Food restriction markedly increases dopamine D2 receptor (D2R) in a rat model of obesity as assessed with in-vivo μPET imaging ([11C] raclopride) and in-vitro ([3H] spiperone) autoradiography

Synapse

Volumn 62, Issue 1, 2008, Pages 50-61

  Thanos, Panayotis K ^a,b   Michaelides, Michael ^a   Piyis, Yiannis K ^a   Wang, Gene Jack ^a   Volkow, Nora D ^b  

^a BROOKHAVEN NATIONAL LABORATORY   (United States)

^b NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM   (United States)

Author keywords

imager; PET; Addiction; Drug abuse; Environment; Gene therapy; Reward

Indexed keywords

DOPAMINE 2 RECEPTOR; LEPTIN RECEPTOR; RACLOPRIDE C 11; SPIPERONE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTORADIOGRAPHY; BEHAVIOR; CONTROLLED STUDY; CORPUS STRIATUM; DIET RESTRICTION; DOPAMINE RELEASE; IMAGING; IN VITRO STUDY; IN VIVO STUDY; INTERMETHOD COMPARISON; LEAN BODY WEIGHT; MALE; NONHUMAN; OBESITY; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RECEPTOR BINDING; SENSITIVITY AND SPECIFICITY; ZUCKER RAT;

AGE FACTORS; ANIMALS; APOMORPHINE; APPETITE REGULATION; AUTORADIOGRAPHY; BRAIN; DISEASE MODELS, ANIMAL; DOPAMINE; DOPAMINE AGONISTS; EATING; FOOD DEPRIVATION; MALE; MOTOR ACTIVITY; OBESITY; POSITRON-EMISSION TOMOGRAPHY; RACLOPRIDE; RATS; RATS, ZUCKER; RECEPTORS, DOPAMINE D2; RECEPTORS, LEPTIN; SPIPERONE; TRITIUM;

EID: 36348992560     PISSN: 08874476     EISSN: 10982396     Source Type: Journal    
DOI: 10.1002/syn.20468     Document Type: Article

References (59)

