Elastin stabilizes an infarct and preserves ventricular function

Circulation

Volumn 112, Issue 9 SUPPL., 2005, Pages

  Mizuno, Tomohiro ^a   Yau, Terrence M ^a   Weisel, Richard D ^a   Kiani, Chris G ^a   Li, Ren Ke ^a,b  

^a UNIVERSITY OF TORONTO   (Canada)

^b TORONTO GENERAL HOSPITAL   (Canada)

Author keywords

Cells; Genes; Myocardial infarction; Remodeling; Transplantation

Indexed keywords

ELASTIN; RECOMBINANT ELASTIN; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG;

ADOLESCENT; ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL BASED GENE THERAPY; CONTROLLED STUDY; CORONARY ARTERY LIGATION; DRUG EFFECT; ECHOCARDIOGRAPHY; ELASTIC FIBER; ELASTICITY; ENDOTHELIUM CELL; GENE EXPRESSION; GENETIC TRANSFECTION; HEART DILATATION; HEART FAILURE; HEART FUNCTION; HEART INFARCTION; HEART INFARCTION SIZE; HEART LEFT VENTRICLE VOLUME; HEART MUSCLE FIBROSIS; HEART VENTRICLE FUNCTION; HISTOLOGY; ISOLATED HEART; LEFT ANTERIOR DESCENDING CORONARY ARTERY; MALE; MEASUREMENT; NONHUMAN; PLANIMETRY; PRIORITY JOURNAL; RAT; SCAR FORMATION; WESTERN BLOTTING;

ANIMALS; CELLS, CULTURED; CICATRIX; DRUG EVALUATION, PRECLINICAL; ELASTIN; ENDOTHELIAL CELLS; EXTRACELLULAR MATRIX; GENE THERAPY; HEART FAILURE, CONGESTIVE; HYPERTROPHY, LEFT VENTRICULAR; MALE; MYOCARDIAL INFARCTION; MYOCARDIUM; RANDOM ALLOCATION; RATS; RATS, INBRED LEW; RECOMBINANT FUSION PROTEINS; SINGLE-BLIND METHOD; TRANSFECTION; VENTRICULAR FUNCTION, LEFT; VENTRICULAR REMODELING;

EID: 24644490545     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.CIRCULATIONAHA.105.523795     Document Type: Article

References (24)

