메뉴 건너뛰기




Volumn 123, Issue 8, 2013, Pages 3539-3551

A link between FTO, ghrelin, and impaired brain food-cue responsivity

(23)  Karra, Efthimia a   O'Daly, Owen G b   Choudhury, Agharul I c   Yousseif, Ahmed a   Millership, Steven c   Neary, Marianne T a   Scott, William R a   Chandarana, Keval a   Manning, Sean a   Hess, Martin E d,e,f   Iwakura, Hiroshi g   Akamizu, Takashi g   Millet, Queensta a   Gelegen, Cigdem a   Drew, Megan E a   Rahman, Sofia a   Emmanuel, Julian J a   Williams, Steven C R b   Rüther, Ulrich U h   Brüning, Jens C d,e,f   more..


Author keywords

[No Author keywords available]

Indexed keywords

6 N METHYLADENOSINE; ACYL GHRELIN; FAT MASS AND OBESITY ASSOCIATED PROTEIN; GHRELIN; MESSENGER RNA; PEPTIDE; PROTEIN; UNCLASSIFIED DRUG;

EID: 84881257670     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI44403     Document Type: Article
Times cited : (298)

References (74)
  • 1
    • 36749041363 scopus 로고    scopus 로고
    • The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase
    • Gerken T, et al. The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase. Science. 2007;318(5855):1469- 1472.
    • (2007) Science , vol.318 , Issue.5855 , pp. 1469-1472
    • Gerken, T.1
  • 2
    • 34248594090 scopus 로고    scopus 로고
    • A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity
    • Frayling TM, et al. A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science. 2007;316(5826):889-894.
    • (2007) Science , vol.316 , Issue.5826 , pp. 889-894
    • Frayling, T.M.1
  • 3
    • 34249777814 scopus 로고    scopus 로고
    • Variation in FTO contributes to childhood obesity and severe adult obesity
    • Dina C, et al. Variation in FTO contributes to childhood obesity and severe adult obesity. Nat Genet. 2007;39(6):724-726.
    • (2007) Nat Genet , vol.39 , Issue.6 , pp. 724-726
    • Dina, C.1
  • 4
    • 77949894041 scopus 로고    scopus 로고
    • Life course variations in the associations between FTO and MC4R gene variants and body size
    • Hardy R, et al. Life course variations in the associations between FTO and MC4R gene variants and body size. Hum Mol Genet. 2010;19(3):545-552.
    • (2010) Hum Mol Genet , vol.19 , Issue.3 , pp. 545-552
    • Hardy, R.1
  • 5
    • 84862564504 scopus 로고    scopus 로고
    • Association of genetic variation in FTO with risk of obesity and type 2 diabetes with data from 96,551 East and South Asians
    • Li H, et al. Association of genetic variation in FTO with risk of obesity and type 2 diabetes with data from 96,551 East and South Asians. Diabetologia. 2012;55(4):981-995.
    • (2012) Diabetologia , vol.55 , Issue.4 , pp. 981-995
    • Li, H.1
  • 6
    • 84869137850 scopus 로고    scopus 로고
    • Prospective analysis of the association of a common variant of FTO (rs9939609) with adiposity in children: Results of the IDEFICS study
    • Lauria F, et al. Prospective analysis of the association of a common variant of FTO (rs9939609) with adiposity in children: results of the IDEFICS study. PLoS One. 2012;7(11):e48876.
    • (2012) PLoS One , vol.7 , Issue.11
    • Lauria, F.1
  • 7
    • 57749121512 scopus 로고    scopus 로고
    • An obesity-associated FTO gene variant and increased energy intake in children
    • Cecil JE, Tavendale R, Watt P, Hetherington MM, Palmer CN. An obesity-associated FTO gene variant and increased energy intake in children. N Engl J Med. 2008;359(24):2558-2566.
    • (2008) N Engl J Med , vol.359 , Issue.24 , pp. 2558-2566
    • Cecil, J.E.1    Tavendale, R.2    Watt, P.3    Hetherington, M.M.4    Palmer, C.N.5
  • 8
    • 48749132799 scopus 로고    scopus 로고
    • Polymorphisms of the FTO gene are associated with variation in energy intake, but not energy expenditure
    • Speakman JR, Rance KA, Johnstone AM. Polymorphisms of the FTO gene are associated with variation in energy intake, but not energy expenditure. Obesity (Silver Spring). 2008;16(8):1961-1965.