1. Carr KD. 2006. Chronic food restriction: Enhancing effects on drug reward and striatal cell signaling. Physiol Behav 91:459-472.
2. Carr KD, Tsimberg Y, Berman Y, Yamamoto N. 2003. Evidence of increased dopamine receptor signaling in food-restricted rats. Neuroscience 119:1157-1167.
3. Chua SJ, Chung W, WU-Peng X. 1996. Phenotypes of mouse diabetes and rat fatty due to mutations in the OB (leptin) receptor. Science NY 271:994.
4. Dias FR, Carey RJ, Carrera MP. 2006. Conditioned locomotion induced by unilateral intrastriatal administration of apomorphine: D(2) receptor activation is critical but not the expression of the unconditioned response. Brain Res 1083:85-95.
5. Fenu S, Di Chiara G. 2003. Facilitation of conditioned taste aversion learning by systemic amphetamine: Role of nucleus accumbens shell dopamine D1 receptors. Eur J Neurosci 18:2025-2030.
6. Fetissov SO, Meguid MM, Shafiroff M, Miyata G, Torelli GF. 2000. Dopamine in the VMN of the hypothalamus is important for diurnal distribution of eating in obese male Zucker rats. Nutrition 16:65-66.
7. Figlewicz DP, Patterson TA, Johnson LB, Zavosh A, Israel PA, Szot P. 1998. Dopamine transporter mRNA is increased in the CNS of Zucker fatty (fa/fa) rats. Brain Res Bull 46:199-202.
8. Figlewicz DP, Evans SB, Murphy J, Hoen M, Baskin DG. 2003. Expression of receptors for insulin and leptin in the ventral tegmental area/substantia nigra (VTA/SN) of the rat. Brain Res 964:107-115.
9. Flegal C, Ogden J. 2002. Prevalence and trends in obesity among US adults, 1999-2000. J Am Med Assoc 288:1772-1773.
10. 11C]raclopride. Biol Psychiatry 58:908-912.
11. Friedman JM. 2004. Modern science versus the stigma of obesity. Nat Med 10:563-569.
12. Fukuyama H, Hayashi T, Katsumi Y, Tsukada H, Shibasaki H. 1998. Issues in measuring glucose metabolism of rat brain using PET: The effect of harderian glands on the frontal lobe. Neurosci Lett 255:99-102.
13. Fulton S, Pissios P, Manchon RP, Stiles L, Frank L, Pothos EN, Maratos-Flier E, Flier JS. 2006. Leptin regulation of the mesoaccumbens dopamine pathway. Neuron 51:811-822.
14. Gainetdinov RR, Jones SR, Caron MG. 1999. Functional hyperdopaminergia in dopamine transporter knock-out mice. Biol Psychiatry 46:303-311.
15. Hagan MM, Havel PJ, Seeley RJ, Woods SC, Ekhator NN, Baker DG, Hill KK, Wortman MD, Miller AH, Gingerich RL, Geracioti TD. 1999. Cerebrospinal fluid and plasma leptin measurements: Covariability with dopamine and cortisol in fasting humans. J Clin Endocrinol Metab 84:3579-3585.
16. Hamdi A, Porter J, Prasad C. 1992. Decreased striatal D2 dopamine receptors in obese Zucker rats: Changes during aging. Brain Res 589:338-340.
17. Hume SP, Lammertsma AA, Myers R, Rajeswaran S, Bloomfield PM, Ashworth S, Flicker RA, Torres EM, Watson C, Jones T. 1996. The potential of High-resolution Positron Emission Tomography to monitor striatal dopaminergic function in rat models of disease. J Neurosci Methods 67:103-112.
18. Ichise M, Liow JS, Lu JQ, Takano A, Model K, Toyama H, Suhara T, Suzuki K, Innis RB, Carson RE. 2003. Linearized reference tissue parametric imaging methods: Application to [11C]DASB positron emission tomography studies of the serotonin transporter in human brain. J Cereb Blood Flow Metab 23:1096-1112.
19. Ingram DK, Chefer S, Matochik J, Moscrip TD, Weed J, Roth GS, London ED, Lane MA. 2001. Aging and caloric restriction in nonhuman primates: Behavioral and in vivo brain imaging studies. Ann NY Acad Sci 928:316-326.
20. Jenner P. 2003. Dopamine agonists, receptor selectivity and dyskinesia induction in Parkinson's disease. Curr Opin Neurol 16 (Suppl 1):S3-S7.
21. Kapur S, Seeman P. 2002. NMDA receptor antagonists ketamine and PCP have direct effects on the dopamine D(2) and serotonin 5-HT(2)receptors-implications for models of schizophrenia. Mol Psychiatry 7:837-844.
22. Krugel U, Schraft T, Kittner H, Kiess W, Illes P. 2003. Basal and feeding-evoked dopamine release in the rat nucleus accumbens is depressed by leptin. Eur J Pharmacol 482(1-3):185-187.
23. Kuge Y, Minematsu K, Hasegawa Y, Yamaguchi T, Mori H, Matsuura H, Hashimoto N, Miyake Y. 1997. Positron emission tomography for quantitative determination of glucose metabolism in normal and ischemic brains in rats: An insoluble problem by the Harderian glands. J Cereb Blood Flow Metab 17:116-120.
24. Laforest R, Sharp TL, Engelbach JA, Fettig NM, Herrero P, Kim J, Lewis JS, Rowland DJ, Tai YC, Welch MJ. 2005. Measurement of input functions in rodents: Challenges and solutions. Nucl Med Biol 32:679-685.
25. Langlois X, te Riele P, Wintmolders C, Leysen JE, Jurzak M. 2001. Use of the beta-imager for rapid ex vivo autoradiography exemplified with central nervous system penetrating neurokinin 3 antagonists. J Pharmacol Exp Ther 299:712-717.
26. Laruelle M. 2000. Imaging synaptic neurotransmission with in vivo binding competition techniques: A critical review. J Cereb Blood Flow Metab 20:423-451.
27. Matej S, Karp JS, Lewitt RM, Becher AJ. 1998. Performance of the Fourier rebinning algorithm for PET with large acceptance angles. Phys Med Biol 43:787-795.
28. McClure SM, Daw ND, Montague PR. 2003. A computational substrate for incentive salience. Trends Neurosci 26:423-428.
29. McQuade JA, Benoit SC, Xu M, Woods SC, Seeley RJ. 2004. High-fat diet induced adiposity in mice with targeted disruption of the dopamine-3 receptor gene. Behav Brain Res 151(1-2):313-319.
