Chromothripsis: A New Mechanism for Rapid Karyotype Evolution

Annual Review of Genetics

Volumn 49, Issue , 2015, Pages 183-211

  Leibowitz, Mitchell L ^a,b   Zhang, Cheng Zhong ^a,b,c   Pellman, David ^a,b,c,d  

^a DANA FARBER CANCER INSTITUTE   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^d HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

Chromosome bridge; Complex chromosomal rearrangement; Genome evolution; Micronuclei; Nuclear envelope rupture; Single cell sequencing

Indexed keywords

DNA;

ARTICLE; CHROMOSOME; CHROMOSOME ABERRATION; CHROMOSOME DAMAGE; CHROMOSOME REARRANGEMENT; CHROMOSOME TRANSLOCATION; CHROMOSOMES AND CHROMOSOMAL PHENOMENA; CHROMOTHRIPSIS; DAUGHTER CELL; DNA DAMAGE; DNA REPLICATION; DOUBLE MINUTE CHROMOSOME; GENE AMPLIFICATION; GENOMICS; HUMAN; KARYOTYPE EVOLUTION; MICRONUCLEUS; MUTAGENESIS; NEOCHROMOSOME; NONHUMAN; PRIORITY JOURNAL; RING CHROMOSOME; SISTER CHROMATID EXCHANGE; CELL NUCLEUS MEMBRANE; EVOLUTION; GENE REARRANGEMENT; GENETICS; HUMAN CHROMOSOME; KARYOTYPE; PHYSIOLOGY;

BIOLOGICAL EVOLUTION; CHROMOSOMES; CHROMOSOMES, HUMAN; GENE REARRANGEMENT; HUMANS; KARYOTYPE; MICRONUCLEI, CHROMOSOME-DEFECTIVE; MUTAGENESIS; NUCLEAR ENVELOPE; RING CHROMOSOMES;

EID: 84948774105     PISSN: 00664197     EISSN: 15452948     Source Type: Book Series    
DOI: 10.1146/annurev-genet-120213-092228     Document Type: Article

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