    • (2008) Obesity (Silver Spring) , vol.16 , Issue.8 , pp. 1961-1965
    • Speakman, J.R.1    Rance, K.A.2    Johnstone, A.M.3
  • 10
    • 53849088890 scopus 로고    scopus 로고
    • The fat mass- and obesity-associated locus and dietary intake in children
    • Timpson NJ, et al. The fat mass- and obesity-associated locus and dietary intake in children. Am J Clin Nutr. 2008;88(4):971-978.
    • (2008) Am J Clin Nutr , vol.88 , Issue.4 , pp. 971-978
    • Timpson, N.J.1
  • 11
    • 72749115949 scopus 로고    scopus 로고
    • The FTO gene rs9939609 obesity-risk allele and loss of control over eating
    • Tanofsky-Kraff M, et al. The FTO gene rs9939609 obesity-risk allele and loss of control over eating. Am J Clin Nutr. 2009;90(6):1483-1488.
    • (2009) Am J Clin Nutr , vol.90 , Issue.6 , pp. 1483-1488
    • Tanofsky-Kraff, M.1
  • 13
    • 70350647201 scopus 로고    scopus 로고
    • Postprandial responses in hunger and satiety are associated with the rs9939609 single nucleotide polymorphism in FTO
    • den Hoed M, Westerterp-Plantenga MS, Bouwman FG, Mariman EC, Westerterp KR. Postprandial responses in hunger and satiety are associated with the rs9939609 single nucleotide polymorphism in FTO. Am J Clin Nutr. 2009;90(5):1426-1432.
    • (2009) Am J Clin Nutr , vol.90 , Issue.5 , pp. 1426-1432
    • Den Hoed, M.1    Westerterp-Plantenga, M.S.2    Bouwman, F.G.3    Mariman, E.C.4    Westerterp, K.R.5
  • 14
    • 84869102944 scopus 로고    scopus 로고
    • FTO at rs9939609, food responsiveness, emotional control and symptoms of ADHD in preschool children
    • Velders FP, et al. FTO at rs9939609, food responsiveness, emotional control and symptoms of ADHD in preschool children. PLoS One. 2012;7(11):e49131.
    • (2012) PLoS One , vol.7 , Issue.11
    • Velders, F.P.1
  • 15
    • 82355194591 scopus 로고    scopus 로고
    • FTO is expressed in neurones throughout the brain and its expression is unaltered by fasting
    • McTaggart JS, Lee S, Iberl M, Church C, Cox RD, Ashcroft FM. FTO is expressed in neurones throughout the brain and its expression is unaltered by fasting. PLoS One. 2011;6(11):e27968.
    • (2011) PLoS One , vol.6 , Issue.11
    • McTaggart, J.S.1    Lee, S.2    Iberl, M.3    Church, C.4    Cox, R.D.5    Ashcroft, F.M.6
  • 16
    • 41749092048 scopus 로고    scopus 로고
    • Regulation of Fto/Ftm gene expression in mice and humans
    • Stratigopoulos G, et al. Regulation of Fto/Ftm gene expression in mice and humans. Am J Physiol Regul Integr Comp Physiol. 2008;294(4):R1185-R1196.
    • (2008) Am J Physiol Regul Integr Comp Physiol , vol.294 , Issue.4
    • Stratigopoulos, G.1
  • 17
    • 42249083837 scopus 로고    scopus 로고
    • The obesity gene, FTO, is of ancient origin, up-regulated during food deprivation and expressed in neurons of feeding-related nuclei of the brain
    • Fredriksson R, et al. The obesity gene, FTO, is of ancient origin, up-regulated during food deprivation and expressed in neurons of feeding-related nuclei of the brain. Endocrinology. 2008;149(5):2062-2071.
    • (2008) Endocrinology , vol.149 , Issue.5 , pp. 2062-2071
    • Fredriksson, R.1
  • 18
    • 70549105941 scopus 로고    scopus 로고
    • Hypothalamic FTO is associated with the regulation of energy intake not feeding reward
    • Olszewski PK, et al. Hypothalamic FTO is associated with the regulation of energy intake not feeding reward. BMC Neurosci. 2009;10:129.