30. Meguid MM, Fetissov SO, Blaha V, Yang ZJ. 2000. Dopamine and serotonin VMN release is related to feeding status in obese and lean Zucker rats. Neuroreport 11:2069-2072.
31. Miklya I, Knoll B, Knoll J. 2003. An HPLC tracing of the enhancer regulation in selected discrete brain areas of food-deprived rats. Life Sci 72:2923-2930.
32. Morris ED, Yoder KK. 2007. Positron emission tomography displacement sensitivity: Predicting binding potential change for positron emission tomography tracers based on their kinetic characteristics. J Cereb Blood Flow Metab 27:606-617.
33. NAS, NRC. 1996. Guide for the care and use of laboratory animals. Washington DC: National Academy Press.
34. Orosco M, Rouch C, Gripois D, Blouquit MF, Roffi J, Jacquot C, Cohen Y. 1992. Striatal dopamine metabolism is differentially affected by insulin according to the genotype in Zucker rats: A microdialysis study. Psychoneuroendocrinology 17:443-452.
35. Orosco M, Trouvin JH, Cohen Y, Jacquot C. 1986. Ontogeny of brain monoamines in lean and obese female Zucker rats. Physiol Behav 36:853-856.
36. Orosco M, Rouch C, Meile M, Nicolaidis S. 1995. Spontaneous feeding-related monoamine changes in rostromedial hypothalamus of the obese Zucker rat: A microdialysis study. Physiol Behav 57:1103-1106.
37. Owens WA, Sevak RJ, Galici R, Chang X, Javors MA, Galli A, France CP, Daws LC. 2005. Deficits in dopamine clearance and locomotion in hypoinsulinemic rats unmask novel modulation of dopamine transporters by amphetamine. J Neurochem 94:1402-1410.
38. Patterson TA, Brot MD, Zavosh A, Schenk JO, Szot P, Figlewicz DP. 1998. Food deprivation decreases mRNA and activity of the rat dopamine transporter. Neuroendocrinology 68:11-20.
39. Paxinos G, Watson C. 1986. The rat brain in sterotaxic coordinates. New York: Academic Press.
40. Phillips PE, Walton ME, Jhou TC. 2007. Calculating utility: Preclinical evidence for cost-benefit analysis by mesolimbic dopamine. Psychopharmacology 191:483-495.
41. Pijl H. 2003. Reduced dopaminergic tone in hypothalamic neural circuits: Expression of a "thrifty" genotype underlying the metabolic syndrome? Eur J Pharmacol 480(1-3): 125-131.
42. Pothos EN, Creese I, Hoebel BG. 1995a. Restricted eating with weight loss selectively decreases extracellular dopamine in the nucleus accumbens and alters dopamine response to amphetamine, morphine, and food intake. J Neurosci 15:6640-6650.
43. Pothos EN, Hernandez L, Hoebel BG. 1995b. Chronic food deprivation decreases extracellular dopamine in the nucleus accumbens: Implications for a possible neurochemical link between weight loss and drug abuse. Obes Res 3 (Suppl 4):525S-529S.
44. Pothos EN, Davila V, Sulzer D. 1998. Presynaptic recording of quanta from midbrain dopamine neurons and modulation of the quantal size. J Neurosci 18:4106-4118.
45. Schultz W, Tremblay L, Hollerman JR. 2000. Reward processing in primate orbitofrontal cortex and basal ganglia. Cereb Cortex 10:272-284.
46. Seeman P, Kapur S. 2003. Anesthetics inhibit high-affinity states of dopamine D2 and other G-linked receptors. Synapse NY 50:35-40.
47. Shimizu H, Shimomura Y, Takahashi M, Uehara Y, Fukatsu A, Sato N. 1991. Altered ambulatory activity and related brain monoamine metabolism in genetically obese Zucker rats. Exp Clin Endocrinol 97:39-44.
48. Small DM, Jones-Gotman M, Dagher A. 2003. Feeding-induced dopamine release in dorsal striatum correlates with meal pleasantness ratings in healthy human volunteers. Neuroimage 19:1709-1715.
49. Stern J, Johnson PR, Greenwood MR, Zucker LM, Hirsch J. 1972. Insulin resistance and pancreatic insulin release in the genetically obese Zucker rat. Proc Soc Exp Biol Med 139:66-69.
50. Thanos PK, Taintor NB, Alexoff D, Vaska P, Logan J, Grandy DK, Fang Y, Lee JH, Fowler JS, Volkow ND. 2002. In vivo comparative imaging of dopamine D2 knockout and wild-type mice with (11)C-raclopride and microPET. J Nucl Med 43:1570-1577.
51. Vivo M, Lin H, Strange PG. 2006. Investigation of cooperativity in the binding of ligands to the D(2) dopamine receptor. Mol Pharmacol 69:226-235.
52. Volkow ND, Wang GJ, Fowler JS, Logan J, Gatley SJ, Gifford A, Hitzemann R, Ding YS, Pappas N. 1999. Prediction of reinforcing responses to psychostimulants in humans by brain dopamine D2 receptor levels. Am J Psychiatry 156:1440-1443.
53. Volkow ND, Wang GJ, Fowler JS, Logan J, Jayne M, Franceschi D, Wong C, Gatley SJ, Gifford AN, Ding YS, Pappas N. 2002. ";Nonhedonic" food motivation in humans involves dopamine in the dorsal striatum and methylphenidate amplifies this effect. Synapse 44:175-180.
54. Wang GJ, Volkow ND, Logan J, Pappas NR, Wong CT, Zhu W, Netusil N, Fowler JS. 2001. Brain dopamine and obesity. Lancet 357:354-357.
55. Wang GJ, Volkow ND, Thanos PK, Fowler JS. 2003. Positron emission tomographic evidence of similarity between obesity and drug addiction. Psychiatr Ann 33:104-111.
56. Wang GJ, Volkow ND, Thanos PK, Fowler JS. 2004. Similarity between obesity and drug addiction as assessed by neurofunctional imaging: A concept review. J Addict Dis 23:39-53.
57. Woods RP, Cherry SR, Mazziotta JC. 1992. Rapid automated algorithm for aligning and reslicing PET images. J Comput Assist Tomogr 16:620-633.
58. Woods RP, Mazziotta JC, Cherry SR. 1993. MRI-PET registration with automated algorithm. J Comput Assist Tomogr 17:536-546.
59. Zucker LM, Antoniades HN. 1972. Insulin and obesity in the Zucker genetically obese rat "fatty". Endocrinology 90:1320-1330.