1. Raya TE, Gay RG, Lancaster L, Aguirre M, Moffett C, Goldman S. Serial changes in left ventricular relaxation and chamber stiffness after large myocardial infarction in rats. Circulation. 1988;77:1424-1431.
2. Pfeffer JM, Pfeffer MA, Fletcher PJ, Braunwald E. Progressive ventricular remodeling in rat with myocardial infarction. Am J Physiol. 1991;260:H1406-H1414.
3. Gupta KB, Ratcliffe MB, Fallert MA, Edmunds LH Jr, Bogen DK. Changes in passive mechanical stiffness of myocardial tissue with aneurysm formation. Circulation. 1994;89:2315-2326.
4. Li RK, Jia ZQ, Weisel RD, Mickle DA, Zhang J, Mohabeer MK, Rao V, Ivanov J. Cardiomyocyte transplantation improves heart function. Ann Thorac Surg. 1996;62:654-661.
5. Ghostine S, Carrion C, Souza LCG, Richard P, Bruneval P, Vilquin JT, Pouzet B, Schwanz K, Menasche P, Hagege AA. Long-term efficacy of myoblast transplantation on regional structure and function after myocardial infarction. Circulation. 2002;106(suppl I):I-131-I-136.
6. Yoo KJ, Li RK, Weisel RD, Mickle DA, Li G. Yau TM. Autologous smooth muscle cell transplantation improved heart function in dilated cardiomyopathy. Ann Thorac Surg. 2000;70:859-865.
7. Kielty CM, Sherratt MJ, Shuttleworth CA. Elastic fibres. J Cell Sci. 2002;115:2817-2828.
8. Yanagisawa H, Davis EC, Starcher BC, Ouchi T, Yanagisawa M, Richardson JA, Olson EN. Fibulin-5 is an elastin-binding protein essential for elastic fibre development in vivo. Nature. 2002;415:168-171.
9. Nakamura T, Lozano PR, Ikeda Y, Iwanaga Y, Hinek A, Minamisawa S, Cheng CF, Kobuke K, Dalton N, Takada Y, Tashiro K, Ross J Jr, Honjo T, Chien KR. Kbulin-5/DANCE is essential for elastogenesis in vivo. Nature. 2002;415:171-175.
10. Pereira L, Lee SY, Gayraud B, Andrikopoulos K, Shapiro SD, Bunton T, Biery NJ, Dietz HC, Sakai LY, Ramirez F. Pathogenetic sequence for aneurysm revealed in mice underexpressing fibrillin-1. Proc Natl Acad Sci U S A. 1999;96:3819-3823.
11. Li DY, Brooke B, Davis EC, Mecham RP, Sorensen LK, Boak BB, Eichwald E, Keating MT. Elastin is an essential determinant of arterial morphogenesis. Nature. 1998;393:276-280.
12. Parmley WW, Chuck L, Kivowitz C, Matloff JM, Swan HJ. In vitro length-tension relations of human ventricular aneurysms: relation of stiffness to mechanical disadvantage. Am J Cardiol. 1973;32:889-894.
13. Forrest L, Jackson DS. Intermolecular crosslinking of collagen in human and guinea pig scar tissue. Biochem Biophys Acta. 1971;229:681-689.
14. Kim EJ, Li RK, Weisel RD, Mickle DA, Jia ZQ, Tomita S, Sakai T, Yau TM. Angiogenesis by endothelial cell transplantation. J Thorac Cardiovasc Surg. 2001;122:963-971.
15. Li R-K, Mickle DAG, Weisel RD, Rao V, Jia Z-Q. Optimal time for cardiomyocyte transplantation to maximize myocardial function after left ventricular injury. Ann Thorac Surg. 2001;72:1957-1963.
16. Leobon B, Garcin I, Menasche P, Vilquin J-T, Audinat E, Charpak S. Myoblasts transplanted into rat infarcted myocardium are functionally isolated from their host. Proc Natl Acad Sci U S A. 2003;100:7808-7811.
17. Fedak PW, Smookler DS, Kassiri Z, Ohno N, Leco KJ, Verma S, Mickle DA, Watson KL, Hojilla CV, Cruz W, Weisel RD, Li RK, Khokha R. TIMP-3 deficiency leads to dilated cardiomyopathy. Circulation. 2004;110:2401-2409.
18. Fedak PWM, Altamentova SM, Weisel RD, Nili N, Ohno N, Verma S, Lee T-YJ, Kiani C, Mickle DAG, Strauss BH, Li R-K. Matrix remodeling in experimental and human heart failure: a possible regulatory role for TIMP-3. Am J Physiol. 2003;284:H626-H634.
19. Keeley FW, Bellingham CM, Woodhouse KA. Elastin as a self-organizing biomaterial: use of recombinantly expressed human elastin polypepeptides as a model for investigations of structure and self-assembly of elastin. Philos Trans R Soc Lond B Biol Sci. 2002;357:185-189.
20. Yau TM, Fung K, Weisel RD, Fujii T, Mickle DA, Li RK. Enhanced myocardial angiogenesis by gene transfer with transplanted cells. Circulation. 2001;104(suppl I):I-218-I-222.
21. Yau TM, Li G-M, Weisel RD, Reheman A, Jia Z-Q, Mickle DAG, Li R-K. Vascular endothelial growth factor transgene expression in cell-transplanted hearts. J Thorac Cardiovasc Surg. 2004;127:1180-1187.
22. Yau TM, Tomita S, Weisel RD, Jia Z-Q, Tumiati LC, Mickle DAG, Li R-K. Beneficial effect of autologous cell transplantation on infarcted heart function: comparison between bone marrow stromal cells and heart cells. Ann Thorac Surg. 2003;75:169-177.
23. Yasuda T, Weisel RD, Kiani C, Mickle DAG, Maganti M, Li R-K. Quantitative analysis of survival of transplanted smooth muscle cells with real-time polymerase chain reaction. J Thorac Cardiovasc Surg. 2005;129:904-911.
24. Liu T-B, Fedak PWM, Weisel RD, Yasuda T, Kiani G, Mickle DAG, Jia Z-Q, Li R-K. Enhanced IGF-1 expression improves smooth muscle cell engraftment after cell transplantation. Am J Physiol Heart Circ Physiol. 2004;287:H2840-H2849.