    • (2009) BMC Neurosci , vol.10 , pp. 129
    • Olszewski, P.K.1
  • 19
    • 79957945033 scopus 로고    scopus 로고
    • Involvement of leptin receptor long isoform (LepRb)-STAT3 signaling pathway in brain fat mass- and obesity-associated (FTO) downregulation during energy restriction
    • Wang P, et al. Involvement of leptin receptor long isoform (LepRb)-STAT3 signaling pathway in brain fat mass- and obesity-associated (FTO) downregulation during energy restriction. Mol Med. 2011;17(5-6):523-532.
    • (2011) Mol Med , vol.17 , Issue.5-6 , pp. 523-532
    • Wang, P.1
  • 20
    • 84856246018 scopus 로고    scopus 로고
    • Expression of new loci associated with obesity in diet-induced obese rats: From genetics to physiology
    • Gutierrez-Aguilar R, Kim DH, Woods SC, Seeley RJ. Expression of new loci associated with obesity in diet-induced obese rats: from genetics to physiology. Obesity (Silver Spring). 2012;20(2):306-312.
    • (2012) Obesity (Silver Spring) , vol.20 , Issue.2 , pp. 306-312
    • Gutierrez-Aguilar, R.1    Kim, D.H.2    Woods, S.C.3    Seeley, R.J.4
  • 21
    • 84870301814 scopus 로고    scopus 로고
    • Nutritional state affects the expression of the obesity-associated genes Etv5, Faim2, Fto, and Negr1
    • Boender AJ, van Rozen AJ, Adan RA. Nutritional state affects the expression of the obesity-associated genes Etv5, Faim2, Fto, and Negr1. Obesity (Silver Spring). 2012;20(12):2420-2425.
    • (2012) Obesity (Silver Spring) , vol.20 , Issue.12 , pp. 2420-2425
    • Boender, A.J.1    Van Rozen, A.J.2    Adan, R.A.3
  • 22
    • 77649303960 scopus 로고    scopus 로고
    • Hypothalamic-specific manipulation of Fto, the ortholog of the human obesity gene FTO, affects food intake in rats
    • Tung YC, et al. Hypothalamic-specific manipulation of Fto, the ortholog of the human obesity gene FTO, affects food intake in rats. PLoS One. 2010;5(1):e8771.
    • (2010) PLoS One , vol.5 , Issue.1
    • Tung, Y.C.1
  • 23
    • 84877577199 scopus 로고    scopus 로고
    • FTO expression is regulated by availability of essential amino acids
    • Cheung MK, Gulati P, O'Rahilly S, Yeo GS. FTO expression is regulated by availability of essential amino acids. Int J Obes (Lond). 2013;37(5):744-747.
    • (2013) Int J Obes (Lond) , vol.37 , Issue.5 , pp. 744-747
    • Cheung, M.K.1    Gulati, P.2    O'Rahilly, S.3    Yeo, G.S.4
  • 24
    • 84873735640 scopus 로고    scopus 로고
    • Role for the obesity-related FTO gene in the cellular sensing of amino acids
    • Gulati P, et al. Role for the obesity-related FTO gene in the cellular sensing of amino acids. Proc Natl Acad Sci U S A. 2013;110(7):2557-2562.
    • (2013) Proc Natl Acad Sci U S A , vol.110 , Issue.7 , pp. 2557-2562
    • Gulati, P.1
  • 25
    • 67349211789 scopus 로고    scopus 로고
    • Inactivation of the Fto gene protects from obesity
    • Fischer J, et al. Inactivation of the Fto gene protects from obesity. Nature. 2009;458(7240):894-898.
    • (2009) Nature , vol.458 , Issue.7240 , pp. 894-898
    • Fischer, J.1
  • 26
    • 78649512744 scopus 로고    scopus 로고
    • The fat mass and obesity associated gene FTO functions in the brain to regulate postnatal growth in mice
    • Gao X, Shin YH, Li M, Wang F, Tong Q, Zhang P. The fat mass and obesity associated gene FTO functions in the brain to regulate postnatal growth in mice. PLoS One. 2010;5(11):e14005.
    • (2010) PLoS One , vol.5 , Issue.11
    • Gao, X.1    Shin, Y.H.2    Li, M.3    Wang, F.4    Tong, Q.5    Zhang, P.6
  • 27
    • 84873520661 scopus 로고    scopus 로고
    • Adult onset global loss of the fto gene alters body composition and metabolism in the mouse
    • McMurray F, et al. Adult onset global loss of the fto gene alters body composition and metabolism in the mouse. PLoS Genet. 2013;9(1):e1003166.
