Z, Colucci W, Singh K. Beta1 integrins expression in adult rat ventricular myocytes and its role in the regulation of beta-adrenergic receptor-stimulated apoptosis. J Cell Biochem. 2003;89:381-8.
61. Krishnamurthy P, Subramanian V, Singh M, Singh K. Beta1 integrins modulate beta-adrenergic receptor- stimulated cardiac myocyte apoptosis and myocardial remodeling. Hypertension. 2007;49:865-72.
62. Menon B, Singh M, Singh K. Matrix metalloproteinases mediate beta-adrenergic receptor-stimulated apoptosis in adult rat ventricular myocytes. Am J Physiol Cell Physiol. 2005;289:C168-76.
63. Menon B, Singh M, Ross R, Johnson J, Singh K. Beta-adrenergic receptor-stimulated apoptosis in adult cardiac myocytes involves MMP-2-mediated disruption of beta1 integrin signaling and mitochondrial pathway. Am J Physiol Cell Physiol. 2006; 290:C254-61.
64. Boyle A, Shih H, Hwang J, Ye J, Lee B, Zhang Y, Kwon D, Jun K, Zheng D, Sievers R, Angeli F, Yeghiazarians Y, Lee R. Cardiomyopathy of aging in the mammalian heart is characterized by myocardial hypertrophy, fibrosis and a predisposition towards cardiomyocyte apoptosis and autophagy. Exp Gerontol. 2011;46:549-59.
65. Frey N, Olson E. Cardiac hypertrophy: the good, the bad, and the ugly. Annu Rev Physiol. 2003;65:45-79.
66. Terracio L, Rubin K, Gullberg D, Balog E, Carver W, Jyring R, Borg T. Expression of collagen binding inte- grins during cardiac development and hypertrophy. Circ Res. 1991;68:734-44.
67. Burgess M, Terracio L, Hirozane T, Borg T. Differential integrin expression by cardiac fibroblasts from hypertensive and exercise-trained rat hearts. Cardiovasc Pathol. 2002;11:78-87.
68. Willey C, Balasubramanian S, Rodriguez Rosas MC, Ross R, Kuppuswamy D. Focal complex formation in adult cardiomyocytes is accompanied by the activation of beta3 integrin and c-Src. J Mol Cell Cardiol. 2003;35:671-83.
69. Ren J, Avery J, Zhao H, Schneider J, Ross F, Muslin A. Beta3 integrin deficiency promotes cardiac hypertrophy and inflammation. J Mol Cell Cardiol. 2007;42:367-77.
70. Johnston RK, Balasubramanian S, Kasiganesan H, Baicu CF, Zile MR, Kuppuswamy D. Beta3 integrin- mediated ubiquitination activates survival signaling during myocardial hypertrophy. FASEB J. 2009;23: 2759-71.
71. Konstam M, Kramer D, Patel A, Maron M, Udelson J. Left ventricular remodeling in heart failure: current concepts in clinical significance and assessment. JACC Cardiovasc Imaging. 2011;4:98-108.
72. Mathew J, Sleight P, Lonn E, Johnstone D, Pogue J, Yi Q, Bosch J, Sussex B, Probstfield J, Yusuf S. Heart outcomes prevention evaluation I. Reduction of cardiovascular risk by regression of electrocardiographic markers of left ventricular hypertrophy by the angiotensin-converting enzyme inhibitor ramipril. Circulation. 2001;104:1615-21.
73. Kawano H, Cody R, Graf K, Goetze S, Kawano Y, Schnee J, Law R, Hsueh W. Angiotensin II enhances integrin and alpha-actinin expression in adult rat cardiac fibroblasts. Hypertension. 2000;35:273-9.
74. Brooks W, Conrad C. Myocardial fibrosis in transforming growth factor beta(1)heterozygous mice. J Mol Cell Cardiol. 2000;32:187-95.
75. Aluwihare P, Mu Z, Zhao Z, Yu D, Weinreb P, Horan G, Violette S, Munger J. Mice that lack activity of alphavbeta6- and alphavbeta8-integrins reproduce the abnormalities of Tgf-beta1 and Tgf-beta3 null mice. J Cell Sci. 2009;122:227-32.
76. Schmidt U, del Monte F, Miyamoto M, Matsui T, Gwathmey J, Rosenzweig A, Hajjar R. Restoration of diastolic function in senescent rat hearts through adenoviral gene transfer of sarcoplasmic reticulum Ca(2+)-ATPase. Circulation. 2000;101:790-6.
77. Sherif H, Saraste A, Nekolla S, Weidl E, Reder S, Tapfer A, Rudelius M, Higuchi T, Botnar R, Wester HJ, Schwaiger M. Molecular imaging of early alphav beta3 integrin expression predicts long-term left- ventricle remodeling after myocardial infarction in rats. J Nucl Med. 2012;53:318-23.