    • (2013) PLoS Genet , vol.9 , Issue.1
    • McMurray, F.1
  • 28
    • 70149100469 scopus 로고    scopus 로고
    • A mouse model for the metabolic effects of the human fat mass and obesity associated FTO gene
    • Church C, et al. A mouse model for the metabolic effects of the human fat mass and obesity associated FTO gene. PLoS Genet. 2009;5(8):e1000599.
    • (2009) PLoS Genet , vol.5 , Issue.8
    • Church, C.1
  • 29
    • 78649459183 scopus 로고    scopus 로고
    • Overexpression of Fto leads to increased food intake and results in obesity
    • Church C, et al. Overexpression of Fto leads to increased food intake and results in obesity. Nat Genet. 2010;42(12):1086-1092.
    • (2010) Nat Genet , vol.42 , Issue.12 , pp. 1086-1092
    • Church, C.1
  • 30
    • 81355146483 scopus 로고    scopus 로고
    • N6-methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO
    • Jia G, et al. N6-methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO. Nat Chem Biol. 2011;7(12):885-887.
    • (2011) Nat Chem Biol , vol.7 , Issue.12 , pp. 885-887
    • Jia, G.1
  • 31
    • 84860779086 scopus 로고    scopus 로고
    • Topology of the human and mouse m6A RNA methylomes revealed by m6Aseq
    • Dominissini D, et al. Topology of the human and mouse m6A RNA methylomes revealed by m6Aseq. Nature. 2012;485(7397):201-206.
    • (2012) Nature , vol.485 , Issue.7397 , pp. 201-206
    • Dominissini, D.1
  • 32
    • 84862649489 scopus 로고    scopus 로고
    • Comprehensive analysis of mRNA methylation reveals enrichment in 3' UTRs and near stop codons
    • Meyer KD, Saletore Y, Zumbo P, Elemento O, Mason CE, Jaffrey SR. Comprehensive analysis of mRNA methylation reveals enrichment in 3' UTRs and near stop codons. Cell. 2012;149(7):1635-1646.
    • (2012) Cell , vol.149 , Issue.7 , pp. 1635-1646
    • Meyer, K.D.1    Saletore, Y.2    Zumbo, P.3    Elemento, O.4    Mason, C.E.5    Jaffrey, S.R.6
  • 33
    • 33846032275 scopus 로고    scopus 로고
    • Gastrointestinal regulation of food intake
    • Cummings DE, Overduin J. Gastrointestinal regulation of food intake. J Clin Invest. 2007;117(1):13-23.
    • (2007) J Clin Invest , vol.117 , Issue.1 , pp. 13-23
    • Cummings, D.E.1    Overduin, J.2
  • 34
    • 0035216623 scopus 로고    scopus 로고
    • Ghrelin enhances appetite and increases food intake in humans
    • Wren AM, et al. Ghrelin enhances appetite and increases food intake in humans. J Clin Endocrinol Metab. 2001;86(12):5992.
    • (2001) J Clin Endocrinol Metab , vol.86 , Issue.12 , pp. 5992
    • Wren, A.M.1
  • 35
    • 0037043704 scopus 로고    scopus 로고
    • Gut hormone PYY(3-36) physiologically inhibits food intake
    • Batterham RL, et al. Gut hormone PYY(3-36) physiologically inhibits food intake. Nature. 2002; 418(6898):650-654.
    • (2002) Nature , vol.418 , Issue.6898 , pp. 650-654
    • Batterham, R.L.1
  • 36
    • 0041859261 scopus 로고    scopus 로고
    • Inhibition of food intake in obese subjects by peptide YY3-36
    • Batterham RL, et al. Inhibition of food intake in obese subjects by peptide YY3-36. N Engl J Med. 2003; 349(10):941-948.
    • (2003) N Engl J Med , vol.349 , Issue.10 , pp. 941-948
    • Batterham, R.L.1
  • 37
    • 42649116436 scopus 로고    scopus 로고
    • Ghrelin modulates brain activity in areas that control appetitive behavior
    • Malik S, McGlone F, Bedrossian D, Dagher A. Ghrelin modulates brain activity in areas that control appetitive behavior. Cell Metab. 2008;7(5):400-409.
    • (2008) Cell Metab , vol.7 , Issue.5 , pp. 400-409
    • Malik, S.1    McGlone, F.2    Bedrossian, D.3    Dagher, A.4
  • 38
    • 77950371376 scopus 로고    scopus 로고
    • Ghrelin increases the rewarding value of high-fat diet in an orexin-dependent manner
    • Perello M, et al. Ghrelin increases the rewarding value of high-fat diet in an orexin-dependent manner. Biol Psychiatry. 2010;67(9):880-886.
    • (2010) Biol Psychiatry , vol.67 , Issue.9 , pp. 880-886
    • Perello, M.1
  • 39
    • 35948998870 scopus 로고    scopus 로고
    • PYY modulation of cortical and hypothalamic brain areas predicts feeding behaviour in humans
    • Batterham RL, et al. PYY modulation of cortical and hypothalamic brain areas predicts feeding behaviour in humans. Nature. 2007;450(7166):106-109.
    • (2007) Nature , vol.450 , Issue.7166 , pp. 106-109
    • Batterham, R.L.1
  • 40
    • 77954501905 scopus 로고    scopus 로고
    • Establishment of a novel ghrelin-producing cell line
    • Iwakura H, et al. Establishment of a novel ghrelin-producing cell line. Endocrinology. 2010;151(6):2940-2945.
    • (2010) Endocrinology , vol.151 , Issue.6 , pp. 2940-2945
    • Iwakura, H.1
  • 41
    • 66149150954 scopus 로고    scopus 로고
    • Subject standardization, acclimatization, and sample processing affect gut hormone levels and appetite in humans
    • Chandarana K, et al. Subject standardization, acclimatization, and sample processing affect gut hormone levels and appetite in humans. Gastroenterology. 2009;136(7):2115-2126.
    • (2009) Gastroenterology , vol.136 , Issue.7 , pp. 2115-2126
    • Chandarana, K.1
  • 42
    • 72049125602 scopus 로고    scopus 로고
    • Human and rodent homologies in action control: Corticostriatal determinants of goal-directed and habitual action
    • Balleine BW, O'Doherty JP. Human and rodent homologies in action control: corticostriatal determinants of goal-directed and habitual action. Neuropsychopharmacology. 2010;35(1):48-69.
    • (2010) Neuropsychopharmacology , vol.35 , Issue.1 , pp. 48-69
    • Balleine, B.W.1    O'Doherty, J.P.2
  • 43
    • 84883797806 scopus 로고    scopus 로고
    • (Still) longing for food: Insulin reactivity modulates response to food pictures [published online ahead of print March 28, 2012]
    • doi:10.1002/hbm.22071
    • Kroemer NB, et al. (Still) longing for food: Insulin reactivity modulates response to food pictures [published online ahead of print March 28, 2012]. Hum Brain Mapp. doi:10.1002/hbm.22071.
    • Hum Brain Mapp
    • Kroemer, N.B.1
  • 44
    • 78651293496 scopus 로고    scopus 로고
    • Dissociating valuation and saliency signals during decisionmaking
    • Litt A, Plassmann H, Shiv B, Rangel A. Dissociating valuation and saliency signals during decisionmaking. Cereb Cortex. 2011;21(1):95-102.
    • (2011) Cereb Cortex , vol.21 , Issue.1 , pp. 95-102
    • Litt, A.1    Plassmann, H.2    Shiv, B.3    Rangel, A.4
  • 45
    • 84856514258 scopus 로고    scopus 로고
    • Dorsal striatum and its limbic connectivity mediate abnormal anticipatory reward processing in obesity
    • Nummenmaa L, et al. Dorsal striatum and its limbic connectivity mediate abnormal anticipatory reward processing in obesity. PLoS One. 2012;7(2):e31089.
    • (2012) PLoS One , vol.7 , Issue.2
    • Nummenmaa, L.1
  • 46
    • 38849090670 scopus 로고    scopus 로고
    • Identification of the acyltransferase that octanoylates ghrelin, an appetite-stimulating peptide hormone
    • Yang J, Brown MS, Liang G, Grishin NV, Goldstein JL. Identification of the acyltransferase that octanoylates ghrelin, an appetite-stimulating peptide hormone. Cell. 2008;132(3):387-396.
    • (2008) Cell , vol.132 , Issue.3 , pp. 387-396
    • Yang, J.1    Brown, M.S.2    Liang, G.3    Grishin, N.V.4    Goldstein, J.L.5
  • 47
    • 77958485625 scopus 로고    scopus 로고
    • Gene expression of FTO in human subcutaneous adipose tissue, peripheral blood mononuclear cells and adipocyte cell line
    • Lappalainen T, et al. Gene expression of FTO in human subcutaneous adipose tissue, peripheral blood mononuclear cells and adipocyte cell line. J Nutrigenet Nutrigenomics. 2010;3(1):37-45.
    • (2010) J Nutrigenet Nutrigenomics , vol.3 , Issue.1 , pp. 37-45
    • Lappalainen, T.1
  • 48
    • 41749125483 scopus 로고    scopus 로고
    • Expression of ghrelin gene in peripheral blood mononuclear cells and plasma ghrelin concentrations in patients with metabolic syndrome
    • Mager U, et al. Expression of ghrelin gene in peripheral blood mononuclear cells and plasma ghrelin concentrations in patients with metabolic syndrome. Eur J Endocrinol. 2008;158(4):499-510.
    • (2008) Eur J Endocrinol , vol.158 , Issue.4 , pp. 499-510
    • Mager, U.1
  • 49
    • 0034687376 scopus 로고    scopus 로고
    • Ghrelin induces adiposity in rodents
    • Tschop M, Smiley DL, Heiman ML. Ghrelin induces adiposity in rodents. Nature. 2000;407(6806):908-913.
    • (2000) Nature , vol.407 , Issue.6806 , pp. 908-913
    • Tschop, M.1    Smiley, D.L.2    Heiman, M.L.3
  • 50
    • 33748560432 scopus 로고    scopus 로고
    • Ghrelin modulates the activity and synaptic input organization of midbrain dopamine neurons while promoting appetite
    • Abizaid A, et al. Ghrelin modulates the activity and synaptic input organization of midbrain dopamine neurons while promoting appetite. J Clin Invest. 2006;116(12):3229-3239.
    • (2006) J Clin Invest , vol.116 , Issue.12 , pp. 3229-3239
    • Abizaid, A.1
  • 51
    • 84864589380 scopus 로고    scopus 로고
    • The role of ghrelin in rewardbased eating
    • Perello M, Zigman JM. The role of ghrelin in rewardbased eating. Biol Psychiatry. 2012;72(5):347-353.
    • (2012) Biol Psychiatry , vol.72 , Issue.5 , pp. 347-353
    • Perello, M.1    Zigman, J.M.2
  • 52
    • 0033540056 scopus 로고    scopus 로고
    • Ghrelin is a growth-hormone-releasing acylated peptide from stomach
    • Kojima M, Hosoda H, Date Y, Nakazato M, Matsuo H, Kangawa K. Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature. 1999;402(6762):656-660.
    • (1999) Nature , vol.402 , Issue.6762 , pp. 656-660
    • Kojima, M.1    Hosoda, H.2    Date, Y.3    Nakazato, M.4    Matsuo, H.5    Kangawa, K.6
  • 53
    • 84868210192 scopus 로고    scopus 로고
    • GOAT induced ghrelin acylation regulates hedonic feeding
    • Davis JF, et al. GOAT induced ghrelin acylation regulates hedonic feeding. Horm Behav. 2012; 62(5):598-604.
    • (2012) Horm Behav , vol.62 , Issue.5 , pp. 598-604
    • Davis, J.F.1
  • 54
    • 0035514596 scopus 로고    scopus 로고
    • Ghrelin causes hyperphagia and obesity in rats
    • Wren AM, et al. Ghrelin causes hyperphagia and obesity in rats. Diabetes. 2001;50(11):2540-2547.
    • (2001) Diabetes , vol.50 , Issue.11 , pp. 2540-2547
    • Wren, A.M.1
  • 55
    • 38549133092 scopus 로고    scopus 로고
    • Characterization of adult ghrelin and ghrelin receptor knockout mice under positive and negative energy balance
    • Sun Y, Butte NF, Garcia JM, Smith RG. Characterization of adult ghrelin and ghrelin receptor knockout mice under positive and negative energy balance. Endocrinology. 2008;149(2):843-850.
    • (2008) Endocrinology , vol.149 , Issue.2 , pp. 843-850
    • Sun, Y.1    Butte, N.F.2    Garcia, J.M.3    Smith, R.G.4
  • 56
    • 81755173582 scopus 로고    scopus 로고
    • Physiological roles revealed by ghrelin and ghrelin receptor deficient mice
    • Albarran-Zeckler RG, Sun Y, Smith RG. Physiological roles revealed by ghrelin and ghrelin receptor deficient mice. Peptides. 2011;32(11):2229-2235.
    • (2011) Peptides , vol.32 , Issue.11 , pp. 2229-2235
    • Albarran-Zeckler, R.G.1    Sun, Y.2    Smith, R.G.3
  • 57
    • 31044451759 scopus 로고    scopus 로고
    • Mice lacking ghrelin receptors resist the development of diet-induced obesity
    • Zigman JM, et al. Mice lacking ghrelin receptors resist the development of diet-induced obesity. J Clin Invest. 2005;115(12):3564-3572.
    • (2005) J Clin Invest , vol.115 , Issue.12 , pp. 3564-3572
    • Zigman, J.M.1
  • 58
    • 31044452189 scopus 로고    scopus 로고
    • Absence of ghrelin protects against early-onset obesity
    • Wortley KE, et al. Absence of ghrelin protects against early-onset obesity. J Clin Invest. 2005; 115(12):3573-3578.
    • (2005) J Clin Invest , vol.115 , Issue.12 , pp. 3573-3578
    • Wortley, K.E.1
  • 59
    • 85027956104 scopus 로고    scopus 로고
    • Disruption of cue-potentiated feeding in mice with blocked ghrelin signaling
    • Walker AK, Ibia IE, Zigman JM. Disruption of cue-potentiated feeding in mice with blocked ghrelin signaling. Physiol Behav. 2012;108:34-43.
    • (2012) Physiol Behav , vol.108 , pp. 34-43
    • Walker, A.K.1    Ibia, I.E.2    Zigman, J.M.3
  • 60
    • 33646582664 scopus 로고    scopus 로고
    • Hypothalamic mTOR signaling regulates food intake
    • Cota D, et al. Hypothalamic mTOR signaling regulates food intake. Science. 2006;312(5775):927-930.
    • (2006) Science , vol.312 , Issue.5775 , pp. 927-930
    • Cota, D.1
  • 61
    • 49049114337 scopus 로고    scopus 로고
    • The role of hypothalamic mammalian target of rapamycin complex 1 signaling in diet-induced obesity
    • Cota D, Matter EK, Woods SC, Seeley RJ. The role of hypothalamic mammalian target of rapamycin complex 1 signaling in diet-induced obesity. J Neurosci. 2008;28(28):7202-7208.
    • (2008) J Neurosci , vol.28 , Issue.28 , pp. 7202-7208
    • Cota, D.1    Matter, E.K.2    Woods, S.C.3    Seeley, R.J.4
  • 62
    • 84875530060 scopus 로고    scopus 로고
    • N6-methyl-adenosine modification in messenger and long non-coding RNA
    • Pan T. N6-methyl-adenosine modification in messenger and long non-coding RNA. Trends Biochem Sci. 2013;38(4):204-209.
    • (2013) Trends Biochem Sci , vol.38 , Issue.4 , pp. 204-209
    • Pan, T.1
  • 64
    • 84867070330 scopus 로고    scopus 로고
    • Human beta cell transcriptome analysis uncovers lncRNAs that are tissue-specific, dynamically regulated, and abnormally expressed in type 2 diabetes
    • Moran I, et al. Human beta cell transcriptome analysis uncovers lncRNAs that are tissue-specific, dynamically regulated, and abnormally expressed in type 2 diabetes. Cell Metab. 2012;16(4):435-448.
    • (2012) Cell Metab , vol.16 , Issue.4 , pp. 435-448
    • Moran, I.1
  • 65
    • 68649091204 scopus 로고    scopus 로고
    • An expanded view of energy homeostasis: Neural integration of metabolic, cognitive, and emotional drives to eat
    • Shin AC, Zheng H, Berthoud HR. An expanded view of energy homeostasis: neural integration of metabolic, cognitive, and emotional drives to eat. Physiol Behav. 2009;97(5):572-580.
    • (2009) Physiol Behav , vol.97 , Issue.5 , pp. 572-580
    • Shin, A.C.1    Zheng, H.2    Berthoud, H.R.3
  • 66
    • 84882732955 scopus 로고    scopus 로고
    • Fasting levels of ghrelin covary with the brain response to food pictures [published online ahead of print September 13, 2012]
    • doi:10.1111/j.1369-1600.2012.00489.x
    • Kroemer NB, et al. Fasting levels of ghrelin covary with the brain response to food pictures [published online ahead of print September 13, 2012]. Addict Biol. doi:10.1111/j.1369-1600.2012.00489.x.
    • Addict Biol
    • Kroemer, N.B.1
  • 67
    • 0345375270 scopus 로고    scopus 로고
    • Plasma ghrelin, body fat, insulin resistance, and smoking in clinically healthy men: The atherosclerosis and insulin resistance study
    • Fagerberg B, Hulten LM, Hulthe J. Plasma ghrelin, body fat, insulin resistance, and smoking in clinically healthy men: the atherosclerosis and insulin resistance study. Metabolism. 2003;52(11):1460-1463.
    • (2003) Metabolism , vol.52 , Issue.11 , pp. 1460-1463
    • Fagerberg, B.1    Hulten, L.M.2    Hulthe, J.3
  • 68
    • 77954959140 scopus 로고    scopus 로고
    • Body mass correlates inversely with inhibitory control in response to food among adolescent girls: An fMRI study
    • Batterink L, Yokum S, Stice E. Body mass correlates inversely with inhibitory control in response to food among adolescent girls: an fMRI study. NeuroImage. 2010;52(4):1696-1703.
    • (2010) NeuroImage , vol.52 , Issue.4 , pp. 1696-1703
    • Batterink, L.1    Yokum, S.2    Stice, E.3
  • 69
    • 0033839458 scopus 로고    scopus 로고
    • Healthy percentage body fat ranges: An approach for developing guidelines based on body mass index
    • Gallagher D, Heymsfield SB, Heo M, Jebb SA, Murgatroyd PR, Sakamoto Y. Healthy percentage body fat ranges: an approach for developing guidelines based on body mass index. Am J Clin Nutr. 2000; 72(3):694-701.
    • (2000) Am J Clin Nutr , vol.72 , Issue.3 , pp. 694-701
    • Gallagher, D.1    Heymsfield, S.B.2    Heo, M.3    Jebb, S.A.4    Murgatroyd, P.R.5    Sakamoto, Y.6
  • 70
    • 84875222390 scopus 로고    scopus 로고
    • Relationship between BMI and body fatness in three European countries
    • Ramel A, et al. Relationship between BMI and body fatness in three European countries. Eur J Clin Nutr. 2013;67(3):254-258.
    • (2013) Eur J Clin Nutr , vol.67 , Issue.3 , pp. 254-258
    • Ramel, A.1
  • 71
    • 34247645945 scopus 로고    scopus 로고
    • Body mass index as a predictor of percent fat in college athletes and nonathletes
    • Ode JJ, Pivarnik JM, Reeves MJ, Knous JL. Body mass index as a predictor of percent fat in college athletes and nonathletes. Med Sci Sports Exerc. 2007; 39(3):403-409.
    • (2007) Med Sci Sports Exerc , vol.39 , Issue.3 , pp. 403-409
    • Ode, J.J.1    Pivarnik, J.M.2    Reeves, M.J.3    Knous, J.L.4
  • 73
    • 44149127949 scopus 로고    scopus 로고
    • Widespread reward-system activation in obese women in response to pictures of high-calorie foods
    • Stoeckel LE, Weller RE, Cook EW 3rd, Twieg DB, Knowlton RC, Cox JE. Widespread reward-system activation in obese women in response to pictures of high-calorie foods. NeuroImage. 2008;41(2):636-647.
    • (2008) NeuroImage , vol.41 , Issue.2 , pp. 636-647
    • Stoeckel, L.E.1    Weller, R.E.2    Cook III, E.W.3    Twieg, D.B.4    Knowlton, R.C.5    Cox, J.E.6
  • 74
    • 0029096148 scopus 로고
    • Analysis of fMRI time-series revisited-again
    • Worsley KJ, Friston KJ. Analysis of fMRI time-series revisited-again. NeuroImage. 1995;2(3):173-181.
    • (1995) NeuroImage , vol.2 , Issue.3 , pp. 173-181
    • Worsley, K.J.1    Friston, K.J.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.